recent publications
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academic article
- Koizume, S., Takahashi, T., Yoshihara, M., Nakamura, Y., Ruf, W., Takenaka, K., Miyagi, E., Miyagi, Y. Cholesterol starvation and hypoxia activate the FVII gene via the SREBP1-GILZ pathway in ovarian cancer cells to produce procoagulant microvesicles Thrombosis and Haemostasis 2019 119:1058-1071 DOI:10.1055/s-0039-1687876 PMID:31055798
- Madhusudhan, T., Ruf, W. Coagulation signalling and metabolic disorders: lessons learned from animal models Hamostaseologie 2019 39:164-172 DOI:10.1055/s-0039-1688800 PMID:31132800
- Caminero, A., McCarville, J. L., Galipeau, H. J., Deraison, C., Bernier, S. P., Constante, M., Rolland, C., Meisel, M., Murray, J. A., Yu, X. B., Alaedini, A., Coombes, B. K., et al. Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2 Nature Communications 2019 10 DOI:10.1038/s41467-019-09037-9 PMID:30867416 PMCID:PMC6416356
- Rothmeier, A. S., Versteeg, H. H., Ruf, W. Factor VIIa-induced interaction with integrin controls the release of tissue factor on extracellular vesicles from endothelial cells Journal of Thrombosis and Haemostasis 2019 17:627-634 DOI:10.1111/jth.14406 PMID:30740873
- Graf, C., Wilgenbus, P., Pagel, S., Pott, J., Marini, F., Reyda, S., Kitano, M., Macher-Goppinger, S., Weiler, H., Ruf, W. Myeloid cell-synthesized coagulation factor X dampens antitumor immunity Science Immunology 2019 4 DOI:10.1126/sciimmunol.aaw8405 PMID:31541031
- Makhoul, S., Panova-Noeva, M., Regnault, V., Ruf, W., Wenzel, P., Lagrange, J. Rivaroxaban effects illustrate the underestimated importance of activated platelets in thrombin generation assessed by calibrated automated thrombography Journal of Clinical Medicine 2019 8 DOI:10.3390/jcm8111990
- Sutherland, M. R., Simon, A. Y., Shanina, I., Horwitz, M. S., Ruf, W., Pryzdial, E. L. G. Virus envelope tissue factor promotes infection in mice Journal of Thrombosis and Haemostasis 2019 17:482-491 DOI:10.1111/jth.14389 PMID:30659719 PMCID:PMC6397068
- Nguyen, T. S., Lapidot, T., Ruf, W. Extravascular coagulation in hematopoietic stem and progenitor cell regulation Blood 2018 132:123-131 DOI:10.1182/blood-2017-12-768986 PMID:29866813
- Rothmeier, A. S., Liu, E., Chakrabarty, S., Disse, J., Mueller, B. M., Ostergaard, H., Ruf, W. Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling Blood 2018 131:674-685 DOI:10.1182/blood-2017-02-768218 PMID:29246902 PMCID:PMC5805488
- Kiouptsi, K., Ruf, W., Reinhardt, C. Microbiota-derived trimethylamine the missing jigsaw piece in thrombosis? Circulation Research 2018 123:1112-1114 DOI:10.1161/circresaha.118.314039
- Ebert, J., Wilgenbus, P., Teiber, J. F., Jurk, K., Schwierczek, K., Dohrmann, M., Xia, N., Li, H., Spiecker, L., Ruf, W., Horke, S. Paraoxonase-2 regulates coagulation activation through endothelial tissue factor Blood 2018 131:2161-2172 DOI:10.1182/blood-2017-09-807040 PMID:29439952
- Ruf, W. Proteases, protease-activated receptors, and atherosclerosis Arteriosclerosis Thrombosis and Vascular Biology 2018 38:1252-1254 DOI:10.1161/atvbaha.118.311139 PMID:29793990 PMCID:PMC5976259
- Kurakula, K., Koenis, D. S., Herzik, M. A., Liu, Y. Y., Craft, J. W., van Loenen, P. B., Vos, M., Tran, M. K., Versteeg, H. H., Goumans, Mjth, Ruf, W., de Vries, C. J. M., et al. Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity Haematologica 2018 103:1073-1082 DOI:10.3324/haematol.2017.183087
- Graf, C., Ruf, W. Tissue factor as a mediator of coagulation and signaling in cancer and chronic inflammation Thrombosis Research 2018 164:S143-S147 DOI:10.1016/j.thromres.2018.01.023 PMID:29703473
- Zelaya, H., Rothmeier, A. S., Ruf, W. Tissue factor at the crossroad of coagulation and cell signaling Journal of Thrombosis and Haemostasis 2018 16:1941-1952 DOI:10.1111/jth.14246 PMID:30030891
- Yu, Y., Boing, A. N., Hau, C. M., Hajji, N., Ruf, W., Sturk, A., Nieuwland, R. Tissue factor coagulant activity is regulated by the plasma membrane microenvironment Thrombosis and Haemostasis 2018 118:990-1000 DOI:10.1055/s-0038-1642031 PMID:29679947
- Subramaniam, S., Jurk, K., Hobohm, L., Jackel, S., Saffarzadeh, M., Schwierczek, K., Wenzel, P., Langer, F., Reinhardt, C., Ruf, W. Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development Blood 2017 129:2291-2302 DOI:10.1182/blood-2016-11-74879 PMID:28223279 PMCID:PMC5399485
- Nielsen, A. L., Sorensen, A. B., Holmberg, H. L., Gandhi, P. S., Karlsson, J., Buchardt, J., Lamberth, K., Kjelgaard-Hansen, M., Ley, C. D., Sorensen, B. B., Ruf, W., Olsen, O. H., et al. Engineering of a membrane-triggered activity switch in coagulation factor VIIa Proceedings of the National Academy of Sciences of the United States of America 2017 114:12454-12459 DOI:10.1073/pnas.1618713114 PMID:29109275 PMCID:PMC5703266
- Jackel, S., Kiouptsi, K., Lillich, M., Hendrikx, T., Khandagale, A., Kollar, B., Hormann, N., Reiss, C., Subramaniam, S., Wilms, E., Ebner, K., von Bruhl, M. L., et al. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2 Blood 2017 130:542-553 DOI:10.1182/blood-2016-11-754416 PMID:28572286
- Kossmann, S., Lagrange, J., Jackel, S., Jurk, K., Ehlken, M., Schonfelder, T., Weihert, Y., Knorr, M., Brandt, M., Xia, N., Li, H., Daiber, A., et al. Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aah4923 PMID:28148841
- Kamikubo, Y., Mendolicchio, G. L., Zampolli, A., Marchese, P., Rothmeier, A. S., Orje, J. N., Gale, A. J., Krishnaswamy, S., Gruber, A., Ostergaard, H., Petersen, L. C., Ruf, W., et al. Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex Blood 2017 130:1661-1670 DOI:10.1182/blood-2017-02-767079 PMID:28729433
- Madhusudhan, T., Wang, H., Ghosh, S., Dong, W., Kumar, V., Al-Dabet, M. M., Manoharan, J., Nazir, S., Elwakiel, A., Bock, F., Kohli, S., Marquardt, A., et al. Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function Blood 2017 130:1445-1455 DOI:10.1182/blood-2017-02-767921 PMID:28687614
- Hu, Z., Cheng, J., Xu, J., Ruf, W., Lockwood, C. J. Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy Angiogenesis 2017 20:85-96 DOI:10.1007/s10456-016-9530-9 PMID:27807692 PMCID:PMC5306358
- Rothmeier, A. S., Marchese, P., Langer, F., Kamikubo, Y., Schaffner, F., Cantor, J., Ginsberg, M. H., Ruggeri, Z. M., Ruf, W. Tissue factor prothrombotic activity is regulated by integrin-arf6 trafficking Arteriosclerosis Thrombosis and Vascular Biology 2017 37:1323-1331 DOI:10.1161/atvbaha.117.309315 PMID:28495929 PMCID:PMC5501484
- Koizume, S., Ito, S., Yoshioka, Y., Kanayama, T., Nakamura, Y., Yoshihara, M., Yamada, R., Ochiya, T., Ruf, W., Miyagi, E., Hirahara, F., Miyagi, Y. High-level secretion of tissue factor-rich extracellular vesicles from ovarian cancer cells mediated by filamin-A and protease-activated receptors Thrombosis and Haemostasis 2016 115:299-310 DOI:10.1160/th15-03-0213 PMID:26446354
- Ruf, W., Rothmeier, A. S., Graf, C. Targeting clotting proteins in cancer therapy - progress and challenges Thrombosis Research 2016 140:S1-S7 PMID:27067961
- Tieken, C., Verboom, M. C., Ruf, W., Gelderblom, H., Bovee, J. V., Reitsma, P. H., Cleton-Jansen, A. M., Versteeg, H. H. Tissue factor associates with survival and regulates tumour progression in osteosarcoma Thrombosis and Haemostasis 2016 115:1025-1033 DOI:10.1160/th15-07-0541 PMID:26763081
- Rothmeier, A. S., Marchese, P., Petrich, B. G., Furlan-Freguia, C., Ginsberg, M. H., Ruggeri, Z. M., Ruf, W. Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles Journal of Clinical Investigation 2015 125:1471-1484 DOI:10.1172/jci79329 PMID:25705884
- Liang, H. P. H., Kerschen, E. J., Basu, S., Hernandez, I., Zogg, M., Jia, S., Hessner, M. J., Toso, R., Rezaie, A. R., Fernandez, J. A., Camire, R. M., Ruf, W., et al. Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice Blood 2015 126:2415-2423 DOI:10.1182/blood-2015-05-644401 PMID:26341257 PMCID:PMC4653768
- Liang, H. P. H., Kerschen, E. J., Hernandez, I., Basu, S., Zogg, M., Botros, F., Jia, S., Hessner, M. J., Griffin, J. H., Ruf, W., Weiler, H. EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice Blood 2015 125:2845-2854 DOI:10.1182/blood-2014-11-610717 PMID:25733582 PMCID:PMC4424632
- Wang, J., Chakrabarty, S., Bui, Q., Ruf, W., Samad, F. Hematopoietic tissue factor-protease-activated receptor 2 signaling promotes hepatic inflammation and contributes to pathways of gluconeogenesis and steatosis in obese mice American Journal of Pathology 2015 185:524-535 DOI:10.1016/j.ajpath.2014.10.008 PMID:25476527 PMCID:PMC4305186
- Cohen, S. G., Itkin, T., Chakrabarty, S., Graf, C., Kollet, O., Ludin, A., Golan, K., Kalinkovich, A., Ledergor, G., Wong, E., Niemeyer, E., Porat, Z., et al. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells Nature Medicine 2015 21:1307-1317 DOI:10.1038/nm.3960 PMID:26457757 PMCID:PMC4776769
- Jacobsen, C., Oechsle, K., Hauschild, J., Steinemann, G., Spath, B., Bokemeyer, C., Ruf, W., Honecker, F., Langer, F. Regulation of tissue factor in NT2 germ cell tumor cells by cisplatin chemotherapy Thrombosis Research 2015 136:673-681 DOI:10.1016/j.thromres.2015.07.002 PMID:26205155
- Tinholt, M., Stavik, B., Louch, W., Carlson, C. R., Sletten, M., Ruf, W., Skretting, G., Sandset, P. M., Iversen, N. Syndecan-3 and TFPI colocalize on the surface of endothelial-, smooth muscle-, and cancer cells PLoS One 2015 10:e0117404 DOI:10.1371/journal.pone.0117404 PMID:25617766 PMCID:PMC4305309
- Howard, B. M., Miyazawa, B. Y., Dong, W., Cedron, W. J., Vilardi, R. F., Ruf, W., Cohen, M. J. The tissue factor pathway mediates both activation of coagulation and coagulopathy after injury Journal of Trauma and Acute Care Surgery 2015 79:1009-1013 DOI:10.1097/ta.0000000000000707 PMID:26317815
- van der Meijden, P. E. J., Ozaki, Y., Ruf, W., de Laat, B., Mutch, N., Diamond, S., Nieuwland, R., Peters, T. C., Heestermans, M., Kremers, R. M. W., Moorlag, M., Boender, J., et al. Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome) Thrombosis Research 2015 136:S3-S7 DOI:10.1016/j.thromres.2015.07.034 PMID:26387733
- Ruf, W., Samad, F. Tissue factor pathways linking obesity and inflammation Hamostaseologie 2015 35:279-283 DOI:10.5482/hamo-14-11-0068 PMID:25623940 PMCID:PMC4516700
- Unruh, D., Turner, K., Srinivasan, R., Kocaturk, B., Qi, X., Chu, Z., Aronow, B. J., Plas, D. R., Gallo, C. A., Kalthoff, H., Kirchhofer, D., Ruf, W., et al. Alternatively spliced tissue factor contributes to tumor spread and activation of coagulation in pancreatic ductal adenocarcinoma International Journal of Cancer 2014 134:9-20 DOI:10.1002/ijc.28327 PMID:23754313 PMCID:PMC4122306
- Sluka, S. H. M., Akhmedov, A., Vogel, J., Unruh, D., Bogdanov, V. Y., Camici, G. G., Luscher, T. F., Ruf, W., Tanner, F. C. Alternatively spliced tissue factor is not sufficient for embryonic development PLoS One 2014 9:e97793 DOI:10.1371/journal.pone.0097793 PMID:24879059 PMCID:PMC4039448
- Yokota, N., Zarpellon, A., Chakrabarty, S., Bogdanov, V. Y., Gruber, A., Castellino, F. J., Mackman, N., Ellies, L. G., Weiler, H., Ruggeri, Z. M., Ruf, W. Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice Journal of Thrombosis and Haemostasis 2014 12:71-81 DOI:10.1111/jth.12442 PMID:24175924 PMCID:PMC3947224
- Ruf, W. FXa takes center stage in vascular inflammation Blood 2014 123:1630-1631 DOI:10.1182/blood-2014-02-553081 PMID:24627521
- Ruf, W., Schaffner, F. Role of the protein C receptor in cancer progression Thrombosis Research 2014 133:S85-S89 DOI:10.1016/S0049-3848(14)50014-X PMID:24862151 PMCID:PMC4270345
- Langer, F., Ruf, W. Synergies of phosphatidylserine and protein disulfide isomerase in tissue factor activation Thrombosis and Haemostasis 2014 111:590-597 DOI:10.1160/th13-09-0802 PMID:24452853
- Pryzdial, E. L. G., Sutherland, M. R., Ruf, W. The procoagulant envelope virus surface: contribution to enhanced infection Thrombosis Research 2014 133:S15-S17 DOI:10.1016/j.thromres.2014.03.010 PMID:24759132 PMCID:PMC4440795
- Kocaturk, B., Van den Berg, Y. W., Tiekena, C., Mieog, J. S. D., de Kruijf, E. M., Engels, C. C., van der Ent, M. A., Kuppen, P. J., Van De Velde, C. J., Ruf, W., Reitsma, P. H., Osanto, S., et al. Alternatively spliced tissue factor promotes breast cancer growth in a beta 1 integrin-dependent manner Proceedings of the National Academy of Sciences of the United States of America 2013 110:11517-11522 DOI:10.1073/pnas.1307100110 PMID:23801760 PMCID:PMC3710867
- Schaffner, F., Yokota, N., Carneiro-Lobo, T., Kitano, M., Schaffer, M., Anderson, G. M., Mueller, B. M., Esmon, C. T., Ruf, W. Endothelial protein C receptor function in murine and human breast cancer development PLoS One 2013 8:e61071 DOI:10.1371/journal.pone.0061071 PMID:23593394 PMCID:PMC3621887
- Samad, F., Ruf, W. Inflammation, obesity, and thrombosis Blood 2013 122:3415-3422 DOI:10.1182/blood-2013-05-427708 PMID:24092932 PMCID:PMC3829115
- Versteeg, H. H., Ruf, W. New helpers in TF-dependent migration Journal of Thrombosis and Haemostasis 2013 11:1877-1879 DOI:10.1111/jth.12378 PMID:23941045
- von Drygalski, A., Furlan-Freguia, C., Ruf, W., Griffin, J. H., Mosnier, L. O. Organ-specific protection against lipopolysaccharide-induced vascular leak is dependent on the endothelial protein C receptor Arteriosclerosis, Thrombosis, and Vascular Biology 2013 33:769-776 DOI:10.1161/atvbaha.112.301082 PMID:23393392
- Langer, F., Spath, B., Fischer, C., Stolz, M., Ayuk, F. A., Kroger, N., Bokemeyer, C., Ruf, W. Rapid activation of monocyte tissue factor by antithymocyte globulin is dependent on complement and protein disulfide isomerase Blood 2013 121:2324-2335 DOI:10.1182/blood-2012-10-460493 PMID:23315166 PMCID:PMC3606067
- Kanse, S. M., Declerck, P. J., Ruf, W., Broze, G., Etscheid, M. Factor vii-activating protease promotes the proteolysis and inhibition of tissue factor pathway inhibitor Arteriosclerosis, Thrombosis, and Vascular Biology 2012 32:427-433 DOI:10.1161/atvbaha.111.238394 PMID:22116096
- Koizume, S., Ito, S., Miyagi, E., Hirahara, F., Nakamura, Y., Sakuma, Y., Osaka, H., Takano, Y., Ruf, W., Miyagi, Y. Hif2 alpha-sp1 interaction mediates a deacetylation-dependent fvii-gene activation under hypoxic conditions in ovarian cancer cells Nucleic Acids Research 2012 40:5389-5401 DOI:10.1093/nar/gks201 PMID:22402494 PMCID:PMC3384323
- von Drygalski, A., Furlan-Freguia, C., Mosnier, L. O., Yegneswaran, S., Ruf, W., Griffin, J. H. Infrared fluorescence for vascular barrier breach in vivo - a novel method for quantitation of albumin efflux Thrombosis and Haemostasis 2012 108:981-991 DOI:10.1160/th12-03-0196 PMID:23052565 PMCID:PMC3597782
- Godby, R. C., van den Berg, Y. W., Srinivasan, R., Sturm, R., Hui, D. Y., Konieczny, S. F., Aronow, B. J., Ozhegov, E., Ruf, W., Versteeg, H. H., Bogdanov, V. Y. Nonproteolytic properties of murine alternatively spliced tissue factor: Implications for integrin-mediated signaling in murine models Molecular Medicine 2012 18:771-779 DOI:10.2119/molmed.2011.00416 PMID:22481268 PMCID:PMC3409277
- Rothmeier, A. S., Ruf, W. Protease-activated receptor 2 signaling in inflammation Seminars in Immunopathology 2012 34:133-149 DOI:10.1007/s00281-011-0289-1 PMID:21971685
- Gil-Bernabe, A. M., Ferjancic, S., Tlalka, M., Zhao, L., Allen, P. D., Im, J. H., Watson, K., Hill, S. A., Amirkhosravi, A., Francis, J. L., Pollard, J. W., Ruf, W., et al. Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice Blood 2012 119:3164-3175 DOI:10.1182/blood-2011-08-376426 PMID:22327225
- Ruf, W. Role of thiol pathways in tf procoagulant regulation Thrombosis Research 2012 129:S11-S12 DOI:10.1016/j.thromres.2012.02.020 PMID:22401798 PMCID:PMC3393083
- Carneiro-Lobo, T. C., Schaffner, F., Disse, J., Ostergaard, H., Francischetti, I. M. B., Monteiro, R. Q., Ruf, W. The tick-derived inhibitor ixolaris prevents tissue factor signaling on tumor cells Journal of Thrombosis and Haemostasis 2012 10:1849-1858 DOI:10.1111/j.1538-7836.2012.04864.x PMID:22823596 PMCID:PMC3433625
- Ruf, W. Tissue factor and cancer Thrombosis Research 2012 130:S84-S87 DOI:10.1016/j.thromres.2012.08.285 PMID:23026674 PMCID:PMC3882024
- Sutherland, M. R., Ruf, W., Pryzdial, E. L. G. Tissue factor and glycoprotein c on herpes simplex virus type 1 are protease-activated receptor 2 cofactors that enhance infection Blood 2012 119:3638-3645 DOI:10.1182/blood-2011-08-376814 PMID:22374699
- Reinhardt, C., Bergentall, M., Greiner, T. U., Schaffner, F., Ostergren-Lunden, G., Petersen, L. C., Ruf, W., Backhed, F. Tissue factor and par1 promote microbiota-induced intestinal vascular remodelling Nature 2012 483:627-31 DOI:10.1038/nature10893 PMID:22407318 PMCID:PMC3885420
- Schaffner, F., Yokota, N., Ruf, W. Tissue factor proangiogenic signaling in cancer progression Thrombosis Research 2012 129:S127-S131 DOI:10.1016/S0049-3848(12)70032-4 PMID:22682123
- van den Hengel, L. G., Kocaturk, B., Reitsma, P. H., Ruf, W., Versteeg, H. H. Complete abolishment of coagulant activity in monomeric disulfide-deficient tissue factor Blood 2011 118:3446-3448 PMID:21940832
- Svensson, K. J., Kucharzewska, P., Christianson, H. C., Skold, S., Lofstedt, T., Johansson, M. C., Morgelin, M., Bengzon, J., Ruf, W., Belting, M. Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and par-2-mediated heparin-binding egf signaling in endothelial cells Proceedings of the National Academy of Sciences of the United States of America 2011 108:13147-13152 DOI:10.1073/pnas.1104261108 PMID:21788507 PMCID:PMC3156184
- Valsami, S., Ruf, W., Leikauf, M. S., Madon, J., Kaech, A., Asmis, L. M. Immunomodulatory drugs increase endothelial tissue factor expression in vitro Thrombosis Research 2011 127:264-271 DOI:10.1016/j.thromres.2010.11.018 PMID:21159364
- Furlan-Freguia, C., Marchese, P., Gruber, A., Ruggeri, Z. M., Ruf, W. P2X7 receptor signaling contributes to tissue factor-dependent thrombosis in mice Journal of Clinical Investigation 2011 121:2932-2944 DOI:10.1172/jci46129 PMID:21670495 PMCID:PMC3127437
- Srinivasan, R., Ozhegov, E., Van den Berg, Y. W., Aronow, B. J., Franco, R. S., Palascak, M. B., Fallon, J. T., Ruf, W., Versteeg, H. H., Bogdanov, V. Y. Splice variants of tissue factor promote monocyte-endothelial interactions by triggering the expression of cell adhesion molecules via integrin-mediated signaling Journal of Thrombosis and Haemostasis 2011 9:2087-2096 DOI:10.1111/j.1538-7836.2011.04454.x PMID:21812913 PMCID:PMC3292430
- Disse, J., Petersen, H. H., Larsen, K. S., Persson, E., Esmon, N., Esmon, C. T., Teyton, L., Petersen, L. C., Ruf, W. The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors Journal of Biological Chemistry 2011 286:5756-5767 DOI:10.1074/jbc.M110.201228 PMID:21149441 PMCID:PMC3037688
- Versteeg, H. H., Ruf, W. Thiol pathways in the regulation of tissue factor prothrombotic activity Current Opinion in Hematology 2011 18:343-348 DOI:10.1097/MOH.0b013e32834981de PMID:21778880
- Ruf, W., Disse, J., Carneiro-Lobo, T. C., Yokota, N., Schaffner, F. Tissue factor and cell signalling in cancer progression and thrombosis Journal of Thrombosis and Haemostasis 2011 9:306-315 DOI:10.1111/j.1538-7836.2011.04318.x PMID:21781267 PMCID:PMC3151023
- Badeanlou, L., Furlan-Freguia, C., Yang, G., Ruf, W., Samad, F. Tissue factor-protease-activated receptor 2 signaling promotes diet-induced obesity and adipose inflammation Nature Medicine 2011 17:1490-1497 DOI:10.1038/nm.2461 PMID:22019885 PMCID:PMC3210891
- Schaffner, F., Versteeg, H. H., Schillert, A., Yokota, N., Petersen, L. C., Mueller, B. M., Ruf, W. Cooperation of tissue factor cytoplasmic domain and par2 signaling in breast cancer development Blood 2010 116:6106-6113 DOI:10.1182/blood-2010-06-289314 PMID:20861457 PMCID:PMC3031395
- Larsen, K. S., Ostergaard, H., Olsen, O. H., Bjelke, J. R., Ruf, W., Petersen, L. C. Engineering of substrate selectivity for tissue factor.Factor viia complex signaling through protease-activated receptor 2 Journal of Biological Chemistry 2010 285:19959-19966 DOI:10.1074/jbc.M110.101030 PMID:20388709 PMCID:PMC2888407
- Ryden, L., Grabau, D., Schaffner, F., Jonsson, P. E., Ruf, W., Belting, M. Evidence for tissue factor phosphorylation and its correlation with protease-activated receptor expression and the prognosis of primary breast cancer International Journal of Cancer 2010 126:2330-2340 DOI:10.1002/ijc.24921 PMID:19795460 PMCID:PMC2847028
- Ruf, W., Ruggeri, Z. M. Neutrophils release brakes of coagulation Nature Medicine 2010 16:851-852 DOI:10.1038/nm0810-851 PMID:20689544
- Ruf, W., Yokota, N., Schaffner, F. Tissue factor in cancer progression and angiogenesis Thrombosis Research 2010 125:S36-S38 DOI:10.1016/S0049-3848(10)70010-4 PMID:20434002 PMCID:PMC3827916
- van den Berg, Y. W., van den Hengel, L. G., Myers, H. R., Ayachi, O., Jordanova, E., Ruf, W., Spek, C. A., Reitsma, P. H., Bogdanov, V. Y., Versteeg, H. H. Alternatively spliced tissue factor induces angiogenesis through integrin ligation Proceedings of the National Academy of Sciences of the United States of America 2009 106:19497-19502 DOI:10.1073/pnas.0905325106 PMID:19875693 PMCID:PMC2780792
- Koizume, S., Yokota, N., Miyagi, E., Hirahara, F., Nakamura, Y., Sakuma, Y., Yoshida, A., Kameda, Y., Tsuchiya, E., Ruf, W., Miyagi, Y. Hepatocyte nuclear factor-4-independent synthesis of coagulation factor vii in breast cancer cells and its inhibition by targeting selective histone acetyltransferases Molecular Cancer Research 2009 7:1928-1936 DOI:10.1158/1541-7786.mcr-09-0372 PMID:19996301 PMCID:PMC2796277
- Grunewald, J., Hunt, G. S., Dong, L. Q., Niessen, F., Wen, B. G., Tsao, M. L., Perera, R., Kang, M. C., Laffitte, B. A., Azarian, S., Ruf, W., Nasoff, M., et al. Mechanistic studies of the immunochemical termination of self-tolerance with unnatural amino acids Proceedings of the National Academy of Sciences of the United States of America 2009 106:4337-4342 DOI:10.1073/pnas.0900507106 PMID:19246393 PMCID:PMC2657443
- Zhang, Q., Petersen, H. H., Ostergaard, H., Ruf, W., Olson, A. J. Molecular dynamics simulations and functional characterization of the interactions of the PAR2 ectodomain with factor VIIa Proteins-Structure Function and Bioinformatics 2009 77:559-569 DOI:10.1002/prot.22468 PMID:19536895 PMCID:PMC2913976
- Moraes, T. J., Rafii, B., Niessen, F., Suzuki, T., Martin, R., Vachon, E., Vogel, W., Ruf, W., O'Brodovich, H., Downey, G. P. Protease-activated receptor (par)1 alters bioelectric properties of distal lung epithelia without compromising barrier function Experimental Lung Research 2009 35:136-154 DOI:10.1080/01902140802490723 PMID:19263282
- Yokota, N., Koizume, S., Miyagi, E., Hirahara, F., Nakamura, Y., Kikuchi, K., Ruf, W., Sakuma, Y., Tsuchiya, E., Miyagi, Y. Self-production of tissue factor-coagulation factor vii complex by ovarian cancer cells British Journal of Cancer 2009 101:2023-2029 DOI:10.1038/sj.bjc.6605406 PMID:19904262 PMCID:PMC2795428
- Schaffner, F., Ruf, W. Tissue factor and par2 signaling in the tumor microenvironment Arteriosclerosis, Thrombosis, and Vascular Biology 2009 29:1999-2004 DOI:10.1161/atvbaha.108.177428 PMID:19661489 PMCID:PMC2806842
- Ruf, W., Furlan-Freguia, C., Niessen, F. Vascular and dendritic cell coagulation signaling in sepsis progression Journal of Thrombosis and Haemostasis 2009 7:118-121 DOI:10.1111/j.1538-7836.2009.03374.x PMID:19630782 PMCID:PMC3327479
- Weiler, H., Ruf, W. Activated protein c in sepsis: The promise of nonanticoagulant activated protein c Current Opinion in Hematology 2008 15:487-493 DOI:10.1097/MOH.0b013e32830abdf4 PMID:18695372 PMCID:PMC2742321
- Conn, E. M., Madsen, M. A., Cravatt, B. F., Ruf, W., Deryugina, E. I., Quigley, J. P. Cell surface proteomics identifies molecules functionally linked to tumor cell intravasation Journal of Biological Chemistry 2008 283:26518-26527 DOI:10.1074/jbc.M803337200 PMID:18658134 PMCID:PMC2546538
- Niessen, F., Schaffner, F., Furlan-Freguia, C., Pawlinski, R., Bhattacharjee, G., Chun, J., Derian, C. K., Andrade-Gordon, P., Rosen, H., Ruf, W. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation Nature 2008 452:654-658 DOI:10.1038/nature06663 PMID:18305483
- Bhattacharjee, G., Ahamed, J., Pawlinski, R., Liu, C., Mackman, N., Ruf, W., Edgington, T. S. Factor xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1 Circulation Research 2008 102:457-464 DOI:10.1161/circresaha.107.167759 PMID:18174463 PMCID:PMC2838720
- Gruenewald, J., Tsao, M. L., Perera, R., Dong, L. Q., Niessen, F., Wen, B. G., Kubitz, D. M., Smider, V. V., Ruf, W., Nasoff, M., Lerner, R. A., Schultz, P. G. Immunochemical termination of self-tolerance Proceedings of the National Academy of Sciences of the United States of America 2008 105:11276-11280 DOI:10.1073/pnas.0804157105 PMID:18685087 PMCID:PMC2516224
- Versteeg, H. H., Schaffner, F., Kerver, M., Petersen, H. H., Ahamed, J., Felding-Habermann, B., Takada, Y., Mueller, B. M., Ruf, W. Inhibition of tissue factor signaling suppresses tumor growth Blood 2008 111:190-199 DOI:10.1182/blood-2007-07-101048 PMID:17901245 PMCID:PMC2200804
- Redecha, P., Franzke, C. W., Ruf, W., Mackman, N., Girardi, G. Neutrophil activation by the tissue factor/factor viia/par2 axis mediates fetal death in a mouse model of anti phospholipid syndrome Journal of Clinical Investigation 2008 118:3453-3461 DOI:10.1172/jci36089 PMID:18802482 PMCID:PMC2542852
- Versteeg, H. H., Schaffner, F., Kerver, M., Ellies, L. G., Andrade-Gordon, P., Mueller, B. M., Ruf, W. Protease-activated receptor (par) 2, but not par1, signaling promotes the development of mammary adenocarcinoma in polyoma middle t mice Cancer Research 2008 68:7219-7227 DOI:10.1158/0008-5472.can-08-0419 PMID:18757438 PMCID:PMC2596617
- Moraes, T. J., Martin, R., Plumb, J. D., Vachon, E., Cameron, C. M., Danesh, A., Kelvin, D. J., Ruf, W., Downey, G. P. Role of par2 in murine pulmonary pseudomonal infection American Journal of Physiology-Lung Cellular and Molecular Physiology 2008 294:L368-L377 DOI:10.1152/ajplung.00036.2007 PMID:18083764
- Versteeg, H. H., Borensztajn, K. S., Kerver, M. E., Ruf, W., Reitsma, P. H., Spek, C. A., Peppelenbosch, M. P. Tf : Fviia-specific activation of creb upregulates proapoptotic proteins via protease-activated receptor-2 Journal of Thrombosis and Haemostasis 2008 6:1550-1557 DOI:10.1111/j.1538-7836.2008.03091.x PMID:18647225
- Schaffner, F., Ruf, W. Tissue factor and protease-activated receptor signaling in cancer Seminars in Thrombosis and Hemostasis 2008 34:147-153 DOI:10.1055/s-2008-1079254 PMID:18645919
- Ahamed, J., Niessen, F., Kurokawa, T., Lee, Y. K., Bhattacharjee, G., Morrissey, J. H., Ruf, W. Regulation of macrophage procoagulant responses by the tissue factor cytoplasmic domain in endotoxemia Blood 2007 109:5251-5259 DOI:10.1182/blood-2006-10-051334 PMID:17332247 PMCID:PMC1890821
- Uusitalo-Jarvinen, H., Kurokawa, T., Mueller, B. M., Andrade-Gordon, P., Friedlander, M., Ruf, W. Role of protease activated receptor 1 and 2 signaling in hypoxia-induced angiogenesis Arteriosclerosis, Thrombosis, and Vascular Biology 2007 27:1456-1462 DOI:10.1161/atvbaha.107.142539 PMID:17363687
- Ruf, W. Tissue factor and par signaling in tumor progression Thrombosis Research 2007 120:S7-S12 DOI:10.1016/s0049-3848(07)70125-1 PMID:18023716
- Versteeg, H. H., Ruf, W. Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity Journal of Biological Chemistry 2007 282:25416-25424 DOI:10.1074/jbc.M702410200 PMID:17613528
- Koizume, S., Jin, N. S., Miyagi, E., Hirahara, F., Nakamura, Y., Piao, J. H., Asai, A., Yoshida, A., Tsuchiya, E., Ruf, W., Miyagi, Y. Activation of cancer cell migration and invasion by ectopic synthesis of coagulation factor vii Cancer Research 2006 66:9453-9460 DOI:10.1158/0008-5472.can-06-1803 PMID:17018600
- Ahamed, J., Versteeg, H. H., Kerver, M., Chen, V. M., Mueller, B. M., Hogg, P. J., Ruf, W. Disulfide isomerization switches tissue factor from coagulation to cell signaling Proceedings of the National Academy of Sciences of the United States of America 2006 103:13932-13937 DOI:10.1073/pnas.0606411103 PMID:16959886 PMCID:PMC1599891
- Versteeg, H. H., Ruf, W. Emerging insights in tissue factor-dependent signaling events Seminars in Thrombosis and Hemostasis 2006 32:24-32 DOI:10.1055/s-2006-933337 PMID:16479459
- Chen, V. M., Ahamed, J., Versteeg, H. H., Berndt, M. C., Ruf, W., Hogg, P. J. Evidence for activation of tissue factor by an allosteric disulfide bond Biochemistry 2006 45:12020-12028 DOI:10.1021/bi061271a PMID:17002301
- Ruf, W., Mueller, B. M. Thrombin generation and the pathogenesis of cancer Seminars in Thrombosis and Hemostasis 2006 32:61-68 DOI:10.1055/s-2006-939555 PMID:16673267
- Riewald, M., Ruf, W. Protease-activated receptor-1 signaling by activated protein c in cytokine-perturbed endothelial cells is distinct from thrombin signaling Journal of Biological Chemistry 2005 280:19808-19814 DOI:10.1074/jbc.M500747200 PMID:15769747
- Ahamed, J., Belting, M., Ruf, W. Regulation of tissue factor-induced signaling by endogenous and recombinant tissue factor pathway inhibitor Blood 2005 105:2384-2391 DOI:10.1182/blood-2004-09-3422 PMID:15550483
- Bhattacharjee, G., Ahamed, J., Pedersen, B., El-Sheikh, A., Mackman, N., Ruf, W., Liu, C., Edgington, T. S. Regulation of tissue factor-mediated initiation of the coagulation cascade by cell surface grp78 Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25:1737-1743 DOI:10.1161/01.atv.0000173419.31242.56 PMID:15947236
- Belting, M., Ahamed, J., Ruf, W. Signaling of the tissue factor coagulation pathway in angiogenesis and cancer Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25:1545-1550 DOI:10.1161/01.ATV.0000171155.05809.bf PMID:15905465
- Liu, C., Dickinson, C., Shobe, J., Donate, F., Ruf, W., Edgington, T. A hybrid fibronectin motif protein as an integrin targeting selective tumor vascular thrombogen Molecular Cancer Therapeutics 2004 3:793-801 PMID:15252140
- Dorfleutner, A., Hintermann, E., Tarui, T., Takada, Y., Ruf, W. Cross-talk of integrin alpha 3 beta 1 and tissue factor in cell migration Molecular Biology of the Cell 2004 15:4416-4425 DOI:10.1091/mbc.E03-09-0640 PMID:15254262 PMCID:PMC519137
- Ruf, W. Emerging roles of tissue factor in viral hemorrhagic fever Trends in Immunology 2004 25:461-464 DOI:10.1016/j.it.2004.07.002 PMID:15324737
- Majumdar, M., Tarui, T., Shi, B. A., Akakura, N., Ruf, W., Takada, Y. Plasmin-induced migration requires signaling through protease-activated receptor 1 and integrin alpha(9)beta(1) Journal of Biological Chemistry 2004 279:37528-37534 DOI:10.1074/jbc.M401372200 PMID:15247268
- Ahamed, J., Ruf, W. Protease-activated receptor 2-dependent phosphorylation of the tissue factor cytoplasmic domain Journal of Biological Chemistry 2004 279:23038-23044 DOI:10.1074/jbc.M401376200 PMID:15039423
- Ruf, W. Protease-activated receptor signaling in the regulation of inflammation Critical Care Medicine 2004 32:S287-S292 DOI:10.1097/01.ccm.0000126364.46191.12 PMID:15118532
- Shi, X. L., Gangadharan, B., Brass, L. F., Ruf, W., Mueller, B. M. Protease-activated receptors (par1 and par2) contribute to tumor cell motility and metastasis Molecular Cancer Research 2004 2:395-402 PMID:15280447
- Belting, M., Dorrell, M. I., Sandgren, S., Aguilar, E., Ahamed, J., Dorfleutner, A., Carmeliet, P., Mueller, B. M., Friedlander, M., Ruf, W. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling Nature Medicine 2004 10:502-509 DOI:10.1038/nm1037 PMID:15098027
- Peerschke, E. I. B., Petrovan, R. J., Ghebrehiwet, B., Ruf, W. Tissue factor pathway inhibitor-2 (tfpi-2) recognizes the complement and kininogen binding protein gclqr/p33 (gclqr): Implications for vascular inflammation Thrombosis and Haemostasis 2004 92:811-819 DOI:10.1160/th04-03-0188 PMID:15467913
- Riewald, M., Petrovan, R. J., Donner, A., Ruf, W. Activated protein c signals through the thrombin receptor par1 in endothelial cells Journal of Endotoxin Research 2003 9:317-321 DOI:10.1179/096805103225002584 PMID:14577849
- Ruf, W., Seftor, E. A., Petrovan, R. J., Weiss, R. M., Gruman, L. M., Margaryan, N. V., Seftor, R. E. B., Miyagi, Y., Hendrix, M. J. C. Differential role of tissue factor pathway inhibitors 1 and 2 in melanoma vasculogenic mimicry Cancer Research 2003 63:5381-5389 PMID:14500372
- Riewald, M., Ruf, W. Proteinase-activated receptor activation by coagulation proteinases Drug Development Research 2003 59:400-407 DOI:10.1002/ddr.10310
- Dorfleutner, A., Ruf, W. Regulation of tissue factor cytoplasmic domain phosphorylation by palmitoylation Blood 2003 102:3998-4005 DOI:10.1182/blood-2003-04-1149 PMID:12920028
- Riewald, M., Ruf, W. Science review: Role of coagulation protease cascades in sepsis Critical Care 2003 7:123-129 DOI:10.1186/cc1825 PMID:12720558 PMCID:PMC270604
- Ruf, W., Dorfleutner, A., Riewald, M. Specificity of coagulation factor signaling Journal of Thrombosis and Haemostasis 2003 1:1495-1503 DOI:10.1046/j.1538-7836.2003.00300.x PMID:12871285
- Norledge, B. V., Petrovan, R. J., Ruf, W., Olson, A. J. The tissue factor/factor VIIa/factor Xa complex: a model built by docking and site-directed mutagenesis Proteins-Structure Function and Genetics 2003 53:640-648 DOI:10.1002/prot.10445 PMID:14579355
- Ruf, W., Riewald, M. Tissue factor-dependent coagulation protease signaling in acute lung injury Critical Care Medicine 2003 31:S231-S237 DOI:10.1097/01.ccm.0000057848.27456.04 PMID:12682445
- Ruf, W. Tissue factor-dependent signaling in tumor biology Pathophysiology of Haemostasis and Thrombosis 2003 33:28-30 DOI:10.1159/000073286 PMID:12954997
- Riewald, M., Petrovan, R. J., Donner, A., Mueller, B. M., Ruf, W. Activation of endothelial cell protease activated receptor 1 by the protein c pathway Science 2002 296:1880-1882 DOI:10.1126/science.1071699 PMID:12052963
- Riewald, M., Ruf, W. Orchestration of coagulation protease signaling by tissue factor Trends in Cardiovascular Medicine 2002 12:149-154 DOI:10.1016/s1050-1738(02)00153-6 PMID:12069753
- Tarui, T., Majumdar, M., Miles, L. A., Ruf, W., Takada, Y. Plasmin-induced migration of endothelial cells. A potential target for the anti-angiogenic action of angiostatin Journal of Biological Chemistry 2002 277:33564-33570 DOI:10.1074/jbc.M205514200 PMID:12087108
- Petrovan, R. J., Ruf, W. Role of zymogenicity-determining residues of coagulation factor vii/viia in cofactor interaction and macromolecular substrate recognition Biochemistry 2002 41:9302-9309 DOI:10.1021/bi0202169 PMID:12135351
- Riewald, M., Kravchenko, V. V., Petrovan, R. J., O'Brien, P. J., Brass, L. F., Ulevitch, R. J., Ruf, W. Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1 Blood 2001 97:3109-3116 DOI:10.1182/blood.V97.10.3109 PMID:11342437
- Riewald, M., Ruf, W. Mechanistic coupling of protease signaling and initiation of coagulation by tissue factor Proceedings of the National Academy of Sciences of the United States of America 2001 98:7742-7747 DOI:10.1073/pnas.141126698 PMID:11438726 PMCID:PMC35412
- Ruf, W. Molecular regulation of blood clotting in tumor biology Haemostasis 2001 31:5-7 PMID:11990479
- Petrovan, R. J., Ruf, W. Residue met(156) contributes to the labile enzyme conformation of coagulation factor viia Journal of Biological Chemistry 2001 276:6616-6620 DOI:10.1074/jbc.M004726200 PMID:11078728
- Bergum, P. W., Cruikshank, A., Maki, S. L., Kelly, C. R., Ruf, W., Vlasuk, G. P. Role of zymogen and activated factor x as scaffolds for the inhibition of the blood coagulation factor viia-tissue factor complex by recombinant nematode anticoagulant protein c2 Journal of Biological Chemistry 2001 276:10063-10071 DOI:10.1074/jbc.M009116200 PMID:11139576
- Iakhiaev, A., Ruf, W., Rao, L. V. M. The role of catalytic cleft and exosite residues of factor viia for complex formation with tissue factor pathway inhibitor Thrombosis and Haemostasis 2001 85:458-463 PMID:11307815
- Donate, F., Kelly, C. R., Ruf, W., Edgington, T. S. Dimerization of tissue factor supports solution-phase autoactivation of factor vii without influencing proteolytic activation of factor x Biochemistry 2000 39:11467-11476 DOI:10.1021/bi000986p PMID:10985793
- Ruf, W., Fischer, E. G., Huang, H. Y., Miyagi, Y., Ott, I., Riewald, M., Mueller, B. M. Diverse functions of protease receptor tissue factor in inflammation and metastasis Immunologic Research 2000 21:289-292 DOI:10.1385/ir:21:2-3:289 PMID:10852129
- Baugh, R. J., Dickinson, C. D., Ruf, W., Krishnaswamy, S. Exosite interactions determine the affinity of factor x for the extrinsic xase complex Journal of Biological Chemistry 2000 275:28826-28833 DOI:10.1074/jbc.M005266200 PMID:10889208
- Ott, I., Miyagi, Y., Miyazaki, K., Heeb, M. J., Mueller, B. M., Rao, L. V. M., Ruf, W. Reversible regulation of tissue factor-induced coagulation by glycosyl phosphatidylinositol-anchored tissue factor pathway inhibitor Arteriosclerosis, Thrombosis, and Vascular Biology 2000 20:874-882 PMID:10712416
- Petrovan, R. J., Ruf, W. Role of residue phe(225) in the cofactor-mediated, allosteric regulation of the serine protease coagulation factor viia Biochemistry 2000 39:14457-14463 DOI:10.1021/bi0009486 PMID:11087398
- Chang, Y. J., Hamaguchi, N., Chang, S. C., Ruf, W., Shen, M. C., Lin, S. W. Engineered recombinant factor vii q(217) variants with altered inhibitor specificities Biochemistry 1999 38:10940-10948 DOI:10.1021/bi990055h PMID:10460149
- Ruf, W., Shobe, J., Rao, S. M., Dickinson, C. D., Olson, A., Edgington, T. S. Importance of factor VIIa Gla-domain residue Arg-36 for recognition of the macromolecular substrate factor X Gla-domain Biochemistry 1999 38:1957-1966 DOI:10.1021/bi982254r PMID:10026279
- Shobe, J., Dickinson, C. D., Edgington, T. S., Ruf, W. Macromolecular substrate affinity for the tissue factor-factor viia complex is independent of scissile bond docking Journal of Biological Chemistry 1999 274:24171-24175 DOI:10.1074/jbc.274.34.24171 PMID:10446191
- Shobe, J., Dickinson, C. D., Ruf, W. Regulation of the catalytic function of coagulation factor viia by a conformational linkage of surface residue glu 154 to the active site Biochemistry 1999 38:2745-2751 DOI:10.1021/bi981951g PMID:10052945
- Ruf, W., Mueller, B. M. Tissue factor signaling Thrombosis and Haemostasis 1999 82:175-182 PMID:10605702
- Fischer, E. G., Riewald, M., Huang, H. Y., Miyagi, Y., Kubota, Y., Mueller, B. M., Ruf, W. Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor Journal of Clinical Investigation 1999 104:1213-1221 DOI:10.1172/jci7750 PMID:10545520
- Ott, I., Fischer, E. G., Miyagi, Y., Mueller, B. M., Ruf, W. A role for tissue factor in cell adhesion and migration mediated by interaction with actin-binding protein 280 Journal of Cell Biology 1998 140:1241-1253 DOI:10.1083/jcb.140.5.1241 PMID:9490735
- Ruf, W., Dickinson, C. D. Allosteric regulation of the cofactor dependent serine protease coagulation factor viia Trends in Cardiovascular Medicine 1998 8:350-356 DOI:10.1016/s1050-1738(98)00031-0 PMID:14987549
- Dickinson, C. D., Shobe, J., Ruf, W. Influence of cofactor binding and active site occupancy on the conformation of the macromolecular substrate exosite of factor viia Journal of Molecular Biology 1998 277:959-971 DOI:10.1006/jmbi.1998.1639 PMID:9545384
- Mueller, B. M., Ruf, W. Requirement for binding of catalytically active factor viia in tissue factor-dependent experimental metastasis Journal of Clinical Investigation 1998 101:1372-1378 DOI:10.1172/jci930 PMID:9525979
- Ruf, W. The interaction of activated factor vii with tissue factor: Insight into the mechanism of cofactor-mediated activation of activated factor vii Blood Coagulation & Fibrinolysis 1998 9:S73-S78 PMID:9819032
- Huang, M. D., Syed, R., Stura, E. A., Stone, M. J., Stefanko, R. S., Ruf, W., Edgington, T. S., Wilson, I. A. The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex Journal of Molecular Biology 1998 275:873-894 DOI:10.1006/jmbi.1997.1512 PMID:9480775
- Dickinson, C. D., Ruf, W. Active site modification of factor viia affects interactions of the protease domain with tissue factor Journal of Biological Chemistry 1997 272:19875-19879 DOI:10.1074/jbc.272.32.19875 PMID:9242651
- Kelly, C. R., Dickinson, C. D., Ruf, W. Ca2+ binding to the first epidermal growth factor module of coagulation factor viia is important for cofactor interaction and proteolytic function Journal of Biological Chemistry 1997 272:17467-17472 DOI:10.1074/jbc.272.28.17467 PMID:9211891
- Dittmar, S., Ruf, W., Edgington, T. S. Influence of mutations in tissue factor on the fine specificity of macromolecular substrate activation Biochemical Journal 1997 321:787-793 PMID:9032467 PMCID:PMC1218136
- Edgington, T. S., Dickinson, C. D., Ruf, W. The structural basis of function of the TF. VIIa complex in the cellular initiation of coagulation Thrombosis and Haemostasis 1997 78:401-405 PMID:9198187
- Stura, E. A., Ruf, W., Wilson, I. A. Crystallization and preliminary crystallographic data for a ternary complex between tissue factor, factor viia and a bpti-derived inhibitor Journal of Crystal Growth 1996 168:260-269 DOI:10.1016/0022-0248(96)00329-6
- Nicholson, A. C., Nachman, R. L., Altieri, D. C., Summers, B. D., Ruf, W., Edgington, T. S., Hajjar, D. P. Effector cell protease receptor-1 is a vascular receptor for coagulation factor xa Journal of Biological Chemistry 1996 271:28407-28413 PMID:8910465
- Dickinson, C. D., Kelly, C. R., Ruf, W. Identification of surface residues mediating tissue factor binding and catalytic function of the serine protease factor viia Proceedings of the National Academy of Sciences of the United States of America 1996 93:14379-14384 DOI:10.1073/pnas.93.25.14379 PMID:8962059
- Sevinsky, J. R., Rao, L. V. M., Ruf, W. Ligand-induced protease receptor translocation into caveolae: A mechanism for regulating cell surface proteolysis of the tissue factor-dependent coagulation pathway Journal of Cell Biology 1996 133:293-304 DOI:10.1083/jcb.133.2.293 PMID:8609163
- Kelly, C. R., Schullek, J. R., Ruf, W., Edgington, T. S. Tissue factor residue asp(44) regulates catalytic function of the bound proteinase factor vlla Biochemical Journal 1996 315:145-151 PMID:8670099 PMCID:PMC1217163
- Ruf, W., Kelly, C. R., Schullek, J. R., Martin, D. M. A., Polikarpov, I., Boys, C. W. G., Tuddenham, E. G. D., Edgington, T. S. Energetic contributions and topographical organization of ligand-binding residues of tissue factor Biochemistry 1995 34:6310-6315 DOI:10.1021/bi00019a008 PMID:7756258
- Stone, M. J., Ruf, W., Miles, D. J., Edgington, T. S., Wright, P. E. Recombinant soluble human tissue factor secreted by saccharomyces-cerevisiae and refolded from escherichia-coli inclusion-bodies - glycosylation of mutants, activity and physical characterization Biochemical Journal 1995 310:605-614 PMID:7654202 PMCID:PMC1135939
- Martin, D. M. A., Boys, C. W. G., Ruf, W. Tissue factor - molecular recognition and cofactor function FASEB Journal 1995 9:852-859 PMID:7615155
- Speidel, C. M., Eisenberg, P. R., Ruf, W., Edgington, T. S., Abendschein, D. R. Tissue factor mediates prolonged procoagulant activity on the luminal surface of balloon-injured aortas in rabbits Circulation 1995 92:3323-3330 PMID:7586321
- Rao, L. V. M., Ruf, W. Tissue factor residues lys(165) and lys(166) are essential for rapid formation of the quaternary complex of tissue-factor-center-dot-viia with xa-center-dot-tissue factor pathway inhibitor Biochemistry 1995 34:10867-10871 DOI:10.1021/bi00034a020 PMID:7662667
- Fischer, E. G., Ruf, W., Mueller, B. M. Tissue factor-initiated thrombin generation activates the signaling thrombin receptor on malignant-melanoma cells Cancer Research 1995 55:1629-1632 PMID:7712465
- Ruf, W. Factor viia residue arg(290) is required for efficient activation of the macromolecular substrate factor-x Biochemistry 1994 33:11631-11636 DOI:10.1021/bi00204a026 PMID:7918377
- Schullek, J. R., Ruf, W., Edgington, T. S. Key ligand interface residues in tissue factor contribute independently to factor viia binding Journal of Biological Chemistry 1994 269:19399-19403 PMID:8034706
- Ruf, W., Schullek, J. R., Stone, M. J., Edgington, T. S. Mutational mapping of functional residues in tissue factor - identification of factor-vii recognition determinants in both structural modules of the predicted cytokine receptor homology domain Biochemistry 1994 33:1565-1572 DOI:10.1021/bi00172a037 PMID:8312277
- Ruf, W., Edgington, T. S. Structural biology of tissue factor, the initiator of thrombogenesis in vivo FASEB Journal 1994 8:385-390 PMID:8168689
- Ihnken, K., Speiser, W., Ruf, W., Thiel, W., Schlepper, M., Mullerberghaus, G. High pai activity with correlation to triglyceride and hdl cholesterol values in patients with coronary-artery disease with no difference in survivors of myocardial-infarction Annals of Hematology 1993 67:237-244 DOI:10.1007/bf01715054 PMID:8241347
- Ruf, W., Rehemtulla, A., Edgington, T. S. Mutational analysis of receptor and cofactor function of tissue factor Methods in Enzymology 1993 222:209-224 PMID:8412795
- Ruf, W., Rehemtulla, A., Edgington, T. S. Mutational analysis of receptor and cofactor function of tissue factor Proteolytic Enzymes in Coagulation, Fibrinolysis, and Complement Activation, Part A 1993 222:209-224 PMID:8412795
- Edgington, T. S., Mackman, N., Fan, S. T., Ruf, W. Cellular immune and cytokine pathways resulting in tissue factor expression and relevance to septic shock Nouvelle Revue Francaise d Hematologie 1992 34:S15-S27 PMID:1364116
- Ruf, W., Miles, D. J., Rehemtulla, A., Edgington, T. S. Cofactor residues lysine-165 and lysine-166 are critical for protein substrate recognition by the tissue factor-factor-viia protease complex Journal of Biological Chemistry 1992 267:6375-6381 PMID:1372908
- Mueller, B. M., Reisfeld, R. A., Edgington, T. S., Ruf, W. Expression of tissue factor by melanoma-cells promotes efficient hematogenous metastasis Proceedings of the National Academy of Sciences of the United States of America 1992 89:11832-11836 DOI:10.1073/pnas.89.24.11832 PMID:1465406
- Ruf, W., Stura, E. A., Lapolla, R. J., Syed, R., Edgington, T. S., Wilson, I. A. Purification, sequence and crystallization of an antitissue factor fab and its use for the crystallization of tissue factor Journal of Crystal Growth 1992 122:253-264 DOI:10.1016/0022-0248(92)90254-g
- Rehemtulla, A., Ruf, W., Miles, D. J., Edgington, T. S. The third Trp-Lys-Ser (WKS) tripeptide motif in tissue factor is associated with a function site Biochemical Journal 1992 282:737-740 PMID:1554354 PMCID:PMC1130849
- Ruf, W., Miles, D. J., Rehemtulla, A., Edgington, T. S. Tissue factor residues 157-167 are required for efficient proteolytic activation of factor-x and factor-vii Journal of Biological Chemistry 1992 267:22206-22210 PMID:1429572
- Ruf, W., Edgington, T. S. An antitissue factor monoclonal-antibody which inhibits tf-viia complex is a potent anticoagulant in plasma Thrombosis and Haemostasis 1991 66:529-533 PMID:1803616
- Ruf, W., Rehemtulla, A., Edgington, T. S. Antibody mapping of tissue factor implicates 2 different exon-encoded regions in function Biochemical Journal 1991 278:729-733 PMID:1716883 PMCID:PMC1151407
- Ruf, W., Kalnik, M. W., Lundhansen, T., Edgington, T. S. Characterization of factor-vii association with tissue factor in solution - high and low affinity calcium-binding sites in factor-vii contribute to functionally distinct interactions Journal of Biological Chemistry 1991 266:15719-15725 PMID:1874730
- Taylor, F. B., Chang, A., Ruf, W., Morrissey, J. H., Hinshaw, L., Catlett, R., Blick, K., Edgington, T. S. Lethal escherichia-coli septic shock is prevented by blocking tissue factor with monoclonal-antibody Circulatory Shock 1991 33:127-134 PMID:2044206
- Ruf, W., Rehemtulla, A., Edgington, T. S. Phospholipid-independent and phospholipid-dependent interactions required for tissue factor receptor and cofactor function Journal of Biological Chemistry 1991 266:2158-2166 PMID:1989976
- Rehemtulla, A., Ruf, W., Edgington, T. S. The integrity of the cysteine-186-cysteine-209 bond of the 2nd disulfide loop of tissue factor is required for binding of factor-vii Journal of Biological Chemistry 1991 266:10294-10299 PMID:2037582
- Edgington, T. S., Mackman, N., Brand, K., Ruf, W. The structural biology of expression and function of tissue factor Thrombosis and Haemostasis 1991 66:67-79 PMID:1833852
- Ruf, W., Edgington, T. S. Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa Proceedings of the National Academy of Sciences of the United States of America 1991 88:8430-8434 DOI:10.1073/pnas.88.19.8430 PMID:1924302 PMCID:PMC52522
- Drake, T. A., Ruf, W., Morrissey, J. H., Edgington, T. S. Functional tissue factor is entirely cell-surface expressed on lipopolysaccharide-stimulated human-blood monocytes and a constitutively tissue factor producing neoplastic cell-line Journal of Cell Biology 1989 109:389-395 DOI:10.1083/jcb.109.1.389 PMID:2663880
- Ruf, W., Bender, A., Lane, D. A., Preissner, K. T., Selmayr, E., Mullerberghaus, G. Thrombin-induced fibrinopeptide-b release from normal and variant fibrinogens - influence of inhibitors of fibrin polymerization Biochimica et Biophysica Acta 1988 965:169-175 DOI:10.1016/0304-4165(88)90053-0 PMID:3365451
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- Gur-Cohen, S., Kollet, O., Graf, C., Esmon, C. T., Ruf, W., Lapidot, T. Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling Hematopoietic Stem Cells Ix. 65-81. 2016 DOI:10.1111/nyas.13013