Schimmel, Paul

Faculty Member

Positions

2017 - Professor, Molecular Medicine , Scripps Research
2013 - Professor (Joint Appointment), Chemistry , Scripps Research
1997 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
1997 - Member, The Skaggs Institute for Chemical Biology , Scripps Research
John D. and Catherine T. MacArthur Professor of Biochemistry and Biophysics, Massachusetts Institute of Technology
2013 - 2017 Professor, Cell and Molecular Biology (CMB) , Scripps Research
1997 - 2012 Ernest and Jean Hahn Professor, Molecular Biology , Scripps Research

Dr. Paul Schimmel is examining the nature, origins, and boundaries of the genetic code, probing the molecular basis of tRNA specificity and the manipulative potential of tRNAs and their enzymes as tools for developing new proteins, cellular functions, and potential therapeutics.

Contact

schimmel@scripps.edu

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academic article
- Kuhle, B., Chihade, J., Schimmel, P. Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs Nature Communications 2020 11 DOI:10.1038/s41467-020-14725-y PMID:32080176 PMCID:PMC7033119
- Blocquel, D., Sun, L., Matuszekc, Z., Li, S., Weber, T., Kuhle, B., Kooi, G., Wei, N., Baets, J., Pan, T., Schimmel, P., Yang, X. L. CMT disease severity correlates with mutation-induced open conformation of histidyl-tRNA synthetase, not aminoacylation loss, in patient cells Proceedings of the National Academy of Sciences of the United States of America 2019 116:19440-19448 DOI:10.1073/pnas.1908288116 PMID:31501329
- Kanaji, T., Vo, M. N., Kanaji, S., Zarpellon, A., Shapiro, R., Morodomi, Y., Yuzuriha, A., Eto, K., Belani, R., Do, M. H., Yang, X. L., Ruggeri, Z. M., et al. Tyrosyl-tRNA synthetase stimulates thrombopoietin-independent hematopoiesis accelerating recovery from thrombocytopenia Proceedings of the National Academy of Sciences of the United States of America 2018 115:EB228-EB235 DOI:10.1073/pnas.1807000115 PMID:30104364 PMCID:PMC6126720
- Chong, Y. E., Guo, M., Yang, X. L., Kuhle, B., Naganuma, M., Sekine, S., Yokoyama, S., Schimmel, P. Distinct ways of G:U recognition by conserved tRNA binding motifs Proceedings of the National Academy of Sciences of the United States of America 2018 115:7527-7532 DOI:10.1073/pnas.1807109115 PMID:29967150 PMCID:PMC6055181
- Xu, Z., Lo, W. S., Beck, D. B., Schuch, L. A., Olahova, M., Kopajtich, R., Chong, Y. E., Alston, C. L., Seidl, E., Zhai, L., Lau, C. F., Timchak, D., et al. Bi-allelic mutations in phe-tRNA synthetase associated with a multi-system pulmonary disease Support non-translational function American Journal of Human Genetics 2018 103:100-114 DOI:10.1016/j.ajhg.2018.06.006 PMID:29979980 PMCID:PMC6035289
- Vo, M. N., Terrey, M., Lee, J. W., Roy, B., Moresco, J. J., Sun, L. T., Fu, H. J., Liu, Q., Weber, T. G., Yates III, J. R., Fredrick, K., Schimmel, P., et al. ANKRD16 prevents neuron loss caused by an editing-defective tRNA synthetase Nature 2018 557:510-515 DOI:10.1038/s41586-018-0137-8 PMID:29769718 PMCID:PMC5973781
- Xu, X., Zhou, H., Zhou, Q., Hong, F., Vo, M. N., Niu, W., Wang, Z., Xiong, X., Nakamura, K., Wakasugi, K., Schimmel, P., Yang, X. L. An alternative conformation of human TrpRS suggests a role of zinc in activating non-enzymatic function Rna Biology 2018 15:649-658 DOI:10.1080/15476286.2017.1377868 PMID:28910573 PMCID:PMC6103731
- Schimmel, P. The emerging complexity of the tRNA world: mammalian tRNAs beyond protein synthesis Nature Reviews Molecular Cell Biology 2018 19:45-58 DOI:10.1038/nrm.2017.77 PMID:28875994
- Song, Y., Zhou, H., Vo, M. N., Shi, Y., Nawaz, M. H., Vargas-Rodriguez, O., Diedrich, J. K., Yates III, J. R., Kishi, S., Musier-Forsyth, K., Schimmel, P. Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid Nature Communications 2017 8 DOI:10.1038/s41467-017-02201-z PMID:29273753 PMCID:PMC5741666
- Blocquel, D., Li, S., Wei, N., Daub, H., Sajish, M., Erfurth, M. L., Kooi, G., Zhou, J., Bai, G., Schimmel, P., Jordanova, A., Yang, X. L. Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy Nucleic Acids Research 2017 45:8091-8104 DOI:10.1093/nar/gkx455 PMID:28531329
- Sun, L., Song, Y., Blocquel, D., Yang, X. L., Schimmel, P. Two crystal structures reveal design for repurposing the C-Ala domain of human AlaRS Proceedings of the National Academy of Sciences of the United States of America 2016 113:14300-14305 DOI:10.1073/pnas.1617316113 PMID:27911835 PMCID:PMC5167178
- Sun, L., Gomes, A. C., He, W., Zhou, H., Wang, X., Pan, D. W., Schimmel, P., Pan, T., Yang, X. L. Evolutionary gain of alanine mischarging to noncognate tRNAs with a G4:U69 base pair Journal of the American Chemical Society 2016 138:12948-12955 DOI:10.1021/jacs.6b07121 PMID:27622773
- Song, Y., Shi, Y., Carland, T. M., Lian, S., Sasaki, T., Schork, N. J., Head, S. R., Kishi, S., Schimmel, P. p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish Proceedings of the National Academy of Sciences of the United States of America 2016 113:8460-8465 DOI:10.1073/pnas.1608139113 PMID:27402763 PMCID:PMC4968768
- Wei, Z., Xu, Z., Liu, X., Lo, W. S., Ye, F., Lau, C. F., Wang, F., Zhou, J. J., Nangle, L. A., Yang, X. L., Zhang, M., Schimmel, P. Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase Nucleic Acids Research 2016 44:1247-1255 DOI:10.1093/nar/gkw002 PMID:26773056 PMCID:PMC4756856
- Schimmel, P. Alexander Rich (1924-2015) Nature 2015 521:291 DOI:10.1038/521291a PMID:25993953
- Herman, J. D., Pepper, L. R., Cortese, J. F., Estiu, G., Galinsky, K., Zuzarte-Luis, V., Derbyshire, E. R., Ribacke, U., Lukens, A. K., Santos, S. A., Patel, V., Clish, C. B., et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs Science Translational Medicine 2015 7 DOI:10.1126/scitranslmed.aaa3575 PMID:25995223 PMCID:PMC4675670
- Sajish, M., Schimmel, P. A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol Nature 2015 519:370-373 DOI:10.1038/nature14028 PMID:25533949 PMCID:PMC4368482
- Liu, Y., Satz, J. S., Vo, M. N., Nangle, L. A., Schimmel, P., Ackerman, S. L. Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy Proceedings of the National Academy of Sciences of the United States of America 2014 111:17570-17575 DOI:10.1073/pnas.1420196111 PMID:25422440 PMCID:PMC4267364
- Ishimura, R., Nagy, G., Dotu, I., Zhou, H., Yang, X. L., Schimmel, P., Senju, S., Nishimura, Y., Chuang, J. H., Ackerman, S. L. Ribosome stalling induced by mutation of a CNS-specific tRNA causes neurodegeneration Science 2014 345:455-459 DOI:10.1126/science.1249749 PMID:25061210 PMCID:PMC4281038
- Lo, W. S., Gardiner, E., Xu, Z., Lau, C. F., Wang, F., Zhou, J. J., Mendlein, J. D., Nangle, L. A., Chiang, K. P., Yang, X. L., Au, K. F., Wong, W. H., et al. Human tRNA synthetase catalytic nulls with diverse functions Science 2014 345:328-332 DOI:10.1126/science.1252943 PMID:25035493 PMCID:PMC4188629
- Zhou, J. J., Wang, F., Xu, Z., Lo, W. S., Lau, C. F., Chiang, K. P., Nangle, L. A., Ashlock, M. A., Mendlein, J. D., Yang, X. L., Zhang, M., Schimmel, P. Secreted histidyl-tRNA synthetase splice variants elaborate major epitopes for autoantibodies in inflammatory myositis Journal of Biological Chemistry 2014 289:19269-19275 DOI:10.1074/jbc.C114.571026 PMID:24898250 PMCID:PMC4094037
- Naganuma, M., Sekine, S., Chong, Y. E., Guo, M., Yang, X. L., Gamper, H., Hou, Y. M., Schimmel, P., Yokoyama, S. The selective tRNA aminoacylation mechanism based on a single G.U pair Nature 2014 510:507-511 DOI:10.1038/nature13440 PMID:24919148 PMCID:PMC4323281
- Wang, F., Xu, Z., Zhou, J., Lo, W. S., Lau, C. F., Nangle, L. A., Yang, X. L., Zhang, M., Schimmel, P. Regulated capture by exosomes of mRNAs for cytoplasmic tRNA synthetases Journal of Biological Chemistry 2013 288:29223-29228 DOI:10.1074/jbc.C113.490599 PMID:24003230 PMCID:PMC3795223
- Klipcan, L., Safro, M., Schimmel, P. Anticodon G recognition by tRNA synthetases mimics the tRNA core Trends in Biochemical Sciences 2013 38:229-232 DOI:10.1016/j.tibs.2012.11.002 PMID:23266103 PMCID:PMC3634914
- Guo, M., Schimmel, P. Essential nontranslational functions of tRNA synthetases Nature Chemical Biology 2013 9:145-153 DOI:10.1038/nchembio.1158 PMID:23416400 PMCID:PMC3773598
- Zhou, H. H., Sun, L. T., Yang, X. L., Schimmel, P. ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase Nature 2013 494:121-124 DOI:10.1038/nature11774 PMID:23263184 PMCID:PMC3569068
- Ofir-Birin, Y., Fang, P. F., Bennett, S. P., Zhang, H. M., Wang, J., Rachmin, I., Shapiro, R., Song, J., Dagan, A., Pozo, J., Kim, S., Marshall, A. G., et al. Structural switch of lysyl-tRNA synthetase between translation and transcription Molecular Cell 2013 49:30-42 DOI:10.1016/j.molcel.2012.10.010 PMID:23159739 PMCID:PMC3766370
- Guo, M., Schimmel, P. Homeostatic mechanisms by alternative forms of tRNA synthetases Trends in Biochemical Sciences 2012 37:401-403 DOI:10.1016/j.tibs.2012.07.003 PMID:22858252 PMCID:PMC3459177
- Xu, Z. W., Wei, Z. Y., Zhou, J. J., Ye, F., Lo, W. S., Wang, F., Lau, C. F., Wu, J. J., Nangle, L. A., Chiang, K. P., Yang, X. L., Zhang, M. J., et al. Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing Structure 2012 20:1470-1477 DOI:10.1016/j.str.2012.08.001 PMID:22958643 PMCID:PMC3485694
- Wang, J., Fang, P. F., Schimmel, P., Guo, M. Side chain independent recognition of aminoacyl adenylates by the Hint1 transcription suppressor Journal of Physical Chemistry B 2012 116:6798-6805 DOI:10.1021/jp212457w PMID:22329685 PMCID:PMC3375047
- Lee, P. S., Zhang, H. M., Marshall, A. G., Yang, X. L., Schimmel, P. Uncovering of a short internal peptide activates a tRNA synthetase procytokine Journal of Biological Chemistry 2012 287:20504-20508 DOI:10.1074/jbc.C112.369439 PMID:22549774 PMCID:PMC3370235
- Sajish, M., Zhou, Q. S., Kishi, S., Valdez, D. M., Kapoor, M., Guo, M., Lee, S., Kim, S., Yang, X. L., Schimmel, P. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling Nature Chemical Biology 2012 8:547-554 DOI:10.1038/nchembio.937 PMID:22504299 PMCID:PMC3780985
- Park, M. C., Kang, T., Jin, D., Han, J. M., Kim, S. B., Park, Y. J., Cho, K., Park, Y. W., Guo, M., He, W., Yang, X. L., Schimmel, P., et al. Secreted human glycyl-tRNA synthetase implicated in defense against ERK-activated tumorigenesis Proceedings of the National Academy of Sciences of the United States of America 2012 109:E640-E647 DOI:10.1073/pnas.1200194109 PMID:22345558 PMCID:PMC3306665
- Guo, M., Schimmel, P. Structural analyses clarify the complex control of mistranslation by tRNA synthetases Current Opinion in Structural Biology 2012 22:119-126 DOI:10.1016/j.sbi.2011.11.008 PMID:22155179 PMCID:PMC3288634
- Schimmel, P. Mistranslation and its control by tRNA synthetases Philosophical Transactions of the Royal Society B-Biological Sciences 2011 366:2965-2971 DOI:10.1098/rstb.2011.0158 PMID:21930589 PMCID:PMC3158927
- Yang, X. L., Schimmel, P. Functional expansion of the tRNA world under stress Molecular Cell 2011 43:500-502 DOI:10.1016/j.molcel.2011.08.004 PMID:21855789 PMCID:PMC3163667
- Fang, P. F., Zhang, H. M., Shapiro, R., Marshall, A. G., Schimmel, P., Yang, X. L., Guo, M. Structural context for mobilization of a human tRNA synthetase from its cytoplasmic complex Proceedings of the National Academy of Sciences of the United States of America 2011 108:8239-8244 DOI:10.1073/pnas.1100224108 PMID:21536907 PMCID:PMC3100937
- Vo, M. N., Yang, X. L., Schimmel, P. Dissociating quaternary structure regulates cell-signaling functions of a secreted human tRNA synthetase Journal of Biological Chemistry 2011 286:11563-11568 DOI:10.1074/jbc.C110.213876 PMID:21310955 PMCID:PMC3064210
- Schimmel, P. The RNP bridge between two worlds Nature Reviews Molecular Cell Biology 2011 12:135 DOI:10.1038/nrm3061 PMID:21285979
- Nawaz, M. H., Merriman, E., Yang, X. L., Schimmel, P. p23(H) implicated as cis/trans regulator of AlaXp-directed editing for mammalian cell homeostasis Proceedings of the National Academy of Sciences of the United States of America 2011 108:2723-2728 DOI:10.1073/pnas.1019400108 PMID:21285375 PMCID:PMC3041069
- Guo, M., Shapiro, R., Morris, G. M., Yang, X. L., Schimmel, P. Packaging HIV virion components through dynamic equilibria of a human tRNA synthetase Journal of Physical Chemistry B 2010 114:16273-16279 DOI:10.1021/jp1082517 PMID:21058683 PMCID:PMC3042951
- Han, G. W., Yang, X. L., McMullan, D., Chong, Y. E., Krishna, S. S., Rife, C. L., Weekes, D., Brittain, S. M., Abdubek, P., Ambing, E., Astakhova, T., Axelrod, H. L., et al. Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2010 66:1326-1334 DOI:10.1107/s1744309110037619 PMID:20944229 PMCID:PMC2954223
- Guo, M., Yang, X. L., Schimmel, P. New functions of aminoacyl-tRNA synthetases beyond translation Nature Reviews Molecular Cell Biology 2010 11:668-674 DOI:10.1038/nrm2956 PMID:20700144 PMCID:PMC3042954
- Guo, M., Shapiro, R., Schimmel, P., Yang, X. L. Introduction of a leucine half-zipper engenders multiple high-quality crystals of a recalcitrant tRNA synthetase Acta Crystallographica Section D-Biological Crystallography 2010 66:243-250 DOI:10.1107/s0907444909055462 PMID:20179335 PMCID:PMC2827346
- Guo, M., Schimmel, P., Yang, X. L. Functional expansion of human tRNA synthetases achieved by structural inventions FEBS Letters 2010 584:434-442 DOI:10.1016/j.febslet.2009.11.064 PMID:19932696 PMCID:PMC2826164
- Zhou, Q. S., Kapoor, M., Guo, M., Belani, R., Xu, X. L., Kiosses, W. B., Hanan, M., Park, C., Armour, E., Do, M. H., Nangle, L. A., Schimmel, P., et al. Orthogonal use of a human tRNA synthetase active site to achieve multifunctionality Nature Structural & Molecular Biology 2010 17:57-61 DOI:10.1038/nsmb.1706 PMID:20010843 PMCID:PMC3042952
- Guo, M., Chong, Y. E., Shapiro, R., Beebe, K., Yang, X. L., Schimmel, P. Paradox of mistranslation of serine for alanine caused by AlaRS recognition dilemma Nature 2009 462:808-812 DOI:10.1038/nature08612 PMID:20010690 PMCID:PMC2799227
- Sankaran, B., Bonnett, S. A., Shah, K., Gabriel, S., Reddy, R., Schimmel, P., Rodionov, D. A., de Crecy-Lagard, V., Helmann, J. D., Iwata-Reuyl, D., Swairjo, M. A. Zinc-independent folate biosynthesis: genetic, biochemical, and structural investigations reveal new metal dependence for GTP cyclohydrolase IB Journal of Bacteriology 2009 191:6936-6949 DOI:10.1128/jb.00287-09 PMID:19767425 PMCID:PMC2772490
- Storkebaum, E., Leitao-Goncalves, R., Godenschwege, T., Nangle, L., Mejia, M., Bosmans, I., Ooms, T., Jacobs, A., Van Dijck, P., Yang, X. L., Schimmel, P., Norga, K., et al. Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy Proceedings of the National Academy of Sciences of the United States of America 2009 106:11782-11787 DOI:10.1073/pnas.0905339106 PMID:19561293 PMCID:PMC2702257
- El Yacoubi, B., Lyons, B., Cruz, Y., Reddy, R., Nordin, B., Agnelli, F., Williamson, J. R., Schimmel, P., Swairjo, M. A., de Crecy-Lagard, V. The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA Nucleic Acids Research 2009 37:2894-2909 DOI:10.1093/nar/gkp152 PMID:19287007 PMCID:PMC2685093
- Schimmel, P., Guo, M. A tipping point for mistranslation and disease Nature Structural & Molecular Biology 2009 16:348-349 DOI:10.1038/nsmb0409-348 PMID:19343067
- Schimmel, P., Guo, M. Ancient tRNA synthetase meets modern structural biology Structure 2009 17:315-317 DOI:10.1016/j.str.2009.02.002 PMID:19278642
- Guo, M., Chong, Y. E., Beebe, K., Shapiro, R., Yang, X. L., Schimmel, P. The C-Ala domain brings together editing and aminoacylation functions on one tRNA Science 2009 325:744-747 DOI:10.1126/science.1174343 PMID:19661429 PMCID:PMC4559334
- Chong, Y. E., Yang, X. L., Schimmel, P. Natural homolog of tRNA synthetase editing domain rescues conditional lethality caused by mistranslation Journal of Biological Chemistry 2008 283:30073-30078 DOI:10.1074/jbc.M805943200 PMID:18723508 PMCID:PMC2573062
- Schimmel, P. An editing activity that prevents mistranslation and connection to disease Journal of Biological Chemistry 2008 283:28777-28782 DOI:10.1074/jbc.X800007200 PMID:18640977 PMCID:PMC2661996
- Schimmel, P. Development of tRNA synthetases and connection to genetic code and disease Protein Science 2008 17:1643-1652 DOI:10.1110/ps.037242.108 PMID:18765819 PMCID:PMC2548368
- Cheng, G., Zhang, H., Yang, X. L., Tzima, E., Ewalt, K. L., Schimmel, P., Faber, J. E. Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability American Journal of Physiology-Regulatory Integrative and Comparative Physiology 2008 295:R1138-R1146 DOI:10.1152/ajpregu.90519.2008 PMID:18753262
- Park, S. G., Schimmel, P., Kim, S. Aminoacyl tRNA synthetases and their connections to disease Proceedings of the National Academy of Sciences of the United States of America 2008 105:11043-11049 DOI:10.1073/pnas.0802862105 PMID:18682559 PMCID:PMC2516211
- Greenberg, Y., King, M., Kiosses, W. B., Ewalt, K., Yang, X., Schimmel, P., Reader, J. S., Tzima, E. The novel fragment of tyrosyl tRNA synthetase, mini-TyrRS, is secreted to induce an angiogenic response in endothelial cells FASEB Journal 2008 22:1597-1605 DOI:10.1096/fj.07-9973com PMID:18165356
- Guo, M., Ignatov, M., Musier-Forsyth, K., Schimmel, P., Yang, X. L. Crystal structure of tetrameric form of human lysyl-tRNA synthetase: implications for multisynthetase complex formation Proceedings of the National Academy of Sciences of the United States of America 2008 105:2331-2336 DOI:10.1073/pnas.0712072105 PMID:18272479 PMCID:PMC2268136
- Zhou, Q. S., Kiosses, W. B., Liu, J., Schimmel, P. Tumor endothelial cell tube formation model for determining anti-angiogenic activity of a tRNA synthetase cytokine Methods 2008 44:190-195 DOI:10.1016/j.ymeth.2007.10.004 PMID:18241800 PMCID:PMC3835186
- Kapoor, M., Zhou, Q., Otero, F., Myers, C. A., Bates, A., Belani, R., Liu, J., Luo, J. K., Tzima, E., Zhang, D. E., Yang, X. L., Schimmel, P. Evidence for annexin II-S100A10 complex and plasmin in mobilization of cytokine activity of human TrpRS Journal of Biological Chemistry 2008 283:2070-2077 DOI:10.1074/jbc.M706028200 PMID:17999956
- Beebe, K., Mock, M., Merriman, E., Schimmel, P. Distinct domains of tRNA synthetase recognize the same base pair Nature 2008 451:90-93 DOI:10.1038/nature06454 PMID:18172502
- Yang, X. L., Kapoor, M., Otero, F. J., Slike, B. M., Tsuruta, H., Frausto, R., Bates, A., Ewalt, K. L., Cheresh, D. A., Schimmel, P. Gain-of-function mutational activation of human tRNA synthetase procytokine Chemistry & Biology 2007 14:1323-1333 DOI:10.1016/j.chembiol.2007.10.016 PMID:18096501 PMCID:PMC2693404
- Zubieta, C., Krishna, S. S., Kapoor, M., Kozbial, P., McMullan, D., Axelrod, H. L., Miller, M. D., Abdubek, P., Ambing, E., Astakhova, T., Carlton, D., Chiu, H. J., et al. Crystal structures of two novel dye-decolorizing peroxidases reveal a β-barrel fold with a conserved heme-binding motif Proteins-Structure Function and Bioinformatics 2007 69:223-233 DOI:10.1002/prot.21550 PMID:17654545
- Zubieta, C., Joseph, R., Krishna, S. S., McMullan, D., Kapoor, M., Axelrod, H. L., Miller, M. D., Abdubek, P., Acosta, C., Astakhova, T., Carlton, D., Chiu, H. J., et al. Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA Proteins-Structure Function and Bioinformatics 2007 69:234-243 DOI:10.1002/prot.21673 PMID:17654547
- Waas, W. F., Schimmel, P. Evidence that tRNA synthetase-directed proton transfer stops mistranslation Biochemistry 2007 46:12062-12070 DOI:10.1021/bi7007454 PMID:17924654
- Waas, W. F., Druzina, Z., Hanan, M., Schimmel, P. Role of a tRNA base modification and its precursors in frameshifting in eukaryotes Journal of Biological Chemistry 2007 282:26026-26034 DOI:10.1074/jbc.M703391200 PMID:17623669
- Beebe, K., Waas, W., Druzina, Z., Guo, M., Schimmel, P. A universal plate format for increased throughput of assays that monitor multiple aminoacyl transfer RNA synthetase activities Analytical Biochemistry 2007 368:111-121 DOI:10.1016/j.ab.2007.05.013 PMID:17603003 PMCID:PMC3833075
- Bacher, J. A., Waas, W. F., Metzgar, D., de Crecy-Lagard, V., Schimmel, P. Genetic code ambiguity confers a selective advantage on Acinetobacter baylyi Journal of Bacteriology 2007 189:6494-6496 DOI:10.1128/jb.00622-07 PMID:17616603 PMCID:PMC1951902
- Nangle, L. A., Zhang, W., Xie, W., Yang, X. L., Schimmel, P. Charcot-Marie-Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect Proceedings of the National Academy of Sciences of the United States of America 2007 104:11239-11244 DOI:10.1073/pnas.0705055104 PMID:17595294 PMCID:PMC2040883
- Yang, X. L., Guo, M., Kapoor, M., Ewalt, K. L., Otero, F. J., Skene, R. J., McRee, D. E., Schimmel, P. Functional and crystal structure analysis of active site adaptations of a potent anti-angiogenic human tRNA synthetase Structure 2007 15:793-805 DOI:10.1016/j.str.2007.05.009 PMID:17637340 PMCID:PMC2104486
- Xie, W., Nangle, L. A., Zhang, W., Schimmel, P., Yang, X. L. Long-range structural effects of a Charcot-Marie-Tooth disease-causing mutation in human glycyl-tRNA synthetase Proceedings of the National Academy of Sciences of the United States of America 2007 104:9976-9981 DOI:10.1073/pnas.0703908104 PMID:17545306 PMCID:PMC1891255
- Bacher, J. M., Schimmel, P. An editing-defective aminoacyl-tRNA synthetase is mutagenic in aging bacteria via the SOS response Proceedings of the National Academy of Sciences of the United States of America 2007 104:1907-1912 DOI:10.1073/pnas.0610835104 PMID:17264207 PMCID:PMC1794292
- Xie, W., Schimmel, P., Yang, X. L. Crystallization and preliminary X-ray analysis of a native human tRNA synthetase whose allelic variants are associated with Charcot-Marie-Tooth disease Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2006 62:1243-1246 DOI:10.1107/s1744309106046434 PMID:17142907 PMCID:PMC2225372
- Schimmel, P., Yang, X. L. Perfecting the genetic code with an RNP complex Structure 2006 14:1729-1730 DOI:10.1016/j.str.2006.11.002 PMID:17161363
- Nangle, L. A., Motta, C. M., Schimmel, P. Global effects of mistranslation from an editing defect in mammalian cells Chemistry & Biology 2006 13:1091-1100 DOI:10.1016/j.chembiol.2006.08.011 PMID:17052613
- Seburn, K. L., Nangle, L. A., Cox, G. A., Schimmel, P., Burgess, R. W. An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model Neuron 2006 51:715-726 DOI:10.1016/j.neuron.2006.08.027 PMID:16982418
- Tamura, K., Schimmel, P. R. Chiral-selective aminoacylation of an RNA minihelix: mechanistic features and chiral suppression Proceedings of the National Academy of Sciences of the United States of America 2006 103:13750-13752 DOI:10.1073/pnas.0606070103 PMID:16950872 PMCID:PMC1564265
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- Lovato, M. A., Swairjo, M. A., Schimmel, P. Positional recognition of a tRNA determinant dependent on a peptide insertion Molecular Cell 2004 13:843-851 DOI:10.1016/s1097-2765(04)00125-x PMID:15053877
- de Pereda, J. M., Waas, W. F., Jan, Y. W., Ruoslahti, E., Schimmel, P., Pascual, J. Crystal structure of a human peptidyl-tRNA hydrolase reveals a new fold and suggests basis for a bifunctional activity Journal of Biological Chemistry 2004 279:8111-8115 DOI:10.1074/jbc.M311449200 PMID:14660562
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- Metzgar, D., Bacher, J. M., Pezo, V., Reader, J., Doring, V., Schimmel, P., Marliere, P., de Crecy-Lagard, V. Acinetobacter sp. ADP1: an ideal model organism for genetic analysis and genome engineering Nucleic Acids Research 2004 32:5780-5790 DOI:10.1093/nar/gkh881 PMID:15514111 PMCID:PMC528786
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- Tzima, E., Reader, J. S., Irani-Tehrani, M., Ewalt, K. L., Schwartz, M. A., Schimmel, P. Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells Proceedings of the National Academy of Sciences of the United States of America 2003 100:14903-14907 DOI:10.1073/pnas.2436330100 PMID:14630953 PMCID:PMC299850
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- Tamura, K., Schimmel, P. Peptide synthesis with a template-like RNA guide and aminoacyl phosphate adaptors Proceedings of the National Academy of Sciences of the United States of America 2003 100:8666-8669 DOI:10.1073/pnas.1432909100 PMID:12857953 PMCID:PMC166369
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- Schimmel, P., Tamura, K. tRNA structure goes from L to lambda Cell 2003 113:276-278 DOI:10.1016/s0092-8674(03)00313-1 PMID:12732135
- Wang, C. C., Chang, K. J., Tang, H. L., Hsieh, C. J., Schimmel, P. Mitochondrial form of a tRNA synthetase can be made bifunctional by manipulating its leader peptide Biochemistry 2003 42:1646-1651 DOI:10.1021/bi025964c PMID:12578378
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- Doring, V., Mootz, H. D., Nangle, L. A., Hendrickson, T. L., de Crecy-Lagard, V., Schimmel, P., Marliere, P. Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway Science 2001 292:501-504 DOI:10.1126/science.1057718 PMID:11313495
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- Morales, A. J., Swairjo, M. A., Schimmel, P. Structure-specific tRNA-binding protein from the extreme thermophile Aquifex aeolicus EMBO Journal 1999 18:3475-3483 DOI:10.1093/emboj/18.12.3475 PMID:10369686 PMCID:PMC1171426
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- Wakasugi, K., Schimmel, P. Two distinct cytokines released from a human aminoacyl-tRNA synthetase Science 1999 284:147-151 DOI:10.1126/science.284.5411.147 PMID:10102815
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- Nordin, B. E., Schimmel, P. RNA determinants for translational editing. Mischarging a minihelix substrate by a tRNA synthetase Journal of Biological Chemistry 1999 274:6835-6838 DOI:10.1074/jbc.274.11.6835 PMID:10066735
- Schimmel, P., Ribas de Pouplana, L. Genetic code origins: experiments confirm phylogenetic predictions and may explain a puzzle Proceedings of the National Academy of Sciences of the United States of America 1999 96:327-328 DOI:10.1073/pnas.96.2.327 PMID:9892630 PMCID:PMC33543
- Nureki, O., Vassylyev, D. G., Tateno, M., Shimada, A., Nakama, T., Fukai, S., Konno, M., Hendrickson, T. L., Schimmel, P., Yokoyama, S. Proofreading by isoleucyl-transfer rna synthetase. Response Science 1999 283:459a DOI:10.1126/science.283.5401.459a
- Schimmel, P., Tao, J. S., Hill, J. Aminoacyl tRNA synthetases as targets for new anti-infectives FASEB Journal 1998 12:1599-1609 PMID:9837850
- Alexander, R. W., Nordin, B. E., Schimmel, P. Activation of microhelix charging by localized helix destabilization Proceedings of the National Academy of Sciences of the United States of America 1998 95:12214-12219 DOI:10.1073/pnas.95.21.12214 PMID:9770466 PMCID:PMC22811
- Henderson, B. S., Beuning, P. J., Shi, J. P., Bald, R., Furste, J. P., Erdmann, V. A., Musier-Forsyth, K., Schimmel, P. Subtle functional interactions in the RNA minor groove at a nonessential base pair Journal of the American Chemical Society 1998 120:9110-9111 DOI:10.1021/ja9809152
- Schimmel, P., Alexander, R. Diverse RNA substrates for aminoacylation: clues to origins? Proceedings of the National Academy of Sciences of the United States of America 1998 95:10351-10353 DOI:10.1073/pnas.95.18.10351 PMID:9724705 PMCID:PMC33886
- Chihade, J. W., Hayashibara, K., Shiba, K., Schimmel, P. Strong selective pressure to use G:U to mark an RNA acceptor stem for alanine Biochemistry 1998 37:9193-9202 DOI:10.1021/bi9804636 PMID:9636067
- Nureki, O., Vassylyev, D. G., Tateno, M., Shimada, A., Nakama, T., Fukai, S., Konno, M., Hendrickson, T. L., Schimmel, P., Yokoyama, S. Enzyme structure with two catalytic sites for double-sieve selection of substrate Science 1998 280:578-582 DOI:10.1126/science.280.5363.578 PMID:9554847
- Sardesai, N. Y., Schimmel, P. Noncovalent assembly of microhelix recognition by a class II tRNA synthetase Journal of the American Chemical Society 1998 120:3269-3270 DOI:10.1021/ja9742287
- Wakasugi, K., Quinn, C. L., Tao, N. J., Schimmel, P. Genetic code in evolution: switching species-specific aminoacylation with a peptide transplant EMBO Journal 1998 17:297-305 DOI:10.1093/emboj/17.1.297 PMID:9427763 PMCID:PMC1170380
- Ribas de Pouplana, L., Buechter, D., Sardesai, N. Y., Schimmel, P. Functional analysis of peptide motif for RNA microhelix binding suggests new family of RNA-binding domains EMBO Journal 1998 17:5449-5457 DOI:10.1093/emboj/17.18.5449 PMID:9736622 PMCID:PMC1170870
- Ribas de Pouplana, L., Turner, R. J., Steer, B. A., Schimmel, P. Genetic code origins: tRNAs older than their synthetases? Proceedings of the National Academy of Sciences of the United States of America 1998 95:11295-11300 DOI:10.1073/pnas.95.19.11295 PMID:9736730 PMCID:PMC21636
- Schimmel, P., Alexander, R. Perspectives: protein synthesis. All you need is RNA Science 1998 281:658-659 DOI:10.1126/science.281.5377.658 PMID:9714675
- Shiba, K., Motegi, H., Schimmel, P. Maintaining genetic code through adaptations of tRNA synthetases to taxonomic domains Trends in Biochemical Sciences 1997 22:453-457 DOI:10.1016/s0968-0004(97)01135-3 PMID:9433122
- Frugier, M., Schimmel, P. Subtle atomic group discrimination in the RNA minor groove Proceedings of the National Academy of Sciences of the United States of America 1997 94:11291-11294 DOI:10.1073/pnas.94.21.11291 PMID:9326602 PMCID:PMC23445
- Beuning, P. J., Yang, F., Schimmel, P., Musier-Forsyth, K. Specific atomic groups and RNA helix geometry in acceptor stem recognition by a tRNA synthetase Proceedings of the National Academy of Sciences of the United States of America 1997 94:10150-10154 DOI:10.1073/pnas.94.19.10150 PMID:9294178 PMCID:PMC23330
- Schimmel, P., Soll, D. When protein engineering confronts the tRNA world Proceedings of the National Academy of Sciences of the United States of America 1997 94:10007-10009 DOI:10.1073/pnas.94.19.10007 PMID:9294151 PMCID:PMC33764
- Shiba, K., Stello, T., Motegi, H., Noda, T., Musier-Forsyth, K., Schimmel, P. Human lysyl-tRNA synthetase accepts nucleotide 73 variants and rescues Escherichia coli double-defective mutant Journal of Biological Chemistry 1997 272:22809-22816 DOI:10.1074/jbc.272.36.22809 PMID:9278442
- Hale, S. P., Schimmel, P. DNA aptamer targets translational editing motif in a tRNA synthetase Tetrahedron 1997 53:11985-11994 DOI:10.1016/s0040-4020(97)00711-4
- Sen, S., Zhou, H. Y., Ripmaster, T., Hittelman, W. N., Schimmel, P., White, R. A. Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent Proceedings of the National Academy of Sciences of the United States of America 1997 94:6164-6169 DOI:10.1073/pnas.94.12.6164 PMID:9177188 PMCID:PMC21020
- Glasfeld, E., Schimmel, P. Zinc-dependent tRNA binding by a peptide element within a tRNA synthetase Biochemistry 1997 36:6739-6744 DOI:10.1021/bi970151n PMID:9184155
- Henderson, B. S., Schimmel, P. RNA-RNA interactions between oligonucleotide substrates for aminoacylation Bioorganic & Medicinal Chemistry 1997 5:1071-1079 DOI:10.1016/s0968-0896(97)00043-6 PMID:9222500
- Nair, S., Ribas de Pouplana, L., Houman, F., Avruch, A., Shen, X. Y., Schimmel, P. Species-specific tRNA recognition in relation to tRNA synthetase contact residues Journal of Molecular Biology 1997 269:1-9 DOI:10.1006/jmbi.1997.1025 PMID:9192996
- Hale, S. P., Auld, D. S., Schmidt, E., Schimmel, P. Discrete determinants in transfer RNA for editing and aminoacylation Science 1997 276:1250-1252 DOI:10.1126/science.276.5316.1250 PMID:9157882
- Whelihan, E. F., Schimmel, P. Rescuing an essential enzyme-RNA complex with a non-essential appended domain EMBO Journal 1997 16:2968-2974 DOI:10.1093/emboj/16.10.2968 PMID:9184240 PMCID:PMC1169904
- Schimmel, P., Frugier, M., Glasfeld, E. Peptides for RNA discrimination and for assembly of enzymes that act on RNA Nucleic Acids Symposium Series 1997 1 PMID:9478188
- Ribas de Pouplana, L., Schimmel, P. Reconstruction of quaternary structures of class II tRNA synthetases by rational mutagenensis of a conserved domain Biochemistry 1997 36:15041-15048 DOI:10.1021/bi971788+ PMID:9398230
- Michaels, J. E. A., Schimmel, P., Shiba, K., Miller, W. T. Dominant negative inhibition by fragments of a monomeric enzyme Proceedings of the National Academy of Sciences of the United States of America 1996 93:14452-14455 DOI:10.1073/pnas.93.25.14452 PMID:8962072 PMCID:PMC26153
- Schimmel, P., Musier-Forsyth, K. 'Distorted' RNA helix recognition Nature 1996 384:422 DOI:10.1038/384422a0 PMID:8945467
- Lin, L., Hale, S. P., Schimmel, P. Aminoacylation error correction Nature 1996 384:33-34 DOI:10.1038/384033b0 PMID:8900273
- Sassanfar, M., Kranz, J. E., Gallant, P., Schimmel, P., Shiba, K. A eubacterial Mycobacterium tuberculosis tRNA synthetase is eukaryote-like and resistant to a eubacterial-specific antisynthetase drug Biochemistry 1996 35:9995-10003 DOI:10.1021/bi9603027 PMID:8756461
- Schimmel, P. Origin of genetic code: a needle in the haystack of tRNA sequences Proceedings of the National Academy of Sciences of the United States of America 1996 93:4521-4522 DOI:10.1073/pnas.93.10.4521 PMID:8643435
- Lin, L., Schimmel, P. Mutational analysis suggests the same design for editing activities of two tRNA synthetases Biochemistry 1996 35:5596-5601 DOI:10.1021/bi960011y PMID:8611551
- Glasfeld, E., Landro, J. A., Schimmel, P. C-terminal zinc-containing peptide required for RNA recognition by a class I tRNA synthetase Biochemistry 1996 35:4139-4145 DOI:10.1021/bi9527810 PMID:8672449
- Hale, S. P., Schimmel, P. Protein synthesis editing by a DNA aptamer Proceedings of the National Academy of Sciences of the United States of America 1996 93:2755-2758 DOI:10.1073/pnas.93.7.2755 PMID:8610114 PMCID:PMC39704
- Auld, D. S., Schimmel, P. Single sequence of a helix-loop peptide confers functional anticodon recognition on two tRNA synthetases EMBO Journal 1996 15:1142-1148 PMID:8605884 PMCID:PMC450012
- Gale, A. J., Shi, J. P., Schimmel, P. Evidence that specificity of microhelix charging by a class I tRNA synthetase occurs in the transition state of catalysis Biochemistry 1996 35:608-615 DOI:10.1021/bi9520904 PMID:8555234
- Ribas de Pouplana, L., Auld, D. S., Kim, S. H., Schimmel, P. A mechanism for reducing entropic cost of induced fit in protein-RNA recognition Biochemistry 1996 35:8095-8102 DOI:10.1021/bi960256a PMID:8679560
- Schimmel, P. A two-way street between the university and the biotechnology enterprise Journal of NIH Research 1996 8:41-43
- Gale, A. J., Schimmel, P. Affinity coelectrophoresis for dissecting protein-RNA domain-domain interactions in a tRNA synthetase system Pharmaceutica Acta Helvetiae 1996 71:45-50 DOI:10.1016/0031-6865(95)00046-1 PMID:8786999
- Ribas de Pouplana, L., Frugier, M., Quinn, C. L., Schimmel, P. Evidence that two present-day components needed for the genetic code appeared after nucleated cells separated from eubacteria Proceedings of the National Academy of Sciences of the United States of America 1996 93:166-170 DOI:10.1073/pnas.93.1.166 PMID:8552597 PMCID:PMC40199
- Buechter, D. D., Schimmel, P. Minor groove recognition of the critical acceptor helix base pair by an appended module of a class II tRNA synthetase Biochemistry 1995 34:6014-6019 DOI:10.1021/bi00018a002 PMID:7742303
- Quinn, C. L., Tao, N. J., Schimmel, P. Species-specific microhelix aminoacylation by a eukaryotic pathogen tRNA synthetase dependent on a single base pair Biochemistry 1995 34:12489-12495 DOI:10.1021/bi00039a001 PMID:7547995
- Schmidt, E., Schimmel, P. Residues in a class I tRNA synthetase which determine selectivity of amino acid recognition in the context of tRNA Biochemistry 1995 34:11204-11210 DOI:10.1021/bi00035a028 PMID:7669778
- Schimmel, P., Ripmaster, T. Modular design of components of the operational RNA code for alanine in evolution Trends in Biochemical Sciences 1995 20:333-334 DOI:10.1016/s0968-0004(00)89067-2 PMID:7482695
- Shiba, K., Ripmaster, T., Suzuki, N., Nichols, R., Plotz, P., Noda, T., Schimmel, P. Human alanyl-tRNA synthetase: conservation in evolution of catalytic core and microhelix recognition Biochemistry 1995 34:10340-10349 DOI:10.1021/bi00033a004 PMID:7654687
- Hipps, D., Schimmel, P. Cell growth inhibition by sequence-specific RNA minihelices EMBO Journal 1995 14:4050-4055 PMID:7664744 PMCID:PMC394483
- Kirkpatrick, C. R., Schimmel, P. Detection of leucine-independent DNA site occupancy of the yeast Leu3p transcriptional activator in vivo Molecular and Cellular Biology 1995 15:4021-4030 PMID:7623798 PMCID:PMC230641
- Gale, A. J., Schimmel, P. Isolated RNA binding domain of a class I tRNA synthetase Biochemistry 1995 34:8896-8903 DOI:10.1021/bi00027a042 PMID:7612631
- Schimmel, P., Ribas de Pouplana, L. Transfer RNA: from minihelix to genetic code Cell 1995 81:983-986 DOI:10.1016/s0092-8674(05)80002-9 PMID:7600584
- Hipps, D., Shiba, K., Henderson, B., Schimmel, P. Operational RNA code for amino acids: species-specific aminoacylation of minihelices switched by a single nucleotide Proceedings of the National Academy of Sciences of the United States of America 1995 92:5550-5552 DOI:10.1073/pnas.92.12.5550 PMID:7539919 PMCID:PMC41733
- Ripmaster, T. L., Shiba, K., Schimmel, P. Wide cross-species aminoacyl-tRNA synthetase replacement in vivo: yeast cytoplasmic alanine enzyme replaced by human polymyositis serum antigen Proceedings of the National Academy of Sciences of the United States of America 1995 92:4932-4936 DOI:10.1073/pnas.92.11.4932 PMID:7761427 PMCID:PMC41821
- Schimmel, P. An operational RNA code for amino acids and variations in critical nucleotide sequences in evolution Journal of Molecular Evolution 1995 40:531-536 PMID:7783226
- Auld, D. S., Schimmel, P. Switching recognition of two tRNA synthetases with an amino acid swap in a designed peptide Science 1995 267:1994-1996 DOI:10.1126/science.7701322 PMID:7701322
- Musier-Forsyth, K., Shi, J. P., Henderson, B., Bald, R., Furste, J. P., Erdmann, V. A., Schimmel, P. Base-analog-induced aminoacylation of an RNA helix by a tRNA synthetase Journal of the American Chemical Society 1995 117:7253-7254 DOI:10.1021/ja00132a029
- Schimmel, P., Schmidt, E. Making connections: RNA-dependent amino acid recognition Trends in Biochemical Sciences 1995 20:1-2 DOI:10.1016/s0968-0004(00)88937-9 PMID:7878729
- Shiba, K., Schimmel, P., Motegi, H., Noda, T. Human glycyl-tRNA synthetase. Wide divergence of primary structure from bacterial counterpart and species-specific aminoacylation Journal of Biological Chemistry 1994 269:30049-30055 PMID:7962006
- Schimmel, P., Henderson, B. Possible role of aminoacyl-RNA complexes in noncoded peptide synthesis and origin of coded synthesis Proceedings of the National Academy of Sciences of the United States of America 1994 91:11283-11286 DOI:10.1073/pnas.91.24.11283 PMID:7972050 PMCID:PMC45215
- Davis, M. W., Buechter, D. D., Schimmel, P. Functional dissection of a predicted class-defining motif in a class II tRNA synthetase of unknown structure Biochemistry 1994 33:9904-9911 DOI:10.1021/bi00199a012 PMID:8060998
- Landro, J. A., Schimmel, P. Zinc-dependent cell growth conferred by mutant tRNA synthetase Journal of Biological Chemistry 1994 269:20217-20220 PMID:8051111
- Shiba, K., Suzuki, N., Shigesada, K., Namba, Y., Schimmel, P., Noda, T. Human cytoplasmic isoleucyl-tRNA synthetase: selective divergence of the anticodon-binding domain and acquisition of a new structural unit Proceedings of the National Academy of Sciences of the United States of America 1994 91:7435-7439 DOI:10.1073/pnas.91.16.7435 PMID:8052601 PMCID:PMC44415
- Schimmel, P. Areas of specialization of graduate research training grants may miss the big picture Protein Science 1994 3:995-996 DOI:10.1002/pro.5560030701 PMCID:PMC2142909
- Shi, J. P., Musier-Forsyth, K., Schimmel, P. Region of a conserved sequence motif in a class II tRNA synthetase needed for transfer of an activated amino acid to an RNA substrate Biochemistry 1994 33:5312-5318 DOI:10.1021/bi00183a039 PMID:8172905
- Schmidt, E., Schimmel, P. Mutational isolation of a sieve for editing in a transfer RNA synthetase Science 1994 264:265-267 DOI:10.1126/science.8146659 PMID:8146659
- Musier-Forsyth, K., Schimmel, P. Acceptor helix interactions in a class II tRNA synthetase: photoaffinity cross-linking of an RNA miniduplex substrate Biochemistry 1994 33:773-779 DOI:10.1021/bi00169a019 PMID:8292605
- Kim, S. H., Ribas de Pouplana, L., Schimmel, P. An RNA binding site in a tRNA synthetase with a reduced set of amino acids Biochemistry 1994 33:11040-11045 DOI:10.1021/bi00202a025 PMID:7522052
- Schimmel, P. The research university in the 21st century Chimica Oggi 1994 12:9-10
- Landro, J. A., Schmidt, E., Schimmel, P., Tierney, D. L., Pennerhahn, J. E. Thiol ligation of two zinc atoms to a class I tRNA synthetase: evidence for unshared thiols and role in amino acid binding and utilization Biochemistry 1994 33:14213-14220 DOI:10.1021/bi00251a033 PMID:7947832
- Frugier, M., Florentz, C., Schimmel, P., Giege, R. Triple aminoacylation specificity of a chimerized transfer RNA Biochemistry 1993 32:14053-14061 DOI:10.1021/bi00213a039 PMID:8268184
- Schimmel, P., Landro, J. A., Schmidt, E. Evidence for distinct locations for metal binding sites in two closely related class I tRNA synthetases Journal of Biomolecular Structure & Dynamics 1993 11:571-581 PMID:8129874
- Kim, S., Ribas de Pouplana, L., Schimmel, P. Diversified sequences of peptide epitope for same-RNA recognition Proceedings of the National Academy of Sciences of the United States of America 1993 90:10046-10050 DOI:10.1073/pnas.90.21.10046 PMID:7694278 PMCID:PMC47710
- Schimmel, P. Functional analysis suggests unexpected role for conserved active-site residue in enzyme of known structure Proceedings of the National Academy of Sciences of the United States of America 1993 90:9235-9236 DOI:10.1073/pnas.90.20.9235 PMID:8415683 PMCID:PMC47541
- Schimmel, P., Giege, R., Moras, D., Yokoyama, S. An operational RNA code for amino acids and possible relationship to genetic code Proceedings of the National Academy of Sciences of the United States of America 1993 90:8763-8768 DOI:10.1073/pnas.90.19.8763 PMID:7692438 PMCID:PMC47440
- Schimmel, P. Perception of an academic welfare state Protein Science 1993 2:1549-1550 DOI:10.1002/pro.5560021001 PMCID:PMC2142272
- Landro, J. A., Schimmel, P. Noncovalent protein assembly Current Opinion in Structural Biology 1993 3:549-554 DOI:10.1016/0959-440x(93)90082-v
- Buechter, D. D., Schimmel, P. Dissection of a class II tRNA synthetase: determinants for minihelix recognition are tightly associated with domain for amino acid activation Biochemistry 1993 32:5267-5272 DOI:10.1021/bi00070a039 PMID:8494904
- Martinis, S. A., Schimmel, P. Microhelix aminoacylation by a class I tRNA synthetase. Non-conserved base pairs required for specificity Journal of Biological Chemistry 1993 268:6069-6072 PMID:7681057
- Landro, J. A., Schimmel, P. Metal-binding site in a class I tRNA synthetase localized to a cysteine cluster inserted into nucleotide-binding fold Proceedings of the National Academy of Sciences of the United States of America 1993 90:2261-2265 DOI:10.1073/pnas.90.6.2261 PMID:8460131 PMCID:PMC46066
- Ludmerer, S. W., Wright, D. J., Schimmel, P. Purification of glutamine tRNA synthetase from Saccharomyces cerevisiae. A monomeric aminoacyl-tRNA synthetase with a large and dispensable NH2-terminal domain Journal of Biological Chemistry 1993 268:5519-5523 PMID:8449914
- Schimmel, P. GTP hydrolysis in protein synthesis: two for Tu? Science 1993 259:1264-1265 DOI:10.1126/science.8446896 PMID:8446896
- Schimmel, P. Cost of failure to project impact of protein science on human health and economy Protein Science 1993 2:139-140 DOI:10.1002/pro.5560020201 PMID:8443594 PMCID:PMC2142341
- Wright, D. J., Martinis, S. A., Jahn, M., Soll, D., Schimmel, P. Acceptor stem and anticodon RNA hairpin helix interactions with glutamine tRNA synthetase Biochimie 1993 75:1041-1049 DOI:10.1016/0300-9084(93)90003-b PMID:8199240
- Buechter, D. D., Schimmel, P. Aminoacylation of RNA minihelices: implications for tRNA synthetase structural design and evolution Critical Reviews in Biochemistry and Molecular Biology 1993 28:309-322 DOI:10.3109/10409239309078438 PMID:7691478
- Musier-Forsyth, K., Schimmel, P. Aminoacylation of RNA oligonucleotides: minimalist structures and origin of specificity FASEB Journal 1993 7:282-289 PMID:7680012
- Kim, S., Landro, J. A., Gale, A. J., Schimmel, P. C-terminal peptide appendix in a class I tRNA synthetase needed for acceptor-helix contacts and microhelix aminoacylation Biochemistry 1993 32:13026-13031 DOI:10.1021/bi00211a011 PMID:8241156
- Schmidt, E., Schimmel, P. Dominant lethality by expression of a catalytically inactive class I tRNA synthetase Proceedings of the National Academy of Sciences of the United States of America 1993 90:6919-6923 DOI:10.1073/pnas.90.15.6919 PMID:8346197 PMCID:PMC47046
- Ribas de Pouplana, L., Buechter, D. D., Davis, M. W., Schimmel, P. Idiographic representation of conserved domain of a class II tRNA synthetase of unknown structure Protein Science 1993 2:2259-2262 DOI:10.1002/pro.5560021225 PMID:8298469 PMCID:PMC2142315
- Schmidt, E., Schimmel, P. Primary structures of both subunits of Escherichia coli glycyl-tRNA synthetase Proceedings of the National Academy of Sciences of the United States of America 1993 90:6919-6923 DOI:10.1073/pnas.90.15.6919 PMID:6309809
- Shiba, K., Schimmel, P. Tripartite functional assembly of a large class I aminoacyl tRNA synthetase Journal of Biological Chemistry 1992 267:22703-22706 PMID:1429621
- Hou, Y. M., Schimmel, P. Functional compensation of a recognition-defective transfer RNA by a distal base pair substitution Biochemistry 1992 31:10310-10314 DOI:10.1021/bi00157a019 PMID:1420150
- Shepard, A., Shiba, K., Schimmel, P. RNA binding determinant in some class I tRNA synthetases identified by alignment-guided mutagenesis Proceedings of the National Academy of Sciences of the United States of America 1992 89:9964-9968 DOI:10.1073/pnas.89.20.9964 PMID:1329109 PMCID:PMC50254
- Kim, S. H., Schimmel, P. Function independence of microhelix aminoacylation from anticodon binding in a class I tRNA synthetase Journal of Biological Chemistry 1992 267:15563-15567 PMID:1639796
- Shi, J. P., Martinis, S. A., Schimmel, P. RNA tetraloops as minimalist substrates for aminoacylation Biochemistry 1992 31:4931-4936 DOI:10.1021/bi00136a002 PMID:1599917
- Francklyn, C., Musier-Forsyth, K., Schimmel, P. Small RNA helices as substrates for aminoacylation and their relationship to charging of transfer RNAs European Journal of Biochemistry 1992 206:315-321 DOI:10.1111/j.1432-1033.1992.tb16929.x PMID:1375910
- Hou, Y. M., Schimmel, P. Novel transfer RNAs that are active in Escherichia coli Biochemistry 1992 31:4157-4160 DOI:10.1021/bi00132a001 PMID:1567861
- Miller, W. T., Schimmel, P. A metal-binding motif implicated in RNA recognition by an aminoacyl-tRNA synthetase and by a retroviral gene product Molecular Microbiology 1992 6:1259-1262 DOI:10.1111/j.1365-2958.1992.tb00846.x PMID:1379318
- Burbaum, J. J., Schimmel, P. Amino acid binding by the class I aminoacyl-tRNA synthetases: role for a conserved proline in the signature sequence Protein Science 1992 1:575-581 DOI:10.1002/pro.5560010503 PMID:1304356 PMCID:PMC2142228
- Miller, W. T., Schimmel, P. A retroviral-like metal binding motif in an aminoacyl-tRNA synthetase is important for tRNA recognition Proceedings of the National Academy of Sciences of the United States of America 1992 89:2032-2035 DOI:10.1073/pnas.89.6.2032 PMID:1549561 PMCID:PMC48590
- Shiba, K., Schimmel, P. Functional assembly of a randomly cleaved protein Proceedings of the National Academy of Sciences of the United States of America 1992 89:1880-1884 DOI:10.1073/pnas.89.5.1880 PMID:1542687 PMCID:PMC48557
- Schimmel, P. Molecular biology and the transformation of protein science Protein Science 1992 1:307-308 DOI:10.1002/pro.5560010301 PMCID:PMC2142212
- Francklyn, C., Shi, J. P., Schimmel, P. Overlapping nucleotide determinants for specific aminoacylation of RNA microhelices Science 1992 255:1121-1125 DOI:10.1126/science.1546312 PMID:1546312
- Martinis, S. A., Schimmel, P. Enzymatic aminoacylation of sequence-specific RNA minihelices and hybrid duplexes with methionine Proceedings of the National Academy of Sciences of the United States of America 1992 89:65-69 DOI:10.1073/pnas.89.1.65 PMID:1729719
- Musier-Forsyth, K., Schimmel, P. Functional contacts of a transfer RNA synthetase with 2'-hydroxyl groups in the RNA minor groove Nature 1992 357:513-515 DOI:10.1038/357513a0 PMID:1608452
- Schimmel, P., Shepard, A., Shiba, K. Intron locations and functional deletions in relation to the design and evolution of a subgroup of class I tRNA synthetases Protein Science 1992 1:1387-1391 DOI:10.1002/pro.5560011018 PMID:1303756 PMCID:PMC2142098
- Schimmel, P. Mutant enzymes and dissected tRNAs that elucidate motifs for protein-RNA recognition Current Opinion in Structural Biology 1991 1:811-816 DOI:10.1016/0959-440X(91)90183-T
- Burbaum, J. J., Schimmel, P. Structural relationships and the classification of aminoacyl-tRNA synthetases Journal of Biological Chemistry 1991 266:16965-16968 PMID:1894595
- Miller, W. T., Hill, K. A. W., Schimmel, P. Evidence for a "cysteine-histidine box" metal-binding site in an Escherichia coli aminoacyl-tRNA synthetase Biochemistry 1991 30:6970-6976 DOI:10.1021/bi00242a023 PMID:1712632
- Yi, T. M., Walsh, K., Schimmel, P. Rabbit muscle creatine kinase: genomic cloning, sequencing, and analysis of upstream sequences important for expression in myocytes Nucleic Acids Research 1991 19:3027-3033 DOI:10.1093/nar/19.11.3027 PMID:2057360 PMCID:PMC328266
- Trezeguet, V., Edwards, H., Schimmel, P. A single base pair dominates over the novel identity of an Escherichia coli tyrosine tRNA in Saccharomyces cerevisiae Molecular and Cellular Biology 1991 11:2744-2751 PMID:2017176 PMCID:PMC360044
- Schimmel, P. RNA minihelices and the decoding of genetic information FASEB Journal 1991 5:2180-2187 PMID:2022314
- Shi, J. P., Schimmel, P. Aminoacylation of alanine minihelices. "Discriminator" base modulates transition state of single turnover reaction Journal of Biological Chemistry 1991 266:2705-2708 PMID:1704363
- Edwards, H., Trezeguet, V., Schimmel, P. An Escherichia coli tyrosine transfer RNA is a leucine-specific transfer RNA in the yeast Saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America 1991 88:1153-1156 DOI:10.1073/pnas.88.4.1153 PMID:1996316 PMCID:PMC50975
- Hou, Y. M., Shiba, K., Mottes, C., Schimmel, P. Sequence determination and modeling of structural motifs for the smallest monomeric aminoacyl-tRNA synthetase Proceedings of the National Academy of Sciences of the United States of America 1991 88:976-980 DOI:10.1073/pnas.88.3.976 PMID:1992490 PMCID:PMC50937
- Burbaum, J. J., Schimmel, P. Assembly of a class I tRNA synthetase from products of an artificially split gene Biochemistry 1991 30:319-324 DOI:10.1021/bi00216a002 PMID:1988033
- Schimmel, P. Classes of aminoacyl-tRNA synthetases and the establishment of the genetic code Trends in Biochemical Sciences 1991 16:1-3 DOI:10.1016/0968-0004(91)90002-d PMID:2053131
- Musier-Forsyth, K., Scaringe, S., Usman, N., Schimmel, P. Enzymatic aminoacylation of single-stranded RNA with an RNA cofactor Proceedings of the National Academy of Sciences of the United States of America 1991 88:209-213 DOI:10.1073/pnas.88.1.209 PMID:1986368 PMCID:PMC50779
- Miller, W. T., Hou, Y. M., Schimmel, P. Mutant aminoacyl-tRNA synthetase that compensates for a mutation in the major identity determinant of its tRNA Biochemistry 1991 30:2635-2641 DOI:10.1021/bi00224a011 PMID:2001352
- Musier-Forsyth, K., Usman, N., Scaringe, S., Doudna, J., Green, R., Schimmel, P. Specificity for aminoacylation of an RNA helix: an unpaired, exocyclic amino group in the minor groove Science 1991 253:784-786 DOI:10.1126/science.1876835 PMID:1876835
- Schimmel, P., Burbaum, J. J. Transfer RNA with double identity for in vitro kinetic modeling of transfer RNA identity in vivo Methods in Enzymology 1991 203:485-500 DOI:10.1016/0076-6879(91)03027-e PMID:1762569
- Francklyn, C., Schimmel, P. Enzymatic aminoacylation of an eight-base-pair microhelix with histidine Proceedings of the National Academy of Sciences of the United States of America 1990 87:8655-8659 DOI:10.1073/pnas.87.21.8655 PMID:2236077 PMCID:PMC55016
- Francklyn, C. S., Schimmel, P. Synthetic RNA molecules as substrates for enzymes that act on tRNAs and tRNA-like molecules Chemical Reviews 1990 90:1327-1342 DOI:10.1021/cr00105a013
- Schimmel, P. Hazards and their exploitation in the applications of molecular biology to structure-function relationships Biochemistry 1990 29:9495-9502 DOI:10.1021/bi00493a001 PMID:2271597
- Park, S. J., Miller, W. T., Schimmel, P. Synthetic peptide model of an essential region of an aminoacyl-tRNA synthetase Biochemistry 1990 29:9212-9218 DOI:10.1021/bi00491a015 PMID:2271589
- Chng, J. L. C., Shoemaker, D. L., Schimmel, P., Holmes, E. W. Reversal of creatine kinase translational repression by 3' untranslated sequences Science 1990 248:1003-1006 DOI:10.1126/science.2343304 PMID:2343304
- Shi, J. P., Francklyn, C., Hill, K., Schimmel, P. A nucleotide that enhances the charging of RNA minihelix sequence variants with alanine Biochemistry 1990 29:3621-3626 DOI:10.1021/bi00467a005 PMID:1692733
- Edwards, H., Schimmel, P. A bacterial amber suppressor in Saccharomyces cerevisiae is selectively recognized by a bacterial aminoacyl-tRNA synthetase Molecular and Cellular Biology 1990 10:1633-1641 PMID:1690848 PMCID:PMC362268
- Toth, M. J., Schimmel, P. A mutation in the small (alpha) subunit of glycyl-tRNA synthetase affects amino acid activation and subunit association parameters Journal of Biological Chemistry 1990 265:1005-1009 PMID:2295596
- Toth, M. J., Schimmel, P. Deletions in the large (beta) subunit of a hetero-oligomeric aminoacyl-tRNA synthetase Journal of Biological Chemistry 1990 265:1000-1004 PMID:2404005
- Schimmel, P. Alanine transfer RNA synthetase: structure-function relationships and molecular recognition of transfer RNA Advances in Enzymology and Related Areas of Molecular Biology 1990 63:233-270 PMID:2407064
- Kaddarah-Daouk, R., Lillie, J. W., Daouk, G. H., Green, M. R., Kingston, R., Schimmel, P. Induction of a cellular enzyme for energy metabolism by transforming domains of adenovirus E1a Molecular and Cellular Biology 1990 10:1476-1483 PMID:2138706 PMCID:PMC362250
- Hill, K., Schimmel, P. The dissection and engineering of sites that affect the activity of an enzyme of unknown structure Biotechnology 1990 14:65-79 PMID:2183901
- Burbaum, J. J., Starzyk, R. M., Schimmel, P. Understanding structural relationships in proteins of unsolved three-dimensional structure Proteins-Structure Function and Genetics 1990 7:99-111 DOI:10.1002/prot.340070202 PMID:2183216
- Chng, J. L. C., Mulligan, R. C., Schimmel, P., Holmes, E. W. Antisense RNA complementary to 3' coding and noncoding sequences of creatine kinase is a potent inhibitor of translation in vivo Proceedings of the National Academy of Sciences of the United States of America 1989 86:10006-10010 DOI:10.1073/pnas.86.24.10006 PMID:2481308 PMCID:PMC298631
- Starzyk, R. M., Burbaum, J. J., Schimmel, P. Insertion of new sequences into the catalytic domain of an enzyme Biochemistry 1989 28:8479-8484 DOI:10.1021/bi00447a031 PMID:2690943
- Starzyk, R. M., Schimmel, P. Construction of intra-domain chimeras of aminoacyl-tRNA synthetases Journal of Biomolecular Structure & Dynamics 1989 7:225-234 PMID:2690866
- Friden, P., Reynolds, C., Schimmel, P. A large internal deletion converts yeast LEU3 to a constitutive transcriptional activator Molecular and Cellular Biology 1989 9:4056-4060 PMID:2674686 PMCID:PMC362471
- Hou, Y. M., Schimmel, P. Evidence that a major determinant for the identity of a transfer RNA is conserved in evolution Biochemistry 1989 28:6800-6804 DOI:10.1021/bi00443a003 PMID:2684266
- Schimmel, P. RNA pseudoknots that interact with components of the translation apparatus Cell 1989 58:9-12 DOI:10.1016/0092-8674(89)90395-4 PMID:2473840
- Schimmel, P. Hazards of deducing enzyme structure-activity relationships on the basis of chemical applications of molecular biology Accounts of Chemical Research 1989 22:232-233 DOI:10.1021/ar00163a001
- Hou, Y. M., Francklyn, C., Schimmel, P. Molecular dissection of a transfer RNA and the basis for its identity Trends in Biochemical Sciences 1989 14:233-237 DOI:10.1016/0968-0004(89)90033-9 PMID:2669241
- Schimmel, P. Parameters for the molecular recognition of transfer RNAs Biochemistry 1989 28:2747-2759 DOI:10.1021/bi00433a001 PMID:2663057
- Park, S. J., Hou, Y. M., Schimmel, P. A single base pair affects binding and catalytic parameters in the molecular recognition of a transfer RNA Biochemistry 1989 28:2740-2746 DOI:10.1021/bi00432a056 PMID:2659081
- Hill, K., Schimmel, P. Evidence that the 3' end of a tRNA binds to a site in the adenylate synthesis domain of an aminoacyl-tRNA synthetase Biochemistry 1989 28:2577-2586 DOI:10.1021/bi00432a035 PMID:2543446
- Francklyn, C., Schimmel, P. Aminoacylation of RNA minihelices with alanine Nature 1989 337:478-481 DOI:10.1038/337478a0 PMID:2915692
- Hou, Y. M., Schimmel, P. Modeling with in vitro kinetic parameters for the elaboration of transfer RNA identity in vivo Biochemistry 1989 28:4942-4947 DOI:10.1021/bi00438a005 PMID:2548595
- Regan, L., Buxbaum, L., Hill, K., Schimmel, P. Rationale for engineering an enzyme by introducing a mutation that compensates for a deletion Journal of Biological Chemistry 1988 263:18598-18600 PMID:3198590
- Park, S. J., Schimmel, P. Evidence for interaction of an aminoacyl transfer RNA synthetase with a region important for the identity of its cognate transfer RNA Journal of Biological Chemistry 1988 263:16527-16530 PMID:3053691
- Frederick, C. A., Wang, A. H. J., Rich, A., Regan, L., Schimmel, P. Crystallization of a small fragment of an aminoacyl tRNA synthetase Journal of Molecular Biology 1988 203:521-522 DOI:10.1016/0022-2836(88)90019-8 PMID:3058989
- Schimmel, P. Who will watch the watchdogs? Cell 1988 54:596 DOI:10.1016/s0092-8674(88)80002-3 PMID:3409318
- Friden, P., Schimmel, P. LEU3 of Saccharomyces cerevisiae activates multiple genes for branched-chain amino acid biosynthesis by binding to a common decanucleotide core sequence Molecular and Cellular Biology 1988 8:2690-2697 PMID:3043190 PMCID:PMC363479
- Toth, M. J., Murgola, E. J., Schimmel, P. Evidence for a unique first position codon-anticodon mismatch in vivo Journal of Molecular Biology 1988 201:451-454 DOI:10.1016/0022-2836(88)90152-0 PMID:3262166
- Hou, Y. M., Schimmel, P. A simple structural feature is a major determinant of the identity of a transfer RNA Nature 1988 333:140-145 DOI:10.1038/333140a0 PMID:3285220
- Drain, P., Schimmel, P. Multiple new genes that determine activity for the first step of leucine biosynthesis in Saccharomyces cerevisiae Genetics 1988 119:13-20 PMID:3294097 PMCID:PMC1203331
- Clarke, N. D., Lien, D. C., Schimmel, P. Evidence from cassette mutagenesis for a structure-function motif in a protein of unknown structure Science 1988 240:521-523 DOI:10.1126/science.3282306 PMID:3282306
- Walsh, K., Schimmel, P. DNA-binding site for two skeletal actin promoter factors is important for expression in muscle cells Molecular and Cellular Biology 1988 8:1800-1802 PMID:3380098 PMCID:PMC363341
- Daouk, G. H., Kaddarah-Daouk, R., Putney, S., Kingston, R., Schimmel, P. Isolation of a functional human gene for brain creatine kinase Journal of Biological Chemistry 1988 263:2442-2446 PMID:2828370
- Profy, A. T., Schimmel, P. Complementary use of chemical modification and site-directed mutagenesis to probe structure activity relationships in enzymes Progress in Nucleic Acid Research and Molecular Biology 1988 35:1-26 DOI:10.1016/s0079-6603(08)60608-x PMID:3065821
- Schimmel, P. Evolution and future of biotechnology ACS Symposium Series 1988 362:30-35 DOI:10.1021/bk-1988-0362.ch003
- Schimmel, P. Third thoughts on second code Science News 1988 133:387
- Edwards, H., Schimmel, P. An E. coli aminoacyl-tRNA synthetase can substitute for yeast mitochondrial enzyme function in vivo Cell 1987 51:643-649 DOI:10.1016/0092-8674(87)90133-4 PMID:3315228
- Starzyk, R. M., Webster, T. A., Schimmel, P. Evidence for dispensable sequences inserted into a nucleotide fold Science 1987 237:1614-1618 DOI:10.1126/science.3306924 PMID:3306924
- Friden, P., Schimmel, P. LEU3 of Saccharomyces cerevisiae encodes a factor for control of RNA levels of a group of leucine-specific genes Molecular and Cellular Biology 1987 7:2708-2717 PMID:2823102 PMCID:PMC367887
- Walsh, K., Schimmel, P. Two nuclear factors compete for the skeletal muscle actin promoter Journal of Biological Chemistry 1987 262:9429-9432 PMID:3036859
- Regan, L., Bowie, J., Schimmel, P. Polypeptide sequences essential for RNA recognition by an enzyme Science 1987 235:1651-1653 DOI:10.1126/science.2435005 PMID:2435005
- Schimmel, P. Aminoacyl tRNA synthetases: general scheme of structure-function relationships in the polypeptides and recognition of transfer RNAs Annual Review of Biochemistry 1987 56:125-158 DOI:10.1146/annurev.biochem.56.1.125 PMID:3304131
- Ludmerer, S. W., Schimmel, P. Construction and analysis of deletions in the amino-terminal extension of glutamine tRNA synthetase of Saccharomyces cerevisiae Journal of Biological Chemistry 1987 262:10807-10813 PMID:3301842
- Ludmerer, S. W., Schimmel, P. Gene for yeast glutamine tRNA synthetase encodes a large amino-terminal extension and provides a strong confirmation of the signature sequence for a group of the aminoacyl-tRNA synthetases Journal of Biological Chemistry 1987 262:10801-10806 PMID:3301841
- Profy, A. T., Schimmel, P. A sulfhydryl presumed essential is not required for catalysis by an aminoacyl-tRNA synthetase Journal of Biological Chemistry 1986 261:15474-15479 PMID:3536904
- Toth, M. J., Schimmel, P. Internal structural features of E. coli glycyl-tRNA synthetase examined by subunit polypeptide chain fusions Journal of Biological Chemistry 1986 261:6643-6646 PMID:3009467
- Regan, L., Dignam, J. D., Schimmel, P. A bacterial and silkworm aminoacyl-tRNA synthetase have a common epitope which maps to the catalytic domain of each Journal of Biological Chemistry 1986 261:5241-5244 PMID:2420799
- Drain, P., Schimmel, P. Yeast LEU5 is a PET-like gene that is not essential for leucine biosynthesis Molecular and General Genetics 1986 204:397-403 DOI:10.1007/bf00331015 PMID:3020377
- Ho, C., Jasin, M., Schimmel, P. Amino-acid replacements that compensate for a large polypeptide deletion in an enzyme Science 1985 229:389-393 DOI:10.1126/science.3892692 PMID:3892692
- Ludmerer, S. W., Schimmel, P. Cloning of GLN4: an essential gene that encodes glutaminyl-tRNA synthetase in Saccharomyces cerevisiae Journal of Bacteriology 1985 163:763-768 PMID:2991203 PMCID:PMC219187
- Starzyk, R., Schoemaker, H., Schimmel, P. Covalent enzyme-RNA complex: a tRNA modification that prevents a covalent enzyme interaction also prevents aminoacylation Proceedings of the National Academy of Sciences of the United States of America 1985 82:339-342 DOI:10.1073/pnas.82.2.339 PMID:3881761 PMCID:PMC397033
- Schimmel, P. High priority scores Science 1985 229:706 DOI:10.1126/science.229.4715.706 PMID:17841480
- Schimmel, P. In biology, neither smaller nor larger is necessarily better Cell 1985 42:1 DOI:10.1016/s0092-8674(85)80090-8 PMID:4016951
- Freedman, R., Gibson, B., Donovan, D., Biemann, K., Eisenbeis, S., Parker, J., Schimmel, P. Primary structure of histidine-tRNA synthetase and characterization of hisS transcripts Journal of Biological Chemistry 1985 260:10063-10068 PMID:2991272
- Middleton, T., Herlihy, W. C., Schimmel, P. R., Munro, H. N. Synthesis and purification of oligoribonucleotides using T4 RNA ligase and reverse-phase chromatography Analytical Biochemistry 1985 144:110-117 DOI:10.1016/0003-2697(85)90091-0 PMID:3985307
- Jasin, M., Regan, L., Schimmel, P. Two mutations in the dispensable part of alanine tRNA synthetase which affect the catalytic activity Journal of Biological Chemistry 1985 260:2226-2230 PMID:3882689
- Pickering, L., Pang, H., Biemann, K., Munro, H., Schimmel, P. Two tissue-specific isozymes of creatine kinase have closely matched amino acid sequences Proceedings of the National Academy of Sciences of the United States of America 1985 82:2310-2314 DOI:10.1073/pnas.82.8.2310 PMID:3857581 PMCID:PMC397547
- Jasin, M., Schimmel, P. Deletion of an essential gene in Escherichia coli by site-specific recombination with linear DNA fragments Journal of Bacteriology 1984 159:783-786 PMID:6086588 PMCID:PMC215717
- Jasin, M., Regan, L., Schimmel, P. Dispensable pieces of an aminoacyl tRNA synthetase which activate the catalytic site Cell 1984 36:1089-1095 DOI:10.1016/0092-8674(84)90059-x PMID:6200234
- Putney, S., Herlihy, W., Royal, N., Pang, H., Aposhian, H. V., Pickering, L., Belagaje, R., Biemann, K., Page, D., Kuby, S., Schimmel, P. Rabbit muscle creatine phosphokinase. CDNA cloning, primary structure and detection of human homologues Journal of Biological Chemistry 1984 259:14317-14320 PMID:6094551
- Schimmel, P., Jasin, M., Regan, L. Size polymorphism and the structure of aminoacyl-tRNA synthetases Federation Proceedings 1984 43:2987-2990 PMID:6389183
- Webster, T., Tsai, H., Kula, M., Mackie, G. A., Schimmel, P. Specific sequence homology and three-dimensional structure of an aminoacyl transfer RNA synthetase Science 1984 226:1315-1317 DOI:10.1126/science.6390679 PMID:6390679
- Hsu, Y. P., Schimmel, P. Yeast LEU1. Repression of mRNA levels by leucine and relationship of 5'-noncoding region to that of LEU2 Journal of Biological Chemistry 1984 259:3714-3719 PMID:6323436
- Andreadis, A., Hsu, Y. P., Hermodson, M., Kohlhaw, G., Schimmel, P. Yeast LEU2. Repression of mRNA levels by leucine and primary structure of the gene product Journal of Biological Chemistry 1984 259:8059-8062 PMID:6330094
- Putney, S. D., Herlihy, W. C., Schimmel, P. A new troponin T and cDNA clones for 13 different muscle proteins, found by shotgun sequencing Nature 1983 302:718-721 DOI:10.1038/302718a0 PMID:6687628
- Schimmel, P. R. Book review: Fundamentals of Enzymology by N. C. Price and L. Stevens American Scientist 1983 71:316-317
- Jasin, M., Regan, L., Schimmel, P. Modular arrangement of functional domains along the sequence of an aminoacyl tRNA synthetase Nature 1983 306:441-447 DOI:10.1038/306441a0 PMID:6358898
- Webster, T. A., Gibson, B. W., Keng, T., Biemann, K., Schimmel, P. Primary structures of both subunits of Escherichia coli glycyl-tRNA synthetase Journal of Biological Chemistry 1983 258:637-641 PMID:6309809
- Keng, T., Schimmel, P. Synthesis of two polypeptide subunits of an aminoacyl tRNA synthetase as a single polypeptide chain Journal of Biomolecular Structure & Dynamics 1983 1:225-229 DOI:10.1080/07391102.1983.10507436 PMID:6086058
- Starzyk, R. M., Koontz, S. W., Schimmel, P. A covalent adduct between the uracil ring and the active site of an aminoacyl tRNA synthetase Nature 1982 298:136-140 DOI:10.1038/298136a0 PMID:7045689
- Keng, T., Webster, T. A., Sauer, R. T., Schimmel, P. Gene for Escherichia coli glycyl-tRNA synthetase has tandem subunit coding regions in the same reading frame Journal of Biological Chemistry 1982 257:12503-12508 PMID:6290471
- Schimmel, P., Keng, T., Putney, S. Genes for two E. coli aminoacyl tRNA synthetases Developments in Biochemistry 1982 24:49-56
- Andreadis, A., Hsu, Y. P., Kohlhaw, G. B., Schimmel, P. Nucleotide sequence of yeast LEU2 shows 5'-noncoding region has sequences cognate to leucine Cell 1982 31:319-325 DOI:10.1016/0092-8674(82)90125-8 PMID:6297759
- Schimmel, P., Putney, S., Starzyk, R. RNA and DNA sequence recognition and structure: function of aminoacyl tRNA synthetases Trends in Biochemical Sciences 1982 7:209-212 DOI:10.1016/0968-0004(82)90092-5
- Putney, S. D., Benkovic, S. J., Schimmel, P. R. A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease III and can be replicated in vivo Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 1981 78:7350-7354 DOI:10.1073/pnas.78.12.7350 PMID:6278470 PMCID:PMC349264
- Putney, S. D., Schimmel, P. An aminoacyl tRNA synthetase binds to a specific DNA sequence and regulates its gene transcription Nature 1981 291:632-635 DOI:10.1038/291632a0 PMID:6264314
- Putney, S. D., Melendez, D. L., Schimmel, P. R. Cloning, partial sequencing, and in vitro transcription of the gene for alanine tRNA synthetase Journal of Biological Chemistry 1981 256:205-211 PMID:6256345
- Freedman, R., Schimmel, P. In vitro transcription of the histidine operon. Identification of the his promoter and leader and readthrough transcripts Journal of Biological Chemistry 1981 256:10747-10750 PMID:6270128
- Putney, S. D., Royal, N. J., Devegvar, H. N., Herlihy, W. C., Biemann, K., Schimmel, P. Primary structure of a large aminoacyl-tRNA synthetase Science 1981 213:1497-1501 DOI:10.1126/science.7025207 PMID:7025207
- Putney, S. D., Sauer, R. T., Schimmel, P. R. Purification and properties of alanine tRNA synthetase from Escherichia coli. A tetramer of identical subunits Journal of Biological Chemistry 1981 256:198-204 PMID:7005211
- Schimmel, P. R. Five specific protein-transfer RNA interactions CRC Critical Reviews in Biochemistry 1980 9:207-251 DOI:10.3109/10409238009105435 PMID:6160952
- Herlihy, W. C., Royal, N. J., Biemann, K., Putney, S. D., Schimmel, P. R. Mass spectra of partial protein hydrolysates as a multiple phase check for long polypeptides deduced from DNA sequences: NH2-terminal segment of alanine tRNA synthetase Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 1980 77:6531-6535 DOI:10.1073/pnas.77.11.6531 PMID:7005898 PMCID:PMC350319
- Schimmel, P. R., Melendez, D. L., Putney, S. D. Molecular dissection of an enzyme that recognizes transfer RNA Macromolecules 1980 13:716-721 DOI:10.1021/ma60075a044
- Schimmel, P. R., Redfield, A. G. Transfer RNA in solution: selected topics Annual Review of Biophysics and Bioengineering 1980 9:181-221 DOI:10.1146/annurev.bb.09.060180.001145 PMID:6994589
- Koontz, S. W., Schimmel, P. R. Aminoacyl-tRNA synthetase-catalyzed cleavage of the glycosidic bond of 5-halogenated uridines Journal of Biological Chemistry 1979 254:12277-12280 PMID:40993
- Schimmel, P. R., Soll, D. Aminoacyl-tRNA synthetases: general features and recognition of transfer RNAs Annual Review of Biochemistry 1979 48:601-648 DOI:10.1146/annurev.bi.48.070179.003125 PMID:382994
- Schimmel, P. R., Schoemaker, H. J. Mapping the structure of specific protein-transfer RNA complexes by a tritium labeling method Methods in Enzymology 1979 59:332-350 DOI:10.1016/0076-6879(79)59095-8 PMID:440081
- Schimmel, P. R. Recent results on how aminoacyl transfer RNA synthetases recognize specific transfer RNAs Molecular and Cellular Biochemistry 1979 25:3-14 PMID:381892
- Schimmel, P. R. Understanding the recognition of transfer RNAs by aminoacyl transfer RNA synthetases Advances in Enzymology and Related Areas of Molecular Biology 1979 49:187-222 DOI:10.1002/9780470122945.ch5 PMID:400854
- Cole, F. X., Schimmel, P. R. Dynamics of tautomerization of formycin Journal of the American Chemical Society 1978 100:3957-3958 DOI:10.1021/ja00480a066
- Gamble, R. C., Schimmel, P. R. Nanosecond relaxation processes of phospholipid bilayers in transition zone Proceedings of the National Academy of Sciences of the United States of America 1978 75:3011-3014 DOI:10.1073/pnas.75.7.3011 PMID:277906 PMCID:PMC392701
- Schimmel, P. R. Approaches to understanding the mechanism of specific protein-transfer RNA interactions Accounts of Chemical Research 1977 10:411-418 DOI:10.1021/ar50119a005
- Yue, V. T., Schimmel, P. R. Direct and specific photochemical cross-linking of adenosine 5'-triphosphate to an aminoacyl-tRNA synthetase Biochemistry 1977 16:4678-4684 DOI:10.1021/bi00640a023 PMID:334247
- Schoemaker, H. J. P., Schimmel, P. R. Effect of aminoacyl transfer RNA synthetases on H-5 exchange of specific pyrimidines in transfer RNAs Biochemistry 1977 16:5454-5460 DOI:10.1021/bi00644a009 PMID:411506
- Schoemaker, H. J. P., Schimmel, P. R. Inhibition of an aminoacyl transfer RNA synthetase by a specific trinucleotide derived from the sequence of its cognate transfer RNA Biochemistry 1977 16:5461-5464 DOI:10.1021/bi00644a010 PMID:336087
- Rich, A., Schimmel, P. R. Introduction to transfer RNA Accounts of Chemical Research 1977 10:385-387 DOI:10.1021/ar50119a001
- Jekowsky, E., Schimmel, P. R., Miller, D. L. Isolation, characterization and structural implications of a nuclease-digested complex of aminoacyl transfer RNA and Escherichia coli elongation factor Tu Journal of Molecular Biology 1977 114:451-458 DOI:10.1016/0022-2836(77)90262-5 PMID:333117
- Schimmel, P. R., Budzik, G. P. Photo-cross-linking of protein-nucleic acid complexes Methods in Enzymology 1977 46:168-180 DOI:10.1016/S0076-6879(77)46018-X PMID:333226
- Rich, A., Schimmel, P. R. Structural organization of complexes of transfer RNAs with aminoacyl transfer RNA synthetases Nucleic Acids Research 1977 4:1649-1665 DOI:10.1093/nar/4.5.1649 PMID:331261 PMCID:PMC343779
- Schoemaker, H. J. P., Gamble, R. C., Budzik, G. P., Schimmel, P. R. Comparison of isotope labeling patterns of purines in three specific transfer RNAs Biochemistry 1976 15:2800-2803 DOI:10.1021/bi00658a015 PMID:779830
- Schimmel, P. R. Equilibrium and kinetic investigations of cooperative interaction of cations with transfer RNA Journal of Polymer Science Part C-Polymer Symposium 1976 387-401
- Schoemaker, H. J. P., Schimmel, P. R. Isotope labeling of free and aminoacyl transfer RNA synthetase-bound transfer RNA Journal of Biological Chemistry 1976 251:6823-6830 PMID:789377
- Gamble, R. C., Schoemaker, H. J. P., Jekowsky, E., Schimmel, P. R. Rate of tritium labeling of specific purines in relation to nucleic acid and particularly transfer RNA conformation Biochemistry 1976 15:2791-2799 DOI:10.1021/bi00658a014 PMID:949477
- Lam, S. S. M., Schimmel, P. R. Equilibrium measurements of cognate and noncognate interactions between aminoacyl transfer RNA synthetases and transfer RNA Biochemistry 1975 14:2775-2780 DOI:10.1021/bi00683a034 PMID:238575
- Schreier, A. A., Schimmel, P. R. Interaction of polyamines with fragments and whole molecules of yeast phenylalanine-specific transfer RNA Journal of Molecular Biology 1975 93:323-329 DOI:10.1016/0022-2836(75)90136-9 PMID:1097707
- Dickson, L. A., Schimmel, P. R. Structure of transfer RNA-aminoacyl transfer RNA synthetase complexes investigated by nuclease digestion Archives of Biochemistry and Biophysics 1975 167:638-645 DOI:10.1016/0003-9861(75)90507-x PMID:1092269
- Schoemaker, H. J. P., Budzik, G. P., Giege, R., Schimmel, P. R. Three photo-cross-linked complexes of yeast phenylalanine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases Journal of Biological Chemistry 1975 250:4440-4444 PMID:237899
- Budzik, G. P., Lam, S. S. M., Schoemaker, H. J. P., Schimmel, P. R. Two photo-cross-linked complexes of isoleucine specific transfer ribonucleic acid with aminoacyl transfer ribonucleic acid synthetases Journal of Biological Chemistry 1975 250:4433-4439 PMID:1095570
- Lynch, D. C., Schimmel, P. R. Cooperative binding of magnesium to transfer ribonucleic acid studied by a fluorescent probe Biochemistry 1974 13:1841-1852 DOI:10.1021/bi00706a012 PMID:4601164
- Lynch, D. C., Schimmel, P. R. Effects of abnormal base ionizations on Mg(++) binding to transfer ribonucleic acid as studied by a fluorescent probe Biochemistry 1974 13:1852-1861 DOI:10.1021/bi00706a013 PMID:4209166
- Schreier, A. A., Schimmel, P. R. Interaction of manganese with fragments, complementary fragment recombinations, and whole molecules of yeast phenylalanine specific transfer RNA Journal of Molecular Biology 1974 86:601-620 DOI:10.1016/0022-2836(74)90183-1 PMID:4604622
- Rhodes, L. M., Schimmel, P. R. Intermolecular proton-transfer reaction between base and phosphate moieties of mononucleotides in solution Journal of the American Chemical Society 1974 96:2609-2611 DOI:10.1021/ja00815a048 PMID:4833713
- Schoemaker, H. J. P., Schimmel, P. R. Photo-induced joining of a transfer RNA with its cognate aminoacyl-transfer RNA synthetase Journal of Molecular Biology 1974 84:503-513 DOI:10.1016/0022-2836(74)90112-0 PMID:4840999
- Schwartz, A. M., Schimmel, P. R. Relaxation spectra of the iron spin transition in methemoglobin Journal of Molecular Biology 1974 89:505-510 DOI:10.1016/0022-2836(74)90479-3 PMID:4374554
- Gamble, R. C., Schimmel, P. R. Transfer RNA conformation in solution investigated by isotope labeling Proceedings of the National Academy of Sciences of the United States of America 1974 71:1356-1360 PMID:4598301 PMCID:PMC388227
- Schimmel, P. R., Lynch, D. C. Interactions and conformational transitions of a transfer RNA monitored by a covalently attached fluorescent probe Polymer Preprints 1973 14:143-148
- Schimmel, P. R. Mechanism of an aminoacyl transfer ribonucleic acid synthetase Accounts of Chemical Research 1973 6:299-305 DOI:10.1021/ar50069a003
- Eldred, E. W., Schimmel, P. R. Release of aminoacyl transfer ribonucleic acid from transfer ribonucleic acid synthetase studied by rapid molecular sieve chromatography Analytical Biochemistry 1973 51:229-239 DOI:10.1016/0003-2697(73)90470-3 PMID:4347232
- Schimmel, P. R., Uhlenbeck, O. C., Lewis, J. B., Dickson, L. A., Eldred, E. W., Schreier, A. A. Binding of complementary oligonucleotides to free and aminoacyl transfer ribonucleic acid synthetase bound transfer ribonucleic acid Biochemistry 1972 11:642-646 DOI:10.1021/bi00754a028 PMID:4334910
- Lo, H. H., Schimmel, P. R. Effect of 2-3-diphosphoglycerate and ATP on ethyl isocyanide binding to human hemoglobin Biochimica et Biophysica Acta 1972 263:304-308 DOI:10.1016/0005-2795(72)90083-9 PMID:5031159
- McNeil, M. R., Schimmel, P. R. Effect of transfer ribonucleic acid on the rate law and mechanism of the adenosine triphosphate: pyrophosphate isotope exchange reaction of an aminoacyl transfer ribonucleic acid synthetase Archives of Biochemistry and Biophysics 1972 152:175-179 DOI:10.1016/0003-9861(72)90205-6 PMID:4342105
- Eldred, E. W., Schimmel, P. R. Investigation of the transfer of amino acid from a transfer ribonucleic acid synthetase-aminoacyl adenylate complex to transfer ribonucleic acid Biochemistry 1972 11:17-23 DOI:10.1021/bi00751a004 PMID:4550554
- Eldred, E. W., Schimmel, P. R. Rapid deacylation by isoleucyl transfer ribonucleic acid synthetase of isoleucine-specific transfer ribonucleic acid aminoacylated with valine Journal of Biological Chemistry 1972 247:2961-2964 PMID:4554364
- Schreier, A. A., Schimmel, P. R. Transfer ribonucleic acid synthetase catalyzed deacylation of aminoacyl transfer ribonucleic acid in the absence of adenosine monophosphate and pyrophosphate Biochemistry 1972 11:1582-1589 DOI:10.1021/bi00759a006 PMID:4337554
- Rhodes, L. M., Schimmel, P. R. Nanosecond relaxation processes in aqueous mononucleoside solutions Biochemistry 1971 10:4423-4433 PMID:5316837
- Schimmel, P. R. On the calculation of chemical relaxation amplitudes Journal of Chemical Physics 1971 54:4136-4137 DOI:10.1063/1.1675487
- Schimmel, P. R., Leung, J. G. M. Dipole moments of nonzwitterionic polypeptide chains Macromolecules 1970 3:704-705 DOI:10.1021/ma60017a617
- Cole, F. X., Schimmel, P. R. Isoleucyl transfer ribonucleic acid synthetase. The role of magnesium in amino acid activation Biochemistry 1970 9:3143-3148 DOI:10.1021/bi00818a005 PMID:4321368
- Cole, F. X., Schimmel, P. R. On the rate law and mechanism of the adenosine triphosphate-pyrophosphate isotope exchange reaction of amino acyl transfer ribonucleic acid synthetases Biochemistry 1970 9:480-489 DOI:10.1021/bi00805a005 PMID:4313472
- Lo, H. H., Schimmel, P. R. Interaction of human hemoglobin with adenine nucleotides Journal of Biological Chemistry 1969 244:5084-5086 PMID:5824580
- Kowalski, C. J., Schimmel, P. R. Interaction of lysozyme with alpha-N-acetyl-D-glucosamine Journal of Biological Chemistry 1969 244:3643-3646 PMID:5815830
- Schimmel, P. R., Flory, P. J. Conformational energies and configurational statistics of copolypeptides containing L-proline Journal of Molecular Biology 1968 34:105-120 DOI:10.1016/0022-2836(68)90237-4 PMID:5760450
- Chipman, D. M., Schimmel, P. R. Dynamics of lysozyme-saccharide interactions Journal of Biological Chemistry 1968 243:3771-3774 PMID:5658551
- Hammes, G. G., Schimmel, P. R. An investigation of water-urea and water-urea-polyethylene glycol interactions Journal of the American Chemical Society 1967 89:442-446 DOI:10.1021/ja00978a050
- Brant, D. A., Schimmel, P. R. Analysis of the skeletal configuration of crystalline hen egg-white lysozyme Proceedings of the National Academy of Sciences of the United States of America 1967 58:428-435 DOI:10.1073/pnas.58.2.428 PMID:5233451 PMCID:PMC335652
- Schimmel, P. R., Flory, P. J. Conformational energy and configurational statistics of poly-L-proline Proceedings of the National Academy of Sciences of the United States of America 1967 58:52-59 DOI:10.1073/pnas.58.1.52 PMID:5231619 PMCID:PMC335595
- Flory, P. J., Schimmel, P. R. Dipole moments in relation to configuration of polypeptide chains Journal of the American Chemical Society 1967 89:6807-6813 DOI:10.1021/ja01002a001 PMID:6064350
- Hammes, G. G., Schimmel, P. R. Relaxation spectra of enzymatic reactions Journal of Physical Chemistry 1967 71:917-923 DOI:10.1021/j100863a023 PMID:6045206
- Hammes, G. G., Schimmel, P. R. Chemical relaxation spectra: calculation of relaxation times for complex mechanisms Journal of Physical Chemistry 1966 70:2319-2324 DOI:10.1021/j100879a039
- Fasella, P., Hammes, G. G., Schimmel, P. R. A Sephadex dialysis method of determining small molecule-macromolecule binding constants Biochimica et Biophysica Acta 1965 103:708-710 DOI:10.1016/0005-2787(65)90094-8 PMID:5859855
- Hammes, G. G., Schimmel, P. R. Equilibrium measurements of the binding of cytidine 3'-phosphate to ribonuclease Journal of the American Chemical Society 1965 87:4665-4669 DOI:10.1021/ja00949a001 PMID:5844451
- Cathou, R. E., Hammes, G. G., Schimmel, P. R. Optical rotatory dispersion of ribonuclease and ribonuclease-nucleotide complexes Biochemistry 1965 4:2687-2690 DOI:10.1021/bi00888a018 PMID:4286548

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