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Smith, Jarrod Anson

Graduate Student
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Positions

  • 2006 - Research Scientist and Assistant Director, Vanderbilt Center for Structural Biology, Vanderbilt University

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  • Doctoral Dissertation
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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Brown, B. P., Zhang, Y. K., Westover, D., Yan, Y., Qiao, H., Huang, V., Du, Z., Smith, J. A., Ross, J. S., Miller, V. A., Ali, S., Bazhenova, L., et al. On-target Resistance to the Mutant-Selective EGFR Inhibitor Osimertinib Can Develop in an Allele-Specific Manner Dependent on the Original EGFR-Activating Mutation Clinical Cancer Research  2019 25:3341-3351  DOI:10.1158/1078-0432.ccr-18-3829  PMID:30796031  PMCID:PMC6548651
    • Huang, H., Kuenze, G., Smith, J. A., Taylor, K. C., Duran, A. M., Hadziselimovic, A., Meiler, J., Vanoye, C. G., George, A. L., Sanders, C. R. Mechanisms of KCNQ1 channel dysfunction in long QT syndrome involving voltage sensor domain mutations Science Advances  2018 4  DOI:10.1126/sciadv.aar2631  PMID:29532034  PMCID:PMC5842040
    • Schulte, M. L., Fu, A., Zhao, P., Li, J., Geng, L., Smith, S. T., Kondo, J., Coffey, R. J., Johnson, M. O., Rathmell, J. C., Sharick, J. T., Skala, M. C., et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models Nature Medicine  2018 24:194-202  DOI:10.1038/nm.4464  PMID:29334372  PMCID:PMC5803339
    • Gilmore, P., Sundaresan, V. B., Seidt, J., Smith, J. Design and analysis of a synthetic jet actuator-based fluid atomization device Journal of Intelligent Material Systems and Structures  2017 28:2307-2316  DOI:10.1177/1045389x17689938
    • Li, J., Smith, J. A., Dawson, E. S., Fu, A., Nickels, M. L., Schulte, M. L., Manning, H. C. Optimized translocator protein ligand for optical molecular imaging and screening Bioconjugate Chemistry  2017 28:1016-1023  DOI:10.1021/acs.bioconjchem.6b00711  PMID:28156095
    • Deatherage, C. L., Lu, Z., Kroncke, B. M., Ma, S., Smith, J. A., Voehler, M. W., McFeeters, R. L., Sanders, C. R. Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains Science Advances  2017 3  DOI:10.1126/sciadv.1602794  PMID:28439555  PMCID:PMC5389784
    • Kroncke, B. M., Van Horn, W. D., Smith, J., Kang, C., Welch, R. C., Song, Y., Nannemann, D. P., Taylor, K. C., Sisco, N. J., George Jr., A. L., Meiler, J., Vanoye, C. G., et al. Structural basis for KCNE3 modulation of potassium recycling in epithelia Science Advances  2016 2  DOI:10.1126/sciadv.1501228  PMID:27626070  PMCID:PMC5017827
    • Schulte, M. L., Khodadadi, A. B., Cuthbertson, M. L., Smith, J. A., Manning, H. C. 2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport Bioorganic & Medicinal Chemistry Letters  2016 26:1044-1047  DOI:10.1016/j.bmcl.2015.12.031  PMID:26750251  PMCID:PMC4727990
    • McCulloch, K. M., McCranie, E. K., Smith, J. A., Sarwar, M., Mathieu, J. L., Gitschlag, B. L., Du, Y., Bachmann, B. O., Iverson, T. M. Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily Proceedings of the National Academy of Sciences of the United States of America  2015 112:11547-11552  DOI:10.1073/pnas.1500964112  PMID:26240321  PMCID:PMC4577193
    • Edwards, S. J., Moth, C. W., Kim, S., Brandon, S., Zhou, Z., Cobb, C. E., Hustedt, E. J., Beth, A. H., Smith, J. A., Lybrand, T. P. Automated structure refinement for a protein heterodimer complex using limited EPR spectroscopic data and a rigid-body docking algorithm: a three-dimensional model for an ankyrin-CDB3 complex Journal of Physical Chemistry B  2014 118:4717-4726  DOI:10.1021/jp4099705  PMID:24758720  PMCID:PMC4018176
    • Smith, J. A., Edwards, S. J., Moth, C. W., Lybrand, T. P. TagDock: an efficient rigid body docking algorithm for oligomeric protein complex model construction and experiment planning Biochemistry  2013 52:5577-5584  DOI:10.1021/bi400158k  PMID:23875708  PMCID:PMC3804560
    • Egli, M., Pattanayek, R., Sheehan, J. H., Xu, Y., Mori, T., Smith, J. A., Johnson, C. H. Loop-loop interactions regulate KaiA-stimulated KaiC phosphorylation in the cyanobacterial KaiABC circadian clock Biochemistry  2013 52:1208-1220  DOI:10.1021/bi301691a  PMID:23351065  PMCID:PMC3587310
    • Yang, T., Smith, J. A., Leake, B. F., Sanders, C. R., Meiler, J., Roden, D. M. An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1 Molecular Pharmacology  2013 83:481-489  DOI:10.1124/mol.112.081513  PMID:23193163  PMCID:PMC3558809
    • Kim, S., Brandon, S., Zhou, Z., Cobb, C. E., Edwards, S. J., Moth, C. W., Parry, C. S., Smith, J. A., Lybrand, T. P., Hustedt, E. J., Beth, A. H. Determination of structural models of the complex between the cytoplasmic domain of erythrocyte band 3 and ankyrin-R repeats 13-24 Journal of Biological Chemistry  2011 286:20746-20757  DOI:10.1074/jbc.M111.230326  PMID:21493712  PMCID:PMC3121456
    • Pretto, D. I., Tsutakawa, S., Brosey, C. A., Castillo, A., Chagot, M. E., Smith, J. A., Tainer, J. A., Chazin, W. J. Structural dynamics and single-stranded DNA binding activity of the three n-terminal domains of the large subunit of replication protein a from small angle x-ray scattering Biochemistry  2010 49:2880-2889  DOI:10.1021/bi9019934  PMID:20184389  PMCID:PMC2847624
    • Stepanovic, S. Z., Potet, F., Petersen, C. I., Smith, J. A., Meiler, J., Balser, J. R., Kupershmidt, S. The evolutionarily conserved residue A653 plays a key role in HERG channel closing Journal of Physiology-London  2009 587:2555-2566  DOI:10.1113/jphysiol.2008.166694  PMID:19406877  PMCID:PMC2714020
    • Dong, E., Smith, J., Heinze, S., Alexander, N., Meiler, J. BCL::Align: sequence alignment and fold recognition with a custom scoring function online Gene  2008 422:41-46  DOI:10.1016/j.gene.2008.06.006  PMID:18601985  PMCID:PMC2658673
    • Kang, C., Tian, C., Sonnichsen, F. D., Smith, J. A., Meiler, J., George Jr., A. L., Vanoye, C. G., Kim, H. J., Sanders, C. R. Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel Biochemistry  2008 47:7999-8006  DOI:10.1021/bi800875q  PMID:18611041  PMCID:PMC2580054
    • Smith, J. A., Vanoye, C. G., George Jr., A. L., Meiler, J., Sanders, C. R. Structural models for the KCNQ1 voltage-gated potassium channel Biochemistry  2007 46:14141-14152  DOI:10.1021/bi701597s  PMID:17999538  PMCID:PMC2565492
    • Sherman, D. H., Li, S., Yermalitskaya, L. V., Kim, Y., Smith, J. A., Waterman, M. R., Podust, L. M. The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae Journal of Biological Chemistry  2006 281:26289-26297  DOI:10.1074/jbc.M605478200  PMID:16825192  PMCID:PMC2939096
    • Cho, Y. J., Wang, H., Kozekov, I. D., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Lloyd, R. S., Rizzo, C. J., Stone, M. P. Stereospecific formation of interstrand carbinolamine DNA cross-links by crotonaldehyde- and acetaldehyde-derived alpha-CH3-gamma-OH-1,N2-propano-2'-deoxyguanosine adducts in the 5'-CpG-3' sequence Chemical Research in Toxicology  2006 19:195-208  DOI:10.1021/tx050239z  PMID:16485895  PMCID:PMC2631444
    • Cho, Y. J., Wang, H., Kozekov, I. D., Kozekova, A., Kurtz, A. J., Jacob, J., Voehler, M., Smith, J., Harris, T. M., Rizzo, C. J., Lloyd, R. S., Stone, M. P. Orientation of the crotonaldehyde-derived N2-[3-Oxo-1(S)-methyl-propyl]-dG DNA adduct hinders interstrand cross-link formation in the 5'-CpG-3' sequence Chemical Research in Toxicology  2006 19:1019-1029  DOI:10.1021/tx0600604  PMID:16918240
    • Halasa, N. B., Whitlock, J. A., McCurley, T. L., Smith, J. A., Zhu, Q., Ochs, H., Dermody, T. S., Crowe Jr., J. E. Fatal hemophagocytic lymphohistiocytosis associated with Epstein-Barr virus infection in a patient with a novel mutation in the signaling lymphocytic activation molecule-associated protein Clinical Infectious Diseases  2003 37:E136-E141  DOI:10.1086/379126  PMID:14583885
    • Bassarello, C., Cimino, P., Bifulco, G., Boger, D. L., Smith, J. A., Chazin, W. J., Gomez-Paloma, L. NMR structure of the (+)-CPI-indole/d(GACTAATTGAC)-d(GTCAATTAGTC) covalent complex ChemBioChem  2003 4:1188-1193  DOI:10.1002/cbic.200300642  PMID:14613110
    • degree-related publication Smith, J. A., Bifulco, G., Case, D. A., Boger, D. L., Gomez-Paloma, L., Chazin, W. J. The structural basis for in situ activation of DNA alkylation by duocarmycin sa Journal of Molecular Biology  2000 300:1195-1204  DOI:10.1006/jmbi.2000.3887  PMID:10903864
    • degree-related publication Eis, P. S., Smith, J. A., Rydzewski, J. M., Case, D. A., Boger, D. L., Chazin, W. J. High resolution solution structure of a DNA duplex alkylated by the antitumor agent duocarmycin SA Journal of Molecular Biology  1997 272:237-252  DOI:10.1006/jmbi.1997.1223  PMID:9299351
    • degree-related publication Smith, J. A., Gomez-Paloma, L., Case, D. A., Chazin, W. J. Molecular dynamics docking driven by NMR-derived restraints to determine the structure of the calicheamicin γ1(I) oligosaccharide domain complexed to duplex DNA Magnetic Resonance in Chemistry  1996 34:S147-S155  DOI:10.1002/(SICI)1097-458X(199612)34:133.0.CO;2-0
    • degree-related publication Potts, B. C. M., Smith J., Akke, M., Macke, T. J., Okazaki, K., Hidaka, H., Case, D. A., Chazin, W. J. The structure of calcyclin reveals a novel homodimeric fold for S100 Ca2+-binding proteins Nature Structural Biology  1995 2:790-796  DOI:10.1038/nsb0995-790  PMID:7552751
    • degree-related publication Paloma, L. G., Smith, J. A., Chazin, W. J., Nicolaou, K. C. Interaction of calicheamicin with duplex DNA - role of the oligosaccharide domain and identification of multiple binding modes Journal of the American Chemical Society  1994 116:3697-3708  DOI:10.1021/ja00088a005
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Background

education and training

  • Ph.D. in Biology, Scripps Research 1992 - 1999
  • B.S. in Chemistry, University of California, Santa Barbara 1988 - 1992

advisee of

  • graduate advising relationship

    • Case, David A., Ph.D.  candidacy, 1993 - 1999
    • Chazin, Walter J., Ph.D.  candidacy, 1993 - 1999
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Contact

full name

  • Jarrod Anson Smith

geographic location

  • Scripps California 

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