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Rumbaugh, Gavin
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Rumbaugh, Gavin

Faculty Member
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Positions

  • 2019 - Professor, Neuroscience , Scripps Research
  • 2010 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • Postdoctoral Fellow, School of Medicine, with Dr. Richard L. Huganir, Johns Hopkins University
  • Assistant Professor, The University of Alabama at Birmingham , The University of Alabama System
  • Adjunct Assistant Professor, Department of Neurobiology, The University of Alabama at Birmingham , The University of Alabama System
  • 2012 - 2019 Associate Professor, Neuroscience , Scripps Research
  • 2010 - 2012 Assistant Professor , Neuroscience , Scripps Research
Dr. Gavin Rumbaugh studies brain mechanisms of information storage, learning, and memory with a particular emphasis on the plasticity of excitatory synapses.

Research Areas research areas

  • Alzheimer (UMLS)
  • Mental Illness (UMLS)

Contact

  • grumbaug@scripps.edu

Websites

  • Gavin Rumbaugh, Ph.D.
  • Laboratory Website
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  • Research
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Publications

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    • Chen, J. L., Zhang, P., Abe, M., Aikawa, H., Zhang, L., Frank, A. J., Zembryski, T., Hubbs, C., Park, H., Withka, J., Steppan, C., Rogers, L., et al. Design, Optimization, and Study of Small Molecules That Target Tau Pre-mRNA and Affect Splicing Journal of the American Chemical Society  2020 142:8706-8727  DOI:10.1021/jacs.0c00768  PMID:32364710
    • Sillivan, S. E., Jamieson, S., de Nijs, L., Jones, M., Snijders, C., Klengel, T., Joseph, N. F., Krauskopf, J., Kleinjans, J., Vinkers, C. H., Boks, M. P. M., Geuze, E., et al. MicroRNA regulation of persistent stress-enhanced memory Molecular Psychiatry  2020 25:965-976  DOI:10.1038/s41380-019-0432-2  PMID:31142820  PMCID:PMC6883139
    • Young, E. J., Lin, H., Kamenecka, T. M., Rumbaugh, G., Miller, C. A. Methamphetamine learning induces persistent and selective nonmuscle myosin II-dependent spine motility in the basolateral amygdala Journal of Neuroscience  2020 40:2695-2707  DOI:10.1523/jneurosci.2182-19.2020  PMID:32066582  PMCID:PMC7096141
    • Gripp, K. W., Schill, L., Schoyer, L., Stronach, B., Bennett, A. M., Blaser, S., Brown, A., Burdine, R., Burkitt-Wright, E., Castel, P., Darilek, S., Dias, A., et al. The sixth international RASopathies symposium: Precision medicine-From promise to practice American Journal of Medical Genetics Part A  2020  DOI:10.1002/ajmg.a.61434  PMID:31825160
    • Llamosas, N., Arora, V., Vij, R., Kilinc, M., Bijoch, L., Rojas, C., Reich, A., Sridharan, B., Willems, E., Piper, D. R., Scampavia, L., Spicer, T. P., et al. SYNGAP1 Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons Journal of Neuroscience  2020 40:7980-7994  DOI:10.1523/jneurosci.1367  PMID:32887745  PMCID:PMC7548701
    • Gou, G., Roca-Fernandez, A., Kilinc, M., Serrano, E., Reig-Viader, R., Araki, Y., Huganir, R. L., de Quintana-Schmidt, C., Rumbaugh, G., Bayes, A. SynGAP splice variants display heterogeneous spatio-temporal expression and subcellular distribution in the developing mammalian brain Journal of Neurochemistry  2020 154:618-634  DOI:10.1111/jnc.14988  PMID:32068252
    • Blouin, A. M., Pisupati, S., Hoffer, C. G., Hafenbreidel, M., Jamieson, S. E., Rumbaugh, G., Miller, C. A. Social stress-potentiated methamphetamine seeking Addiction Biology  2019 24:958-968  DOI:10.1111/adb.12666  PMID:30105771  PMCID:PMC6375809
    • Radnai, L., Stremel, R. F., Sellers, J. R., Rumbaugh, G., Miller, C. A. A semi-high-throughput adaptation of the NADH-coupled ATPase assay for screening small molecule inhibitors Jove-Journal of Visualized Experiments  2019  DOI:10.3791/60017  PMID:31475972
    • Sridharan, B., Hubbs, C., Llamosas, N., Kilinc, M., Singhera, F. U., Willems, E., Piper, D. R., Scampavia, L., Rumbaugh, G., Spicer, T. P. A simple procedure for creating scalable phenotypic screening assays in human neurons Scientific Reports  2019 9  DOI:10.1038/s41598-019-45265-1  PMID:31227747  PMCID:PMC6588600
    • Creson, T. K., Rojas, C., Hwaun, E., Vaissiere, T., Kilinc, M., Jimenez-Gomez, A., Holder, J. L., Tang, J., Colgin, L. L., Miller, C. A., Rumbaugh, G. Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior Elife  2019 8  DOI:10.7554/eLife.46752  PMID:31025938  PMCID:PMC6504227
    • Sillivan, S. E., Jones, M. E., Jamieson, S., Rumbaugh, G., Miller, C. A. Bioinformatic analysis of long-lasting transcriptional and translational changes in the basolateral amygdala following acute stress PLoS One  2019 14  DOI:10.1371/journal.pone.0209846  PMID:30629705  PMCID:PMC6328204
    • Michaelson, S. D., Ozkan, E. D., Aceti, M., Maity, S., Llamosas, N., Weldon, M., Mizrachi, E., Vaissiere, T., Gaffield, M. A., Christie, J. M., Holder, J. L., Miller, C. A., et al. SYNGAP1 heterozygosity disrupts sensory processing by reducing touch-related activity within somatosensory cortex circuits Nature Neuroscience  2018 21:1-13  DOI:10.1038/s41593-018-0268-0  PMID:30455457
    • Kilinc, M., Creson, T., Rojas, C., Aceti, M., Ellegood, J., Vaissiere, T., Lerch, J. P., Rumbaugh, G. Species-conserved SYNGAP1 phenotypes associated with neurodevelopmental disorders Molecular and Cellular Neuroscience  2018 91:140-150  DOI:10.1016/j.mcn.2018.03.008  PMID:29580901  PMCID:PMC6128754
    • Briggs, S. B., Hafenbreidel, M., Young, E. J., Rumbaugh, G., Miller, C. A. The role of nonmuscle myosin II in polydrug memories and memory reconsolidation Learning & Memory  2018 25:391-398  DOI:10.1101/lm.046763.117  PMID:30115760  PMCID:PMC6097765
    • Wang, W., Jia, Y., Pham, D. T., Palmer, L. C., Jung, K. M., Cox, C. D., Rumbaugh, G., Piomelli, D., Gall, C. M., Lynch, G. Atypical endocannabinoid signaling initiates a new form of memory-related plasticity at a cortical input to hippocampus Cerebral Cortex  2018 28:2253-2266  DOI:10.1093/cercor/bhx126  PMID:28520937  PMCID:PMC5998949
    • Weldon, M., Kilinc, M., Holder, J. L., Rumbaugh, G. The first international conference on SYNGAP1-related brain disorders: a stakeholder meeting of families, researchers, clinicians, and regulators Journal of Neurodevelopmental Disorders  2018 10  DOI:10.1186/s11689-018-9225-1  PMID:29402231  PMCID:PMC5800089
    • Furth, D., Vaissiere, T., Tzortzi, O., Xuan, Y., Martin, A., Lazaridis, I., Spigolon, G., Fisone, G., Tomer, R., Deisseroth, K., Carlen, M., Miller, C. A., et al. An interactive framework for whole-brain maps at cellular resolution Nature Neuroscience  2018 21:139-149  DOI:10.1038/s41593-017-0027-7  PMID:29203898
    • Sillivan, S. E., Joseph, N. F., Jamieson, S., King, M. L., Chevere-Torres, I., Fuentes, I., Shumyatsky, G. P., Brantley, A. F., Rumbaugh, G., Miller, C. A. Susceptibility and resilience to posttraumatic stress disorder-like behaviors in inbred mice Biological Psychiatry  2017 82:924-933  DOI:10.1016/j.biopsych.2017.06.030  PMID:28778658  PMCID:PMC5683920
    • Young, E. J., Briggs, S. B., Rumbaugh, G., Miller, C. A. Nonmuscle myosin II inhibition disrupts methamphetamine-associated memory in females and adolescents Neurobiology of Learning and Memory  2017 139:109-116  DOI:10.1016/j.nlm.2017.01.001  PMID:28082169  PMCID:PMC5334279
    • Briggs, S. B., Blouin, A. M., Young, E. J., Rumbaugh, G., Miller, C. A. Memory disrupting effects of nonmuscle myosin II inhibition depend on the class of abused drug and brain region Learning & Memory  2017 24:70-75  DOI:10.1101/lm.043976.116  PMID:28096495  PMCID:PMC5238718
    • Young, E. J., Blouin, A. M., Briggs, S. B., Sillivan, S. E., Lin, L., Cameron, M. D., Rumbaugh, G., Miller, C. A. Nonmuscle myosin IIB as a therapeutic target for the prevention of relapse to methamphetamine use Molecular Psychiatry  2016 21:615-623  DOI:10.1038/mp.2015.103  PMID:26239291  PMCID:PMC4740255
    • Ogden, K. K., Ozkan, E. D., Rumbaugh, G. Prioritizing the development of mouse models for childhood brain disorders Neuropharmacology  2016 100:2-16  DOI:10.1016/j.neuropharm.2015.07.029  PMID:26231830  PMCID:PMC4586073
    • Rumbaugh, G., Sillivan, S. E., Ozkan, E. D., Rojas, C. S., Hubbs, C. R., Kilgore, M., Kudugunti, S., Puthanveettil, S. V., Sweatt, J. D., Rusche, J., Miller, C. A. Pharmacological selectivity within class I histone deacetylases predicts effects on synaptic function and memory rescue Neuropsychopharmacology  2015 40:2307-2316  DOI:10.1038/npp.2015.93  PMID:25837283  PMCID:PMC4538358
    • Ozkan, E. D., Creson, T. K., Rojas, C. S., Hubbs, C. R., McGuire, M. N., Kakad, P. P., Miller, C. A., Rumbaugh, G. Input-specific regulation of hippocampal circuit maturation by non-muscle myosin IIB Journal of Neurochemistry  2015 134:429-444  DOI:10.1111/jnc.13146  PMID:25931194  PMCID:PMC4496335
    • Zhou, M., Ottenberg, G., Sferrezza, G. F., Hubbs, C., Fallahi, M., Rumbaugh, G., Brantley, A. F., Lasmezas, C. I. Neuronal death induced by misfolded prion protein is due to NAD(+) depletion and can be relieved in vitro and in vivo by NAD(+) replenishment Brain  2015 138:992-1008  DOI:10.1093/brain/awv002  PMID:25678560  PMCID:PMC4840455
    • Creson, T. K., Vaissiere, T., Rojas, C., Huang, W. C., Wang, Y. X., Petralia, R. S., Page, D. T., Miller, C. A., Rumbaugh, G. Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly Biological Psychiatry  2015 77:805-815  DOI:10.1016/j.biopsych.2014.08.001  PMID:25444158  PMCID:PMC4326604
    • Aguilar-Valles, A., Vaissiere, T., Griggs, E. M., Mikaelsson, M. A., Takacs, I. F., Young, E. J., Rumbaugh, G., Miller, C. A. Methamphetamine-associated memory is regulated by a writer and an eraser of permissive histone methylation Biological Psychiatry  2014 76:57-65  DOI:10.1016/j.biopsych.2013.09.014  PMID:24183790  PMCID:PMC4024089
    • Young, E. J., Griggs, E. M., Fuchs, R. A., Zigmond, Z., Rumbaugh, G., Miller, C. A. Selective, retrieval-independent disruption of methamphetamine-associated memory by actin depolymerization Biological Psychiatry  2014 75:96-104  DOI:10.1016/j.biopsych.2013.07.036  PMID:24012327  PMCID:PMC4023488
    • Clement, J. P., Ozkan, E. D., Miller, C. A., Rumbaugh, G. SYNGAP1 links the maturation rate of excitatory synapses to the duration of critical-period synaptic plasticity Journal of Neuroscience  2013 33:10447-10452  DOI:10.1523/jneurosci.0765-13.2013  PMID:23785156  PMCID:PMC3685838
    • Griggs, E. M., Young, E. J., Rumbaugh, G., Miller, C. A. MicroRNA-182 regulates amygdala-dependent memory formation Journal of Neuroscience  2013 33:1734-1740  DOI:10.1523/jneurosci.2873-12.2013  PMID:23345246  PMCID:PMC3711533
    • Lynch, G., Kramar, E. A., Babayan, A. H., Rumbaugh, G., Gall, C. M. Differences between synaptic plasticity thresholds result in new timing rules for maximizing long-term potentiation Neuropharmacology  2013 64:27-36  DOI:10.1016/j.neuropharm.2012.07.006  PMID:22820276  PMCID:PMC3445784
    • Almonte, A. G., Qadri, L. H., Sultan, F. A., Watson, J. A., Mount, D. J., Rumbaugh, G., Sweatt, J. D. Protease-activated receptor-1 modulates hippocampal memory formation and synaptic plasticity Journal of Neurochemistry  2013 124:109-122  DOI:10.1111/jnc.12075  PMID:23113835  PMCID:PMC3518655
    • Clement, J. P., Creson, T. K., Ozkan, E. D., Shi, Y. L., Reish, N. J., Almonte, A. G., Miller, B. H., Wiltgen, B. J., Miller, C. A., Xu, X., Rumbaugh, G. Pathogenic SYNGAP1 mutations impair cognitive development by disrupting maturation of dendritic spine synapses Cell  2012 151:709-723  DOI:10.1016/j.cell.2012.08.045  PMID:23141534  PMCID:PMC3500766
    • Kramar, E. A., Babayan, A. H., Gavin, C. F., Cox, C. D., Jafari, M., Gall, C. M., Rumbaugh, G., Lynch, G. Synaptic evidence for the efficacy of spaced learning Proceedings of the National Academy of Sciences of the United States of America  2012 109:5121-5126  DOI:10.1073/pnas.1120700109  PMID:22411798  PMCID:PMC3323981
    • Gavin, C. F., Rubio, M. D., Young, E., Miller, C., Rumbaugh, G. Myosin II motor activity in the lateral amygdala is required for fear memory consolidation Learning & Memory  2012 19:9-14  DOI:10.1101/lm.024042.111  PMID:22174310  PMCID:PMC3246591
    • Rubio, M. D., Johnson, R., Miller, C. A., Huganir, R. L., Rumbaugh, G. Regulation of synapse structure and function by distinct myosin ll motors Journal of Neuroscience  2011 31:1448-1460  DOI:10.1523/jneurosci.3294-10.2011  PMID:21273429  PMCID:PMC3074980
    • Rumbaugh, G., Miller, C. A. Epigenetic changes in the brain: measuring global histone modifications Methods in Molecular Biology  2011 670:263-274  DOI:10.1007/978-1-60761-744-0_18  PMID:20967596  PMCID:PMC3235043
    • Rex, C. S., Gavin, C. F., Rubio, M. D., Kramar, E. A., Chen, L. Y., Jia, Y. S., Huganir, R. L., Muzyczka, N., Gall, C. M., Miller, C. A., Lynch, G., Rumbaugh, G. Myosin IIb regulates actin dynamics during synaptic plasticity and memory formation Neuron  2010 67:603-617  DOI:10.1016/j.neuron.2010.07.016  PMID:20797537  PMCID:PMC2929390
    • Miller, C. A., Gavin, C. F., White, J. A., Parrish, R. R., Honasoge, A., Yancey, C. R., Rivera, I. M., Rubio, M. D., Rumbaugh, G., Sweatt, J. D. Cortical DNA methylation maintains remote memory Nature Neuroscience  2010 13:664-666  DOI:10.1038/nn.2560  PMID:20495557  PMCID:PMC3043549
    • Kilgore, M., Miller, C. A., Fass, D. M., Hennig, K. M., Haggarty, S. J., Sweatt, J. D., Rumbaugh, G. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease Neuropsychopharmacology  2010 35:870-880  DOI:10.1038/npp.2009.197  PMID:20010553  PMCID:PMC3055373
    • Funk, A. J., Rumbaugh, G., Harotunian, V., McCullumsmith, R. E., Meador-Woodruff, J. H. Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia Neuroreport  2009 20:1019-1022  DOI:10.1097/WNR.0b013e32832d30d9  PMID:19483657  PMCID:PMC3731946
    • Guo, X. C., Hamilton, P. J., Reish, N. J., Sweatt, J. D., Miller, C. A., Rumbaugh, G. Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of schizophrenia Neuropsychopharmacology  2009 34:1659-1672  DOI:10.1038/npp.2008.223  PMID:19145222  PMCID:PMC3690772
    • Heine, M., Groc, L., Frischknecht, R., Beique, J. C., Lounis, B., Rumbaugh, G., Huganir, R. L., Cognet, L., Choquet, D. Surface mobility of postsynaptic AMPARs tunes synaptic transmission Science  2008 320:201-205  DOI:10.1126/science.1152089  PMID:18403705  PMCID:PMC2715948
    • Wu, Y., Arai, A. C., Rumbaugh, G., Srivastava, A. K., Turner, G., Hayashi, T., Suzuki, E., Jiang, Y. W., Zhang, L. L., Rodriguez, J., Boyle, J., Tarpey, P., et al. Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans Proceedings of the National Academy of Sciences of the United States of America  2007 104:18163-18168  DOI:10.1073/pnas.0708699104  PMID:17989220  PMCID:PMC2084314
    • Sia, G. M., Beique, J. C., Rumbaugh, G., Cho, R., Worley, P. F., Huganir, R. L. Interaction of the N-terminal domain of the AMPA receptor GIuR4 subunit with the neuronal pentraxin NP1 mediates GluR4 synaptic recruitment Neuron  2007 55:87-102  DOI:10.1016/j.neuron.2007.06.020  PMID:17610819
    • Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., Worley, P. F. Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors Neuron  2006 52:475-484  DOI:10.1016/j.neuron.2006.08.034  PMID:17088213  PMCID:PMC1764219
    • Rumbaugh, G., Adams, J. P., Kim, J. H., Huganir, R. L. SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons Proceedings of the National Academy of Sciences of the United States of America  2006 103:4344-4351  DOI:10.1073/pnas.0600084103  PMID:16537406  PMCID:PMC1450173
    • Thomas, G. M., Rumbaugh, G. R., Harrar, D. B., Huganir, R. L. Ribosomal S6 kinase 2 interacts with and phosphorylates PDZ domain-containing proteins and regulates AMPA receptor transmission Proceedings of the National Academy of Sciences of the United States of America  2005 102:15006-15011  DOI:10.1073/pnas.0507476102  PMID:16217014  PMCID:PMC1257731
    • Hayashi, T., Rumbaugh, G., Huganir, R. L. Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites Neuron  2005 47:709-723  DOI:10.1016/j.neuron.2005.06.035  PMID:16129400
    • Landree, L. E., Hanlon, A. L., Strong, D. W., Rumbaugh, G., Miller, I. M., Thupari, J. N., Connolly, E. C., Huganir, R. L., Richardson, C., Witters, L. A., Kuhajda, F. P., Ronnett, G. V. C75, a fatty acid synthase inhibitor, modulates AMP-activated protein kinase to alter neuronal energy metabolism Journal of Biological Chemistry  2004 279:3817-3827  DOI:10.1074/jbc.M310991200  PMID:14615481
    • Tao, Y. X., Rumbaugh, G., Wang, G. D., Petralia, R. S., Zhao, C. S., Kauer, F. W., Tao, F., Zhuo, M., Wenthold, R. J., Raja, S. N., Huganir, R. L., Bredt, D. S., et al. Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein Journal of Neuroscience  2003 23:6703-6712  PMID:12890763
    • Rumbaugh, G., Sia, G. M., Garner, C. C., Huganir, R. L. Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons Journal of Neuroscience  2003 23:4567-4576  PMID:12805297
    • Lee, H. K., Takamiya, K., Han, J. S., Man, H. Y., Kim, C. H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R. S., Wenthold, R. J., Gallagher, M., et al. Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory Cell  2003 112:631-643  DOI:10.1016/s0092-8674(03)00122-3  PMID:12628184
    • Ceccon, M., Rumbaugh, G., Vicini, S. Distinct effect of pregnenolone sulfate on NMDA receptor subtypes Neuropharmacology  2001 40:491-500  DOI:10.1016/s0028-3908(00)00197-0  PMID:11249958
    • Prybylowski, K., Rumbaugh, G., Wolfe, B. B., Vicini, S. Increased exon 5 expression alters extrasynaptic NMDA receptors in cerebellar neurons Journal of Neurochemistry  2000 75:1140-1146  DOI:10.1046/j.1471-4159.2000.0751140.x  PMID:10936196
    • Rumbaugh, G., Prybylowski, K., Wang, J. F., Vicini, S. Exon 5 and spermine regulate deactivation of NMDA receptor subtypes Journal of Neurophysiology  2000 83:1300-1306  PMID:10712457
    • Rumbaugh, G., Vicini, S. Distinct synaptic and extrasynaptic NMDA receptors in developing cerebellar granule neurons Journal of Neuroscience  1999 19:10603-10610  PMID:10594044

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Research

research overview

  • The goal of my lab is to understand how synaptic proteins actively contribute to memory formation and storage. Presently, we are focused on the mechanical processes at synapses that induce structural and functional plasticity. My laboratory has recently discovered that Myosin II motor activity drives actin polymerization that stabilizes LTP and memory formation. It’s our assertion that if Myosin II/actin processes could be manipulated experimentally in a non-invasive manner, then this system could be used to improve cognition in humans with memory disorders. We are presently combining molecular-genetic, electrophysiological and biochemical analyses with rodent model systems of associative learning to understand how Myosin II motor activity at synapses regulates actin dynamics to promote information storage and memory. Our ultimate goal is to discover compounds that can restore memory in persons with Alzheimer’s disease, while also improving brain function in older people.

    Our lab also is focused on understanding how experience and genetics interact during childhood and adolescence to trigger the development of adult intellectual abilities. SynGAP, a synaptic RasGAP, regulates synapse structure and function in developing animals. Recently, it has been shown that genetic mutations in SynGAP can cause Non-Syndromic Mental Retardation (NSMR). Thus, our recently published mouse model of SynGAP dysfunction is a promising model of mental retardation, and by extension, this model could also provide a better understanding of childhood intellectual development. In these studies, we use electrophysiological and two-photon imaging methods to probe SynGAP-mediated signaling at synapses that facilitates development of brain circuits and the onset of adult cognitive modalities.

keywords

  • Ion Channels and Synaptic Function
  • Learning, Memory, and Synaptic Plasticity
  • Neurotransmitter and Neurotrophin Receptors and Cell Signaling
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Teaching

advisees

  • graduate advising relationship

    • Kilinc, Murat, Ph.D.  candidate, 2015 -
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Background

education and training

  • Ph.D. in Biophysics and Pharmacology, Georgetown University 2000
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Contact

full name

  • Gavin R. Rumbaugh

geographic location

  • Scripps Florida 

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