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Siggins, George
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Siggins, George

Faculty Member Emeritus
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Positions

  • 2017 - Professor Emeritus, Neuroscience , Scripps Research
  • 2013 - 2017 Professor Emeritus, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 1983 - 2013 Professor, Molecular and Integrative Neurosciences (MIND) , Scripps Research
Dr. George Siggins uses extracellular, intracellular, and patch recording of neurons in vitro to study mechanisms of synaptic transmission and neuronal function and to understand the effects of neuropeptides, abused drugs, and neuropathologic insults.

Research Areas research areas

  • Alzheimer (UMLS)
  • Mental Illness (UMLS)

Contact

  • geobob@scripps.edu

Websites

  • George Siggins, Ph.D.
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Publications

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    • Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala Journal of Pharmacology and Experimental Therapeutics  2015 355:206-211  DOI:10.1124/jpet.115.225870  PMID:26350161  PMCID:PMC4613963
    • Bajo, M., Varodayan, F. P., Madamba, S. G., Roberts, A. J., Casal, L. M., Oleata, C. S., Siggins, G. R., Roberto, M. IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala Frontiers in Pharmacology  2015 6:49  DOI:10.3389/fphar.2015.00049  PMID:25852553  PMCID:PMC4365713
    • Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Kappa-opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites Journal of Pharmacology and Experimental Therapeutics  2013 346:130-137  DOI:10.1124/jpet.112.202903  PMID:23587526  PMCID:PMC3684840
    • Roberto, M., Gilpin, N. W., Siggins, G. R. The central amygdala and alcohol: Role of γ-aminobutyric acid, glutamate, and neuropeptides Cold Spring Harbor Perspectives in Medicine  2012 2:a012195  DOI:10.1101/cshperspect.a012195  PMID:23085848  PMCID:PMC3543070
    • Bajo, M., Madamba, S. G., Lu, X. Y., Sharkey, L. M., Bartfai, T., Siggins, G. R. Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala Addiction Biology  2012 17:694-705  DOI:10.1111/j.1369-1600.2011.00360.x  PMID:21955024  PMCID:PMC3252398
    • Bajo, M., Roberto, M., Madamba, S. G., Siggins, G. R. Neuroadaptation of gabaergic transmission in the central amygdala during chronic morphine treatment Addiction Biology  2011 16:551-564  DOI:10.1111/j.1369-1600.2010.00269.x  PMID:21182569  PMCID:PMC3117063
    • Cruz, M. T., Bajo, M., Maragnoli, M. E., Tabakoff, B., Siggins, G. R., Roberto, M. Type 7 adenylyl cyclase is involved in the ethanol and crf sensitivity of gabaergic synapses in mouse central amygdala Frontiers in Neuroscience  2011 4:207  DOI:10.3389/fnins.2010.00207  PMID:21258618  PMCID:PMC3024005
    • Roberto, M., Cruz, M., Bajo, M., Siggins, G. R., Parsons, L. H., Schweitzer, P. The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala Neuropsychopharmacology  2010 35:1962-1972  DOI:10.1038/npp.2010.70  PMID:20463657  PMCID:PMC2904853
    • Roberto, M., Cruz, M. T., Gilpin, N. W., Sabin, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., et al. Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence Biological Psychiatry  2010 67:831-839  DOI:10.1016/j.biopsych.2009.11.007  PMID:20060104  PMCID:PMC2883449
    • Silberman, Y., Bajo, M., Chappell, A. M., Christian, D. T., Cruz, M., Diaz, M. R., Kash, T., Lack, A. K., Messing, R. O., Siggins, G. R., Winder, D., Roberto, M., et al. Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions Alcohol  2009 43:509-519  DOI:10.1016/j.alcohol.2009.01.002  PMID:19913194  PMCID:PMC2814297
    • Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Roberto, M., Madamba, S. G., Siggins, G. R., Moore, S. D. Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: Lack of ethanol interactions Journal of Pharmacology and Experimental Therapeutics  2009 328:284-293  DOI:10.1124/jpet.108.140749  PMID:18854491  PMCID:PMC2685907
    • Nie, Z. G., Zorrilla, E. P., Madamba, S. G., Rice, K. C., Roberto, M., Siggins, G. R. Presynaptic crf(1) receptors mediate the ethanol enhancement of gabaergic transmission in the mouse central amygdala Thescientificworldjournal  2009 9:68-85  DOI:10.1100/tsw.2009.1  PMID:19151899  PMCID:PMC3053445
    • Bajo, M., Cruz, M. T., Siggins, G. R., Messing, R., Roberto, M. Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala Proceedings of the National Academy of Sciences of the United States of America  2008 105:8410-8415  DOI:10.1073/pnas.0802302105  PMID:18541912  PMCID:PMC2448850
    • Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., Koob, G. F. Cellular and behavioral interactions of gabapentin with alcohol dependence Journal of Neuroscience  2008 28:5762-5771  DOI:10.1523/jneurosci.0575-08.2008  PMID:18509038  PMCID:PMC2493536
    • Sharkey, L. M., Madamba, S. G., Siggins, G. R., Bartfai, T. Galanin alters gabaergic neurotransmission in the dorsal raphe nucleus Neurochemical Research  2008 33:285-291  DOI:10.1007/s11064-007-9524-5  PMID:17973188
    • Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Presynaptic delta opioid receptors regulate ethanol actions in central amygdala Journal of Pharmacology and Experimental Therapeutics  2007 320:917-925  DOI:10.1124/jpet.106.112722  PMID:17114568
    • Roberto, M., Siggins, G. R. Nociceptin/orphanin fq presynaptically decreases gabaergic transmission and blocks the ethanol-induced increase of gaba release in central amygdala Proceedings of the National Academy of Sciences of the United States of America  2006 103:9715-9720  DOI:10.1073/pnas.0601899103  PMID:16788074  PMCID:PMC1480472
    • Roberto, M., Bajo, M., Crawford, E., Madamba, S. G., Siggins, G. R. Chronic ethanol exposure and protracted abstinence alter nmda receptors in central amygdala Neuropsychopharmacology  2006 31:988-996  DOI:10.1038/sj.npp.1300840  PMID:16052
    • Breese, G. R., Criswell, H. E., Carta, M., Dodson, P. D., Hanchar, H. J., Khisti, R. T., Mameli, M., Ming, Z., Morrow, A. L., Olsen, R. W., Otis, T. S., Parsons, L. H., et al. Basis of the gabamimetic profile of ethanol Alcoholism-Clinical and Experimental Research  2006 30:731-744  DOI:10.1111/j.0145-6008.2006.00086.x  PMID:16573592  PMCID:PMC2958095
    • Bajo, M., Crawford, E. F., Roberto, M., Madamba, S. G., Siggins, G. R. Chronic morphine treatment alters expression of n-methyl-d-aspartate receptor subunits in the extended amygdala Journal of Neuroscience Research  2006 83:532-537  DOI:10.1002/jnr.20756  PMID:16453311
    • Roberto, M., Treistman, S. N., Pietrzykowski, A. Z., Weiner, J., Galindo, R., Mameli, M., Valenzuela, F., Zhu, P. J., Zhang, T. A., Lovinger, D., Hendricson, A. H., Morrisett, R. Actions of acute and chronic ethanol on presynaptic terminals Alcoholism-Clinical and Experimental Research  2006 30:222-232  DOI:10.1111/j.1530-0277.2006.00030.x  PMID:16441271  PMCID:PMC4115792
    • Tallent, M. K., Veronique, F., Qiu, C., Calbet, M., Lamp, T., Baratta, M. V., Suzuki, C., Levy, C. L., Siggins, G. R., Henriksen, S. J., Criado, J. R., Roberts, A., et al. Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning Molecular and Cellular Neuroscience  2005 30:465-475  DOI:10.1016/j.mcn.2005.08.010  PMID:16182561
    • Siggins, G. R., Roberto, M., Nie, Z. G. The tipsy terminal: Presynaptic effects of ethanol Pharmacology & Therapeutics  2005 107:80-98  DOI:10.1016/j.pharmathera.2005.01.006  PMID:15963352
    • Roberto, M., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Increased GABA release in the central amygdala of ethanol-dependent rats Journal of Neuroscience  2004 24:10159-10166  DOI:10.1523/jneurosci.3004-04.2004  PMID:15537886
    • Martin, G., Guadano-Ferraz, A., Morte, B., Ahmed, S., Koob, G. F., de Lecea, L., Siggins, G. R. Chronic morphine treatment alters n-methyl-d-aspartate receptors in freshly isolated neurons from nucleus accumbens Journal of Pharmacology and Experimental Therapeutics  2004 311:265-273  DOI:10.1124/jpet.104.067504  PMID:15263066
    • Schweitzer, P., Roberto, M., Madamba, S. G., Siggins, G. R. Gamma-hydroxybutyrate increases a potassium current and decreases the h-current in hippocampal neurons via gaba(b) receptors Journal of Pharmacology and Experimental Therapeutics  2004 311:172-179  DOI:10.1124/jpet.104.069534  PMID:15152029
    • Vlkolinsky, R., Siggins, G. R., Campbell, I. L., Krucker, T. Acute exposure to cxc chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices Journal of Neuroimmunology  2004 150:37-47  DOI:10.1016/j.jneuroim.2004.01.011  PMID:15081247
    • Nie, Z. G., Schweitzer, P., Roberts, A. J., Madamba, S. G., Moore, S. D., Siggins, G. R. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors Science  2004 303:1512-1514  DOI:10.1126/science.1092550  PMID:15001778
    • Roberto, M., Schweitzer, P., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis Journal of Neuroscience  2004 24:1594-1603  DOI:10.1523/jneurosci.5077-03.2004  PMID:14973247
    • Schweitzer, P., Madamba, S. G., Siggins, G. R. The sleep-modulating peptide cortistatin augments the h-current in hippocampal neurons Journal of Neuroscience  2003 23:10884-10891  PMID:14645483
    • Roberto, M., Madamba, S. G., Moore, S. D., Tallent, M. K., Siggins, G. R. Ethanol increases gabaergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons Proceedings of the National Academy of Sciences of the United States of America  2003 100:2053-2058  DOI:10.1073/pnas.0437926100  PMID:12566570  PMCID:PMC149957
    • Siggins, G. R., Martin, G., Roberto, M., Nie, Z. G., Madamba, S., De Lecea, L. Glutamatergic transmission in opiate and alcohol dependence Annals of the New York Academy of Sciences  2003 1003:196-211  DOI:10.1196/annals.1300.012  PMID:14684447
    • Martin, G., Siggins, G. R. Electrophysiological evidence for expression of glycine receptors in freshly isolated neurons from nucleus accumbens Journal of Pharmacology and Experimental Therapeutics  2002 302:1135-1145  DOI:10.1124/jpet.102.033399  PMID:12183673
    • Krucker, T., Siggins, G. R., McNamara, R. K., Lindsley, K. A., Dao, A., Allison, D. W., de Lecea, L., Lovenberg, T. W., Sutcliffe, J. G., Gerendasy, D. D. Targeted disruption of rc3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus Journal of Neuroscience  2002 22:5525-5535  PMID:12097504
    • Koob, G. F., Mason, B. J., De Witte, P., Littleton, J., Siggins, G. R. Potential neuroprotective effects of acamprosate Alcoholism-Clinical and Experimental Research  2002 26:586-592  DOI:10.1111/j.1530-0277.2002.tb02578.x  PMID:11981137
    • Martin, G., Fabre, W., Siggins, G. R., de Lecea, L. Interaction of the hypocretins with neurotransmitters in the nucleus accumbens Regulatory Peptides  2002 104:111-117  DOI:10.1016/s0167-0115(01)00354-8  PMID:11830285
    • Tallent, M. K., Madamba, S. G., Siggins, G. R. Nociceptin reduces epileptiform events in ca3 hippocampus via presynaptic and postsynaptic mechanisms Journal of Neuroscience  2001 21:6940-6948  PMID:11517281
    • Steffensen, S. C., Nie, Z. G., Criado, J. R., Siggins, G. R. Ethanol inhibition of n-methyl-d-aspartate responses involves presynaptic g-aminobutyric acid(b) receptors Journal of Pharmacology and Experimental Therapeutics  2000 294:637-647  PMID:10900243
    • Sanna, P. P., Berton, F., Cammalleri, M., Tallent, M. K., Siggins, G. R., Bloom, F. E., Francesconi, W. A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus Proceedings of the National Academy of Sciences of the United States of America  2000 97:8653-8657  DOI:10.1073/pnas.140219097  PMID:10890901  PMCID:PMC27003
    • Krucker, T., Siggins, G. R., Halpain, S. Dynamic actin filaments are required for stable long-term potentiation (ltp) in area ca1 of the hippocampus Proceedings of the National Academy of Sciences of the United States of America  2000 97:6856-6861  DOI:10.1073/pnas.100139797  PMID:10823894  PMCID:PMC18765
    • Nie, Z. G., Madamba, S. G., Siggins, G. R. Ethanol enhances gamma-aminobutyric acid responses in a subpopulation of nucleus accumbens neurons: Role of metabotropic glutamate receptors Journal of Pharmacology and Experimental Therapeutics  2000 293:654-661  PMID:10773041
    • Przewlocki, R., Parsons, K. L., Sweeney, D. D., Trotter, C., Netzeband, J. G., Siggins, G. R., Gruol, D. L. Opioid enhancement of calcium oscillations and burst events involving NMDA receptors and L-type calcium channels in cultured hippocampal neurons Journal of Neuroscience  1999 19:9705-9715  PMID:10559380
    • Martin, G., Ahmed, S. H., Blank, T., Spiess, J., Koob, G. F., Siggins, G. R. Chronic morphine treatment alters nmda receptor-mediated synaptic transmission in the nucleus accumbens Journal of Neuroscience  1999 19:9081-9089  PMID:10516325
    • Madamba, S. G., Schweitzer, P., Siggins, G. R. Dynorphin selectively augments the m-current in hippocampal ca1 neurons by an opiate receptor mechanism Journal of Neurophysiology  1999 82:1768-1775  PMID:10515966
    • Madamba, S. G., Schweitzer, P., Siggins, G. R. Nociceptin augments k+ currents in hippocampal ca1 neurons by both orl-1 and opiate receptor mechanisms Journal of Neurophysiology  1999 82:1776-1785  PMID:10515967
    • Campbell, I. L., Krucker, T., Steffensen, S., Akwa, Y., Powell, H. C., Lane, T. C., Carr, D. J., Gold, L. H., Henriksen, S. J., Siggins, G. R. Structural and functional neuropathology in transgenic mice with cns expression of ifn-alpha Brain Research  1999 835:46-61  DOI:10.1016/s0006-8993(99)01328-1  PMID:10448195
    • Tallent, M. K., Siggins, G. R. Somatostatin acts in cai and ca3 to reduce hippocampal epileptiform activity Journal of Neurophysiology  1999 81:1626-1635  PMID:10200199
    • Martin, G., Przewlocki, R., Siggins, G. R. Chronic morphine treatment selectively augments metabotropic glutamate receptor-induced inhibition of n-methyl-d-aspartate receptor-mediated neurotransmission in nucleus accumbens Journal of Pharmacology and Experimental Therapeutics  1999 288:30-35  PMID:9862749
    • Krucker, T., Toggas, S. M., Mucke, L., Siggins, G. R. Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in ca1 hippocampus Neuroscience  1998 83:691-700  DOI:10.1016/s0306-4522(97)00413-2  PMID:9483553
    • Schweitzer, P., Madamba, S. G., Siggins, G. R. Somatostatin increases a voltage-insensitive k+ conductance in rat ca1 hippocampal neurons Journal of Neurophysiology  1998 79:1230-1238  PMID:9497404
    • Berton, F., Francesconi, W. G., Madamba, S. G., Zieglgansberger, W., Siggins, G. R. Acamprosate enhances N-methyl-D-apartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons Alcoholism-Clinical and Experimental Research  1998 22:183-191  DOI:10.1097/00000374-199802000-00025  PMID:9514305
    • Martin, G., Nie, Z. G., Siggins, G. R. Metabotropic glutamate receptors regulate n-methyl-d-aspartate-mediated synaptic transmission in nucleus accumbens Journal of Neurophysiology  1997 78:3028-3038  PMID:9405522
    • Tallent, M. K., Siggins, G. R. Somatostatin depresses excitatory but not inhibitory neurotransmission in rat ca1 hippocampus Journal of Neurophysiology  1997 78:3008-3018  PMID:9405520
    • Martin, G., Nie, Z. G., Siggins, G. R. Mu-opioid receptors modulate nmda receptor-mediated responses in nucleus accumbens neurons Journal of Neuroscience  1997 17:11-22  PMID:8987732
    • Francesconi, W., Berton, F., Demuro, A., Madamba, S. G., Siggins, G. R. Naloxone blocks long-term depression of excitatory transmission in rat ca1 hippocampus in vitro Archives Italiennes de Biologie  1997 135:37-48  PMID:9139581
    • Madamba, S. G., Schweitzer, P., Zieglgansberger, W., Siggins, G. R. Acamprosate (calcium acetylhomotaurinate) enhances the n-methyl-d-aspartate component of excitatory neurotransmission in rat hippocampal ca1 neurons in vitro Alcoholism-Clinical and Experimental Research  1996 20:651-658  DOI:10.1111/j.1530-0277.1996.tb01667.x  PMID:8800380
    • deLecea, L., Criado, J. R., ProsperoGarcia, O., Gautvik, K. M., Schweitzer, P., Danielson, P. E., Dunlop, C. L. M., Siggins, G. R., Henriksen, S. J., Sutcliffe, J. G. A cortical neuropeptide with neuronal depressant and sleep-modulating properties Nature  1996 381:242-245  DOI:10.1038/381242a0  PMID:8622767
    • Wan, F. J., Berton, F., Madamba, S. G., Francesconi, W., Siggins, G. R. Low ethanol concentrations enhance gabaergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of gaba(b) receptors Proceedings of the National Academy of Sciences of the United States of America  1996 93:5049-5054  DOI:10.1073/pnas.93.10.5049  PMID:8643527
    • Lammers, C. H., Schweitzer, P., Facchinetti, P., Arrang, J. M., Madamba, S. G., Siggins, G. R., Piomelli, D. Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling Journal of Neurochemistry  1996 66:147-152  DOI:10.1046/j.1471-4159.1996.66010147.x  PMID:8522947
    • Gold, L. H., Heyser, C. J., Roberts, A. J., Henriksen, S. J., Steffensen, S. C., Siggins, G. R., Bellinger, F. P., Chiang, C. S., Powell, H. C., Masliah, E., Campbell, I. L. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice Advances in Experimental Medicine and Biology  1996 402:199-205  DOI:10.1007/978-1-4613-0407-4_26  PMID:8787661
    • Bellinger, F. P., Madamba, S. G., Campbell, I. L., Siggins, G. R. Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6 Neuroscience Letters  1995 198:95-98  DOI:10.1016/0304-3940(95)11976-4  PMID:8592650
    • Madamba, S. G., Hsu, M., Schweitzer, P., Siggins, G. R. Ethanol enhances muscarinic cholinergic neurotransmission in rat hippocampus in-vitro Brain Research  1995 685:21-32  DOI:10.1016/0006-8993(95)00393-5  PMID:7583249
    • Nie, Z. G., Madamba, S. G., Siggins, G. R. Ethanol inhibits glutamatergic neurotransmission in nucleus-accumbens neurons by multiple mechanisms Journal of Pharmacology and Experimental Therapeutics  1994 271:1566-1573  PMID:7527857
    • Moore, S. D., Madamba, S. G., Schweitzer, P., Siggins, G. R. Voltage-dependent effects of opioid-peptides on hippocampal ca3 pyramidal neurons in-vitro Journal of Neuroscience  1994 14:809-820  PMID:7905518
    • Bellinger, F. P., Madamba, S., Siggins, G. R. Interleukin-1-beta inhibits synaptic strength and long-term potentiation in the rat ca1 hippocampus Brain Research  1993 628:227-234  DOI:10.1016/0006-8993(93)90959-q  PMID:8313151
    • Nie, Z. G., Yuan, X. R., Madamba, S. G., Siggins, G. R. Ethanol decreases glutamatergic synaptic transmission in rat nucleus-accumbens in-vitro - naloxone reversal Journal of Pharmacology and Experimental Therapeutics  1993 266:1705-1712  PMID:8396641
    • Schweitzer, P., Madamba, S., Champagnat, J., Siggins, G. R. Somatostatin inhibition of hippocampal ca1 pyramidal neurons - mediation by arachidonic-acid and its metabolites Journal of Neuroscience  1993 13:2033-2049  PMID:8097529
    • Pontzer, N. J., Madamba, S., Siggins, G. R., Crews, F. T. Concentrations of carbachol stimulating phosphoinositide hydrolysis cause a sustained decrease in membrane-potential and firing rate - role of inositol and inositol polyphosphate 2nd messengers Brain Research  1992 597:189-199  DOI:10.1016/0006-8993(92)91474-s  PMID:1335346
    • Zeise, M. L., Madamba, S., Siggins, G. R. Interleukin-1-beta increases synaptic inhibition in rat hippocampal pyramidal neurons in vitro Regulatory Peptides  1992 39:1-7  DOI:10.1016/0167-0115(92)90002-c  PMID:1579655
    • Yuan, X. R., Madamba, S., Siggins, G. R. Opioid-peptides reduce synaptic transmission in the nucleus-accumbens Neuroscience Letters  1992 134:223-228  DOI:10.1016/0304-3940(92)90522-9  PMID:1317025
    • Schweitzer, P., Madamba, S., Siggins, G. R. Arachidonic-acid metabolites as mediators of somatostatin-induced increase of neuronal m-current Nature  1990 346:464-467  DOI:10.1038/346464a0  PMID:1974033
    • Moore, S. D., Madamba, S. G., Siggins, G. R. Ethanol diminishes a voltage-dependent k+ current, the m-current, in ca1 hippocampal pyramidal neurons in vitro Brain Research  1990 516:222-228  DOI:10.1016/0006-8993(90)90922-x  PMID:1973065
    • Joels, M., Madamba, S. G., Moore, S. D., Morrison, J. H., Siggins, G. R. Somatostatin immunohistochemistry of hippocampal slices with lucifer yellow-stained pyramidal neurons responding to somatostatin Regulatory Peptides  1990 28:215-221  DOI:10.1016/0167-0115(90)90019-s  PMID:1693006
    • Moore, S. D., Madamba, S. G., Zieglgansberger, W., Siggins, G. R. Enkephalin analogs depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro Neuroscience Letters  1988 91:71-76  DOI:10.1016/0304-3940(88)90251-0  PMID:3050621
    • Jacquin, T., Champagnat, J., Madamba, S., Denavitsaubie, M., Siggins, G. R. Somatostatin depresses excitability in neurons of the solitary tract complex through hyperpolarization and augmentation of im, a non-inactivating voltage-dependent outward current blocked by muscarinic agonists Proceedings of the National Academy of Sciences of the United States of America  1988 85:948-952  DOI:10.1073/pnas.85.3.948  PMID:2448787
    • Moore, S. D., Madamba, S. G., Joels, M., Siggins, G. R. Somatostatin augments the m-current in hippocampal-neurons Science  1988 239:278-280  DOI:10.1126/science.2892268  PMID:2892268
    • Staunton, D. A., Svensson, T. H., Chouvet, G. E., Siggins, G. R., Bloom, F. E. Systemic phenoxybenzamine but not beta-adrenergic antagonists block noradrenergic inhibition of cerebellar purkinje and hippocampal pyramidal neurons Journal of Neural Transmission  1988 73:101-113  DOI:10.1007/bf01243381  PMID:2905380
    • Bloom, F. E., Siggins, G. R. Electrophysiological action of ethanol at the cellular-level Alcohol  1987 4:331-337  DOI:10.1016/0741-8329(87)90031-0  PMID:3304331
    • Siggins, G. R., Pittman, Q. J., French, E. D. Effects of ethanol on ca-1 and ca-3 pyramidal cells in the hippocampal slice preparation - an intracellular study Brain Research  1987 414:22-34  DOI:10.1016/0006-8993(87)91323-0  PMID:3620923
    • Siggins, G. R., Bloom, F. E., French, E. D., Madamba, S. G., Mancillas, J., Pittman, Q. J., Rogers, J. Electrophysiology of ethanol on central neurons Annals of the New York Academy of Sciences  1987 492:350-366  DOI:10.1111/j.1749-6632.1987.tb48692.x  PMID:3474932
    • Rogers, J., Madamba, S. G., Staunton, D. A., Siggins, G. R. Ethanol increases single unit-activity in the inferior olivary nucleus Brain Research  1986 385:253-262  DOI:10.1016/0006-8993(86)91071-1  PMID:3779391
    • Mancillas, J. R., Siggins, G. R., Bloom, F. E. Somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex Proceedings of the National Academy of Sciences of the United States of America  1986 83:7518-7521  DOI:10.1073/pnas.83.19.7518  PMID:2876428
    • Mancillas, J. R., Siggins, G. R., Bloom, F. E. Systemic ethanol: selective enhancement of responses to acetylcholine and somatostatin in hippocampus Science  1986 231:161-163  DOI:10.1126/science.2867600  PMID:2867600
    • Ferron, A., Siggins, G. R., Bloom, F. E. Vasoactive intestinal polypeptide acts synergistically with norepinephrine to depress spontaneous discharge rate in cerebral cortical-neurons Proceedings of the National Academy of Sciences of the United States of America  1985 82:8810-8812  DOI:10.1073/pnas.82.24.8810  PMID:3866254
    • Siggins, G. R., Gruol, D., Aldenhoff, J., Pittman, Q. Electrophysiological actions of corticotropin-releasing factor in the central nervous-system Federation Proceedings  1985 44:237-242  PMID:3155696
    • Chavkin, C., Henriksen, S. J., Siggins, G. R., Bloom, F. E. Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-a and dynorphin-b may act on mu-receptors in the ca1 region Brain Research  1985 331:366-370  DOI:10.1016/0006-8993(85)91565-3  PMID:2859095
    • Champagnat, J., Siggins, G. R., Koda, L. Y., Denavitsaubie, M. Synaptic responses of neurons of the nucleus tractus solitarius in vitro Brain Research  1985 325:49-56  DOI:10.1016/0006-8993(85)90301-4  PMID:2983833
    • Aldenhoff, J. B., Gruol, D. L., Rivier, J., Vale, W., Siggins, G. R. Corticotropin releasing-factor decreases postburst hyperpolarizations and excites hippocampal-neurons Science  1983 221:875-877  DOI:10.1126/science.6603658  PMID:6603658
    • Gruol, D. L., Chavkin, C., Valentino, R. J., Siggins, G. R. Dynorphin-a alters the excitability of pyramidal neurons of the rat hippocampus in vitro Life Sciences  1983 33:533-536  DOI:10.1016/0024-3205(83)90558-1
    • Champagnat, J., Denavitsaubie, M., Siggins, G. R. Rhythmic neuronal activities in the nucleus of the tractus solitarius isolated in vitro Brain Research  1983 280:155-159  DOI:10.1016/0006-8993(83)91184-8  PMID:6652474
    • Schultz, J. E., Siggins, G. R., Turck, M., Bloom, F. E. Electrophysiological and biochemical comparison of the acute and chronic effects of lithium and tricyclic antidepressants Advances in Biochemical Psychopharmacology  1982 31:347-357  PMID:6282062
    • Berger, T., French, E. D., Siggins, G. R., Shier, W. T., Bloom, F. E. Ethanol and some tetrahydroisoquinolines alter the discharge of cortical and hippocampal-neurons - relationship to endogenous opioids Pharmacology, Biochemistry and Behavior  1982 17:813-821  DOI:10.1016/0091-3057(82)90365-3  PMID:7178189
    • Siggins, G. R., McGinty, J. F., Morrison, J. H., Pittman, Q. J., Zieglgansberger, W., Magistretti, P. J., Gruol, D. L. The role of neuropeptides in the hippocampal formation Advances in Biochemical Psychopharmacology  1982 33:413-422  PMID:6127004
    • Siggins, G. R., Schubert, P. Adenosine depression of hippocampal-neurons in vitro - an intracellular study of dose-dependent actions on synaptic and membrane-potentials Neuroscience Letters  1981 23:55-60  DOI:10.1016/0304-3940(81)90186-5  PMID:6262683
    • Schultz, J. E., Siggins, G. R., Schocker, F. W., Turck, M., Bloom, F. E. Effects of prolonged treatment with lithium and tricyclic anti-depressants on discharge frequency, norepinephrine responses and beta-receptor binding in rat cerebellum - electro-physiological and biochemical-comparison Journal of Pharmacology and Experimental Therapeutics  1981 216:28-38  PMID:6256526
    • Bloom, F. E., Siggins, G. R., Henriksen, S. J. Electrophysiologic assessment of receptor changes following chronic drug treatment Federation Proceedings  1981 40:166-172  PMID:6257556
    • Gruol, D. L., Siggins, G. R., Padjen, A. L., Forman, D. S. Explant cultures of adult amphibian sympathetic-ganglia - electro-physiological and pharmacological investigation of neurotransmitter and nucleotide action Brain Research  1981 223:81-106  DOI:10.1016/0006-8993(81)90808-8  PMID:6116525
    • Siggins, G. R., Zieglgansberger, W. Morphine and opioid-peptides reduce inhibitory synaptic potentials in hippocampal pyramidal cells-in vitro without alteration of membrane-potential Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  1981 78:5235-5239  DOI:10.1073/pnas.78.8.5235  PMID:6272296
    • Pittman, Q. J., Siggins, G. R. Somatostatin hyperpolarizes hippocampal pyramidal cells in vitro Brain Research  1981 221:402-408  DOI:10.1016/0006-8993(81)90791-5  PMID:6116516
    • Siggins, G. R., Bloom, F. E. Alcohol-related electrophysiology Pharmacology, Biochemistry and Behavior  1980 13:203-211  PMID:7017760
    • French, E. D., Siggins, G. R. An iontophoretic survey of opioid peptide actions in the rat limbic system - in search of opiate epileptogenic mechanisms Regulatory Peptides  1980 1:127-146  DOI:10.1016/0167-0115(80)90016-6  PMID:6265978
    • Rogers, J., Siggins, G. R., Schulman, J. A., Bloom, F. E. Physiological correlates of ethanol intoxication, tolerance, and dependence in rat cerebellar purkinje-cells Brain Research  1980 196:183-198  DOI:10.1016/0006-8993(80)90725-8  PMID:7190454
    • Siggins, G. R., Schultz, J. E. Chronic treatment with lithium or desipramine alters discharge frequency and norepinephrine responsiveness of cerebellar purkinje-cells Proceedings of the National Academy of Sciences of the United States of America  1979 76:5987-5991  DOI:10.1073/pnas.76.11.5987  PMID:230496
    • Siggins, G. R., Henriksen, S. J., Bloom, F. Iontophoresis of li+ antagonizes noradrenergic synaptic inhibition of rat cerebellar purkinje-cells Proceedings of the National Academy of Sciences of the United States of America  1979 76:3015-3018  DOI:10.1073/pnas.76.6.3015  PMID:288083
    • Taylor, D., Hoffer, B., Zieglgansberger, W., Siggins, G., Ling, N., Seiger, A., Olson, L. Opioid peptides excite pyramidal neurons and evoke epileptiform activity in hippocampal transplants inoculo Brain Research  1979 176:135-142  DOI:10.1016/0006-8993(79)90875-8  PMID:487169
    • Zieglgansberger, W., French, E. D., Siggins, G. R., Bloom, F. E. Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons Science  1979 205:415-417  DOI:10.1126/science.451610  PMID:451610
    • Forman, D. S., Padjen, A. L., Siggins, G. R. Axonal-transport of organelles visualized by light-microscopy - cinemicrographic and computer-analysis Brain Research  1977 136:197-213  DOI:10.1016/0006-8993(77)90798-3  PMID:72584
    • Forman, D. S., Padjen, A. L., Siggins, G. R. Effect of temperature on rapid retrograde transport of microscopically visible intra-axonal organelles Brain Research  1977 136:215-226  DOI:10.1016/0006-8993(77)90799-5  PMID:72585
    • Nicoll, R. A., Siggins, G. R., Ling, N., Bloom, F. E., Guillemin, R. Neuronal actions of endorphins and enkephalins among brain-regions - comparative microiontophoretic study Proceedings of the National Academy of Sciences of the United States of America  1977 74:2584-2588  DOI:10.1073/pnas.74.6.2584  PMID:267951
    • Siggins, G. R., Gruol, D. L., Padjen, A. L., Forman, D. S. Purine and pyrimidine mononucleotides depolarize neurons of explanted amphibian sympathetic-ganglia Nature  1977 270:263-265  DOI:10.1038/270263a0  PMID:201858
    • Siggins, G. R., Henriksen, S. J., Landis, S. C. Electrophysiology of purkinje neurons in weaver mouse - iontophoresis of neurotransmitters and cyclic nucleotides, and stimulation of nucleus locus coeruleus Brain Research  1976 114:53-69  DOI:10.1016/0006-8993(76)91007-6  PMID:183862
    • Siggins, G. R., Henriksen, S. J. Analogs of cyclic adenosine-monophosphate - correlation of inhibition of purkinje neurons with protein kinase activation Science  1975 189:559-561  DOI:10.1126/science.167439  PMID:167439
    • Shoemaker, W. J., Balentine, L. T., Siggins, G. R., Hoffer, B. J., Henriksen, S. J., Bloom, F. E. Characteristics of release of adenosine 3'-5' - monophosphate from micropipets by microiontophoresis Journal of Cyclic Nucleotide Research  1975 1:97-106  PMID:4474
    • Siggins, G. R., Hoffer, B. J., Ungerstedt, U. Electrophysiological evidence for involvement of cyclic adenosine monophosphate in dopamine responses of caudate neurons Life Sciences  1974 15:779-792  DOI:10.1016/0024-3205(74)90516-5  PMID:4378085
    • Bloom, F. E., Siggins, G. R., Hoffer, B. J. Interpreting failures to confirm depression of cerebellar purkinje-cells by cyclic-amp Science  1974 185:627-629  DOI:10.1126/science.185.4151.627  PMID:4366788
    • Hoffer, B. J., Siggins, G. R., Oliver, A. P., Bloom, F. E. Activation of pathway from locus coeruleus to rat cerebellar purkinje neurons - pharmacological evidence of noradrenergic central inhibition Journal of Pharmacology and Experimental Therapeutics  1973 184:553-569  PMID:4347049
    • Siggins, G. R., Forman, D. S. Degenerative effects of 6-aminodopamine and 6-hydroxydopamine on peripheral adrenergic nerves Zeitschrift für Zellforschung und Mikroskopische Anatomie  1973 146:339-349  DOI:10.1007/bf02346226  PMID:4544341
    • Siggins, G. R., Battenberg, E. F., Hoffer, B. J., Bloom, F. E., Steiner, A. L. Noradrenergic stimulation of cyclic adenosine monophosphate in rat purkinje neurons: An immunocytochemical study Science  1973 179:585-588  DOI:10.1126/science.179.4073.585  PMID:4346826
    • Bloom, F. E., Hoffer, B. J., Battenberg, E. R., Siggins, G. R., Steiner, A. L., Parker, C. W., Wedner, H. J. Adenosine 3',5'-monophosphate is localized in cerebellar neurons: Immunofluorescence evidence Science  1972 177:436-438  DOI:10.1126/science.177.4047.436  PMID:4339615
    • Hoffer, B. J., Siggins, G. R., Oliver, A. P., Bloom, F. E. Cyclic AMP-mediated adrenergic synapses to cerebellar Purkinje cells Advances in Cyclic Nucleotide Research  1972 1:411-423  PMID:4353180
    • Bloom, F. E., Barker, J. L., Hoffer, B. J., Siggins, G. R., Nicoll, R. A. Effects of serotonin on central neurons: Microiontophoretic administration Federation Proceedings  1972 31:97-106  PMID:4333253
    • Bloom, F. E., Hoffer, B. J., Siggins, G. R. Norepinephrine mediated cerebellar synapses: A model system for neuropsychopharmacology Biological Psychiatry  1972 4:157-177  PMID:4337435
    • Siggins, G. R., Hoffer, B. J., Oliver, A. P., Bloom, F. E. Activation of a central noradrenergic projection to cerebellum Nature  1971 233:481-483  DOI:10.1038/233481a0  PMID:4939543
    • Godfraind, J. M., Pumain, R., Siggins, G. R., Hoffer, B. J., Bloom, F. E. Cyclic adenosine monophosphate and norepinephrine: Effect on purkinje cells in rat cerebellar cortex Science  1971 174:1257-1259  PMID:4332286
    • Siggins, G. R., Oliver, A. P., Hoffer, B. J., Bloom, F. E. Cyclic adenosine monophosphate and norepinephrine: Effects on transmembrane properties of cerebellar purkinje cells Science  1971 171:192-194  DOI:10.1126/science.171.3967.192  PMID:4322158
    • Hoffer, B. J., Siggins, G. R., Oliver, A. P., Bloom, F. E. Cyclic amp mediation of norepinephrine inhibition in rat cerebellar cortex: A unique class of synaptic responses Annals of the New York Academy of Sciences  1971 185:531-549  PMID:4330518
    • Siggins, G. R., Weitsen, H. A. Cytochemical and physiological evidence for cholinergic, neurogenic vasodilation of amphibian arterioles and precapillary sphincters. I. Light microscopy Microvascular Research  1971 3:308-322  DOI:10.1016/0026-2862(71)90056-2  PMID:4106944
    • Woodward, D. J., Hoffer, B. J., Siggins, G. R., Oliver, A. P. Inhibition of purkinje cells in the frog cerebellum. Ii. Evidence for gaba as the inhibitory transmitter Brain Research  1971 33:91-100  DOI:10.1016/0006-8993(71)90308-8  PMID:4330216
    • Hoffer, B. J., Neff, N. H., Siggins, G. R. Microiontophoretic release of norepinephrine from micropipettes Neuropharmacology  1971 10:175-180  DOI:10.1016/0028-3908(71)90038-4  PMID:5093958
    • Siggins, G., Hoffer, B., Bloom, F. Prostaglandin-norepinephrine interactions in brain: Microelectrophoretic and histochemical correlates Annals of the New York Academy of Sciences  1971 180:302-323  DOI:10.1111/j.1749-6632.1971.tb53199.x  PMID:5286100
    • Hoffer, B. J., Siggins, G. R., Woodward, D. J., Bloom, F. E. Spontaneous discharge of purkinje neurons after destruction of catecholamine-containing afferents by 6-hydroxydopamine Brain Research  1971 30:425-430  DOI:10.1016/0006-8993(71)90095-3  PMID:4329214
    • Bloom, F. E., Hoffer, B. J., Siggins, G. R. Studies on norepinephrine-containing afferents to purkinje cells of art cerebellum. I. Localization of the fibers and their synapses Brain Research  1971 25:501-521  DOI:10.1016/0006-8993(71)90457-4  PMID:5544323
    • Siggins, G. R., Hoffer, B. J., Bloom, F. E. Studies on norepinephrine-containing afferents to purkinje cells of rat cerebellum. 3. Evidence for mediation of norepinephrine effects by cyclic 3',5'-adenosine monophosphate Brain Research  1971 25:535-553  DOI:10.1016/0006-8993(71)90459-8  PMID:4322679
    • Hoffer, B. J., Siggins, G. R., Bloom, F. E. Studies on norepinephrine-containing afferents to purkinje cells of rat cerebellum. Ii. Sensitivity of purkinje cells to norepinephrine and related substances administered by microiontophoresis Brain Research  1971 25:523-534  DOI:10.1016/0006-8993(71)90458-6  PMID:4395919
    • Woodward, D. J., Hoffer, B. J., Siggins, G. R., Bloom, F. E. The ontogenetic development of synaptic junctions, synaptic activation and responsiveness to neurotransmitter substances in rat cerebellar purkinje cells Brain Research  1971 34:73-97  DOI:10.1016/0006-8993(71)90352-0  PMID:4330971
    • Siggins, G. R., Bloom, F. E. Cytochemical and physiological effects of 6-hydroxydopamine on periarteriolar nerves of frogs Circulation Research  1970 27:23-38  PMID:5424564
    • Siggins, G. R., Hoffer, B. J., Bloom, F. E. Cyclic adenosine monophosphate: Possible mediator for norepinephrine effects on cerebellar purkinje cells Science  1969 165:1018-1020  DOI:10.1126/science.165.3897.1018  PMID:4308638
    • Hoffer, B. J., Siggins, G. R., Bloom, F. E. Prostaglandins e1 and e2 antagonize norepinephrine effects on cerebellar purkinje cells: Microelectrophoretic study Science  1969 166:1418-1420  DOI:10.1126/science.166.3911.1418  PMID:5350346

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Research

research overview

  • Central Synaptic Communication: Neuropeptides, Abused Drugs and Neuropathology

    For the past 19 years, our electrophysiology laboratory has sought to understand mechanisms of neuronal function and synaptic communication and the effects of neuropeptides, abused drugs and neuropathological insults on these mechanisms , using extracellular, intracellular and patch recording of neurons in vitro brain slice and freshly-isolated neuronal preparations. We administer drugs, transmitters, cytokines and neurotoxins by superfusion and from micropipettes, and we activate synaptic transmission via stimulating electrodes. The neuropeptides under study include somatostatin, cortistatin, various opioid peptides, nociceptin and neuropeptide Y. These peptides generally have inhibitory actions on central neurons, although with different profiles of actions with respect to neuron type. In addition, several of these peptides have anti-epileptic properties. We also investigate the action and function of several cytokines such as IL-1, IL-6, interferons, and the effects on neuronal function of several neuropathological insults, including those thought to cause dementias, such as beta amyloid and the HIV coat protein gp-120.
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Background

education and training

  • Ph.D. in Biology, Boston University 1976
  • A.B. in Biology, Harvard University 1960
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Contact

full name

  • George R. Siggins

geographic location

  • Scripps California 

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