recent publications
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academic article
- Matos, J. L. M., Green, S. A., Chun, Y. G., Dang, V. Q., Dushin, R. G., Richardson, P., Chen, J. S., Piotrowski, D. W., Paegel, B. M., Shenvi, R. A. Cycloisomerization of Olefins in Water Angewandte Chemie-International Edition 2020 DOI:10.1002/anie.202003948 PMID:32285542
- Crossley, S. W. M., Tong, G. H., Lambrecht, M. J., Burdge, H. E., Shenvi, R. A. Synthesis of (-)-Picrotoxinin by Late-Stage Strong Bond Activation Journal of the American Chemical Society 2020 142:11376-11381 DOI:10.1021/jacs.0c05042 PMID:32573211
- Huffman, B. J., Chen, S., Schwarz, J. L., Plata, R. E., Chin, E. N., Lairson, L. L., Houk, K. N., Shenvi, R. A. Electronic complementarity permits hindered butenolide heterodimerization and discovery of novel cGAS/STING pathway antagonists Nature Chemistry 2020 12:310-317 DOI:10.1038/s41557-019-0413-8 PMID:32042135
- Tong, G. H., Baker, M. A., Shenvi, R. A. Change the channel: CysLoop receptor antagonists from nature Pest Management Science 2020 DOI:10.1002/ps.6166 PMID:33135373
- Hill, S. J., Brion, Aucm, Shenvi, R. A. Chemical syntheses of the salvinorin chemotype of KOR agonist Natural Product Reports 2020 37:1478-1496 DOI:10.1039/d0np00028k PMID:32808003 PMCID:PMC7677207
- Demoret, R. M., Baker, M. A., Ohtawa, M., Chen, S. M., Lam, C. C., Khom, S., Roberto, M., Forli, S., Houk, K. N., Shenvi, R. A. Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (-)-Bilobalide Journal of the American Chemical Society 2020 142:18599-18618 DOI:10.1021/jacs.0c08231 PMID:32991152 PMCID:PMC7727090
- Baker, M. A.*, Demoret, R. M.*, Ohtawa, M., Shenvi, R. A. Concise asymmetric synthesis of (-)-bilobalide Nature 2019 575:643-646 DOI:10.1038/s41586-019-1690-5 PMID:31618759 (* = equal contribution)
- Flood, D. T., Asai, S., Zhang, X., Wang, J., Yoon, L., Adams, Z. C., Dillingham, B. C., Sanchez, B. B., Vantourout, J. C., Flanagan, M. E., Piotrowsld, D. W., Richardson, P., et al. Expanding reactivity in DNA-encoded library synthesis via reversible binding of DNA to an inert quaternary ammonium support Journal of the American Chemical Society 2019 141:9998-10006 DOI:10.1021/jacs.9b03774 PMID:31136164
- Martinez, R. M., Burdge, H. E., Shenvi, R. A. Reanalysis of lindenatriene, a building block for the synthesis of lindenane oligomers Tetrahedron 2019 75:3140-3144 DOI:10.1016/j.tet.2019.03.011
- Green, S. A., Huffman, T. R., McCourt, R. O., van der Puyl, V., Shenvi, R. A. Hydroalkylation of olefins to form quaternary carbons Journal of the American Chemical Society 2019 141:7709-7714 DOI:10.1021/jacs.9b02844 PMID:31030508
- Huffman, B. J., Shenvi, R. A. Natural products in the "marketplace": Interfacing synthesis and biology Journal of the American Chemical Society 2019 141:3332-3346 DOI:10.1021/jacs.8b11297 PMID:30682249
- Huffman, T. R., Wu, Y., Emmerich, A., Shenvi, R. A. Intermolecular Heck Coupling with Hindered Alkenes Directed by Potassium Carboxylates Angewandte Chemie-International Edition 2019 58:2371-2376 DOI:10.1002/anie.201813233 PMID:30602064 PMCID:PMC6370521
- Shenvi, R. A., Rodriguez, R., Seitz, O. Tetrahedron Young Investigator Awards Angewandte Chemie-International Edition 2019 58:663-663 DOI:10.1002/anie.201812944
- Matos, J. L. M., Vasquez-Cespedes, S., Gu, J., Oguma, T., Shenvi, R. A. Branch-selective addition of unactivated olefins into imines and aldehydes Journal of the American Chemical Society 2018 140:16976-16981 DOI:10.1021/jacs.8b11699 PMID:30463404
- Green, S. A., Crossley, S. W. M., Matos, J. L. M., Vasquez-Cespedes, S., Shevick, S. L., Shenvi, R. A. The high chemofidelity of metal-catalyzed hydrogen atom transfer Accounts of Chemical Research 2018 51:2628-2640 DOI:10.1021/acs.accounts.8b00337 PMID:30406655 PMCID:PMC6248883
- Shevick, S. L., Obradors, C., Shenvi, R. A. Mechanistic interrogation of Co/Ni-dual catalyzed hydroarylation Journal of the American Chemical Society 2018 140:12056-12068 DOI:10.1021/jacs.8b06458 PMID:30153002
- Green, S. A., Vasquez-Cespedes, S., Shenvi, R. A. Iron-nickel dual-catalysis: a new engine for olefin functionalization and the formation of quaternary centers Journal of the American Chemical Society 2018 140:11317-11324 DOI:10.1021/jacs.8b05868 PMID:30048124
- Hirasawa, S., Cho, M., Brust, T. F., Roach, J. J., Bohn, L. M., Shenvi, R. A. O6C-20-nor-salvinorin A is a stable and potent KOR agonist Bioorganic & Medicinal Chemistry Letters 2018 28:2770-2772 DOI:10.1016/j.bmcl.2018.01.055 PMID:29426768 PMCID:PMC6067998
- Witkin, J. M., Shenvi, R. A., Li, X., Gleason, S. D., Weiss, J., Morrow, D., Catow, J. T., Wakulchik, M., Ohtawa, M., Lu, H. H., Martinez, M. D., Schkeryantz, J. M., et al. Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide reveals a non-convulsant signature and potential for progression in neurodegenerative disease studies Biochemical Pharmacology 2018 155:61-70 DOI:10.1016/j.bcp.2018.06.022 PMID:29940173 PMCID:PMC6135676
- Roach, J. J., Shenvi, R. A. A review of salvinorin analogs and their kappa-opioid receptor activity Bioorganic & Medicinal Chemistry Letters 2018 28:1436-1445 DOI:10.1016/j.bmcl.2018.03.029 PMID:29615341 PMCID:PMC5912166
- Lambrecht, M. J., Kelly, J. W., Shenvi, R. A. Mechanism of action of the cytotoxic asmarine alkaloids ACS Chemical Biology 2018 13:1299-1306 DOI:10.1021/acschembio.8b00096 PMID:29653046 PMCID:PMC5959788
- Roach, J. J., Sasano, Y., Schmid, C. L., Zaidi, S., Katritch, V., Stevens, R. C., Bohn, L. M., Shenvi, R. A. Dynamic strategic bond analysis yields a ten-step synthesis of 20-nor-salvinorin A, a potent κ-OR agonist ACS Central Science 2017 3:1329-1336 DOI:10.1021/acscentsci.7b00488 PMID:29296674 PMCID:PMC5746855
- Ohtawa, M., Krambis, M. J., Cerne, R., Schkeryantz, J. M., Witkin, J. M., Shenvi, R. A. Synthesis of (-)-11-O-debenzoyltashironin: neurotrophic sesquiterpenes cause hyperexcitation Journal of the American Chemical Society 2017 139:9637-9644 DOI:10.1021/jacs.7b04206 PMID:28644021
- Reiher, C. A., Shenvi, R. A. Stereocontrolled synthesis of kalihinol C Journal of the American Chemical Society 2017 139:3647-3650 DOI:10.1021/jacs.7b01124 PMID:28252949
- Green, S. A., Matos, J. L. M., Yagi, A., Shenvi, R. A. Branch-selective hydroarylation: iodoarene-olefin cross-coupling Journal of the American Chemical Society 2016 138:12779-12782 DOI:10.1021/jacs.6b08507 PMID:27623023
- Crossley, S. W. M., Obradors, C., Martinez, R. M., Shenvi, R. A. Mn-, Fe-, and Co-catalyzed radical hydrofunctionalizations of olefins Chemical Reviews 2016 116:8912-9000 DOI:10.1021/acs.chemrev.6b00334 PMID:27461578
- Tada, N., Jansen, D. J., Mower, M. P., Blewett, M. M., Umotoy, J. C., Cravatt, B. F., Wolan, D. W., Shenvi, R. A. Synthesis and sulfur electrophilicity of the Nuphar thiaspirane pharmacophore ACS Central Science 2016 2:401-408 DOI:10.1021/acscentsci.6b00113 PMID:27413784 PMCID:PMC4919772
- Lu, H. H., Pronin, S. V., Antonova-Koch, Y., Meister, S., Winzeler, E. A., Shenvi, R. A. Synthesis of (+)-7,20-diisocyanoadociane and liver -stage antiplasmodial activity of the isocyanoterpene class Journal of the American Chemical Society 2016 138:7268-7271 DOI:10.1021/jacs.6b03899 PMID:27244042
- Crossley, S. W. M., Martinez, R. M., Guevara-Zuluaga, S., Shenvi, R. A. Synthesis of the privileged 8-arylmenthol class by radical arylation of isopulegol Organic Letters 2016 18:2620-2623 DOI:10.1021/acs.orglett.6b01047 PMID:27175746
- Wan, K. K., Shenvi, R. A. Conjuring a supernatural product - DelMarine Synlett 2016 27:1145-1164 DOI:10.1055/s-0035-1561329
- Obradors, C., Martinez, R. M., Shenvi, R. A. Ph(i-PrO)SiH2: An exceptional reductant for metal-catalyzed hydrogen atom transfers Journal of the American Chemical Society 2016 138:4962-4971 DOI:10.1021/jacs.6b02032 PMID:26984323 PMCID:PMC4858193
- Shenvi, R. A. Cluster preface: Reinventing radical reactions Synlett 2016 27:678-679 DOI:10.1055/s-0035-1561221
- Shenvi, R. A. Neurite outgrowth enhancement by jiadifenolide: possible targets Natural Product Reports 2016 33:535-539 DOI:10.1039/c5np00160a PMID:26891462
- Tabor, M. G., Shenvi, R. A. Synthesis of lepadiformine using a hydroamination transform Organic Letters 2015 17:5776-5779 DOI:10.1021/acs.orglett.5b02992 PMID:26584132
- Crossley, S. W. M., Shenvi, R. A. A longitudinal study of alkaloid synthesis reveals functional group interconversions as bad actors Chemical Reviews 2015 115:9465-9531 DOI:10.1021/acs.chemrev.5b00154 PMID:26158529
- Lu, H. H., Martinez, M. D., Shenvi, R. A. An eight-step gram-scale synthesis of (-)-jiadifenolide Nature Chemistry 2015 7:604-607 DOI:10.1038/nchem.2283 PMID:26100810
- Roach, J. J., Shenvi, R. A. Supramolecular catalysis: Terpenes in tight spaces Nature Chemistry 2015 7:187-189 DOI:10.1038/nchem.2191 PMID:25698322
- Wan, K. K., Iwasaki, K., Umotoy, J. C., Wolan, D. W., Shenvi, R. A. Nitrosopurines en route to potently cytotoxic asmarines Angewandte Chemie-International Edition 2015 54:2410-2415 DOI:10.1002/anie.201411493 PMID:25580910 PMCID:PMC4470469
- Bach, T., Shenvi, R. A., Weix, D. J., Giralt, E., Schwarz, H. Honda-Fujishima Lectureship Award for Thorsten Bach Angewandte Chemie-International Edition 2015 54:2003-2003 DOI:10.1002/anie.201412056
- Schnermann, M. J., Shenvi, R. A. Syntheses and biological studies of marine terpenoids derived from inorganic cyanide Natural Product Reports 2015 32:543-577 DOI:10.1039/c4np00109e PMID:25514696 PMCID:PMC4414506
- Crossley, S. W. M., Barabe, F., Shenvi, R. A. Simple, chemoselective, catalytic olefin isomerization Journal of the American Chemical Society 2014 136:16788-16791 DOI:10.1021/ja5105602 PMID:25398144 PMCID:PMC4277770
- Iwasaki, K., Wan, K. K., Oppedisano, A., Crossley, S. W. M., Shenvi, R. A. Simple, chemoselective hydrogenation with thermodynamic stereocontrol Journal of the American Chemical Society 2014 136:1300-1303 DOI:10.1021/ja412342g PMID:24428640 PMCID:PMC3951266
- Jansen, D. J., Shenvi, R. A. Synthesis of medicinally relevant terpenes: reducing the cost and time of drug discovery Future Medicinal Chemistry 2014 6:1127-1146 DOI:10.4155/fmc.14.71 PMID:25078134 PMCID:PMC4162426
- Shenvi, R. A., Pronin, S. V. Synthesis of highly strained terpenes by non-stop tail-to-head polycyclization Synthesis-Stuttgart 2013 45:A19-A20 DOI:10.1055/s-003-24382 PMID:23089866
- Jansen, D. J., Shenvi, R. A. Synthesis of (-)-neothiobinupharidine Journal of the American Chemical Society 2013 135:1209-1212 DOI:10.1021/ja310778t PMID:23298203
- Pronin, S. V., Reiher, C. A., Shenvi, R. A. Stereoinversion of tertiary alcohols to tertiary-alkyl isonitriles and amines Nature 2013 501:195-199 DOI:10.1038/nature12472 PMID:24025839
- Pronin, S. V., Shenvi, R. A. Synthesis of a potent antimalarial amphilectene Journal of the American Chemical Society 2012 134:19604-19606 DOI:10.1021/0310129b PMID:23153381
- Pronin, S. V., Shenvi, R. A. Synthesis of highly strained terpenes by non-stop tail-to-head polycyclization Nature Chemistry 2012 4:915-920 DOI:10.1038/nchem.1458 PMID:23089866
- Pronin, S. V., Tabor, M. G., Jansen, D. J., Shenvi, R. A. A stereoselective hydroamination transform to access polysubstituted indolizidines Journal of the American Chemical Society 2012 134:2012-2015 DOI:10.1021/ja211090n PMID:22263967
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Shi, J., Manolikakes, G., Yeh, C. H., Guerrero, C. A., Shenvi, R. A., Shigehisa, H., Baran, P. S.
Scalable synthesis of cortistatin A and related structures
Journal of the American Chemical Society
2011
133:8014-8027
DOI:10.1021/ja202103e
PMID:21539314
PMCID:PMC3119343
- Shenvi, R. A., Corey, E. J. Synthetic access to bent polycycles by cation-pi cyclization Organic Letters 2010 12:3548-3551 DOI:10.1021/ol101410g PMID:20670018 PMCID:PMC2914341
- Shenvi, R. A., Corey, E. J. A short and efficient synthesis of (-)-7-methylomuralide, a potent proteasome inhibitor Journal of the American Chemical Society 2009 131:5746-5747 DOI:10.1021/ja901400q PMID:19338298 PMCID:PMC2714661
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Shenvi, R. A., O'Malley, D. P., Baran, P. S.
Chemoselectivity: The mother of invention in total synthesis
Accounts of Chemical Research
2009
42:530-541
DOI:10.1021/ar800182r
PMID:19182997
PMCID:PMC2765532
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Shi, J., Shigehisa, H., Guerrero, C. A., Shenvi, R. A., Li, C. C., Baran, P. S.
Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: Application and biological evaluation of D-ring cortistatin analogues
Angewandte Chemie-International Edition
2009
48:4328-4331
DOI:10.1002/anie.200901116
PMID:19434636
PMCID:PMC3495592
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Shenvi, R. A., Guerrero, C. A., Shi, J., Li, C. C., Baran, P. S.
Synthesis of (+)-cortistatin A
Journal of the American Chemical Society
2008
130:7241-7243
DOI:10.1021/ja8023466
PMID:18479104
PMCID:PMC2652360
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Baran, P. S., Shenvi, R. A., Nguyen, S. A.
One-step synthesis of 4,5-disubstituted pyrimidines using commercially available and inexpensive reagents
Heterocycles
2006
70:581-586
DOI:10.3987/COM-06-S(W)27
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Baran, P. S., Shenvi, R. A.
Total synthesis of (+/-)-chartelline C
Journal of the American Chemical Society
2006
128:14028-14029
DOI:10.1021/ja0659673
PMID:17061876
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Baran, P. S., Shenvi, R. A., Mitsos, C. A.
A remarkable ring contraction en route to the chartelline alkaloids
Angewandte Chemie-International Edition
2005
44:3714-3717
DOI:10.1002/anie.200500522
PMID:15900528
- Ababou, A., Shenvi, R. A., Desjarlais, J. R. Long-range effects on calcium binding and conformational change in the n-domain of calmodulin Biochemistry 2001 40:12719-12726 DOI:10.1021/bi010405b PMID:11601997
