recent publications
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academic article
- Llamosas, N., Michaelson, S. D., Vaissiere, T., Rojas, C., Miller, C. A., Rumbaugh, G. Syngap1 regulates experience-dependent cortical ensemble plasticity by promoting in vivo excitatory synapse strengthening Proceedings of the National Academy of Sciences of the United States of America 2021 118 DOI:10.1073/pnas.2100579118 PMID:34404727 PMCID:PMC8403968
- Aten, S., Kalidindi, A., Yoon, H., Rumbaugh, G., Hoyt, K. R., Obrietan, K. SynGAP is expressed in the murine suprachiasmatic nucleus and regulates circadian-gated locomotor activity and light-entrainment capacity European Journal of Neuroscience 2020 53:732-749 DOI:10.1111/ejn.15043 PMID:33174316
- Llamosas, N., Arora, V., Vij, R., Kilinc, M., Bijoch, L., Rojas, C., Reich, A., Sridharan, B., Willems, E., Piper, D. R., Scampavia, L., Spicer, T. P., et al. SYNGAP1 Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons Journal of Neuroscience 2020 40:7980-7994 DOI:10.1523/jneurosci.1367 PMID:32887745 PMCID:PMC7548701
- Chen, J. L., Zhang, P., Abe, M., Aikawa, H., Zhang, L., Frank, A. J., Zembryski, T., Hubbs, C., Park, H., Withka, J., Steppan, C., Rogers, L., et al. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing Journal of the American Chemical Society 2020 142:8706-8727 DOI:10.1021/jacs.0c00768 PMID:32364710
- Sillivan, S. E., Jamieson, S., de Nijs, L., Jones, M., Snijders, C., Klengel, T., Joseph, N. F., Krauskopf, J., Kleinjans, J., Vinkers, C. H., Boks, M. P. M., Geuze, E., et al. MicroRNA regulation of persistent stress-enhanced memory Molecular Psychiatry 2020 25:965-976 DOI:10.1038/s41380-019-0432-2 PMID:31142820 PMCID:PMC6883139
- Young, E. J., Lin, H., Kamenecka, T. M., Rumbaugh, G., Miller, C. A. Methamphetamine learning induces persistent and selective nonmuscle myosin II-dependent spine motility in the basolateral amygdala Journal of Neuroscience 2020 40:2695-2707 DOI:10.1523/jneurosci.2182-19.2020 PMID:32066582 PMCID:PMC7096141
- Gou, G., Roca-Fernandez, A., Kilinc, M., Serrano, E., Reig-Viader, R., Araki, Y., Huganir, R. L., de Quintana-Schmidt, C., Rumbaugh, G., Bayes, A. SynGAP splice variants display heterogeneous spatio-temporal expression and subcellular distribution in the developing mammalian brain Journal of Neurochemistry 2020 154:618-634 DOI:10.1111/jnc.14988 PMID:32068252
- Gripp, K. W., Schill, L., Schoyer, L., Stronach, B., Bennett, A. M., Blaser, S., Brown, A., Burdine, R., Burkitt-Wright, E., Castel, P., Darilek, S., Dias, A., et al. The sixth international RASopathies symposium: Precision medicine-From promise to practice American Journal of Medical Genetics Part A 2020 DOI:10.1002/ajmg.a.61434 PMID:31825160
- Blouin, A. M., Pisupati, S., Hoffer, C. G., Hafenbreidel, M., Jamieson, S. E., Rumbaugh, G., Miller, C. A. Social stress-potentiated methamphetamine seeking Addiction Biology 2019 24:958-968 DOI:10.1111/adb.12666 PMID:30105771 PMCID:PMC6375809
- Radnai, L., Stremel, R. F., Sellers, J. R., Rumbaugh, G., Miller, C. A. A semi-high-throughput adaptation of the NADH-coupled ATPase assay for screening small molecule inhibitors Jove-Journal of Visualized Experiments 2019 DOI:10.3791/60017 PMID:31475972
- Sridharan, B., Hubbs, C., Llamosas, N., Kilinc, M., Singhera, F. U., Willems, E., Piper, D. R., Scampavia, L., Rumbaugh, G., Spicer, T. P. A simple procedure for creating scalable phenotypic screening assays in human neurons Scientific Reports 2019 9 DOI:10.1038/s41598-019-45265-1 PMID:31227747 PMCID:PMC6588600
- Creson, T. K., Rojas, C., Hwaun, E., Vaissiere, T., Kilinc, M., Jimenez-Gomez, A., Holder, J. L., Tang, J., Colgin, L. L., Miller, C. A., Rumbaugh, G. Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior Elife 2019 8 DOI:10.7554/eLife.46752 PMID:31025938 PMCID:PMC6504227
- Sillivan, S. E., Jones, M. E., Jamieson, S., Rumbaugh, G., Miller, C. A. Bioinformatic analysis of long-lasting transcriptional and translational changes in the basolateral amygdala following acute stress PLoS One 2019 14 DOI:10.1371/journal.pone.0209846 PMID:30629705 PMCID:PMC6328204
- Michaelson, S. D., Ozkan, E. D., Aceti, M., Maity, S., Llamosas, N., Weldon, M., Mizrachi, E., Vaissiere, T., Gaffield, M. A., Christie, J. M., Holder, J. L., Miller, C. A., et al. SYNGAP1 heterozygosity disrupts sensory processing by reducing touch-related activity within somatosensory cortex circuits Nature Neuroscience 2018 21:1-13 DOI:10.1038/s41593-018-0268-0 PMID:30455457
- Kilinc, M., Creson, T., Rojas, C., Aceti, M., Ellegood, J., Vaissiere, T., Lerch, J. P., Rumbaugh, G. Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders Molecular and Cellular Neuroscience 2018 91:140-150 DOI:10.1016/j.mcn.2018.03.008 PMID:29580901 PMCID:PMC6128754
- Briggs, S. B., Hafenbreidel, M., Young, E. J., Rumbaugh, G., Miller, C. A. The role of nonmuscle myosin II in polydrug memories and memory reconsolidation Learning & Memory 2018 25:391-398 DOI:10.1101/lm.046763.117 PMID:30115760 PMCID:PMC6097765
- Wang, W., Jia, Y., Pham, D. T., Palmer, L. C., Jung, K. M., Cox, C. D., Rumbaugh, G., Piomelli, D., Gall, C. M., Lynch, G. Atypical endocannabinoid signaling initiates a new form of memory-related plasticity at a cortical input to hippocampus Cerebral Cortex 2018 28:2253-2266 DOI:10.1093/cercor/bhx126 PMID:28520937 PMCID:PMC5998949
- Weldon, M., Kilinc, M., Holder, J. L., Rumbaugh, G. The first international conference on SYNGAP1-related brain disorders: a stakeholder meeting of families, researchers, clinicians, and regulators Journal of Neurodevelopmental Disorders 2018 10 DOI:10.1186/s11689-018-9225-1 PMID:29402231 PMCID:PMC5800089
- Furth, D., Vaissiere, T., Tzortzi, O., Xuan, Y., Martin, A., Lazaridis, I., Spigolon, G., Fisone, G., Tomer, R., Deisseroth, K., Carlen, M., Miller, C. A., et al. An interactive framework for whole-brain maps at cellular resolution Nature Neuroscience 2018 21:139-149 DOI:10.1038/s41593-017-0027-7 PMID:29203898
- Sillivan, S. E., Joseph, N. F., Jamieson, S., King, M. L., Chevere-Torres, I., Fuentes, I., Shumyatsky, G. P., Brantley, A. F., Rumbaugh, G., Miller, C. A. Susceptibility and resilience to posttraumatic stress disorder-like behaviors in inbred mice Biological Psychiatry 2017 82:924-933 DOI:10.1016/j.biopsych.2017.06.030 PMID:28778658 PMCID:PMC5683920
- Young, E. J., Briggs, S. B., Rumbaugh, G., Miller, C. A. Nonmuscle myosin II inhibition disrupts methamphetamine-associated memory in females and adolescents Neurobiology of Learning and Memory 2017 139:109-116 DOI:10.1016/j.nlm.2017.01.001 PMID:28082169 PMCID:PMC5334279
- Briggs, S. B., Blouin, A. M., Young, E. J., Rumbaugh, G., Miller, C. A. Memory disrupting effects of nonmuscle myosin II inhibition depend on the class of abused drug and brain region Learning & Memory 2017 24:70-75 DOI:10.1101/lm.043976.116 PMID:28096495 PMCID:PMC5238718
- Young, E. J., Blouin, A. M., Briggs, S. B., Sillivan, S. E., Lin, L., Cameron, M. D., Rumbaugh, G., Miller, C. A. Nonmuscle myosin IIB as a therapeutic target for the prevention of relapse to methamphetamine use Molecular Psychiatry 2016 21:615-623 DOI:10.1038/mp.2015.103 PMID:26239291 PMCID:PMC4740255
- Ogden, K. K., Ozkan, E. D., Rumbaugh, G. Prioritizing the development of mouse models for childhood brain disorders Neuropharmacology 2016 100:2-16 DOI:10.1016/j.neuropharm.2015.07.029 PMID:26231830 PMCID:PMC4586073
- Rumbaugh, G., Sillivan, S. E., Ozkan, E. D., Rojas, C. S., Hubbs, C. R., Kilgore, M., Kudugunti, S., Puthanveettil, S. V., Sweatt, J. D., Rusche, J., Miller, C. A. Pharmacological selectivity within class I histone deacetylases predicts effects on synaptic function and memory rescue Neuropsychopharmacology 2015 40:2307-2316 DOI:10.1038/npp.2015.93 PMID:25837283 PMCID:PMC4538358
- Ozkan, E. D., Creson, T. K., Rojas, C. S., Hubbs, C. R., McGuire, M. N., Kakad, P. P., Miller, C. A., Rumbaugh, G. Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB Journal of Neurochemistry 2015 134:429-444 DOI:10.1111/jnc.13146 PMID:25931194 PMCID:PMC4496335
- Zhou, M., Ottenberg, G., Sferrezza, G. F., Hubbs, C., Fallahi, M., Rumbaugh, G., Brantley, A. F., Lasmezas, C. I. Neuronal death induced by misfolded prion protein is due to NAD(+) depletion and can be relieved in vitro and in vivo by NAD(+) replenishment Brain 2015 138:992-1008 DOI:10.1093/brain/awv002 PMID:25678560 PMCID:PMC4840455
- Creson, T. K., Vaissiere, T., Rojas, C., Huang, W. C., Wang, Y. X., Petralia, R. S., Page, D. T., Miller, C. A., Rumbaugh, G. Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly Biological Psychiatry 2015 77:805-815 DOI:10.1016/j.biopsych.2014.08.001 PMID:25444158 PMCID:PMC4326604
- Aguilar-Valles, A., Vaissiere, T., Griggs, E. M., Mikaelsson, M. A., Takacs, I. F., Young, E. J., Rumbaugh, G., Miller, C. A. Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation Biological Psychiatry 2014 76:57-65 DOI:10.1016/j.biopsych.2013.09.014 PMID:24183790 PMCID:PMC4024089
- Young, E. J., Griggs, E. M., Fuchs, R. A., Zigmond, Z., Rumbaugh, G., Miller, C. A. Selective, retrieval-independent disruption of methamphetamine-associated memory by actin depolymerization Biological Psychiatry 2014 75:96-104 DOI:10.1016/j.biopsych.2013.07.036 PMID:24012327 PMCID:PMC4023488
- Clement, J. P., Ozkan, E. D., Miller, C. A., Rumbaugh, G. SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity Journal of Neuroscience 2013 33:10447-10452 DOI:10.1523/jneurosci.0765-13.2013 PMID:23785156 PMCID:PMC3685838
- Griggs, E. M., Young, E. J., Rumbaugh, G., Miller, C. A. MicroRNA-182 regulates amygdala-dependent memory formation Journal of Neuroscience 2013 33:1734-1740 DOI:10.1523/jneurosci.2873-12.2013 PMID:23345246 PMCID:PMC3711533
- Lynch, G., Kramar, E. A., Babayan, A. H., Rumbaugh, G., Gall, C. M. Differences between synaptic plasticity thresholds result in new timing rules for maximizing long-term potentiation Neuropharmacology 2013 64:27-36 DOI:10.1016/j.neuropharm.2012.07.006 PMID:22820276 PMCID:PMC3445784
- Almonte, A. G., Qadri, L. H., Sultan, F. A., Watson, J. A., Mount, D. J., Rumbaugh, G., Sweatt, J. D. Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity Journal of Neurochemistry 2013 124:109-122 DOI:10.1111/jnc.12075 PMID:23113835 PMCID:PMC3518655
- Clement, J. P., Creson, T. K., Ozkan, E. D., Shi, Y. L., Reish, N. J., Almonte, A. G., Miller, B. H., Wiltgen, B. J., Miller, C. A., Xu, X., Rumbaugh, G. Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses Cell 2012 151:709-723 DOI:10.1016/j.cell.2012.08.045 PMID:23141534 PMCID:PMC3500766
- Kramar, E. A., Babayan, A. H., Gavin, C. F., Cox, C. D., Jafari, M., Gall, C. M., Rumbaugh, G., Lynch, G. Synaptic evidence for the efficacy of spaced learning Proceedings of the National Academy of Sciences of the United States of America 2012 109:5121-5126 DOI:10.1073/pnas.1120700109 PMID:22411798 PMCID:PMC3323981
- Gavin, C. F., Rubio, M. D., Young, E., Miller, C., Rumbaugh, G. Myosin II motor activity in the lateral amygdala is required for fear memory consolidation Learning & Memory 2012 19:9-14 DOI:10.1101/lm.024042.111 PMID:22174310 PMCID:PMC3246591
- Rubio, M. D., Johnson, R., Miller, C. A., Huganir, R. L., Rumbaugh, G. Regulation of synapse structure and function by distinct myosin ll motors Journal of Neuroscience 2011 31:1448-1460 DOI:10.1523/jneurosci.3294-10.2011 PMID:21273429 PMCID:PMC3074980
- Rumbaugh, G., Miller, C. A. Epigenetic changes in the brain: measuring global histone modifications Methods in Molecular Biology 2011 670:263-274 DOI:10.1007/978-1-60761-744-0_18 PMID:20967596 PMCID:PMC3235043
- Rex, C. S., Gavin, C. F., Rubio, M. D., Kramar, E. A., Chen, L. Y., Jia, Y. S., Huganir, R. L., Muzyczka, N., Gall, C. M., Miller, C. A., Lynch, G., Rumbaugh, G. Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation Neuron 2010 67:603-617 DOI:10.1016/j.neuron.2010.07.016 PMID:20797537 PMCID:PMC2929390
- Miller, C. A., Gavin, C. F., White, J. A., Parrish, R. R., Honasoge, A., Yancey, C. R., Rivera, I. M., Rubio, M. D., Rumbaugh, G., Sweatt, J. D. Cortical DNA methylation maintains remote memory Nature Neuroscience 2010 13:664-666 DOI:10.1038/nn.2560 PMID:20495557 PMCID:PMC3043549
- Kilgore, M., Miller, C. A., Fass, D. M., Hennig, K. M., Haggarty, S. J., Sweatt, J. D., Rumbaugh, G. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease Neuropsychopharmacology 2010 35:870-880 DOI:10.1038/npp.2009.197 PMID:20010553 PMCID:PMC3055373
- Funk, A. J., Rumbaugh, G., Harotunian, V., McCullumsmith, R. E., Meador-Woodruff, J. H. Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia Neuroreport 2009 20:1019-1022 DOI:10.1097/WNR.0b013e32832d30d9 PMID:19483657 PMCID:PMC3731946
- Guo, X. C., Hamilton, P. J., Reish, N. J., Sweatt, J. D., Miller, C. A., Rumbaugh, G. Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia Neuropsychopharmacology 2009 34:1659-1672 DOI:10.1038/npp.2008.223 PMID:19145222 PMCID:PMC3690772
- Heine, M., Groc, L., Frischknecht, R., Beique, J. C., Lounis, B., Rumbaugh, G., Huganir, R. L., Cognet, L., Choquet, D. Surface mobility of postsynaptic AMPARs tunes synaptic transmission Science 2008 320:201-205 DOI:10.1126/science.1152089 PMID:18403705 PMCID:PMC2715948
- Wu, Y., Arai, A. C., Rumbaugh, G., Srivastava, A. K., Turner, G., Hayashi, T., Suzuki, E., Jiang, Y. W., Zhang, L. L., Rodriguez, J., Boyle, J., Tarpey, P., et al. Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans Proceedings of the National Academy of Sciences of the United States of America 2007 104:18163-18168 DOI:10.1073/pnas.0708699104 PMID:17989220 PMCID:PMC2084314
- Sia, G. M., Beique, J. C., Rumbaugh, G., Cho, R., Worley, P. F., Huganir, R. L. Interaction of the N-terminal domain of the AMPA receptor GIuR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment Neuron 2007 55:87-102 DOI:10.1016/j.neuron.2007.06.020 PMID:17610819
- Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., Worley, P. F. Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors Neuron 2006 52:475-484 DOI:10.1016/j.neuron.2006.08.034 PMID:17088213 PMCID:PMC1764219
- Rumbaugh, G., Adams, J. P., Kim, J. H., Huganir, R. L. SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons Proceedings of the National Academy of Sciences of the United States of America 2006 103:4344-4351 DOI:10.1073/pnas.0600084103 PMID:16537406 PMCID:PMC1450173
- Thomas, G. M., Rumbaugh, G. R., Harrar, D. B., Huganir, R. L. Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission Proceedings of the National Academy of Sciences of the United States of America 2005 102:15006-15011 DOI:10.1073/pnas.0507476102 PMID:16217014 PMCID:PMC1257731
- Hayashi, T., Rumbaugh, G., Huganir, R. L. Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites Neuron 2005 47:709-723 DOI:10.1016/j.neuron.2005.06.035 PMID:16129400
- Landree, L. E., Hanlon, A. L., Strong, D. W., Rumbaugh, G., Miller, I. M., Thupari, J. N., Connolly, E. C., Huganir, R. L., Richardson, C., Witters, L. A., Kuhajda, F. P., Ronnett, G. V. C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism Journal of Biological Chemistry 2004 279:3817-3827 DOI:10.1074/jbc.M310991200 PMID:14615481
- Tao, Y. X., Rumbaugh, G., Wang, G. D., Petralia, R. S., Zhao, C. S., Kauer, F. W., Tao, F., Zhuo, M., Wenthold, R. J., Raja, S. N., Huganir, R. L., Bredt, D. S., et al. Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein Journal of Neuroscience 2003 23:6703-6712 PMID:12890763
- Rumbaugh, G., Sia, G. M., Garner, C. C., Huganir, R. L. Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons Journal of Neuroscience 2003 23:4567-4576 PMID:12805297
- Lee, H. K., Takamiya, K., Han, J. S., Man, H. Y., Kim, C. H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R. S., Wenthold, R. J., Gallagher, M., et al. Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory Cell 2003 112:631-643 DOI:10.1016/s0092-8674(03)00122-3 PMID:12628184
- Ceccon, M., Rumbaugh, G., Vicini, S. Distinct effect of pregnenolone sulfate on NMDA receptor subtypes Neuropharmacology 2001 40:491-500 DOI:10.1016/s0028-3908(00)00197-0 PMID:11249958
- Prybylowski, K., Rumbaugh, G., Wolfe, B. B., Vicini, S. Increased exon 5 expression alters extrasynaptic NMDA receptors in cerebellar neurons Journal of Neurochemistry 2000 75:1140-1146 DOI:10.1046/j.1471-4159.2000.0751140.x PMID:10936196
- Rumbaugh, G., Prybylowski, K., Wang, J. F., Vicini, S. Exon 5 and spermine regulate deactivation of NMDA receptor subtypes Journal of Neurophysiology 2000 83:1300-1306 PMID:10712457
- Rumbaugh, G., Vicini, S. Distinct synaptic and extrasynaptic NMDA receptors in developing cerebellar granule neurons Journal of Neuroscience 1999 19:10603-10610 PMID:10594044