recent publications
-
academic article
- Zhang, Y. A., Yaw, N., Snyder, S. A. General synthetic approach for the Laurencia family of natural products empowered by a potentially biomimetic ring expansion Journal of the American Chemical Society 2019 141:7776-7788 DOI:10.1021/jacs.9b01088 PMID:30998347
- Hu, P., Chi, H. M., DeBacker, K. C., Gong, X., Keim, J. H., Hsu, I. T., Snyder, S. A. Quaternary-centre-guided synthesis of complex polycyclic terpenes Nature 2019 569:703-707 DOI:10.1038/s41586-019-1179-2 PMID:31022719
- Ozog, S., Timberlake, N. D., Hermann, K., Garijo, O., Haworth, K. G., Shi, G., Glinkerman, C. M., Schefter, L. E., D'Souza, S., Simpson, E., Sghia-Hughes, G., Carillo, R. R., et al. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes Blood 2019 134:1298-1311 DOI:10.1182/blood.2019000040 PMID:31416800
- Yang, M., Yin, F., Fujino, H., Snyder, S. A. The total synthesis of chalcitrin Journal of the American Chemical Society 2019 141:4515-4520 DOI:10.1021/jacs.8b12612 PMID:30813728
- Zhou, Z., Gao, A. X., Snyder, S. A. Total synthesis of (+)-arborisidine Journal of the American Chemical Society 2019 141:7715-7720 DOI:10.1021/jacs.9b03248 PMID:31017434
- Lisnyak, V. G., Lynch-Colameta, T., Snyder, S. A. Mannich-type reactions of cyclic nitrones: effective methods for the enantioselective synthesis of piperidine-containing alkaloids Angewandte Chemie-International Edition 2018 57:15162-15166 DOI:10.1002/anie.201809799 PMID:30276949
- Cole, C. J. F., Chi, H. M., DeBacker, K. C., Snyder, S. A. Synthesis of enhanced, isolable disulfanium salts and their application to thiiranium-promoted polyene cyclizations Synthesis-Stuttgart 2018 50:4351-4358 DOI:10.1055/s-0037-1609754
- Gan, P., Pitzen, J., Qu, P., Snyder, S. A. Total synthesis of the caged indole alkaloid arboridinine enabled by aza-Prins and metal-mediated cyclizations Journal of the American Chemical Society 2018 140:919-925 DOI:10.1021/jacs.7b07724 PMID:29309137
- Smith, M. W., Zhou, Z., Gao, A. X., Shimbayashi, T., Snyder, S. A. A 7-step formal asymmetric total synthesis of strictamine via an asymmetric propargylation and metal-mediated cyclization Organic Letters 2017 19:1004-1007 DOI:10.1021/acs.orglett.6b03839 PMID:28253628
- Snyder, S. A., Porco, J. A. Advancing science through synthetic chemistry and chemical biology: special issue in honor of the 2016 Wolf prize laureates in chemistry, Professors Kyriacos C. Nicolaou and Stuart L. Schreiber Israel Journal of Chemistry 2017 57:173-173 DOI:10.1002/ijch.201700010
- Schevenels, F. T., Shen, M., Snyder, S. A. Alkyldisulfanium salts: isolable, electrophilic sulfur reagents competent for polyene cyclizations Organic Letters 2017 19:2-5 DOI:10.1021/acs.orglett.6b02059 PMID:27973855
- Hu, P., Snyder, S. A. Enantiospecific total synthesis of the highly strained (-)-presilphiperfolan-8-ol via a Pd-catalyzed tandem cyclization Journal of the American Chemical Society 2017 139:5007-5010 DOI:10.1021/jacs.7b01454 PMID:28355073
- Schevenels, F. T., Shen, M., Snyder, S. A. Isolable and readily handled halophosphonium pre-reagents for hydro- and deuteriohalogenation Journal of the American Chemical Society 2017 139:6329-6337 DOI:10.1021/jacs.6b12653 PMID:28462991
- Snyder, S. A. Strategies and tactics for the synthesis of complex alkaloids Chimia 2017 71:802-809 DOI:10.2533/chimia.2017.802 PMID:29289241
- Ye, Q., Qu, P., Snyder, S. A. Total syntheses of scaparvins B, C, and D enabled by a Key C-H functionalization Journal of the American Chemical Society 2017 139:18428-18431 DOI:10.1021/jacs.7b06185 PMID:29227651
- Gan, P., Smith, M. W., Braffman, N. R., Snyder, S. A. Pyrone Diels-Alder routes to indolines and hydroindolines: syntheses of gracilamine, mesembrine, and Δ(7) -mesembrenone Angewandte Chemie-International Edition 2016 55:3625-3630 DOI:10.1002/anie.201510520 PMID:26865400
- Shen, M., Kretschmer, M., Brill, Z. G., Snyder, S. A. Strategies for the total synthesis of diverse bromo-chamigrenes Organic Letters 2016 18:5018-5021 DOI:10.1021/acs.orglett.6b02478 PMID:27660885
- Gao, A. X., Hamada, T., Snyder, S. A. The enantioselective total synthesis of exochomine Angewandte Chemie-International Edition 2016 55:10301-10306 DOI:10.1002/anie.201604744 PMID:27443416
- Quideau, S., Snyder, S. A. Chemistry in the vine and wine sciences Preface Tetrahedron 2015 71:2969-2970 DOI:10.1016/j.tet.2015.02.086
- Levinson, A. M., Milner, P. J., Snyder, S. A. Studies in selective 6-membered bromoether formation via bromonium and thiiranium-induced cyclizations Tetrahedron Letters 2015 56:3553-3556 DOI:10.1016/j.tetlet.2015.02.065
- Eagan, J. M., Hori, M., Wu, J., Kanyiva, K. S., Snyder, S. A. Synthesis and applications of Hajos-Parrish ketone isomers Angewandte Chemie-International Edition 2015 54:7842-7846 DOI:10.1002/anie.201500925 PMID:25974879 PMCID:PMC4737474
- Wright, N. E., ElSohly, A. M., Snyder, S. A. Syntheses of cyclotriveratrylene analogues and their long elusive triketone congeners Organic Letters 2014 16:3644-3647 DOI:10.1021/ol501284s PMID:24987807 PMCID:PMC4334237
- Wright, N. E., Snyder, S. A. 9-membered carbocycle formation: development of distinct Friedel-Crafts cyclizations and application to a scalable total synthesis of ( +/-)- caraphenol A Angewandte Chemie-International Edition 2014 53:3409-3413 DOI:10.1002/anie.201311299 PMID:24677499 PMCID:PMC4106019
- Sherwood, T. C., Trotta, A. H., Snyder, S. A. A strategy for complex dimer formation when biomimicry fails: total synthesis of ten coccinellid alkaloids Journal of the American Chemical Society 2014 136:9743-9753 DOI:10.1021/ja5045852 PMID:24959981 PMCID:PMC4105056
- Snyder, S. A., Berova, N. Asymmetric alkene halogenation Chirality 2014 26:327-327 DOI:10.1002/chir.22345 PMID:24946765
- Griffith, D. R., Botta, L., St Denis, T. G., Snyder, S. A. Explorations of caffeic acid derivatives: total syntheses of rufescenolide, yunnaneic acids C and D, and studies toward yunnaneic acids A and B Journal of Organic Chemistry 2014 79:88-105 DOI:10.1021/jo4023167 PMID:24328186
- Jepsen, T. H., Thomas, S. B., Lin, Y., Stathakis, C. I., de Miguel, I., Snyder, S. A. Harnessing quinone methides: total synthesis of (+/-)-vaticanol A Angewandte Chemie-International Edition 2014 53:6747-6751 DOI:10.1002/anie.201402858 PMID:24841889 PMCID:PMC4106016
- ElSohly, A. M., Wespe, D. A., Poore, T. J., Snyder, S. A. An efficient approach to the securinega alkaloids empowered by cooperative N-heterocyclic carbene/Lewis acid catalysis Angewandte Chemie - International Edition 2013 52:5789-5794 DOI:10.1002/anie.201301849 PMID:23610056
- Treitler, D. S., Li, Z. F., Krystal, M., Meanwell, N. A., Snyder, S. A. Evaluation of HIV-1 inhibition by stereoisomers and analogues of the sesquiterpenoid hydroquinone peyssonol A Bioorganic & Medicinal Chemistry Letters 2013 23:2192-2196 DOI:10.1016/j.bmcl.2013.01.098 PMID:23434230
- Brucks, A. P., Treitler, D. S., Liu, S. A., Snyder, S. A. Explorations into the potential of chiral sulfonium reagents to effect asymmetric halonium additions to isolated alkenes Synthesis-Stuttgart 2013 45:1886-1898 DOI:10.1055/s-0033-1338865
- Snyder, S. A., Brucks, A. P., Treitler, D. S., Moga, I. Concise synthetic approaches for the Laurencia family: formal total syntheses of (±)-laurefucin and (±)-E- and (±)-Z-pinnatifidenyne Journal of the American Chemical Society 2012 134:17714-17721 DOI:10.1021/ja3076988 PMID:23057834
- Snyder, S. A., Kontes, F., ElSohly, A. M. Mechanistic investigations of the cyclocondensation step of the Knorr pyrrole synthesis Heterocycles 2012 84:265-274 DOI:10.3987/com-11-s(p)5
- Snyder, S. A., Thomas, S. B., Mayer, A. C., Breazzano, S. P. Total syntheses of hopeanol and hopeahainol A empowered by a chiral Brønsted acid induced pinacol rearrangement Angewandte Chemie-International Edition 2012 51:4080-4084 DOI:10.1002/anie.201107730 PMID:22431237 PMCID:PMC3744884
- Snyder, S. A., Wespe, D. A., von Hof, J. M. A concise, stereocontrolled total synthesis of rippertenol Journal of the American Chemical Society 2011 133:8850-8853 DOI:10.1021/ja202859f PMID:21574654
- Snyder, S. A., Treitler, D. S., Brucks, A. P., Sattler, W. A general strategy for the stereocontrolled preparation of diverse 8- and 9-membered Laurencia-type bromoethers Journal of the American Chemical Society 2011 133:15898-15901 DOI:10.1021/ja2069449 PMID:21919540
- Snyder, S. A. Natural product synthesis: Making nematodes nervous Nature Chemistry 2011 3:422-423 DOI:10.1038/nchem.1059 PMID:21602850
- Snyder, S. A., Gollner, A., Chiriac, M. I. Regioselective reactions for programmable resveratrol oligomer synthesis Nature 2011 474:461-466 DOI:10.1038/nature10197 PMID:21697944 PMCID:PMC3179663
- Snyder, S. A., Brill, Z. G. Structural revision and total synthesis of caraphenol B and C Organic Letters 2011 13:5524-5527 DOI:10.1021/ol2022406 PMID:21942557 PMCID:PMC3224822
- Snyder, S. A., Treitler, D. S., Satoh, N., Fukuyama, T. Synthesis of Et2SBr•SbCI5Br and its use in biomimetic brominative polyene cyclizations Organic Syntheses 2011 88:54-69 DOI:10.1002/0471264229.os088.06
- Snyder, S. A., ElSohly, A. M., Kontes, F. Synthetic approaches to oligomeric natural products Natural Product Reports 2011 28:897-924 DOI:10.1039/c1np00001b PMID:21412558
- Snyder, S. A., Kontes, F. Synthetic studies of biomimetic Diels-Alder processes toward the helicterin family of natural products Israel Journal of Chemistry 2011 51:378-390 DOI:10.1002/ijch.201100004
- Snyder, S. A., Wright, N. E., Pflueger, J. J., Breazzano, S. P. Total syntheses of heimiol A, hopeahainol D, and constrained analogues Angewandte Chemie-International Edition 2011 50:8629-8633 DOI:10.1002/anie.201103575 PMID:21793142 PMCID:PMC3263399
- Snyder, S. A., Treitler, D. S., Schall, A. A two-step mimic for direct, asymmetric bromonium- and chloronium-induced polyene cyclizations Tetrahedron 2010 66:4796-4804 DOI:10.1016/j.tet.2010.03.037
- Snyder, S. A. Organic chemistry: Symmetrizing the unsymmetrical Nature 2010 465:560-561 DOI:10.1038/465560a PMID:20520702
- Welsch, M. E., Snyder, S. A., Stockwell, B. R. Privileged scaffolds for library design and drug discovery Current Opinion in Chemical Biology 2010 14:347-361 DOI:10.1016/j.cbpa.2010.02.018 PMID:20303320 PMCID:PMC2908274
- Snyder, S. A., Treitler, D. S., Brucks, A. P. Simple reagents for direct halonium-induced polyene cyclizations Journal of the American Chemical Society 2010 132:14303-14314 DOI:10.1021/ja106813s PMID:20858010
- Snyder, S. A., ElSohly, A. M., Kontes, F. Synthetic and theoretical investigations of myrmicarin biosynthesis Angewandte Chemie-International Edition 2010 49:9693-9698 DOI:10.1002/anie.201005825 PMID:21069649
- Snyder, S. A., Sherwood, T. C., Ross, A. G. Total syntheses of dalesconol A and B Angewandte Chemie-International Edition 2010 49:5146-5150 DOI:10.1002/anie.201002264 PMID:20572237 PMCID:PMC3075011
- Snyder, S. A., Tang, Z. Y., Gupta, R. Enantioselective total synthesis of (-)-napyradiomycin A1 via asymmetric chlorination of an isolated olefin Journal of the American Chemical Society 2009 131:5744-5745 DOI:10.1021/ja9014716 PMID:19338329
- Snyder, S. A., Treitler, D. S. Et2SBrSbCl5Br: an effective reagent for direct bromonium-induced polyene cyclizations Angewandte Chemie-International Edition 2009 48:7899-7903 DOI:10.1002/anie.200903834 PMID:19757473
- Snyder, S. A., Kontes, F. Explorations into neolignan biosynthesis: concise total syntheses of helicterin B, helisorin, and helisterculin A from a common intermediate Journal of the American Chemical Society 2009 131:1745-1752 DOI:10.1021/ja806865u PMID:19191699
- Pors, K., Goldberg, F. W., Leamon, C. P., Rigby, A. C., Snyder, S. A., Falconer, R. A. The changing landscape of cancer drug discovery: a challenge to the medicinal chemist of tomorrow Drug Discovery Today 2009 14:1045-1050 DOI:10.1016/j.drudis.2009.07.004 PMID:19638319
- Snyder, S. A.*, Breazzano, S. P.*, Ross, A. G., Lin, Y., Zografos, A. L. Total synthesis of diverse carbogenic complexity within the resveratrol class from a common building block Journal of the American Chemical Society 2009 131:1753-1765 DOI:10.1021/ja806183r PMID:19143488 (* = equal contribution)
- Snyder, S. A., Zografos, A. L., Lin, Y. Total synthesis of resveratrol-based natural products: A chemoselective solution Angewandte Chemie-International Edition 2007 46:8186-8191 DOI:10.1002/anie.200703333 PMID:17890663
- Snyder, S. A., Corey, E. J. Concise total syntheses of palominol, dolabellatrienone, beta-araneosene, and isoedunol via an enantioselective Diels-Alder macrobicyclization Journal of the American Chemical Society 2006 128:740-742 DOI:10.1021/ja0576379 PMID:16417362
- Snyder, S. A. From abyssomicin to zaragozic acid: Chemical synthesis and drug innovation Angewandte Chemie-International Edition 2006 45:4714-4714 DOI:10.1002/anie.200602427
- Snyder, S. A., Corey, E. J. Regioselective aldol condensations of a cholestanone-derived dialdehyde: new twists on a classic reaction Tetrahedron Letters 2006 47:2083-2086 DOI:10.1016/j.tetlet.2006.01.136
-
Nicolaou, K. C.*, Snyder, S. A.*
Chasing molecules that were never there: Misassigned natural products and the role of chemical synthesis in modern structure elucidation
Angewandte Chemie-International Edition
2005
44:1012-1044
DOI:10.1002/anie.200460864
PMID:15688428
(* = equal contribution)
-
Nicolaou, K. C.*, Snyder, S. A.*, Nalbandian, A. Z., Longbottom, D. A.
A new method for the stereoselective synthesis of α- and β-glycosylamines using the burgess reagent
Journal of the American Chemical Society
2004
126:6234-6235
DOI:10.1021/ja049293c
PMID:15149212
(* = equal contribution)
-
Nicolaou, K. C., Chen, D. Y. K., Huang, X. H., Ling, T. T., Bella, M., Snyder, S. A.
Chemistry and biology of diazonamide A: First total synthesis and confirmation of the true structure
Journal of the American Chemical Society
2004
126:12888-12896
DOI:10.1021/ja040092i
PMID:15469286
-
Nicolaou, K. C., Hao, J. L., Reddy, M. V., Rao, P. B., Rassias, G., Snyder, S. A., Huang, X. H., Chen, D. Y. K., Brenzovich, W. E., Giuseppone, N., Giannakakou, P., O'Brate, A.
Chemistry and biology of diazonamide A: Second total synthesis and biological investigations
Journal of the American Chemical Society
2004
126:12897-12906
DOI:10.1021/ja040093a
PMID:15469287
-
Nicolaou, K. C.*, Snyder, S. A.*, Longbottom, D. A., Nalbandian, A. Z., Huang, X. H.
New uses for the burgess reagent in chemical synthesis: Methods for the facile and stereoselective formation of sulfamidates, glycosylamines, and sulfamides
Chemistry-a European Journal
2004
10:5581-5606
DOI:10.1002/chem.200400503
PMID:15470695
(* = equal contribution)
-
Nicolaou, K. C.*, Snyder, S. A.*, Giuseppone, N., Huang, X. H., Bella, M., Reddy, M. V., Rao, P. B., Koumbis, A. E., Giannakakou, P., O'Brate, A.
Studies toward diazonamide A: Development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure
Journal of the American Chemical Society
2004
126:10174-10182
DOI:10.1021/ja040091q
PMID:15303893
(* = equal contribution)
-
Nicolaou, K. C.*, Snyder, S. A.*, Huang, X. H., Simonsen, K. B., Koumbis, A. E., Bigot, A.
Studies toward diazonamide A: Initial synthetic forays directed toward the originally proposed structure
Journal of the American Chemical Society
2004
126:10162-10173
DOI:10.1021/ja040090y
PMID:15303892
(* = equal contribution)
-
Nicolaou, K. C.*, Snyder, S. A.*
The essence of total synthesis
Proceedings of the National Academy of Sciences of the United States of America
2004
101:11929-11936
DOI:10.1073/pnas.0403799101
PMID:15302925
PMCID:PMC514411
(* = equal contribution)
-
Nicolaou, K. C.*, Snyder, S. A.*
Cascade reactions in total synthesis. Recent advances
Actualite Chimique
2003
83-88
(* = equal contribution)
-
Nicolaou, K. C., Montagnon, T., Snyder, S. A.
Tandem reactions, cascade sequences, and biomimetic strategies in total synthesis
Chemical Communications
2003
551-564
DOI:10.1039/b209440c
-
Nicolaou, K. C., Rao, P. B., Hao, J. L., Reddy, M. V., Rassias, G., Huang, X. H., Chen, D. Y. K., Snyder, S. A.
The second total synthesis of diazonamide A
Angewandte Chemie-International Edition
2003
42:1753-1758
DOI:10.1002/anie.200351112
PMID:12707898
-
Nicolaou, K. C., Longbottom, D. A., Snyder, S. A., Nalbanadian, A. Z., Huang, X. H.
A new method for the synthesis of nonsymmetrical sulfamides using burgess-type reagents
Angewandte Chemie-International Edition
2002
41:3866-3870
DOI:10.1002/1521-3773(20021018)41:20<3866::aid-anie3866>3.0.co;2-t
PMID:12386873
-
Nicolaou, K. C., Huang, X. H., Snyder, S. A., Rao, P. B., Bella, M., Reddy, M. V.
A novel regio- and stereoselective synthesis of sulfamidates from 1,2-diols using burgess and related reagents: A facile entry into β-amino alcohols
Angewandte Chemie-International Edition
2002
41:834-838
DOI:10.1002/1521-3773(20020301)41:5<834::aid-anie834>3.0.co;2-v
PMID:12491352
-
Nicolaou, K. C.*, Snyder, S. A.*, Montagnon, T., Vassilikogiannakis, G.
The Diels-Alder reaction in total synthesis
Angewandte Chemie-International Edition
2002
41:1668-1698
DOI:10.1002/1521-3773(20020517)41:10<1668::aid-anie1668>3.0.co;2-z
PMID:19750686
(* = equal contribution)
-
Nicolaou, K. C., Bella, M., Chen, D. Y. K., Huang, X. H., Ling, T. T., Snyder, S. A.
Total synthesis of diazonamide A
Angewandte Chemie-International Edition
2002
41:3495-3499
DOI:10.1002/1521-3773(20020916)41:18<3495::aid-anie3495>3.0.co;2-7
PMID:12298077
-
Nicolaou, K. C., Huang, X., Giuseppone, N., Rao, P. B., Bella, M., Reddy, M. V., Snyder, S. A.
Construction of the complete aromatic core of diazonamide a by a novel hetero pinacol macrocyclization cascade reaction
Angewandte Chemie-International Edition
2001
40:4705-4709
DOI:10.1002/1521-3773(20011217)40:24<4705::aid-anie4705>3.0.co;2-d
PMID:12404390
- Snyder, S. A., Vosburg, D. A., Jarvis, M. G., Markgraf, J. H. Intramolecular hetero Diels-Alder routes to γ-carboline alkaloids Tetrahedron 2000 56:5329-5335 DOI:10.1016/s0040-4020(00)00468-3
-
Nicolaou, K. C.*, Snyder, S. A.*, Simonsen, K. B., Koumbis, A. E.
Model studies towards diazonamide A: Synthesis of the heterocyclic core
Angewandte Chemie-International Edition
2000
39:3473-3478
DOI:10.1002/1521-3773(20001002)39:19<3473::aid-anie3473>3.0.co;2-e
PMID:11091394
(* = equal contribution)
-
Nicolaou, K. C., Koumbis, A. E., Snyder, S. A., Simonsen, K. B.
Novel reactions initiated by titanocene methylidenes: Deoxygenation of sulfoxides, n-oxides, and selenoxides
Angewandte Chemie-International Edition
2000
39:2529-2533
DOI:10.1002/1521-3773(20000717)39:14<2529::aid-anie2529>3.0.co;2-e
PMID:10941126
-
Nicolaou, K. C.*, Snyder, S. A.*, Bigot, A., Pfefferkorn, J. A.
Solution and solid-phase synthesis of functionalized 3-arylbenzofurans by a novel cyclofragmentation-release pathway
Angewandte Chemie-International Edition
2000
39:1093-1096
DOI:10.1002/(sici)1521-3773(20000317)39:6<1093::aid-anie1093>3.3.co;2-j
PMID:10760931
(* = equal contribution)
- Markgraf, J. H., Sangani, P. K., Manalansan, R. J., Snyder, S. A., Thummel, R. P. Strained heterocyclic systems. Part 21. The Menschutkin reaction Journal of Chemical Research-S 2000 2000:561-563 DOI:10.3184/030823400103166184
- Markgraf, J. H., Snyder, S. A., Vosburg, D. A. A concise route to isocanthin-6-one Tetrahedron Letters 1998 39:1111-1112 DOI:10.1016/s0040-4039(97)10794-8
- Cao, F. L., Eckert, R., Elfgang, C., Nitsche, J. M., Snyder, S. A., Hulser, D. F., Willecke, K., Nicholson, B. J. A quantitative analysis of connexin-specific permeability differences of gap junctions expressed in HeLa transfectants and Xenopus oocytes Journal of Cell Science 1998 111:31-43 PMID:9394010
-
book
- Solomons, T. W. Graham, Fryhle, Craig B., Snyder, S. A. Organic chemistry 2016
-
Nicolaou, K. C.*, Snyder, Scott A.*
Classics in total synthesis II : more targets, strategies, methods
Weinheim: Wiley-VCH.
2003
(* = equal contribution)
-
chapter
- Gao, A. X., Thomas, S. B., Snyder, S. A. Pinacol and semipinacol rearrangements in total synthesis Molecular Rearrangements in Organic Synthesis. 1-34. 2015 DOI:10.1002/9781118939901.ch1
