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Schneemann, Anette
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Schneemann, Anette

Faculty Member Adjunct
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Positions

  • 2017 - Associate Professor Adjunct, Molecular Medicine , Scripps Research
  • 1995 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2013 - 2016 Associate Professor, Cell and Molecular Biology (CMB) , Scripps Research
  • 2001 - 2012 Associate Professor, Molecular Biology , Scripps Research
  • 1995 - 2001 Assistant Professor, Molecular Biology , Scripps Research
Dr. Anette Schneemann focuses on the mechanisms of icosahedral viral capsid assembly and RNA packaging as well as the development of viral capsids as nanomaterials.

Contact

  • aschneem@scripps.edu

Websites

  • Anette Schneemann, Ph.D.
  • Laboratory Website
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Publications

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  • academic article

    • Short, J. R., Speir, J. A., Gopal, R., Pankratz, L. M., Lanman, J., Schneemann, A. Role of Mitochondrial Membrane Spherules in Flock House Virus Replication Journal of Virology  2016 90:3676-3683  DOI:10.1128/jvi.03080-15  PMID:26792749  PMCID:PMC4794695
    • Sung, J. J., Pardeshi, N. N., Mulder, A. M., Mulligan, S. K., Quispe, J., On, K., Carragher, B., Potter, C. S., Carpenter, J. F., Schneemann, A. Transmission electron microscopy as an orthogonal method to characterize protein aggregates Journal of Pharmaceutical Sciences  2015 104:750-759  DOI:10.1002/jps.24157  PMID:25231267  PMCID:PMC4376473
    • Gopal, R., Venter, P. A., Schneemann, A. Differential segregation of nodaviral coat protein and RNA into progeny virions during mixed infection with FHV and NoV Virology  2014 454:280-290  DOI:10.1016/j.virol.2014.03.003  PMID:24725955  PMCID:PMC4048152
    • Petrillo, J. E., Venter, P. A., Short, J. R., Gopal, R., Deddouche, S., Lamiable, O., Imler, J. L., Schneemann, A. Cytoplasmic granule formation and translational inhibition of nodaviral RNAs in the absence of the double-stranded RNA binding protein B2 Journal of Virology  2013 87:13409-13421  DOI:10.1128/jvi.02362-13  PMID:24089564  PMCID:PMC3838216
    • Liu, B., Behura, S. K., Clem, R. J., Schneemann, A., Becnel, J., Severson, D. W., Zhou, L. P53-mediated rapid induction of apoptosis conveys resistance to viral infection in drosophila melanogaster PLoS Pathogens  2013 9:e1003137  DOI:10.1371/journal.ppat.1003137  PMID:23408884  PMCID:PMC3567152
    • Xiong, X. P., Kurthkoti, K., Chang, K. Y., Lichinchi, G., De, N., Schneemann, A., Macrae, I. J., Rana, T. M., Perrimon, N., Zhou, R. Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila Proceedings of the National Academy of Sciences of the United States of America  2013 110:16520-16525  DOI:10.1073/pnas.1315803110  PMID:24067655  PMCID:PMC3799365
    • Schneemann, A., Speir, J. A., Tan, G. S., Khayat, R., Ekiert, D. C., Matsuoka, Y., Wilsona, I. A. A virus-like particle that elicits cross-reactive antibodies to the conserved stem of influenza virus hemagglutinin Journal of Virology  2012 86:11686-11697  DOI:10.1128/jvi.01694-12  PMID:22896619  PMCID:PMC3486276
    • Thomson, T. C., Schneemann, A., Johnson, J. Oocyte destruction is activated during viral infection Genesis  2012 50:453-465  DOI:10.1002/dvg.22004  PMID:22173880
    • Jovel, J., Schneemann, A. Molecular characterization of drosophila cells persistently infected with flock house virus Virology  2011 419:43-53  DOI:10.1016/j.virol.2011.08.002  PMID:21872290  PMCID:PMC3175792
    • Venter, P. A., Dirksen, A., Thomas, D., Manchester, M., Dawson, P. E., Schneemann, A. Multivalent display of proteins on viral nanoparticles using molecular recognition and chemical ligation strategies Biomacromolecules  2011 12:2293-2301  DOI:10.1021/bm200369e  PMID:21545187  PMCID:PMC3114102
    • Khayat, R., Brunn, N., Speir, J. A., Hardham, J. M., Ankenbauer, R. G., Schneemann, A., Johnson, J. E. The 2.3 Å structure of porcine circovirus 2 Journal of Virology  2011 85:7856-7862  DOI:10.1128/jvi.00737-11  PMID:21632760  PMCID:PMC3147897
    • Odegard, A. L., Kwan, M. H., Walukiewicz, H. E., Banerjee, M., Schneemann, A., Johnson, J. E. Low endocytic ph and capsid protein autocleavage are critical components of flock house virus cell entry Journal of Virology  2009 83:8628-8637  DOI:10.1128/jvi.00873-09  PMID:19553341  PMCID:PMC2738175
    • Banerjee, M., Khayat, R., Walukiewicz, H. E., Odegard, A. L., Schneemann, A., Johnson, J. E. Dissecting the functional domains of a nonenveloped virus membrane penetration peptide Journal of Virology  2009 83:6929-6933  DOI:10.1128/jvi.02299-08  PMID:19369344  PMCID:PMC2698515
    • Devkota, B., Petrov, A. S., Lemieux, S., Boz, M. B., Tang, L., Schneemann, A., Johnson, J. E., Harvey, S. C. Structural and electrostatic characterization of pariacoto virus: Implications for viral assembly Biopolymers  2009 91:530-538  DOI:10.1002/bip.21168  PMID:19226622  PMCID:PMC2720792
    • Kumar, S., Ochoa, W., Singh, P., Hsu, C., Schneemann, A., Manchester, M., Olson, M., Reddy, V. Tomato bushy stunt virus (TBSV), a versatile platform for polyvalent display of antigenic epitopes and vaccine design Virology  2009 388:185-190  DOI:10.1016/j.virol.2009.02.051  PMID:19344926
    • Venter, P. A., Marshall, D., Schneemann, A. Dual roles for an arginine-rich motif in specific genome recognition and localization of viral coat protein to rna replication sites in flock house virus-infected cells Journal of Virology  2009 83:2872-2882  DOI:10.1128/jvi.01780-08  PMID:19158251  PMCID:PMC2655541
    • Schneemann, A., Manchester, M. Anti-toxin antibodies in prophylaxis and treatment of inhalation anthrax Future Microbiology  2009 4:35-43  DOI:10.2217/17460913.4.1.35  PMID:19207098  PMCID:PMC2710805
    • Destito, G., Schneemann, A., Manchester, M. Biomedical nanotechnology using virus-based nanoparticles Current Topics in Microbiology and Immunology  2009 327:95-122  DOI:10.1007/978-3-540-69379-6_5  PMID:19198572
    • Venter, P. A., Schneemann, A. Recent insights into the biology and biomedical applications of flock house virus Cellular and Molecular Life Sciences  2008 65:2675-2687  DOI:10.1007/s00018-008-8037-y  PMID:18516498  PMCID:PMC2536769
    • Lanman, J., Crum, J., Deerinck, T. J., Gaietta, G. M., Schneemann, A., Sosinsky, G. E., Ellisman, M. H., Johnson, J. E. Visualizing flock house virus infection in drosophila cells with correlated fluorescence and electron microscopy Journal of Structural Biology  2008 161:439-446  DOI:10.1016/j.jsb.2007.09.009  PMID:17998167  PMCID:PMC2408891
    • Walukiewicz, H. E., Banerjee, M., Schneemann, A., Johnson, J. E. Rescue of maturation-defective flock house virus infectivity with noninfectious, mature, viruslike particles Journal of Virology  2008 82:2025-2027  DOI:10.1128/jvi.02278-07  PMID:18077727  PMCID:PMC2258709
    • Manayani, D. J., Thomas, D., Dryden, K. A., Reddy, V., Siladi, M. E., Marlett, J. M., Rainey, G. J. A., Pique, M. E., Scobie, H. M., Yeager, M., Young, J. A. T., Manchester, M., et al. A viral nanoparticle with dual function as an anthrax antitoxin and vaccine PLoS Pathogens  2007 3:1422-1431  DOI:10.1371/journal.ppat.0030142  PMID:17922572  PMCID:PMC2000967
    • Venter, P. A., Schneemann, A. Assembly of two independent populations of flock house virus particles with distinct rna packaging characteristics in the same cell Journal of Virology  2007 81:613-619  DOI:10.1128/jvi.01668-06  PMID:17079301
    • Thiery, R., Cozien, J., Cabon, J., Lamour, F., Baud, M., Schneemann, A. Induction of a protective immune response against viral nervous necrosis in the european sea bass dicentrarchus labrax by using betanodavirus virus-like particles Journal of Virology  2006 80:10201-10207  DOI:10.1128/jvi.01098-06  PMID:17005697
    • Maia, L. F., Soares, M. R., Valente, A. P., Almeida, F. C. L., Oliveira, A. C., Gomes, A. M. O., Freitas, M. S., Schneemann, A., Johnson, J. E., Silva, J. L. Structure of a membrane-binding domain from a non-enveloped animal virus - insights into the mechanism of membrane permeability and cellular entry Journal of Biological Chemistry  2006 281:29278-29286  DOI:10.1074/jbc.M604689200  PMID:16861222
    • Go, E. P., Wikoff, W. R., Shen, Z. X., O'Maille, G., Morita, H., Conrads, T. P., Nordstrom, A., Trauger, S. A., Uritboonthai, W., Lucas, D. A., Chan, K. C., Veenstra, T. D., et al. Mass spectrometry reveals specific and global molecular transformations during viral infection Journal of Proteome Research  2006 5:2405-2416  DOI:10.1021/pr060215t  PMID:16944953  PMCID:PMC2566936
    • Galiana-Arnoux, D., Dostert, C., Schneemann, A., Hoffmann, J. A., Imler, J. L. Essential function in vivo for dicer-2 in host defense against rna viruses in drosophila Nature Immunology  2006 7:590-597  DOI:10.1038/ni1335  PMID:16554838
    • Hsu, C., Singh, P., Ochoa, W., Manayani, D. J., Manchester, M., Schneemann, A., Reddy, V. S. Characterization of polymorphism displayed by the coat protein mutants of tomato bushy stunt virus Virology  2006 349:222-229  DOI:10.1016/j.virol.2006.02.038  PMID:16603216
    • Walukiewicz, H. E., Johnson, J. E., Schneemann, A. Morphological changes in the T=3 capsid of Flock House virus during cell entry Journal of Virology  2006 80:615-622  DOI:10.1128/jvi.80.2.615-622.2006  PMID:16378964  PMCID:PMC1346855
    • Chao, J. A., Lee, J. H., Chapados, B. R., Debler, E. W., Schneemann, A., Williamson, J. R. Dual modes of RNA-silencing suppression by Flock House virus protein B2 Nature Structural & Molecular Biology  2005 12:952-957  DOI:10.1038/nsmb1005  PMID:16228003
    • Venter, P. A., Krishna, N. K., Schneemann, A. Capsid protein synthesis from replicating rna directs specific packaging of the genome of a multipartite, positive-strand rna virus Journal of Virology  2005 79:6239-6248  DOI:10.1128/jvi.79.10.6239-6248.2005  PMID:15858008
    • Portney, N. G., Singh, K., Chaudhary, S., Destito, G., Schneemann, A., Manchester, M., Ozkan, M. Organic and inorganic nanoparticle hybrids Langmuir  2005 21:2098-2103  DOI:10.1021/la047525f  PMID:15751992
    • Schwarcz, W. D., Barroso, S. P. C., Gomes, A. M. O., Johnson, J. E., Schneemann, A., Oliveira, A. C., Silva, J. L. Virus stability and protein-nucleic acid interaction as studied by high-pressure effects on nodaviruses Cellular and Molecular Biology  2004 50:419-427  PMID:15529751
    • Tihova, M., Dryden, K. A., Le, T. V. L., Harvey, S. C., Johnson, J. E., Yeager, M., Schneemann, A. Nodavirus coat protein imposes dodecahedral rna structure independent of nucleotide sequence and length Journal of Virology  2004 78:2897-2905  DOI:10.1128/jvi.78.6.2897-2905.2004  PMID:14990708
    • Krishna, N. K., Marshall, D., Schneemann, A. Analysis of rna packaging in wild-type and mosaic protein capsids of flock house virus using recombinant baculovirus vectors Virology  2003 305:10-24  DOI:10.1006/viro.2002.1740  PMID:12504536
    • Schneemann, A., Young, M. J. Viral assembly using heterologous expression systems and cell extracts Virus Structure  2003 64:1-36  PMID:13677044
    • Taylor, D. J., Krishna, N. K., Canady, M. A., Schneemann, A., Johnson, J. E. Large-scale, ph-dependent, quaternary structure changes in an rna virus capsid are reversible in the absence of subunit autoproteolysis Journal of Virology  2002 76:9972-9980  DOI:10.1128/jvi.76.19.9972-9980.2002  PMID:12208973
    • Tang, L., Lin, C. S., Krishna, N. K., Yeager, M., Schneemann, A., Johnson, J. E. Virus-like particles of a fish nodavirus display a capsid subunit domain organization different from that of insect nodaviruses Journal of Virology  2002 76:6370-6375  DOI:10.1128/jvi.76.12.6370-6375.2002  PMID:12021370
    • Lin, C. S., Lu, M. W., Tang, L., Liu, W. T., Chao, C. B., Lin, C. J., Krishna, N. K., Johnson, J. E., Schneemann, A. Characterization of virus-like particles assembled in a recombinant baculovirus system expressing the capsid protein of a fish nodavirus Virology  2001 290:50-58  DOI:10.1006/viro.2001.1157  PMID:11883005
    • Marshall, D., Schneemann, A. Specific packaging of nodaviral rna2 requires the n-terminus of the capsid protein Virology  2001 285:165-175  DOI:10.1006/viro.2001.0951  PMID:11414816
    • Broo, K., Wei, J., Marshall, D., Brown, F., Smith, T. J., Johnson, J. E., Schneemann, A., Siuzdak, G. Viral capsid mobility: A dynamic conduit for inactivation Proceedings of the National Academy of Sciences of the United States of America  2001 98:2274-2277  DOI:10.1073/pnas.051598298  PMID:11226229  PMCID:PMC30128
    • Bothner, B., Chavez, R., Wei, J., Strupp, C., Phung, Q., Schneemann, A., Siuzdak, G. Monitoring enzyme catalysis with mass spectrometry Journal of Biological Chemistry  2000 275:13455-13459  DOI:10.1074/jbc.275.18.13455  PMID:10788458
    • Bothner, B., Schneemann, A., Marshall, D., Reddy, V., Johnson, J. E., Siuzdak, G. Crystallographically identical virus capsids display different properties in solution Nature Structural Biology  1999 6:114-116  PMID:10048920
    • Krishna, N. K., Schneemann, A. Formation of an rna heterodimer upon heating of nodavirus particles Journal of Virology  1999 73:1699-1703  PMID:9882383  PMCID:PMC104002
    • Schneemann, A., Marshall, D. Specific encapsidation of nodavirus rnas is mediated through the c terminus of capsid precursor protein alpha Journal of Virology  1998 72:8738-8746  PMID:9765417  PMCID:PMC110289
    • Dong, X. F., Natarajan, P., Tihova, M., Johnson, J. E., Schneemann, A. Particle polymorphism caused by deletion of a peptide molecular switch in a quasiequivalent icosahedral virus Journal of Virology  1998 72:6024-6033  PMID:9621065  PMCID:PMC110407
    • Schneemann, A., Reddy, V., Johnson, J. E. The structure and function of nodavirus particles: a paradigm for understanding chemical biology Advances in Virus Research  1998 50:381-446  DOI:10.1016/s0065-3527(08)60812-x  PMID:9521003
    • Schneemann, A., Schneider, P. A., Lamb, R. A., Lipkin, W. I. The remarkable coding strategy of borna-disease virus - a new member of the nonsegmented negative strand rna viruses Virology  1995 210:1-8  DOI:10.1006/viro.1995.1311  PMID:7793061
    • Schneemann, A., Schneider, P. A., Kim, S., Lipkin, W. I. Identification of signal sequences that control transcription of borna-disease virus, a nonsegmented, negative-strand rna virus Journal of Virology  1994 68:6514-6522  PMID:8083989  PMCID:PMC237072
    • Schneider, P. A., Schneemann, A., Lipkin, W. I. Rna splicing in borna-disease virus, a nonsegmented, negative-strand rna virus Journal of Virology  1994 68:5007-5012  PMID:8035500  PMCID:PMC236442
    • McKinney, B. R., Agrawal, D., Fisher, A. J., Johnson, J. E., Schneemann, A., Rueckert, R. R. Production and crystallization of virus-like particles assembled in a heterologous protein expression system Acta Crystallographica Section D-Biological Crystallography  1994 50:351-354  DOI:10.1107/s090744499400123x  PMID:15299383
    • Schneemann, A., Gallagher, T. M., Rueckert, R. R. Reconstitution of flock house provirions - a model system for studying structure and assembly Journal of Virology  1994 68:4547-4556  PMID:8207829  PMCID:PMC236381
    • Briese, T., Schneemann, A., Lewis, A. J., Park, Y. S., Kim, S., Ludwig, H., Lipkin, W. I. Genomic organization of borna-disease virus Proceedings of the National Academy of Sciences of the United States of America  1994 91:4362-4366  DOI:10.1073/pnas.91.10.4362  PMID:8183914
    • Zlotnick, A., Reddy, V. S., Dasgupta, R., Schneemann, A., Ray, W. J., Rueckert, R. R., Johnson, J. E. Capsid assembly in a family of animal viruses primes an autoproteolytic maturation that depends on a single aspartic acid residue Journal of Biological Chemistry  1994 269:13680-13684  PMID:8175803
    • Fisher, A. J., McKinney, B. R., Schneemann, A., Rueckert, R. R., Johnson, J. E. Crystallization of virus-like particles assembled from flock house virus coat protein expressed in a baculovirus system Journal of Virology  1993 67:2950-2953  PMID:8474184  PMCID:PMC237625
    • Schneemann, A., Dasgupta, R., Johnson, J. E., Rueckert, R. R. Use of recombinant baculoviruses in synthesis of morphologically distinct virus-like particles of flock house virus, a nodavirus Journal of Virology  1993 67:2756-2763  PMID:8474173  PMCID:PMC237599
    • Schneemann, A., Zhong, W. D., Gallagher, T. M., Rueckert, R. R. Maturation cleavage required for infectivity of a nodavirus Journal of Virology  1992 66:6728-6734  PMID:1404613  PMCID:PMC240169
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Research

research overview

  • Molecular determinants of viral assembly

    Virus particles contain multiple copies of structural proteins and the genomic RNA or DNA. In infected cells, these components have to come together in an ordered fashion to form the infectious progeny virion. We investigate how viruses take advantage of the structural organization of the cell and its resident organelles to assist in the assembly process. We are particularly interested in the mechanisms that ensure packaging of viral genomes that consist of multiple pieces of RNA. Our experimental approaches employ modern tools in molecular biology and virology, as well as cutting edge cell biological techniques, such as confocal microscopy, live cell imaging and EM-tomography.

    Virus-like particles as a platform for vaccine design

    Virus particles are highly immunogenic and usually induce a potent neutralizing antibody response. This is in part a consequence of the regular array of structural proteins in the virus capsid. We engineer virus-like particles to display on their surface similar arrays of proteins derived from other microbes. The goal is to use the chimeric particles as immunogens to stimulate protective antibody responses against pathogens for which effective vaccines are currently not available.

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Background

education and training

  • Ph.D. in Biochemistry, University of Wisconsin-Madison , Department of Biochemistry, with Prof. R. R. Rueckert 1992
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Contact

full name

  • Anette Schneemann

geographic location

  • Scripps California 

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