recent publications
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academic article
- Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Interaction of CRF and kappa opioid systems on GABAergic neurotransmission in the mouse central amygdala Journal of Pharmacology and Experimental Therapeutics 2015 355:206-211 DOI:10.1124/jpet.115.225870 PMID:26350161 PMCID:PMC4613963
- Bajo, M., Varodayan, F. P., Madamba, S. G., Roberts, A. J., Casal, L. M., Oleata, C. S., Siggins, G. R., Roberto, M. IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala Frontiers in Pharmacology 2015 6:49 DOI:10.3389/fphar.2015.00049 PMID:25852553 PMCID:PMC4365713
- Kang-Park, M., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Kappa-opioid receptors in the central amygdala regulate ethanol actions at presynaptic GABAergic sites Journal of Pharmacology and Experimental Therapeutics 2013 346:130-137 DOI:10.1124/jpet.112.202903 PMID:23587526 PMCID:PMC3684840
- Roberto, M., Gilpin, N. W., Siggins, G. R. The central amygdala and alcohol: Role of γ-aminobutyric acid, glutamate, and neuropeptides Cold Spring Harbor Perspectives in Medicine 2012 2:a012195 DOI:10.1101/cshperspect.a012195 PMID:23085848 PMCID:PMC3543070
- Bajo, M., Madamba, S. G., Lu, X. Y., Sharkey, L. M., Bartfai, T., Siggins, G. R. Receptor subtype-dependent galanin actions on gamma-aminobutyric acidergic neurotransmission and ethanol responses in the central amygdala Addiction Biology 2012 17:694-705 DOI:10.1111/j.1369-1600.2011.00360.x PMID:21955024 PMCID:PMC3252398
- Bajo, M., Roberto, M., Madamba, S. G., Siggins, G. R. Neuroadaptation of gabaergic transmission in the central amygdala during chronic morphine treatment Addiction Biology 2011 16:551-564 DOI:10.1111/j.1369-1600.2010.00269.x PMID:21182569 PMCID:PMC3117063
- Cruz, M. T., Bajo, M., Maragnoli, M. E., Tabakoff, B., Siggins, G. R., Roberto, M. Type 7 adenylyl cyclase is involved in the ethanol and crf sensitivity of gabaergic synapses in mouse central amygdala Frontiers in Neuroscience 2011 4:207 DOI:10.3389/fnins.2010.00207 PMID:21258618 PMCID:PMC3024005
- Roberto, M., Cruz, M., Bajo, M., Siggins, G. R., Parsons, L. H., Schweitzer, P. The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala Neuropsychopharmacology 2010 35:1962-1972 DOI:10.1038/npp.2010.70 PMID:20463657 PMCID:PMC2904853
- Roberto, M., Cruz, M. T., Gilpin, N. W., Sabin, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., et al. Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence Biological Psychiatry 2010 67:831-839 DOI:10.1016/j.biopsych.2009.11.007 PMID:20060104 PMCID:PMC2883449
- Silberman, Y., Bajo, M., Chappell, A. M., Christian, D. T., Cruz, M., Diaz, M. R., Kash, T., Lack, A. K., Messing, R. O., Siggins, G. R., Winder, D., Roberto, M., et al. Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions Alcohol 2009 43:509-519 DOI:10.1016/j.alcohol.2009.01.002 PMID:19913194 PMCID:PMC2814297
- Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Roberto, M., Madamba, S. G., Siggins, G. R., Moore, S. D. Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: Lack of ethanol interactions Journal of Pharmacology and Experimental Therapeutics 2009 328:284-293 DOI:10.1124/jpet.108.140749 PMID:18854491 PMCID:PMC2685907
- Nie, Z. G., Zorrilla, E. P., Madamba, S. G., Rice, K. C., Roberto, M., Siggins, G. R. Presynaptic crf(1) receptors mediate the ethanol enhancement of gabaergic transmission in the mouse central amygdala Thescientificworldjournal 2009 9:68-85 DOI:10.1100/tsw.2009.1 PMID:19151899 PMCID:PMC3053445
- Bajo, M., Cruz, M. T., Siggins, G. R., Messing, R., Roberto, M. Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala Proceedings of the National Academy of Sciences of the United States of America 2008 105:8410-8415 DOI:10.1073/pnas.0802302105 PMID:18541912 PMCID:PMC2448850
- Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., Koob, G. F. Cellular and behavioral interactions of gabapentin with alcohol dependence Journal of Neuroscience 2008 28:5762-5771 DOI:10.1523/jneurosci.0575-08.2008 PMID:18509038 PMCID:PMC2493536
- Sharkey, L. M., Madamba, S. G., Siggins, G. R., Bartfai, T. Galanin alters gabaergic neurotransmission in the dorsal raphe nucleus Neurochemical Research 2008 33:285-291 DOI:10.1007/s11064-007-9524-5 PMID:17973188
- Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Siggins, G. R., Moore, S. D. Presynaptic delta opioid receptors regulate ethanol actions in central amygdala Journal of Pharmacology and Experimental Therapeutics 2007 320:917-925 DOI:10.1124/jpet.106.112722 PMID:17114568
- Roberto, M., Siggins, G. R. Nociceptin/orphanin fq presynaptically decreases gabaergic transmission and blocks the ethanol-induced increase of gaba release in central amygdala Proceedings of the National Academy of Sciences of the United States of America 2006 103:9715-9720 DOI:10.1073/pnas.0601899103 PMID:16788074 PMCID:PMC1480472
- Roberto, M., Bajo, M., Crawford, E., Madamba, S. G., Siggins, G. R. Chronic ethanol exposure and protracted abstinence alter nmda receptors in central amygdala Neuropsychopharmacology 2006 31:988-996 DOI:10.1038/sj.npp.1300840 PMID:16052
- Breese, G. R., Criswell, H. E., Carta, M., Dodson, P. D., Hanchar, H. J., Khisti, R. T., Mameli, M., Ming, Z., Morrow, A. L., Olsen, R. W., Otis, T. S., Parsons, L. H., et al. Basis of the gabamimetic profile of ethanol Alcoholism-Clinical and Experimental Research 2006 30:731-744 DOI:10.1111/j.0145-6008.2006.00086.x PMID:16573592 PMCID:PMC2958095
- Bajo, M., Crawford, E. F., Roberto, M., Madamba, S. G., Siggins, G. R. Chronic morphine treatment alters expression of n-methyl-d-aspartate receptor subunits in the extended amygdala Journal of Neuroscience Research 2006 83:532-537 DOI:10.1002/jnr.20756 PMID:16453311
- Roberto, M., Treistman, S. N., Pietrzykowski, A. Z., Weiner, J., Galindo, R., Mameli, M., Valenzuela, F., Zhu, P. J., Zhang, T. A., Lovinger, D., Hendricson, A. H., Morrisett, R. Actions of acute and chronic ethanol on presynaptic terminals Alcoholism-Clinical and Experimental Research 2006 30:222-232 DOI:10.1111/j.1530-0277.2006.00030.x PMID:16441271 PMCID:PMC4115792
- Tallent, M. K., Veronique, F., Qiu, C., Calbet, M., Lamp, T., Baratta, M. V., Suzuki, C., Levy, C. L., Siggins, G. R., Henriksen, S. J., Criado, J. R., Roberts, A., et al. Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning Molecular and Cellular Neuroscience 2005 30:465-475 DOI:10.1016/j.mcn.2005.08.010 PMID:16182561
- Siggins, G. R., Roberto, M., Nie, Z. G. The tipsy terminal: Presynaptic effects of ethanol Pharmacology & Therapeutics 2005 107:80-98 DOI:10.1016/j.pharmathera.2005.01.006 PMID:15963352
- Roberto, M., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Increased GABA release in the central amygdala of ethanol-dependent rats Journal of Neuroscience 2004 24:10159-10166 DOI:10.1523/jneurosci.3004-04.2004 PMID:15537886
- Martin, G., Guadano-Ferraz, A., Morte, B., Ahmed, S., Koob, G. F., de Lecea, L., Siggins, G. R. Chronic morphine treatment alters n-methyl-d-aspartate receptors in freshly isolated neurons from nucleus accumbens Journal of Pharmacology and Experimental Therapeutics 2004 311:265-273 DOI:10.1124/jpet.104.067504 PMID:15263066
- Schweitzer, P., Roberto, M., Madamba, S. G., Siggins, G. R. Gamma-hydroxybutyrate increases a potassium current and decreases the h-current in hippocampal neurons via gaba(b) receptors Journal of Pharmacology and Experimental Therapeutics 2004 311:172-179 DOI:10.1124/jpet.104.069534 PMID:15152029
- Vlkolinsky, R., Siggins, G. R., Campbell, I. L., Krucker, T. Acute exposure to cxc chemokine ligand 10, but not its chronic astroglial production, alters synaptic plasticity in mouse hippocampal slices Journal of Neuroimmunology 2004 150:37-47 DOI:10.1016/j.jneuroim.2004.01.011 PMID:15081247
- Nie, Z. G., Schweitzer, P., Roberts, A. J., Madamba, S. G., Moore, S. D., Siggins, G. R. Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors Science 2004 303:1512-1514 DOI:10.1126/science.1092550 PMID:15001778
- Roberto, M., Schweitzer, P., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis Journal of Neuroscience 2004 24:1594-1603 DOI:10.1523/jneurosci.5077-03.2004 PMID:14973247
- Schweitzer, P., Madamba, S. G., Siggins, G. R. The sleep-modulating peptide cortistatin augments the h-current in hippocampal neurons Journal of Neuroscience 2003 23:10884-10891 PMID:14645483
- Roberto, M., Madamba, S. G., Moore, S. D., Tallent, M. K., Siggins, G. R. Ethanol increases gabaergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons Proceedings of the National Academy of Sciences of the United States of America 2003 100:2053-2058 DOI:10.1073/pnas.0437926100 PMID:12566570 PMCID:PMC149957
- Siggins, G. R., Martin, G., Roberto, M., Nie, Z. G., Madamba, S., De Lecea, L. Glutamatergic transmission in opiate and alcohol dependence Annals of the New York Academy of Sciences 2003 1003:196-211 DOI:10.1196/annals.1300.012 PMID:14684447
- Martin, G., Siggins, G. R. Electrophysiological evidence for expression of glycine receptors in freshly isolated neurons from nucleus accumbens Journal of Pharmacology and Experimental Therapeutics 2002 302:1135-1145 DOI:10.1124/jpet.102.033399 PMID:12183673
- Krucker, T., Siggins, G. R., McNamara, R. K., Lindsley, K. A., Dao, A., Allison, D. W., de Lecea, L., Lovenberg, T. W., Sutcliffe, J. G., Gerendasy, D. D. Targeted disruption of rc3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus Journal of Neuroscience 2002 22:5525-5535 PMID:12097504
- Koob, G. F., Mason, B. J., De Witte, P., Littleton, J., Siggins, G. R. Potential neuroprotective effects of acamprosate Alcoholism-Clinical and Experimental Research 2002 26:586-592 DOI:10.1111/j.1530-0277.2002.tb02578.x PMID:11981137
- Martin, G., Fabre, W., Siggins, G. R., de Lecea, L. Interaction of the hypocretins with neurotransmitters in the nucleus accumbens Regulatory Peptides 2002 104:111-117 DOI:10.1016/s0167-0115(01)00354-8 PMID:11830285
- Tallent, M. K., Madamba, S. G., Siggins, G. R. Nociceptin reduces epileptiform events in ca3 hippocampus via presynaptic and postsynaptic mechanisms Journal of Neuroscience 2001 21:6940-6948 PMID:11517281
- Steffensen, S. C., Nie, Z. G., Criado, J. R., Siggins, G. R. Ethanol inhibition of n-methyl-d-aspartate responses involves presynaptic g-aminobutyric acid(b) receptors Journal of Pharmacology and Experimental Therapeutics 2000 294:637-647 PMID:10900243
- Sanna, P. P., Berton, F., Cammalleri, M., Tallent, M. K., Siggins, G. R., Bloom, F. E., Francesconi, W. A role for Src kinase in spontaneous epileptiform activity in the CA3 region of the hippocampus Proceedings of the National Academy of Sciences of the United States of America 2000 97:8653-8657 DOI:10.1073/pnas.140219097 PMID:10890901 PMCID:PMC27003
- Krucker, T., Siggins, G. R., Halpain, S. Dynamic actin filaments are required for stable long-term potentiation (ltp) in area ca1 of the hippocampus Proceedings of the National Academy of Sciences of the United States of America 2000 97:6856-6861 DOI:10.1073/pnas.100139797 PMID:10823894 PMCID:PMC18765
- Nie, Z. G., Madamba, S. G., Siggins, G. R. Ethanol enhances gamma-aminobutyric acid responses in a subpopulation of nucleus accumbens neurons: Role of metabotropic glutamate receptors Journal of Pharmacology and Experimental Therapeutics 2000 293:654-661 PMID:10773041
- Przewlocki, R., Parsons, K. L., Sweeney, D. D., Trotter, C., Netzeband, J. G., Siggins, G. R., Gruol, D. L. Opioid enhancement of calcium oscillations and burst events involving NMDA receptors and L-type calcium channels in cultured hippocampal neurons Journal of Neuroscience 1999 19:9705-9715 PMID:10559380
- Martin, G., Ahmed, S. H., Blank, T., Spiess, J., Koob, G. F., Siggins, G. R. Chronic morphine treatment alters nmda receptor-mediated synaptic transmission in the nucleus accumbens Journal of Neuroscience 1999 19:9081-9089 PMID:10516325
- Madamba, S. G., Schweitzer, P., Siggins, G. R. Dynorphin selectively augments the m-current in hippocampal ca1 neurons by an opiate receptor mechanism Journal of Neurophysiology 1999 82:1768-1775 PMID:10515966
- Madamba, S. G., Schweitzer, P., Siggins, G. R. Nociceptin augments k+ currents in hippocampal ca1 neurons by both orl-1 and opiate receptor mechanisms Journal of Neurophysiology 1999 82:1776-1785 PMID:10515967
- Campbell, I. L., Krucker, T., Steffensen, S., Akwa, Y., Powell, H. C., Lane, T. C., Carr, D. J., Gold, L. H., Henriksen, S. J., Siggins, G. R. Structural and functional neuropathology in transgenic mice with cns expression of ifn-alpha Brain Research 1999 835:46-61 DOI:10.1016/s0006-8993(99)01328-1 PMID:10448195
- Tallent, M. K., Siggins, G. R. Somatostatin acts in cai and ca3 to reduce hippocampal epileptiform activity Journal of Neurophysiology 1999 81:1626-1635 PMID:10200199
- Martin, G., Przewlocki, R., Siggins, G. R. Chronic morphine treatment selectively augments metabotropic glutamate receptor-induced inhibition of n-methyl-d-aspartate receptor-mediated neurotransmission in nucleus accumbens Journal of Pharmacology and Experimental Therapeutics 1999 288:30-35 PMID:9862749
- Krucker, T., Toggas, S. M., Mucke, L., Siggins, G. R. Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in ca1 hippocampus Neuroscience 1998 83:691-700 DOI:10.1016/s0306-4522(97)00413-2 PMID:9483553
- Schweitzer, P., Madamba, S. G., Siggins, G. R. Somatostatin increases a voltage-insensitive k+ conductance in rat ca1 hippocampal neurons Journal of Neurophysiology 1998 79:1230-1238 PMID:9497404
- Berton, F., Francesconi, W. G., Madamba, S. G., Zieglgansberger, W., Siggins, G. R. Acamprosate enhances N-methyl-D-apartate receptor-mediated neurotransmission but inhibits presynaptic GABA(B) receptors in nucleus accumbens neurons Alcoholism-Clinical and Experimental Research 1998 22:183-191 DOI:10.1097/00000374-199802000-00025 PMID:9514305
- Martin, G., Nie, Z. G., Siggins, G. R. Metabotropic glutamate receptors regulate n-methyl-d-aspartate-mediated synaptic transmission in nucleus accumbens Journal of Neurophysiology 1997 78:3028-3038 PMID:9405522
- Tallent, M. K., Siggins, G. R. Somatostatin depresses excitatory but not inhibitory neurotransmission in rat ca1 hippocampus Journal of Neurophysiology 1997 78:3008-3018 PMID:9405520
- Martin, G., Nie, Z. G., Siggins, G. R. Mu-opioid receptors modulate nmda receptor-mediated responses in nucleus accumbens neurons Journal of Neuroscience 1997 17:11-22 PMID:8987732
- Francesconi, W., Berton, F., Demuro, A., Madamba, S. G., Siggins, G. R. Naloxone blocks long-term depression of excitatory transmission in rat ca1 hippocampus in vitro Archives Italiennes de Biologie 1997 135:37-48 PMID:9139581
- Madamba, S. G., Schweitzer, P., Zieglgansberger, W., Siggins, G. R. Acamprosate (calcium acetylhomotaurinate) enhances the n-methyl-d-aspartate component of excitatory neurotransmission in rat hippocampal ca1 neurons in vitro Alcoholism-Clinical and Experimental Research 1996 20:651-658 DOI:10.1111/j.1530-0277.1996.tb01667.x PMID:8800380
- deLecea, L., Criado, J. R., ProsperoGarcia, O., Gautvik, K. M., Schweitzer, P., Danielson, P. E., Dunlop, C. L. M., Siggins, G. R., Henriksen, S. J., Sutcliffe, J. G. A cortical neuropeptide with neuronal depressant and sleep-modulating properties Nature 1996 381:242-245 DOI:10.1038/381242a0 PMID:8622767
- Wan, F. J., Berton, F., Madamba, S. G., Francesconi, W., Siggins, G. R. Low ethanol concentrations enhance gabaergic inhibitory postsynaptic potentials in hippocampal pyramidal neurons only after block of gaba(b) receptors Proceedings of the National Academy of Sciences of the United States of America 1996 93:5049-5054 DOI:10.1073/pnas.93.10.5049 PMID:8643527
- Lammers, C. H., Schweitzer, P., Facchinetti, P., Arrang, J. M., Madamba, S. G., Siggins, G. R., Piomelli, D. Arachidonate 5-lipoxygenase and its activating protein: prominent hippocampal expression and role in somatostatin signaling Journal of Neurochemistry 1996 66:147-152 DOI:10.1046/j.1471-4159.1996.66010147.x PMID:8522947
- Gold, L. H., Heyser, C. J., Roberts, A. J., Henriksen, S. J., Steffensen, S. C., Siggins, G. R., Bellinger, F. P., Chiang, C. S., Powell, H. C., Masliah, E., Campbell, I. L. Behavioral and neurophysiological effects of CNS expression of cytokines in transgenic mice Advances in Experimental Medicine and Biology 1996 402:199-205 DOI:10.1007/978-1-4613-0407-4_26 PMID:8787661
- Bellinger, F. P., Madamba, S. G., Campbell, I. L., Siggins, G. R. Reduced long-term potentiation in the dentate gyrus of transgenic mice with cerebral overexpression of interleukin-6 Neuroscience Letters 1995 198:95-98 DOI:10.1016/0304-3940(95)11976-4 PMID:8592650
- Madamba, S. G., Hsu, M., Schweitzer, P., Siggins, G. R. Ethanol enhances muscarinic cholinergic neurotransmission in rat hippocampus in-vitro Brain Research 1995 685:21-32 DOI:10.1016/0006-8993(95)00393-5 PMID:7583249
- Nie, Z. G., Madamba, S. G., Siggins, G. R. Ethanol inhibits glutamatergic neurotransmission in nucleus-accumbens neurons by multiple mechanisms Journal of Pharmacology and Experimental Therapeutics 1994 271:1566-1573 PMID:7527857
- Moore, S. D., Madamba, S. G., Schweitzer, P., Siggins, G. R. Voltage-dependent effects of opioid-peptides on hippocampal ca3 pyramidal neurons in-vitro Journal of Neuroscience 1994 14:809-820 PMID:7905518
- Bellinger, F. P., Madamba, S., Siggins, G. R. Interleukin-1-beta inhibits synaptic strength and long-term potentiation in the rat ca1 hippocampus Brain Research 1993 628:227-234 DOI:10.1016/0006-8993(93)90959-q PMID:8313151
- Nie, Z. G., Yuan, X. R., Madamba, S. G., Siggins, G. R. Ethanol decreases glutamatergic synaptic transmission in rat nucleus-accumbens in-vitro - naloxone reversal Journal of Pharmacology and Experimental Therapeutics 1993 266:1705-1712 PMID:8396641
- Schweitzer, P., Madamba, S., Champagnat, J., Siggins, G. R. Somatostatin inhibition of hippocampal ca1 pyramidal neurons - mediation by arachidonic-acid and its metabolites Journal of Neuroscience 1993 13:2033-2049 PMID:8097529
- Pontzer, N. J., Madamba, S., Siggins, G. R., Crews, F. T. Concentrations of carbachol stimulating phosphoinositide hydrolysis cause a sustained decrease in membrane-potential and firing rate - role of inositol and inositol polyphosphate 2nd messengers Brain Research 1992 597:189-199 DOI:10.1016/0006-8993(92)91474-s PMID:1335346
- Zeise, M. L., Madamba, S., Siggins, G. R. Interleukin-1-beta increases synaptic inhibition in rat hippocampal pyramidal neurons in vitro Regulatory Peptides 1992 39:1-7 DOI:10.1016/0167-0115(92)90002-c PMID:1579655
- Yuan, X. R., Madamba, S., Siggins, G. R. Opioid-peptides reduce synaptic transmission in the nucleus-accumbens Neuroscience Letters 1992 134:223-228 DOI:10.1016/0304-3940(92)90522-9 PMID:1317025
- Schweitzer, P., Madamba, S., Siggins, G. R. Arachidonic-acid metabolites as mediators of somatostatin-induced increase of neuronal m-current Nature 1990 346:464-467 DOI:10.1038/346464a0 PMID:1974033
- Moore, S. D., Madamba, S. G., Siggins, G. R. Ethanol diminishes a voltage-dependent k+ current, the m-current, in ca1 hippocampal pyramidal neurons in vitro Brain Research 1990 516:222-228 DOI:10.1016/0006-8993(90)90922-x PMID:1973065
- Joels, M., Madamba, S. G., Moore, S. D., Morrison, J. H., Siggins, G. R. Somatostatin immunohistochemistry of hippocampal slices with lucifer yellow-stained pyramidal neurons responding to somatostatin Regulatory Peptides 1990 28:215-221 DOI:10.1016/0167-0115(90)90019-s PMID:1693006
- Moore, S. D., Madamba, S. G., Zieglgansberger, W., Siggins, G. R. Enkephalin analogs depress synaptic potentials in rat dentate granule cells recorded intracellularly in vitro Neuroscience Letters 1988 91:71-76 DOI:10.1016/0304-3940(88)90251-0 PMID:3050621
- Jacquin, T., Champagnat, J., Madamba, S., Denavitsaubie, M., Siggins, G. R. Somatostatin depresses excitability in neurons of the solitary tract complex through hyperpolarization and augmentation of im, a non-inactivating voltage-dependent outward current blocked by muscarinic agonists Proceedings of the National Academy of Sciences of the United States of America 1988 85:948-952 DOI:10.1073/pnas.85.3.948 PMID:2448787
- Moore, S. D., Madamba, S. G., Joels, M., Siggins, G. R. Somatostatin augments the m-current in hippocampal-neurons Science 1988 239:278-280 DOI:10.1126/science.2892268 PMID:2892268
- Staunton, D. A., Svensson, T. H., Chouvet, G. E., Siggins, G. R., Bloom, F. E. Systemic phenoxybenzamine but not beta-adrenergic antagonists block noradrenergic inhibition of cerebellar purkinje and hippocampal pyramidal neurons Journal of Neural Transmission 1988 73:101-113 DOI:10.1007/bf01243381 PMID:2905380
- Bloom, F. E., Siggins, G. R. Electrophysiological action of ethanol at the cellular-level Alcohol 1987 4:331-337 DOI:10.1016/0741-8329(87)90031-0 PMID:3304331
- Siggins, G. R., Pittman, Q. J., French, E. D. Effects of ethanol on ca-1 and ca-3 pyramidal cells in the hippocampal slice preparation - an intracellular study Brain Research 1987 414:22-34 DOI:10.1016/0006-8993(87)91323-0 PMID:3620923
- Siggins, G. R., Bloom, F. E., French, E. D., Madamba, S. G., Mancillas, J., Pittman, Q. J., Rogers, J. Electrophysiology of ethanol on central neurons Annals of the New York Academy of Sciences 1987 492:350-366 DOI:10.1111/j.1749-6632.1987.tb48692.x PMID:3474932
- Rogers, J., Madamba, S. G., Staunton, D. A., Siggins, G. R. Ethanol increases single unit-activity in the inferior olivary nucleus Brain Research 1986 385:253-262 DOI:10.1016/0006-8993(86)91071-1 PMID:3779391
- Mancillas, J. R., Siggins, G. R., Bloom, F. E. Somatostatin selectively enhances acetylcholine-induced excitations in rat hippocampus and cortex Proceedings of the National Academy of Sciences of the United States of America 1986 83:7518-7521 DOI:10.1073/pnas.83.19.7518 PMID:2876428
- Mancillas, J. R., Siggins, G. R., Bloom, F. E. Systemic ethanol: selective enhancement of responses to acetylcholine and somatostatin in hippocampus Science 1986 231:161-163 DOI:10.1126/science.2867600 PMID:2867600
- Ferron, A., Siggins, G. R., Bloom, F. E. Vasoactive intestinal polypeptide acts synergistically with norepinephrine to depress spontaneous discharge rate in cerebral cortical-neurons Proceedings of the National Academy of Sciences of the United States of America 1985 82:8810-8812 DOI:10.1073/pnas.82.24.8810 PMID:3866254
- Siggins, G. R., Gruol, D., Aldenhoff, J., Pittman, Q. Electrophysiological actions of corticotropin-releasing factor in the central nervous-system Federation Proceedings 1985 44:237-242 PMID:3155696
- Chavkin, C., Henriksen, S. J., Siggins, G. R., Bloom, F. E. Selective inactivation of opioid receptors in rat hippocampus demonstrates that dynorphin-a and dynorphin-b may act on mu-receptors in the ca1 region Brain Research 1985 331:366-370 DOI:10.1016/0006-8993(85)91565-3 PMID:2859095
- Champagnat, J., Siggins, G. R., Koda, L. Y., Denavitsaubie, M. Synaptic responses of neurons of the nucleus tractus solitarius in vitro Brain Research 1985 325:49-56 DOI:10.1016/0006-8993(85)90301-4 PMID:2983833
- Aldenhoff, J. B., Gruol, D. L., Rivier, J., Vale, W., Siggins, G. R. Corticotropin releasing-factor decreases postburst hyperpolarizations and excites hippocampal-neurons Science 1983 221:875-877 DOI:10.1126/science.6603658 PMID:6603658
- Gruol, D. L., Chavkin, C., Valentino, R. J., Siggins, G. R. Dynorphin-a alters the excitability of pyramidal neurons of the rat hippocampus in vitro Life Sciences 1983 33:533-536 DOI:10.1016/0024-3205(83)90558-1
- Champagnat, J., Denavitsaubie, M., Siggins, G. R. Rhythmic neuronal activities in the nucleus of the tractus solitarius isolated in vitro Brain Research 1983 280:155-159 DOI:10.1016/0006-8993(83)91184-8 PMID:6652474
- Schultz, J. E., Siggins, G. R., Turck, M., Bloom, F. E. Electrophysiological and biochemical comparison of the acute and chronic effects of lithium and tricyclic antidepressants Advances in Biochemical Psychopharmacology 1982 31:347-357 PMID:6282062
- Berger, T., French, E. D., Siggins, G. R., Shier, W. T., Bloom, F. E. Ethanol and some tetrahydroisoquinolines alter the discharge of cortical and hippocampal-neurons - relationship to endogenous opioids Pharmacology, Biochemistry and Behavior 1982 17:813-821 DOI:10.1016/0091-3057(82)90365-3 PMID:7178189
- Siggins, G. R., McGinty, J. F., Morrison, J. H., Pittman, Q. J., Zieglgansberger, W., Magistretti, P. J., Gruol, D. L. The role of neuropeptides in the hippocampal formation Advances in Biochemical Psychopharmacology 1982 33:413-422 PMID:6127004
- Siggins, G. R., Schubert, P. Adenosine depression of hippocampal-neurons in vitro - an intracellular study of dose-dependent actions on synaptic and membrane-potentials Neuroscience Letters 1981 23:55-60 DOI:10.1016/0304-3940(81)90186-5 PMID:6262683
- Schultz, J. E., Siggins, G. R., Schocker, F. W., Turck, M., Bloom, F. E. Effects of prolonged treatment with lithium and tricyclic anti-depressants on discharge frequency, norepinephrine responses and beta-receptor binding in rat cerebellum - electro-physiological and biochemical-comparison Journal of Pharmacology and Experimental Therapeutics 1981 216:28-38 PMID:6256526
- Bloom, F. E., Siggins, G. R., Henriksen, S. J. Electrophysiologic assessment of receptor changes following chronic drug treatment Federation Proceedings 1981 40:166-172 PMID:6257556
- Gruol, D. L., Siggins, G. R., Padjen, A. L., Forman, D. S. Explant cultures of adult amphibian sympathetic-ganglia - electro-physiological and pharmacological investigation of neurotransmitter and nucleotide action Brain Research 1981 223:81-106 DOI:10.1016/0006-8993(81)90808-8 PMID:6116525
- Siggins, G. R., Zieglgansberger, W. Morphine and opioid-peptides reduce inhibitory synaptic potentials in hippocampal pyramidal cells-in vitro without alteration of membrane-potential Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 1981 78:5235-5239 DOI:10.1073/pnas.78.8.5235 PMID:6272296
- Pittman, Q. J., Siggins, G. R. Somatostatin hyperpolarizes hippocampal pyramidal cells in vitro Brain Research 1981 221:402-408 DOI:10.1016/0006-8993(81)90791-5 PMID:6116516
- Siggins, G. R., Bloom, F. E. Alcohol-related electrophysiology Pharmacology, Biochemistry and Behavior 1980 13:203-211 PMID:7017760
- French, E. D., Siggins, G. R. An iontophoretic survey of opioid peptide actions in the rat limbic system - in search of opiate epileptogenic mechanisms Regulatory Peptides 1980 1:127-146 DOI:10.1016/0167-0115(80)90016-6 PMID:6265978
- Rogers, J., Siggins, G. R., Schulman, J. A., Bloom, F. E. Physiological correlates of ethanol intoxication, tolerance, and dependence in rat cerebellar purkinje-cells Brain Research 1980 196:183-198 DOI:10.1016/0006-8993(80)90725-8 PMID:7190454
- Siggins, G. R., Schultz, J. E. Chronic treatment with lithium or desipramine alters discharge frequency and norepinephrine responsiveness of cerebellar purkinje-cells Proceedings of the National Academy of Sciences of the United States of America 1979 76:5987-5991 DOI:10.1073/pnas.76.11.5987 PMID:230496
- Siggins, G. R., Henriksen, S. J., Bloom, F. Iontophoresis of li+ antagonizes noradrenergic synaptic inhibition of rat cerebellar purkinje-cells Proceedings of the National Academy of Sciences of the United States of America 1979 76:3015-3018 DOI:10.1073/pnas.76.6.3015 PMID:288083
- Taylor, D., Hoffer, B., Zieglgansberger, W., Siggins, G., Ling, N., Seiger, A., Olson, L. Opioid peptides excite pyramidal neurons and evoke epileptiform activity in hippocampal transplants inoculo Brain Research 1979 176:135-142 DOI:10.1016/0006-8993(79)90875-8 PMID:487169
- Zieglgansberger, W., French, E. D., Siggins, G. R., Bloom, F. E. Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons Science 1979 205:415-417 DOI:10.1126/science.451610 PMID:451610
- Forman, D. S., Padjen, A. L., Siggins, G. R. Axonal-transport of organelles visualized by light-microscopy - cinemicrographic and computer-analysis Brain Research 1977 136:197-213 DOI:10.1016/0006-8993(77)90798-3 PMID:72584
- Forman, D. S., Padjen, A. L., Siggins, G. R. Effect of temperature on rapid retrograde transport of microscopically visible intra-axonal organelles Brain Research 1977 136:215-226 DOI:10.1016/0006-8993(77)90799-5 PMID:72585
- Nicoll, R. A., Siggins, G. R., Ling, N., Bloom, F. E., Guillemin, R. Neuronal actions of endorphins and enkephalins among brain-regions - comparative microiontophoretic study Proceedings of the National Academy of Sciences of the United States of America 1977 74:2584-2588 DOI:10.1073/pnas.74.6.2584 PMID:267951
- Siggins, G. R., Gruol, D. L., Padjen, A. L., Forman, D. S. Purine and pyrimidine mononucleotides depolarize neurons of explanted amphibian sympathetic-ganglia Nature 1977 270:263-265 DOI:10.1038/270263a0 PMID:201858
- Siggins, G. R., Henriksen, S. J., Landis, S. C. Electrophysiology of purkinje neurons in weaver mouse - iontophoresis of neurotransmitters and cyclic nucleotides, and stimulation of nucleus locus coeruleus Brain Research 1976 114:53-69 DOI:10.1016/0006-8993(76)91007-6 PMID:183862
- Siggins, G. R., Henriksen, S. J. Analogs of cyclic adenosine-monophosphate - correlation of inhibition of purkinje neurons with protein kinase activation Science 1975 189:559-561 DOI:10.1126/science.167439 PMID:167439
- Shoemaker, W. J., Balentine, L. T., Siggins, G. R., Hoffer, B. J., Henriksen, S. J., Bloom, F. E. Characteristics of release of adenosine 3'-5' - monophosphate from micropipets by microiontophoresis Journal of Cyclic Nucleotide Research 1975 1:97-106 PMID:4474
- Siggins, G. R., Hoffer, B. J., Ungerstedt, U. Electrophysiological evidence for involvement of cyclic adenosine monophosphate in dopamine responses of caudate neurons Life Sciences 1974 15:779-792 DOI:10.1016/0024-3205(74)90516-5 PMID:4378085
- Bloom, F. E., Siggins, G. R., Hoffer, B. J. Interpreting failures to confirm depression of cerebellar purkinje-cells by cyclic-amp Science 1974 185:627-629 DOI:10.1126/science.185.4151.627 PMID:4366788
- Hoffer, B. J., Siggins, G. R., Oliver, A. P., Bloom, F. E. Activation of pathway from locus coeruleus to rat cerebellar purkinje neurons - pharmacological evidence of noradrenergic central inhibition Journal of Pharmacology and Experimental Therapeutics 1973 184:553-569 PMID:4347049
- Siggins, G. R., Forman, D. S. Degenerative effects of 6-aminodopamine and 6-hydroxydopamine on peripheral adrenergic nerves Zeitschrift für Zellforschung und Mikroskopische Anatomie 1973 146:339-349 DOI:10.1007/bf02346226 PMID:4544341
- Siggins, G. R., Battenberg, E. F., Hoffer, B. J., Bloom, F. E., Steiner, A. L. Noradrenergic stimulation of cyclic adenosine monophosphate in rat purkinje neurons: An immunocytochemical study Science 1973 179:585-588 DOI:10.1126/science.179.4073.585 PMID:4346826
- Bloom, F. E., Hoffer, B. J., Battenberg, E. R., Siggins, G. R., Steiner, A. L., Parker, C. W., Wedner, H. J. Adenosine 3',5'-monophosphate is localized in cerebellar neurons: Immunofluorescence evidence Science 1972 177:436-438 DOI:10.1126/science.177.4047.436 PMID:4339615
- Hoffer, B. J., Siggins, G. R., Oliver, A. P., Bloom, F. E. Cyclic AMP-mediated adrenergic synapses to cerebellar Purkinje cells Advances in Cyclic Nucleotide Research 1972 1:411-423 PMID:4353180
- Bloom, F. E., Barker, J. L., Hoffer, B. J., Siggins, G. R., Nicoll, R. A. Effects of serotonin on central neurons: Microiontophoretic administration Federation Proceedings 1972 31:97-106 PMID:4333253
- Bloom, F. E., Hoffer, B. J., Siggins, G. R. Norepinephrine mediated cerebellar synapses: A model system for neuropsychopharmacology Biological Psychiatry 1972 4:157-177 PMID:4337435
- Siggins, G. R., Hoffer, B. J., Oliver, A. P., Bloom, F. E. Activation of a central noradrenergic projection to cerebellum Nature 1971 233:481-483 DOI:10.1038/233481a0 PMID:4939543
- Godfraind, J. M., Pumain, R., Siggins, G. R., Hoffer, B. J., Bloom, F. E. Cyclic adenosine monophosphate and norepinephrine: Effect on purkinje cells in rat cerebellar cortex Science 1971 174:1257-1259 PMID:4332286
- Siggins, G. R., Oliver, A. P., Hoffer, B. J., Bloom, F. E. Cyclic adenosine monophosphate and norepinephrine: Effects on transmembrane properties of cerebellar purkinje cells Science 1971 171:192-194 DOI:10.1126/science.171.3967.192 PMID:4322158
- Hoffer, B. J., Siggins, G. R., Oliver, A. P., Bloom, F. E. Cyclic amp mediation of norepinephrine inhibition in rat cerebellar cortex: A unique class of synaptic responses Annals of the New York Academy of Sciences 1971 185:531-549 PMID:4330518
- Siggins, G. R., Weitsen, H. A. Cytochemical and physiological evidence for cholinergic, neurogenic vasodilation of amphibian arterioles and precapillary sphincters. I. Light microscopy Microvascular Research 1971 3:308-322 DOI:10.1016/0026-2862(71)90056-2 PMID:4106944
- Woodward, D. J., Hoffer, B. J., Siggins, G. R., Oliver, A. P. Inhibition of purkinje cells in the frog cerebellum. Ii. Evidence for gaba as the inhibitory transmitter Brain Research 1971 33:91-100 DOI:10.1016/0006-8993(71)90308-8 PMID:4330216
- Hoffer, B. J., Neff, N. H., Siggins, G. R. Microiontophoretic release of norepinephrine from micropipettes Neuropharmacology 1971 10:175-180 DOI:10.1016/0028-3908(71)90038-4 PMID:5093958
- Siggins, G., Hoffer, B., Bloom, F. Prostaglandin-norepinephrine interactions in brain: Microelectrophoretic and histochemical correlates Annals of the New York Academy of Sciences 1971 180:302-323 DOI:10.1111/j.1749-6632.1971.tb53199.x PMID:5286100
- Hoffer, B. J., Siggins, G. R., Woodward, D. J., Bloom, F. E. Spontaneous discharge of purkinje neurons after destruction of catecholamine-containing afferents by 6-hydroxydopamine Brain Research 1971 30:425-430 DOI:10.1016/0006-8993(71)90095-3 PMID:4329214
- Bloom, F. E., Hoffer, B. J., Siggins, G. R. Studies on norepinephrine-containing afferents to purkinje cells of art cerebellum. I. Localization of the fibers and their synapses Brain Research 1971 25:501-521 DOI:10.1016/0006-8993(71)90457-4 PMID:5544323
- Siggins, G. R., Hoffer, B. J., Bloom, F. E. Studies on norepinephrine-containing afferents to purkinje cells of rat cerebellum. 3. Evidence for mediation of norepinephrine effects by cyclic 3',5'-adenosine monophosphate Brain Research 1971 25:535-553 DOI:10.1016/0006-8993(71)90459-8 PMID:4322679
- Hoffer, B. J., Siggins, G. R., Bloom, F. E. Studies on norepinephrine-containing afferents to purkinje cells of rat cerebellum. Ii. Sensitivity of purkinje cells to norepinephrine and related substances administered by microiontophoresis Brain Research 1971 25:523-534 DOI:10.1016/0006-8993(71)90458-6 PMID:4395919
- Woodward, D. J., Hoffer, B. J., Siggins, G. R., Bloom, F. E. The ontogenetic development of synaptic junctions, synaptic activation and responsiveness to neurotransmitter substances in rat cerebellar purkinje cells Brain Research 1971 34:73-97 DOI:10.1016/0006-8993(71)90352-0 PMID:4330971
- Siggins, G. R., Bloom, F. E. Cytochemical and physiological effects of 6-hydroxydopamine on periarteriolar nerves of frogs Circulation Research 1970 27:23-38 PMID:5424564
- Siggins, G. R., Hoffer, B. J., Bloom, F. E. Cyclic adenosine monophosphate: Possible mediator for norepinephrine effects on cerebellar purkinje cells Science 1969 165:1018-1020 DOI:10.1126/science.165.3897.1018 PMID:4308638
- Hoffer, B. J., Siggins, G. R., Bloom, F. E. Prostaglandins e1 and e2 antagonize norepinephrine effects on cerebellar purkinje cells: Microelectrophoretic study Science 1969 166:1418-1420 DOI:10.1126/science.166.3911.1418 PMID:5350346