recent publications
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academic article
- Iaconelli, J., Ibrahim, L., Chen, E., Hull, M., Schultz, P. G., Bollong, M. J. Small-molecule stimulators of NRF1 transcriptional activity Chembiochem 2020 DOI:10.1002/cbic.201900487 PMID:31596542
- Dik, D. A., Zhang, N., Chen, J. S., Webb, B., Schultz, P. G. Semisynthesis of a Bacterium with Non-canonical Cell-Wall Cross-Links Journal of the American Chemical Society 2020 142:10910-10913 DOI:10.1021/jacs.0c02956 PMID:32510943
- Zambaldo, C., Vinogradova, E. V., Qi, X., Iaconelli, J., Suciu, R. M., Koh, M., Senkane, K., Chadwick, S. R., Sanchez, B. B., Chen, J. S., Chatterjee, A. K., Liu, P., et al. 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles Journal of the American Chemical Society 2020 142:8972-8979 DOI:10.1021/jacs.0c02721 PMID:32302104
- Shao, S., Koh, M., Schultz, P. G. Expanding the genetic code of the human hematopoietic system Proceedings of the National Academy of Sciences of the United States of America 2020 117:8845-8849 DOI:10.1073/pnas.1914408117 PMID:32253306 PMCID:PMC7183198
- Zambaldo, C., Koh, M., Nasertorabi, F., Han, G. W., Chatterjee, A., Stevens, R. C., Schultz, P. G. An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli! Bioorganic & Medicinal Chemistry 2020 28 DOI:10.1016/j.bmc.2020.115662 PMID:33069069
- Chin, E. N., Yu, C. G., Vartabedian, V. F., Jia, Y., Kumar, M., Gamo, A. M., Vernier, W., Ali, S. H., Kissai, M., Lazar, D. C., Nguyen, N., Pereira, L. E., et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic Science 2020 369:993-999 DOI:10.1126/science.abb4255 PMID:32820126
- Riva, L., Yuan, S. F., Yin, X., Martin-Sancho, L., Matsunaga, N., Pache, L., Burgstaller-Muehlbacher, S., De Jesus, P. D., Teriete, P., Hull, M. V., Chang, M. W., Chan, J. F. W., et al. Discovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposing Nature 2020 586:113-119 DOI:10.1038/s41586-020-2577-1 PMID:32707573
- Lear, S., Pflimlin, E., Zhou, Z. H., Huang, D., Weng, S., Nguyen-Tran, V., Joseph, S. B., Roller, S., Peterson, S., Li, J., Tremblay, M., Schultz, P. G., et al. Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity Journal of Medicinal Chemistry 2020 63:9660-9671 DOI:10.1021/acs.jmedchem.0c00740 PMID:32844654
- Ardestani, A., Li, S., Annamalai, K., Lupse, B., Gerayandi, S., Dobrowolski, A., Yu, S., Zhu, S., Baguley, T. D., Surakattula, M., Oetjen, J., Hauberg-Lotte, L., et al. Neratinib protects pancreatic beta cells in diabetes Nature Communications 2019 10 DOI:10.1038/s41467-019-12880-5 PMID:31676778 PMCID:PMC6825211
- Mehta, A. P., Ko, Y., Supekova, L., Pestonjamasp, K., Li, J., Schultz, P. G. Toward a synthetic yeast endosymbiont with a minimal genome Journal of the American Chemical Society 2019 141:13799-13802 DOI:10.1021/jacs.9b08290 PMID:31419116
- Zhang, Y., Fang, C., Wang, R. S. E., Wang, Y., Guo, H., Guo, C., Zhao, L., Li, S., Li, X., Schultz, P. G., Cao, Y. J., Wang, F. A tumor-targeted immune checkpoint blocker Proceedings of the National Academy of Sciences of the United States of America 2019 116:15889-15894 DOI:10.1073/pnas.1905646116 PMID:31332018 PMCID:PMC6689898
- Koh, M., Cho, H. Y., Yu, C., Choi, S., Lee, K. B., Schultz, P. G. Site-specific incorporation of a dithiolane containing amino acid into proteins Bioconjugate Chemistry 2019 .30:2102-2105 DOI:10.1021/acs.bioconjchem.9b00413 PMID:31319026
- Li, J. C., Nastertorabi, F., Xuan, W., Han, G. W., Stevens, R. C., Schultz, P. G. A single reactive noncanonical amino acid is able to dramatically stabilize protein structure ACS Chemical Biology 2019 14:1150-1153 DOI:10.1021/acschembio.9b00002 PMID:31181898
- Bakowski, M. A., Shiroodi, R. K., Liu, R., Olejniczak, J., Yang, B., Gagaring, K., Guo, H., White, P. M., Chappell, L., Debec, A., Landmann, F., Dubben, B., et al. Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections Science Translational Medicine 2019 11 DOI:10.1126/scitranslmed.aav3523 PMID:31068442
- Lucki, N. C., Villa, G. R., Vergani, N., Bollong, M. J., Beyer, B. A., Lee, J. W., Anglin, J. L., Spangenberg, S. H., Chin, E. N., Sharma, A., Johnson, K., Sander, P. N., et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer Proceedings of the National Academy of Sciences of the United States of America 2019 116:6435-6440 DOI:10.1073/pnas.1816626116 PMID:30846550 PMCID:PMC6442583
- Ahmed, N., De Graaf, J. F., Ahmed, N., Foss, D. V., Delcorde, J., Schultz, P. G., Pezacki, J. P. Visualization of the delivery and release of small RNAs using genetic code expansion and unnatural RNA-binding proteins Bioconjugate Chemistry 2018 29:3982-3986 DOI:10.1021/acs.bioconjchem.8b00649 PMID:30408949
- Li, J. C., Liu, T., Wang, Y., Mehta, A. P., Schultz, P. G. Enhancing protein stability with genetically encoded noncanonical amino acids Journal of the American Chemical Society 2018 140:15997-16000 DOI:10.1021/jacs.8b07157 PMID:30433771
- Mehta, A. P., Supekova, L., Chen, J. H., Pestonjamasp, K., Webster, P., Ko, Y., Henderson, S. C., McDermott, G., Supek, F., Schultz, P. G. Engineering yeast endosymbionts as a step toward the evolution of mitochondria Proceedings of the National Academy of Sciences of the United States of America 2018 115:11796-11801 DOI:10.1073/pnas.1813143115 PMID:30373839 PMCID:PMC6243291
- Bollong, M. J., Lee, G., Coukos, J. S., Yun, H., Zambaldo, C., Chang, J. W., Chin, E. N., Ahmad, I., Chatterjee, A. K., Lairson, L. L., Schultz, P. G., Moellering, R. E. A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling Nature 2018 562:600-604 DOI:10.1038/s41586-018-0622-0 PMID:30323285
- Janes, J., Young, M. E., Chen, E., Rogers, N. H., Burgstaller-Muehlbacher, S., Hughes, L. D., Love, M. S., Hull, M. V., Kuhen, K. L., Woods, A. K., Joseph, S. B., Petrassi, H. M., et al. The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis Proceedings of the National Academy of Sciences of the United States of America 2018 115:10750-10755 DOI:10.1073/pnas.1810137115 PMID:30282735 PMCID:PMC6196526
- Yao, A., Reed, S. A., Koh, M., Yu, C., Luo, X., Mehta, A. P., Schultz, P. G. Progress toward a reduced phage genetic code Bioorganic & Medicinal Chemistry 2018 26:5247-5252 DOI:10.1016/j.bmc.2018.03.035 PMID:29609949
- Mehta, A. P., Wang, Y., Reed, S. A., Supekova, L., Javahishvili, T., Chaput, J. C., Schultz, P. G. Bacterial genome containing chimeric DNA-RNA sequences Journal of the American Chemical Society 2018 140:11464-11473 DOI:10.1021/jacs.8b07046 PMID:30160955
- Zhong, L., Tran, T., Baguley, T. D., Lee, S. J., Henke, A., To, A., Li, S., Yu, S., Grieco, F. A., Roland, J., Schultz, P. G., Eizirik, D. L., et al. A novel inhibitor of inducible NOS dimerization protects against cytokine-induced rat beta cell dysfunction British Journal of Pharmacology 2018 175:3470-3485 DOI:10.1111/bph.14388 PMID:29888783 PMCID:PMC6086989
- Crnovcic, I., Gan, F., Yang, D., Dong, L. B., Schultz, P. G., Shen, B. Activities of recombinant human bleomycin hydrolase on bleomycins and engineered analogues revealing new opportunities to overcome bleomycin-induced pulmonary toxicity Bioorganic & Medicinal Chemistry Letters 2018 28:2670-2674 DOI:10.1016/j.bmcl.2018.04.065 PMID:29730026
- Abdeen, S., Kunkle, T., Salim, N., Ray, A. M., Mammadova, N., Summers, C., Stevens, M., Ambrose, A. J., Park, Y., Schultz, P. G., Horwich, A. L., Hoang, Q. Q., et al. Sulfonamido-2-arylbenzoxazole GroEL/ES inhibitors as potent antibacterials against methicillin-resistant Staphylococcus aureus (MRSA) Journal of Medicinal Chemistry 2018 61:7345-7357 DOI:10.1021/acs.jmedchem.8b00989 PMID:30060666
- Zhang, G., Baidin, V., Pahil, K. S., Moison, E., Tomasek, D., Ramadoss, N. S., Chatterjee, A. K., McNamara, C. W., Young, T. S., Schultz, P. G., Meredith, T. C., Kahne, D. Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors Proceedings of the National Academy of Sciences of the United States of America 2018 115:6834-6839 DOI:10.1073/pnas.1804670115 PMID:29735709 PMCID:PMC6042065
- Wang, J., Schultz, P. G., Johnson, K. A. Mechanistic studies of a small-molecule modulator of SMN2 splicing Proceedings of the National Academy of Sciences of the United States of America 2018 115:E4604-E4612 DOI:10.1073/pnas.1800260115 PMID:29712837 PMCID:PMC5960314
- Supekova, L., Zambaldo, C., Cho, S., Lim, R., Luo, X., Kazane, S. A., Young, T. S., Schultz, P. G. The genetic incorporation of p-azidomethyl-L-phenylalanine into proteins in yeast Bioorganic & Medicinal Chemistry Letters 2018 28:1570-1573 DOI:10.1016/j.bmcl.2018.03.055 PMID:29625824
- Yang, P. Y., Zou, H., Lee, C., Muppidi, A., Chao, E., Fu, Q., Luo, X., Wang, D., Schultz, P. G., Shen, W. Stapled, long-acting glucagon-like peptide 2 analog with efficacy in dextran sodium sulfate induced mouse colitis models Journal of Medicinal Chemistry 2018 61:3218-3223 DOI:10.1021/acs.jmedchem.7b00768 PMID:29528634
- Young, D. D., Schultz, P. G. Playing with the molecules of life ACS Chemical Biology 2018 13:854-870 DOI:10.1021/acschembio.7b00974 PMID:29345901
- Gan, F., Liu, R., Wang, F., Schultz, P. G. Functional replacement of histidine in proteins to generate noncanonical amino acid dependent organisms Journal of the American Chemical Society 2018 140:3829-3832 DOI:10.1021/jacs.7b13452 PMID:29509426
- Xuan, W., Collins, D., Koh, M., Shao, S., Yao, A., Xiao, H., Garner, P., Schultz, P. G. Site-specific incorporation of a thioester containing amino acid into proteins ACS Chemical Biology 2018 13:578-581 DOI:10.1021/acschembio.7b00998 PMID:29360343 PMCID:PMC5856652
- Du, J., Cao, Y., Liu, Y., Wang, Y., Zhang, Y., Fu, G., Zhang, Y., Lu, L., Luo, X., Kim, C. H., Schultz, P. G., Wang, F. Engineering bifunctional antibodies with constant region fusion architectures Journal of the American Chemical Society 2017 139:18607-18615 DOI:10.1021/jacs.7b09641 PMID:29186655
- Bollong, M. J., Pietila, M., Pearson, A. D., Sarkar, T. R., Ahmad, I., Soundararajan, R., Lyssiotis, C. A., Mani, S. A., Schultz, P. G., Lairson, L. L. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers Proceedings of the National Academy of Sciences of the United States of America 2017 114:E9903-E9912 DOI:10.1073/pnas.1716009114 PMID:29087350 PMCID:PMC5699095
- Laborda, E., Mazagova, M., Shao, S., Wang, X., Quirino, H., Woods, A. K., Hampton, E. N., Rodgers, D. T., Kim, C. H., Schultz, P. G., Young, T. S. Development of A chimeric antigen receptor targeting C-type lectin-like molecule-1 for human acute myeloid leukemia International Journal of Molecular Sciences 2017 18 DOI:10.3390/ijms18112259 PMID:29077054 PMCID:PMC5713229
- Choi, S. H., Mahankali, M., Lee, S. J., Hull, M., Petrassi, H. M., Chatterjee, A. K., Schultz, P. G., Jones, K. A., Shen, W. Targeted disruption of Myc-Max oncoprotein complex by a small molecule ACS Chemical Biology 2017 12:2715-2719 DOI:10.1021/acschembio.7b00799 PMID:28976731
- Xuan, W., Yao, A., Schultz, P. G. Genetically encoded fluorescent probe for detecting sirtuins in living cells Journal of the American Chemical Society 2017 139:12350-12353 DOI:10.1021/jacs.7b05725 PMID:28857557
- Zambaldo, C., Luo, X., Mehta, A. P., Schultz, P. G. Recombinant macrocyclic lanthipeptides incorporating non-canonical amino acids Journal of the American Chemical Society 2017 139:11646-11649 DOI:10.1021/jacs.7b04159 PMID:28809560
- Luo, X., Fu, G., Wang, R. S. E., Zhu, X., Zambaldo, C., Liu, R., Liu, T., Lyu, X., Du, J., Xuan, W., Yao, A., Reed, S. A., et al. Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria Nature Chemical Biology 2017 13:845-849 DOI:10.1038/nchembio.2405 PMID:28604693
- Xuan, W. M., Schultz, P. G. A strategy for creating organisms dependent on noncanonical amino acids Angewandte Chemie-International Edition 2017 56:9170-9173 DOI:10.1002/anie.201703553 PMID:28593724 PMCID:PMC5580492
- Lee, S. J., Mahankali, M., Bitar, A., Zou, H., Chao, E., Nguyen, H., Gonzalez, J., Caballero, D., Hull, M., Wang, D., Schultz, P. G., Shen, W. A novel role for RARα agonists as apolipoprotein CIII inhibitors identified from high throughput screening Scientific Reports 2017 7 DOI:10.1038/s41598-017-05163-w
- Liu, T., Jia, P., Ma, H., Reed, S. A., Luo, X., Larman, H. B., Schultz, P. G. Construction and screening of a lentiviral secretome library Cell Chemical Biology 2017 24:767-771 DOI:10.1016/j.chembiol.2017.05.017 PMID:28602759
- Bollong, M. J., Yang, B., Vergani, N., Beyer, B. A., Chin, E. N., Zambaldo, C., Wang, D., Chatterjee, A. K., Lairson, L. L., Schultz, P. G. Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis Proceedings of the National Academy of Sciences of the United States of America 2017 114:4679-4684 DOI:10.1073/pnas.1702750114 PMID:28416697 PMCID:PMC5422806
- Koh, M., Nasertorabi, F., Han, G. W., Stevens, R. C., Schultz, P. G. Generation of an orthogonal protein-protein interface with a noncanonical amino acid Journal of the American Chemical Society 2017 139:5728-5731 DOI:10.1021/jacs.7b02273 PMID:28413876
- Xuan, W., Shao, S., Schultz, P. G. Protein crosslinking by genetically encoded noncanonical amino acids with reactive aryl carbamate side chains Angewandte Chemie-International Edition 2017 56:5096-5100 DOI:10.1002/anie.201611841 PMID:28371162
- Love, M. S., Beasley, F. C., Jumani, R. S., Wright, T. M., Chatterjee, A. K., Huston, C. D., Schultz, P. G., McNamara, C. W. A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis PLoS Neglected Tropical Diseases 2017 11 DOI:10.1371/journal.pntd.0005373 PMID:28158186 PMCID:PMC5310922
- Yu, S., Pearson, A. D., Lim, R. K. V., Rodgers, D. T., Li, S., Parker, H. B., Weglarz, M., Hampton, E. N., Bollong, M. J., Shen, J., Zambaldo, C., Wang, D., et al. Targeted delivery of an anti-inflammatory PDE4 inhibitor to immune cells via an antibody-drug conjugate Molecular Therapy 2016 24:2078-2089 DOI:10.1038/mt.2016.175 PMID:27731313 PMCID:PMC5167782
- Mehta, A. P., Li, H., Reed, S. A., Supekova, L., Javahishvili, T., Schultz, P. G. Replacement of 2 '-deoxycytidine by 2 '-deoxycytidine analogues in the E. coli genome Journal of the American Chemical Society 2016 138:14230-14233 DOI:10.1021/jacs.6b09661 PMID:27762133 PMCID:PMC5134732
- Liu, Y., Wang, Y., Zhang, Y., Liu, T., Jia, H., Zou, H., Fu, Q., Zhang, Y., Lu, L., Chao, E., Parker, H., Nguyen-Tran, V., et al. Rational design of dual agonist-antibody fusions as long-acting therapeutic hormones ACS Chemical Biology 2016 11:2991-2995 DOI:10.1021/acschembio.6b00630 PMID:27704775 PMCID:PMC5148668
- Abdeen, S., Salim, N., Mammadova, N., Summers, C. M., Goldsmith-Pestana, K., McMahon-Pratt, D., Schultz, P. G., Horwich, A. L., Chapman, E., Johnson, S. M. Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness Bioorganic & Medicinal Chemistry Letters 2016 26:5247-5253 DOI:10.1016/j.bmcl.2016.09.051 PMID:27720295
- Wang, R. S. E., Wang, Y., Zhang, Y., Gabrelow, C., Zhang, Y., Chi, V., Fu, Q., Luo, X., Wang, D., Joseph, S., Johnson, K., Chatterjee, A. K., et al. Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant Proceedings of the National Academy of Sciences of the United States of America 2016 113:11501-11506 DOI:10.1073/pnas.1612803113 PMID:27663736 PMCID:PMC5068325
- Luo, X., Wang, T. S. A., Zhang, Y., Wang, F., Schultz, P. G. Stabilizing protein motifs with a genetically encoded metal-ion chelator Cell Chemical Biology 2016 23:1098-1102 DOI:10.1016/j.chembiol.2016.08.007 PMID:27662253
- Zhang, Z., English, B. P., Grimm, J. B., Kazane, S. A., Hu, W., Tsai, A., Inouye, C., You, C., Piehler, J., Schultz, P. G., Lavis, L. D., Revyakin, A., et al. Rapid dynamics of general transcription factor TFIIB binding during preinitiation complex assembly revealed by single-molecule analysis Genes & Development 2016 30:2106-2118 DOI:10.1101/gad.285395.116 PMID:27798851 PMCID:PMC5066616
- Xiao, H., Schultz, P. G. At the interface of chemical and biological synthesis: an expanded genetic code Cold Spring Harbor Perspectives in Biology 2016 8 DOI:10.1101/cshperspect.a023945 PMID:27413101
- Xuan, W., Li, J., Luo, X., Schultz, P. G. Genetic incorporation of a reactive isothiocyanate group into proteins Angewandte Chemie-International Edition 2016 55:10065-10068 DOI:10.1002/anie.201604891 PMID:27418387
- Abdeen, S., Salim, N., Mammadova, N., Summers, C. M., Frankson, R., Ambrose, A. J., Anderson, G. G., Schultz, P. G., Horwich, A. L., Chapman, E., Johnson, S. M. GroEL/ES inhibitors as potential antibiotics Bioorganic & Medicinal Chemistry Letters 2016 26:3127-3134 DOI:10.1016/j.bmcl.2016.04.089 PMID:27184767
- Cao, Y., Rodgers, D. T., Du, J., Ahmad, I., Hampton, E. N., Ma, J. S. Y., Mazagova, M., Choi, S. H., Yun, H. Y., Xiao, H., Yang, P., Luo, X., et al. Design of switchable chimeric antigen receptor T cells targeting breast cancer Angewandte Chemie-International Edition 2016 55:7520-7524 DOI:10.1002/anie.201601902 PMID:27145250
- Mehta, A. P., Li, H., Reed, S. A., Supekova, L., Javahishvili, T., Schultz, P. G. Replacement of Thymidine by a Modified Base in the Escherichia coli Genome Journal of the American Chemical Society 2016 138:7272-7275 DOI:10.1021/jacs.6b03904 PMID:27213685
- Lee, T. C., Kim, C. H., Schultz, P. G., Chapman, E., Deniz, A. A., Kang, M. Dual unnatural amino acid incorporation and click-chemistry labeling to enable single-molecule FRET studies of p97 folding ChemBioChem 2016 17:981-984 DOI:10.1002/cbic.201500695 PMID:27115850 PMCID:PMC4904727
- Liu, T., Wang, Y., Luo, X., Li, J., Reed, S. A., Xiao, H., Young, T. S., Schultz, P. G. Enhancing protein stability with extended disulfide bonds Proceedings of the National Academy of Sciences of the United States of America 2016 113:5910-5915 DOI:10.1073/pnas.1605363113 PMID:27162342 PMCID:PMC4889405
- Yang, P. Y., Zou, H., Chao, E., Sherwood, L., Nunez, V., Keeney, M., Ghartey-Tagoe, E., Ding, Z., Quirino, H., Luo, X., Welzel, G., Chen, G., et al. Engineering a long-acting, potent GLP-1 analog for microstructure-based transdermal delivery Proceedings of the National Academy of Sciences of the United States of America 2016 113:4140-4145 DOI:10.1073/pnas.1601653113 PMID:27035989 PMCID:PMC4839405
- Luo, X., Zambaldo, C., Liu, T., Zhang, Y., Xuan, W., Wang, C., Reed, S. A., Yang, P. Y., Wang, R. E., Javahishvili, T., Schultz, P. G., Young, T. S. Recombinant thiopeptides containing noncanonical amino acids Proceedings of the National Academy of Sciences of the United States of America 2016 113:3615-3620 DOI:10.1073/pnas.1602733113 PMID:26976568 PMCID:PMC4822594
- Muppidi, A., Zou, H., Yang, P. Y., Chao, E., Sherwood, L., Nunez, V., Woods, A. K., Schultz, P. G., Lin, Q., Shen, W. Design of potent and proteolytically stable oxyntomodulin analogs ACS Chemical Biology 2016 11:324-328 DOI:10.1021/acschembio.5b00787 PMID:26727558 PMCID:PMC4861236
- Rodgers, D. T., Mazagova, M., Hampton, E. N., Cao, Y., Ramadoss, N. S., Hardy, I. R., Schulman, A., Du, J., Wang, F., Singer, O., Ma, J., Nunez, V., et al. Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies Proceedings of the National Academy of Sciences of the United States of America 2016 113:E459-E468 DOI:10.1073/pnas.1524155113 PMID:26759369 PMCID:PMC4743815
- Ma, J. S. Y., Kim, J. Y., Kazane, S. A., Choi, S. H., Yun, H. Y., Kim, M. S., Rodgers, D. T., Pugh, H. M., Singer, O., Sun, S. B., Fonslow, B. R., Kochenderfer, J. N., et al. Versatile strategy for controlling the specificity and activity of engineered T cells Proceedings of the National Academy of Sciences of the United States of America 2016 113:E450-E458 DOI:10.1073/pnas.1524193113 PMID:26759368 PMCID:PMC4743826
- Luo, X., Liu, T., Wang, Y., Jia, H., Zhang, Y., Caballero, D., Du, J., Wang, R. E., Wang, D., Schultz, P. G., Wang, F. An epitope-specific respiratory syncytial virus vaccine based on an antibody scaffold Angewandte Chemie-International Edition 2015 54:14531 DOI:10.1002/anie.201507928 PMID:26434555 PMCID:PMC4715490
- Lim, R. K. V., Yu, S., Cheng, B., Li, S., Kim, N. J., Cao, Y., Chi, V., Kim, J. Y., Chatterjee, A. K., Schultz, P. G., Tremblay, M. S., Kazane, S. A. Targeted delivery of LXR Agonist Using a site-specific antibody drug conjugate Bioconjugate Chemistry 2015 26:2216-2222 DOI:10.1021/acs.bioconjchem.5b00203 PMID:25945727 PMCID:PMC4651790
- Bollong, M. J., Yun, H., Sherwood, L., Woods, A. K., Lairson, L. L., Schultz, P. G. A small molecule inhibits deregulated NRF2 transcriptional activity in cancer ACS Chemical Biology 2015 10:2193-2198 DOI:10.1021/acschembio.5b00448 PMID:26270491
- Liu, T., Du, J., Luo, X., Schultz, P. G., Wang, F. Homogeneously modified immunoglobulin domains for therapeutic application Current Opinion in Chemical Biology 2015 28:66-74 DOI:10.1016/j.cbpa.2015.06.007 PMID:26117722
- Xiao, H., Xuan, W., Shao, S., Liu, T., Schultz, P. G. Genetic incorporation of ε-N-2-hydroxyisobutyryl-lysine into recombinant histones ACS Chemical Biology 2015 10:1599-1603 DOI:10.1021/cb501055h PMID:25909834 PMCID:PMC4506705
- Cao, Y., Axup, J. Y., Ma, J. S. Y., Wang, R. E., Choi, S., Tardif, V., Lim, R. K. V., Pugh, H. M., Lawson, B. R., Welzel, G., Kazane, S. A., Sun, Y., et al. Multiformat T-cell-engaging bispecific antibodies targeting human breast cancers Angewandte Chemie-International Edition 2015 54:7022-7027 DOI:10.1002/anie.201500799 PMID:25919418 PMCID:PMC4492699
- Xiao, H., Nasertorabi, F., Choi, S. H., Han, G. W., Reed, S. A., Stevens, R. C., Schultz, P. G. Exploring the potential impact of an expanded genetic code on protein function Proceedings of the National Academy of Sciences of the United States of America 2015 112:6961-6966 DOI:10.1073/pnas.1507741112 PMID:26038548 PMCID:PMC4460475
- Harbut, M. B., Vilcheze, C., Luo, X., Hensler, M. E., Guo, H., Yang, B., Chatterjee, A. K., Nizet, V., Jacobs Jr., W. R., Schultz, P. G., Wang, F. Auranofin exerts broad-spectrum bactericidal activities by targeting thiol-redox homeostasis Proceedings of the National Academy of Sciences of the United States of America 2015 112:4453-4458 DOI:10.1073/pnas.1504022112 PMID:25831516 PMCID:PMC4394260
- Liu, T., Fu, G., Luo, X., Liu, Y., Wang, Y., Wang, R. E., Schultz, P. G., Wang, F. Rational design of antibody protease inhibitors Journal of the American Chemical Society 2015 137:4042-4045 DOI:10.1021/ja5130786 PMID:25775396
- Kim, M. S., Ma, J. S. Y., Yun, H., Cao, Y., Kim, J. Y., Chi, V., Wang, D., Woods, A., Sherwood, L., Caballero, D., Gonzalez, J., Schultz, P. G., et al. Redirection of genetically engineered CAR-T cells using bifunctional small molecules Journal of the American Chemical Society 2015 137:2832-2835 DOI:10.1021/jacs.5b00106 PMID:25692571
- Pearson, A. D., Mills, J. H., Song, Y., Nasertorabi, F., Han, G. W., Baker, D., Stevens, R. C., Schultz, P. G. Trapping a transition state in a computationally designed protein bottle Science 2015 347:863-867 DOI:10.1126/science.aaa2424 PMID:25700516 PMCID:PMC4581533
- Liu, T., Zhang, Y., Liu, Y., Wang, Y., Jia, H., Kang, M., Luo, X., Caballero, D., Gonzalez, J., Sherwood, L., Nunez, V., Wang, D., et al. Functional human antibody CDR fusions as long-acting therapeutic endocrine agonists Proceedings of the National Academy of Sciences of the United States of America 2015 112:1356-1361 DOI:10.1073/pnas.1423668112 PMID:25605877 PMCID:PMC4321239
- Wang, R. E., Liu, T., Wang, Y., Cao, Y., Du, J., Luo, X., Deshmukh, V., Kim, C. H., Lawson, B. R., Tremblay, M. S., Young, T. S., Kazane, S. A., et al. An immunosuppressive antibody-drug conjugate Journal of the American Chemical Society 2015 137:3229-3232 DOI:10.1021/jacs.5b00620 PMID:25699419 PMCID:PMC4472444
- Decker, R. S., Koyama, E., Enomoto-Iwamoto, M., Maye, P., Rowe, D., Zhu, S., Schultz, P. G., Pacifici, M. Mouse limb skeletal growth and synovial joint development are coordinately enhanced by Kartogenin Developmental Biology 2014 395:255-267 DOI:10.1016/j.ydbio.2014.09.011 PMID:25238962 PMCID:PMC4253021
- Kularatne, S. A., Deshmukh, V., Ma, J., Tardif, V., Lim, R. K. V., Pugh, H. M., Sun, Y., Manibusan, A., Sellers, A. J., Barnett, R. S., Srinagesh, S., Forsyth, J. S., et al. A CXCR4-targeted site-specific antibody-drug conjugate Angewandte Chemie-International Edition 2014 53:11863-11867 DOI:10.1002/anie.201408103 PMID:25213874 PMCID:PMC4331128
- Lu, H., Zhou, Q., Deshmukh, V., Phull, H., Ma, J., Tardif, V., Naik, R. R., Bouvard, C., Zhang, Y., Choi, S., Lawson, B. R., Zhu, S., et al. Targeting human C-type lectin-like molecule-1 (CLL1) with a bispecific antibody for immunotherapy of acute myeloid leukemia Angewandte Chemie-International Edition 2014 53:9841-9845 DOI:10.1002/anie.201405353 PMID:25056598 PMCID:PMC4280064
- Chatterjee, A., Lajoie, M. J., Xiao, H., Church, G. M., Schultz, P. G. A bacterial strain with a unique quadruplet codon specifying non-native amino acids ChemBioChem 2014 15:1782-1786 DOI:10.1002/cbic.201402104 PMID:24867343
- Sun, S. B., Schultz, P. G., Kim, C. H. Therapeutic applications of an expanded genetic code ChemBioChem 2014 15:1721-1729 DOI:10.1002/cbic.201402154 PMID:25044800 PMCID:PMC4472442
- Liu, T., Liu, Y., Wang, Y., Hull, M., Schultz, P. G., Wang, F. Rational design of CXCR4 specific antibodies with elongated CDRs Journal of the American Chemical Society 2014 136:10557-10560 DOI:10.1021/ja5042447 PMID:25041362 PMCID:PMC4120998
- Furman, J. L., Kang, M. C., Choi, S., Cao, Y., Wold, E. D., Sun, S. B., Smider, V. V., Schultz, P. G., Kim, C. H. A genetically encoded aza-Michael acceptor for covalent cross-linking of protein-receptor complexes Journal of the American Chemical Society 2014 136:8411-8417 DOI:10.1021/ja502851h PMID:24846839 PMCID:PMC4227728
- Xiao, H., Peters, F. B., Yang, P. Y., Reed, S., Chittuluru, J. R., Schultz, P. G. Genetic incorporation of histidine derivatives using an engineered pyrrolysyl-tRNA synthetase ACS Chemical Biology 2014 9:1092-1096 DOI:10.1021/cb500032c PMID:24506189 PMCID:PMC4033645
- Kang, M., Light, K., Ai, H. W., Shen, W., Kim, C. H., Chen, P. R., Lee, H. S., Solomon, E. I., Schultz, P. G. Evolution of iron(II)-finger peptides by using a bipyridyl amino acid ChemBioChem 2014 15:822-825 DOI:10.1002/cbic.201300727 PMID:24591102 PMCID:PMC4010245
- Javahishvili, T., Manibusan, A., Srinagesh, S., Lee, D., Ensari, S., Shimazu, M., Schultz, P. G. Role of tRNA orthogonality in an expanded genetic code ACS Chemical Biology 2014 9:874-879 DOI:10.1021/cb4005172 PMID:24443971 PMCID:PMC4167058
- Kessel, C., Nandakumar, K. S., Peters, F. B., Gauba, V., Schultz, P. G., Holmdahl, R. A single functional group substitution in c5a breaks B cell and T cell tolerance and protects against experimental arthritis Arthritis & Rheumatology 2014 66:610-621 DOI:10.1002/art.38237 PMID:24574221 PMCID:PMC4302760
- Rust, H. L., Subramanian, V., West, G. M., Young, D. D., Schultz, P. G., Thompson, P. R. Using unnatural amino acid mutagenesis to probe the regulation of PRMT1 ACS Chemical Biology 2014 9:649-655 DOI:10.1021/cb400859z PMID:24358983 PMCID:PMC4505744
- Tian, F., Lu, Y., Manibusan, A., Sellers, A., Tran, H., Sun, Y., Phuong, T., Barnett, R., Hehli, B., Song, F., DeGuzman, M. J., Ensari, S., et al. A general approach to site-specific antibody drug conjugates Proceedings of the National Academy of Sciences of the United States of America 2014 111:1766-1771 DOI:10.1073/pnas.1321237111 PMID:24443552 PMCID:PMC3918752
- Johnson, S. M., Sharif, O., Mak, P. A., Wang, H. T., Engels, I. H., Brinker, A., Schultz, P. G., Horwich, A. L., Chapman, E. A biochemical screen for GroEL/GroES inhibitors Bioorganic & Medicinal Chemistry Letters 2014 24:786-789 DOI:10.1016/j.bmcl.2013.12.100 PMID:24418775
- Zhang, Y., Goswami, D., Wang, D., Wang, T. S. A., Sen, S., Magliery, T. J., Griffin, P. R., Wang, F., Schultz, P. G. An antibody with a variable-region coiled-coil "knob" domain Angewandte Chemie-International Edition 2014 53:132-135 DOI:10.1002/anie.201307939 PMID:24254636 PMCID:PMC3926434
- Larman, H. B., Scott, E. R., Wogan, M., Oliveira, G., Torkamani, A., Schultz, P. G. Sensitive, multiplex and direct quantification of RNA sequences using a modified RASL assay Nucleic Acids Research 2014 42:9146-9157 DOI:10.1093/nar/gku636 PMID:25063296 PMCID:PMC4132746
- Xiao, H., Chatterjee, A., Choi, S. H., Bajjuri, K. M., Sinha, S. C., Schultz, P. G. Genetic incorporation of multiple unnatural amino acids into proteins in mammalian cells Angewandte Chemie-International Edition 2013 52:14080-14083 DOI:10.1002/anie.201308137 PMID:24353230
- Kularatne, S. A., Deshmukh, V., Gymnopoulos, M., Biroc, S. L., Xia, J. M., Srinagesh, S., Sun, Y., Zou, N., Shimazu, M., Pinkstaff, J., Ensari, S., Knudsen, N., et al. Recruiting cytotoxic T cells to folate-receptor-positive cancer cells Angewandte Chemie-International Edition 2013 52:12101-12104 DOI:10.1002/anie.201306866 PMID:24573789 PMCID:PMC4012751
- Kim, C. H., Axup, J. Y., Lawson, B. R., Yun, H., Tardif, V., Choi, S. H., Zhou, Q., Dubrovska, A., Biroc, S. L., Marsden, R., Pinstaff, J., Smider, V. V., et al. Bispecific small molecule-antibody conjugate targeting prostate cancer Proceedings of the National Academy of Sciences of the United States of America 2013 110:17796-17801 DOI:10.1073/pnas.1316026110 PMID:24127589 PMCID:PMC3816437
- Lajoie, M. J., Rovner, A. J., Goodman, D. B., Aerni, H. R., Haimovich, A. D., Kuznetsov, G., Mercer, J. A., Wang, H. H., Carr, P. A., Mosberg, J. A., Rohland, N., Schultz, P. G., et al. Genomically recoded organisms expand biological functions Science 2013 342:357-360 DOI:10.1126/science.1241459 PMID:24136966 PMCID:PMC4924538
- Deshmukh, V. A., Tardif, V., Lyssiotis, C. A., Green, C. C., Kerman, B., Kim, H. J., Padmanabhan, K., Swoboda, J. G., Ahmad, I., Kondo, T., Gage, F. H., Theofilopoulos, A. N., et al. A regenerative approach to the treatment of multiple sclerosis Nature 2013 502:327-332 DOI:10.1038/nature12647 PMID:24107995 PMCID:PMC4431622
- Zhang, Y., Wang, D. L., Welzel, G., Wang, Y., Schultz, P. G., Wang, F. An antibody CDR3-erythropoietin fusion protein ACS Chemical Biology 2013 8:2117-2121 DOI:10.1021/cb4004749 PMID:23941200 PMCID:PMC3800483
- Lu, H., Wang, D., Kazane, S., Javahishvili, T., Tian, F., Song, F., Sellers, A., Barnett, B., Schultz, P. G. Site-specific antibody-polymer conjugates for siRNA delivery Journal of the American Chemical Society 2013 135:13885-13891 DOI:10.1021/ja4059525 PMID:23924037 PMCID:PMC3955097
- Chatterjee, A., Guo, J. T., Lee, H. S., Schultz, P. G. A genetically encoded fluorescent probe in mammalian cells Journal of the American Chemical Society 2013 135:12540-12543 DOI:10.1021/ja4059553 PMID:23924161 PMCID:PMC3783214
- Zhang, Y., Wang, D. L., de Lichtervelde, L., Sun, S. B., Smider, V. V., Schultz, P. G., Wang, F. Functional antibody CDR3 fusion proteins with enhanced pharmacological properties Angewandte Chemie-International Edition 2013 52:8295-8298 DOI:10.1002/anie.201303656 PMID:23794517 PMCID:PMC3783209
- Chatterjee, A., Xiao, H., Bollong, M., Ai, H. W., Schultz, P. G. Efficient viral delivery system for unnatural amino acid mutagenesis in mammalian cells Proceedings of the National Academy of Sciences of the United States of America 2013 110:11803-11808 DOI:10.1073/pnas.1309584110 PMID:23818609 PMCID:PMC3718144
- Sun, S. B., Sen, S., Kim, N. J., Magliery, T. J., Schultz, P. G., Wang, F. Mutational analysis of 48G7 reveals that somatic hypermutation affects both antibody stability and binding affinity Journal of the American Chemical Society 2013 135:9980-9983 DOI:10.1021/ja402927u PMID:23795814 PMCID:PMC3773045
- Niu, W., Schultz, P. G., Guo, J. T. An expanded genetic code in mammalian cells with a functional quadruplet codon ACS Chemical Biology 2013 8:1640-1645 DOI:10.1021/cb4001662 PMID:23662731 PMCID:PMC4501474
- Swoboda, J. G., Elliott, J., Deshmukh, V., de Lichtervelde, L., Shen, W. J., Tremblay, M. S., Peters, E. C., Cho, C. Y., Lu, B., Girman, S., Wang, S. M., Schultz, P. G. Small molecule mediated proliferation of primary retinal pigment epithelial cells ACS Chemical Biology 2013 8:1407-1411 DOI:10.1021/cb4001712 PMID:23621521 PMCID:PMC3872493
- Wang, F., Ekiert, D. C., Ahmad, I., Yu, W., Zhang, Y., Bazirgan, O., Torkamani, A., Raudsepp, T., Mwangi, W., Criscitiello, M. F., Wilson, I. A., Schultz, P. G., et al. Reshaping antibody diversity Cell 2013 153:1379-1393 DOI:10.1016/j.cell.2013.04.049 PMID:23746848 PMCID:PMC4007204
- Kim, C. H., Axup, J. Y., Schultz, P. G. Protein conjugation with genetically encoded unnatural amino acids Current Opinion in Chemical Biology 2013 17:412-419 DOI:10.1016/j.cbpa.2013.04.017 PMID:23664497 PMCID:PMC4284959
- de Lichtervelde, L., Boitano, A. E., Wang, Y., Krastel, P., Petersen, F., Cooke, M. P., Schultz, P. G. Eupalinilide E inhibits erythropoiesis and promotes the expansion of hematopoietic progenitor cells ACS Chemical Biology 2013 8:866-870 DOI:10.1021/cb4000234 PMID:23441826
- Day, J. W., Kim, C. H., Smider, V. V., Schultz, P. G. Identification of metal ion binding peptides containing unnatural amino acids by phage display Bioorganic & Medicinal Chemistry Letters 2013 DOI:10.1016/j.bmcl.2013.02.106 PMID:23541674
- Chatterjee, A., Sun, S. B., Furman, J. L., Xiao, H., Schultz, P. G. A versatile platform for single- and multiple-unnatural amino acid mutagenesis in Escherichia coli Biochemistry 2013 52:1828-1837 DOI:10.1021/bi4000244 PMID:23379331 PMCID:PMC3855549
- Wang, F., Sen, S., Zhang, Y., Ahmad, I., Zhu, X. Y., Wilson, I. A., Smider, V. V., Magliery, T. J., Schultz, P. G. Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation Proceedings of the National Academy of Sciences of the United States of America 2013 110:123-128 DOI:10.1073/pnas.1301810110 PMID:23440204 PMCID:PMC3600448
- Kazane, S. A., Axup, J. Y., Kim, C. H., Ciobanu, M., Wold, E. D., Barluenga, S., Hutchins, B. A., Schultz, P. G., Winssinger, N., Smider, V. V. Self-assembled antibody multimers through peptide nucleic acid conjugation Journal of the American Chemical Society 2013 135:340-346 DOI:10.1021/ja309505c PMID:23210862 PMCID:PMC3951380
- Chatterjee, A., Yang, P. Y., Soundararajan, G., Schultz, P. G. A tryptophanyl-tRNA synthetase/tRNA pair for unnatural amino acid mutagenesis in E. coli Angewandte Chemie-International Edition 2013 52:5106-5109 DOI:10.1002/anie.201301094 PMID:23554007
- Wang, F., Sambandan, D., Halder, R., Wang, J. N., Batt, S. M., Weinrick, B., Ahmad, I., Yang, P. Y., Zhang, Y., Kim, J., Hassani, M., Huszar, S., et al. Identification of a small molecule with activity against drug-resistant and persistent tuberculosis Proceedings of the National Academy of Sciences of the United States of America 2013 110:E2510-E2517 DOI:10.1073/pnas.1309171110 PMID:23776209 PMCID:PMC3703973
- Lairson, L. L., Lyssiotis, C. A., Zhu, S., Schultz, P. G. Small molecule-based approaches to adult stem cell therapies Annual Review of Pharmacology and Toxicology 2013 53:107-125 DOI:10.1146/annurev-pharmtox-011112-140300 PMID:23294307
- Shen, W., Tremblay, M. S., Deshmukh, V. A., Wang, W., Filippi, C. M., Harb, G., Zhang, Y. Q., Kamireddy, A., Baaten, J. E., Jin, Q., Swoboda, J. G., Cho, C. Y. Small-molecule inducer of β cell proliferation identified by high-throughput screening Journal of the American Chemical Society 2013 135:1669-1672 DOI:10.1021/ja309304m PMID:23330637
- Axup, J. Y., Bajjuri, K. M., Ritland, M., Hutchins, B. M., Kim, C. H., Kazane, S. A., Halder, R., Forsyth, J. S., Santidrian, A. F., Stafin, K., Lu, Y. C., Tran, H., et al. Synthesis of site-specific antibody-drug conjugates using unnatural amino acids Proceedings of the National Academy of Sciences of the United States of America 2012 109:16101-16106 DOI:10.1073/pnas.1211023109 PMID:22988081 PMCID:PMC3479532
- Chatterjee, A., Xiao, H., Schultz, P. G. Evolution of multiple, mutually orthogonal prolyl-tRNA synthetase/tRNA pairs for unnatural amino acid mutagenesis in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America 2012 109:14841-14846 DOI:10.1073/pnas.1212454109 PMID:22927411 PMCID:PMC3443146
- Hirota, T., Lee, J. W., St John, P. C., Sawa, M., Iwaisako, K., Noguchi, T., Pongsawakul, P. Y., Sonntag, T., Welsh, D. K., Brenner, D. A., Doyle, F. J., Schultz, P. G., et al. Identification of small molecule activators of cryptochrome Science 2012 337:1094-1097 DOI:10.1126/science.1223710 PMID:22798407 PMCID:PMC3589997
- Boitano, A. E., de Lichtervelde, L., Snead, J. L., Cooke, M. P., Schultz, P. G. An image-based screen identifies a small molecule regulator of megakaryopoiesis Proceedings of the National Academy of Sciences of the United States of America 2012 109:14019-14023 DOI:10.1073/pnas.1212545109 PMID:22891346 PMCID:PMC3435220
- de Lichtervelde, L., Antal, C. E., Boitano, A. E., Wang, Y., Krastel, P., Petersen, F., Newton, A. C., Cooke, M. P., Schultz, P. G. Euphohelioscopin A is a PKC activator capable of inducing macrophage differentiation Chemistry & Biology 2012 19:994-1000 DOI:10.1016/j.chembiol.2012.06.010 PMID:22921066 PMCID:PMC4079670
- Dubrovska, A., Hartung, A., Bouchez, L. C., Walker, J. R., Reddy, V. A., Cho, C. Y., Schultz, P. G. CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling British Journal of Cancer 2012 107:43-52 DOI:10.1038/bjc.2012.105 PMID:22644306 PMCID:PMC3389396
- Kim, C. H., Axup, J. Y., Dubrovska, A., Kazane, S. A., Hutchins, B. A., Wold, E. D., Smider, V. V., Schultz, P. G. Synthesis of bispecific antibodies using genetically encoded unnatural amino acids Journal of the American Chemical Society 2012 134:9918-9921 DOI:10.1021/ja303904e PMID:22642368 PMCID:PMC4299457
- Johnson, K., Zhu, S. T., Tremblay, M. S., Payette, J. N., Wang, J. N., Bouchez, L. C., Meeusen, S., Althage, A., Cho, C. Y., Wu, Xu, Schultz, P. G. A stem cell-based approach to cartilage repair Science 2012 336:717-721 DOI:10.1126/science.1215157 PMID:22491093
- Kazane, S. A., Sok, D., Cho, E. H., Uson, M. L., Kuhn, P., Schultz, P. G., Smider, V. V. Site-specific DNA-antibody conjugates for specific and sensitive immuno-PCR Proceedings of the National Academy of Sciences of the United States of America 2012 109:3731-3736 DOI:10.1073/pnas.1120682109 PMID:22345566 PMCID:PMC3309776
- Dubrovska, A., Elliott, J., Salamone, R. J., Telegeev, G. D., Stakhovsky, A. E., Schepotin, I. B., Yan, F., Wang, Y., Bouchez, L. C., Kularatne, S. A., Watson, J., Trussell, C., et al. CXCR4 expression in prostate cancer progenitor cells PLoS One 2012 7:e31226 DOI:10.1371/journal.pone.0031226 PMID:22359577 PMCID:PMC3281066
- Tianero, M. D. B., Donia, M. S., Young, T. S., Schultz, P. G., Schmidt, E. W. Ribosomal route to small-molecule diversity Journal of the American Chemical Society 2012 134:418-425 DOI:10.1021/ja208278k PMID:22107593 PMCID:PMC3268757
- Wang, D. L., Wang, J. N., Bonamy, G. M. C., Meeusen, S., Brusch, R. G., Turk, C., Yang, P. Y., Schultz, P. G. A small molecule promotes mitochondrial fusion in mammalian cells Angewandte Chemie-International Edition 2012 51:9302-9305 DOI:10.1002/anie.201204589 PMID:22907892
- Kim, C. H., Kang, M., Kim, H. J., Chatterjee, A., Schultz, P. G. Site-specific incorporation of ε-N-crotonyllysine into histones Angewandte Chemie-International Edition 2012 51:7246-7249 DOI:10.1002/anie.201203349 PMID:22689270 PMCID:PMC3783207
- Wang, F., Niu, W., Guo, J. T., Schultz, P. G. Unnatural amino acid mutagenesis of fluorescent proteins Angewandte Chemie-International Edition 2012 51:10132-10135 DOI:10.1002/anie.201204668 PMID:22951916
- Young, D. D., Jockush, S., Turro, N. J., Schultz, P. G. Synthetase polyspecificity as a tool to modulate protein function Bioorganic & Medicinal Chemistry Letters 2011 21:7502-7504 DOI:10.1016/j.bmcl.2011.09.108 PMID:22041062 PMCID:PMC3783217
- Meister, S., Plouffe, D. M., Kuhen, K. L., Bonamy, G. M. C., Wu, T., Barnes, S. W., Bopp, S. E., Borboa, R., Bright, A. T., Che, J. W., Cohen, S., Dharia, N. V., et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery Science 2011 334:1372-1377 DOI:10.1126/science.1211936 PMID:22096101 PMCID:PMC3473092
- Shoji, S., Dambacher, C. M., Shajani, Z., Williamson, J. R., Schultz, P. G. Systematic chromosomal deletion of bacterial ribosomal protein genes Journal of Molecular Biology 2011 413:751-761 DOI:10.1016/j.jmb.2011.09.004 PMID:21945294 PMCID:PMC3694390
- Nam, T. G., McNamara, C. W., Bopp, S., Dharia, N. V., Meister, S., Bonamy, G. M. C., Plouffe, D. M., Kato, N., McCormack, S., Bursulaya, B., Ke, H. J., Vaidya, A. B., et al. A chemical genomic analysis of decoquinate, a plasmodium falciparum cytochrome b inhibitor ACS Chemical Biology 2011 6:1214-1222 DOI:10.1021/cb200105d PMID:21866942 PMCID:PMC3220786
- Dubrovska, A., Kim, C., Elliott, J., Shen, W. J., Kuo, T. H., Koo, D. I., Li, C., Tuntland, T., Chang, J., Groessl, T., Wu, X., Gorney, V., et al. A chemically induced vaccine strategy for prostate cancer ACS Chemical Biology 2011 6:1223-1231 DOI:10.1021/cb200222s PMID:21936526
- Charbon, G., Wang, J. Y., Brustad, E., Schultz, P. G., Horwich, A. L., Jacobs-Wagner, C., Chapman, E. Localization of GroEL determined by in vivo incorporation of a fluorescent amino acid Bioorganic & Medicinal Chemistry Letters 2011 21:6067-6070 DOI:10.1016/j.bmcl.2011.08.057 PMID:21890355 PMCID:PMC3177974
- Minnihan, E. C., Young, D. D., Schultz, P. G., Stubbe, J. Incorporation of fluorotyrosines into ribonucleotide reductase using an evolved, polyspecific aminoacyl-tRNA synthetase Journal of the American Chemical Society 2011 133:15942-15945 DOI:10.1021/ja207719f PMID:21913683 PMCID:PMC3188361
- Berezhna, S. Y., Supekova, L., Sever, M. J., Schultz, P. G., Deniz, A. A. Dual regulation of hepatitis C viral RNA by cellular RNAi requires partitioning of Ago2 to lipid droplets and P-bodies RNA-a Publication of the RNA Society 2011 17:1831-1845 DOI:10.1261/rna.2523911 PMID:21868483 PMCID:PMC3185916
- Thielges, M. C., Axup, J. Y., Wong, D., Lee, H. S., Chung, J. K., Schultz, P. G., Fayer, M. D. Two-dimensional IR spectroscopy of protein dynamics using two vibrational labels: a site-specific genetically encoded unnatural amino acid and an active site ligand Journal of Physical Chemistry B 2011 115:11294-11304 DOI:10.1021/jp206986v PMID:21823631 PMCID:PMC3261801
- Li, J., Ding, S., Hsieh, M. H., Muneoka, K., Piamonte, V., Ng, N., Wu, X., Zhang, J., Liu, J., Glynne, R., Steffy, B. M., Schultz, P. G., et al. Regenerative phenotype in mice with a point mutation in transforming growth factor β type I receptor (TGFBR1) Proceedings of the National Academy of Sciences of the United States of America 2011 108:14560-14565 DOI:10.1073/pnas.1111056108 PMID:21841138 PMCID:PMC3167509
- Ai, H. W., Shen, W. J., Sagi, A., Chen, P. R., Schultz, P. G. Probing protein-protein interactions with a genetically encoded photo-crosslinking amino acid ChemBioChem 2011 12:1854-1857 DOI:10.1002/cbic.201100194 PMID:21678540
- Charbon, G., Brustad, E., Scott, K. A., Wang, J. Y., Lobner-Olesen, A., Schultz, P. G., Jacobs-Wagner, C., Chapman, E. Subcellular protein localization by using a genetically encoded fluorescent amino acid ChemBioChem 2011 12:1818-1821 DOI:10.1002/cbic.201100282 PMID:21681882 PMCID:PMC3175735
- Gauba, V., Grunewald, J., Gorney, V., Deaton, L. M., Kang, M. C., Bursulaya, B., Ou, W. J., Lerner, R. A., Schmedt, C., Geierstanger, B. H., Schultz, P. G., Ramirez-Montagut, T. Loss of CD4 T-cell-dependent tolerance to proteins with modified amino acids Proceedings of the National Academy of Sciences of the United States of America 2011 108:12821-12826 DOI:10.1073/pnas.1110042108 PMID:21768354 PMCID:PMC3150954
- Hannedouche, S., Zhang, J., Yi, T. S., Shen, W. J., Nguyen, D., Pereira, J. P., Guerini, D., Baumgarten, B. U., Roggo, S., Wen, B., Knochenmuss, R., Noel, S., et al. Oxysterols direct immune cell migration via EBI2 Nature 2011 475:524-527 DOI:10.1038/nature10280 PMID:21796212 PMCID:PMC4297623
- Young, T. S., Young, D. D., Ahmad, I., Louis, J. M., Benkovic, S. J., Schultz, P. G. Evolution of cyclic peptide protease inhibitors Proceedings of the National Academy of Sciences of the United States of America 2011 108:11052-11056 DOI:10.1073/pnas.1108045108 PMID:21690365 PMCID:PMC3131355
- Cho, H., Daniel, T., Buechler, Y. J., Litzinger, D. C., Maio, Z. W., Putnam, A. M. H., Kraynov, V. S., Sim, B. C., Bussell, S., Javahishvili, T., Kaphle, S., Viramontes, G., et al. Optimized clinical performance of growth hormone with an expanded genetic code Proceedings of the National Academy of Sciences of the United States of America 2011 108:9060-9065 DOI:10.1073/pnas.1100387108 PMID:21576502 PMCID:PMC3107295
- Nam, T. G., Lee, J., Walker, J. R., Brinker, A., Cho, C. Y., Schultz, P. G. Identification and characterization of small-molecule inducers of fetal hemoglobin ChemMedChem 2011 6:777-780 DOI:10.1002/cmdc.201000505 PMID:21416611
- Tao, H. Y., Jin, Q. H., Koo, D. I., Liao, X. B., Englund, N. P., Wang, Y., Ramamurthy, A., Schultz, P. G., Dorsch, M., Kelleher, J., Wu, X. Small molecule antagonists in distinct binding modes inhibit drug-resistant mutant of Smoothened Chemistry & Biology 2011 18:432-437 DOI:10.1016/j.chembiol.2011.01.018 PMID:21513879
- Bouchez, L. C., Boitano, A. E., de Lichtervelde, L., Romeo, R., Cooke, M. P., Schultz, P. G. Small-molecule regulators of human stem cell self-renewal ChemBioChem 2011 12:854-857 DOI:10.1002/cbic.201000734 PMID:21381174
- Hutchins, B. M., Kazane, S. A., Staflin, K., Forsyth, J. S., Felding-Habermann, B., Smider, V. V., Schultz, P. G. Selective formation of covalent protein heterodimers with an unnatural amino acid Chemistry & Biology 2011 18:299-303 DOI:10.1016/j.chembiol.2011.01.006 PMID:21439474 PMCID:PMC3694407
- Young, D. D., Young, T. S., Jahnz, M., Ahmad, I., Spraggon, G., Schultz, P. G. An evolved aminoacyl-tRNA synthetase with atypical polysubstrate specificity Biochemistry 2011 50:1894-1900 DOI:10.1021/bi101929e PMID:21280675 PMCID:PMC3694404
- Hutchins, B. M., Kazane, S. A., Staflin, K., Forsyth, J. S., Felding-Habermann, B., Schultz, P. G., Smider, V. V. Site-specific coupling and sterically controlled formation of multimeric antibody fab fragments with unnatural amino acids Journal of Molecular Biology 2011 406:595-603 DOI:10.1016/j.jmb.2011.01.011 PMID:21237172 PMCID:PMC4278757
- Lee, J. W., Hirota, T., Peters, E. C., Garcia, M., Gonzalez, R., Cho, C. Y., Wu, X., Schultz, P. G., Kay, S. A. A small molecule modulates circadian rhythms through phosphorylation of the period protein Angewandte Chemie-International Edition 2011 50:10608-10611 DOI:10.1002/anie.201103915 PMID:21954091 PMCID:PMC3755734
- Lyssiotis, C. A., Lairson, L. L., Boitano, A. E., Wurdak, H., Zhu, S. T., Schultz, P. G. Chemical control of stem cell fate and developmental potential Angewandte Chemie-International Edition 2011 50:200-242 DOI:10.1002/anie.201004284 PMID:21184400
- Gonzalez, R., Lee, J. W., Snyder, E. Y., Schultz, P. G. Dorsomorphin promotes human embryonic stem cell self-renewal Angewandte Chemie-International Edition 2011 50:3439-3441 DOI:10.1002/anie.201005659 PMID:21384475
- Staerk, J., Lyssiotis, C. A., Medeiro, L. A., Bollong, M., Foreman, R. K., Zhu, S. T., Garcia, M., Gao, Q., Bouchez, L. C., Lairson, L. L., Charette, B. D., Supekova, L. Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells Angewandte Chemie-International Edition 2011 50:5733-5735 DOI:10.1002/anie.201101042 PMID:21547985 PMCID:PMC3409461
- Gonzalez, R., Lee, J. W., Schultz, P. G. Stepwise chemically induced cardiomyocyte specification of human embryonic stem cells Angewandte Chemie-International Edition 2011 50:11181-11185 DOI:10.1002/anie.201103909 PMID:22191091
- Dubrovska, A., Elliott, J., Salamone, R. J., Kim, S., Aimone, L. J., Walker, J. R., Watson, J., Sauveur-Michel, M., Garcia-Echeverria, C., Cho, C. Y., Reddy, V. A., Schultz, P. G. Combination therapy targeting both tumor-initiating and differentiated cell populations in prostate carcinoma Clinical Cancer Research 2010 16:5692-5702 DOI:10.1158/1078-0432.ccr-10-1601 PMID:21138868
- Hirota, T., Lee, J. W., Lewis, W. G., Zhang, E. E., Breton, G., Liu, X. Z., Garcia, M., Peters, E. C., Etchegaray, J. P., Traver, D., Schultz, P. G., Kay, S. A. High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase PLoS Biology 2010 8:e1000559 DOI:10.1371/journal.pbio.1000559 PMID:21179498 PMCID:PMC3001897
- Boitano, A. E., Wang, J. A., Romeo, R., Bouchez, L. C., Parker, A. E., Sutton, S. E., Walker, J. R., Flaveny, C. A., Perdew, G. H., Denison, M. S., Schultz, P. G., Cooke, M. P. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells Science 2010 329:1345-1348 DOI:10.1126/science.1191536 PMID:20688981 PMCID:PMC3033342
- Hu, X. Y. V., Rodrigues, T. M. A., Tao, H. Y., Baker, R. K., Miraglia, L., Orth, A. P., Lyons, G. E., Schultz, P. G., Wu, X. Identification of RING finger protein 4 (RNF4) as a modulator of DNA demethylation through a functional genomics screen Proceedings of the National Academy of Sciences of the United States of America 2010 107:15087-15092 DOI:10.1073/pnas.1009025107 PMID:20696907 PMCID:PMC2930560
- Teo, H. L., Ghosh, S., Luesch, H., Ghosh, A., Wong, E. T., Malik, N., Orth, A., de Jesus, P., Perry, A. S., Oliver, J. D., Tran, N. L., Speiser, L. J., et al. Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression Nature Cell Biology 2010 12:758-767 DOI:10.1038/ncb2080 PMID:20622870
- Zhu, S. T., Wurdak, H., Schultz, P. G. Directed embryonic stem cell differentiation with small molecules Future Medicinal Chemistry 2010 2:965-973 DOI:10.4155/fmc.10.190 PMID:21426114
- Hur, W., Sun, Z., Jiang, T., Mason, D. E., Peters, E. C., Zhang, D. D., Luesch, H., Schultz, P. G., Grays, N. S. A small-molecule inducer of the antioxidant response element Chemistry & Biology 2010 17:537-547 DOI:10.1016/j.chembiol.2010.03.013 PMID:20534351
- Groff, D., Chen, P. R., Peters, F. B., Schultz, P. G. A genetically encoded ε-N-methyl lysine in mammalian cells ChemBioChem 2010 11:1066-1068 DOI:10.1002/cbic.200900690 PMID:20422671 PMCID:PMC2882943
- Young, T. S., Schultz, P. G. Beyond the canonical 20 amino acids: expanding the genetic lexicon Journal of Biological Chemistry 2010 285:11039-11044 DOI:10.1074/jbc.R109.091306 PMID:20147747 PMCID:PMC2856976
- Supekova, L., Supek, F., Greer, J. E., Schultz, P. G. A single mutation in the first transmembrane domain of yeast COX2 enables its allotopic expression Proceedings of the National Academy of Sciences of the United States of America 2010 107:5047-5052 DOI:10.1073/pnas.1000735107 PMID:20194738 PMCID:PMC2841951
- Gonzalez, R., Jennings, L. L., Knuth, M., Orth, A. P., Klock, H. E., Ou, W., Feuerhelm, J., Hull, M. V., Koesema, E., Wang, Y. P., Zhang, J., Wu, C. L., et al. Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency Proceedings of the National Academy of Sciences of the United States of America 2010 107:3552-3557 DOI:10.1073/pnas.0914019107 PMID:20133595 PMCID:PMC2840467
- Wang, F., Robbins, S., Guo, J. T., Shen, W. J., Schultz, P. G. Genetic incorporation of unnatural amino acids into proteins in Mycobacterium tuberculosis PLoS One 2010 5:e9354 DOI:10.1371/journal.pone.0009354 PMID:20179771 PMCID:PMC2825273
- Young, T. S., Ahmad, I., Yin, J. A., Schultz, P. G. An enhanced system for unnatural amino acid mutagenesis in E. coli Journal of Molecular Biology 2010 395:361-374 DOI:10.1016/j.jmb.2009.10.030 PMID:19852970
- Wurdak, H., Zhu, S. T., Romero, A., Lorger, M., Watson, J., Zhang, J., Chiang, C. Y., Natu, V. S., Lairson, L. L., Walker, J. R., Trussell, C. M., Harsh, G. R. An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation Cell Stem Cell 2010 6:37-47 DOI:10.1016/j.stem.2009.11.002 PMID:20085741
- Ai, H. W., Lee, J. W., Schultz, P. G. A method to site-specifically introduce methyllysine into proteins in E. coli Chemical Communications 2010 46:5506-5508 DOI:10.1039/c0cc00108b PMID:20571694 PMCID:PMC2928331
- Groff, D., Wang, F., Jockusch, S., Turro, N. J., Schultz, P. G. A new strategy to photoactivate green fluorescent protein Angewandte Chemie-International Edition 2010 49:7677-7679 DOI:10.1002/anie.201003797 PMID:20836111 PMCID:PMC2953579
- Wurdak, H., Zhu, S. T., Min, K. H., Aimone, L., Lairson, L. L., Watson, J., Chopiuk, G., Demas, J., Charette, B., Weerapana, E., Cravatt, B. F., Cline, H. T. A small molecule accelerates neuronal differentiation in the adult rat Proceedings of the National Academy of Sciences of the United States of America 2010 107:16542-16547 DOI:10.1073/pnas.1010300107 PMID:20823227 PMCID:PMC2944756
- Liu, C. C., Schultz, P. G. Adding new chemistries to the genetic code Annual Review of Biochemistry 2010 79:413-444 DOI:10.1146/annurev.biochem.052308.105824 PMID:20307192
- Ai, H. W., Shen, W. J., Brustad, E., Schultz, P. G. Genetically encoded alkenes in yeast Angewandte Chemie-International Edition 2010 49:935-937 DOI:10.1002/anie.200905590 PMID:20025009
- Jones, D. H., Cellitti, S. E., Hao, X. S., Zhang, Q., Jahnz, M., Summerer, D., Schultz, P. G., Uno, T., Geierstanger, B. H. Site-specific labeling of proteins with NMR-active unnatural amino acids Journal of Biomolecular NMR 2010 46:89-100 DOI:10.1007/s10858-009-9365-4 PMID:19669620
- Fleissner, M. R., Brustad, E. M., Kalai, T., Altenbach, C., Cascio, D., Peters, F. B., Hideg, K., Peuker, S., Schultz, P. G., Hubbell, W. L. Site-directed spin labeling of a genetically encoded unnatural amino acid Proceedings of the National Academy of Sciences of the United States of America 2009 106:21637-21642 DOI:10.1073/pnas.0912009106 PMID:19995976 PMCID:PMC2799802
- Jones, C. A., Nishiya, N., London, N. R., Zhu, W. Q., Sorensen, L. K., Chan, A. C., Lim, C. J., Chen, H. Y., Zhang, Q. S., Schultz, P. G., Thomas, K. R., Hayallah, A. M. Slit2-Robo4 signalling promotes vascular stability by blocking Arf6 activity Nature Cell Biology 2009 11:1325-1331 DOI:10.1038/ncb1976 PMID:19855388 PMCID:PMC2854659
- Zhu, S., Wurdak, H., Wang, Y., Galkin, A., Tao, H. Y., Li, J., Lyssiotis, C. A., Yan, F., Tu, B. P., Miraglia, L., Walker, J., Sun, F., et al. A genomic screen identifies TYRO3 as a MITF regulator in melanoma Proceedings of the National Academy of Sciences of the United States of America 2009 106:17025-17030 DOI:10.1073/pnas.0909292106 PMID:19805117 PMCID:PMC2761329
- Lemke, E. A., Gambin, Y., Vandelinder, V., Brustad, E. M., Liu, H. W., Schultz, P. G., Groisman, A., Deniz, A. A. Microfluidic device for single-molecule experiments with enhanced photostability Journal of the American Chemical Society 2009 131:13610-13612 DOI:10.1021/ja9027023 PMID:19772358 PMCID:PMC2779842
- Liu, C. C., Choe, H., Farzan, M., Smider, V. V., Schultz, P. G. Mutagenesis and evolution of sulfated antibodies using an expanded genetic code Biochemistry 2009 48:8891-8898 DOI:10.1021/bi9011429 PMID:19715291 PMCID:PMC2891052
- Lee, H. S., Guo, J. T., Lemke, E. A., Dimla, R. D., Schultz, P. G. Genetic incorporation of a small, environmentally sensitive, fluorescent probe into proteins in Saccharomyces cerevisiae Journal of the American Chemical Society 2009 131:12921-12923 DOI:10.1021/ja904896s PMID:19702307 PMCID:PMC2873857
- Wu, X., Schultz, P. G. Synthesis at the interface of chemistry and biology Journal of the American Chemical Society 2009 131:12497-12515 DOI:10.1021/ja9026067 PMID:19689159
- Mills, J. H., Lee, H. S., Liu, C. C., Wang, J. Y., Schultz, P. G. A genetically encoded direct sensor of antibody-antigen interactions ChemBioChem 2009 10:2162-2164 DOI:10.1002/cbic.200900254 PMID:19672911 PMCID:PMC2891037
- Lee, H. S., Dimla, R. D., Schultz, P. G. Protein-DNA photo-crosslinking with a genetically encoded benzophenone-containing amino acid Bioorganic & Medicinal Chemistry Letters 2009 19:5222-5224 DOI:10.1016/j.bmcl.2009.07.011 PMID:19643606 PMCID:PMC2873854
- Liu, C. C., Mack, A. V., Brustad, E. M., Mills, J. H., Groff, D., Smider, V. V., Schultz, P. G. Evolution of proteins with genetically encoded "chemical warheads" Journal of the American Chemical Society 2009 131:9616-9617 DOI:10.1021/ja902985e PMID:19555063 PMCID:PMC2745334
- Melancon, C. E., Schultz, P. G. One plasmid selection system for the rapid evolution of aminoacyl-tRNA synthetases Bioorganic & Medicinal Chemistry Letters 2009 19:3845-3847 DOI:10.1016/j.bmcl.2009.04.007 PMID:19398201 PMCID:PMC2714362
- Lyssiotis, C. A., Foreman, R. K., Staerk, J., Garcia, M., Mathur, D., Markoulaki, S., Hanna, J., Lairson, L. L., Charette, B. D., Bouchez, L. C., Bollong, M., Kunick, C., et al. Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4 Proceedings of the National Academy of Sciences of the United States of America 2009 106:8912-8917 DOI:10.1073/pnas.0903860106 PMID:19447925 PMCID:PMC2690053
- Zhu, S. T., Wurdak, H., Wang, J., Lyssiotis, C. A., Peters, E. C., Cho, C. Y., Wu, X., Schultz, P. G. A small molecule primes embryonic stem cells for differentiation Cell Stem Cell 2009 4:416-426 DOI:10.1016/j.stem.2009.04.001 PMID:19427291
- Young, T. S., Ahmad, I., Brock, A., Schultz, P. G. Expanding the genetic repertoire of the methylotrophic yeast Pichia pastoris Biochemistry 2009 48:2643-2653 DOI:10.1021/bi802178k PMID:19265424
- Grunewald, J., Hunt, G. S., Dong, L. Q., Niessen, F., Wen, B. G., Tsao, M. L., Perera, R., Kang, M. C., Laffitte, B. A., Azarian, S., Ruf, W., Nasoff, M., et al. Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids Proceedings of the National Academy of Sciences of the United States of America 2009 106:4337-4342 DOI:10.1073/pnas.0900507106 PMID:19246393 PMCID:PMC2657443
- Wikoff, W. R., Anfora, A. T., Liu, J., Schultz, P. G., Lesley, S. A., Peters, E. C., Siuzdak, G. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites Proceedings of the National Academy of Sciences of the United States of America 2009 106:3698-3703 DOI:10.1073/pnas.0812874106 PMID:19234110 PMCID:PMC2656143
- Peters, F. B., Brock, A., Wang, J. Y., Schultz, P. G. Photocleavage of the polypeptide backbone by 2-nitrophenylalanine Chemistry & Biology 2009 16:148-152 DOI:10.1016/j.chembiol.2009.01.013 PMID:19246005 PMCID:PMC2714363
- Lee, H. S., Spraggon, G., Schultz, P. G., Wang, F. Genetic incorporation of a metal-ion chelating amino acid into proteins as a biophysical probe Journal of the American Chemical Society 2009 131:2481-2483 DOI:10.1021/ja808340b PMID:19193005 PMCID:PMC2679636
- Lee, J., Hong, J. Y., Nam, T. G., Peters, E. C., Orth, A. P., Geierstanger, B. H., Goldfinger, L. E., Ginsberg, M. H., Cho, C. Y., Schultz, P. G. A small molecule inhibitor of α4 integrin-dependent cell migration Bioorganic & Medicinal Chemistry 2009 17:977-980 DOI:10.1016/j.bmc.2008.02.067 PMID:18329275 PMCID:PMC2951142
- Dubrovska, A., Kim, S., Salamone, R. J., Walker, J. R., Maira, S. M., Garcia-Echeverria, C., Schultz, P. G., Reddy, V. A. The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations Proceedings of the National Academy of Sciences of the United States of America 2009 106:268-273 DOI:10.1073/pnas.0810956106 PMID:19116269 PMCID:PMC2629188
- Chen, P. R., Groff, D., Guo, J. T., Ou, W. J., Cellitti, S., Geierstanger, B. H., Schultz, P. G. A facile system for encoding unnatural amino acids in mammalian cells Angewandte Chemie-International Edition 2009 48:4052-4055 DOI:10.1002/anie.200900683 PMID:19378306 PMCID:PMC2873846
- Liu, C. C., Cellitti, S. E., Geierstanger, B. H., Schultz, P. G. Efficient expression of tyrosine-sulfated proteins in E. coli using an expanded genetic code Nature Protocols 2009 4:1784-1789 DOI:10.1038/nprot.2009.188 PMID:20010929 PMCID:PMC2928070
- Groff, D., Thielges, M. C., Cellitti, S., Schultz, P. G., Romesberg, F. E. Efforts toward the direct experimental characterization of enzyme microenvironments: Tyrosine100 in dihydrofolate reductase Angewandte Chemie-International Edition 2009 48:3478-3481 DOI:10.1002/anie.200806239 PMID:19347910 PMCID:PMC3166254
- Guo, J. T., Melancon, C. E., Lee, H. S., Groff, D., Schultz, P. G. Evolution of amber suppressor tRNAs for efficient bacterial production of proteins containing nonnatural amino acids Angewandte Chemie-International Edition 2009 48:9148-9151 DOI:10.1002/anie.200904035 PMID:19856359 PMCID:PMC2887739
- Wang, W. D., Walker, J. R., Wang, X., Tremblay, M. S., Lee, J. W., Wu, X., Schultz, P. G. Identification of small-molecule inducers of pancreatic β-cell expansion Proceedings of the National Academy of Sciences of the United States of America 2009 106:1427-1432 DOI:10.1073/pnas.0811848106 PMID:19164755 PMCID:PMC2635822
- Umanah, G., Huang, L. Y., Schultz, P. G., Naider, F., Becker, J. M. Incorporation of the unnatural amino acid p-benzoyl-L-phenylalanine (Bpa) into a G protein-coupled receptor in its native context Advances in Experimental Medicine and Biology 2009 611:333-335 DOI:10.1007/978-0-387-73657-0_149 PMID:19400216
- Brustad, E. M., Lemke, E. A., Schultz, P. G., Deniz, A. A. A general and efficient method for the site-specific dual-labeling of proteins for single molecule fluorescence resonance energy transfer Journal of the American Chemical Society 2008 130:17664-17665 DOI:10.1021/ja807430h PMID:19108697 PMCID:PMC2743202
- Hirota, T., Lewis, W. G., Liu, A. C., Lee, J. W., Schultz, P. G., Kay, S. A. A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3β Proceedings of the National Academy of Sciences of the United States of America 2008 105:20746-20751 DOI:10.1073/pnas.0811410106 PMID:19104043 PMCID:PMC2606900
- Liu, C. C., Mack, A. V., Tsao, M. L., Mills, J. H., Lee, H. S., Choe, H., Farzan, M., Schultz, P. G., Smider, V. V. Protein evolution with an expanded genetic code Proceedings of the National Academy of Sciences of the United States of America 2008 105:17688-17693 DOI:10.1073/pnas.0809543105 PMID:19004806 PMCID:PMC2584696
- Brustad, E., Bushey, M. L., Brock, A., Chittuluru, J., Schultz, P. G. A promiscuous aminoacyl-tRNA synthetase that incorporates cysteine, methionine, and alanine homologs into proteins Bioorganic & Medicinal Chemistry Letters 2008 18:6004-6006 DOI:10.1016/j.bmcl.2008.09.050 PMID:18845434
- Lee, H. S., Schultz, P. G. Biosynthesis of a site-specific DNA cleaving protein Journal of the American Chemical Society 2008 130:13194-13195 DOI:10.1021/ja804653f PMID:18788806
- Gruenewald, J., Tsao, M. L., Perera, R., Dong, L. Q., Niessen, F., Wen, B. G., Kubitz, D. M., Smider, V. V., Ruf, W., Nasoff, M., Lerner, R. A., Schultz, P. G. Immunochemical termination of self-tolerance Proceedings of the National Academy of Sciences of the United States of America 2008 105:11276-11280 DOI:10.1073/pnas.0804157105 PMID:18685087 PMCID:PMC2516224
- Cellitti, S. E., Jones, D. H., Lagpacan, L., Hao, X. S., Zhang, Q., Hu, H. Y., Brittain, S. M., Brinker, A., Caldwell, J., Bursulaya, B., Spraggon, G., Brock, A., et al. In vivo incorporation of unnatural amino acids to probe structure, dynamics, and ligand binding in a large protein by nuclear magnetic resonance spectroscopy Journal of the American Chemical Society 2008 130:9268-9281 DOI:10.1021/ja801602q PMID:18576636 PMCID:PMC2562865
- Plouffe, D., Brinker, A., McNamara, C., Henson, K., Kato, N., Kuhen, K., Nagle, A., Adrian, F., Matzen, J. T., Anderson, P., Nam, T. G., Gray, N. S., et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen Proceedings of the National Academy of Sciences of the United States of America 2008 105:9059-9064 DOI:10.1073/pnas.0802982105 PMID:18579783 PMCID:PMC2440361
- Kato, N., Sakata, T., Breton, G., Le Roch, K. G., Nagle, A., Andersen, C., Bursulaya, B., Henson, K., Johnson, J., Kumar, K. A., Marr, F., Mason, D., et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility Nature Chemical Biology 2008 4:347-356 DOI:10.1038/nchembio.87 PMID:18454143
- Debler, E. W., Kaufmann, G. F., Meijler, M. M., Heine, A., Mee, J. M., Pljevaljcic, G., Di Bilio, A. J., Schultz, P. G., Millar, D. P., Janda, K. D., Wilson, I. A., Gray, H. B., et al. Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex Science 2008 319:1232-1235 DOI:10.1126/science.1153445 PMID:18309081
- Graziano, J. J., Liu, W. S., Perera, R., Geierstanger, B. H., Lesley, S. A., Schultz, P. G. Selecting folded proteins from a library of secondary structural elements Journal of the American Chemical Society 2008 130:176-185 DOI:10.1021/ja074405w PMID:18067292 PMCID:PMC2714538
- Supekova, L., Supek, F., Lee, J., Chen, S., Gray, N., Pezacki, J. P., Schlapbach, A., Schultz, P. G. Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening Journal of Biological Chemistry 2008 283:29-36 DOI:10.1074/jbc.M703988200 PMID:17951261
- Brustad, E., Bushey, M. L., Lee, J. W., Groff, D., Liu, W., Schultz, P. G. A genetically encoded boronate-containing amino acid Angewandte Chemie-International Edition 2008 47:8220-8223 DOI:10.1002/anie.200803240 PMID:18816552 PMCID:PMC2873848
- Guo, J. T., Wang, J. Y., Anderson, J. C., Schultz, P. G. Addition of an alpha-hydroxy acid to the genetic code of bacteria Angewandte Chemie-International Edition 2008 47:722-725 DOI:10.1002/anie.200704074 PMID:18069708
- Guo, J. T., Wang, J. Y., Lee, J. S., Schultz, P. G. Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins Angewandte Chemie-International Edition 2008 47:6399-6401 DOI:10.1002/anie.200802336 PMID:18624319
- Tippmann, E. M., Liu, W., Summerer, D., Mack, A. V., Schultz, P. G. A genetically encoded diazirine photocrosslinker in Escherichia coli ChemBioChem 2007 8:2210-2214 DOI:10.1002/cbic.200700460 PMID:18000916
- Seyedsayamdost, M. R., Xie, J., Chan, C. T. Y., Schultz, P. G., Stubbe, J. Site-specific insertion of 3-aminotyrosine into subunit α2 of E. coli ribonucleotide reductase: direct evidence for involvement of Y(730) and Y(731) in radical propagation Journal of the American Chemical Society 2007 129:15060-15071 DOI:10.1021/ja076043y PMID:17990884
- Lemke, E. A., Summerer, D., Geierstanger, B. H., Brittain, S. M., Schultz, P. G. Control of protein phosphorylation with a genetically encoded photocaged amino acid Nature Chemical Biology 2007 3:769-772 DOI:10.1038/nchembio.2007.44 PMID:17965709
- Lee, J., Wu, X., di Magliano, M. P., Peters, E. C., Wang, Y., Hong, J., Hebrok, M., Din, S., Cho, C. Y., Schultz, P. G. A small-molecule antagonist of the hedgehog signaling pathway ChemBioChem 2007 8:1916-1919 DOI:10.1002/cbic.200700403 PMID:17886323
- Lyssiotis, C. A., Walker, J., Wu, C. L., Kondo, T., Schultz, P. G., Wu, X. Inhibition of histone deacetylase activity induces developmental plasticity in oligodendrocyte precursor cells Proceedings of the National Academy of Sciences of the United States of America 2007 104:14982-14987 DOI:10.1073/pnas.0707044104 PMID:17855562 PMCID:PMC1986599
- Trisler, K., Looger, L. L., Sharma, V., Baker, M., Benson, D. E., Trauger, S., Schultz, P. G., Smider, V. V. A metalloantibody that irreversibly binds a protein antigen Journal of Biological Chemistry 2007 282:26344-26353 DOI:10.1074/jbc.M704675200 PMID:17617633
- Liu, C. C., Brustad, E., Liu, W. S., Schultz, P. G. Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin Journal of the American Chemical Society 2007 129:10648-10649 DOI:10.1021/ja0735002 PMID:17685615 PMCID:PMC2530905
- Matsuda, S., Fillo, J. D., Henry, A. A., Rai, P., Wilkens, S. J., Dwyer, T. J., Geierstanger, B. H., Wemmer, D. E., Schultz, P. G., Spraggon, G., Romesberg, F. E. Efforts toward expansion of the genetic alphabet: structure and replication of unnatural base pairs Journal of the American Chemical Society 2007 129:10466-10473 DOI:10.1021/ja072276d PMID:17685517 PMCID:PMC2536688
- Chen, S., Schultz, P. G., Brock, A. An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae Journal of Molecular Biology 2007 371:112-122 DOI:10.1016/j.jmb.2007.05.017 PMID:17560600
- Dierks, C., Grbic, J., Zirlik, K., Beigi, R., Englund, N. P., Guo, G. R., Veelken, H., Engelhardt, M., Mertelsmann, R., Kelleher, J. F., Schultz, P., Warmuth, M. Essential role of stromally induced hedgehog signaling in B-cell malignancies Nature Medicine 2007 13:944-951 DOI:10.1038/nm1614 PMID:17632527
- Tippmann, E. M., Schultz, P. G. A genetically encoded metallocene containing amino acid Tetrahedron 2007 63:6182-6184 DOI:10.1016/j.tet.2007.02.125
- Xie, J. M., Supekova, L., Schultz, P. G. A genetically encoded metabolically stable analogue of phosphotyrosine in Escherichia coli ACS Chemical Biology 2007 2:474-478 DOI:10.1021/cb700083w PMID:17622177
- Chen, S., Takanashi, S. C., Zhang, Q. S., Xiong, W., Zhu, S. T., Peters, E. C., Ding, S., Schultz, P. G. Reversine increases the plasticity of lineage-committed mammalian cells Proceedings of the National Academy of Sciences of the United States of America 2007 104:10482-10487 DOI:10.1073/pnas.0704360104 PMID:17566101 PMCID:PMC1965539
- Gumireddy, K., Sun, F. X., Klein-Szanto, A. J., Gibbins, J. M., Gimotty, P. A., Saunders, A. J., Schultz, P. G., Huang, Q. H. In vivo selection for metastasis promoting genes in the mouse Proceedings of the National Academy of Sciences of the United States of America 2007 104:6696-6701 DOI:10.1073/pnas.0701145104 PMID:17420453 PMCID:PMC1871848
- Liu, Y. X., Kern, J. T., Walker, J. R., Johnson, J. A., Schultz, P. G., Luesch, H. A genomic screen for activators of the antioxidant response element Proceedings of the National Academy of Sciences of the United States of America 2007 104:5205-5210 DOI:10.1073/pnas.0700898104 PMID:17360324 PMCID:PMC1829287
- Liu, W. S., Brock, A., Chen, S., Chen, S., Schultz, P. G. Genetic incorporation of unnatural amino acids into proteins in mammalian cells Nature Methods 2007 4:239-244 DOI:10.1038/nmeth1016 PMID:17322890
- Hong, J. Y., Lee, J., Min, K. H., Walker, J. R., Peters, E. C., Gray, N. S., Cho, C. Y., Schultz, P. G. Identification and characterization of small-molecule inducers of epidermal keratinocyte differentiation ACS Chemical Biology 2007 2:171-175 DOI:10.1021/cb600435t PMID:17348628
- Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F., Patapoutian, A. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines Nature 2007 445:541-545 DOI:10.1038/nature05544 PMID:17237762
- Galkin, A. V., Mellnick, J. S., Kim, S., Hood, T. L., Li, N. X., Li, L. T., Xia, G., Steensma, R., Chopiuk, G., Jiang, J. Q., Wan, Y. Q., Ding, P., et al. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK Proceedings of the National Academy of Sciences of the United States of America 2007 104:270-275 DOI:10.1073/pnas.0609412103 PMID:17185414 PMCID:PMC1765448
- Wang, J., Schiller, S. M., Schultz, P. G. A biosynthetic route to dehydroalanine-containing proteins Angewandte Chemie-International Edition 2007 46:6849-6851 DOI:10.1002/anie.200702305 PMID:17685371
- Xie, J. M., Liu, W. S., Schultz, P. G. A genetically encoded bidentate, metal-binding amino acid Angewandte Chemie-International Edition 2007 46:9239-9242 DOI:10.1002/anie.200703397 PMID:17893898
- Zhang, Q. S., Major, M. B., Takanashi, S., Camp, N. D., Nishiya, N., Peters, E. C., Ginsberg, M. H., Schultz, P. G., Moon, R. T., Ding, S. Small-molecule synergist of the Wnt/beta-catenin signaling pathway Proceedings of the National Academy of Sciences of the United States of America 2007 104:7444-7448 DOI:10.1073/pnas.0702136104 PMID:17460038 PMCID:PMC1863490
- Liu, W. S., Alfonta, L., Mack, A. V., Schultz, P. G. Structural basis for the recognition of para-benzoyl-L-phenylalanine by evolved aminoacyl-tRNA synthetases Angewandte Chemie-International Edition 2007 46:6073-6075 DOI:10.1002/anie.200701990 PMID:17628477
- Mukherji, M., Brill, L. M., Ficarro, S. B., Hampton, G. M., Schultz, P. G. A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways Biochemistry 2006 45:15529-15540 DOI:10.1021/bi060971c PMID:17176074
- Chen, S., Do, J. T., Zhang, Q. S., Yao, S. Y., Yan, F., Peters, E. C., Scholer, H. R., Schultz, P. G., Ding, S. Self-renewal of embryonic stem cells by a small molecule Proceedings of the National Academy of Sciences of the United States of America 2006 103:17266-17271 DOI:10.1073/pnas.0608156103 PMID:17088537 PMCID:PMC1859921
- Schultz, K. C., Supekova, L., Ryu, Y. H., Xie, J. M., Perera, R., Schultz, P. G. A genetically encoded infrared probe Journal of the American Chemical Society 2006 128:13984-13985 DOI:10.1021/ja0636690 PMID:17061854
- Liu, C. C., Schultz, P. G. Recombinant expression of selectively sulfated proteins in Escherichia coli Nature Biotechnology 2006 24:1436-1440 DOI:10.1038/nbt1254 PMID:17072302
- Zeng, H. Q., Xie, J., Schultz, P. G. Genetic introduction of a diketone-containing amino acid into proteins Bioorganic & Medicinal Chemistry Letters 2006 16:5356-5359 DOI:10.1016/j.bmcl.2006.07.094 PMID:16934461
- Mukherji, M., Bell, R., Supekova, L., Wang, Y., Orth, A. P., Batalov, S., Miraglia, L., Huesken, D., Lange, J., Sahasrabudhe, S., Reinhardt, M., Natt, F. Genome-wide functional analysis of human cell-cycle regulators Proceedings of the National Academy of Sciences of the United States of America 2006 103:14819-14824 DOI:10.1073/pnas.0604320103 PMID:17001007 PMCID:PMC1595435
- Xie, J. M., Schultz, P. G. A chemical toolkit for proteins: an expanded genetic code Nature Reviews Molecular Cell Biology 2006 7:775-782 DOI:10.1038/nrm2005 PMID:16926858
- Wang, J. Y., Xie, J. M., Wu, N., Schultz, P. G. A genetically encoded fluorescent amino acid Journal of the American Chemical Society 2006 128:8738-8739 DOI:10.1021/ja062666k PMID:16819861
- Summerer, D., Chen, S., Deiters, A., Chin, J. W., Schultz, P. G. A genetically encoded fluorescent amino acid Proceedings of the National Academy of Sciences of the United States of America 2006 103:9785-9789 DOI:10.1073/pnas.0603965103 PMID:16785423 PMCID:PMC1502531
- Berezhna, S. Y., Supekova, L., Supev, F., Schultz, P. G., Deniz, A. A. siRNA in human cells selectively localizes to target RNA sites Proceedings of the National Academy of Sciences of the United States of America 2006 103:7682-7687 DOI:10.1073/pnas.0600148103 PMID:16684885 PMCID:PMC1472505
- Cho, C. Y., Koo, S. H., Wang, Y., Callaway, S., Hedrick, S., Mak, P. A., Orth, A. P., Peters, E. C., Saez, E., Montminy, M., Schultz, P. G., Chanda, S. K. Identification of the tyrosine phosphatase PTP-MEG2 as an antagonist of hepatic insulin signaling Cell Metabolism 2006 3:367-378 DOI:10.1016/j.cmet.2006.03.006 PMID:16679294
- Saraf-Levy, T., Santoro, S. W., Volpin, H., Kushnirsky, T., Eyal, Y., Schultz, P. G., Gidoni, D., Carmi, N. Site-specific recombination of asymmetric lox sites mediated by a heterotetrameric Cre recombinase complex Bioorganic & Medicinal Chemistry 2006 14:3081-3089 DOI:10.1016/j.bmc.2005.12.016 PMID:16412655
- Turner, J. M., Graziano, J., Spraggon, G., Schultz, P. G. Structural plasticity of an aminoacyl-tRNA synthetase active site Proceedings of the National Academy of Sciences of the United States of America 2006 103:6483-6488 DOI:10.1073/pnas.0601756103 PMID:16618920 PMCID:PMC1458910
- Tsao, M. L., Summerer, D., Ryu, Y. H., Schultz, P. G. The genetic incorporation of a distance probe into proteins in Escherichia coli Journal of the American Chemical Society 2006 128:4572-4573 DOI:10.1021/ja058262u PMID:16594684
- Ryu, Y. H., Schultz, P. G. Efficient incorporation of unnatural amino acids into proteins in Escherichia coli Nature Methods 2006 3:263-265 DOI:10.1038/nmeth864 PMID:16554830
- Collins, C. S., Hong, J. Y., Sapinoso, L., Zhou, Y. Y., Liu, Z., Micklash, K., Schultz, P. G., Hampton, G. M. A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase Proceedings of the National Academy of Sciences of the United States of America 2006 103:3775-3780 DOI:10.1073/pnas.0600040103 PMID:16537454 PMCID:PMC1383649
- Luesch, H., Chanda, S. K., Raya, R. M., DeJesus, P., Orth, A. P., Walker, J. R., Belmonte, J. C. I., Schultz, P. G. A functional genomics approach to the mode of action of apratoxin A Nature Chemical Biology 2006 2:158-167 DOI:10.1038/nchembio769 PMID:16474387
- Melnick, J. S., Janes, J., Kim, S., Chang, J. Y., Sipes, D. G., Gunderson, D., Jarnes, L., Matzen, J. T., Garcia, M. E., Hood, T. L., Beigi, R., Xia, G., et al. An efficient rapid system for profiling the cellular activities of molecular libraries Proceedings of the National Academy of Sciences of the United States of America 2006 103:3153-3158 DOI:10.1073/pnas.0511292103 PMID:16492761 PMCID:PMC1413928
- Sagan, S. M., Rouleau, Y., Leggiadro, C., Supekova, L., Schultz, P. G., Su, A. I., Pezacki, J. P. The influence of cholesterol and lipid metabolism on host cell structure and hepatitis C virus replication Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire 2006 84:67-79 DOI:10.1139/o05-149 PMID:16462891
- Bose, M., Groff, D., Xie, J. M., Brustad, E., Schultz, P. G. The incorporation of a photoisomerizable amino acid into proteins in E. coli Journal of the American Chemical Society 2006 128:388-389 DOI:10.1021/ja055467u PMID:16402807
- Wang, L., Xie, J., Schultz, P. G. Expanding the genetic code Annual Review of Biophysics 2006 35:225-249 DOI:10.1146/annurev.biophys.35.101105.121507
- Deiters, A., Groff, D., Ryu, Y. H., Xie, J. M., Schultz, P. G. A genetically encoded photocaged tyrosine Angewandte Chemie-International Edition 2006 45:2728-2731 DOI:10.1002/anie.200600264 PMID:16548032
- Warashina, M., Min, K. H., Kuwabara, T., Huynh, A., Gage, F. H., Schultz, P. G., Ding, S. A synthetic small molecule that induces neuronal differentiation of adult hippocampal neural progenitor cells Angewandte Chemie-International Edition 2006 45:591-593 DOI:10.1002/anie.200503089 PMID:16323231
- Lowery, T. J., Garcia, S., Chavez, L., Ruiz, E. J., Wu, T., Brotin, T., Dutasta, J. P., King, D. S., Schultz, P. G., Pines, A., Wemmer, D. E. Optimization of xenon biosensors for detection of protein interactions ChemBioChem 2006 7:65-73 DOI:10.1002/cbic.200500327 PMID:16342304
- Tian, T., Debler, E. W., Millar, D. P., Deniz, A. A., Wilson, I. A., Schultz, P. G. The effects of antibodies on stilbene excited-state energetics Angewandte Chemie-International Edition 2006 45:7763-7765 DOI:10.1002/anie.200602720 PMID:17089439
- Xie, J. M., Schultz, P. G. Adding amino acids to the genetic repertoire Current Opinion in Chemical Biology 2005 9:548-554 DOI:10.1016/j.cbpa.2005.10.011 PMID:16260173
- Tsao, M. L., Tian, F., Schultz, P. G. Selective Staudinger modification of proteins containing p-azidophenylalanine ChemBioChem 2005 6:2147-2149 DOI:10.1002/cbic.200500314 PMID:16317766
- Turner, J. M., Graziano, J., Spraggon, G., Schultz, P. G. Structural characterization of a p-acetylphenylalanyl aminoacyl-tRNA synthetase Journal of the American Chemical Society 2005 127:14976-14977 DOI:10.1021/ja0549042 PMID:16248607
- Willingham, A. T., Orth, A. P., Batalov, S., Peters, E. C., Wen, B. G., Aza-Blanc, P., Hogenesch, J. B., Schultz, P. G. A strategy for probing the function of noncoding RNAs finds a repressor of NFAT Science 2005 309:1570-1573 DOI:10.1126/science.1115901 PMID:16141075
- Xie, J. M., Schultz, P. G. An expanding genetic code Methods 2005 36:227-238 DOI:10.1016/j.ymeth.2005.04.010 PMID:16076448
- Zhang, Y., Wang, L., Schultz, P. G., Wilson, I. A. Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine Protein Science 2005 14:1340-1349 DOI:10.1110/ps.041239305 PMID:15840835 PMCID:PMC2253270
- Deiters, A., Schultz, P. G. In vivo incorporation of an alkyne into proteins in Escherichia coli Bioorganic & Medicinal Chemistry Letters 2005 15:1521-1524 DOI:10.1016/j.bmcl.2004.12.065 PMID:15713420
- Liu, J., Bang, A. G., Kintner, C., Orth, A. P., Chanda, S. K., Ding, S., Schultz, P. G. Identification of the Wnt signaling activator leucine-rich repeat in flightless interaction protein 2 by a genome-wide functional analysis Proceedings of the National Academy of Sciences of the United States of America 2005 102:1927-1932 DOI:10.1073/pnas.0409472102 PMID:15677333 PMCID:PMC548559
- Luesch, H., Wu, T. Y. H., Ren, P. D., Gray, N. S., Schultz, P. G., Supek, F. A genome-wide overexpression screen in yeast for small-molecule target identification Chemistry & Biology 2005 12:55-63 DOI:10.1016/j.chembiol.2004.10.015 PMID:15664515
- Liu, J., Wu, X., Mitchell, B., Kintner, C., Ding, S., Schultz, P. G. A small-molecule agonist of the Wnt signaling pathway Angewandte Chemie-International Edition 2005 44:1987-1990 DOI:10.1002/anie.200462552 PMID:15724259
- Wang, L., Schultz, P. G. Expanding the genetic code Angewandte Chemie-International Edition 2005 44:34-66 DOI:10.1002/anie.200460627
- Deiters, A., Geierstanger, B. H., Schultz, P. G. Site-specific in vivo labeling of proteins for NMR studies ChemBioChem 2005 6:55-58 DOI:10.1002/cbic.200400319 PMID:15549724
- Ding, S., Schultz, P. G. Small molecules and future regenerative medicine Current Topics in Medicinal Chemistry 2005 5:383-396 DOI:10.2174/1568026053828402 PMID:15892681
- Venkateshrao, S., Yin, J., Jarzecki, A. A., Schultz, P. G., Spiro, T. G. Porphyrin distortion during affinity maturation of a ferrochelatase antibody, monitored by resonance Raman spectroscopy Journal of the American Chemical Society 2004 126:16361-16367 DOI:10.1021/ja0465395 PMID:15600337
- Feng, T., Tsao, M. L., Schultz, P. G. A phage display system with unnatural amino acids Journal of the American Chemical Society 2004 126:15962-15963 DOI:10.1021/ja045673m PMID:15584720
- Deiters, A., Cropp, T. A., Summerer, D., Mukherji, M., Schultz, P. G. Site-specific pegylation of proteins containing unnatural amino acids Bioorganic & Medicinal Chemistry Letters 2004 14:5743-5745 DOI:10.1016/j.bmcl.2004.09.059 PMID:15501033
- Cropp, T. A., Schultz, P. G. An expanding genetic code Trends in Genetics 2004 20:625-630 DOI:10.1016/j.tig.2004.09.013 PMID:15522458
- Spence, M. M., Ruiz, E. J., Rubin, S. M., Lowery, T. J., Winssinger, N., Schultz, P. G., Wemmer, D. E., Pines, A. Development of a functionalized xenon biosensor Journal of the American Chemical Society 2004 126:15287-15294 DOI:10.1021/ja0483037 PMID:15548026
- Wu, N., Deiters, A., Cropp, T. A., King, D., Schultz, P. G. A genetically encoded photocaged amino acid Journal of the American Chemical Society 2004 126:14306-14307 DOI:10.1021/ja040175z PMID:15521721
- Xie, J. M., Wang, L., Wu, N., Brock, A., Spraggon, G., Schultz, P. G. The site-specific incorporation of p-iodo-L-phenylalanine into proteins for structure determination Nature Biotechnology 2004 22:1297-1301 DOI:10.1038/nbt1013 PMID:15378068
- Wu, X., Walker, J., Zhang, J., Ding, S., Schultz, P. G. Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway Chemistry & Biology 2004 11:1229-1238 DOI:10.1016/j.chembiol.2004.06.010 PMID:15380183
- Williams, B., Watanabe, C. M. H., Schultz, P. G., Rimbach, G., Krucker, T. Age-related effects of Ginkgo biloba extract on synaptic plasticity and excitability Neurobiology of Aging 2004 25:955-962 DOI:10.1016/j.neurobiolaging.2003.10.008 PMID:15212849
- Ding, S., Schultz, P. G. A role for chemistry in stem cell biology Nature Biotechnology 2004 22:833-840 DOI:10.1038/nbt987 PMID:15229546
- Schlieker, C., Weibezahn, J., Patzelt, H., Tessarz, P., Strub, C., Zeth, K., Erbse, A., Schneider-Mergener, J., Chin, J. W., Schultz, P. G., Bukau, B., Mogk, A. Substrate recognition by the AAA+ chaperone ClpB Nature Structural & Molecular Biology 2004 11:607-615 DOI:10.1038/nsmb787 PMID:15208691
- Torres, F. E., Kuhnt, P., De Bruyker, D., Bell, A. G., Wolkin, M. V., Peeters, E., Williamson, J. R., Anderson, G. B., Schmitz, G. P., Recht, M. I., Schweizer, S., Scott, L. G., et al. Enthalpy arrays Proceedings of the National Academy of Sciences of the United States of America 2004 101:9517-9522 DOI:10.1073/pnas.0403573101 PMID:15210951 PMCID:PMC470707
- Zhang, Z. W., Alfonta, L., Tian, F., Bursulaya, B., Uryu, S., King, D. S., Schultz, P. G. Selective incorporation of 5-hydroxytryptophan into proteins in mammalian cells Proceedings of the National Academy of Sciences of the United States of America 2004 101:8882-8887 DOI:10.1073/pnas.0307029101 PMID:15187228 PMCID:PMC428441
- Anderson, J. C., Wu, N., Santoro, S. W., Lakshman, V., King, D. S., Schultz, P. G. An expanded genetic code with a functional quadruplet codon Proceedings of the National Academy of Sciences of the United States of America 2004 101:7566-7571 DOI:10.1073/pnas.0401517101 PMID:15138302 PMCID:PMC419646
- Yin, J., Mills, J. H., Schultz, P. G. A catalysis-based selection for peroxidase antibodies with increased activity Journal of the American Chemical Society 2004 126:3006-3007 DOI:10.1021/ja039198o PMID:15012103
- Huang, Q. H., Raya, A., DeJesus, P., Chao, S. H., Quon, K. C., Caldwell, J. S., Chanda, S. K., Izpisua-Belmonte, J. C., Schultz, P. G. Identification of p53 regulators by genome-wide functional analysis Proceedings of the National Academy of Sciences of the United States of America 2004 101:3456-3461 DOI:10.1073/pnas.0308562100 PMID:14990790 PMCID:PMC373483
- Wu, X., Ding, S., Ding, G., Gray, N. S., Schultz, P. G. Small molecules that induce cardiomyogenesis in embryonic stem cells Journal of the American Chemical Society 2004 126:1590-1591 DOI:10.1021/ja038950i PMID:14871063
- Zimmermann, N., Meggers, E., Schultz, P. G. A second-generation copper(II)-mediated metallo-DNA-base pair Bioorganic Chemistry 2004 32:13-25 DOI:10.1016/j.bioorg.2003.09.001 PMID:14700559
- Chen, S., Zhang, Q. S., Wu, X., Schultz, P. G., Ding, S. Dedifferentiation of lineage-committed cells by a small molecule Journal of the American Chemical Society 2004 126:410-411 DOI:10.1021/ja037390k PMID:14719906
- Wu, T. Y. H., Hassig, C., Wu, Y. Q., Ding, S., Schultz, P. G. Design, synthesis, and activity of HDAC inhibitors with a N-formyl hydroxylamine head group Bioorganic & Medicinal Chemistry Letters 2004 14:449-453 DOI:10.1016/j.bmcl.2003.10.055 PMID:14698179
- Zhang, Z. W., Gildersleeve, J., Yang, Y. Y., Xu, R., Loo, J. A., Uryu, S., Wong, C. H., Schultz, P. G. A new strategy for the synthesis of glycoproteins Science 2004 303:371-373 DOI:10.1126/science.1089509 PMID:14726590
- Zheng, L. X., Liu, J., Batalov, S., Zhou, D. M., Orth, A., Ding, S., Schultz, P. G. An approach to genomewide screens of expressed small interfering RNAs in mammalian cells Proceedings of the National Academy of Sciences of the United States of America 2004 101:135-140 DOI:10.1073/pnas.2136685100 PMID:14688408 PMCID:PMC314151
- Wignall, S. M., Gray, N. S., Chang, Y. T., Juarez, L., Jacob, R., Burlingame, A., Schultz, P. G., Heald, R. Identification of a novel protein regulating microtubule stability through a chemical approach Chemistry & Biology 2004 11:135-146 DOI:10.1016/j.chembiol.2003.12.019 PMID:15113003
- Alfonta, L., Zhang, Z. W., Uryu, S., Loo, J. A., Schultz, P. G. Site-specific incorporation of a redox-active amino acid into proteins Journal of the American Chemical Society 2003 125:14662-14663 DOI:10.1021/ja038242x PMID:14640614
- Santoro, S. W., Anderson, J. C., Lakshman, V., Schultz, P. G. An archaebacteria-derived glutamyl-tRNA synthetase and tRNA pair for unnatural amino acid mutagenesis of proteins in Escherichia coli Nucleic Acids Research 2003 31:6700-6709 DOI:10.1093/nar/gkg903 PMID:14627803 PMCID:PMC290271
- Lowery, T. J., Rubin, S. M., Ruiz, E. J., Spence, M. M., Winssinger, N., Schultz, P. G., Pines, A., Wemmer, D. E. Applications of laser-polarized (129)Xe to biomolecular assays Magnetic Resonance Imaging 2003 21:1235-1239 DOI:10.1016/j.mri.2003.08.025 PMID:14725931
- Esaki, M., Kanamori, T., Nishikawa, S., Shin, I., Schultz, P. G., Endo, T. Tom40 protein import channel binds to non-native proteins and prevents their aggregation Nature Structural Biology 2003 10:988-994 DOI:10.1038/nsb1008 PMID:14595396
- Schultz, P. G. Commentary on combinatorial chemistry Applied Catalysis A-General 2003 254:3-4 DOI:10.1016/s0926-860x(03)00258-8
- Baldwin, E. P., Martin, S. S., Abel, J., Gelato, K. A., Kim, H., Schultz, P. G., Santoro, S. W. A specificity switch in selected Cre recombinase variants is mediated by macromolecular plasticity and water Chemistry & Biology 2003 10:1085-1094 DOI:10.1016/j.chembiol.2003.10.015 PMID:14652076
- Mirotsou, M., Watanabe, C. M. H., Schultz, P. G., Pratt, R. E., Dzau, V. J. Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach Physiological Genomics 2003 15:115-126 DOI:10.1152/physiolgenomics.00071.2003 PMID:12902547
- Chanda, S. K., White, S., Orth, A. P., Reisdorph, R., Miraglia, L., Thomas, R. S., DeJesus, P., Mason, D. E., Huang, Q. H., Vega, R., Yu, D. H., Nelson, C. G., et al. Genome-scale functional profiling of the mammalian AP-1 signaling pathway Proceedings of the National Academy of Sciences of the United States of America 2003 100:12153-12158 DOI:10.1073/pnas.1934839100 PMID:14514886 PMCID:PMC218728
- Wu, T. Y. H., Schultz, P. G., Ding, S. One-pot two-step microwave-assisted reaction in constructing 4,5-disubstituted pyrazolopyrimidines Organic Letters 2003 5:3587-3590 DOI:10.1021/ol035226w PMID:14507179
- Deiters, A., Cropp, T. A., Mukherji, M., Chin, J. W., Anderson, J. C., Schultz, P. G. Adding amino acids with novel reactivity to the genetic code of Saccharomyces cerevisiae Journal of the American Chemical Society 2003 125:11782-11783 DOI:10.1021/ja0370037 PMID:14505376
- Li, S. Y., Cutler, G., Liu, J. J. J., Hoey, T., Chen, L. B., Schultz, P. G., Liao, J. Y., Ling, X. F. B. A comparative analysis of HGSC and Celera human genome assemblies and gene sets Bioinformatics 2003 19:1597-1605 DOI:10.1093/bioinformatics/btg219 PMID:12967954
- Anderson, J. C., Schultz, P. G. Adaptation of an orthogonal archaeal leucyl-tRNA and synthetase pair for four-base, amber, and opal suppression Biochemistry 2003 42:9598-9608 DOI:10.1021/bi034550w PMID:12911301
- Chin, J. W., Cropp, T. A., Anderson, J. C., Mukherji, M., Zhang, Z. W., Schultz, P. G. An expanded eukaryotic genetic code Science 2003 301:964-967 DOI:10.1126/science.1084772 PMID:12920298
- Wu, T. Y. H., Wagner, K. W., Bursulaya, B., Schultz, P. G., Deveraux, Q. L. Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction Chemistry & Biology 2003 10:759-767 DOI:10.1016/s1074-5521(03)00157-1 PMID:12954335
- Yin, J., Beuscher, A. E., Andryski, S. E., Stevens, R. C., Schultz, P. G. Structural plasticity and the evolution of antibody affinity and specificity Journal of Molecular Biology 2003 330:651-656 DOI:10.1016/s0022-2836(03)00631-4 PMID:12850137
- Ding, S., Wu, T. Y. H., Brinker, A., Peters, E. C., Hur, W., Gray, N. S., Schultz, P. G. Synthetic small molecules that control stem cell fate Proceedings of the National Academy of Sciences of the United States of America 2003 100:7632-7637 DOI:10.1073/pnas.0732087100 PMID:12794184 PMCID:PMC164638
- Zhang, Z. W., Smith, B. A. C., Wang, L., Brock, A., Cho, C., Schultz, P. G. A new strategy for the site-specific modification of proteins in vivo Biochemistry 2003 42:6735-6746 DOI:10.1021/bi0300231 PMID:12779328
- Chin, J. W., Cropp, T. A., Chu, S., Meggers, E., Schultz, P. G. Progress toward an expanded eukaryotic genetic code Chemistry & Biology 2003 10:511-519 DOI:10.1016/s1074-5521(03)00123-6 PMID:12837384
- Matsuda, S., Henry, A. A., Schultz, P. G., Romesberg, F. E. The effect of minor-groove hydrogen-bond acceptors and donors on the stability and replication of four unnatural base pairs Journal of the American Chemical Society 2003 125:6134-6139 DOI:10.1021/ja034099w PMID:12785844
- Liao, J. Y., Schultz, P. G. Three sweet receptor genes are clustered in human chromosome 1 Mammalian Genome 2003 14:291-301 DOI:10.1007/s00335-002-2233-0 PMID:12856281
- Licht, S. S., Sonnleitner, A., Weiss, S., Schultz, P. G. A rugged energy landscape mechanism for trapping of transmembrane receptors during endocytosis Biochemistry 2003 42:2916-2925 DOI:10.1021/bi026059v PMID:12627957
- Liu, H. T., Wang, L., Brock, A., Wong, C. H., Schultz, P. G. A method for the generation of glycoprotein mimetics Journal of the American Chemical Society 2003 125:1702-1703 DOI:10.1021/ja029433n PMID:12580587
- Yin, J., Andryski, S. E., Beuscher, A. E., Stevens, R. C., Schultz, P. G. Structural evidence for substrate strain in antibody catalysis Proceedings of the National Academy of Sciences of the United States of America 2003 100:856-861 DOI:10.1073/pnas.0235873100 PMID:12552112 PMCID:PMC298691
- Mehl, R. A., Anderson, J. C., Santoro, S. W., Wang, L., Martin, A. B., King, D. S., Horn, D. M., Schultz, P. G. Generation of a bacterium with a 21 amino acid genetic code Journal of the American Chemical Society 2003 125:935-939 DOI:10.1021/ja0284153 PMID:12537491
- Lin, Q., Barbas, C. F., Schultz, P. G. Small-molecule switches for zinc finger transcription factors Journal of the American Chemical Society 2003 125:612-613 DOI:10.1021/ja0248408e PMID:12526643
- Salomon, A. R., Ficarro, S. B., Brill, L. M., Brinker, A., Phung, Q. T., Ericson, C., Sauer, K., Brock, A., Horn, D. M., Schultz, P. G., Peters, E. C. Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry Proceedings of the National Academy of Sciences of the United States of America 2003 100:443-448 DOI:10.1073/pnas.2436191100 PMID:12522270 PMCID:PMC141014
- Wang, L., Xie, J. M., Deniz, A. A., Schultz, P. G. Unnatural amino acid mutagenesis of green fluorescent protein Journal of Organic Chemistry 2003 68:174-176 DOI:10.1021/jo026570u PMID:12515477
- Wang, L., Zhang, Z. W., Brock, A., Schultz, P. G. Addition of the keto functional group to the genetic code of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America 2003 100:56-61 DOI:10.1073/pnas.0234824100 PMID:12518054 PMCID:PMC140882
- Gildersleeve, J., Varvak, A., Atwell, S., Evans, D., Schultz, P. G. Development of a high-throughput screen for protein catalysts: application to the directed evolution of antibody aldolases Angewandte Chemie-International Edition 2003 42:5971-5973 DOI:10.1002/anie.200352117 PMID:14679545
- Santoro, S. W., Schultz, P. G. Directed evolution of the substrate specificities of a site-specific recombinase and an aminoacyl-tRNA synthetase using fluorescence-activated cell sorting (FACS) Methods in Molecular Biology 2003 230:291-312 DOI:10.1385/1-59259-396-8:291 PMID:12824591
- Wieland, S. F., Vega, R. G., Muller, R., Evans, C. F., Hilbush, B., Guidotti, L. G., Sutcliffe, J. G., Schultz, P. G., Chisari, F. V. Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes Journal of Virology 2003 77:1227-1236 DOI:10.1128/jvi.77.2.1227-1236.2003 PMID:12502840 PMCID:PMC140855
- Chapman, E., Ding, S., Schultz, P. G., Wong, C. H. A potent and highly selective sulfotransferase inhibitor Journal of the American Chemical Society 2002 124:14524-14525 DOI:10.1021/ja021086u PMID:12465948
- Wu, X., Ding, S., Ding, Q., Gray, N. S., Schultz, P. G. A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells Journal of the American Chemical Society 2002 124:14520-14521 DOI:10.1021/ja0283908 PMID:12465946
- Wu, Y. Q., Fa, M., Tae, E. L., Schultz, P. G., Romesberg, F. E. Enzymatic phosphorylation of unnatural nucleosides Journal of the American Chemical Society 2002 124:14626-14630 DOI:10.1021/ja028050m PMID:12465973
- Su, A. I., Pezacki, J. P., Wodicka, L., Brideau, A. D., Supekova, L., Thimme, R., Wieland, S., Bukh, J., Purcell, R. H., Schultz, P. G., Chisari, F. V. Genomic analysis of the host response to hepatitis C virus infection Proceedings of the National Academy of Sciences of the United States of America 2002 99:15669-15674 DOI:10.1073/pnas.202608199 PMID:12441396 PMCID:PMC137774
- Zimmermann, N., Meggers, E., Schultz, P. G. A novel silver(I)-mediated DNA base pair Journal of the American Chemical Society 2002 124:13684-13685 DOI:10.1021/ja0279951 PMID:12431092
- Wu, T. Y. H., Schultz, P. G. A versatile linkage strategy for solid-phase synthesis of N,N-dimethyltryptamines and β-carbolines Organic Letters 2002 4:4033-4036 DOI:10.1021/ol026729p PMID:12423079
- Chin, J. W., Schultz, P. G. In vivo photocrosslinking with unnatural amino acid mutagenesis ChemBioChem 2002 3:1135-1137 DOI:10.1002/1439-7633(20021104)3:11<1135::aid-cbic1135>3.0.co;2-m PMID:12404640
- Santoro, S. W., Wang, L., Herberich, B., King, D. S., Schultz, P. G. An efficient system for the evolution of aminoacyl-tRNA synthetase specificity Nature Biotechnology 2002 20:1044-1048 DOI:10.1038/nbt742 PMID:12244330
- Knockaert, M., Lenormand, P., Gray, N., Schultz, P., Pouyssegur, J., Meijer, L. P42/p44 MAPKs are intracellular targets of the CDK inhibitor purvalanol Oncogene 2002 21:6413-6424 DOI:10.1038/sj.onc.1205908 PMID:12226745
- Lesley, S. A., Kuhn, P., Godzik, A., Deacon, A. M., Mathews, I., Kreusch, A., Spraggon, G., Klock, H. E., McMullan, D., Shin, T., Vincent, J., Robb, A., et al. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline Proceedings of the National Academy of Sciences of the United States of America 2002 99:11664-11669 DOI:10.1073/pnas.142413399 PMID:12193646 PMCID:PMC129326
- Chang, Y. T., Choi, G., Bae, Y. S., Burdett, M., Moon, H. S., Lee, J. W., Gray, N. S., Schultz, P. G., Meijer, L., Chung, S. K., Choi, K. Y., Suh, P. G., et al. Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase ChemBioChem 2002 3:897-901 DOI:10.1002/1439-7633(20020902)3:9<897::aid-cbic897>3.0.co;2-b PMID:12210991
- Chin, J. W., Martin, A. B., King, D. S., Wang, L., Schultz, P. G. Addition of a photocrosslinking amino acid to the genetic code of Escherichia coli Proceedings of the National Academy of Sciences of the United States of America 2002 99:11020-11024 DOI:10.1073/pnas.172226299 PMID:12154230 PMCID:PMC123203
- Su, A. I., Guidotti, L. G., Pezacki, J. P., Chisari, F. V., Schultz, P. G. Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice Proceedings of the National Academy of Sciences of the United States of America 2002 99:11181-11186 DOI:10.1073/pnas.122359899 PMID:12177410 PMCID:PMC123230
- Winssinger, N., Ficarro, S., Schultz, P. G., Harris, J. L. Profiling protein function with small molecule microarrays Proceedings of the National Academy of Sciences of the United States of America 2002 99:11139-11144 DOI:10.1073/pnas.172286899 PMID:12167675 PMCID:PMC123223
- Chin, J. W., Santoro, S. W., Martin, A. B., King, D. S., Wang, L., Schultz, P. G. Addition of p-azido-L-phenylaianine to the genetic code of Escherichia coli Journal of the American Chemical Society 2002 124:9026-9027 DOI:10.1021/ja027007w PMID:12148987
- Schultz, P. G., Lerner, R. A. Antibody catalysis: completing the circle Nature 2002 418:485-485 DOI:10.1038/418485a PMID:12152057
- Li, S. Y., Liao, J. Y., Cutler, G., Hoey, T., Hogenesch, J. B., Cooke, M. P., Schultz, P. G., Ling, X. F. B. Comparative analysis of human genome assemblies reveals genome-level differences Genomics 2002 80:138-139 DOI:10.1006/geno.2002.6824 PMID:12160725
- Supekova, L., Pezacki, J. P., Su, A. I., Loweth, C. J., Riedl, R., Geierstanger, B., Schultz, P. G., Wemmer, D. E. Genomic effects of polyamide/DNA interactions on mRNA expression Chemistry & Biology 2002 9:821-827 DOI:10.1016/s1074-5521(02)00174-6 PMID:12144926
- Damoiseaux, R., Schultz, P. G., Johnsson, K. Towards the generation of artificial O(6)-alkylguanine-DNA alkyltransferases: in vitro selection of antibodies with reactive cysteine residues ChemBioChem 2002 3:573-575 DOI:10.1002/1439-7633(20020603)3:6<573::aid-cbic573>3.0.co;2-f PMID:12325014
- Xia, G., Chen, L. J., Sera, T., Fa, M., Schultz, P. G., Romesberg, F. E. Directed evolution of novel polymerase activities: mutation of a DNA polymerase into an efficient RNA polymerase Proceedings of the National Academy of Sciences of the United States of America 2002 99:6597-6602 DOI:10.1073/pnas.102577799 PMID:12011423 PMCID:PMC124448
- Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. B., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., Hogenesch, J. B. Coordinated transcription of key pathways in the mouse by the circadian clock Cell 2002 109:307-320 DOI:10.1016/s0092-8674(02)00722-5 PMID:12015981
- Santoro, S. W., Schultz, P. G. Directed evolution of the site specificity of Cre recombinase Proceedings of the National Academy of Sciences of the United States of America 2002 99:4185-4190 DOI:10.1073/pnas.022039799 PMID:11904359 PMCID:PMC123623
- Su, A. I., Cooke, M. P., Ching, K. A., Hakak, Y., Walker, J. R., Wiltshire, T., Orth, A. P., Vega, R. G., Sapinoso, L. M., Moqrich, A., Patapoutian, A., Hampton, G. M., et al. Large-scale analysis of the human and mouse transcriptomes Proceedings of the National Academy of Sciences of the United States of America 2002 99:4465-4470 DOI:10.1073/pnas.012025199 PMID:11904358 PMCID:PMC123671
- Santarsiero, B. D., Yegian, D. T., Lee, C. C., Spraggon, G., Gu, J., Scheibe, D., Uber, D. C., Cornell, E. W., Nordmeyer, R. A., Kolbe, W. F., Jin, J., Jones, A. L., et al. An approach to rapid protein crystallization using nanodroplets Journal of Applied Crystallography 2002 35:278-281 DOI:10.1107/s0021889802001474
- Perez, O. D., Chang, Y. T., Rosania, G., Sutherlin, D., Schultz, P. G. Inhibition and reversal of myogenic differentiation by purine-based microtubule assembly inhibitors Chemistry & Biology 2002 9:475-483 DOI:10.1016/s1074-5521(02)00131-x PMID:11983336
- Wang, L., Brock, A., Schultz, P. G. Adding L-3-(2-naphthyl)alanine to the genetic code of E. coli Journal of the American Chemical Society 2002 124:1836-1837 DOI:10.1021/ja012307j PMID:11866580
- Chang, Y. T., Choi, J., Ding, S., Prieschl, E. E., Baumruker, T., Lee, J. M., Chung, S. K., Schultz, P. G. The synthesis and biological characterization of a ceramide library Journal of the American Chemical Society 2002 124:1856-1857 DOI:10.1021/ja017576o PMID:11866590
- Ding, S., Gray, N. S., Ding, Q., Wu, X., Schultz, P. G. Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines Journal of Combinatorial Chemistry 2002 4:183-186 DOI:10.1021/cc010080i PMID:11886295
- Ding, S., Gray, N. S., Wu, X., Ding, Q., Schultz, P. G. A combinatorial scaffold approach toward kinase-directed heterocycle libraries Journal of the American Chemical Society 2002 124:1594-1596 DOI:10.1021/ja0170302 PMID:11853431
- Anderson, J. C., Magliery, T. J., Schultz, P. G. Exploring the limits of codon and anticodon size Chemistry & Biology 2002 9:237-244 DOI:10.1016/s1074-5521(02)00094-7 PMID:11880038
- Watanabe, C. M. H., Supekova, L., Schultz, P. G. Transcriptional effects of the potent enediyne anti-cancer agent calicheamicin gamma Chemistry & Biology 2002 9:245-251 DOI:10.1016/s1074-5521(02)00103-5 PMID:11880039
- Gildersleeve, J., Janes, J., Ulrich, H., Yang, P., Barbas, C., Schultz, P. G. Development of a genetic selection for catalytic antibodies Bioorganic & Medicinal Chemistry Letters 2002 12:1691-1694 DOI:10.1016/s0960-894x(02)00198-1 PMID:12039592
- Wang, L., Schultz, P. G. Expanding the genetic code Chemical Communications 2002 1-11 DOI:10.1039/b108185n
- Block-Alper, L., Webster, P., Zhou, X. H., Supekova, L., Wong, W. H., Schultz, P. G., Meyer, D. I. In02, a positive regulator of lipid biosynthesis, is essential for the formation of inducible membranes in yeast Molecular Biology of the Cell 2002 13:40-51 DOI:10.1091/mbc.01-07-0366 PMID:11809821 PMCID:PMC65071
- Yu, C. Z., Henry, A. A., Romesberg, F. E., Schultz, P. G. Polymerase recognition of unnatural base pairs Angewandte Chemie-International Edition 2002 41:3841-3844 DOI:10.1002/1521-3773(20021018)41:20<3841::aid-anie3841>3.0.co;2-q PMID:12386865
- Schultz, P. G., Yin, J., Lerner, R. A. The chemistry of the antibody molecule Angewandte Chemie-International Edition 2002 41:4427-4437 DOI:10.1002/1521-3773(20021202)41:23<4427::aid-anie4427>3.0.co;2-k PMID:12458503
- Zhang, Z. W., Wang, L., Brock, A., Schultz, P. G. The selective incorporation of alkenes into proteins in Escherichia coli Angewandte Chemie-International Edition 2002 41:2840-2842 DOI:10.1002/1521-3773(20020802)41:15<2840::aid-anie2840>3.0.co;2-# PMID:12203503
- Chang, Y. T., Wignall, S. M., Rosania, G. R., Gray, N. S., Hanson, S. R., Su, A. I., Merlie, J., Moon, H. S., Sangankar, S. B., Perez, O., Heald, R., Schultz, P. G. Synthesis and biological evaluation of myoseverin derivatives: microtubule assembly inhibitors Journal of Medicinal Chemistry 2001 44:4497-4500 DOI:10.1021/jm010451+ PMID:11741468
- Atwell, S., Meggers, E., Spraggon, G., Schultz, P. G. Structure of a copper-mediated base pair in DNA Journal of the American Chemical Society 2001 123:12364-12367 DOI:10.1021/ja011822e PMID:11734038
- Ding, S., Gray, N. S., Ding, Q., Schultz, P. G. Expanding the diversity of purine libraries Tetrahedron Letters 2001 42:8751-8755 DOI:10.1016/s0040-4039(01)01925-6
- Ding, S., Gray, N. S., Ding, Q., Schultz, P. G. A concise and traceless linker strategy toward combinatorial libraries of 2,6,9-substituted purines Journal of Organic Chemistry 2001 66:8273-8276 DOI:10.1021/jo016010f PMID:11722241
- Wu, T. Y. H., Ding, S., Gray, N. S., Schultz, P. G. Solid-phase synthesis of 2,3,5-trisubstituted indoles Organic Letters 2001 3:3827-3830 DOI:10.1021/ol016525t PMID:11720546
- Lin, Q., Jiang, F. Y., Schultz, P. G., Gray, N. S. Design of allele-specific protein methyltransferase inhibitors Journal of the American Chemical Society 2001 123:11608-11613 DOI:10.1021/ja011423j PMID:11716715
- Su, A. I., Welsh, J. B., Sapinoso, L. M., Kern, S. G., Dimitrov, P., Lapp, H., Schultz, P. G., Powell, S. M., Moskaluk, C. A., Frierson, H. F., Hampton, G. M. Molecular classification of human carcinomas by use of gene expression signatures Cancer Research 2001 61:7388-7393 PMID:11606367
- Yin, J., Mundorff, E. C., Yang, P. L., Wendt, K. U., Hanway, D., Stevens, R. C., Schultz, P. G. A comparative analysis of the immunological evolution of antibody 28B4 Biochemistry 2001 40:10764-10773 DOI:10.1021/bi010536c PMID:11535051
- Spence, M. M., Rubin, S. M., Dimitrov, I. E., Ruiz, E. J., Wemmer, D. E., Pines, A., Yao, S. Q., Tian, F., Schultz, P. G. Functionalized xenon as a biosensor Proceedings of the National Academy of Sciences of the United States of America 2001 98:10654-10657 DOI:10.1073/pnas.191368398 PMID:11535830 PMCID:PMC58521
- Wang, L., Schultz, P. G. A general approach for the generation of orthogonal tRNAs Chemistry & Biology 2001 8:883-890 DOI:10.1016/s1074-5521(01)00063-1 PMID:11564556
- Pastrnak, M., Schultz, P. G. Phage selection for site-specific incorporation of unnatural amino acids into proteins in vivo Bioorganic & Medicinal Chemistry 2001 9:2373-2379 DOI:10.1016/s0968-0896(01)00157-2 PMID:11553478
- Hogenesch, J. B., Ching, K. A., Batalov, S., Su, A. I., Walker, J. R., Zhou, Y., Kay, S. A., Schultz, P. G., Cooke, M. P. A comparison of the Celera and Ensembl predicted gene sets reveals little overlap in novel genes Cell 2001 106:413-415 DOI:10.1016/s0092-8674(01)00467-6 PMID:11534548
- Verdugo, D. E., Cancilla, M. T., Ge, X., Gray, N. S., Chang, Y. T., Schultz, P. G., Negishi, M., Leary, J. A., Bertozzi, C. R. Discovery of estrogen sulfotransferase inhibitors from a purine library screen Journal of Medicinal Chemistry 2001 44:2683-2686 DOI:10.1021/jm010171u PMID:11495578
- Tae, E. J. L., Wu, Y. Q., Xia, G., Schultz, P. G., Romesberg, F. E. Efforts toward expansion of the genetic alphabet: replication of DNA with three base pairs Journal of the American Chemical Society 2001 123:7439-7440 DOI:10.1021/ja010731e PMID:11472182
- Harmse, L., van Zyl, R., Gray, N., Schultz, P., Leclerc, S., Meijer, L., Doerig, C., Havlik, I. Structure-activity relationships and inhibitory effects of various purine derivatives on the in vitro growth of Plasmodium falciparum Biochemical Pharmacology 2001 62:341-348 DOI:10.1016/s0006-2952(01)00644-x PMID:11434907
- Mody, M., Cao, Y. X., Cui, Z. Z., Tay, K. Y., Shyong, A., Shimizu, E., Pham, K., Schultz, P., Welsh, D., Tsien, J. Z. Genome-wide gene expression profiles of the developing mouse hippocampus Proceedings of the National Academy of Sciences of the United States of America 2001 98:8862-8867 DOI:10.1073/pnas.141244998 PMID:11438693 PMCID:PMC37526
- Watanabe, C. M. H., Wolffram, S., Ader, P., Rimbach, G., Packer, L., Maguire, J. J., Schultz, P. G., Gohil, K. The in vivo neuromodulatory effects of the herbal medicine Ginkgo biloba Proceedings of the National Academy of Sciences of the United States of America 2001 98:6577-6580 DOI:10.1073/pnas.111126298 PMID:11381109 PMCID:PMC34395
- Grunwell, J. R., Glass, J. L., Lacoste, T. D., Deniz, A. A., Chemla, D. S., Schultz, P. G. Monitoring the conformational fluctuations of DNA hairpins using single-pair fluorescence resonance energy transfer Journal of the American Chemical Society 2001 123:4295-4303 DOI:10.1021/ja0027620 PMID:11457196
- Wang, L., Brock, A., Herberich, B., Schultz, P. G. Expanding the genetic code of Escherichia coli Science 2001 292:498-500 DOI:10.1126/science.1060077 PMID:11313494
- Magliery, T. J., Anderson, J. C., Schultz, P. G. Expanding the genetic code: selection of efficient suppressors of four-base codons and identification of "shifty" four-base codons with a library approach in Escherichia coli Journal of Molecular Biology 2001 307:755-769 DOI:10.1006/jmbi.2001.4518 PMID:11273699
- Lu, T., Ting, A. Y., Mainland, J., Jan, L. Y., Schultz, P. G., Yang, J. Probing ion permeation and gating in a K+ channel with backbone mutations in the selectivity filter Nature Neuroscience 2001 4:239-246 DOI:10.1038/85080 PMID:11224539
- Jiang, C. H., Tsien, J. Z., Schultz, P. G., Hu, Y. H. The effects of aging on gene expression in the hypothalamus and cortex of mice Proceedings of the National Academy of Sciences of the United States of America 2001 98:1930-1934 DOI:10.1073/pnas.98.4.1930 PMID:11172053 PMCID:PMC29359
- Winssinger, N., Harris, J. L., Backes, B. J., Schultz, P. G. From split-pool libraries to spatially addressable microarrays and its application to functional proteomic profiling Angewandte Chemie-International Edition 2001 40:3152-3155 DOI:10.1002/1521-3773(20010903)40:17<3152::aid-anie3152>3.0.co;2-p
- Ting, A. Y., Witte, K., Shah, K., Kraybill, B., Shokat, K. M., Schultz, P. G. Phage-display evolution of tyrosine kinases with altered nucleotide specificity Biopolymers 2001 60:220-228 DOI:10.1002/1097-0282(2001)60:3<220::aid-bip10035>3.0.co;2-c PMID:11774228
- Deniz, A. A., Laurence, T. A., Dahan, M., Chemla, D. S., Schultz, P. G., Weiss, S. Ratiometric single-molecule studies of freely diffusing biomolecules Annual Review of Physical Chemistry 2001 52:233-253 DOI:10.1146/annurev.physchem.52.1.233 PMID:11326065
- Rampon, C., Jiang, C. H., Dong, H., Tang, Y. P., Lockhart, D. J., Schultz, P. G., Tsien, J. Z., Hu, Y. H. Effects of environmental enrichment on gene expression in the brain Proceedings of the National Academy of Sciences of the United States of America 2000 97:12880-12884 DOI:10.1073/pnas.97.23.12880 PMID:11070096 PMCID:PMC18858
- Meggers, E., Holland, P. L., Tolman, W. B., Romesberg, F. E., Schultz, P. G. A novel copper-mediated DNA base pair Journal of the American Chemical Society 2000 122:10714-10715 DOI:10.1021/ja0025806
- Simeonov, A., Matsushita, M., Juban, E. A., Thompson, E. H. Z., Hoffman, T. Z., Beuscher, A. E., Taylor, M. J., Wirsching, P., Rettig, W., McCusker, J. K., Stevens, R. C., Millar, D. P., et al. Blue-fluorescent antibodies Science 2000 290:307-313 DOI:10.1126/science.290.5490.307 PMID:11030644
- Simbulan-Rosenthal, C. M., Ly, D. H., Rosenthal, D. S., Konopka, G., Luo, R. B., Wang, Z. Q., Schultz, P. G., Smulson, M. E. Misregulation of gene expression in primary fibroblasts lacking poly(ADP-ribose) polymerase Proceedings of the National Academy of Sciences of the United States of America 2000 97:11274-11279 DOI:10.1073/pnas.200285797 PMID:11016956 PMCID:PMC17190
- Bishop, A. C., Ubersax, J. A., Petsch, D. T., Matheos, D. P., Gray, N. S., Blethrow, J., Shimizu, E., Tsien, J. Z., Schultz, P. G., Rose, M. D., Wood, J. L., Morgan, D. O., et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase Nature 2000 407:395-401 PMID:11014197
- Ogawa, A. K., Wu, Y. Q., Berger, M., Schultz, P. G., Romesberg, F. E. Rational design of an unnatural base pair with increased kinetic selectivity Journal of the American Chemical Society 2000 122:8803-8804 DOI:10.1021/ja001450u
- Wu, Y. Q., Ogawa, A. K., Berger, M., McMinn, D. L., Schultz, P. G., Romesberg, F. E. Efforts toward expansion of the genetic alphabet: optimization of interbase hydrophobic interactions Journal of the American Chemical Society 2000 122:7621-7632 DOI:10.1021/ja0009931
- Berger, M., Wu, Y. Q., Ogawa, A. K., McMinn, D. L., Schultz, P. G., Romesberg, F. E. Universal bases for hybridization, replication and chain termination Nucleic Acids Research 2000 28:2911-2914 DOI:10.1093/nar/28.15.2911 PMID:10908353
- Guo, Z. H., Zhou, D. M., Schultz, P. G. Designing small-molecule switches for protein-protein interactions Science 2000 288:2042-2045 DOI:10.1126/science.288.5473.2042 PMID:10856217
- Knockaert, M., Gray, N., Damiens, E., Chang, Y. T., Grellier, P., Grant, K., Fergusson, D., Mottram, J., Soete, M., Dubremetz, J. F., Le Roch, K., Doerig, C., et al. Intracellular targets of cyclin-dependent kinase inhibitors: identification by affinity chromatography using immobilised inhibitors Chemistry & Biology 2000 7:411-422 DOI:10.1016/s1074-5521(00)00124-1 PMID:10873834
- Wang, L., Magliery, T. J., Liu, D. R., Schultz, P. G. A new functional suppressor tRNA/aminoacyl-tRNA synthetase pair for the in vivo incorporation of unnatural amino acids into proteins Journal of the American Chemical Society 2000 122:5010-5011 DOI:10.1021/ja000595y
- Deniz, A. A., Laurence, T. A., Beligere, G. S., Dahan, M., Martin, A. B., Chemla, D. S., Dawson, P. E., Schultz, P. G., Weiss, S. Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2 Proceedings of the National Academy of Sciences of the United States of America 2000 97:5179-5184 DOI:10.1073/pnas.090104997 PMID:10792044 PMCID:PMC25802
- Ogawa, A. K., Wu, Y. Q., McMinn, D. L., Liu, J. Q., Schultz, P. G., Romesberg, F. E. Efforts toward the expansion of the genetic alphabet: information storage and replication with unnatural hydrophobic base pairs Journal of the American Chemical Society 2000 122:3274-3287 DOI:10.1021/ja9940064
- Ly, D. H., Lockhart, D. J., Lerner, R. A., Schultz, P. G. Mitotic misregulation and human aging Science 2000 287:2486-2492 DOI:10.1126/science.287.5462.2486 PMID:10741968
- Rosania, G. R., Chang, Y. T., Perez, O., Sutherlin, D., Dong, H. L., Lockhart, D. J., Schultz, P. G. Myoseverin, a microtubule-binding molecule with novel cellular effects Nature Biotechnology 2000 18:304-308 PMID:10700146
- Pastrnak, M., Magliery, T. J., Schultz, P. G. A new orthogonal suppressor tRNA/aminoacyl-tRNA synthetase pair for evolving an organism with an expanded genetic code Helvetica Chimica Acta 2000 83:2277-2286 DOI:10.1002/1522-2675(20000906)83:9<2277::aid-hlca2277>3.0.co;2-l
- Armstrong, J. I., Portley, A. R., Chang, Y. T., Nierengarten, D. M., Cook, B. N., Bowman, K. G., Bishop, A., Gray, N. S., Shokat, K. M., Schultz, P. G., Bertozzi, C. R. Discovery of carbohydrate sulfotransferase inhibitors from a kinase-directed library Angewandte Chemie-International Edition 2000 39:1303-1306 DOI:10.1002/(sici)1521-3773(20000403)39:7<1303::aid-anie1303>3.0.co;2-0 PMID:10767039
- Berger, M., Ogawa, A. K., McMinn, D. L., Wu, Y. Q., Schultz, P. G., Romesberg, F. E. Stable and selective hybridization of oligonucleotides with unnatural hydrophobic bases Angewandte Chemie-International Edition 2000 39:2940-2942 DOI:10.1002/1521-3773(20000818)39:16<2940::aid-anie2940>3.0.co;2-# PMID:11028017
- Yang, P. L., Schultz, P. G. Mutational analysis of the affinity maturation of antibody 48G7 Journal of Molecular Biology 1999 294:1191-1201 DOI:10.1006/jmbi.1999.3197 PMID:10600377
- McMinn, D. L., Ogawa, A. K., Wu, Y. Q., Liu, J. Q., Schultz, P. G., Romesberg, F. E. Efforts toward expansion of the genetic alphabet: DNA polymerase recognition of a highly stable, self-fairing hydrophobic base Journal of the American Chemical Society 1999 121:11585-11586 DOI:10.1021/ja9925150
- Martin, A. B., Schultz, P. G. Opportunities at the interface of chemistry and biology Trends in Biochemical Sciences 1999 24:M24-M28 DOI:10.1016/s0968-0004(99)01498-x
- Martin, A. B., Schultz, P. G. Opportunities at the interface of chemistry and biology (Reprinted from Trends in Biochemical Science, vol 12, Dec., 1999) Trends in Genetics 1999 15:M24-M28 DOI:10.1016/s0168-9525(99)01907-1
- Ma, L. F., Sweet, E. H., Schultz, P. G. Selective antibody-catalyzed solvolysis of endo-2-norbornyl mesylate Journal of the American Chemical Society 1999 121:10227-10228 DOI:10.1021/ja990896b
- Chang, Y. T., Schultz, P. G. Versatile fluorescence labeling method using activated esters on solid support Bioorganic & Medicinal Chemistry Letters 1999 9:2479-2482 DOI:10.1016/s0960-894x(99)00422-9 PMID:10498192
- Barrett, J. E., Lucero, C. M., Schultz, P. G. A model for hydride transfer in thymidylate synthase based on unnatural amino acid mutagenesis Journal of the American Chemical Society 1999 121:7965-7966 DOI:10.1021/ja991040+
- Dahan, M., Deniz, A. A., Ha, T. J., Chemla, D. S., Schultz, P. G., Weiss, S. Ratiometric measurement and identification of single diffusing molecules Chemical Physics 1999 247:85-106 DOI:10.1016/s0301-0104(99)00132-9
- Ha, T. J., Ting, A. Y., Liang, J., Deniz, A. A., Chemla, D. S., Schultz, P. G., Weiss, S. Temporal fluctuations of fluorescence resonance energy transfer between two dyes conjugated to a single protein Chemical Physics 1999 247:107-118 DOI:10.1016/s0301-0104(99)00149-4
- Romesberg, F. E., Schultz, P. G. A mutational study of a Diels-Alderase catalytic antibody Bioorganic & Medicinal Chemistry Letters 1999 9:1741-1744 DOI:10.1016/s0960-894x(99)00281-4 PMID:10406634
- Cho, C. Y., Liu, C. W., Wemmer, D. E., Schultz, P. G. Cyclic and linear oligocarbamate ligands for human thrombin Bioorganic & Medicinal Chemistry 1999 7:1171-1179 DOI:10.1016/s0968-0896(99)00028-0 PMID:10428389
- Chang, Y. T., Gray, N. S., Rosania, G. R., Sutherlin, D. P., Kwon, S., Norman, T. C., Sarohia, R., Leost, M., Meijer, L., Schultz, P. G. Synthesis and application of functionally diverse 2,6,9-trisubstituted purine libraries as CDK inhibitors Chemistry & Biology 1999 6:361-375 DOI:10.1016/s1074-5521(99)80048-9 PMID:10375538
- Yao, S., Anex, D. S., Caldwell, W. B., Arnold, D. W., Smith, K. B., Schultz, P. G. SDS capillary gel electrophoresis of proteins in microfabricated channels Proceedings of the National Academy of Sciences of the United States of America 1999 96:5372-5377 DOI:10.1073/pnas.96.10.5372 PMID:10318890 PMCID:PMC21866
- Rosania, G. R., Merlie, J., Gray, N., Chang, Y. T., Schultz, P. G., Heald, R. A cyclin-dependent kinase inhibitor inducing cancer cell differentiation: biochemical identification using Xenopus egg extracts Proceedings of the National Academy of Sciences of the United States of America 1999 96:4797-4802 DOI:10.1073/pnas.96.9.4797 PMID:10220373 PMCID:PMC21771
- Liu, D. R., Schultz, P. G. Progress toward the evolution of an organism with an expanded genetic code Proceedings of the National Academy of Sciences of the United States of America 1999 96:4780-4785 DOI:10.1073/pnas.96.9.4780 PMID:10220370
- Deniz, A. A., Dahan, M., Grunwell, J. R., Ha, T. J., Faulhaber, A. E., Chemla, D. S., Weiss, S., Schultz, P. G. Single-pair fluorescence resonance energy transfer on freely diffusing molecules: observation of Förster distance dependence and subpopulations Proceedings of the National Academy of Sciences of the United States of America 1999 96:3670-3675 DOI:10.1073/pnas.96.7.3670 PMID:10097095 PMCID:PMC22352
- Kanamori, T., Nishikawa, S., Nakai, M., Shin, I., Schultz, P. G., Endo, T. Uncoupling of transfer of the presequence and unfolding of the mature domain in precursor translocation across the mitochondrial outer membrane Proceedings of the National Academy of Sciences of the United States of America 1999 96:3634-3639 DOI:10.1073/pnas.96.7.3634 PMID:10097089
- Ha, T. J., Ting, A. Y., Liang, J., Caldwell, W. B., Deniz, A. A., Chemla, D. S., Schultz, P. G., Weiss, S. Single-molecule fluorescence spectroscopy of enzyme conformational dynamics and cleavage mechanism Proceedings of the National Academy of Sciences of the United States of America 1999 96:893-898 DOI:10.1073/pnas.96.3.893 PMID:9927664
- Liu, Y. Q., Barrett, J. E., Schultz, P. G., Santi, D. V. Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2 '-deoxyuridine 5 '-monophosphate Biochemistry 1999 38:848-852 DOI:10.1021/bi9822877 PMID:9888826
- Loweth, C. J., Caldwell, W. B., Peng, X. G., Alivisatos, A. P., Schultz, P. G. DNA-based assembly of gold nanocrystals Angewandte Chemie-International Edition 1999 38:1808-1812 DOI:10.1002/(sici)1521-3773(19990614)38:12<1808::aid-anie1808>3.3.co;2-3
- Liu, D. R., Schultz, P. G. Generating new molecular function: a lesson from nature Angewandte Chemie-International Edition 1999 38:36-54 DOI:10.1002/(sici)1521-3773(19990115)38:1/2<36::aid-anie36>3.0.co;2-i
- Schultz, P. G. Bringing biological solutions to chemical problems Proceedings of the National Academy of Sciences of the United States of America 1998 95:14590-14591 DOI:10.1073/pnas.95.25.14590 PMID:9843932 PMCID:PMC33924
- Romesberg, F. E., Santarsiero, B. D., Spiller, B., Yin, J., Barnes, D., Schultz, P. G., Stevens, R. C. Structural and kinetic evidence for strain in biological catalysis Biochemistry 1998 37:14404-14409 DOI:10.1021/bi981578c PMID:9772166
- Isaacs, E. D., Marcus, M., Aeppli, G., Xiang, X. D., Sun, X. D., Schultz, P., Kao, H. K., Cargill, G. S., Haushalter, R. Synchrotron X-ray microbeam diagnostics of combinatorial synthesis Applied Physics Letters 1998 73:1820-1822 DOI:10.1063/1.122293
- Pedersen, H., Holder, S., Sutherlin, D. P., Schwitter, U., King, D. S., Schultz, P. G. A method for directed evolution and functional cloning of enzymes Proceedings of the National Academy of Sciences of the United States of America 1998 95:10523-10528 DOI:10.1073/pnas.95.18.10523 PMID:9724736
- Pollitt, S. K., Schultz, P. G. A photochemical switch for controlling protein-protein interactions Angewandte Chemie-International Edition 1998 37:2104-2107 DOI:10.1002/(sici)1521-3773(19980817)37:15<2104::aid-anie2104>3.0.co;2-z
- Takeuchi, I., Chang, H., Gao, C., Schultz, P. G., Xiang, X. D., Sharma, R. P., Downes, M. J., Venkatesan, T. Combinatorial synthesis and evaluation of epitaxial ferroelectric device libraries Applied Physics Letters 1998 73:894-896 DOI:10.1063/1.122030
- Cho, C. Y., Youngquist, R. S., Paikoff, S. J., Beresini, M. H., Hebert, A. R., Berleau, L. T., Liu, C. W., Wemmer, D. E., Keough, T., Schultz, P. G. Synthesis and screening of linear and cyclic oligocarbamate libraries. Discovery of high affinity ligands for gpiib/iiia Journal of the American Chemical Society 1998 120:7706-7718 DOI:10.1021/ja9734399
- Driggers, E. M., Liu, C. W., Wemmer, D. E., Schultz, P. G. Structure of the michaelis complex of an efficient antibody acyl transferase determined by transferred nuclear overhauser enhancement spectroscopy Journal of the American Chemical Society 1998 120:7395-7396 DOI:10.1021/ja9813313
- Gray, N. S., Wodicka, L., Thunnissen, Amwh, Norman, T. C., Kwon, S. J., Espinoza, F. H., Morgan, D. O., Barnes, G., LeClerc, S., Meijer, L., Kim, S. H., Lockhart, D. J., et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors Science 1998 281:533-538 DOI:10.1126/science.281.5376.533 PMID:9677190
- Ting, A. Y., Shin, I., Lucero, C., Schultz, P. G. Energetic analysis of an engineered cation-Ï€ interaction in Staphylococcal nuclease Journal of the American Chemical Society 1998 120:7135-7136 DOI:10.1021/ja981520l
- Ma, L. F., Hsieh-Wilson, L. C., Schultz, P. G. Antibody catalysis of peptidyl-prolyl cis-trans isomerization in the folding of RNase T1 Proceedings of the National Academy of Sciences of the United States of America 1998 95:7251-7256 DOI:10.1073/pnas.95.13.7251 PMID:9636134
- Romesberg, F. E., Flanagan, M. E., Uno, T., Schultz, P. G. Mechanistic studies of an antibody-catalyzed elimination reaction Journal of the American Chemical Society 1998 120:5160-5167 DOI:10.1021/ja9738992
- Chang, H., Gao, C., Takeuchi, I., Yoo, Y., Wang, J., Schultz, P. G., Xiang, X. D., Sharma, R. P., Downes, M., Venkatesan, T. Combinatorial synthesis and high throughput evaluation of ferroelectric/dielectric thin-film libraries for microwave applications Applied Physics Letters 1998 72:2185-2187 DOI:10.1063/1.121316
- Schultz, P. G., Xiang, X. D. Combinatorial approaches to materials science Current Opinion in Solid State & Materials Science 1998 3:153-158 DOI:10.1016/s1359-0286(98)80081-8
- Romesberg, F. E., Spiller, B., Schultz, P. G., Stevens, R. C. Immunological origins of binding and catalysis in a Diels-Alderase antibody Science 1998 279:1929-1933 DOI:10.1126/science.279.5358.1929 PMID:9506942
- Yu, J., Choi, S. Y., Moon, K. D., Chung, H. H., Youn, H. J., Jeong, S., Park, H., Schultz, P. G. A glycosidase antibody elicited against a chair-like transition state analog by in vitro immunization Proceedings of the National Academy of Sciences of the United States of America 1998 95:2880-2884 DOI:10.1073/pnas.95.6.2880 PMID:9501184 PMCID:PMC19663
- Wang, J. S., Yoo, Y., Gao, C., Takeuchi, I., Sun, X. D., Chang, H. Y., Xiang, X. D., Schultz, P. G. Identification of a blue photoluminescent composite material from a combinatorial library Science 1998 279:1712-1714 DOI:10.1126/science.279.5357.1712 PMID:9497288
- Driggers, E. M., Cho, H. S., Liu, C. W., Katzka, C. P., Braisted, A. C., Ulrich, H. D., Wemmer, D. E., Schultz, P. G. Mechanistic studies of an antibody-catalyzed pericyclic rearrangement Journal of the American Chemical Society 1998 120:1945-1958 DOI:10.1021/ja962933u
- Thorson, J. S., Shin, I., Chapman, E., Stenberg, G., Mannervik, B., Schultz, P. G. Analysis of the role of the active site tyrosine in human glutathione transferase A1-1 by unnatural amino acid mutagenesis Journal of the American Chemical Society 1998 120:451-452 DOI:10.1021/ja9731682
- Barrett, J. E., Maltby, D. A., Santi, D. V., Schultz, P. G. Trapping of the C5 methylene intermediate in thymidylate synthase Journal of the American Chemical Society 1998 120:449-450 DOI:10.1021/ja973210t
- Blackwood, M. E., Rush, T. S., Romesberg, F., Schultz, P. G., Spiro, T. G. Alternative modes of substrate distortion in enzyme and antibody catalyzed ferrochelation reactions Biochemistry 1998 37:779-782 DOI:10.1021/bi972616f PMID:9457047
- Ulrich, H. D., Schultz, P. G. Analysis of hapten binding and catalytic determinants in a family of catalytic antibodies Journal of Molecular Biology 1998 275:95-111 DOI:10.1006/jmbi.1997.1445 PMID:9451442
- Thorson, J. S., Cornish, V. W., Barrett, J. E., Cload, S. T., Yano, T., Schultz, P. G. A biosynthetic approach for the incorporation of unnatural amino acids into proteins Methods in Molecular Biology 1998 77:43-73 DOI:10.1385/0-89603-397-x:43 PMID:9770661
- Shin, I. J., Ting, A. Y., Schultz, P. G. Analysis of backbone hydrogen bonding in a beta-turn of Staphylococcal nuclease Journal of the American Chemical Society 1997 119:12667-12668 DOI:10.1021/ja972820q
- Ulrich, H. D., Moore, F. L., Schultz, P. G. Germline diversity within the mouse igk-v9 gene family Immunogenetics 1997 47:91-95 DOI:10.1007/s002510050331 PMID:9382926
- Brooks, E. E., Gray, N. S., Joly, A., Kerwar, S. S., Lum, R., Mackman, R. L., Norman, T. C., Rosete, J., Rowe, M., Schow, S. R., Schultz, P. G., Wang, X. B., et al. CVT-313, a specific and potent inhibitor of CDK2 that prevents neointimal proliferation Journal of Biological Chemistry 1997 272:29207-29211 DOI:10.1074/jbc.272.46.29207 PMID:9360999
- Hall, D. G., Schultz, P. G. Synthesis of diverse ethoxyformacetal oligomers. Toward libraries of metal-coordinating unnatural biopolymers Tetrahedron Letters 1997 38:7825-7828 DOI:10.1016/s0040-4039(97)10094-6
- Sun, X. D., Wang, K. A., Yoo, Y., Wallace-Freedman, W. G., Gao, C., Xiang, X. D., Schultz, P. G. Solution-phase synthesis of luminescent materials libraries Advanced Materials 1997 9:1046-1049 DOI:10.1002/adma.19970091311
- Yu, J., Choi, S. Y., Lee, S., Yoon, H. J., Jeong, S., Mun, H., Park, H., Schultz, P. G. Antibody-catalysed glycosyl transfer reactions from in vitro immunization Chemical Communications 1997 1957-1958 DOI:10.1039/a704885h
- Koh, J. T., Cornish, V. W., Schultz, P. G. An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis Biochemistry 1997 36:11314-11322 DOI:10.1021/bi9707685 PMID:9298950
- Ulrich, H. D., Mundroff, E., Santarsiero, B. D., Driggers, E. M., Stevens, R. C., Schultz, P. G. The interplay between binding energy and catalysis in the evolution of a catalytic antibody Nature 1997 389:271-275 PMID:9305839
- Liu, D. R., Magliery, T. J., Pasternak, M., Schultz, P. G. Engineering a tRNA and aminoacyl-tRNA synthetase for the site-specific incorporation of unnatural amino acids into proteins in vivo Proceedings of the National Academy of Sciences of the United States of America 1997 94:10092-10097 DOI:10.1073/pnas.94.19.10092 PMID:9294168
- Liu, D. R., Magliery, T. J., Schultz, P. G. Characterization of an 'orthogonal' suppressor tRNA derived from E. coli tRNA2(Gln) Chemistry & Biology 1997 4:685-691 DOI:10.1016/s1074-5521(97)90224-6 PMID:9331409
- Park, Y. W., Luo, J. K., Schultz, P. G., Kirsch, J. F. Noncoded amino acid replacement probes of the aspartate aminotransferase mechanism Biochemistry 1997 36:10517-10525 DOI:10.1021/bi970298e PMID:9265632
- Xiang, X. D., Schultz, P. G. The combinatorial synthesis and evaluation of functional materials Physica C 1997 282:428-430 DOI:10.1016/s0921-4534(97)00297-9
- Chapman, E., Thorson, J. S., Schultz, P. G. Mutational analysis of backbone hydrogen bonds in Staphylococcal nuclease Journal of the American Chemical Society 1997 119:7151-7152 DOI:10.1021/ja970826+
- Lu, Y. L., Wei, T., Duewer, F., Lu, Y. Q., Ming, N. B., Schultz, P. G., Xiang, X. D. Nondestructive imaging of dielectric-constant profiles and ferroelectric domains with a scanning-tip microwave near-field microscope Science 1997 276:2004-2006 DOI:10.1126/science.276.5321.2004
- Wedemayer, G. J., Wang, L. H., Patten, P. A., Schultz, P. G., Stevens, R. C. Crystal structures of the free and liganded form of an esterolytic catalytic antibody Journal of Molecular Biology 1997 268:390-400 DOI:10.1006/jmbi.1997.0974 PMID:9159478
- Gray, N. S., Kwon, S., Schultz, P. G. Combinatorial synthesis of 2,9-substituted purines Tetrahedron Letters 1997 38:1161-1164 DOI:10.1016/s0040-4039(97)00014-2
- Johnsson, K., Froland, W. A., Schultz, P. G. Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis Journal of Biological Chemistry 1997 272:2834-2840 PMID:9006925
- Kanamori, T., Nishikawa, S. I., Shin, I., Schultz, P. G., Endo, T. Probing the environment along the protein import pathways in yeast mitochondria by site-specific photocrosslinking Proceedings of the National Academy of Sciences of the United States of America 1997 94:485-490 DOI:10.1073/pnas.94.2.485 PMID:9012810
- Wedemayer, G. J., Patten, P. A., Wang, L. H., Schultz, P. G., Stevens, R. C. Structural insights into the evolution of an antibody combining site Science 1997 276:1665-1669 DOI:10.1126/science.276.5319.1665 PMID:9180069
- Peng, X. G., Wilson, T. E., Alivisatos, A. P., Schultz, P. G. Synthesis and isolation of a homodimer of cadmium selenide nanocrystals Angewandte Chemie-International Edition 1997 36:145-147 DOI:10.1002/anie.199701451
- Cload, S. T., Liu, D. R., Froland, W. A., Schultz, P. G. Development of improved tRNAs for in vitro biosynthesis of proteins containing unnatural amino acids Chemistry & Biology 1996 3:1033-1038 DOI:10.1016/s1074-5521(96)90169-6 PMID:9000011
- Yoon, S. S., Oei, Y., Sweet, E., Schultz, P. G. An antibody-catalyzed 2,3-elimination reaction Journal of the American Chemical Society 1996 118:11686-11687 DOI:10.1021/ja962257w
- Bi, Y. Z., Schultz, P. G. Building blocks for peptide and carbamate libraries Bioorganic & Medicinal Chemistry Letters 1996 6:2299-2300 DOI:10.1016/0960-894x(96)00414-3
- Cornish, V. W., Hahn, K. M., Schultz, P. G. Site-specific protein modification using a ketone handle Journal of the American Chemical Society 1996 118:8150-8151 DOI:10.1021/ja961216x
- Alivisatos, A. P., Johnsson, K. P., Peng, X. G., Wilson, T. E., Loweth, C. J., Bruchez, M. P., Schultz, P. G. Organization of 'nanocrystal molecules' using DNA Nature 1996 382:609-611 DOI:10.1038/382609a0 PMID:8757130
- Norman, T. C., Gray, N. S., Koh, J. T., Schultz, P. G. A structure-based library approach to kinase inhibitors Journal of the American Chemical Society 1996 118:7430-7431 DOI:10.1021/ja9614934
- Paikoff, S. J., Wilson, T. E., Cho, C. Y., Schultz, P. G. The solid phase synthesis of N-alkylcarbamate oligomers Tetrahedron Letters 1996 37:5653-5656 DOI:10.1016/0040-4039(96)01197-5
- Conn, M. M., Prudent, J. R., Schultz, P. G. Porphyrin metalation catalyzed by a small RNA molecule Journal of the American Chemical Society 1996 118:7012-7013 DOI:10.1021/ja961249c
- Kim, J. M., Wilson, T. E., Norman, T. C., Schultz, P. G. Synthesis of a cyclic urea as a nonnatural biopolymer scaffold Tetrahedron Letters 1996 37:5309-5312 DOI:10.1016/0040-4039(96)01101-x
- Kim, J. M., Bi, Y. Z., Paikoff, S. J., Schultz, P. G. The solid phase synthesis of oligoureas Tetrahedron Letters 1996 37:5305-5308 DOI:10.1016/0040-4039(96)01100-8
- Flanagan, M. E., Jacobsen, J. R., Sweet, E., Schultz, P. G. Antibody-catalyzed retro-aldol reaction Journal of the American Chemical Society 1996 118:6078-6079 DOI:10.1021/ja954221u
- Fan, E., Oei, Y., Sweet, E., Uno, T., Schultz, P. G. Antibodies with thiol-S-transferase activity Journal of the American Chemical Society 1996 118:5474-5475 DOI:10.1021/ja9602105
- Wei, T., Xiang, X. D., WallaceFreedman, W. G., Schultz, P. G. Scanning tip microwave near-field microscope Applied Physics Letters 1996 68:3506-3508 DOI:10.1063/1.115773
- HsiehWilson, L. C., Schultz, P. G., Stevens, R. C. Insights into antibody catalysis: structure of an oxygenation catalyst at 1.9 Ã… resolution Proceedings of the National Academy of Sciences of the United States of America 1996 93:5363-5367 DOI:10.1073/pnas.93.11.5363 PMID:8643580
- Uno, T., Ku, J., Prudent, J. R., Huang, A., Schultz, P. G. An antibody-catalyzed isomerization reaction Journal of the American Chemical Society 1996 118:3811-3817 DOI:10.1021/ja9542449
- Sera, T., Schultz, P. G. In vivo selection of basic region-leucine zipper proteins with altered DNA-binding specificities Proceedings of the National Academy of Sciences of the United States of America 1996 93:2920-2925 DOI:10.1073/pnas.93.7.2920 PMID:8610143
- Ulrich, H. D., Driggers, E. M. G., Schultz, P. G. Antibody catalysis of pericyclic reactions Acta Chemica Scandinavica 1996 50:328-332 DOI:10.3891/acta.chem.scand.50-0328 PMID:8639375
- Patten, P. A., Gray, N. S., Yang, P. L., Marks, C. B., Wedemayer, G. J., Boniface, J. J., Stevens, R. C., Schultz, P. G. The immunological evolution of catalysis Science 1996 271:1086-1091 DOI:10.1126/science.271.5252.1086 PMID:8599084
- Liu, D. R., Cload, S. T., Pastor, R. M., Schultz, P. G. Analysis of active site residues in Escherichia coli chorismate mutase by site-directed mutagenesis Journal of the American Chemical Society 1996 118:1789-1790 DOI:10.1021/ja953151o
- Cload, S. T., Liu, D. R., Pastor, R. M., Schultz, P. G. Mutagenesis study of active site residues in chorismate mutase from Bacillus subtilis Journal of the American Chemical Society 1996 118:1787-1788 DOI:10.1021/ja953152g
- Driggers, E. M., Schultz, P. G. Catalytic antibodies Antigen Binding Molecules: Antibodies and T-Cell Receptors 1996 49:261-287 DOI:10.1016/s0065-3233(08)60491-x PMID:8908300
- Hsieh-Wilson, L. C., Xiang, X. D., Schultz, P. G. Lessons from the immune system: from catalysis to materials science Accounts of Chemical Research 1996 29:164-170 DOI:10.1021/ar950247e
- Stevens, R. C., HsiehWilson, L. C., Santarsiero, B. D., Wedemayer, G. J., Spiller, B., Wang, L. H., Barnes, D., Ulrich, H. D., Patten, P. A., Romesberg, F. E., Schultz, P. G. Structural studies of catalytic antibodies Israel Journal of Chemistry 1996 36:121-132
- Ulrich, H. D., Patten, P. A., Yang, P. L., Romesberg, F. E., Schultz, P. G. Expression studies of catalytic antibodies Proceedings of the National Academy of Sciences of the United States of America 1995 92:11907-11911 DOI:10.1073/pnas.92.25.11907 PMID:8524873
- Jacobsen, J. R., Schultz, P. G. The scope of antibody catalysis Current Opinion in Structural Biology 1995 5:818-824 DOI:10.1016/0959-440x(95)80016-6 PMID:8749371
- Briceno, G., Chang, H. Y., Sun, X. D., Schultz, P. G., Xiang, X. D. A class of cobalt oxide magnetoresistance materials discovered with combinatorial synthesis Science 1995 270:273-275 DOI:10.1126/science.270.5234.273
- Prudent, J. R., Staunton, J., Schultz, P. G. Probing the structural determinants of a catalytic RNA with isomerase activity Journal of the American Chemical Society 1995 117:10145-10146 DOI:10.1021/ja00145a039
- Schultz, P. G., Lerner, R. A. From molecular diversity to catalysis: lessons from the immune system Science 1995 269:1835-1842 DOI:10.1126/science.7569920 PMID:7569920
- Thorson, J. S., Chapman, E., Schultz, P. G. Analysis of hydrogen bonding strengths in proteins using unnatural amino acids Journal of the American Chemical Society 1995 117:9361-9362 DOI:10.1021/ja00141a032
- Cook, S. N., Jack, W. E., Xiong, X. F., Danley, L. E., Ellman, J. A., Schultz, P. G., Noren, C. J. Photochemically initiated protein splicing Angewandte Chemie-International Edition 1995 34:1629-1630 DOI:10.1002/anie.199516291
- Ku, J., Schultz, P. G. Alternate protein frameworks for molecular recognition Proceedings of the National Academy of Sciences of the United States of America 1995 92:6552-6556 DOI:10.1073/pnas.92.14.6552 PMID:7604031
- Xiang, X. D., Sun, X. D., Briceno, G., Lou, Y. L., Wang, K. A., Chang, H. Y., Wallacefreedman, W. G., Chen, S. W., Schultz, P. G. A combinatorial approach to materials discovery Science 1995 268:1738-1740 DOI:10.1126/science.268.5218.1738 PMID:17834993
- Jacobsen, J. R., Cochran, A. G., Stephans, J. C., King, D. S., Schultz, P. G. Mechanistic studies of antibody-catalyzed pyrimidine dimer photocleavage Journal of the American Chemical Society 1995 117:5453-5461 DOI:10.1021/ja00125a004
- Johnsson, K., King, D. S., Schultz, P. G. Studies on the mechanism of action of isoniazid and ethionamide in the chemotherapy of tuberculosis Journal of the American Chemical Society 1995 117:5009-5010 DOI:10.1021/ja00122a038
- Nowak, M. W., Kearney, P. C., Sampson, J. R., Saks, M. E., Labarca, C. G., Silverman, S. K., Zhong, W., Thorson, J. S., Abelson, J. N., Davidson, N., Schultz, P. G., Dougherty, D. A., et al. Nicotinic receptor binding site probed with unnatural amino acid incorporation in intact cells Science 1995 268:439-442 DOI:10.1126/science.7716551 PMID:7716551
- Muller, W. T., Klein, D. L., Lee, T., Clarke, J., McEuen, P. L., Schultz, P. G. A strategy for the chemical synthesis of nanostructures Science 1995 268:272-273 DOI:10.1126/science.268.5208.272 PMID:17814791
- Thorson, J. S., Chapman, E., Murphy, E. C., Schultz, P. G., Judice, J. K. Linear free-energy analysis of hydrogen-bonding in proteins Journal of the American Chemical Society 1995 117:1157-1158 DOI:10.1021/ja00108a044
- Moran, E. J., Wilson, T. E., Cho, C. Y., Cherry, S. R., Schultz, P. G. Novel biopolymers for drug discovery Biopolymers 1995 37:213-219 DOI:10.1002/bip.360370305 PMID:7718743
- Cornish, V. W., Mendel, D., Schultz, P. G. Probing protein structure and function with an expanded genetic code Angewandte Chemie-International Edition 1995 34:621-633 DOI:10.1002/anie.199506211
- Mendel, D., Cornish, V. W., Schultz, P. G. Site-directed mutagenesis with an expanded genetic code Annual Review of Biophysics and Biomolecular Structure 1995 24:435-462 DOI:10.1146/annurev.biophys.24.1.435 PMID:7663123
- Cornish, V. W., Kaplan, M. I., Veenstra, D. L., Kollman, P. A., Schultz, P. G. Stabilizing and destabilizing effects of placing beta-branched amino-acids in protein alpha-helices Biochemistry 1994 33:12022-12031 DOI:10.1021/bi00206a003 PMID:7918421
- Johnsson, K., Schultz, P. G. Mechanistic studies of the oxidation of isoniazid by the catalase peroxidase from Mycobacterium tuberculosis Journal of the American Chemical Society 1994 116:7425-7426 DOI:10.1021/ja00095a063
- Cornish, V. W., Schultz, P. G. A new tool for studying protein-structure and function Current Opinion in Structural Biology 1994 4:601-607 DOI:10.1016/s0959-440x(94)90224-0
- Prudent, J. R., Uno, T., Schultz, P. G. Expanding the scope of RNA catalysis Science 1994 264:1924-1927 PMID:8009223
- Jacobsen, J. R., Schultz, P. G. Antibody catalysis of peptide-bond formation Proceedings of the National Academy of Sciences of the United States of America 1994 91:5888-5892 DOI:10.1073/pnas.91.13.5888 PMID:8016084
- Vanvranken, D. L., Panomitros, D., Schultz, P. G. Catalysis of carbamate hydrolysis by an antibody Tetrahedron Letters 1994 35:3873-3876 DOI:10.1016/s0040-4039(00)76689-5
- Huang, L. X., Sera, T., Schultz, P. G. A permutational approach toward protein-DNA recognition Proceedings of the National Academy of Sciences of the United States of America 1994 91:3969-3973 DOI:10.1073/pnas.91.9.3969 PMID:8171021
- Cornish, V. W., Benson, D. R., Altenbach, C. A., Hideg, K., Hubbell, W. L., Schultz, P. G. Site-specific incorporation of biophysical probes into proteins Proceedings of the National Academy of Sciences of the United States of America 1994 91:2910-2914 DOI:10.1073/pnas.91.8.2910 PMID:8159678
- Shokat, K., Uno, T., Schultz, P. G. Mechanistic studies of an antibody-catalyzed elimination reaction Journal of the American Chemical Society 1994 116:2261-2270 DOI:10.1021/ja00085a004
- Braisted, A. C., Schultz, P. G. An antibody-catalyzed oxy-Cope rearrangement Journal of the American Chemical Society 1994 116:2211-2212 DOI:10.1021/ja00084a098
- Hsieh, L. C., Stephans, J. C., Schultz, P. G. An efficient antibody-catalyzed oxygenation reaction Journal of the American Chemical Society 1994 116:2167-2168 DOI:10.1021/ja00084a076
- Campbell, D. A., Gong, B., Kochersperger, L. M., Yonkovich, S., Gallop, M. A., Schultz, P. G. Antibody-catalyzed prodrug activation Journal of the American Chemical Society 1994 116:2165-2166 DOI:10.1021/ja00084a075
- Uno, T., Gong, B., Schultz, P. G. Stereoselective antibody-catalyzed oxime formation Journal of the American Chemical Society 1994 116:1145-1146 DOI:10.1021/ja00082a052
- Ku, J., Schultz, P. G. Phage display of catalytically active Staphylococcal nuclease Bioorganic & Medicinal Chemistry 1994 2:1413-1415 DOI:10.1016/S0968-0896(00)82093-3 PMID:7788304
- Chung, H., Schultz, P. G. Probing Ras function with unnatural amino acids Chemistry & Biology 1994 1:vi-vii DOI:10.1016/1074-5521(94)90020-5
- Yu, J. H., Hsieh, L. C., Kochersperger, L., Yonkovich, S., Stephans, J. C., Gallop, M. A., Schultz, P. G. Progress toward an antibody glycosidase Angewandte Chemie-International Edition 1994 33:339-341 DOI:10.1002/anie.199403391
- Angeles, T. S., Smith, R. G., Darsley, M. J., Sugasawara, R., Sanchez, R. I., Kenten, J., Schultz, P. G., Martin, M. T. Isoabzymes: structurally and mechanistically similar catalytic antibodies from the same immunization Biochemistry 1993 32:12128-12135 DOI:10.1021/bi00096a025 PMID:8218291
- Chung, H. H., Benson, D. R., Cornish, V. W., Schultz, P. G. Probing the role of loop 2 in Ras function with unnatural amino acids Proceedings of the National Academy of Sciences of the United States of America 1993 90:10145-10149 DOI:10.1073/pnas.90.21.10145 PMID:8234268 PMCID:PMC47730
- Judice, J. K., Gamble, T. R., Murphy, E. C., Devos, A. M., Schultz, P. G. Probing the mechanism of Staphylococcal nuclease with unnatural amino-acids: kinetic and structural studies Science 1993 261:1578-1581 DOI:10.1126/science.8103944 PMID:8103944
- Cho, C. Y., Moran, E. J., Cherry, S. R., Stephans, J. C., Fodor, S. P. A., Adams, C. L., Sundaram, A., Jacobs, J. W., Schultz, P. G. An unnatural biopolymer Science 1993 261:1303-1305 DOI:10.1126/science.7689747 PMID:7689747
- Schultz, P. G., Lerner, R. A. Antibody catalysis of difficult chemical transformations Accounts of Chemical Research 1993 26:391-395 DOI:10.1021/ar00032a001
- Chung, H. H., Benson, D. R., Schultz, P. G. Probing the role of lysine 16 in Ras p(21) protein with unnatural amino acids Journal of the American Chemical Society 1993 115:6414-6415 DOI:10.1021/ja00067a068
- Mendel, D., Ellman, J., Schultz, P. G. Protein biosynthesis with conformationally restricted amino acids Journal of the American Chemical Society 1993 115:4359-4360 DOI:10.1021/ja00063a063
- Sarvetnick, N., Gurushanthaiah, D., Han, N. H., Prudent, J., Schultz, P., Lerner, R. Increasing the chemical potential of the germ-line antibody repertoire Proceedings of the National Academy of Sciences of the United States of America 1993 90:4008-4011 DOI:10.1073/pnas.90.9.4008 PMID:8483917 PMCID:PMC46435
- Hsieh, L. C., Yonkovich, S., Kochersperger, L., Schultz, P. G. Controlling chemical reactivity with antibodies Science 1993 260:337-339 DOI:10.1126/science.10049109 PMID:10049109
- Lesley, S. A., Patten, P. A., Schultz, P. G. A genetic approach to the generation of antibodies with enhanced catalytic activities Proceedings of the National Academy of Sciences of the United States of America 1993 90:1160-1165 DOI:10.1073/pnas.90.4.1160 PMID:8094556
- Chung, H. H., Benson, D. R., Schultz, P. G. Probing the structure and mechanism of Ras protein with an expanded genetic code Science 1993 259:806-809 DOI:10.1126/science.8430333 PMID:8430333
- Skerker, P. S., Jacobs, J. W., Clark, D. S., Schultz, P. G. Probing a catalytic antibody active site using spin-labeled haptens Bioorganic & Medicinal Chemistry Letters 1993 3:285-288 DOI:10.1016/s0960-894x(01)80894-5
- Ellman, J. A., Volkman, B. F., Mendel, D., Schultz, P. G., Wemmer, D. E. Site-specific isotopic labeling of proteins for NMR studies Journal of the American Chemical Society 1992 114:7959-7961 DOI:10.1021/ja00046a080
- Uno, T., Schultz, P. G. An antibody-catalyzed dehydration reaction Journal of the American Chemical Society 1992 114:6573-6574 DOI:10.1021/ja00042a055
- Mendel, D., Ellman, J. A., Chang, Z. Y., Veenstra, D. L., Kollman, P. A., Schultz, P. G. Probing protein stability with unnatural amino acids Science 1992 256:1798-1802 DOI:10.1126/science.1615324 PMID:1615324
- Oldenburg, K. R., Loganathan, D., Goldstein, I. J., Schultz, P. G., Gallop, M. A. Peptide ligands for a sugar-binding protein isolated from a random peptide library Proceedings of the National Academy of Sciences of the United States of America 1992 89:5393-5397 DOI:10.1073/pnas.89.12.5393 PMID:1608948
- Jacobsen, J. R., Prudent, J. R., Kochersperger, L., Yonkovich, S., Schultz, P. G. An efficient antibody-catalyzed aminoacylation reaction Science 1992 256:365-367 DOI:10.1126/science.256.5055.365 PMID:1566082
- Gong, B., Lesley, S. A., Schultz, P. G. A chromogenic assay for screening large antibody libraries Journal of the American Chemical Society 1992 114:1486-1487 DOI:10.1021/ja00030a056
- Nakayama, G. R., Schultz, P. G. Stereospecific antibody-catalyzed reduction of an alpha-keto amide Journal of the American Chemical Society 1992 114:780-781 DOI:10.1021/ja00028a066
- Ellman, J. A., Mendel, D., Schultz, P. G. Site-specific incorporation of novel backbone structures into proteins Science 1992 255:197-200 DOI:10.1126/science.1553546 PMID:1553546
- Jackson, D. Y., Liang, M. N., Bartlett, P. A., Schultz, P. G. Activation parameters and stereochemistry of an antibody-catalyzed claisen rearrangement Angewandte Chemie-International Edition 1992 31:182-183 DOI:10.1002/anie.199201821
- Rozsnyai, L. F., Benson, D. R., Fodor, S. P. A., Schultz, P. G. Photolithographic immobilization of biopolymers on solid supports Angewandte Chemie-International Edition 1992 31:759-761 DOI:10.1002/anie.199207591
- Scanlan, T. S., Prudent, J. R., Schultz, P. G. Antibody-catalyzed hydrolysis of phosphate monoesters Journal of the American Chemical Society 1991 113:9397-9398 DOI:10.1021/ja00024a071
- Pei, D., Schultz, P. G. Engineering protein specificity: gene manipulation with semisynthetic nucleases Journal of the American Chemical Society 1991 113:9398-9400 DOI:10.1021/ja00024a072
- Jackson, D. Y., King, D. S., Chmielewski, J., Singh, S., Schultz, P. G. General-approach to the synthesis of short alpha-helical peptides Journal of the American Chemical Society 1991 113:9391-9392 DOI:10.1021/ja00024a067
- Martin, M. T., Napper, A. D., Schultz, P. G., Rees, A. R. Mechanistic studies of a tyrosine-dependent catalytic antibody Biochemistry 1991 30:9757-9761 DOI:10.1021/bi00104a027 PMID:1911763
- Pei, D., Ulrich, H. D., Schultz, P. G. A combinatorial approach toward DNA recognition Science 1991 253:1408-1411 DOI:10.1126/science.1716784 PMID:1716784
- Cochran, A. G., Pham, T., Sugasawara, R., Schultz, P. G. Antibody-catalyzed bimolecular imine formation Journal of the American Chemical Society 1991 113:6670-6672 DOI:10.1021/ja00017a046
- Scanlon, T. S., Schultz, P. G. Recent advances in catalytic antibodies Philosophical Transactions of the Royal Society of London Series B-Biological Sciences 1991 332:157-164 DOI:10.1098/rstb.1991.0044 PMID:1678534
- Lerner, R. A., Benkovic, S. J., Schultz, P. G. At the crossroads of chemistry and immunology: catalytic antibodies Science 1991 252:659-667 DOI:10.1126/science.2024118 PMID:2024118
- Chmielewski, J., Schultz, P. Monoclonal antibodies with sequence specific affinity for a stem-loop structure in DNA Tetrahedron 1991 47:2563-2572 DOI:10.1016/s0040-4020(01)81789-0
- Robertson, S. A., Ellman, J. A., Schultz, P. G. A general and efficient route for chemical aminoacylation of transfer RNAs Journal of the American Chemical Society 1991 113:2722-2729 DOI:10.1021/ja00007a055
- Mendel, D., Ellman, J. A., Schultz, P. G. Construction of a light-activated protein by unnatural amino acid mutagenesis Journal of the American Chemical Society 1991 113:2758-2760 DOI:10.1021/ja00007a063
- Jackson, D. Y., Schultz, P. G. An antibody-catalyzed cis trans isomerization reaction Journal of the American Chemical Society 1991 113:2319-2321 DOI:10.1021/ja00006a070
- Shokat, K. M., Schultz, P. G. Redirecting the immune response: ligand-mediated immunogenicity Journal of the American Chemical Society 1991 113:1861-1862 DOI:10.1021/ja00005a077
- Jackson, D. Y., Prudent, J. R., Baldwin, E. P., Schultz, P. G. A mutagenesis study of a catalytic antibody Proceedings of the National Academy of Sciences of the United States of America 1991 88:58-62 DOI:10.1073/pnas.88.1.58 PMID:1898778
- Nakayama, G. R., Schultz, P. G. Approaches to the design of semisynthetic metal-dependent catalytic antibodies Ciba Foundation Symposia 1991 159:72-90 PMID:1959454
- Ellman, J., Mendel, D., Anthony-Cahill, S., Noren, C. J., Schultz, P. G. Biosynthetic method for introducing unnatural amino acids site-specifically into proteins Methods in Enzymology 1991 202:301-336 DOI:10.1016/0076-6879(91)02017-4 PMID:1784180
- Shokat, K. M., Schultz, P. G. Catalytic antibodies Methods in Enzymology 1991 203:327-351 DOI:10.1016/0076-6879(91)03019-d PMID:1762563
- Martin, M. T., Schantz, A. R., Schultz, P. G., Rees, A. R. Characterization of the mechanism of action of a catalytic antibody Ciba Foundation Symposia 1991 159:188-200 PMID:1959447
- Shokat, K. M., Schultz, P. G. The generation of antibody combining sites containing catalytic residues Ciba Foundation Symposia 1991 159:118-144 PMID:1959444
- Cochran, A. G., Schultz, P. G. Peroxidase activity of an antibody heme complex Journal of the American Chemical Society 1990 112:9414-9415 DOI:10.1021/ja00181a065
- Pei, D. H., Corey, D. R., Schultz, P. G. Site-specific cleavage of duplex DNA by a semisynthetic nuclease via triple-helix formation Proceedings of the National Academy of Sciences of the United States of America 1990 87:9858-9862 DOI:10.1073/pnas.87.24.9858 PMID:2124705 PMCID:PMC55273
- Braisted, A. C., Schultz, P. G. An antibody-catalyzed bimolecular Diels-Alder reaction Journal of the American Chemical Society 1990 112:7430-7431 DOI:10.1021/ja00176a073
- Cochran, A. G., Schultz, P. G. Antibody-catalyzed porphyrin metalation Science 1990 249:781-783 DOI:10.1126/science.2389144 PMID:2389144
- Schultz, P. G., Lerner, R. A., Benkovic, S. J. Catalytic antibodies Chemical & Engineering News 1990 68:26-40 DOI:10.1021/cen-v068n022.p026
- Pei, D., Schultz, P. G. Site-specific cleavage of duplex DNA with a lambda-repressor Staphylococcal nuclease hybrid Journal of the American Chemical Society 1990 112:4579-4580 DOI:10.1021/ja00167a085
- Hoyer, D., Cho, H., Schultz, P. G. A new strategy for selective protein cleavage Journal of the American Chemical Society 1990 112:3249-3250 DOI:10.1021/ja00164a076
- Noren, C. J., Anthony-Cahill, S. J., Suich, D. J., Noren, K. A., Griffith, M. C., Schultz, P. G. In vitro suppression of an amber mutation by a chemically aminoacylated transfer RNA prepared by runoff transcription Nucleic Acids Research 1990 18:83-88 DOI:10.1093/nar/18.1.83 PMID:2308838 PMCID:PMC330206
- Shokat, K. M., Schultz, P. G. Catalytic antibodies Annual Review of Immunology 1990 8:335-363 DOI:10.1146/annurev.immunol.8.1.335 PMID:2188666
- Shokat, K. M., Ko, M. K., Scanlan, T. S., Kochersperger, L., Yonkovich, S., Thaisrivongs, S., Schultz, P. G. Catalytic antibodies: a new class of transition-state analogues used to elicit hydrolytic antibodies Angewandte Chemie-International Edition 1990 29:1296-1303 DOI:10.1002/anie.199012961
- Robertson, S. A., Noren, C. J., Anthony-Cahill, S. J., Griffith, M. C., Schultz, P. G. The use of 5'-phospho-2 deoxyribocytidylylriboadenosine as a facile route to chemical aminoacylation of transfer-RNA Nucleic Acids Research 1989 17:9649-9660 DOI:10.1093/nar/17.23.9649 PMID:2602139
- Corey, D. R., Pei, D., Schultz, P. G. Sequence-selective hydrolysis of duplex DNA by an oligonucleotide-directed nuclease Journal of the American Chemical Society 1989 111:8523-8525 DOI:10.1021/ja00204a038
- Corey, D. R., Pei, D., Schultz, P. G. Generation of a catalytic sequence-specific hybrid DNase Biochemistry 1989 28:8277-8286 DOI:10.1021/bi00447a004 PMID:2605184
- Schultz, P. G. Catalytic antibodies Angewandte Chemie-International Edition 1989 28:1283-1295 DOI:10.1002/anie.198912833
- Baldwin, E., Schultz, P. G. Generation of a catalytic antibody by site-directed mutagenesis Science 1989 245:1104-1107 DOI:10.1126/science.2672338 PMID:2672338
- Schultz, P. G. Catalytic antibodies Accounts of Chemical Research 1989 22:287-294 DOI:10.1021/ar00164a005
- Pollack, S. J., Hsiun, P., Schultz, P. G. Stereospecific hydrolysis of alkyl esters by antibodies Journal of the American Chemical Society 1989 111:5961-5962 DOI:10.1021/ja00197a078
- Saha, A. K., Schultz, P., Rapoport, H. 1,1'-carbonylbis(3-methylimidazolium) triflate: an efficient reagent for aminoacylations Journal of the American Chemical Society 1989 111:4856-4859 DOI:10.1021/ja00195a043
- Noren, C. J., Anthony-Cahill, S. J., Griffith, M. C., Schultz, P. G. A general method for site-specific incorporation of unnatural amino acids into proteins Science 1989 244:182-188 DOI:10.1126/science.2649980 PMID:2649980
- Shokat, K. M., Leumann, C. J., Sugasawara, R., Schultz, P. G. A new strategy for the generation of catalytic antibodies Nature 1989 338:269-271 DOI:10.1038/338269a0 PMID:2922053
- Corey, D. R., Schultz, P. G. Introduction of a metal-dependent regulatory switch into an enzyme Journal of Biological Chemistry 1989 264:3666-3669 PMID:2917969
- Pollack, S. J., Schultz, P. G. A semisynthetic catalytic antibody Journal of the American Chemical Society 1989 111:1929-1931 DOI:10.1021/ja00187a085
- Zuckermann, R. N., Schultz, P. G. Site-selective cleavage of structured RNA by a Staphylococcal nuclease DNA hybrid Proceedings of the National Academy of Sciences of the United States of America 1989 86:1766-1770 DOI:10.1073/pnas.86.6.1766 PMID:2467291
- Pollack, S. J., Nakayama, G. R., Schultz, P. G. Design of catalytic antibodies Methods in Enzymology 1989 178:551-568 PMID:2601630
- Anthony-Cahill, S. J., Griffith, M. C., Noren, C. J., Suich, D. J., Schultz, P. G. Site-specific mutagenesis with unnatural amino acids Trends in Biochemical Sciences 1989 14:400-403 DOI:10.1016/0968-0004(89)90287-9 PMID:2683258
- Durfor, C. N., Bolin, R. J., Sugasawara, R. J., Massey, R. J., Jacobs, J. W., Schultz, P. G. Antibody catalysis in reverse micelles Journal of the American Chemical Society 1988 110:8713-8714 DOI:10.1021/ja00234a032
- Pollack, S. J., Nakayama, G. R., Schultz, P. G. Introduction of nucleophiles and spectroscopic probes into antibody combining sites Science 1988 242:1038-1040 DOI:10.1126/science.3194752 PMID:3194752
- Cochran, A. G., Sugasawara, R., Schultz, P. G. Photosensitized cleavage of a thymine dimer by an antibody Journal of the American Chemical Society 1988 110:7888-7890 DOI:10.1021/ja00231a056
- Zuckermann, R. N., Schultz, P. G. A hybrid sequence-selective ribonuclease S Journal of the American Chemical Society 1988 110:6592-6594 DOI:10.1021/ja00227a066
- Jackson, D. Y., Jacobs, J. W., Sugasawara, R., Reich, S. H., Bartlett, P. A., Schultz, P. G. An antibody-catalyzed Claisen rearrangement Journal of the American Chemical Society 1988 110:4841-4842 DOI:10.1021/ja00222a060
- Schultz, P. G. The interplay between chemistry and biology in the design of enzymatic catalysts Science 1988 240:426-433 DOI:10.1126/science.2833815 PMID:2833815
- Zuckermann, R. N., Corey, D. R., Schultz, P. G. Site-selective cleavage of RNA by a hybrid enzyme Journal of the American Chemical Society 1988 110:1614-1615 DOI:10.1021/ja00213a040
- Shokat, K. M., Leumann, C. J., Sugasawara, R., Schultz, P. G. An antibody-mediated redox reaction Angewandte Chemie-International Edition 1988 27:1172-1174 DOI:10.1002/anie.198811721
- Corey, D. R., Schultz, P. G. Generation of a hybrid sequence-specific single-stranded deoxyribonuclease Science 1987 238:1401-1403 DOI:10.1126/science.3685986 PMID:3685986
- Zuckermann, R., Corey, D., Schultz, P. Efficient methods for attachment of thiol specific probes to the 3'-ends of synthetic oligodeoxyribonucleotides Nucleic Acids Research 1987 15:5305-5321 DOI:10.1093/nar/15.13.5305 PMID:3601673
- Jacobs, J., Schultz, P. G., Sugasawara, R., Powell, M. Catalytic antibodies Journal of the American Chemical Society 1987 109:2174-2176 DOI:10.1021/ja00241a042
- Pollack, S. J., Schultz, P. G. Antibody catalysis by transition-state stabilization Cold Spring Harbor Symposia on Quantitative Biology 1987 52:97-104 DOI:10.1101/SQB.1987.052.01.014 PMID:3454301
- Pollack, S. J., Jacobs, J. W., Schultz, P. G. Selective chemical catalysis by an antibody Science 1986 234:1570-1573 DOI:10.1126/science.3787262 PMID:3787262
- Schultz, P. G., Au, K. G., Walsh, C. T. Directed mutagenesis of the redox-active disulfide in the flavoenzyme mercuric ion reductase Biochemistry 1985 24:6840-6848 DOI:10.1021/bi00345a016 PMID:3907703
- Taylor, J. S., Schultz, P. G., Dervan, P. B. DNA affinity cleaving : sequence specific cleavage of DNA by distamycin-EDTA - Fe(II) and EDTA-distamycin Fe(II) Tetrahedron 1984 40:457-465 DOI:10.1016/0040-4020(84)85050-4
- Schultz, P. G., Dervan, P. B. Distamycin and penta-N-methylpyrrolecarboxamide binding sites on native DNA. A comparison of methidiumpropyl-EDTA-Fe(II) footprinting and DNA affinity cleaving Journal of Biomolecular Structure & Dynamics 1984 1:1133-1147 DOI:10.1080/07391102.1984.10507508 PMID:6101078
- Schultz, P. G., Dervan, P. B. Sequence-specific double-strand cleavage of DNA by bis(EDTA-distamycin.Fe(II) ) and EDTA-bis(distamycin).Fe(II) Journal of the American Chemical Society 1983 105:7748-7750 DOI:10.1021/ja00364a049
- Schultz, P. G., Dervan, P. B. Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA.Fe(II) Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 1983 80:6834-6837 DOI:10.1073/pnas.80.22.6834 PMID:6417654
- Schultz, P. G., Taylor, J. S., Dervan, P. B. Design and synthesis of a sequence-specific DNA cleaving molecule. (Distamycin-EDTA)iron(II) Journal of the American Chemical Society 1982 104:6861-6863 DOI:10.1021/ja00388a101
- Hinsberg, W. D., Schultz, P. G., Dervan, P. B. Direct studies of 1,1-diazenes. Syntheses, infrared and electronic spectra, and kinetics of the thermal decomposition of N-(2,2,6,6-tetramethylpiperidyl)nitrene and N-(2,2,5,5-tetramethylpyrrolidyl)nitrene Journal of the American Chemical Society 1982 104:766-773 DOI:10.1021/ja00367a020
- Schultz, P. G., Dervan, P. B. Photochemistry of 1,1-diazenes. Direct and sensitized photolyses of N-(2,2,5,5-tetramethylpyrrolidyl)nitrene, dl-N-(2,5-diethyl-2,5-dimethylpyrrolidyl)nitrene, and N-(2,2,6,6-tetramethylpiperidyl)nitrene Journal of the American Chemical Society 1982 104:6660-6668 DOI:10.1021/ja00388a031
- Schultz, P. G., Dervan, P. B. Photochemistry of a 1,1-diazene, N-(2,2,5,5-tetramethylpyrrolidinyl)nitrene Journal of the American Chemical Society 1981 103:1563-1564 DOI:10.1021/ja00396a048
- Schultz, P. G., Dervan, P. B. Synthesis and direct spectroscopic observation of N-(2,2,5,5-tetramethylpyrrolidyl)nitrene: comparison of 5-membered and 6-membered cyclic 1,1-dialkyldiazenes Journal of the American Chemical Society 1980 102:878-880 DOI:10.1021/ja00522a090