recent publications
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academic article
- Brown, B. P., Zhang, Y. K., Westover, D., Yan, Y., Qiao, H., Huang, V., Du, Z., Smith, J. A., Ross, J. S., Miller, V. A., Ali, S., Bazhenova, L., et al. On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation Clinical Cancer Research 2019 25:3341-3351 DOI:10.1158/1078-0432.ccr-18-3829 PMID:30796031 PMCID:PMC6548651
- Huang, H., Kuenze, G., Smith, J. A., Taylor, K. C., Duran, A. M., Hadziselimovic, A., Meiler, J., Vanoye, C. G., George, A. L., Sanders, C. R. Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations Science Advances 2018 4 DOI:10.1126/sciadv.aar2631 PMID:29532034 PMCID:PMC5842040
- Schulte, M. L., Fu, A., Zhao, P., Li, J., Geng, L., Smith, S. T., Kondo, J., Coffey, R. J., Johnson, M. O., Rathmell, J. C., Sharick, J. T., Skala, M. C., et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models Nature Medicine 2018 24:194-202 DOI:10.1038/nm.4464 PMID:29334372 PMCID:PMC5803339
- Gilmore, P., Sundaresan, V. B., Seidt, J., Smith, J. Design and analysis of a synthetic jet actuator-based fluid atomization device Journal of Intelligent Material Systems and Structures 2017 28:2307-2316 DOI:10.1177/1045389x17689938
- Li, J., Smith, J. A., Dawson, E. S., Fu, A., Nickels, M. L., Schulte, M. L., Manning, H. C. Optimized translocator protein ligand for optical molecular imaging and screening Bioconjugate Chemistry 2017 28:1016-1023 DOI:10.1021/acs.bioconjchem.6b00711 PMID:28156095
- Deatherage, C. L., Lu, Z., Kroncke, B. M., Ma, S., Smith, J. A., Voehler, M. W., McFeeters, R. L., Sanders, C. R. Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains Science Advances 2017 3 DOI:10.1126/sciadv.1602794 PMID:28439555 PMCID:PMC5389784
- Kroncke, B. M., Van Horn, W. D., Smith, J., Kang, C., Welch, R. C., Song, Y., Nannemann, D. P., Taylor, K. C., Sisco, N. J., George Jr., A. L., Meiler, J., Vanoye, C. G., et al. Structural basis for KCNE3 modulation of potassium recycling in epithelia Science Advances 2016 2 DOI:10.1126/sciadv.1501228 PMID:27626070 PMCID:PMC5017827
- Schulte, M. L., Khodadadi, A. B., Cuthbertson, M. L., Smith, J. A., Manning, H. C. 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport Bioorganic & Medicinal Chemistry Letters 2016 26:1044-1047 DOI:10.1016/j.bmcl.2015.12.031 PMID:26750251 PMCID:PMC4727990
- McCulloch, K. M., McCranie, E. K., Smith, J. A., Sarwar, M., Mathieu, J. L., Gitschlag, B. L., Du, Y., Bachmann, B. O., Iverson, T. M. Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily Proceedings of the National Academy of Sciences of the United States of America 2015 112:11547-11552 DOI:10.1073/pnas.1500964112 PMID:26240321 PMCID:PMC4577193
- Edwards, S. J., Moth, C. W., Kim, S., Brandon, S., Zhou, Z., Cobb, C. E., Hustedt, E. J., Beth, A. H., Smith, J. A., Lybrand, T. P. Automated structure refinement for a protein heterodimer complex using limited EPR spectroscopic data and a rigid-body docking algorithm: a three-dimensional model for an ankyrin-CDB3 complex Journal of Physical Chemistry B 2014 118:4717-4726 DOI:10.1021/jp4099705 PMID:24758720 PMCID:PMC4018176
- Smith, J. A., Edwards, S. J., Moth, C. W., Lybrand, T. P. TagDock: an efficient rigid body docking algorithm for oligomeric protein complex model construction and experiment planning Biochemistry 2013 52:5577-5584 DOI:10.1021/bi400158k PMID:23875708 PMCID:PMC3804560
- Egli, M., Pattanayek, R., Sheehan, J. H., Xu, Y., Mori, T., Smith, J. A., Johnson, C. H. Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock Biochemistry 2013 52:1208-1220 DOI:10.1021/bi301691a PMID:23351065 PMCID:PMC3587310
- Yang, T., Smith, J. A., Leake, B. F., Sanders, C. R., Meiler, J., Roden, D. M. An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1 Molecular Pharmacology 2013 83:481-489 DOI:10.1124/mol.112.081513 PMID:23193163 PMCID:PMC3558809
- Kim, S., Brandon, S., Zhou, Z., Cobb, C. E., Edwards, S. J., Moth, C. W., Parry, C. S., Smith, J. A., Lybrand, T. P., Hustedt, E. J., Beth, A. H. Determination of structural models of the complex between the cytoplasmic domain of erythrocyte band 3 and ankyrin-R repeats 13-24 Journal of Biological Chemistry 2011 286:20746-20757 DOI:10.1074/jbc.M111.230326 PMID:21493712 PMCID:PMC3121456
- Pretto, D. I., Tsutakawa, S., Brosey, C. A., Castillo, A., Chagot, M. E., Smith, J. A., Tainer, J. A., Chazin, W. J. Structural dynamics and single-stranded DNA binding activity of the three n-terminal domains of the large subunit of replication protein a from small angle x-ray scattering Biochemistry 2010 49:2880-2889 DOI:10.1021/bi9019934 PMID:20184389 PMCID:PMC2847624
- Stepanovic, S. Z., Potet, F., Petersen, C. I., Smith, J. A., Meiler, J., Balser, J. R., Kupershmidt, S. The evolutionarily conserved residue A653 plays a key role in HERG channel closing Journal of Physiology-London 2009 587:2555-2566 DOI:10.1113/jphysiol.2008.166694 PMID:19406877 PMCID:PMC2714020
- Dong, E., Smith, J., Heinze, S., Alexander, N., Meiler, J. BCL::Align: sequence alignment and fold recognition with a custom scoring function online Gene 2008 422:41-46 DOI:10.1016/j.gene.2008.06.006 PMID:18601985 PMCID:PMC2658673
- Kang, C., Tian, C., Sonnichsen, F. D., Smith, J. A., Meiler, J., George Jr., A. L., Vanoye, C. G., Kim, H. J., Sanders, C. R. Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel Biochemistry 2008 47:7999-8006 DOI:10.1021/bi800875q PMID:18611041 PMCID:PMC2580054
- Smith, J. A., Vanoye, C. G., George Jr., A. L., Meiler, J., Sanders, C. R. Structural models for the KCNQ1 voltage-gated potassium channel Biochemistry 2007 46:14141-14152 DOI:10.1021/bi701597s PMID:17999538 PMCID:PMC2565492
- Sherman, D. H., Li, S., Yermalitskaya, L. V., Kim, Y., Smith, J. A., Waterman, M. R., Podust, L. M. The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae Journal of Biological Chemistry 2006 281:26289-26297 DOI:10.1074/jbc.M605478200 PMID:16825192 PMCID:PMC2939096
- Cho, Y. J., Wang, H., Kozekov, I. D., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Lloyd, R. S., Rizzo, C. J., Stone, M. P. Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence Chemical Research in Toxicology 2006 19:195-208 DOI:10.1021/tx050239z PMID:16485895 PMCID:PMC2631444
- Cho, Y. J., Wang, H., Kozekov, I. D., Kozekova, A., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Rizzo, C. J., Lloyd, R. S., Stone, M. P. Orientation of the crotonaldehyde-derived N2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5'-CpG-3' sequence Chemical Research in Toxicology 2006 19:1019-1029 DOI:10.1021/tx0600604 PMID:16918240
- Halasa, N. B., Whitlock, J. A., McCurley, T. L., Smith, J. A., Zhu, Q., Ochs, H., Dermody, T. S., Crowe Jr., J. E. Fatal hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection in a patient with a novel mutation in the signaling lymphocytic activation molecule-associated protein Clinical Infectious Diseases 2003 37:E136-E141 DOI:10.1086/379126 PMID:14583885
- Bassarello, C., Cimino, P., Bifulco, G., Boger, D. L., Smith, J. A., Chazin, W. J., Gomez-Paloma, L. NMR structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) covalent complex ChemBioChem 2003 4:1188-1193 DOI:10.1002/cbic.200300642 PMID:14613110
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Smith, J. A., Bifulco, G., Case, D. A., Boger, D. L., Gomez-Paloma, L., Chazin, W. J.
The structural basis for in situ activation of DNA alkylation by duocarmycin sa
Journal of Molecular Biology
2000
300:1195-1204
DOI:10.1006/jmbi.2000.3887
PMID:10903864
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Eis, P. S., Smith, J. A., Rydzewski, J. M., Case, D. A., Boger, D. L., Chazin, W. J.
High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA
Journal of Molecular Biology
1997
272:237-252
DOI:10.1006/jmbi.1997.1223
PMID:9299351
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Smith, J. A., Gomez-Paloma, L., Case, D. A., Chazin, W. J.
Molecular dynamics docking driven by NMR-derived restraints to determine the structure of the calicheamicin γ1(I) oligosaccharide domain complexed to duplex DNA
Magnetic Resonance in Chemistry
1996
34:S147-S155
DOI:10.1002/(SICI)1097-458X(199612)34:13
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Potts, B. C. M., Smith J., Akke, M., Macke, T. J., Okazaki, K., Hidaka, H., Case, D. A., Chazin, W. J.
The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins
Nature Structural Biology
1995
2:790-796
DOI:10.1038/nsb0995-790
PMID:7552751
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Paloma, L. G., Smith, J. A., Chazin, W. J., Nicolaou, K. C.
Interaction of calicheamicin with duplex DNA - role of the oligosaccharide domain and identification of multiple binding modes
Journal of the American Chemical Society
1994
116:3697-3708
DOI:10.1021/ja00088a005