Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options
Roush, William
Display my h-index
Publications in VIVO
 
    Export Publications Table
co-author
Co-author Network
map of science
Map of Science
Biosketch in .docx format  Create Biosketch

Roush, William

Faculty Member Emeritus
share the uri qr icon Close

Positions

  • 2018 - Professor Emeritus, Chemistry , Scripps Research
  • 2004 - Associate Dean, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2004 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2004 - 2018 Professor, Chemistry , Scripps Research
  • 1997 - 2005 Warner Lambert/Parke-Davis Professor of Chemistry, University of Michigan
  • 2002 - 2004 Chair, Department of Chemistry, University of Michigan
  • 1995 - 1997 Distinguished Professor of Chemistry, Indiana University
  • 1989 - 1995 Professor of Chemistry, Indiana University
  • 1987 - 1989 Associate Professor of Chemistry, Indiana University
  • 1983 - 1986 Associate Professor of Chemistry, Massachusetts Institute of Technology
  • 1978 - 1983 Assistant Professor of Chemistry, Massachusetts Institute of Technology
  • 1977 - 1978 Postdoctoral Fellow, Harvard University
Dr. William Roush focuses on the total synthesis of structurally complex and biologically interesting natural products, development of new synthetic methods and strategies, and on problems in medicinal and bioorganic chemistry.

Contact

  • roush@scripps.edu

Websites

  • William Roush, Ph.D.
  • Roush Laboratory
  • Wikipedia
  • Publications
  • Research
  • Teaching
  • Background
  • Contact
  • View All
scroll to property group menus

Publications

recent publications
  • All Publications
  • PubMed Display for Export
  • Publications without PubMed PMIDs

  • academic article

    • Nilchan, N., Alburger, J. M., Roush, W. R., Rader, C. An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation Biochemistry  2021 60:1080-1087  DOI:10.1021/acs.biochem.0c00955  PMID:33754696
    • Lo, C. H., Shay, G., McGuire, J. J., Li, T., Shain, K. H., Choi, J. Y., Fuerst, R., Roush, W. R., Knapinska, A. M., Fields, G. B., Lynch, C. C. Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival Cancer Research  2021 81:2415-2428  DOI:10.1158/0008-5472.Can-20-2705  PMID:33526510
    • Jilkova, A., Rubesova, P., Fanfrlik, J., Fajtova, P., Rezacova, P., Brynda, J., Lepsik, M., Mertlikova-Kaiserova, H., Emal, C. D., Renslo, A. R., Roush, W. R., Horn, M., et al. Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors Acs Infectious Diseases  2020 7:1077-1088  DOI:10.1021/acsinfecdis.0c00501  PMID:33175511  PMCID:PMC8154419
    • Vena, F., Bayle, S., Nieto, A., Quereda, V., Aceti, M., Frydman, S. M., Sansil, S. S., Grant, W., Monastyrskyi, A., McDonald, P., Roush, W. R., Teng, M. X., et al. Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase Molecular Cancer Therapeutics  2020 19:1623-1635  DOI:10.1158/1535-7163.Mct-19-0997  PMID:32430484  PMCID:PMC7415672
    • Maharaj, K., Powers, J. J., Achille, A., Mediavilla-Varela, M., Gamal, W., Burger, K. L., Fonseca, R., Jiang, K., Miskin, H. P., Maryanski, D., Monastyrskyi, A., Duckett, D. R., et al. The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells Blood Advances  2020 4:3072-3084  DOI:10.1182/bloodadvances.2020001800  PMID:32634240  PMCID:PMC7362385
    • Quereda, V., Bayle, S., Vena, F., Frydman, S. M., Monastyrskyi, A., Roush, W. R., Duckett, D. R. Therapeutic targeting of CDK12/CDK13 in triple-negative breast cancer Cancer Cell  2019 36:545-558  DOI:10.1016/j.ccell.2019.09.004  PMID:31668947
    • Renner, K., Bruss, C., Schnell, A., Koehl, G., Becker, H. M., Fante, M., Menevse, A. N., Kauer, N., Blazquez, R., Hacker, L., Decking, S. M., Bohn, T., et al. Restricting glycolysis preserves T cell effector functions and augments checkpoint therapy Cell Reports  2019 29:135-150  DOI:10.1016/j.celrep.2019.08.068  PMID:31577944
    • Hwang, D.*, Nilchan, N.*, Nanna, A. R., Li, X., Cameron, M. D., Roush, W. R., Park, H., Rader, C. Site-selective antibody functionalization via orthogonally reactive arginine and lysine residues Cell Chemical Biology  2019 26:1229-1239  DOI:10.1016/j.chembiol.2019.05.010  PMID:31231031  PMCID:PMC6754284 (* = equal contribution)
    • Doebelin, C., He, Y., Campbell, S., Nuhant, P., Kumar, N., Koenig, M., Garcia-Ordonez, R., Chang, M. R., Roush, W. R., Lin, L., Kahn, S., Cameron, M. D., et al. Discovery and optimization of a series of sulfonamide inverse agonists for the retinoic acid receptor-related orphan receptor-α Medicinal Chemistry  2019 15:676-684  DOI:10.2174/1573406415666190222124745  PMID:30799793
    • Fuerst, R., Yong Choi, J., Knapinska, A. M., Smith, L., Cameron, M. D., Ruiz, C., Fields, G. B., Roush, W. R. Development of matrix metalloproteinase-13 inhibitors - A structureactivity/structure-property relationship study Bioorganic & Medicinal Chemistry  2018 26:4984-4995  DOI:10.1016/j.bmc.2018.08.020  PMID:30249495
    • Persi, E., Duran-Frigola, M., Damaghi, M., Roush, W. R., Aloy, P., Cleveland, J. L., Gillies, R. J., Ruppin, E. Systems analysis of intracellular pH vulnerabilities for cancer therapy Nature Communications  2018 9  DOI:10.1038/s41467-018-05261-x  PMID:30065243  PMCID:PMC6068141
    • Zyserman, I., Mondal, D., Sarabia, F., McKerrow, J. H., Roush, W. R., Debnath, A. Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri Experimental Parasitology  2018 188:36-41  DOI:10.1016/j.exppara.2018.03.010  PMID:29551628  PMCID:PMC5918159
    • Monastyrskyi, A., Nilchan, N., Quereda, V., Noguchi, Y., Ruiz, C., Grant, W., Cameron, M., Duckett, D., Roush, W. Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer Bioorganic & Medicinal Chemistry  2018 26:590-602  DOI:10.1016/j.bmc.2017.12.020  PMID:29289448  PMCID:PMC5803353
    • Monastyrskyi, A., Bayle, S., Quereda, V., Grant, W., Cameron, M., Duckett, D., Roush, W. Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors Bioorganic & Medicinal Chemistry Letters  2018 28:400-404  DOI:10.1016/j.bmcl.2017.12.026  PMID:29277458
    • Wood, S. D., Grant, W., Adrados, I., Choi, J. Y., Alburger, J. M., Duckett, D. R., Roush, W. R. In silica HTS and structure based optimization of indazole-derived ULK1 inhibitors ACS Medicinal Chemistry Letters  2017 8:1258-1263  DOI:10.1021/acsmedchemlett.7b00344  PMID:29259744  PMCID:PMC5733266
    • Rondini, E. A., Mladenovic-Lucas, L., Roush, W. R., Halvorsen, G. T., Green, A. E., Granneman, J. G. Novel pharmacological probes reveal ABHD5 as a locus of lipolysis control in white and brown adipocytess Journal of Pharmacology and Experimental Therapeutics  2017 363:367-376  DOI:10.1124/jpet.117.243253  PMID:28928121  PMCID:PMC5698943
    • Nanna, A. R., Li, X., Walseng, E., Pedzisa, L., Goydel, R. S., Hymel, D., Burke, T. R., Roush, W. R., Rader, C. Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates Nature Communications  2017 8  DOI:10.1038/s41467-017-01257-1  PMID:29062027  PMCID:PMC5653646
    • Choi, J. Y., Fuerst, R., Knapinska, A. M., Taylor, A. B., Smith, L., Cao, X., Hart, P. J., Fields, G. B., Roush, W. R. Structure-based design and synthesis of potent and selective matrix metalloproteinase 13 inhibitors Journal of Medicinal Chemistry  2017 60:5816-5825  DOI:10.1021/acs.jmedchem.7b00514  PMID:28653849
    • Allais, C., Roush, W. R. Enantio- and diastereoselective synthesis of 1,5-syn-(Z)-amino alcohols via imine double allylboration: Synthesis of trans-1,2,3,6-tetrahydropyridines and total synthesis of andrachcine Organic Letters  2017 19:2646-2649  DOI:10.1021/acs.orglett.7b00995  PMID:28471668
    • Bhowmick, M., Tokmina-Roszyk, D., Onwuha-Ekpete, L., Harmon, K., Robichaud, T., Fuerst, R., Stawikowska, R., Steffensen, B., Roush, W., Wong, H. R., Fields, G. B. Second generation triple-helical peptide inhibitors of matrix metalloproteinases Journal of Medicinal Chemistry  2017 60:3814-3827  DOI:10.1021/acs.jmedchem.7b00018  PMID:28394608
    • Mason, J. W., Schmid, C. L., Bohn, L. M., Roush, W. R. Stolonidiol: Synthesis, target identification, and mechanism for choline acetyltransferase activation Journal of the American Chemical Society  2017 139:5865-5869  DOI:10.1021/jacs.7b01083  PMID:28414442
    • Getun, I. V., Wu, Z., Fallahi, M., Ouizem, S., Liu, Q., Li, W., Costi, R., Roush, W. R., Cleveland, J. L., Bois, P. R. J. Functional roles of acetylated histone marks at mouse meiotic recombination hot spots Molecular and Cellular Biology  2017 37:UNSP e00942-15  DOI:10.1128/mcb.00942-15  PMID:27821479  PMCID:PMC5247613
    • Calvet, C. M., Choi, J. Y., Thomas, D., Suzuki, B., Hirata, K., Lostracco-Johnson, S., de Mesquita, L. B., Nogueira, A., Meuser-Batista, M., Silva, T. A., Siqueira-Neto, J. L., Roush, W. R., et al. 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection PLoS Neglected Tropical Diseases  2017 11  DOI:10.1371/journal.pntd.0006132  PMID:29281643  PMCID:PMC5744913
    • Choi, J. Y., Roush, W. R. Structure Based Design of CYP51 Inhibitors Current Topics in Medicinal Chemistry  2017 17:30-39  DOI:10.2174/1568026616666160719164933  PMID:27449014
    • Patterson, J. T., Wilson, H. D., Asano, S., Nilchan, N., Fuller, R. P., Roush, W. R., Rader, C., Barbas III, C. F. Human serum albumin domain I fusion protein for antibody conjugation Bioconjugate Chemistry  2016 27:2271-2275  DOI:10.1021/acs.bioconjchem.6b00432  PMID:27666414
    • Walseng, E., Nelson, C. G., Qi, J., Nanna, A. R., Roush, W. R., Goswami, R. K., Sinha, S. C., Burke Jr., T. R., Rader, C. Chemically programmed bispecific antibodies in diabody format Journal of Biological Chemistry  2016 291:19661-19673  DOI:10.1074/jbc.M116.745588  PMID:27445334  PMCID:PMC5016699
    • Ewing, H., Fernandez-Vega, V., Spicer, T. P., Chase, P., Brown, S., Scampavia, L., Roush, W. R., Riley, S., Rosen, H., Hodder, P., Lambeau, G., Gelb, M. H. Fluorometric high-throughput screening assay for secreted phospholipases A(2) using phospholipid vesicles Journal of Biomolecular Screening  2016 21:713-721  DOI:10.1177/1087057116646742  PMID:27146384
    • Pedzisa, L., Li, X., Rader, C., Roush, W. R. Assessment of reagents for selenocysteine conjugation and the stability of selenocysteine adducts Organic & Biomolecular Chemistry  2016 14:5141-5147  DOI:10.1039/c6ob00775a  PMID:27184239  PMCID:PMC4887430
    • Nair, R. N., Mishra, J. K., Li, F., Tortosa, M., Yang, C., Doherty, J. R., Cameron, M., Cleveland, J. L., Roush, W. R., Bannister, T. D. Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors MedChemComm  2016 7:900-905  DOI:10.1039/c5md00579e  PMID:27347360
    • Jones, B. D., Tochowicz, A., Tang, Y., Cameron, M. D., McCall, L. I., Hirata, K., Siqueira-Neto, J. L., Reed, S. L., McKerrow, J. H., Roush, W. R. Synthesis and evaluation of oxyguanidine analogues of the cysteine protease inhibitor WRR-483 against cruzain ACS Medicinal Chemistry Letters  2016 7:77-82  DOI:10.1021/acsmedchemlett.5600336  PMID:26819670  PMCID:PMC4716606
    • Rosenberg, L. H., Lafitte, M., Quereda, V., Grant, W., Chen, W., Bibian, M., Noguchi, Y., Fallahi, M., Yang, C., Chang, J. C., Roush, W. R., Cleveland, J. L., et al. Therapeutic targeting of casein kinase 1δ in breast cancer Science Translational Medicine  2015 7:318ra202  DOI:10.1126/scitranslmed.aac8773  PMID:26676609  PMCID:PMC4809734
    • Sanders, M. A., Madoux, F., Mladenovic, L., Zhang, H., Ye, X., Angrish, M., Mottillo, E. P., Caruso, J. A., Halvorsen, G., Roush, W. R., Chase, P., Hodder, P., et al. Endogenous and synthetic ABHD5 ligands regulate ABHD5-perilipin interactions and lipolysis in fat and muscle Cell Metabolism  2015 22:851-860  DOI:10.1016/j.cmet.2015.08.023  PMID:26411340  PMCID:PMC4862007
    • Li, X., Patterson, J. T., Sarkar, M., Pedzisa, L., Kodadek, T., Roush, W. R., Rader, C. Site-specific dual antibody conjugation via engineered cysteine and selenocysteine residues Bioconjugate Chemistry  2015 26:2243-2248  DOI:10.1021/acs.bioconjchem.5600244  PMID:26161903
    • Schreiber, S. L., Kotz, J. D., Li, M., Aube, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., et al. Advancing biological understanding and therapeutics discovery with small-molecule probes Cell  2015 161:1252-1265  DOI:10.1016/j.cell.2015.05.023  PMID:26046436  PMCID:PMC4564295
    • El Hilali, X., Roush, W. R. Enantio- and diastereoselective synthesis of syn-β-hydroxy-α-alkenyl carboxamides via reductive aldol reactions of morpholine 4-methyl-2,3-pentadienoic carboxamide with diisopinocampheylborane Tetrahedron Letters  2015 56:3281-3284  DOI:10.1016/j.tetlet.2015.01.018
    • Penas, C., Govek, E. E., Fang, Y., Ramachandran, V., Daniel, M., Wang, W., Maloof, M. E., Rahaim, R. J., Bibian, M., Kawauchi, D., Finkelstein, D., Han, J. L., et al. Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis Cell Reports  2015 11:249-260  DOI:10.1016/j.celrep.2015.03.016  PMID:25843713  PMCID:PMC4401652
    • Ghalei, H., Schaub, F. X., Doherty, J. R., Noguchi, Y., Roush, W. R., Cleveland, J. L., Stroupe, M. E., Karbstein, K. Hrr25/CK1 delta-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth Journal of Cell Biology  2015 208:745-759  DOI:10.1083/jcb.201409056  PMID:25778921  PMCID:PMC4362465
    • Wang, Y., Stowe, R. L., Pinello, C. E., Tian, G., Madoux, F., Li, D., Zhao, L. Y., Li, J. L., Wang, Y., Wang, Y., Ma, H., Hodder, P., et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases Chemistry & Biology  2015 22:273-284  DOI:10.1016/j.chembiol.2014.12.015  PMID:25699604  PMCID:PMC4365786
    • Corzo, C. A., Mari, Y., Chang, M. R., Khan, T., Kuruvilla, D., Nuhant, P., Kumar, N., West, G. M., Duckett, D. R., Roush, W. R., Griffin, P. R. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1 Molecular Pharmacology  2015 87:296-304  DOI:10.1124/mol.114.095554  PMID:25473120  PMCID:PMC4293447
    • Penas, C., Mishra, J. K., Wood, S. D., Schurer, S. C., Roush, W. R., Ayad, N. G. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation Cell Cycle  2015 14:417-424  DOI:10.4161/15384101.2014.974439  PMID:25616418  PMCID:PMC4353296
    • Abbott, J. R., Allais, C., Roush, W. R. Preparattion of crystalline (diisopinocampheyl)borane Organic Syntheses  2015 92:26-37  DOI:10.15227/orgsyn.092.0026
    • Abbott, J. R., Allais, C., Roush, W. R. Enantioselective reductive syn-aldol reactions of 4-acryloylmorpholine: preparation of (2R, 3S)-3-hydroxy-2-methyl-1-morpholino-5-phenylpentan-1-one Organic Syntheses  2015 92:38-57  DOI:10.15227/orgsyn.092.0038
    • McCall, L. I., El Aroussi, A., Choi, J. Y., Vieira, D. F., De Muylder, G., Johnston, J. B., Chen, S., Kellar, D., Siqueira-Neto, J. L., Roush, W. R., Podust, L. M., McKerrow, J. H. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase PLoS Neglected Tropical Diseases  2015 9  DOI:10.1371/journal.pntd.0003588  PMID:25768284  PMCID:PMC4359151
    • Vieira, D. F., Choi, J. Y., Calvet, C. M., Siqueira-Neto, J. L., Johnston, J. B., Kellar, D., Gut, J., Cameron, M. D., McKerrow, J. H., Roush, W. R., Podust, L. M. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51 Journal of Medicinal Chemistry  2014 57:10162-10175  DOI:10.1021/jm501568b  PMID:25393646  PMCID:PMC4266343
    • Choi, J. Y., Podust, L. M., Roush, W. R. Drug strategies targeting CYP51 in neglected tropical diseases Chemical Reviews  2014 114:11242-11271  DOI:10.1021/cr5003134  PMID:25337991  PMCID:PMC4254036
    • Wang, H., Yang, C., Doherty, J. R., Roush, W. R., Cleveland, J. L., Bannister, T. D. Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors Journal of Medicinal Chemistry  2014 57:7317-7324  DOI:10.1021/jm500640x  PMID:25068893  PMCID:PMC4161152
    • Calvet, C. M., Vieira, D. F., Choi, J. Y., Kellar, D., Cameron, M. D., Siqueira-Neto, J. L., Gut, J., Johnston, J. B., Lin, L., Khan, S., McKerrow, J. H., Roush, W. R., et al. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency Journal of Medicinal Chemistry  2014 57:6989-7005  DOI:10.1021/jm500448u  PMID:25101801  PMCID:PMC4148169
    • Penas, C., Ramachandran, V., Simanski, S., Lee, C., Madoux, F., Rahaim, R. J., Chauhan, R., Barnaby, O., Schurer, S., Hodder, P., Steen, J., Roush, W. R., et al. Casein kinase 1 delta-dependent Wee1 protein degradation Journal of Biological Chemistry  2014 289:18893-18903  DOI:10.1074/jbc.M114.547661  PMID:24817118  PMCID:PMC4081930
    • Vieira, D. F., Choi, J. Y., Roush, W. R., Podust, L. M. Expanding the binding envelope of CYP51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives ChemBioChem  2014 15:1111-1120  DOI:10.1002/cbic.201402027  PMID:24771705  PMCID:PMC4091728
    • Choi, J. Y., Calvet, C. M., Vieira, D. F., Gunatilleke, S. S., Cameron, M. D., McKerrow, J. H., Podust, L. M., Roush, W. R. R-configuration of 4-aminopyridyl-based inhibitors of CYP51 confers superior efficacy against Trypanosoma cruzi ACS Medicinal Chemistry Letters  2014 5:434-439  DOI:10.1021/ml500010m  PMID:24900854  PMCID:PMC4027616
    • Doherty, J. R., Yang, C., Scott, K. E. N., Cameron, M. D., Fallahi, M., Li, W., Hall, M. A., Amelio, A. L., Mishra, J. K., Li, F., Tortosa, M., Genau, H. M., et al. Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis Cancer Research  2014 74:908-920  DOI:10.1158/0008-5472.can-13-2034  PMID:24285728  PMCID:PMC3946415
    • Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., Minong, D., Spicer, T. P. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro Journal of Medicinal Chemistry  2014 57:9598-9611  DOI:10.1021/jm501284e  PMID:25330343  PMCID:PMC4255739
    • Allais, C., Tsai, A. S., Nuhant, P., Roush, W. R. Generation of stereochemically defined tetrasubstituted enolborinates by 1,4-hydroboration of α,β-unsaturated morpholine carboxamides with (diisopinocampheyl)borane Angewandte Chemie-International Edition  2013 52:12888-12891  DOI:10.1002/anie.201307302  PMID:24281884  PMCID:PMC3910328
    • Kister, J., Ess, D. H., Roush, W. R. Enantio- and diastereoselective synthesis of syn-β-hydroxy-α-vinyl carboxylic esters via reductive aldol reactions of ethyl allenecarboxylate with 10-TMS-9-Borabicyclo[3.3.2]decane and DFT analysis of the hydroboration pathway Organic Letters  2013 15:5436-5439  DOI:10.1021/ol4025277  PMID:24138187  PMCID:PMC3849616
    • Choi, J. Y., Calvet, C. M., Gunatilleke, S. S., Ruiz, C., Cameron, M. D., McKerrow, J. H., Podust, L. M., Roush, W. R. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents Journal of Medicinal Chemistry  2013 56:7651-7668  DOI:10.1021/jm401067s  PMID:24079662  PMCID:PMC3864028
    • Nuhant, P., Allais, C., Roush, W. R. Diisopinocampheylborane-mediated reductive aldol reactions: highly enantio- and diastereoselective synthesis of syn aldols from N-acryloylmorpholine Angewandte Chemie-International Edition  2013 52:8703-8707  DOI:10.1002/anie.201302535  PMID:23818095  PMCID:PMC3813003
    • Allais, C., Nuhant, P., Roush, W. R. (Diisopinocampheyl)borane-mediated reductive aldol reactions of acrylate esters: enantioselective synthesis of anti-aldols Organic Letters  2013 15:3922-3925  DOI:10.1021/ol401679g  PMID:23885946  PMCID:PMC3773495
    • Bibian, M., Rahaim, R. J., Choi, J. Y., Noguchi, Y., Schurer, S., Chen, W. M., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., Feng, Y., Cameron, M. D., et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Bioorganic & Medicinal Chemistry Letters  2013 23:4374-4380  DOI:10.1016/j.bmcl.2013.05.075  PMID:23787102  PMCID:PMC3783656
    • Chen, M., Roush, W. R. Enantioselective synthesis of (Z)- and (E)-2-methyl-1,5-anti-pentenediols via an allene hydroboration-double-allylboration reaction sequence Journal of the American Chemical Society  2013 135:9512-9517  DOI:10.1021/ja4033633  PMID:23758559  PMCID:PMC3733567
    • Nuhant, P., Roush, W. R. Enantio- and diastereoselective synthesis of N-acetyl dihydrotetrafibricin methyl ester Journal of the American Chemical Society  2013 135:5340-5343  DOI:10.1021/ja401918r  PMID:23530855  PMCID:PMC3679187
    • Chen, M., Roush, W. R. Enantioselective synthesis of (E)-δ-silyl-anti-homoallylic alcohols via an enantiodivergent hydroboration-crotylboration reaction of a racemic allenylsilane Organic Letters  2013 15:1662-1665  DOI:10.1021/ol4004405  PMID:23534391  PMCID:PMC3663895
    • Chen, M., Roush, W. R. Crotylboron-based synthesis of the polypropionate units of chaxamycins a/d, salinisporamycin, and rifamycin s Journal of Organic Chemistry  2013 78:3-8  DOI:10.1021/jo3008226  PMID:22703288  PMCID:PMC3465507
    • Geist, J. G., Barth, R., Roush, W. R. Enantioselective synthesis of the C1-C11 fragment of tedanolide C Organic Letters  2013 15:58-61  DOI:10.1021/ol303089w  PMID:23249423  PMCID:PMC3539184
    • Abbott, J. R., Roush, W. R. Stereoselective synthesis of the disaccharide unit of incednine Organic Letters  2013 15:62-64  DOI:10.1021/ol303093z  PMID:23249392  PMCID:PMC3537911
    • Tsai, A. S., Chen, M., Roush, W. R. Chiral Brønsted acid catalyzed enantioselective synthesis of anti-homopropargyl alcohols via kinetic resolution-aldehyde allenylboration using racemic allenylboronates Organic Letters  2013 15:1568-1571  DOI:10.1021/ol4003459  PMID:23484801  PMCID:PMC3640598
    • Chen, M., Roush, W. R. Enantiodivergent hydroboration reactions of a racemic allenylsilane with diisopinocampheylborane and Curtin-Hammett controlled double asymmetric crotylboration reactions of (S)-E-α-phenyldimethylsilyl(ddiisopinocampheyl)-crotylborane Tetrahedron  2013 69:5468-5475  DOI:10.1016/j.tet.2013.04.098  PMID:24039304  PMCID:PMC3768161
    • Yang, H., Pinello, C. E., Luo, J., Li, D., Wang, Y., Zhao, L. Y., Jahn, S. C., Saldanha, S. A., Planck, J., Geary, K. R., Ma, H., Law, B. K., et al. Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents Molecular Cancer Therapeutics  2013 12:610-620  DOI:10.1158/1535-7163.mct-12-0930  PMID:23625935  PMCID:PMC3651759
    • Dossey, A. T., Whitaker, J. M., Dancel, M. C. A., Vander Meer, R. K., Bernier, U. R., Gottardo, M., Roush, W. R. Defensive spiroketals from Asceles glaber (Phasmatodea): absolute configuration and effects on ants and mosquitoes Journal of Chemical Ecology  2012 38:1105-1115  DOI:10.1007/s10886-012-0183-x  PMID:22976590  PMCID:PMC3473114
    • Han, J. L., Chen, M., Roush, W. R. Diastereo- and enantioselective synthesis of (E)-2-Methyl-1,2-syn- and (E)-2-Methyl-1,2-anti-3-pentenediols via allenylboronate kinetic resolution with ((d)Ipc)2BH and aldehyde allylboration Organic Letters  2012 14:3028-3031  DOI:10.1021/ol3010968  PMID:22646839  PMCID:PMC3426628
    • Chen, M., Roush, W. R. Enantioselective synthesis of (+)-crocacin C. An example of a highly challenging mismatched double asymmetric δ-stannylcrotylboration reaction Organic Letters  2012 14:1880-1883  DOI:10.1021/ol300476f  PMID:22409510  PMCID:PMC3321065
    • Chen, M., Roush, W. R. Enantioselective synthesis of (-)-basiliskamide A Organic Letters  2012 14:1556-1559  DOI:10.1021/ol300282e  PMID:22372693  PMCID:PMC3306514
    • Chen, M., Roush, W. R. Highly stereoselective synthesis of anti,anti-dipropionate stereotriads: a solution to the long-standing problem of challenging mismatched double asymmetric crotylboration reactions Journal of the American Chemical Society  2012 134:3925-3931  DOI:10.1021/ja300472a  PMID:22332989  PMCID:PMC3292054
    • Choi, J. Y., Plummer, M. S., Starr, J., Desbonnet, C. R., Soutter, H., Chang, J., Miller, J. R., Dillman, K., Miller, A. A., Roush, W. R. Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation Journal of Medicinal Chemistry  2012 55:852-870  DOI:10.1021/jm201349f  PMID:22243413  PMCID:PMC3306445
    • Chen, M., Roush, W. R. Total synthesis of (-)-tirandamycin C Organic Letters  2012 14:426-428  DOI:10.1021/ol203161u  PMID:22148850  PMCID:PMC3253220
    • Chen, M., Roush, W. R. Enantioselective synthesis of anti- and syn-homopropargyl alcohols via chiral Brønsted acid catalyzed asymmetric allenylboration reactions Journal of the American Chemical Society  2012 134:10947-10952  DOI:10.1021/ja3031467  PMID:22731887  PMCID:PMC3474359
    • Ying, M. B., Roush, W. R. Studies on the synthesis of reidispongiolide A: stereoselective synthesis of the C(22)-C(36) fragment Tetrahedron  2011 67:10274-10280  DOI:10.1016/j.tet2011.10.029  PMID:22711935  PMCID:PMC3375686
    • Roth, J., Minond, D., Darout, E., Liu, Q., Lauer, J., Hodder, P., Fields, G. B., Roush, W. R. Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds Bioorganic & Medicinal Chemistry Letters  2011 21:7180-7184  DOI:10.1016/j.bmcl.2011.09.077  PMID:22018790  PMCID:PMC3210410
    • Zhou, Y. C., Agudelo, J., Lu, K., Goetz, D. H., Hansell, E., Chen, Y. T., Roush, W. R., McKerrow, J., Craik, C. S., Amberg, S. M., Simmons, G. Inhibitors of SARS-CoV entry: identification using an internally-controlled dual envelope pseudovirion assay Antiviral Research  2011 92:187-194  DOI:10.1016/j.antiviral.2011.07.016  PMID:21820471  PMCID:PMC3205982
    • Nuhant, P., Kister, J., Lira, R., Sorg, A., Roush, W. R. Development of a double allylboration reagent targeting 1,5-syn-(E)-diols: application to the synthesis of the C(23)-C(40) fragment of tetrafibricin Tetrahedron  2011 67:6497-6512  DOI:10.1016/j.tet.2011.06.008  PMID:21857752  PMCID:PMC3156408
    • Busby, S. A., Kumar, N., Kuruvilla, D. S., Istrate, M. A., Conkright, J. J., Wang, Y. J., Kamenecka, T. M., Cameron, M. D., Roush, W. R., Burris, T. P., Griffin, P. R. Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors ACS Chemical Biology  2011 6:618-627  DOI:10.1021/cb100396s  PMID:21381756  PMCID:PMC3117942
    • Sun, H. K., Abbott, J. R., Roush, W. R. Stereoselective synthesis of a model C(18)-C(35) spiroketal fragment of integramycin Organic Letters  2011 13:2734-2737  DOI:10.1021/ol200834p  PMID:21510632  PMCID:PMC3094501
    • Lee, Y., Choi, J. Y., Fu, H., Harvey, C., Ravindran, S., Roush, W. R., Boothroyd, J. C., Khosla, C. Chemistry and biology of macrolide antiparasitic agents Journal of Medicinal Chemistry  2011 54:2792-2804  DOI:10.1021/jm101593u  PMID:21428405  PMCID:PMC3085955
    • Solt, L. A., Kumar, N., Nuhant, P., Wang, Y. J., Lauer, J. L., Liu, J., Istrate, M. A., Kamenecka, T. M., Roush, W. R., Vidovic, D., Schurer, S. C., Xu, J. H., et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand Nature  2011 472:491-494  DOI:10.1038/nature10075  PMID:21499262  PMCID:PMC3148894
    • Halvorsen, G. T., Roush, W. R. Stereoselective synthesis of the decahydrofluorene core of the hirsutellones Tetrahedron Letters  2011 52:2072-2075  DOI:10.1016/j.tetlet.2010.10.111  PMID:21503271  PMCID:PMC3077760
    • Chen, M., Roush, W. R. Enantioconvergent hydroboration of a racemic allene: enantioselective synthesis of (E)-δ-stannyl-anti-homoallylic alcohols via aldehyde crotylboration Journal of the American Chemical Society  2011 133:5744-5747  DOI:10.1021/ja2010187  PMID:21449594  PMCID:PMC3086366
    • Chen, M., Roush, W. R. Enantioselective syntheses of syn- and anti-beta-hydroxyallyisilanes via allene hydroboration-aldehyde allylboration reactions Organic Letters  2011 13:1992-1995  DOI:10.1021/ol200392u  PMID:21410173  PMCID:PMC3075570
    • Kister, J., Nuhant, P., Lira, R., Sorg, A., Roush, W. R. Enantio- and diastereoselective synthesis of (E)-1,5-syn-diols: application to the synthesis of the C(23)-C(40) fragment of tetrafibricin Organic Letters  2011 13:1868-1871  DOI:10.1021/ol2003836  PMID:21375316  PMCID:PMC3064748
    • Stewart, P. S., Chen, M., Roush, W. R., Ess, D. H. Thermodynamic control of 1,3-boratropic shifts of α- and γ-stannyl-substituted allylboranes: hyperconjugation outweighs steric effects Organic Letters  2011 13:1478-1481  DOI:10.1021/ol2001599  PMID:21323387  PMCID:PMC3462665
    • Kumar, N., Kojetin, D. J., Solt, L. A., Kumar, K. G., Nuhant, P., Duckett, D. R., Cameron, M. D., Butler, A. A., Roush, W. R., Griffin, P. R., Burris, T. P. Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist ACS Chemical Biology  2011 6:218-222  DOI:10.1021/cb1002762  PMID:21090593  PMCID:PMC3076127
    • Sun, H., Roush, W. R. Synthesis of (+)-B-allyldiisopinocampheylborane and its reaction with aldehydes Organic Syntheses  2011 88:87-101  DOI:10.1002/0471264229.os088.09  PMID:22962503
    • Sun, H., Roush, W. R. Synthesis of (S,S)-diisopropyl tartrate (E)-crotylboronate and its reaction with aldehydes: (2R,3R,4R)-1,2-dideoxy-2-ethenyl-4,5-O-(1-methylethylidene)xylitol Organic Syntheses  2011 88:181-196  DOI:10.1002/0471264229.os088.17  PMID:21666877
    • Wang, Y. J., Kumar, N., Nuhant, P., Cameron, M. D., Istrate, M. A., Roush, W. R., Griffin, P. R., Burris, T. P. Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ ACS Chemical Biology  2010 5:1029-1034  DOI:10.1021/cb100223d  PMID:20735016  PMCID:PMC3003750
    • Gianni, D., Taulet, N., Zhang, H., DerMardirossian, C., Kister, J., Martinez, L., Roush, W. R., Brown, S. J., Bokoch, G. M., Rosen, H. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells ACS Chemical Biology  2010 5:981-993  DOI:10.1021/cb100219n  PMID:20715845  PMCID:PMC2955773
    • Winbush, S. M., Roush, W. R. Enantioselective synthesis of (Z)-1,2-anti-2,5-anti-triol monosilyl ethers using a cross-metathesis allylboration sequence Organic Letters  2010 12:4344-4347  DOI:10.1021/ol101789g  PMID:20806914  PMCID:PMC2945398
    • Madoux, F., Simanski, S., Chase, P., Mishra, J. K., Roush, W. R., Ayad, N. G., Hodder, P. An ultra-high throughput cell-based screen for wee1 degradation inhibitors Journal of Biomolecular Screening  2010 15:907-917  DOI:10.1177/1087057110375848  PMID:20660794  PMCID:PMC3082437
    • Chen, Y. T., Brinen, L. S., Kerr, I. D., Hansell, E., Doyle, P. S., McKerrow, J. H., Roush, W. R. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi PLoS Neglected Tropical Diseases  2010 4:e825  DOI:10.1371/journal.pntd.0000825  PMID:20856868  PMCID:PMC2939063
    • Chen, M., Roush, W. R. Highly (E)-selective BF(3).Et(2)O-promoted allylboration of chiral nonracemic alpha-substituted allylboronates and analysis of the origin of stereocontrol Organic Letters  2010 12:2706-2709  DOI:10.1021/ol1007444  PMID:20476769  PMCID:PMC2891445
    • Chen, M., Ess, D. H., Roush, W. R. Enantioselective synthesis of (E)-delta-stannyl homoallylic alcohols via aldehyde allylboration using alpha-stannylallylboranes generated by allene hydroboration followed by a highly diastereoselective 1,3-boratropic shift Journal of the American Chemical Society  2010 132:7881-7883  DOI:10.1021/ja103041u  PMID:20496899  PMCID:PMC2890212
    • He, C., Nora, G. P., Schneider, E. L., Kerr, I. D., Hansell, E., Hirata, K., Gonzalez, D., Sajid, M., Boyd, S. E., Hruz, P., Cobo, E. R., Le, C., et al. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target Journal of Biological Chemistry  2010 285:18516-18527  DOI:10.1074/jbc.M109.086181  PMID:20378535  PMCID:PMC2881777
    • Barth, R., Roush, W. R. Enantioselective synthesis of alpha-methylene-beta-hydroxy carboxylic acid derivatives via a diastereoselective aldol/beta-elimination sequence: application to the C(15)-C(21) fragment of tedanolide C Organic Letters  2010 12:2342-2345  DOI:10.1021/ol1006955  PMID:20405855  PMCID:PMC2872132
    • Ess, D. H., Kister, J., Chen, M., Roush, W. R. Origin of thermodynamic versus kinetic control of allene hydroboration with 9-borabicyclo[3.3.1]nonane and 10(R)-trimethylsilyl-9-borabicyclo[3.3.2]decane Organic Letters  2009 11:5538-5541  DOI:10.1021/ol902364d  PMID:19899749  PMCID:PMC2803353
    • Ess, D. H., Kister, J., Chen, M., Roush, W. R. Quantum-mechanical study of 10-R-9-borabicyclo[3.3.2]decane alkene hydroboration Journal of Organic Chemistry  2009 74:8626-8637  DOI:10.1021/jo901737d  PMID:19824624  PMCID:PMC2803351
    • Chen, M., Handa, M., Roush, W. R. Enantioselective synthesis of 2-methyl-1,2-syn- and 2-methyl-1,2-anti-3-butenediols via allene hydroboration-aldehyde allylboration reaction sequences Journal of the American Chemical Society  2009 131:14602-14603  DOI:10.1021/ja904599h  PMID:19778012  PMCID:PMC2762002
    • Kister, J., DeBaillie, A. C., Lira, R., Roush, W. R. Stereoselective synthesis of gamma-substituted (Z)-allylic boranes via kinetically controlled hydroboration of allenes with 10-TMS-9-borabicyclo[3.3.2]decane Journal of the American Chemical Society  2009 131:14174-14175  DOI:10.1021/ja905494c  PMID:19775159  PMCID:PMC2767336
    • Dossey, A. T., Gottardo, M., Whitaker, J. M., Roush, W. R., Edison, A. S. Alkyldimethylpyrazines in the defensive spray of Phyllium westwoodii: a first for order Phasmatodea Journal of Chemical Ecology  2009 35:861-870  DOI:10.1007/s10886-009-9666-9  PMID:19685263  PMCID:PMC3787517
    • Li, F. Z., Roush, W. R. Stereloselective synthesis of syn,syn- and syn,anti-1,3,5-triols via intramolecular hydrosilylation of substituted pent-3-en-1,5-diols Organic Letters  2009 11:2932-2935  DOI:10.1021/ol9009877  PMID:19507846  PMCID:PMC2755244
    • Tortosa, M., Yakelis, N. A., Roush, W. R. Total synthesis of (+)-superstolide A Journal of Organic Chemistry  2008 73:9657-9667  DOI:10.1021/jo801794s  PMID:18956845  PMCID:PMC2736345
    • Dunetz, J. R., Julian, L. D., Newcom, J. S., Roush, W. R. Total syntheses of (+)-tedanolide and (+)-13-deoxytedanolide Journal of the American Chemical Society  2008 130:16407-16416  DOI:10.1021/ja8063205  PMID:18980317  PMCID:PMC2645944
    • Halvorsen, G. T., Roush, W. R. Siloxacyclopentenes as dienophile-linked directing groups in intramolecular Diels-Alder reactions Organic Letters  2008 10:5313-5316  DOI:10.1021/ol802266s  PMID:18954061  PMCID:PMC2650085
    • Chen, Y. T., Lira, R., Hansell, E., McKerrow, J. H., Roush, W. R. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors Bioorganic & Medicinal Chemistry Letters  2008 18:5860-5863  DOI:10.1016/j.bmcl.2008.06.012  PMID:18585034  PMCID:PMC2642929
    • Bates, R. H., Chen, M., Roush, W. R. Applications of chiral allylmetallating agents toward the synthesis of oxygen heterocycles Current Opinion in Drug Discovery & Development  2008 11:778-792  PMID:18946843
    • Pragani, R., Roush, W. R. Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone Organic Letters  2008 10:4613-4616  DOI:10.1021/ol8018727  PMID:18808128  PMCID:PMC2626543
    • Bates, R. H., Shotwell, J. B., Roush, W. R. Stereoselective syntheses of the C(1)-C(9) fragment of amphidinolide C Organic Letters  2008 10:4343-4346  DOI:10.1021/ol801852j  PMID:18783230  PMCID:PMC2650083
    • Huh, C. W., Roush, W. R. Highly stereoselective and modular syntheses of 10-hydroxytrilobacin and three diastereomers via stereodivergent [3 + 2]-annulation reactions Organic Letters  2008 10:3371-3374  DOI:10.1021/ol801242d  PMID:18588305
    • Roush, W. R. Total synthesis of biologically active natural products Journal of the American Chemical Society  2008 130:6654-6656  DOI:10.1021/ja8028813  PMID:18491856
    • Dunetz, J. R., Roush, W. R. Concerning the synthesis of the tedanolide C(13)-C(23) fragment via anti-aldol reaction Organic Letters  2008 10:2059-2062  DOI:10.1021/ol800546g  PMID:18422319
    • Roth, J., Madoux, F., Hodder, P., Roush, W. R. Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds Bioorganic & Medicinal Chemistry Letters  2008 18:2628-2632  DOI:10.1016/j.bmcl.2008.03.027  PMID:18374567  PMCID:PMC2592603
    • Winbush, S. M., Mergott, D. J., Roush, W. R. Total synthesis of (-)-spinosyn A: examination of structural features that govern the stereoselectivity of the key transannular Diels-Alder reaction Journal of Organic Chemistry  2008 73:1818-1829  DOI:10.1021/jo7024515  PMID:18215065
    • Tortosa, M., Yakelis, N. A., Roush, W. R. Total synthesis of (+)-superstolide A Journal of the American Chemical Society  2008 130:2722-2723  DOI:10.1021/ja710238h  PMID:18254629
    • Hicks, J. D., Roush, W. R. Synthesis of the C(26)-C(42) and C(43)-C(67) pyran-containing fragments of amphidinol 3 via a common pyran intermediate Organic Letters  2008 10:681-684  DOI:10.1021/ol703042q  PMID:18205377
    • Handa, M., Scheidt, K. A., Bossart, M., Zheng, N., Roush, W. R. Studies on the synthesis of apoptolidin A. 1. Synthesis of the C(1)-C(11) fragment Journal of Organic Chemistry  2008 73:1031-1035  DOI:10.1021/jo702250z  PMID:18163645
    • Handa, M., Smith, W. J., Roush, W. R. Studies on the synthesis of apoptolidin A. 2. Synthesis of the disaccharide unit Journal of Organic Chemistry  2008 73:1036-1039  DOI:10.1021/jo7022526  PMID:18163646
    • Hicks, J. D., Huh, C. W., Legg, A. D., Roush, W. R. Concerning the selective protection of (Z)-1,5-syn-ene-diols and (E)-1,5-anti-ene-diols as allylic triethylsilyl ethers Organic Letters  2007 9:5621-5624  DOI:10.1021/ol702588h  PMID:18027963  PMCID:PMC2504016
    • Lira, R., Roush, W. R. Enantio- and diastereoselective synthesis of syn-beta-hydroxyallylsilanes via a chiral (Z)-gamma-silylallylboronate Organic Letters  2007 9:4315-4318  DOI:10.1021/ol7018746  PMID:17867698
    • Goetz, D. H., Choe, Y., Hansell, E., Chen, Y. T., McDowell, M., Jonsson, C. B., Roush, W. R., McKerrow, J., Craik, C. S. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus Biochemistry  2007 46:8744-8752  DOI:10.1021/bi0621415  PMID:17605471
    • Melendez-Lopez, S. G., Herdman, S., Hirata, K., Choi, M. H., Choe, Y., Craik, C., Caffrey, C. R., Hansell, E., Chavez-Munguia, B., Chen, Y. T., Roush, W. R., McKerrow, J., et al. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model Eukaryotic Cell  2007 6:1130-1136  DOI:10.1128/ec.00094-07  PMID:17513563  PMCID:PMC1951106
    • Va, P., Roush, W. R. Total synthesis of amphidinolide E and amphidinolide E stereoisomers Tetrahedron  2007 63:5768-5796  DOI:10.1016/j.tet.2007.02.058  PMID:18575572  PMCID:PMC2031846
    • Halvorsen, G. T., Roush, W. R. Intramolecular Diels-Alder reactions of siloxacyclopentene constrained trienes Organic Letters  2007 9:2243-2246  DOI:10.1021/ol070858u  PMID:17480094  PMCID:PMC2504012
    • Lira, R., Roush, W. R. Stereoselective synthesis of the C(1)-C(19) fragment of tetrafibricin Organic Letters  2007 9:533-536  DOI:10.1021/ol0629869  PMID:17249805  PMCID:PMC2701644
    • Va, P., Roush, W. R. Synthesis of 2-epi-amphidinolide E: an unexpected and highly selective C(2)inversion during an esterification reaction Organic Letters  2007 9:307-310  DOI:10.1021/ol0628098  PMID:17217291  PMCID:PMC2593877
    • Va, P., Roush, W. R. Total synthesis of amphidinolide E Journal of the American Chemical Society  2006 128:15960-15961  DOI:10.1021/ja066663j  PMID:17165709  PMCID:PMC2538580
    • Trullinger, T. K., Qi, J., Roush, W. R. Studies on the synthesis of quartromicins A(3) and D(3): synthesis of the vertical and horizontal bis-spirotetronate fragments Journal of Organic Chemistry  2006 71:6915-6922  DOI:10.1021/jo061059c  PMID:16930045  PMCID:PMC2593838
    • Qi, J., Roush, W. R. Synthesis of precursors of the agalacto (exo) fragment of the quartromicins via an auxiliary-controlled exo-selective Diels-Alder reaction Organic Letters  2006 8:2795-2798  DOI:10.1021/ol0609208  PMID:16774259  PMCID:PMC2515626
    • Thalji, R. K., Roush, W. R. Remarkable phosphine-effect on the intramolecular aldol reactions of unsaturated 1,5-diketones: highly regioselective synthesis of cross-conjugated dienones Journal of the American Chemical Society  2005 127:16778-16779  DOI:10.1021/ja0540851  PMID:16316211  PMCID:PMC2515627
    • Lambert, W. T., Roush, W. R. Synthesis of the A-B subunit of angelmicin B Organic Letters  2005 7:5501-5504  DOI:10.1021/ol052321r  PMID:16288541
    • Hicks, J. D., Flamme, E. M., Roush, W. R. Synthesis of the C(43)-C(67) fragment of amphidinol 3 Organic Letters  2005 7:5509-5512  DOI:10.1021/ol052322j  PMID:16288543
    • Mertz, E., Tinsley, J. M., Roush, W. R. [3 + 2]-annulation reactions of chiral allylsilanes and chiral aldehydes. Studies on the synthesis of bis-tetrahydrofuran substructures of annonaceous acetogenins Journal of Organic Chemistry  2005 70:8035-8046  DOI:10.1021/jo0511290  PMID:16277325
    • Tinsley, J. M., Mertz, E., Chong, P. Y., Rarig, R. A. F., Roush, W. R. Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane Organic Letters  2005 7:4245-4248  DOI:10.1021/ol051719k  PMID:16146398  PMCID:PMC2507730
    • Owen, R. M., Roush, W. R. Stereoselective synthesis of the C(1)-C(11) fragment of peloruside A Organic Letters  2005 7:3941-3944  DOI:10.1021/ol0514303  PMID:16119937
    • Flamme, E. M., Roush, W. R. Synthesis of 2,6-trans-disubstituted 5,6-dihydropyrans from (Z)-1,5-syn-endiols Beilstein Journal of Organic Chemistry  2005 1:7  DOI:10.1186/1860-5397-1-7  PMID:16542020  PMCID:PMC1399455
    • Tinsley, J. M., Roush, W. R. Total synthesis of asimicin via highly stereoselective [3 + 2] annulation reactions of substituted allylsilanes Journal of the American Chemical Society  2005 127:10818-10819  DOI:10.1021/ja051986l  PMID:16076173
    • Heitzman, C. L., Lambert, W. T., Mertz, E., Shotwell, J. B., Tinsley, J. M., Va, P., Roush, W. R. Efficient protiodesilylation of unactivated C(sp3)-SiMe2Ph bonds using tetrabutylammonium fluoride Organic Letters  2005 7:2405-2408  DOI:10.1021/ol0506821  PMID:15932209  PMCID:PMC2515625
    • Julian, L. D., Newcom, J. S., Roush, W. R. Total synthesis of (+)-13-deoxytedanolide Journal of the American Chemical Society  2005 127:6186-6187  DOI:10.1021/ja050729d  PMID:15853320
    • Liu, C. M., Smith, W. J., Gustin, D. J., Roush, W. R. Experimental evidence for chair-like transition states in aldol reactions of methyl ketone lithium enolates: stereoselective synthesis and utilization of a deuterium-labeled enolate as a probe of reaction stereochemistry Journal of the American Chemical Society  2005 127:5770-5771  DOI:10.1021/ja050730c  PMID:15839658
    • Dineen, T. A., Roush, W. R. Stereoselective synthesis of the octahydronaphthalene unit of integramycin via an intramolecular Diels-Alder reaction Organic Letters  2005 7:1355-1358  DOI:10.1021/ol050191g  PMID:15787505
    • Flamme, E. M., Roush, W. R. Synthesis of the C(1)-C(25) fragment of amphidinol 3: application of the double-allylboration reaction for synthesis of 1,5-diols Organic Letters  2005 7:1411-1414  DOI:10.1021/ol050250q  PMID:15787519
    • Dias, L. C., Aguilar, A. M., Salles, A. G., Steil, L. J., Roush, W. R. Concerning the application of the 1H NMR ABX analysis for assignment of stereochemistry to aldols deriving from aldehydes lacking beta-branches Journal of Organic Chemistry  2005 70:10461-10465  DOI:10.1021/jo051773e  PMID:16323858
    • Narayan, S., Roush, W. R. Studies toward the total synthesis of angelmicin B (hibarimicin B): synthesis of a model CD-D' arylnaphthoquinone Organic Letters  2004 6:3789-3792  DOI:10.1021/ol048436x  PMID:15469350
    • Shotwell, J. B., Roush, W. R. Synthesis of the C11-C29 fragment of amphidinolide F Organic Letters  2004 6:3865-3868  DOI:10.1021/ol048381z  PMID:15469369
    • Mergott, D. J., Frank, S. A., Roush, W. R. Total synthesis of (-)-spinosyn A Proceedings of the National Academy of Sciences of the United States of America  2004 101:11955-11959  DOI:10.1073/pnas.0401247101  PMID:15173590  PMCID:PMC514415
    • Durham, T. B., Blanchard, N., Savall, B. M., Powell, N. A., Roush, W. R. Total synthesis of formamicin Journal of the American Chemical Society  2004 126:9307-9317  DOI:10.1021/ja048493i  PMID:15281821
    • Methot, J. L., Roush, W. R. Nucleophilic phosphine organocatalysis Advanced Synthesis & Catalysis  2004 346:1035-1050  DOI:10.1002/adsc.200404087
    • Roush, W. R., Neitz, R. J. Studies on the synthesis of landomycin A. Synthesis of the originally assigned structure of the aglycone, landomycinone, and revision of structure Journal of Organic Chemistry  2004 69:4906-4912  DOI:10.1021/jo049426c  PMID:15255715
    • Dineen, T. A., Roush, W. R. Total synthesis of cochleamycin A Organic Letters  2004 6:2043-2046  DOI:10.1021/ol049331x  PMID:15176814
    • Roush, W. R. Recent studies in carbonyl allylation reactions: application to the synthesis of oxygen heterocycles Actualite Chimique  2004 21-22
    • Coppola, B. P., Roush, W. R. Broadening the existing intergenerational structure of scholarly development in chemistry Peer Review  2004 6:19
    • Dineen, T. A., Roush, W. R. Probing the Lewis acid-catalyzed intramolecular Diels-Alder cyclizations of allylic alkoxy-substituted (Z)-1,3-dienes Organic Letters  2003 5:4725-4728  DOI:10.1021/ol035900+  PMID:14627425
    • Methot, J. L., Roush, W. R. Synthetic studies toward FR182877. Remarkable solvent effect in the vinylogous morita-baylis-hillman cyclization Organic Letters  2003 5:4223-4226  DOI:10.1021/ol0357550  PMID:14572290
    • Boitano, A., Emal, C. D., Leonetti, F., Blatt, N. B., Dineen, T. A., Ellman, J. A., Roush, W. R., Opipari, A. W., Glick, G. D. Structure activity studies of a novel cytotoxic benzodiazepine Bioorganic & Medicinal Chemistry Letters  2003 13:3327-3330  DOI:10.1016/s0960-894x(03)00683-8  PMID:12951119
    • Reddick, J. J., Cheng, J. M., Roush, W. R. Relative rates of Michael reactions of 2'-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors Organic Letters  2003 5:1967-1970  DOI:10.1021/ol034555l  PMID:12762698
    • Durham, T. B., Roush, W. R. Stereoselective synthesis of 2-deoxy-beta-galactosides via 2-deoxy-2-bromo- and 2-deoxy-2-iodo-galactopyranosyl donors Organic Letters  2003 5:1871-1874  DOI:10.1021/ol034393t  PMID:12762674
    • Durham, T. B., Roush, W. R. Stereoselective synthesis of functionalized precursors of the CDEF and CDE 2,6-dideoxy-tetra- and trisaccharide units of durhamycins A and B Organic Letters  2003 5:1875-1878  DOI:10.1021/ol034395d  PMID:12762675
    • Yakelis, N. A., Roush, W. R. Synthesis of the C(21)-C(26) fragment of superstolide A: concerning the stereochemistry of (E)-crotylboration reactions of alaninal derivatives Journal of Organic Chemistry  2003 68:3838-3843  DOI:10.1021/jo0341012  PMID:12737561
    • Heo, J. N., Holson, E. B., Roush, W. R. Common-intermediate strategy for synthesis of conduritols and inositols via beta-hydroxy cyclohexenylsilanes Organic Letters  2003 5:1697-1700  DOI:10.1021/ol034349d  PMID:12735755
    • Heo, J. N., Micalizio, G. C., Roush, W. R. Enantio- and diastereoselective synthesis of cyclic beta-hydroxy allylsilanes via sequential aldehyde gamma-silylallylboration and ring-closing metathesis reactions Organic Letters  2003 5:1693-1696  DOI:10.1021/ol034347t  PMID:12735754
    • Chemler, S. R., Roush, W. R. Stereochemistry of the allylation and crotylation reactions of alpha-methyl-beta-hydroxy aldehydes with allyl- and crotyltrifluorosilanes. Synthesis of anti, anti-dipropionate stereotriads and stereodivergent pathways for the reactions with 2,3-anti- and 2,3-syn-alpha-methyl-beta-hydroxy aldehydes Journal of Organic Chemistry  2003 68:1319-1333  DOI:10.1021/jo0267908  PMID:12585871
    • Savall, B. M., Blanchard, N., Roush, W. R. Total synthesis of the formamicin aglycon, formamicinone Organic Letters  2003 5:377-379  DOI:10.1021/ol027569k  PMID:12556196
    • Blanchard, N., Roush, W. R. 2-deoxy-2-iodo-beta-glucopyranosyl fluorides: mild and highly stereoselective glycosyl donors for the synthesis of 2-deoxy-beta-glycosides from beta-hydroxy ketones Organic Letters  2003 5:81-84  DOI:10.1021/ol027257h  PMID:12509896
    • Shenai, B. R., Lee, B. J., Alvarez-Hernandez, A., Chong, P. Y., Emal, C. D., Neitz, R. J., Roush, W. R., Rosenthal, P. J. Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones Antimicrobial Agents and Chemotherapy  2003 47:154-160  DOI:10.1128/aac.47.1.154-160.2003  PMID:12499184  PMCID:PMC149004
    • Roush, W. R., Newcom, J. S. Studies on the synthesis of tedanolide. 2. Stereoselective synthesis of a protected C(1)-C(12) fragment Organic Letters  2002 4:4739-4742  DOI:10.1021/ol0272343  PMID:12489975
    • Chong, P. Y., Roush, W. R. Concerning the origin of the high beta-selectivity of glycosidation reactions of 2-deoxy-2-iodo-glucopyranosyl trichloroacetimidates Organic Letters  2002 4:4523-4526  DOI:10.1021/ol027066e  PMID:12465928
    • Roush, W. R., Chen, H., Reilly, M. L. Studies on the synthesis of kijanolide: synthesis of an advanced seco-acid intermediate Heterocycles  2002 58:259-282  DOI:10.3987/COM-02-S(M)17
    • Flamme, E. M., Roush, W. R. Enantioselective synthesis of 1,5-anti- and 1,5-syn-diols using a highly diastereoselective one-pot double allylboration reaction sequence Journal of the American Chemical Society  2002 124:13644-13645  DOI:10.1021/ja028055j  PMID:12431072
    • Holson, E. B., Roush, W. R. Diastereoselective synthesis of the C(17)-C(28) fragment (the C-D spiroketal unit) of spongistatin 1 (altohyrtin A) via a kinetically controlled iodo-spiroketalization reaction Organic Letters  2002 4:3719-3722  DOI:10.1021/ol0266875  PMID:12375927
    • Holson, E. B., Roush, W. R. Synthesis of the C(2)-C(13) fragment (the A-B spiroketal unit) of spongistatin 1 (altohyrtin A): use of a common intermediate for the synthesis of both spongistatin spiroketals Organic Letters  2002 4:3723-3725  DOI:10.1021/ol026688x  PMID:12375928
    • Gung, B. W., Xue, X. W., Roush, W. R. The origin of diastereofacial control in allylboration reactions using tartrate ester derived allylboronates: attractive interactions between the Lewis acid coordinated aldehyde carbonyl group and an ester carbonyl oxygen Journal of the American Chemical Society  2002 124:10692-10697  DOI:10.1021/ja026373c  PMID:12207523
    • Mergott, D. J., Frank, S. A., Roush, W. R. Application of the intramolecular vinylogous Morita-Baylis-Hillman reaction toward the synthesis of the spinosyn A tricyclic nucleus Organic Letters  2002 4:3157-3160  DOI:10.1021/ol026540d  PMID:12201741
    • Roush, W. R., Barda, D. A., Limberakis, C., Kunz, R. K. Studies on the synthesis of the quartromicins: partial stereochemical assignment of quartromicins a(3) and d-3 and diastereoselective synthesis of the endo- and exo-spirotetronate subunits Tetrahedron  2002 58:6433-6454  DOI:10.1016/s0040-4020(02)00656-7
    • Hernandez, A. A., Roush, W. R. Recent advances in the synthesis, design and selection of cysteine protease inhibitors Current Opinion in Chemical Biology  2002 6:459-465  DOI:10.1016/s1367-5931(02)00345-9  PMID:12133721
    • Roush, W. R., Hertel, L., Schnaderbeck, M. J., Yakelis, N. A. Synthesis of the C(18)-(C26) segment of superstolide A Tetrahedron Letters  2002 43:4885-4887  DOI:10.1016/s0040-4039(02)00903-6
    • Scheidt, K. A., Bannister, T. D., Tasaka, A., Wendt, M. D., Savall, B. M., Fegley, G. J., Roush, W. R. Total synthesis of (-)-bafilomycin A(1) Journal of the American Chemical Society  2002 124:6981-6990  DOI:10.1021/ja017885e  PMID:12059221
    • Roush, W. R., Bannister, T. D., Wendt, M. D., VanNieuwenhze, M. S., Gustin, D. J., Dilley, G. J., Lane, G. C., Scheidt, K. A., Smith, W. J. An NMR method for assigning relative stereochemistry to beta-hydroxy ketones deriving from aldol reactions of methyl ketones Journal of Organic Chemistry  2002 67:4284-4289  DOI:10.1021/jo0164148  PMID:12054964
    • Frank, S. A., Roush, W. R. Studies on the synthesis of (-)-spinosyn A: application of the steric directing group strategy to transannular Diels-Alder reactions Journal of Organic Chemistry  2002 67:4316-4324  DOI:10.1021/jo025580s  PMID:12054969
    • Roush, W. R., Bannister, T. D., Wendt, M. D., Jablonowski, J. A., Scheidt, K. A. Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment Journal of Organic Chemistry  2002 67:4275-4283  DOI:10.1021/jo016413f  PMID:12054963
    • Frank, S. A., Mergott, D. J., Roush, W. R. The vinylogous intramolecular Morita-Baylis-Hillman reaction: synthesis of functionalized cyclopentenes and cyclohexenes with trialkylphosphines as nucleophilic catalysts Journal of the American Chemical Society  2002 124:2404-2405  DOI:10.1021/ja017123j  PMID:11890766
    • Roush, W. R., Limberakis, C., Kunz, R. K., Barda, D. A. Diastereoselective synthesis of the endo- and exo-spirotetronate subunits of the quartromicins. The first enantioselective Diels-Alder reaction of an acyclic (Z)-1,3-diene Organic Letters  2002 4:1543-1546  DOI:10.1021/ol025772+  PMID:11975624
    • Roush, W. R., Barda, D. A. Partial stereochemical assignment of quartromicins A3 and D3 Organic Letters  2002 4:1539-1542  DOI:10.1021/ol025771h  PMID:11975623
    • Roush, W. R., Powell, N. A., James, R. A. Synthesis of structurally simplified aureolic acid aglycone-C-D-E trisaccharide analogues Australian Journal of Chemistry  2002 55:113-121  DOI:10.1071/ch01198
    • Roush, W. R., James, R. A. Towards the synthesis of aureolic acid analogue conjugates: synthesis and glycosidation reactions of 3-O-acetyl-4-azido-2,4,6-trideoxy-L-glucopyranose derivatives Australian Journal of Chemistry  2002 55:141-146  DOI:10.1071/ch01199
    • Caffrey, C. R., Hansell, E., Lucas, K. D., Brinen, L. S., Hernandez, A. A., Cheng, J. N., Gwaltney, S. L., Roush, W. R., Stierhof, Y. D., Bogyo, M., Steverding, D., McKerrow, J. H. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense Molecular and Biochemical Parasitology  2001 118:61-73  DOI:10.1016/s0166-6851(01)00368-1  PMID:11704274
    • Roush, W. R., Madar, D. J., Coffey, D. S. Synthesis of highly functionalized naphthoate precursors to damavaricin D: observation of kinetically stable benzocyclohexadienones in the bromination reactions of highly functionalized beta-naphthol derivatives Canadian Journal of Chemistry-Revue Canadienne De Chimie  2001 79:1711-1726  DOI:10.1139/cjc-79-11-1711
    • Roush, W. R., Cheng, J. M., Knapp-Reed, B., Alvarez-Hernandez, A., McKerrow, J. H., Hansell, E., Engel, J. C. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain Bioorganic & Medicinal Chemistry Letters  2001 11:2759-2762  DOI:10.1016/s0960-894x(01)00566-2  PMID:11591518
    • Roush, W. R., Bennett, C. E., Roberts, S. E. Studies on the synthesis of landomycin A: synthesis and glycosidation reactions of L-rhodinosyl acetate derivatives Journal of Organic Chemistry  2001 66:6389-6393  DOI:10.1021/jo015756a  PMID:11559191
    • Savall, B. M., Powell, N. A., Roush, W. R. Highly diastereoselective synthesis of propargylic 1,2-anti-diol derivatives using alpha-alkoxypropargylstannanes Organic Letters  2001 3:3057-3060  DOI:10.1021/ol016536m  PMID:11554842
    • Micalizio, G. C., Roush, W. R. Studies on the synthesis of pectenotoxin II: synthesis of a C(11)-C(26) fragment precursor via [3 + 2]-annulation reactions of chiral allylsilanes Organic Letters  2001 3:1949-1952  DOI:10.1021/ol0160250  PMID:11405752
    • Menard, R., Therrien, C., Lachance, P., Sulea, T., Qi, H. T., Alvarez-Hernandez, A., Roush, W. R. Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design Biological Chemistry  2001 382:839-845  DOI:10.1515/bc.2001.102  PMID:11517939
    • Yakelis, N. A., Roush, W. R. Lewis acid catalyzed intramolecular Diels-Alder reactions of acyclic (Z)-substituted 1,3-dienes Organic Letters  2001 3:957-960  DOI:10.1021/ol015667k  PMID:11263925
    • Therrien, C., Lachance, P., Sulea, T., Purisima, E. O., Qi, H. T., Ziomek, E., Alvarez-Hernandez, A., Roush, W. R., Menard, R. Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities Biochemistry  2001 40:2702-2711  DOI:10.1021/bi002460a  PMID:11258881
    • Powell, N. A., Roush, W. R. Studies on the total synthesis of formamicin: synthesis of the C(1)-C(11) fragment Organic Letters  2001 3:453-456  DOI:10.1021/ol0069610  PMID:11428037
    • Roush, W. R., Dilley, G. J. Studies on the synthesis of 2,6-disubstituted dihydropyrans: intervention of oxonia-Cope rearrangements in the Lewis acid mediated cyclodehydrative reactions of aldehydes and beta-hydroxyallylsilanes Synlett  2001 2001:955-959  DOI:10.1055/s-2001-14632
    • Micalizio, G. C., Pinchuk, A. N., Roush, W. R. Synthesis of the C(29)-C(45) bis-pyran subunit (E-F) of spongistatin 1 (Altohyrtin A) Journal of Organic Chemistry  2000 65:8730-8736  DOI:10.1021/jo001236o  PMID:11112596
    • Roush, W. R., Hernandez, A. A., McKerrow, J. H., Selzer, P. M., Hansell, E., Engel, J. C. Design, synthesis and evaluation of D-homophenylalanyl epoxysuccinate inhibitors of the trypanosomal cysteine protease cruzain Tetrahedron  2000 56:9747-9762  DOI:10.1016/s0040-4020(00)00882-6
    • Roush, W. R., Pinchuk, A. N., Micalizio, G. C. (E)-gamma-(dimethylphenylsilyl)allyl diisopinocampheylborane: a highly enantioselective reagent for the synthesis of anti-beta-hydroxyallylsilanes Tetrahedron Letters  2000 41:9413-9417  DOI:10.1016/s0040-4039(00)01526-4
    • Frank, S. A., Chen, H., Kunz, R. K., Schnaderbeck, M. J., Roush, W. R. Use of thallium(I) ethoxide in Suzuki cross coupling reactions Organic Letters  2000 2:2691-2694  DOI:10.1021/ol0062446  PMID:10990429
    • Brinen, L. S., Hansell, E., Cheng, J. M., Roush, W. R., McKerrow, J. H., Fletterick, R. J. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease Structure with Folding & Design  2000 8:831-840  DOI:10.1016/s0969-2126(00)00173-8  PMID:10997902
    • Roush, W. R., Bennett, C. E. A highly stereoselective synthesis of the landomycin A hexasaccharide unit Journal of the American Chemical Society  2000 122:6124-6125  DOI:10.1021/ja000743k
    • Frank, S. A., Works, A. B., Roush, W. R. Studies on the synthesis of the decahydro-as-indacene ring system of (-)-spinosyn A via transannular Diels-Alder reactions of substituted (E,E,E)-cyclododeca-1,6,8-trienes Canadian Journal of Chemistry-Revue Canadienne De Chimie  2000 78:757-771  DOI:10.1139/cjc-78-6-757
    • Roush, W. R., Pfeifer, L. A. Total synthesis of mycalamide A and 7-epi-mycalamide A Organic Letters  2000 2:859-862  DOI:10.1021/ol005629l  PMID:10754688
    • Micalizio, G. C., Roush, W. R. A three-component coupling strategy for tetrahydrofuran synthesis: application of the diisopropyl tartrate modified (E)-gamma-(dimethylphenylsilyl)allylboronate as an alpha,gamma-allyl dianion equivalent Organic Letters  2000 2:461-464  DOI:10.1021/ol9913082  PMID:10814351
    • Roush, W. R., Gung, B. W., Bennett, C. E. 2-deoxy-2-iodo- and 2-deoxy-2-bromo-alpha-glucopyranosyl trichloroacetimidates: highly reactive and stereoselective donors for the synthesis of 2-deoxy-beta-glycosides Organic Letters  1999 1:891-893  DOI:10.1021/ol9908070  PMID:10823218
    • Roush, W. R., Narayan, S. 2-deoxy-2-iodo-alpha-mannopyranosyl and -talopyranosyl acetates: highly stereoselective glycosyl donors for the synthesis of 2-deoxy-alpha-glycosides Organic Letters  1999 1:899-902  DOI:10.1021/ol9908068  PMID:10823220
    • Roush, W. R., Narayan, S., Bennett, C. E., Briner, K. Iodoacetoxylation of glycals using cerium(IV) ammonium nitrate, sodium iodide, and acetic acid: stereoselective synthesis of 2-deoxy-2-iodo-alpha-mannopyranosyl acetates Organic Letters  1999 1:895-897  DOI:10.1021/ol990815g  PMID:10823219
    • Roush, W. R., Lane, G. C. Studies on the synthesis of tedanolide: synthesis of the C(5)-C(21) segment via a highly stereoselective fragment assembly aldol reaction of a chiral beta,gamma-unsaturated methyl ketone Organic Letters  1999 1:95-98  DOI:10.1021/ol990572s  PMID:10822542
    • Roush, W. R., Dilley, G. J. Studies of fragment assembly aldol reactions of chiral aldehydes and chiral methyl ketones: stereoselective synthesis of the C(13)-C(25) segment of scytophycin C Tetrahedron Letters  1999 40:4955-4959  DOI:10.1016/s0040-4039(99)00868-0
    • Chemler, S. R., Roush, W. R. Stereochemically divergent pathways for the allylation and crotylation reactions of anti- and syn-beta-hydroxy-alpha-methyl aldehydes with allyl- and crotyltrifluorosilanes Tetrahedron Letters  1999 40:4643-4647  DOI:10.1016/s0040-4039(99)00730-3
    • Micalizio, G. C., Roush, W. R. Towards the synthesis of spongistatin 1: diastereoselective synthesis of the C(36)-C(45) subunit Tetrahedron Letters  1999 40:3351-3354  DOI:10.1016/s0040-4039(99)00464-5
    • Roush, W. R., Bennett, C. E. A highly stereoselective synthesis of 2-deoxy-beta-glycosides using 2-deoxy-2-iodo-glucopyranosyl acetate donors Journal of the American Chemical Society  1999 121:3541-3542  DOI:10.1021/ja984365j
    • Chemler, S. R., Coffey, D. S., Roush, W. R. An improved synthesis of the (E,Z)-dienoate precursor of (+)-damavaricin D via a vinylogous Horner-Wadsworth-Emmons reaction Tetrahedron Letters  1999 40:1269-1272  DOI:10.1016/s0040-4039(98)02638-0
    • Roush, W. R., Hernandez, A. A., Zepeda, G. A new synthesis of peptidyl epoxysuccinates for probing cysteine protease-inhibitor p-3/s-3 binding interactions Synthesis-Stuttgart  1999 1999:1500-1504  DOI:10.1055/s-1999-3648
    • Scheidt, K. A., Tasaka, A., Bannister, T. D., Wendt, M. D., Roush, W. R. Total synthesis of (-)-bafilomycin A(1): application of diastereoselective crotylboration and methyl ketone aldol reactions Angewandte Chemie-International Edition  1999 38:1652-1655  DOI:10.1002/(sici)1521-3773(19990601)38:11<1652::aid-anie1652>3.0.co;2-k
    • Roush, W. R., Hartz, R. A., Gustin, D. J. Total synthesis of olivomycin A Journal of the American Chemical Society  1999 121:1990-1991  DOI:10.1021/ja984229e
    • Scheidt, K. A., Roush, W. R., McKerrow, J. H., Selzer, P. M., Hansell, E., Rosenthal, P. J. Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors Bioorganic & Medicinal Chemistry  1998 6:2477-2494  DOI:10.1016/s0968-0896(98)80022-9  PMID:9925304
    • Roush, W. R., Gwaltney, S. L., Cheng, J. M., Scheidt, K. A., McKerrow, J. H., Hansell, E. Vinyl sulfonate esters and vinyl sulfonamides: potent, irreversible inhibitors of cysteine proteases Journal of the American Chemical Society  1998 120:10994-10995  DOI:10.1021/ja981792o
    • Roush, W. R., Gonzalez, F. V., McKerrow, J. H., Hansell, E. Design and synthesis of dipeptidyl alpha',beta '-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain Bioorganic & Medicinal Chemistry Letters  1998 8:2809-2812  DOI:10.1016/s0960-894x(98)00494-6  PMID:9873627
    • Scheidt, K. A., Chen, H., Follows, B. C., Chemler, S. R., Coffey, D. S., Roush, W. R. Tris(dimethylamino)sulfonium difluorotrimethylsilicate, a mild reagent for the removal of silicon protecting groups Journal of Organic Chemistry  1998 63:6436-6437  DOI:10.1021/jo981215i
    • Roush, W. R., Sciotti, R. J. Studies on the synthesis of chlorothricolide: diastereo- and enantioselective syntheses of model top-half spirotetronate units Journal of Organic Chemistry  1998 63:5473-5482  DOI:10.1021/jo980379w
    • Roush, W. R., Sciotti, R. J. Enantioselective total synthesis of (-)-chlorothricolide via the tandem inter- and intramolecular Diels-Alder reaction of a hexaenoate intermediate Journal of the American Chemical Society  1998 120:7411-7419  DOI:10.1021/ja980611f
    • Chemler, S. R., Roush, W. R. Concerning the synthesis of the elusive anti,anti-dipropionate stereotriad via the crotylation of beta-hydroxy alpha-methyl aldehydes with (Z)-crotyltrifluorosilane. Application to the synthesis of the C(7)-C(16) segment of zincophorin Journal of Organic Chemistry  1998 63:3800-3801  DOI:10.1021/jo980387c
    • Roush, W. R., Pfeifer, L. A. Stereoselective N-acylation reactions of alpha-alkoxy carbamates Journal of Organic Chemistry  1998 63:2062-2063  DOI:10.1021/jo980024c
    • Roush, W. R., Pfeifer, L. A., Marron, T. G. Studies on the synthesis of the mycalamides: Stereocontrolled synthesis of a model N-glycosylpederamide via a stereoselective aldol reaction Journal of Organic Chemistry  1998 63:2064-2065  DOI:10.1021/jo980023k
    • Roush, W. R., Barda, D. A. An intramolecular Diels-Alder approach to the spirotetronic acid subunits of the quartromicins Tetrahedron Letters  1997 38:8781-8784  DOI:10.1016/s0040-4039(97)10415-4
    • Roush, W. R., Barda, D. A. Second generation synthesis of the quartromicin spirotetronic acid subunits via a Claisen rearrangement intramolecular aldol sequence Tetrahedron Letters  1997 38:8785-8788  DOI:10.1016/s0040-4039(97)10416-6
    • Roush, W. R., Reilly, M. L., Koyama, K., Brown, B. B. A formal total synthesis of (+)-tetronolide, the aglycon of the tetrocarcins: enantio- and diastereoselective syntheses of the octahydronaphthalene (bottom-half) and spirotetronate (top-half) fragments Journal of Organic Chemistry  1997 62:8708-8721  DOI:10.1021/jo970960c
    • Roush, W. R., Coffey, D. S., Madar, D. J. Total synthesis of (+)-damavaricin D Journal of the American Chemical Society  1997 119:11331-11332  DOI:10.1021/ja971828x
    • Roush, W. R., Barda, D. A. Highly selective Lewis acid catalyzed Diels-Alder reactions of acyclic (Z)-1,3-dienes Journal of the American Chemical Society  1997 119:7402-7403  DOI:10.1021/ja971070h
    • Roush, W. R., Sebesta, D. P., Bennett, C. E. Stereoselective synthesis of 2-deoxy-beta-glycosides from glycal precursors. 1. Stereochemistry of the reactions of D-glucal derivatives with phenylsulfenyl chloride and phenylselenenyl chloride Tetrahedron  1997 53:8825-8836  DOI:10.1016/s0040-4020(97)90394-x
    • Roush, W. R., Sebesta, D. P., James, R. A. Stereoselective synthesis of 2-deoxy-beta-glycosides from glycal precursors. 2. Stereochemistry of glycosidation reactions of 2-thiophenyl- and 2-selenophenyl-alpha-D-gluco-pyranosyl donors Tetrahedron  1997 53:8837-8852  DOI:10.1016/s0040-4020(97)00572-3
    • Hunt, J. A., Roush, W. R. 4,5-diisopropyl-B-[(E)-[(3'-menthofuryl)dimethylsilyl]allyl]-1,3,2-dioxaborolane, an improved chiral reagent for the anti alpha-hydroxyallylation of aldehydes: application to the enantioselective synthesis of (-)-swainsonine Journal of Organic Chemistry  1997 62:1112-1124  DOI:10.1021/jo961840s
    • Roush, W. R., Marron, T. G., Pfeifer, L. A. Highly diastereoselective synthesis of pederic acid derivatives Journal of Organic Chemistry  1997 62:474-478  DOI:10.1021/jo961841k  PMID:11671436
    • Roush, W. R., Works, A. B. Diastereofacially selective enolate Claisen rearrangements of 4-7-eta 4-(1-acyloxy-2,4,6-octatrienyl) tricarbonyliron complexes Tetrahedron Letters  1997 38:351-354  DOI:10.1016/s0040-4039(96)02349-0
    • Roush, W. R., Champoux, J. A., Peterson, B. C. Diastereoselective synthesis of the cis-octahydronaphthalene nucleus of superstolides A and B Tetrahedron Letters  1996 37:8989-8992  DOI:10.1016/s0040-4039(96)02110-7
    • Roush, W. R., Works, A. B. Diastereoselective synthesis of the trans-anti-cis-decahydro-as-indacene ring system via the transannular Diels-Alder reaction of a functionalized (E,E,E)-cyclododeca-1,6,8-triene Tetrahedron Letters  1996 37:8065-8068  DOI:10.1016/0040-4039(96)01840-0
    • Hunt, J. A., Roush, W. R. Solid-phase synthesis of 6-deoxyoligosaccharides Journal of the American Chemical Society  1996 118:9998-9999  DOI:10.1021/ja962128f
    • Roush, W. R., Briner, K., Kesler, B. S., Murphy, M., Gustin, D. J. Studies on the synthesis of aureolic acid antibiotics: acyloin glycosidation studies Journal of Organic Chemistry  1996 61:6098-6099  DOI:10.1021/jo960932e  PMID:11667440
    • Roush, W. R., Coffey, D. S., Madar, D., Palkowitz, A. D. Studies on the synthesis of the streptovaricins: total synthesis of 24,27-dimethyl dihydrodamavaricin D Journal of the Brazilian Chemical Society  1996 7:327-334
    • Roush, W. R., Koyama, K., Curtin, M. L., Moriarty, K. J. Studies on the synthesis of nargenicin A(1): highly stereoselective synthesis of the complete carbon framework via the transannular Diels-Alder reaction of an 18-membered macrolide Journal of the American Chemical Society  1996 118:7502-7512  DOI:10.1021/ja9607796
    • Roush, W. R., Coffey, D. S. Synthesis of the naphthoquinone nucleus of awamycin Journal of Organic Chemistry  1995 60:4412-4418  DOI:10.1021/jo00119a018
    • Gustin, D. J., Vannieuwenhze, M. S., Roush, W. R. Diastereoselective aldol reactions of chiral aldehydes and chiral methyl ketones: dependence of stereoselectivity on the metal enolate, the aldehyde 2,3-stereochemistry, and the aldehyde β-alkoxy protecting group Tetrahedron Letters  1995 36:3443-3446  DOI:10.1016/0040-4039(95)00626-n
    • Gustin, D. J., Vannieuwenhze, M. S., Roush, W. R. Synthesis of the C(3)-C(15) segment of rutamycin B via a C(8)-C(9) fragment assembly aldol reaction: metal dependence of the aldehyde and enolate diastereofacial selectivities Tetrahedron Letters  1995 36:3447-3450  DOI:10.1016/0040-4039(95)00628-p
    • Marron, T. G., Roush, W. R. Diastereoselective synthesis of N-benzoyl mycalamine, the fully elaborated trioxadecalin nucleus of mycalamide. A. Control of the key N-acyl aminal stereocenter via carbamate acylation Tetrahedron Letters  1995 36:1581-1584  DOI:10.1016/0040-4039(95)00093-r
    • Roush, W. R., Lin, X. F. Studies on the synthesis of aureolic acid antibiotics: highly stereoselective synthesis of aryl 2-deoxy-beta-glycosides via the Mitsunobu reaction and synthesis of the olivomycin A-B disaccharide Journal of the American Chemical Society  1995 117:2236-2250  DOI:10.1021/ja00113a013
    • Hunt, J. A., Roush, W. R. Diisopropyl tartrate-modified (E)-γ-[(menthofuryl)dimethylsilyl]-allyl boronate, an improved chiral reagent for the anti α-hydroxyallylation of aldehydes. Application to the enantioselective synthesis of (−)-swainsonine Tetrahedron Letters  1995 36:501-504  DOI:10.1016/0040-4039(94)02295-m
    • Roush, W. R., Hunt, J. A. Asymmetric allylboration of 2-N,3-O-isopropylidene-N-boc-L-serinal: diastereoselective synthesis of the calicheamicin gamma1I amino sugar Journal of Organic Chemistry  1995 60:798-806  DOI:10.1021/jo00109a008
    • Roush, W. R., Grover, P. T. N,N'-bis(2,2,2-trifluoroethyl)-N,N'-ethylenetartramide: an improved chiral auxiliary for the asymmetric allylboration reaction Journal of Organic Chemistry  1995 60:3806-3813  DOI:10.1021/jo00117a036
    • Wada, C. K., Roush, W. R. Highly stereoselective 1,4-addition reactions of alkylidene malonate substituted η4-(1,3-butadienyl)iron(tricarbonyl) complexes Tetrahedron Letters  1994 35:7351-7354  DOI:10.1016/0040-4039(94)85311-8
    • Roush, W. R., Wada, C. K. Highly stereoselective substitution reactions of functionalized η4-[3(E),5(E)-heptadien-2-ol]iron tricarbonyl complexes Tetrahedron Letters  1994 35:7347-7350  DOI:10.1016/0040-4039(94)85310-x
    • Roush, W. R., Vannieuwenhze, M. S. [(Z)-gamma-[(Diisopropylidene-alpha-D-mannopyranosyl)oxy]allyl]tributylstannane: a new chiral reagent for the asymmetric alpha-hydroxyallylation of aldehydes Journal of the American Chemical Society  1994 116:8536-8543  DOI:10.1021/ja00098a014
    • Li, Z., Chen, X., Davidson, E., Zwang, O., Mendis, C., Ring, C. S., Roush, W. R., Fegley, G., Li, R., Rosenthal, P. J., Lee, G. K., Kenyon, G. L., et al. Anti-malarial drug development using models of enzyme structure Chemistry & Biology  1994 1:31-37  DOI:10.1016/1074-5521(94)90038-8  PMID:9383368
    • Roush, W. R., Sciotti, R. J. Enantioselective total synthesis of (-)-chlorothricolide Journal of the American Chemical Society  1994 116:6457-6458  DOI:10.1021/ja00093a065
    • Roush, W. R., Gustin, D. A stereochemically general synthesis of methyl 2,4,6-trideoxy-4-methylthio-α-D-ribo-pyranoside, the thio sugar of esperamicin A(1) Tetrahedron Letters  1994 35:4931-4934  DOI:10.1016/s0040-4039(00)73285-0
    • Roush, W. R., Follows, B. C. Asymmetric synthesis of the hydroxylamino sugar of calicheamicin Tetrahedron Letters  1994 35:4935-4938  DOI:10.1016/s0040-4039(00)73286-2
    • Roush, W. R., Wada, C. K. Application of eta4-diene iron tricarbonyl complexes in acyclic stereocontrol: asymmetric synthesis of the as-indacene unit of ikarugamycin (a formal total synthesis) Journal of the American Chemical Society  1994 116:2151-2152  DOI:10.1021/ja00084a068
    • Roush, W. R., Grover, P. T., Marron, T. G. Allylboronates in organic synthesis: design of an improved chiral auxiliary and synthesis of the trioxadecalin nucleus of mycalamides A and B Special publication (Royal Society of Chemistry (Great Britain))  1994 143:113-118
    • Roush, W. R., Bannister, T. D., Wendt, M. D. Concerning the diastereofacial selectivity of aldol reactions of chiral methyl ketone enolates: evidence for remote chelation in the bafilomycin aldol reaction Tetrahedron Letters  1993 34:8387-8390  DOI:10.1016/s0040-4039(00)61340-0
    • Roush, W. R., Lin, X. F. Synthesis of naphthyl A–B disaccharides corresponding to olivomycin A and mithramycin Tetrahedron Letters  1993 34:6829-6832  DOI:10.1016/s0040-4039(00)91806-9
    • Roush, W. R., Warmus, J. S., Works, A. B. Synthesis and transannular diels-alder reactions of (E,E,E)-cyclotetradeca-2,8,10-trienones Tetrahedron Letters  1993 34:4427-4430  DOI:10.1016/0040-4039(93)88050-s
    • Roush, W. R., Brown, B. B. A highly diastereoselective and enantioselective synthesis of the top half of kijanolide Journal of Organic Chemistry  1993 58:2151-2161  DOI:10.1021/jo00060a035
    • Roush, W. R., Brown, B. B. Studies on the synthesis of kijanolide: synthesis of the 2-acyl spiro tetronate and investigations concerning the coupling of the top and bottom half fragments Journal of Organic Chemistry  1993 58:2162-2172  DOI:10.1021/jo00060a036
    • Roush, W. R., Briner, K., Sebesta, D. P. Highly stereoselective synthesis of alpha-L-olivomycosides via trimethylsilyl triflate mediated glycosidations of 1-O-acetyl-4-O-isobutyryl-2,6-dideoxy-2-iodo-3-C-methyl-alpha-L-mannopyranose Synlett  1993 1993:264-266  DOI:10.1055/s-1993-22425
    • Roush, W. R., Brown, B. B. Application of the steric directing group strategy to the stereoselective synthesis of the octahydronaphthalene substructure of kijanolide and tetronolide Journal of the American Chemical Society  1993 115:2268-2278  DOI:10.1021/ja00059a024
    • Roush, W. R., Madar, D. J. Towards the synthesis of streptovaricin D: synthesis of fully elaborated aromatic precursors and coupling with ansa chain fragments Tetrahedron Letters  1993 34:1553-1556  DOI:10.1016/0040-4039(93)85004-g
    • Roush, W. R., Marron, T. G. Toward the synthesis of mycalamides A, B and onnamide A: a highly stereoselective synthesis of the trioxadecalin ring system Tetrahedron Letters  1993 34:5421-5424  DOI:10.1016/s0040-4039(00)73924-4
    • Roush, W. R., Murphy, M. An improved synthesis of naphthoate precursors to olivin Journal of Organic Chemistry  1992 57:6622-6629  DOI:10.1021/jo00050a047
    • Roush, W. R., Koyama, K. Enantioselective synthesis of the top half of tetronolide Tetrahedron Letters  1992 33:6227-6230  DOI:10.1016/s0040-4039(00)60939-5
    • Sebesta, D. P., Roush, W. R. Synthesis of C-D-E trisaccharide precursors of olivomycin A Journal of Organic Chemistry  1992 57:4799-4802  DOI:10.1021/jo00044a010
    • Roush, W. R., Sciotti, R. J. Enantioselective synthesis of the top half of chlorothricolide Tetrahedron Letters  1992 33:4691-4694  DOI:10.1016/s0040-4039(00)61260-1
    • Roush, W. R., Bannister, T. D. Stereoselective synthesis of the C(13)-C(25) segment of bafilomycin A(1) Tetrahedron Letters  1992 33:3587-3590  DOI:10.1016/s0040-4039(00)92509-7
    • Roush, W. R., Brown, B. B. Enantioselective synthesis of 2-alkyl-5-methylene-1,3-dioxolan-4-ones and exo-selective Diels-Alder reactions with cyclopentadiene Journal of Organic Chemistry  1992 57:3380-3387  DOI:10.1021/jo00038a028
    • Roush, W. R., Ratz, A. M., Jablonowski, J. A. Solid-state and solution conformational-analysis of tartrate-derived 1,3-dioxolanes and 1,3,2-dioxaborolanes Journal of Organic Chemistry  1992 57:2047-2052  DOI:10.1021/jo00033a027
    • Roush, W. R., Grover, P. T. Diisopropyl tartrate modified (E)-γ-[(cyclohexyloxy)dimethylsilyl]- and (E)-γ-(dimethylphenylsilyl)allylboronates: chiral reagents for the enantio- and diastereoselective synthesis of anti 1,2-diols and 2-butene-1,4-diols via the formal α- and γ-hydroxyallylation of aldehydes Tetrahedron  1992 48:1981-1998  DOI:10.1016/s0040-4020(01)88869-4
    • Roush, W. R., Park, J. C. Asymmetric allylborations of 3-decynal dicobalt hexacarbonyl: cobalt induced reversal of enantioselectivity and applications to highly diastereoselective intramolecular Pauson-Khand reactions Tetrahedron Letters  1991 32:6285-6288  DOI:10.1016/0040-4039(91)80148-y
    • Roush, W. R., Lin, X. F. A highly stereoselective synthesis of aryl 2-deoxy-beta-glycosides via the Mitsunobu reaction Journal of Organic Chemistry  1991 56:5740-5742  DOI:10.1021/jo00020a003
    • Roush, W. R. Concerning the diastereofacial selectivity of the aldol reactions of alpha-methyl chiral aldehydes and lithium and boron propionate enolates Journal of Organic Chemistry  1991 56:4151-4157  DOI:10.1021/jo00013a015
    • Roush, W. R., Lin, X. F., Straub, J. A. A highly stereoselective synthesis of the AB disaccharide unit of olivomycin A Journal of Organic Chemistry  1991 56:1649-1655  DOI:10.1021/jo00004a054
    • Roush, W. R., Straub, J. A., Vannieuwenhze, M. S. A stereochemically general synthesis of 2-deoxyhexoses via the asymmetric allylboration of 2,3-epoxyaldehydes Journal of Organic Chemistry  1991 56:1636-1648  DOI:10.1021/jo00004a053
    • Roush, W. R., Kageyama, M., Riva, R., Brown, B. B., Warmus, J. S., Moriarty, K. J. Enantioselective synthesis of the bottom half of chlorothricolide. 3. Studies of the steric directing group strategy for stereocontrol in intramolecular Diels-Alder reactions Journal of Organic Chemistry  1991 56:1192-1210  DOI:10.1021/jo00003a049
    • Roush, W. R., Palkowitz, A. D., Ando, K. Acyclic diastereoselective synthesis using tartrate ester modified crotylboronates: double asymmetric reactions with alpha-methyl chiral aldehydes and synthesis of the C19-C29 segment of rifamycin S Journal of the American Chemical Society  1990 112:6348-6359  DOI:10.1021/ja00173a024
    • Roush, W. R., Ando, K., Powers, D. B., Palkowitz, A. D., Halterman, R. L. Asymmetric-synthesis using diisopropyl tartrate modified (E)-crotylboronates and (Z)-crotylboronates: preparation of the chiral crotylboronates and reactions with achiral aldehydes Journal of the American Chemical Society  1990 112:6339-6348  DOI:10.1021/ja00173a023
    • Roush, W. R., Hoong, L. K., Palmer, M. A. J., Straub, J. A., Palkowitz, A. D. Asymmetric synthesis using tartrate ester modified allylboronates. 2. Single and double asymmetric reactions with alkoxy-substituted aldehydes Journal of Organic Chemistry  1990 55:4117-4126  DOI:10.1021/jo00300a032
    • Roush, W. R., Hoong, L. K., Palmer, M. A. J., Park, J. C. Asymmetric synthesis using tartrate ester modified allylboronates.1. Factors influencing stereoselectivity Journal of Organic Chemistry  1990 55:4109-4117  DOI:10.1021/jo00300a031
    • Roush, W. R., Park, J. C. Use of metal carbonyl complexes to achieve high enantioselectivity in the asymmetric allylboration of unsaturated aldehydes Journal of Organic Chemistry  1990 55:1143-1144  DOI:10.1021/jo00291a009
    • Roush, W. R., Park, J. C. Asymmetric allylborations of diene aldehyde Fe(CO)3 derivatives: efficient kinetic resolution of racemic complexes and the highly enantiotopic group and face selective allylboration of a meso substrate Tetrahedron Letters  1990 31:4707-4710  DOI:10.1016/s0040-4039(00)97712-8
    • Roush, W. R., Grover, P. T. Diisopropyl tartrate (E)-γ-(dimethylphenylsilyl)allylboronate, a chiral allylic alcohol β-carbanion equivalent for the enantioselective synthesis of 2-butene-1,4-diols from aldehydes Tetrahedron Letters  1990 31:7567-7570  DOI:10.1016/s0040-4039(00)97300-3
    • Roush, W. R., Grover, P. T., Lin, X. F. Diisopropyl tartrate modified (E)-γ-[(cyclohexyloxy)dimethylsilyl-allylboronate, a chiral reagent for the stereoselective synthesis of anti 1,2-diols via the formal α-hydroxyallylation of aldehydes Tetrahedron Letters  1990 31:7563-7566  DOI:10.1016/s0040-4039(00)97299-x
    • Roush, W. R. Stereochemical and synthetic studies of the intramolecular Diels-Alder reaction Advances in Cycloaddition  1990 2:91-146
    • Roush, W. R., Moriarty, K. J., Brown, B. B. Stereoselective synthesis of (Z,E)-2-bromo-1,3-dienes via the palladium (O) catalyzed cross coupling reactions of 1,1-dibromoolefins and vinylboronic acids Tetrahedron Letters  1990 31:6509-6512  DOI:10.1016/s0040-4039(00)97103-x
    • Roush, W. R., Palkowitz, A. D. Synthesis of the C(1)-C(15) segment of streptovaricin D Journal of Organic Chemistry  1989 54:3009-3011  DOI:10.1021/jo00274a008
    • Roush, W. R., Michaelides, M. R., Tai, D. F., Lesur, B. M., Chong, W. K. M., Harris, D. J. A highly stereoselective synthesis of (+)-olivin, the aglycon of olivomycin A Journal of the American Chemical Society  1989 111:2984-2995  DOI:10.1021/ja00190a036
    • Coe, J. W., Roush, W. R. Studies of an intramolecular Diels-Alder approach to the nargenicins: involvement of boatlike transition states in the cyclizations of substituted 1,7,9-decatrien-3-ones Journal of Organic Chemistry  1989 54:915-930  DOI:10.1021/jo00265a036
    • Roush, W. R. Applications of allylboronates in the synthesis of carbohydrates and polyhydroxylated natural products ACS Symposium Series  1989 386:242-277  DOI:10.1021/bk-1989-0386.ch014
    • Roush, W. R., Brown, B. B. Diastereoselective synthesis of the top half of kijanolide Tetrahedron Letters  1989 30:7309-7312  DOI:10.1016/s0040-4039(00)70684-8
    • Roush, W. R. Evolution of a strategy for the synthesis of olivomycin A: development of methodology for the diastereo- and enantioselective synthesis of carbohydrates from acyclic precursors Strategies and Tactics in Organic Synthesis  1989 323-367
    • Roush, W. R., Essenfeld, A. P., Warmus, J. S., Brown, B. B. Synthesis and Diels-Alder reactions of 2-alkyl-5-methylene-1,3-dioxolan-4-ones and 2-alkyl-3-acyl-5-methylene-1,3-oxazolidin-4-ones: highly exo and diastereoface selective chiral ketene equivalents Tetrahedron Letters  1989 30:7305-7308  DOI:10.1016/s0040-4039(00)70683-6
    • Roush, W. R., Banfi, L., Park, J. C., Hoong, L. K. The asymmetric allylboration reaction: dependence of rate and enantioselectivity on the chiral auxiliary Tetrahedron Letters  1989 30:6457-6460  DOI:10.1016/s0040-4039(01)88993-0
    • Roush, W. R., Banfi, L. N,N'-dibenzyl-N,N'-ethylenetartramide: a rationally designed chiral auxiliary for the allylboration reaction Journal of the American Chemical Society  1988 110:3979-3982  DOI:10.1021/ja00220a041
    • Roush, W. R., Riva, R. Enantioselective synthesis of the bottom half of chlorothricolide. 2. A comparative study of substituent effects on the stereoselectivity of the key intramolecular Diels-Alder reaction Journal of Organic Chemistry  1988 53:710-712  DOI:10.1021/jo00238a049
    • Roush, W. R., Brown, B. B., Drozda, S. E. A highly stereoselective synthesis of the octahydronaphthalene subunit of kijanolide and tetronolide Tetrahedron Letters  1988 29:3541-3544  DOI:10.1016/0040-4039(88)85287-0
    • Roush, W. R., Ando, K., Powers, D. B., Halterman, R. L., Palkowitz, A. D. Enantioselective synthesis using diisopropyl tartrate modified (E)- and (Z)-crotylboronates: reactions with achiral aldehydes Tetrahedron Letters  1988 29:5579-5582  DOI:10.1016/s0040-4039(00)80816-3
    • Roush, W. R., Michaelides, M. R., Tai, D. F., Chong, W. K. M. A highly stereoselective total synthesis of the natural enantiomer of olivin Journal of the American Chemical Society  1987 109:7575-7577  DOI:10.1021/ja00258a077
    • Halterman, R. L., Roush, W. R., Hoong, L. K. Analytical resolution of secondary methyl ethers by chiral complexation gas chromatography Journal of Organic Chemistry  1987 52:1152-1155  DOI:10.1021/jo00382a036
    • Roush, W. R., Palkowitz, A. D. Applications of tartrate ester modified allylic boronates in organic-synthesis: an efficient, highly stereoselective synthesis of the C19-C29 segment of rifamycin S Journal of the American Chemical Society  1987 109:953-955  DOI:10.1021/ja00237a082
    • Roush, W. R., Palkowitz, A. D., Palmer, M. A. J. Reactions of diisopropyl tartrate modified allyl- and (E)- and (Z)-crotylboronates with beta-alkoxy-alpha-methylpropionaldehydes: a reagent-based solution to the acyclic dipropionate problem Journal of Organic Chemistry  1987 52:316-318  DOI:10.1021/jo00378a041
    • Roush, W. R., Essenfeld, A. P., Warmus, J. S. Effect of dienophile activating group on the stereoselectivity of the intramolecular Diels-Alder reaction Tetrahedron Letters  1987 28:2447-2450  DOI:10.1016/s0040-4039(00)95437-6
    • Roush, W. R., Coe, J. W. Studies on the synthesis of nargenicin A(1). An example of anintramolecular Diels-Alder reaction that proceeds with a boat-likeconformation of the connecting chain Tetrahedron Letters  1987 28:931-934  DOI:10.1016/s0040-4039(00)95877-5
    • Roush, W. R., Straub, J. A., Brown, R. J. Total synthesis of carbohydrates. 5. Stereochemistry of the epoxidations of acyclic allylic amides. Applications towards the synthesis of 2,3,6-trideoxy-3-aminohexoses Journal of Organic Chemistry  1987 52:5127-5136  DOI:10.1021/jo00232a014
    • Roush, W. R., Russorodriguez, S. Trichothecene degradation studies. 2. Synthesis of [13-(14)-C] anguidine Journal of Organic Chemistry  1987 52:598-603  DOI:10.1021/jo00380a021
    • Roush, W. R., Russorodriguez, S. Trichothecene degradation studies. 3. Synthesis of 12,13-deoxy-12,13-methanoanguidine and 12-epianguidine, two optically active analogs of the epoxytrichothecene mycotoxin anguidine Journal of Organic Chemistry  1987 52:603-606  DOI:10.1021/jo00380a022
    • Roush, W. R., Adam, M. A., Walts, A. E., Harris, D. J. Stereochemistry of the reactions of substituted allylboronates with chiral aldehydes: factors influencing aldehyde diastereofacial selectivity Journal of the American Chemical Society  1986 108:3422-3434  DOI:10.1021/ja00272a043
    • Roush, W. R., Halterman, R. L. Diisopropyl tartrate modified (E)-crotylboronates: highly enantioselective propionate (E)-enolate equivalents Journal of the American Chemical Society  1986 108:294-296  DOI:10.1021/ja00262a018
    • Roush, W. R., Michaelides, M. R. Studies on the total synthesis of sesbanimide: highly diastereoselective synthesis of the AB ring system Tetrahedron Letters  1986 27:3353-3356  DOI:10.1016/s0040-4039(00)84794-2
    • Roush, W. R., Straub, J. A. Total synthesis of the AB disaccharide unit of olivomycin A Tetrahedron Letters  1986 27:3349-3352  DOI:10.1016/s0040-4039(00)84793-0
    • Roush, W. R., Russorodriguez, S. Trichothecene degradation studies: synthesis of 12,13-deoxyanguidine and 12,13-deoxyverrucarol Journal of Organic Chemistry  1985 50:5465-5468  DOI:10.1021/jo00350a004
    • Roush, W. R., Walts, A. E., Hoong, L. K. Diastereoselective and enantioselective aldehyde addition-reactions of 2-allyl-1,3,2-dioxaborolane-4,5-dicarboxylic esters, a useful class of tartrate ester modified allylboronates Journal of the American Chemical Society  1985 107:8186-8190  DOI:10.1021/ja00312a062
    • Walts, A. E., Roush, W. R. A stereorational total synthesis of (-)-ptilocaulin Tetrahedron  1985 41:3463-3478  DOI:10.1016/s0040-4020(01)96701-8
    • Roush, W. R., Adam, M. A. Directed openings of 2,3-epoxy alcohols via reactions with isocyanates: synthesis of (+)-erythro-dihydrosphingosine Journal of Organic Chemistry  1985 50:3752-3757  DOI:10.1021/jo00220a015
    • Roush, W. R., Kageyama, M. Enantioselective synthesis of the bottom half of chlorothricolide Tetrahedron Letters  1985 26:4327-4330  DOI:10.1016/s0040-4039(00)98725-2
    • Roush, W. R., Adam, M. A., Harris, D. J. Stereochemistry of crotylboronate additions to alpha,beta-dialkoxy aldehydes Journal of Organic Chemistry  1985 50:2000-2003  DOI:10.1021/jo00211a051
    • Roush, W. R., Walts, A. E. Stereochemistry of the reactions of pinacol allylboronate with two α,β-dialkoxyaldehydes Tetrahedron Letters  1985 26:3427-3430  DOI:10.1016/s0040-4039(00)98655-6
    • Roush, W. R., Russorodriguez, S. Synthesis of 4-beta-acetoxyscirpene-3-alpha,15-diol Journal of Organic Chemistry  1985 50:3224-3226  DOI:10.1021/jo00217a046
    • Roush, W. R., Hagadorn, S. M. Synthesis of mycarose and epi-axenose from non-carbohydrate precursors Carbohydrate Research  1985 136:187-193  DOI:10.1016/0008-6215(85)85195-8  PMID:4005889
    • Roush, W. R., Marletta, M. A., Russo-Rodriguez, S., Recchia, J. Trichothecene metabolism studies. 2. Structure of 3α-​(1'β-​D-​glucopyranosiduronyl)​-​8α-​isovaleryloxyscirpen-​3,​4β,​15-​triol 15-​acetate produced from T-​2 toxin in vitro Tetrahedron Letters  1985 26:5231-5234  DOI:10.1016/S0040-4039(00)95002-0
    • Roush, W. R., Marletta, M. A., Russo-Rodriguez, S., Recchia, J. Trichothecene metabolism studies: isolation and structure determination of 15-​acetyl-​3α-​(1'β-​D-​glucopyranosiduronyl)​scirpen-​3,​4β,​15-​triol Journal of the American Chemical Society  1985 107:3354-3355  DOI:10.1021/ja00297a055
    • Blanchette, M. A., Choy, W., Davis, J. T., Essenfeld, A. P., Masamune, S., Roush, W. R., Sakai, T. Horner-Wadsworth-Emmons reaction: use of lithium chloride and an amine for base-sensitive compounds Tetrahedron Letters  1984 25:2183-2186  DOI:10.1016/s0040-4039(01)80205-7
    • Roush, W. R., Gillis, H. R., Essenfeld, A. P. Hydrofluoric acid catalyzed intramolecular Diels-Alder reactions Journal of Organic Chemistry  1984 49:4674-4682  DOI:10.1021/jo00198a018
    • Roush, W. R., Peseckis, S. M., Walts, A. E. Synthesis of antibiotic X-14547A Journal of Organic Chemistry  1984 49:3429-3432  DOI:10.1021/jo00192a052
    • Roush, W. R., Blizzard, T. A. Synthesis of epoxytrichothecenes: verrucarin J and verrucarin J isomers Journal of Organic Chemistry  1984 49:1772-1783  DOI:10.1021/jo00184a021
    • Roush, W. R., Blizzard, T. A. Synthesis of verrucarin B Journal of Organic Chemistry  1984 49:4332-4339  DOI:10.1021/jo00197a002
    • Roush, W. R., Walts, A. E. Total synthesis of (-)-ptilocaulin Journal of the American Chemical Society  1984 106:721-723  DOI:10.1021/ja00315a044
    • Roush, W. R., Adam, M. A., Peseckis, S. M. Regioselectivity of the reactions of trialkylaluminum reagents with 2,3-epoxyalcohols: application to the synthesis of α-chiral aldehydes Tetrahedron Letters  1983 24:1377-1380  DOI:10.1016/s0040-4039(00)81660-3
    • Roush, W. R., Lesur, B. M. Stereochemistry of vinyl cuprate additions to carbohydrate-derived enones and α,β-unsaturated esters Tetrahedron Letters  1983 24:2231-2234  DOI:10.1016/s0040-4039(00)81891-2
    • Roush, W. R., Harris, D. J., Lesur, B. M. Studies on the synthesis of olivin: diastereoselective synthesis of a functionalized D-fucose derivative Tetrahedron Letters  1983 24:2227-2230  DOI:10.1016/s0040-4039(00)81890-0
    • Roush, W. R., Spada, A. P. Synthesis of trichoverrol B Tetrahedron Letters  1983 24:3693-3696  DOI:10.1016/s0040-4039(00)94511-8
    • Roush, W. R., Blizzard, T. A. Synthesis of verrucarin J Journal of Organic Chemistry  1983 48:758-759  DOI:10.1021/jo00153a035
    • Roush, W. R., Dambra, T. E. Total synthesis of (+/-)-verrucarol Journal of the American Chemical Society  1983 105:1058-1060  DOI:10.1021/ja00342a071
    • Roush, W. R., Brown, R. J., Dimare, M. Total synthesis of carbohydrates. 2. Regiochemical control of nucleophilic ring opening of acylated 2,3-epoxy alcohols Journal of Organic Chemistry  1983 48:5083-5093  DOI:10.1021/jo00173a056
    • Roush, W. R., Brown, R. J. Total synthesis of carbohydrates. 3. Efficient enantioselective syntheses of 2,6-dideoxyhexoses Journal of Organic Chemistry  1983 48:5093-5101  DOI:10.1021/jo00173a057
    • Roush, W. R., Spada, A. P. Enantioselective and stereoselective syntheses of the dihydroxyoctadienoic acid fragments of the roridins and trichoverrins Tetrahedron Letters  1982 23:3773-3776  DOI:10.1016/s0040-4039(00)87703-5
    • Roush, W. R., Gillis, H. R. Further stereochemical aspects of intramolecular Diels-Ader reactions in the undeca-2,8,10-trienoate ester series Journal of Organic Chemistry  1982 47:4825-4829  DOI:10.1021/jo00146a001
    • Roush, W. R., Blizzard, T. A., Basha, F. Z. Methodology for the synthesis of the acyclic portions of verrucarins A and J Tetrahedron Letters  1982 23:2331-2334  DOI:10.1016/s0040-4039(00)87334-7
    • Roush, W. R., Gillis, H. R., Ko, A. I. Stereochemical aspects of the intramolecular Diels-Alder reactions of deca-2,7,9-trienoate esters. 3. Thermal, Lewis acid-catalyzed, and asymmetric cyclizations Journal of the American Chemical Society  1982 104:2269-2283  DOI:10.1021/ja00372a027
    • Roush, W. R., Peseckis, S. M. Studies on the total synthesis of antibiotic X-14547A: the pentaene approach Tetrahedron Letters  1982 23:4879-4882  DOI:10.1016/s0040-4039(00)85737-8
    • Hall, S. E., Roush, W. R. Synthesis of the bottom half of chlorothricolide Journal of Organic Chemistry  1982 47:4611-4621  DOI:10.1021/jo00145a002
    • Roush, W. R., Brown, R. J. Total synthesis of carbohydrates: stereoselective syntheses of 2,6-dideoxy-D-arabino-hexose and 2,6-dideoxy-D-ribo-hexose Journal of Organic Chemistry  1982 47:1371-1373  DOI:10.1021/jo00346a050
    • Roush, W. R., Myers, A. G. Antibiotic X-14547A: total synthesis of the right-hand half Journal of Organic Chemistry  1981 46:1509-1511  DOI:10.1021/jo00320a060
    • Roush, W. R., Peseckis, S. M. Intramolecular Diels-Alder reactions: the angularly methylated trans-perhydroindan ring system Journal of the American Chemical Society  1981 103:6696-6704  DOI:10.1021/ja00412a027
    • Roush, W. R., Hall, S. E. Studies on the total synthesis of chlorothricolide: stereochemical aspects of the intramolecular Diels-Alder reactions of methyl undeca-2,8,10-trienoates Journal of the American Chemical Society  1981 103:5200-5211  DOI:10.1021/ja00407a042
    • Roush, W. R., Dambra, T. E. Synthesis of a bicyclic precursor to verrucarol: application of a trimethylsilyl-controlled Diels-Alder reaction and Wagner-Meerwein rearrangement sequence Journal of Organic Chemistry  1981 46:5045-5047  DOI:10.1021/jo00337a059
    • Roush, W. R., Gillis, H. R. Improved synthesis of the perhydroindenone precursor of dendrobine Journal of Organic Chemistry  1980 45:4283-4287  DOI:10.1021/jo01310a006
    • Roush, W. R., Ko, A. I., Gillis, H. R. Stereochemical aspects of the intramolecular Diels-Alder reactions of methyl deca-2,7,9-trienoates. 1. Thermal cyclizations Journal of Organic Chemistry  1980 45:4264-4267  DOI:10.1021/jo01309a054
    • Roush, W. R., Gillis, H. R., Hall, S. E. Stereoselective syntheses of substituted methyl (Z,E,E)-deca-2,7.9-trienoates and substituted methyl (Z,E,E)-undeca-2,8,10-trienoates Tetrahedron Letters  1980 21:1023-1026  DOI:10.1016/s0040-4039(00)78829-0
    • Roush, W. R. Total synthesis of (+/-)-dendrobine Journal of the American Chemical Society  1980 102:1390-1404  DOI:10.1021/ja00524a027
    • Roush, W. R., Dambra, T. E. Total synthesis of verrucarol: a stereoselective synthesis of 13,14-dinor-15-hydroxytrichothec-9-ene Journal of Organic Chemistry  1980 45:3927-3929  DOI:10.1021/jo01307a045
    • Roush, W. R. Stereochemical aspects of the intramolecular Diels-Alder reactions of methyl (E,E,E)- and (Z,E,E)-6-alkoxy-11-methyldodeca-2,7,9-trienoate Journal of Organic Chemistry  1979 44:4008-4010  DOI:10.1021/jo01336a067
    • Roush, W. R. Total synthesis of (+/-)-dendrobine Journal of the American Chemical Society  1978 100:3599-3601  DOI:10.1021/ja00479a053
    • Roush, W. R., Feitler, D., Rebek, J. Polymer-bound tosyl azide Tetrahedron Letters  1974 1391-1392  DOI:10.1016/S0040-4039(01)82499-0
  • chapter

    • Nanna, A. R., Roush, W. R., Rader, C. Chemical assembly of antibody-drug conjugates Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins. 1-28. 2017
  • report

    • Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Allais, C., Ouizem, S., Saldanha, S. A., Ferguson, J., Mercer, B. A., Michael, C., et al. ML346: A novel modulator of proteostasis for protein conformational diseases 2010
    • Minond, D., Saldanha, S. A., Spicer, T., Qin, L., Mercer, B. A., Roush, W. R., Hodder, P. HTS assay for discovery of novel metallo-beta-lactamase (MBL) inhibitors Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21961119
    • Busby, S., Nuhant, P., Cameron, M., Mercer, B. A., Hodder, P., Roush, W. R., Griffin, P. R. Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2) 2010
    • Kumar, N., Nuhant, P., Solt, L. A., Conkright, J. J., Wang, Y., Istrate, M. A., Busby, S. A., Ruben, D. G. O., Burris, T. P., Cameron, M., Mercer, B. A., Hodder, P., et al. Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORalpha) 2010
    • Simanski, S., Madoux, F., Rahaim, R. J., Chase, P., Schurer, S., Cameron, M., Mercer, B. A., Hodder, P., Roush, W. R., Ayad, N. G. Identification of small molecule inhibitors of Wee1 degradation and mitotic entry 2010
    • Kota, S., Madoux, F., Chase, P., Takahashi, V., Liu, Q., Mercer, B. A., Cameron, M., Strosberg, A. D., Roush, W., Hodder, P. ML322, a small molecule inhibitor of dimerization of the core protein of hepatitis C virus (HCV) 2010
    • Cameron, M., Kamenecka, T., Madoux, F., Chase, P., Roush, W., Hodder, P., Griffin, P. R. ML368 identification of imidazopyridines as selective inhibitors of the cytochrome P450 enzyme CYP3A4 2010
    • Spicer, T., Minond, D., Enogieru, I., Saldanha, S. A., Allais, C., Liu, Q., Mercer, B. A., Roush, W. R., Hodder, P. ML302, a novel beta-lactamase (BLA) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762954
  • thesis

    • A synthetic approach to dendrobine 1977

featured in

  • Mixing Basic and Applied Research: An Interview with John Cleveland  Newsletter
  • Renowned University of Michigan Chemist Joins Scripps Florida Faculty  News Release
  • Scripps Florida Scientists Awarded $1.4 Million to Develop New Therapeutic Approaches to Chronic Leukemia  News Release
  • Scripps Florida Scientists Awarded $1.5 Million to Fight Major Water and Food Parasites  News Release
  • Scripps Florida Scientists Share $3.85 Million NIH Grant to Develop New Class of Cancer Therapies  News Release
  • Scripps Research Scientist Wins Pair of Grants to Study Critical Component of Memory  News Release
  • Scripps Research Scientists Develop Compound that Effectively Halts Progression of Multiple Sclerosis  News Release
  • Scripps Research Scientists Share $2 Million in Florida State Research Grants  News Release
scroll to property group menus

Research

research overview

  • The major focus of our research effort concerns the synthesis of stereochemically complex, biologically active natural products. Natural products of considerable current interest include (among others): durhamycin A and B, members of the aureolic acid antibiotic family; angelimicin B, a signal transduction pathway inhibitor; tedanolide, scytophycin C, apoptolidin, and superstolide A -- four structurally complex macrolide antibiotics; quartromicin D, an antiviral agent; and various members of the amphidinolide and Annonaceous acetogenin families. Significant emphasis is placed on the discovery, development, and/or illustration of new reactions and synthetic methods in this research. Some of these synthesis projects involve intramolecular cycloaddition reactions. Others make use of acyclic diastereoselective or enantioselective stereochemical techniques. Still others focus on the development and illustration of new methods for synthesis of glycosides.

    We are also pursuing several research programs in bioorganic chemistry, including one focusing on the design and synthesis of inhibitors of cysteine proteases isolated from tropical parasites. This project is performed in collaboration with several groups of scientists at the University of California, San Francisco.
scroll to property group menus

Teaching

teaching activities

  • Asymmetric Sythesis - AS113 Course Director

advisees

  • graduate advising relationship

    • Nilchan, Napon, Ph.D.  candidate, 2015 - 2019
    • Alburger, James, Ph.D.  candidate, 2014 - 2018
    • Nanna, Alex, Ph.D.  candidate, 2014 - 2018
    • El Hilali, Xochina, Ph.D.  candidate, 2012 - 2017
    • Mason, Jeremy William, Ph.D.  candidate, 2013 - 2017
    • Wood, Spencer Donald, Ph.D.  candidate, 2013 - 2017
    • Pedzisa, Lee, Ph.D.  candidate, 2010 - 2016
    • Stowe, Ryan Lee, Ph.D.  candidate, 2011 - 2016
    • Ying, Maben, Ph.D.  candidate, 2009 - 2015
    • Abbott, Jason, Ph.D.  candidate, 2009 - 2014
    • Chen, Ming, Ph.D.  candidate, 2008 - 2012
    • Halvorsen, Geoff, Ph.D.  candidate, 2005 - 2012
    • Whitaker, John, Ph.D.  candidate, 2007 - 2012
    • Nguyen, Christine P, Ph.D.  candidate, 2004 - 2010
    • Winbush, SusAnn, Ph.D.  candidate, 2005 - 2010
    • Bates, Robert, Ph.D.  candidate, 2006 - 2009
    • Huh, Chan-Woo, Ph.D.  candidate, 2003 - 2008
    • Lira, Ricardo, Ph.D.  candidate, 2005 - 2008
    • Pragani, Rajan, Ph.D.  candidate, 2004 - 2008
    • Va, Porino Jinjo, Ph.D.  candidate, 2005 - 2007
  • postdoc or fellow advising relationship

    • Halvorsen, Geoff, Ph.D.  candidate, 2012 - 2015
scroll to property group menus

Background

education and training

  • Ph.D. in Chemistry, Harvard University 1977
  • B.S. in Chemistry, University of California, Los Angeles , summa cum laude 1974

awards and honors

  • Fellow of the American Academy of Arts and Sciences, conferred by American Academy of Arts & Sciences, 2006
scroll to property group menus

Contact

full name

  • William R. Roush

geographic location

  • Scripps Florida 

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support