recent publications
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academic article
- Nilchan, N., Alburger, J. M., Roush, W. R., Rader, C. An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation Biochemistry 2021 60:1080-1087 DOI:10.1021/acs.biochem.0c00955 PMID:33754696
- Lo, C. H., Shay, G., McGuire, J. J., Li, T., Shain, K. H., Choi, J. Y., Fuerst, R., Roush, W. R., Knapinska, A. M., Fields, G. B., Lynch, C. C. Host-Derived Matrix Metalloproteinase-13 Activity Promotes Multiple Myeloma-Induced Osteolysis and Reduces Overall Survival Cancer Research 2021 81:2415-2428 DOI:10.1158/0008-5472.Can-20-2705 PMID:33526510
- Jilkova, A., Rubesova, P., Fanfrlik, J., Fajtova, P., Rezacova, P., Brynda, J., Lepsik, M., Mertlikova-Kaiserova, H., Emal, C. D., Renslo, A. R., Roush, W. R., Horn, M., et al. Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors Acs Infectious Diseases 2020 7:1077-1088 DOI:10.1021/acsinfecdis.0c00501 PMID:33175511 PMCID:PMC8154419
- Vena, F., Bayle, S., Nieto, A., Quereda, V., Aceti, M., Frydman, S. M., Sansil, S. S., Grant, W., Monastyrskyi, A., McDonald, P., Roush, W. R., Teng, M. X., et al. Targeting Casein Kinase 1 Delta Sensitizes Pancreatic and Bladder Cancer Cells to Gemcitabine Treatment by Upregulating Deoxycytidine Kinase Molecular Cancer Therapeutics 2020 19:1623-1635 DOI:10.1158/1535-7163.Mct-19-0997 PMID:32430484 PMCID:PMC7415672
- Maharaj, K., Powers, J. J., Achille, A., Mediavilla-Varela, M., Gamal, W., Burger, K. L., Fonseca, R., Jiang, K., Miskin, H. P., Maryanski, D., Monastyrskyi, A., Duckett, D. R., et al. The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells Blood Advances 2020 4:3072-3084 DOI:10.1182/bloodadvances.2020001800 PMID:32634240 PMCID:PMC7362385
- Quereda, V., Bayle, S., Vena, F., Frydman, S. M., Monastyrskyi, A., Roush, W. R., Duckett, D. R. Therapeutic targeting of CDK12/CDK13 in triple-negative breast cancer Cancer Cell 2019 36:545-558 DOI:10.1016/j.ccell.2019.09.004 PMID:31668947
- Renner, K., Bruss, C., Schnell, A., Koehl, G., Becker, H. M., Fante, M., Menevse, A. N., Kauer, N., Blazquez, R., Hacker, L., Decking, S. M., Bohn, T., et al. Restricting glycolysis preserves T cell effector functions and augments checkpoint therapy Cell Reports 2019 29:135-150 DOI:10.1016/j.celrep.2019.08.068 PMID:31577944
- Hwang, D.*, Nilchan, N.*, Nanna, A. R., Li, X., Cameron, M. D., Roush, W. R., Park, H., Rader, C. Site-selective antibody functionalization via orthogonally reactive arginine and lysine residues Cell Chemical Biology 2019 26:1229-1239 DOI:10.1016/j.chembiol.2019.05.010 PMID:31231031 PMCID:PMC6754284 (* = equal contribution)
- Doebelin, C., He, Y., Campbell, S., Nuhant, P., Kumar, N., Koenig, M., Garcia-Ordonez, R., Chang, M. R., Roush, W. R., Lin, L., Kahn, S., Cameron, M. D., et al. Discovery and optimization of a series of sulfonamide inverse agonists for the retinoic acid receptor-related orphan receptor-α Medicinal Chemistry 2019 15:676-684 DOI:10.2174/1573406415666190222124745 PMID:30799793
- Fuerst, R., Yong Choi, J., Knapinska, A. M., Smith, L., Cameron, M. D., Ruiz, C., Fields, G. B., Roush, W. R. Development of matrix metalloproteinase-13 inhibitors - A structureactivity/structure-property relationship study Bioorganic & Medicinal Chemistry 2018 26:4984-4995 DOI:10.1016/j.bmc.2018.08.020 PMID:30249495
- Persi, E., Duran-Frigola, M., Damaghi, M., Roush, W. R., Aloy, P., Cleveland, J. L., Gillies, R. J., Ruppin, E. Systems analysis of intracellular pH vulnerabilities for cancer therapy Nature Communications 2018 9 DOI:10.1038/s41467-018-05261-x PMID:30065243 PMCID:PMC6068141
- Zyserman, I., Mondal, D., Sarabia, F., McKerrow, J. H., Roush, W. R., Debnath, A. Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri Experimental Parasitology 2018 188:36-41 DOI:10.1016/j.exppara.2018.03.010 PMID:29551628 PMCID:PMC5918159
- Monastyrskyi, A., Nilchan, N., Quereda, V., Noguchi, Y., Ruiz, C., Grant, W., Cameron, M., Duckett, D., Roush, W. Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer Bioorganic & Medicinal Chemistry 2018 26:590-602 DOI:10.1016/j.bmc.2017.12.020 PMID:29289448 PMCID:PMC5803353
- Monastyrskyi, A., Bayle, S., Quereda, V., Grant, W., Cameron, M., Duckett, D., Roush, W. Discovery of 2-arylquinazoline derivatives as a new class of ASK1 inhibitors Bioorganic & Medicinal Chemistry Letters 2018 28:400-404 DOI:10.1016/j.bmcl.2017.12.026 PMID:29277458
- Wood, S. D., Grant, W., Adrados, I., Choi, J. Y., Alburger, J. M., Duckett, D. R., Roush, W. R. In silica HTS and structure based optimization of indazole-derived ULK1 inhibitors ACS Medicinal Chemistry Letters 2017 8:1258-1263 DOI:10.1021/acsmedchemlett.7b00344 PMID:29259744 PMCID:PMC5733266
- Rondini, E. A., Mladenovic-Lucas, L., Roush, W. R., Halvorsen, G. T., Green, A. E., Granneman, J. G. Novel pharmacological probes reveal ABHD5 as a locus of lipolysis control in white and brown adipocytess Journal of Pharmacology and Experimental Therapeutics 2017 363:367-376 DOI:10.1124/jpet.117.243253 PMID:28928121 PMCID:PMC5698943
- Nanna, A. R., Li, X., Walseng, E., Pedzisa, L., Goydel, R. S., Hymel, D., Burke, T. R., Roush, W. R., Rader, C. Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates Nature Communications 2017 8 DOI:10.1038/s41467-017-01257-1 PMID:29062027 PMCID:PMC5653646
- Choi, J. Y., Fuerst, R., Knapinska, A. M., Taylor, A. B., Smith, L., Cao, X., Hart, P. J., Fields, G. B., Roush, W. R. Structure-based design and synthesis of potent and selective matrix metalloproteinase 13 inhibitors Journal of Medicinal Chemistry 2017 60:5816-5825 DOI:10.1021/acs.jmedchem.7b00514 PMID:28653849
- Allais, C., Roush, W. R. Enantio- and diastereoselective synthesis of 1,5-syn-(Z)-amino alcohols via imine double allylboration: Synthesis of trans-1,2,3,6-tetrahydropyridines and total synthesis of andrachcine Organic Letters 2017 19:2646-2649 DOI:10.1021/acs.orglett.7b00995 PMID:28471668
- Bhowmick, M., Tokmina-Roszyk, D., Onwuha-Ekpete, L., Harmon, K., Robichaud, T., Fuerst, R., Stawikowska, R., Steffensen, B., Roush, W., Wong, H. R., Fields, G. B. Second generation triple-helical peptide inhibitors of matrix metalloproteinases Journal of Medicinal Chemistry 2017 60:3814-3827 DOI:10.1021/acs.jmedchem.7b00018 PMID:28394608
- Mason, J. W., Schmid, C. L., Bohn, L. M., Roush, W. R. Stolonidiol: Synthesis, target identification, and mechanism for choline acetyltransferase activation Journal of the American Chemical Society 2017 139:5865-5869 DOI:10.1021/jacs.7b01083 PMID:28414442
- Getun, I. V., Wu, Z., Fallahi, M., Ouizem, S., Liu, Q., Li, W., Costi, R., Roush, W. R., Cleveland, J. L., Bois, P. R. J. Functional roles of acetylated histone marks at mouse meiotic recombination hot spots Molecular and Cellular Biology 2017 37:UNSP e00942-15 DOI:10.1128/mcb.00942-15 PMID:27821479 PMCID:PMC5247613
- Calvet, C. M., Choi, J. Y., Thomas, D., Suzuki, B., Hirata, K., Lostracco-Johnson, S., de Mesquita, L. B., Nogueira, A., Meuser-Batista, M., Silva, T. A., Siqueira-Neto, J. L., Roush, W. R., et al. 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection PLoS Neglected Tropical Diseases 2017 11 DOI:10.1371/journal.pntd.0006132 PMID:29281643 PMCID:PMC5744913
- Choi, J. Y., Roush, W. R. Structure Based Design of CYP51 Inhibitors Current Topics in Medicinal Chemistry 2017 17:30-39 DOI:10.2174/1568026616666160719164933 PMID:27449014
- Patterson, J. T., Wilson, H. D., Asano, S., Nilchan, N., Fuller, R. P., Roush, W. R., Rader, C., Barbas III, C. F. Human serum albumin domain I fusion protein for antibody conjugation Bioconjugate Chemistry 2016 27:2271-2275 DOI:10.1021/acs.bioconjchem.6b00432 PMID:27666414
- Walseng, E., Nelson, C. G., Qi, J., Nanna, A. R., Roush, W. R., Goswami, R. K., Sinha, S. C., Burke Jr., T. R., Rader, C. Chemically programmed bispecific antibodies in diabody format Journal of Biological Chemistry 2016 291:19661-19673 DOI:10.1074/jbc.M116.745588 PMID:27445334 PMCID:PMC5016699
- Ewing, H., Fernandez-Vega, V., Spicer, T. P., Chase, P., Brown, S., Scampavia, L., Roush, W. R., Riley, S., Rosen, H., Hodder, P., Lambeau, G., Gelb, M. H. Fluorometric high-throughput screening assay for secreted phospholipases A(2) using phospholipid vesicles Journal of Biomolecular Screening 2016 21:713-721 DOI:10.1177/1087057116646742 PMID:27146384
- Pedzisa, L., Li, X., Rader, C., Roush, W. R. Assessment of reagents for selenocysteine conjugation and the stability of selenocysteine adducts Organic & Biomolecular Chemistry 2016 14:5141-5147 DOI:10.1039/c6ob00775a PMID:27184239 PMCID:PMC4887430
- Nair, R. N., Mishra, J. K., Li, F., Tortosa, M., Yang, C., Doherty, J. R., Cameron, M., Cleveland, J. L., Roush, W. R., Bannister, T. D. Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors MedChemComm 2016 7:900-905 DOI:10.1039/c5md00579e PMID:27347360
- Jones, B. D., Tochowicz, A., Tang, Y., Cameron, M. D., McCall, L. I., Hirata, K., Siqueira-Neto, J. L., Reed, S. L., McKerrow, J. H., Roush, W. R. Synthesis and evaluation of oxyguanidine analogues of the cysteine protease inhibitor WRR-483 against cruzain ACS Medicinal Chemistry Letters 2016 7:77-82 DOI:10.1021/acsmedchemlett.5600336 PMID:26819670 PMCID:PMC4716606
- Rosenberg, L. H., Lafitte, M., Quereda, V., Grant, W., Chen, W., Bibian, M., Noguchi, Y., Fallahi, M., Yang, C., Chang, J. C., Roush, W. R., Cleveland, J. L., et al. Therapeutic targeting of casein kinase 1δ in breast cancer Science Translational Medicine 2015 7:318ra202 DOI:10.1126/scitranslmed.aac8773 PMID:26676609 PMCID:PMC4809734
- Sanders, M. A., Madoux, F., Mladenovic, L., Zhang, H., Ye, X., Angrish, M., Mottillo, E. P., Caruso, J. A., Halvorsen, G., Roush, W. R., Chase, P., Hodder, P., et al. Endogenous and synthetic ABHD5 ligands regulate ABHD5-perilipin interactions and lipolysis in fat and muscle Cell Metabolism 2015 22:851-860 DOI:10.1016/j.cmet.2015.08.023 PMID:26411340 PMCID:PMC4862007
- Li, X., Patterson, J. T., Sarkar, M., Pedzisa, L., Kodadek, T., Roush, W. R., Rader, C. Site-specific dual antibody conjugation via engineered cysteine and selenocysteine residues Bioconjugate Chemistry 2015 26:2243-2248 DOI:10.1021/acs.bioconjchem.5600244 PMID:26161903
- Schreiber, S. L., Kotz, J. D., Li, M., Aube, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., et al. Advancing biological understanding and therapeutics discovery with small-molecule probes Cell 2015 161:1252-1265 DOI:10.1016/j.cell.2015.05.023 PMID:26046436 PMCID:PMC4564295
- El Hilali, X., Roush, W. R. Enantio- and diastereoselective synthesis of syn-β-hydroxy-α-alkenyl carboxamides via reductive aldol reactions of morpholine 4-methyl-2,3-pentadienoic carboxamide with diisopinocampheylborane Tetrahedron Letters 2015 56:3281-3284 DOI:10.1016/j.tetlet.2015.01.018
- Penas, C., Govek, E. E., Fang, Y., Ramachandran, V., Daniel, M., Wang, W., Maloof, M. E., Rahaim, R. J., Bibian, M., Kawauchi, D., Finkelstein, D., Han, J. L., et al. Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis Cell Reports 2015 11:249-260 DOI:10.1016/j.celrep.2015.03.016 PMID:25843713 PMCID:PMC4401652
- Ghalei, H., Schaub, F. X., Doherty, J. R., Noguchi, Y., Roush, W. R., Cleveland, J. L., Stroupe, M. E., Karbstein, K. Hrr25/CK1 delta-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth Journal of Cell Biology 2015 208:745-759 DOI:10.1083/jcb.201409056 PMID:25778921 PMCID:PMC4362465
- Wang, Y., Stowe, R. L., Pinello, C. E., Tian, G., Madoux, F., Li, D., Zhao, L. Y., Li, J. L., Wang, Y., Wang, Y., Ma, H., Hodder, P., et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases Chemistry & Biology 2015 22:273-284 DOI:10.1016/j.chembiol.2014.12.015 PMID:25699604 PMCID:PMC4365786
- Corzo, C. A., Mari, Y., Chang, M. R., Khan, T., Kuruvilla, D., Nuhant, P., Kumar, N., West, G. M., Duckett, D. R., Roush, W. R., Griffin, P. R. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1 Molecular Pharmacology 2015 87:296-304 DOI:10.1124/mol.114.095554 PMID:25473120 PMCID:PMC4293447
- Penas, C., Mishra, J. K., Wood, S. D., Schurer, S. C., Roush, W. R., Ayad, N. G. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation Cell Cycle 2015 14:417-424 DOI:10.4161/15384101.2014.974439 PMID:25616418 PMCID:PMC4353296
- Abbott, J. R., Allais, C., Roush, W. R. Preparattion of crystalline (diisopinocampheyl)borane Organic Syntheses 2015 92:26-37 DOI:10.15227/orgsyn.092.0026
- Abbott, J. R., Allais, C., Roush, W. R. Enantioselective reductive syn-aldol reactions of 4-acryloylmorpholine: preparation of (2R, 3S)-3-hydroxy-2-methyl-1-morpholino-5-phenylpentan-1-one Organic Syntheses 2015 92:38-57 DOI:10.15227/orgsyn.092.0038
- McCall, L. I., El Aroussi, A., Choi, J. Y., Vieira, D. F., De Muylder, G., Johnston, J. B., Chen, S., Kellar, D., Siqueira-Neto, J. L., Roush, W. R., Podust, L. M., McKerrow, J. H. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase PLoS Neglected Tropical Diseases 2015 9 DOI:10.1371/journal.pntd.0003588 PMID:25768284 PMCID:PMC4359151
- Vieira, D. F., Choi, J. Y., Calvet, C. M., Siqueira-Neto, J. L., Johnston, J. B., Kellar, D., Gut, J., Cameron, M. D., McKerrow, J. H., Roush, W. R., Podust, L. M. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51 Journal of Medicinal Chemistry 2014 57:10162-10175 DOI:10.1021/jm501568b PMID:25393646 PMCID:PMC4266343
- Choi, J. Y., Podust, L. M., Roush, W. R. Drug strategies targeting CYP51 in neglected tropical diseases Chemical Reviews 2014 114:11242-11271 DOI:10.1021/cr5003134 PMID:25337991 PMCID:PMC4254036
- Wang, H., Yang, C., Doherty, J. R., Roush, W. R., Cleveland, J. L., Bannister, T. D. Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors Journal of Medicinal Chemistry 2014 57:7317-7324 DOI:10.1021/jm500640x PMID:25068893 PMCID:PMC4161152
- Calvet, C. M., Vieira, D. F., Choi, J. Y., Kellar, D., Cameron, M. D., Siqueira-Neto, J. L., Gut, J., Johnston, J. B., Lin, L., Khan, S., McKerrow, J. H., Roush, W. R., et al. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency Journal of Medicinal Chemistry 2014 57:6989-7005 DOI:10.1021/jm500448u PMID:25101801 PMCID:PMC4148169
- Penas, C., Ramachandran, V., Simanski, S., Lee, C., Madoux, F., Rahaim, R. J., Chauhan, R., Barnaby, O., Schurer, S., Hodder, P., Steen, J., Roush, W. R., et al. Casein kinase 1 delta-dependent Wee1 protein degradation Journal of Biological Chemistry 2014 289:18893-18903 DOI:10.1074/jbc.M114.547661 PMID:24817118 PMCID:PMC4081930
- Vieira, D. F., Choi, J. Y., Roush, W. R., Podust, L. M. Expanding the binding envelope of CYP51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives ChemBioChem 2014 15:1111-1120 DOI:10.1002/cbic.201402027 PMID:24771705 PMCID:PMC4091728
- Choi, J. Y., Calvet, C. M., Vieira, D. F., Gunatilleke, S. S., Cameron, M. D., McKerrow, J. H., Podust, L. M., Roush, W. R. R-configuration of 4-aminopyridyl-based inhibitors of CYP51 confers superior efficacy against Trypanosoma cruzi ACS Medicinal Chemistry Letters 2014 5:434-439 DOI:10.1021/ml500010m PMID:24900854 PMCID:PMC4027616
- Doherty, J. R., Yang, C., Scott, K. E. N., Cameron, M. D., Fallahi, M., Li, W., Hall, M. A., Amelio, A. L., Mishra, J. K., Li, F., Tortosa, M., Genau, H. M., et al. Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis Cancer Research 2014 74:908-920 DOI:10.1158/0008-5472.can-13-2034 PMID:24285728 PMCID:PMC3946415
- Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., Minong, D., Spicer, T. P. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro Journal of Medicinal Chemistry 2014 57:9598-9611 DOI:10.1021/jm501284e PMID:25330343 PMCID:PMC4255739
- Allais, C., Tsai, A. S., Nuhant, P., Roush, W. R. Generation of stereochemically defined tetrasubstituted enolborinates by 1,4-hydroboration of α,β-unsaturated morpholine carboxamides with (diisopinocampheyl)borane Angewandte Chemie-International Edition 2013 52:12888-12891 DOI:10.1002/anie.201307302 PMID:24281884 PMCID:PMC3910328
- Kister, J., Ess, D. H., Roush, W. R. Enantio- and diastereoselective synthesis of syn-β-hydroxy-α-vinyl carboxylic esters via reductive aldol reactions of ethyl allenecarboxylate with 10-TMS-9-Borabicyclo[3.3.2]decane and DFT analysis of the hydroboration pathway Organic Letters 2013 15:5436-5439 DOI:10.1021/ol4025277 PMID:24138187 PMCID:PMC3849616
- Choi, J. Y., Calvet, C. M., Gunatilleke, S. S., Ruiz, C., Cameron, M. D., McKerrow, J. H., Podust, L. M., Roush, W. R. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents Journal of Medicinal Chemistry 2013 56:7651-7668 DOI:10.1021/jm401067s PMID:24079662 PMCID:PMC3864028
- Nuhant, P., Allais, C., Roush, W. R. Diisopinocampheylborane-mediated reductive aldol reactions: highly enantio- and diastereoselective synthesis of syn aldols from N-acryloylmorpholine Angewandte Chemie-International Edition 2013 52:8703-8707 DOI:10.1002/anie.201302535 PMID:23818095 PMCID:PMC3813003
- Allais, C., Nuhant, P., Roush, W. R. (Diisopinocampheyl)borane-mediated reductive aldol reactions of acrylate esters: enantioselective synthesis of anti-aldols Organic Letters 2013 15:3922-3925 DOI:10.1021/ol401679g PMID:23885946 PMCID:PMC3773495
- Bibian, M., Rahaim, R. J., Choi, J. Y., Noguchi, Y., Schurer, S., Chen, W. M., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., Feng, Y., Cameron, M. D., et al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties Bioorganic & Medicinal Chemistry Letters 2013 23:4374-4380 DOI:10.1016/j.bmcl.2013.05.075 PMID:23787102 PMCID:PMC3783656
- Chen, M., Roush, W. R. Enantioselective synthesis of (Z)- and (E)-2-methyl-1,5-anti-pentenediols via an allene hydroboration-double-allylboration reaction sequence Journal of the American Chemical Society 2013 135:9512-9517 DOI:10.1021/ja4033633 PMID:23758559 PMCID:PMC3733567
- Nuhant, P., Roush, W. R. Enantio- and diastereoselective synthesis of N-acetyl dihydrotetrafibricin methyl ester Journal of the American Chemical Society 2013 135:5340-5343 DOI:10.1021/ja401918r PMID:23530855 PMCID:PMC3679187
- Chen, M., Roush, W. R. Enantioselective synthesis of (E)-δ-silyl-anti-homoallylic alcohols via an enantiodivergent hydroboration-crotylboration reaction of a racemic allenylsilane Organic Letters 2013 15:1662-1665 DOI:10.1021/ol4004405 PMID:23534391 PMCID:PMC3663895
- Chen, M., Roush, W. R. Crotylboron-based synthesis of the polypropionate units of chaxamycins a/d, salinisporamycin, and rifamycin s Journal of Organic Chemistry 2013 78:3-8 DOI:10.1021/jo3008226 PMID:22703288 PMCID:PMC3465507
- Geist, J. G., Barth, R., Roush, W. R. Enantioselective synthesis of the C1-C11 fragment of tedanolide C Organic Letters 2013 15:58-61 DOI:10.1021/ol303089w PMID:23249423 PMCID:PMC3539184
- Abbott, J. R., Roush, W. R. Stereoselective synthesis of the disaccharide unit of incednine Organic Letters 2013 15:62-64 DOI:10.1021/ol303093z PMID:23249392 PMCID:PMC3537911
- Tsai, A. S., Chen, M., Roush, W. R. Chiral Brønsted acid catalyzed enantioselective synthesis of anti-homopropargyl alcohols via kinetic resolution-aldehyde allenylboration using racemic allenylboronates Organic Letters 2013 15:1568-1571 DOI:10.1021/ol4003459 PMID:23484801 PMCID:PMC3640598
- Chen, M., Roush, W. R. Enantiodivergent hydroboration reactions of a racemic allenylsilane with diisopinocampheylborane and Curtin-Hammett controlled double asymmetric crotylboration reactions of (S)-E-α-phenyldimethylsilyl(ddiisopinocampheyl)-crotylborane Tetrahedron 2013 69:5468-5475 DOI:10.1016/j.tet.2013.04.098 PMID:24039304 PMCID:PMC3768161
- Yang, H., Pinello, C. E., Luo, J., Li, D., Wang, Y., Zhao, L. Y., Jahn, S. C., Saldanha, S. A., Planck, J., Geary, K. R., Ma, H., Law, B. K., et al. Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents Molecular Cancer Therapeutics 2013 12:610-620 DOI:10.1158/1535-7163.mct-12-0930 PMID:23625935 PMCID:PMC3651759
- Dossey, A. T., Whitaker, J. M., Dancel, M. C. A., Vander Meer, R. K., Bernier, U. R., Gottardo, M., Roush, W. R. Defensive spiroketals from Asceles glaber (Phasmatodea): absolute configuration and effects on ants and mosquitoes Journal of Chemical Ecology 2012 38:1105-1115 DOI:10.1007/s10886-012-0183-x PMID:22976590 PMCID:PMC3473114
- Han, J. L., Chen, M., Roush, W. R. Diastereo- and enantioselective synthesis of (E)-2-Methyl-1,2-syn- and (E)-2-Methyl-1,2-anti-3-pentenediols via allenylboronate kinetic resolution with ((d)Ipc)2BH and aldehyde allylboration Organic Letters 2012 14:3028-3031 DOI:10.1021/ol3010968 PMID:22646839 PMCID:PMC3426628
- Chen, M., Roush, W. R. Enantioselective synthesis of (+)-crocacin C. An example of a highly challenging mismatched double asymmetric δ-stannylcrotylboration reaction Organic Letters 2012 14:1880-1883 DOI:10.1021/ol300476f PMID:22409510 PMCID:PMC3321065
- Chen, M., Roush, W. R. Enantioselective synthesis of (-)-basiliskamide A Organic Letters 2012 14:1556-1559 DOI:10.1021/ol300282e PMID:22372693 PMCID:PMC3306514
- Chen, M., Roush, W. R. Highly stereoselective synthesis of anti,anti-dipropionate stereotriads: a solution to the long-standing problem of challenging mismatched double asymmetric crotylboration reactions Journal of the American Chemical Society 2012 134:3925-3931 DOI:10.1021/ja300472a PMID:22332989 PMCID:PMC3292054
- Choi, J. Y., Plummer, M. S., Starr, J., Desbonnet, C. R., Soutter, H., Chang, J., Miller, J. R., Dillman, K., Miller, A. A., Roush, W. R. Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation Journal of Medicinal Chemistry 2012 55:852-870 DOI:10.1021/jm201349f PMID:22243413 PMCID:PMC3306445
- Chen, M., Roush, W. R. Total synthesis of (-)-tirandamycin C Organic Letters 2012 14:426-428 DOI:10.1021/ol203161u PMID:22148850 PMCID:PMC3253220
- Chen, M., Roush, W. R. Enantioselective synthesis of anti- and syn-homopropargyl alcohols via chiral Brønsted acid catalyzed asymmetric allenylboration reactions Journal of the American Chemical Society 2012 134:10947-10952 DOI:10.1021/ja3031467 PMID:22731887 PMCID:PMC3474359
- Ying, M. B., Roush, W. R. Studies on the synthesis of reidispongiolide A: stereoselective synthesis of the C(22)-C(36) fragment Tetrahedron 2011 67:10274-10280 DOI:10.1016/j.tet2011.10.029 PMID:22711935 PMCID:PMC3375686
- Roth, J., Minond, D., Darout, E., Liu, Q., Lauer, J., Hodder, P., Fields, G. B., Roush, W. R. Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds Bioorganic & Medicinal Chemistry Letters 2011 21:7180-7184 DOI:10.1016/j.bmcl.2011.09.077 PMID:22018790 PMCID:PMC3210410
- Zhou, Y. C., Agudelo, J., Lu, K., Goetz, D. H., Hansell, E., Chen, Y. T., Roush, W. R., McKerrow, J., Craik, C. S., Amberg, S. M., Simmons, G. Inhibitors of SARS-CoV entry: identification using an internally-controlled dual envelope pseudovirion assay Antiviral Research 2011 92:187-194 DOI:10.1016/j.antiviral.2011.07.016 PMID:21820471 PMCID:PMC3205982
- Nuhant, P., Kister, J., Lira, R., Sorg, A., Roush, W. R. Development of a double allylboration reagent targeting 1,5-syn-(E)-diols: application to the synthesis of the C(23)-C(40) fragment of tetrafibricin Tetrahedron 2011 67:6497-6512 DOI:10.1016/j.tet.2011.06.008 PMID:21857752 PMCID:PMC3156408
- Busby, S. A., Kumar, N., Kuruvilla, D. S., Istrate, M. A., Conkright, J. J., Wang, Y. J., Kamenecka, T. M., Cameron, M. D., Roush, W. R., Burris, T. P., Griffin, P. R. Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors ACS Chemical Biology 2011 6:618-627 DOI:10.1021/cb100396s PMID:21381756 PMCID:PMC3117942
- Sun, H. K., Abbott, J. R., Roush, W. R. Stereoselective synthesis of a model C(18)-C(35) spiroketal fragment of integramycin Organic Letters 2011 13:2734-2737 DOI:10.1021/ol200834p PMID:21510632 PMCID:PMC3094501
- Lee, Y., Choi, J. Y., Fu, H., Harvey, C., Ravindran, S., Roush, W. R., Boothroyd, J. C., Khosla, C. Chemistry and biology of macrolide antiparasitic agents Journal of Medicinal Chemistry 2011 54:2792-2804 DOI:10.1021/jm101593u PMID:21428405 PMCID:PMC3085955
- Solt, L. A., Kumar, N., Nuhant, P., Wang, Y. J., Lauer, J. L., Liu, J., Istrate, M. A., Kamenecka, T. M., Roush, W. R., Vidovic, D., Schurer, S. C., Xu, J. H., et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand Nature 2011 472:491-494 DOI:10.1038/nature10075 PMID:21499262 PMCID:PMC3148894
- Halvorsen, G. T., Roush, W. R. Stereoselective synthesis of the decahydrofluorene core of the hirsutellones Tetrahedron Letters 2011 52:2072-2075 DOI:10.1016/j.tetlet.2010.10.111 PMID:21503271 PMCID:PMC3077760
- Chen, M., Roush, W. R. Enantioconvergent hydroboration of a racemic allene: enantioselective synthesis of (E)-δ-stannyl-anti-homoallylic alcohols via aldehyde crotylboration Journal of the American Chemical Society 2011 133:5744-5747 DOI:10.1021/ja2010187 PMID:21449594 PMCID:PMC3086366
- Chen, M., Roush, W. R. Enantioselective syntheses of syn- and anti-beta-hydroxyallyisilanes via allene hydroboration-aldehyde allylboration reactions Organic Letters 2011 13:1992-1995 DOI:10.1021/ol200392u PMID:21410173 PMCID:PMC3075570
- Kister, J., Nuhant, P., Lira, R., Sorg, A., Roush, W. R. Enantio- and diastereoselective synthesis of (E)-1,5-syn-diols: application to the synthesis of the C(23)-C(40) fragment of tetrafibricin Organic Letters 2011 13:1868-1871 DOI:10.1021/ol2003836 PMID:21375316 PMCID:PMC3064748
- Stewart, P. S., Chen, M., Roush, W. R., Ess, D. H. Thermodynamic control of 1,3-boratropic shifts of α- and γ-stannyl-substituted allylboranes: hyperconjugation outweighs steric effects Organic Letters 2011 13:1478-1481 DOI:10.1021/ol2001599 PMID:21323387 PMCID:PMC3462665
- Kumar, N., Kojetin, D. J., Solt, L. A., Kumar, K. G., Nuhant, P., Duckett, D. R., Cameron, M. D., Butler, A. A., Roush, W. R., Griffin, P. R., Burris, T. P. Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist ACS Chemical Biology 2011 6:218-222 DOI:10.1021/cb1002762 PMID:21090593 PMCID:PMC3076127
- Sun, H., Roush, W. R. Synthesis of (+)-B-allyldiisopinocampheylborane and its reaction with aldehydes Organic Syntheses 2011 88:87-101 DOI:10.1002/0471264229.os088.09 PMID:22962503
- Sun, H., Roush, W. R. Synthesis of (S,S)-diisopropyl tartrate (E)-crotylboronate and its reaction with aldehydes: (2R,3R,4R)-1,2-dideoxy-2-ethenyl-4,5-O-(1-methylethylidene)xylitol Organic Syntheses 2011 88:181-196 DOI:10.1002/0471264229.os088.17 PMID:21666877
- Wang, Y. J., Kumar, N., Nuhant, P., Cameron, M. D., Istrate, M. A., Roush, W. R., Griffin, P. R., Burris, T. P. Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ ACS Chemical Biology 2010 5:1029-1034 DOI:10.1021/cb100223d PMID:20735016 PMCID:PMC3003750
- Gianni, D., Taulet, N., Zhang, H., DerMardirossian, C., Kister, J., Martinez, L., Roush, W. R., Brown, S. J., Bokoch, G. M., Rosen, H. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells ACS Chemical Biology 2010 5:981-993 DOI:10.1021/cb100219n PMID:20715845 PMCID:PMC2955773
- Winbush, S. M., Roush, W. R. Enantioselective synthesis of (Z)-1,2-anti-2,5-anti-triol monosilyl ethers using a cross-metathesis allylboration sequence Organic Letters 2010 12:4344-4347 DOI:10.1021/ol101789g PMID:20806914 PMCID:PMC2945398
- Madoux, F., Simanski, S., Chase, P., Mishra, J. K., Roush, W. R., Ayad, N. G., Hodder, P. An ultra-high throughput cell-based screen for wee1 degradation inhibitors Journal of Biomolecular Screening 2010 15:907-917 DOI:10.1177/1087057110375848 PMID:20660794 PMCID:PMC3082437
- Chen, Y. T., Brinen, L. S., Kerr, I. D., Hansell, E., Doyle, P. S., McKerrow, J. H., Roush, W. R. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi PLoS Neglected Tropical Diseases 2010 4:e825 DOI:10.1371/journal.pntd.0000825 PMID:20856868 PMCID:PMC2939063
- Chen, M., Roush, W. R. Highly (E)-selective BF(3).Et(2)O-promoted allylboration of chiral nonracemic alpha-substituted allylboronates and analysis of the origin of stereocontrol Organic Letters 2010 12:2706-2709 DOI:10.1021/ol1007444 PMID:20476769 PMCID:PMC2891445
- Chen, M., Ess, D. H., Roush, W. R. Enantioselective synthesis of (E)-delta-stannyl homoallylic alcohols via aldehyde allylboration using alpha-stannylallylboranes generated by allene hydroboration followed by a highly diastereoselective 1,3-boratropic shift Journal of the American Chemical Society 2010 132:7881-7883 DOI:10.1021/ja103041u PMID:20496899 PMCID:PMC2890212
- He, C., Nora, G. P., Schneider, E. L., Kerr, I. D., Hansell, E., Hirata, K., Gonzalez, D., Sajid, M., Boyd, S. E., Hruz, P., Cobo, E. R., Le, C., et al. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target Journal of Biological Chemistry 2010 285:18516-18527 DOI:10.1074/jbc.M109.086181 PMID:20378535 PMCID:PMC2881777
- Barth, R., Roush, W. R. Enantioselective synthesis of alpha-methylene-beta-hydroxy carboxylic acid derivatives via a diastereoselective aldol/beta-elimination sequence: application to the C(15)-C(21) fragment of tedanolide C Organic Letters 2010 12:2342-2345 DOI:10.1021/ol1006955 PMID:20405855 PMCID:PMC2872132
- Ess, D. H., Kister, J., Chen, M., Roush, W. R. Origin of thermodynamic versus kinetic control of allene hydroboration with 9-borabicyclo[3.3.1]nonane and 10(R)-trimethylsilyl-9-borabicyclo[3.3.2]decane Organic Letters 2009 11:5538-5541 DOI:10.1021/ol902364d PMID:19899749 PMCID:PMC2803353
- Ess, D. H., Kister, J., Chen, M., Roush, W. R. Quantum-mechanical study of 10-R-9-borabicyclo[3.3.2]decane alkene hydroboration Journal of Organic Chemistry 2009 74:8626-8637 DOI:10.1021/jo901737d PMID:19824624 PMCID:PMC2803351
- Chen, M., Handa, M., Roush, W. R. Enantioselective synthesis of 2-methyl-1,2-syn- and 2-methyl-1,2-anti-3-butenediols via allene hydroboration-aldehyde allylboration reaction sequences Journal of the American Chemical Society 2009 131:14602-14603 DOI:10.1021/ja904599h PMID:19778012 PMCID:PMC2762002
- Kister, J., DeBaillie, A. C., Lira, R., Roush, W. R. Stereoselective synthesis of gamma-substituted (Z)-allylic boranes via kinetically controlled hydroboration of allenes with 10-TMS-9-borabicyclo[3.3.2]decane Journal of the American Chemical Society 2009 131:14174-14175 DOI:10.1021/ja905494c PMID:19775159 PMCID:PMC2767336
- Dossey, A. T., Gottardo, M., Whitaker, J. M., Roush, W. R., Edison, A. S. Alkyldimethylpyrazines in the defensive spray of Phyllium westwoodii: a first for order Phasmatodea Journal of Chemical Ecology 2009 35:861-870 DOI:10.1007/s10886-009-9666-9 PMID:19685263 PMCID:PMC3787517
- Li, F. Z., Roush, W. R. Stereloselective synthesis of syn,syn- and syn,anti-1,3,5-triols via intramolecular hydrosilylation of substituted pent-3-en-1,5-diols Organic Letters 2009 11:2932-2935 DOI:10.1021/ol9009877 PMID:19507846 PMCID:PMC2755244
- Tortosa, M., Yakelis, N. A., Roush, W. R. Total synthesis of (+)-superstolide A Journal of Organic Chemistry 2008 73:9657-9667 DOI:10.1021/jo801794s PMID:18956845 PMCID:PMC2736345
- Dunetz, J. R., Julian, L. D., Newcom, J. S., Roush, W. R. Total syntheses of (+)-tedanolide and (+)-13-deoxytedanolide Journal of the American Chemical Society 2008 130:16407-16416 DOI:10.1021/ja8063205 PMID:18980317 PMCID:PMC2645944
- Halvorsen, G. T., Roush, W. R. Siloxacyclopentenes as dienophile-linked directing groups in intramolecular Diels-Alder reactions Organic Letters 2008 10:5313-5316 DOI:10.1021/ol802266s PMID:18954061 PMCID:PMC2650085
- Chen, Y. T., Lira, R., Hansell, E., McKerrow, J. H., Roush, W. R. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors Bioorganic & Medicinal Chemistry Letters 2008 18:5860-5863 DOI:10.1016/j.bmcl.2008.06.012 PMID:18585034 PMCID:PMC2642929
- Bates, R. H., Chen, M., Roush, W. R. Applications of chiral allylmetallating agents toward the synthesis of oxygen heterocycles Current Opinion in Drug Discovery & Development 2008 11:778-792 PMID:18946843
- Pragani, R., Roush, W. R. Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone Organic Letters 2008 10:4613-4616 DOI:10.1021/ol8018727 PMID:18808128 PMCID:PMC2626543
- Bates, R. H., Shotwell, J. B., Roush, W. R. Stereoselective syntheses of the C(1)-C(9) fragment of amphidinolide C Organic Letters 2008 10:4343-4346 DOI:10.1021/ol801852j PMID:18783230 PMCID:PMC2650083
- Huh, C. W., Roush, W. R. Highly stereoselective and modular syntheses of 10-hydroxytrilobacin and three diastereomers via stereodivergent [3 + 2]-annulation reactions Organic Letters 2008 10:3371-3374 DOI:10.1021/ol801242d PMID:18588305
- Roush, W. R. Total synthesis of biologically active natural products Journal of the American Chemical Society 2008 130:6654-6656 DOI:10.1021/ja8028813 PMID:18491856
- Dunetz, J. R., Roush, W. R. Concerning the synthesis of the tedanolide C(13)-C(23) fragment via anti-aldol reaction Organic Letters 2008 10:2059-2062 DOI:10.1021/ol800546g PMID:18422319
- Roth, J., Madoux, F., Hodder, P., Roush, W. R. Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds Bioorganic & Medicinal Chemistry Letters 2008 18:2628-2632 DOI:10.1016/j.bmcl.2008.03.027 PMID:18374567 PMCID:PMC2592603
- Winbush, S. M., Mergott, D. J., Roush, W. R. Total synthesis of (-)-spinosyn A: examination of structural features that govern the stereoselectivity of the key transannular Diels-Alder reaction Journal of Organic Chemistry 2008 73:1818-1829 DOI:10.1021/jo7024515 PMID:18215065
- Tortosa, M., Yakelis, N. A., Roush, W. R. Total synthesis of (+)-superstolide A Journal of the American Chemical Society 2008 130:2722-2723 DOI:10.1021/ja710238h PMID:18254629
- Hicks, J. D., Roush, W. R. Synthesis of the C(26)-C(42) and C(43)-C(67) pyran-containing fragments of amphidinol 3 via a common pyran intermediate Organic Letters 2008 10:681-684 DOI:10.1021/ol703042q PMID:18205377
- Handa, M., Scheidt, K. A., Bossart, M., Zheng, N., Roush, W. R. Studies on the synthesis of apoptolidin A. 1. Synthesis of the C(1)-C(11) fragment Journal of Organic Chemistry 2008 73:1031-1035 DOI:10.1021/jo702250z PMID:18163645
- Handa, M., Smith, W. J., Roush, W. R. Studies on the synthesis of apoptolidin A. 2. Synthesis of the disaccharide unit Journal of Organic Chemistry 2008 73:1036-1039 DOI:10.1021/jo7022526 PMID:18163646
- Hicks, J. D., Huh, C. W., Legg, A. D., Roush, W. R. Concerning the selective protection of (Z)-1,5-syn-ene-diols and (E)-1,5-anti-ene-diols as allylic triethylsilyl ethers Organic Letters 2007 9:5621-5624 DOI:10.1021/ol702588h PMID:18027963 PMCID:PMC2504016
- Lira, R., Roush, W. R. Enantio- and diastereoselective synthesis of syn-beta-hydroxyallylsilanes via a chiral (Z)-gamma-silylallylboronate Organic Letters 2007 9:4315-4318 DOI:10.1021/ol7018746 PMID:17867698
- Goetz, D. H., Choe, Y., Hansell, E., Chen, Y. T., McDowell, M., Jonsson, C. B., Roush, W. R., McKerrow, J., Craik, C. S. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus Biochemistry 2007 46:8744-8752 DOI:10.1021/bi0621415 PMID:17605471
- Melendez-Lopez, S. G., Herdman, S., Hirata, K., Choi, M. H., Choe, Y., Craik, C., Caffrey, C. R., Hansell, E., Chavez-Munguia, B., Chen, Y. T., Roush, W. R., McKerrow, J., et al. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model Eukaryotic Cell 2007 6:1130-1136 DOI:10.1128/ec.00094-07 PMID:17513563 PMCID:PMC1951106
- Va, P., Roush, W. R. Total synthesis of amphidinolide E and amphidinolide E stereoisomers Tetrahedron 2007 63:5768-5796 DOI:10.1016/j.tet.2007.02.058 PMID:18575572 PMCID:PMC2031846
- Halvorsen, G. T., Roush, W. R. Intramolecular Diels-Alder reactions of siloxacyclopentene constrained trienes Organic Letters 2007 9:2243-2246 DOI:10.1021/ol070858u PMID:17480094 PMCID:PMC2504012
- Lira, R., Roush, W. R. Stereoselective synthesis of the C(1)-C(19) fragment of tetrafibricin Organic Letters 2007 9:533-536 DOI:10.1021/ol0629869 PMID:17249805 PMCID:PMC2701644
- Va, P., Roush, W. R. Synthesis of 2-epi-amphidinolide E: an unexpected and highly selective C(2)inversion during an esterification reaction Organic Letters 2007 9:307-310 DOI:10.1021/ol0628098 PMID:17217291 PMCID:PMC2593877
- Va, P., Roush, W. R. Total synthesis of amphidinolide E Journal of the American Chemical Society 2006 128:15960-15961 DOI:10.1021/ja066663j PMID:17165709 PMCID:PMC2538580
- Trullinger, T. K., Qi, J., Roush, W. R. Studies on the synthesis of quartromicins A(3) and D(3): synthesis of the vertical and horizontal bis-spirotetronate fragments Journal of Organic Chemistry 2006 71:6915-6922 DOI:10.1021/jo061059c PMID:16930045 PMCID:PMC2593838
- Qi, J., Roush, W. R. Synthesis of precursors of the agalacto (exo) fragment of the quartromicins via an auxiliary-controlled exo-selective Diels-Alder reaction Organic Letters 2006 8:2795-2798 DOI:10.1021/ol0609208 PMID:16774259 PMCID:PMC2515626
- Thalji, R. K., Roush, W. R. Remarkable phosphine-effect on the intramolecular aldol reactions of unsaturated 1,5-diketones: highly regioselective synthesis of cross-conjugated dienones Journal of the American Chemical Society 2005 127:16778-16779 DOI:10.1021/ja0540851 PMID:16316211 PMCID:PMC2515627
- Lambert, W. T., Roush, W. R. Synthesis of the A-B subunit of angelmicin B Organic Letters 2005 7:5501-5504 DOI:10.1021/ol052321r PMID:16288541
- Hicks, J. D., Flamme, E. M., Roush, W. R. Synthesis of the C(43)-C(67) fragment of amphidinol 3 Organic Letters 2005 7:5509-5512 DOI:10.1021/ol052322j PMID:16288543
- Mertz, E., Tinsley, J. M., Roush, W. R. [3 + 2]-annulation reactions of chiral allylsilanes and chiral aldehydes. Studies on the synthesis of bis-tetrahydrofuran substructures of annonaceous acetogenins Journal of Organic Chemistry 2005 70:8035-8046 DOI:10.1021/jo0511290 PMID:16277325
- Tinsley, J. M., Mertz, E., Chong, P. Y., Rarig, R. A. F., Roush, W. R. Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane Organic Letters 2005 7:4245-4248 DOI:10.1021/ol051719k PMID:16146398 PMCID:PMC2507730
- Owen, R. M., Roush, W. R. Stereoselective synthesis of the C(1)-C(11) fragment of peloruside A Organic Letters 2005 7:3941-3944 DOI:10.1021/ol0514303 PMID:16119937
- Flamme, E. M., Roush, W. R. Synthesis of 2,6-trans-disubstituted 5,6-dihydropyrans from (Z)-1,5-syn-endiols Beilstein Journal of Organic Chemistry 2005 1:7 DOI:10.1186/1860-5397-1-7 PMID:16542020 PMCID:PMC1399455
- Tinsley, J. M., Roush, W. R. Total synthesis of asimicin via highly stereoselective [3 + 2] annulation reactions of substituted allylsilanes Journal of the American Chemical Society 2005 127:10818-10819 DOI:10.1021/ja051986l PMID:16076173
- Heitzman, C. L., Lambert, W. T., Mertz, E., Shotwell, J. B., Tinsley, J. M., Va, P., Roush, W. R. Efficient protiodesilylation of unactivated C(sp3)-SiMe2Ph bonds using tetrabutylammonium fluoride Organic Letters 2005 7:2405-2408 DOI:10.1021/ol0506821 PMID:15932209 PMCID:PMC2515625
- Julian, L. D., Newcom, J. S., Roush, W. R. Total synthesis of (+)-13-deoxytedanolide Journal of the American Chemical Society 2005 127:6186-6187 DOI:10.1021/ja050729d PMID:15853320
- Liu, C. M., Smith, W. J., Gustin, D. J., Roush, W. R. Experimental evidence for chair-like transition states in aldol reactions of methyl ketone lithium enolates: stereoselective synthesis and utilization of a deuterium-labeled enolate as a probe of reaction stereochemistry Journal of the American Chemical Society 2005 127:5770-5771 DOI:10.1021/ja050730c PMID:15839658
- Dineen, T. A., Roush, W. R. Stereoselective synthesis of the octahydronaphthalene unit of integramycin via an intramolecular Diels-Alder reaction Organic Letters 2005 7:1355-1358 DOI:10.1021/ol050191g PMID:15787505
- Flamme, E. M., Roush, W. R. Synthesis of the C(1)-C(25) fragment of amphidinol 3: application of the double-allylboration reaction for synthesis of 1,5-diols Organic Letters 2005 7:1411-1414 DOI:10.1021/ol050250q PMID:15787519
- Dias, L. C., Aguilar, A. M., Salles, A. G., Steil, L. J., Roush, W. R. Concerning the application of the 1H NMR ABX analysis for assignment of stereochemistry to aldols deriving from aldehydes lacking beta-branches Journal of Organic Chemistry 2005 70:10461-10465 DOI:10.1021/jo051773e PMID:16323858
- Narayan, S., Roush, W. R. Studies toward the total synthesis of angelmicin B (hibarimicin B): synthesis of a model CD-D' arylnaphthoquinone Organic Letters 2004 6:3789-3792 DOI:10.1021/ol048436x PMID:15469350
- Shotwell, J. B., Roush, W. R. Synthesis of the C11-C29 fragment of amphidinolide F Organic Letters 2004 6:3865-3868 DOI:10.1021/ol048381z PMID:15469369
- Mergott, D. J., Frank, S. A., Roush, W. R. Total synthesis of (-)-spinosyn A Proceedings of the National Academy of Sciences of the United States of America 2004 101:11955-11959 DOI:10.1073/pnas.0401247101 PMID:15173590 PMCID:PMC514415
- Durham, T. B., Blanchard, N., Savall, B. M., Powell, N. A., Roush, W. R. Total synthesis of formamicin Journal of the American Chemical Society 2004 126:9307-9317 DOI:10.1021/ja048493i PMID:15281821
- Methot, J. L., Roush, W. R. Nucleophilic phosphine organocatalysis Advanced Synthesis & Catalysis 2004 346:1035-1050 DOI:10.1002/adsc.200404087
- Roush, W. R., Neitz, R. J. Studies on the synthesis of landomycin A. Synthesis of the originally assigned structure of the aglycone, landomycinone, and revision of structure Journal of Organic Chemistry 2004 69:4906-4912 DOI:10.1021/jo049426c PMID:15255715
- Dineen, T. A., Roush, W. R. Total synthesis of cochleamycin A Organic Letters 2004 6:2043-2046 DOI:10.1021/ol049331x PMID:15176814
- Roush, W. R. Recent studies in carbonyl allylation reactions: application to the synthesis of oxygen heterocycles Actualite Chimique 2004 21-22
- Coppola, B. P., Roush, W. R. Broadening the existing intergenerational structure of scholarly development in chemistry Peer Review 2004 6:19
- Dineen, T. A., Roush, W. R. Probing the Lewis acid-catalyzed intramolecular Diels-Alder cyclizations of allylic alkoxy-substituted (Z)-1,3-dienes Organic Letters 2003 5:4725-4728 DOI:10.1021/ol035900+ PMID:14627425
- Methot, J. L., Roush, W. R. Synthetic studies toward FR182877. Remarkable solvent effect in the vinylogous morita-baylis-hillman cyclization Organic Letters 2003 5:4223-4226 DOI:10.1021/ol0357550 PMID:14572290
- Boitano, A., Emal, C. D., Leonetti, F., Blatt, N. B., Dineen, T. A., Ellman, J. A., Roush, W. R., Opipari, A. W., Glick, G. D. Structure activity studies of a novel cytotoxic benzodiazepine Bioorganic & Medicinal Chemistry Letters 2003 13:3327-3330 DOI:10.1016/s0960-894x(03)00683-8 PMID:12951119
- Reddick, J. J., Cheng, J. M., Roush, W. R. Relative rates of Michael reactions of 2'-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors Organic Letters 2003 5:1967-1970 DOI:10.1021/ol034555l PMID:12762698
- Durham, T. B., Roush, W. R. Stereoselective synthesis of 2-deoxy-beta-galactosides via 2-deoxy-2-bromo- and 2-deoxy-2-iodo-galactopyranosyl donors Organic Letters 2003 5:1871-1874 DOI:10.1021/ol034393t PMID:12762674
- Durham, T. B., Roush, W. R. Stereoselective synthesis of functionalized precursors of the CDEF and CDE 2,6-dideoxy-tetra- and trisaccharide units of durhamycins A and B Organic Letters 2003 5:1875-1878 DOI:10.1021/ol034395d PMID:12762675
- Yakelis, N. A., Roush, W. R. Synthesis of the C(21)-C(26) fragment of superstolide A: concerning the stereochemistry of (E)-crotylboration reactions of alaninal derivatives Journal of Organic Chemistry 2003 68:3838-3843 DOI:10.1021/jo0341012 PMID:12737561
- Heo, J. N., Holson, E. B., Roush, W. R. Common-intermediate strategy for synthesis of conduritols and inositols via beta-hydroxy cyclohexenylsilanes Organic Letters 2003 5:1697-1700 DOI:10.1021/ol034349d PMID:12735755
- Heo, J. N., Micalizio, G. C., Roush, W. R. Enantio- and diastereoselective synthesis of cyclic beta-hydroxy allylsilanes via sequential aldehyde gamma-silylallylboration and ring-closing metathesis reactions Organic Letters 2003 5:1693-1696 DOI:10.1021/ol034347t PMID:12735754
- Chemler, S. R., Roush, W. R. Stereochemistry of the allylation and crotylation reactions of alpha-methyl-beta-hydroxy aldehydes with allyl- and crotyltrifluorosilanes. Synthesis of anti, anti-dipropionate stereotriads and stereodivergent pathways for the reactions with 2,3-anti- and 2,3-syn-alpha-methyl-beta-hydroxy aldehydes Journal of Organic Chemistry 2003 68:1319-1333 DOI:10.1021/jo0267908 PMID:12585871
- Savall, B. M., Blanchard, N., Roush, W. R. Total synthesis of the formamicin aglycon, formamicinone Organic Letters 2003 5:377-379 DOI:10.1021/ol027569k PMID:12556196
- Blanchard, N., Roush, W. R. 2-deoxy-2-iodo-beta-glucopyranosyl fluorides: mild and highly stereoselective glycosyl donors for the synthesis of 2-deoxy-beta-glycosides from beta-hydroxy ketones Organic Letters 2003 5:81-84 DOI:10.1021/ol027257h PMID:12509896
- Shenai, B. R., Lee, B. J., Alvarez-Hernandez, A., Chong, P. Y., Emal, C. D., Neitz, R. J., Roush, W. R., Rosenthal, P. J. Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones Antimicrobial Agents and Chemotherapy 2003 47:154-160 DOI:10.1128/aac.47.1.154-160.2003 PMID:12499184 PMCID:PMC149004
- Roush, W. R., Newcom, J. S. Studies on the synthesis of tedanolide. 2. Stereoselective synthesis of a protected C(1)-C(12) fragment Organic Letters 2002 4:4739-4742 DOI:10.1021/ol0272343 PMID:12489975
- Chong, P. Y., Roush, W. R. Concerning the origin of the high beta-selectivity of glycosidation reactions of 2-deoxy-2-iodo-glucopyranosyl trichloroacetimidates Organic Letters 2002 4:4523-4526 DOI:10.1021/ol027066e PMID:12465928
- Roush, W. R., Chen, H., Reilly, M. L. Studies on the synthesis of kijanolide: synthesis of an advanced seco-acid intermediate Heterocycles 2002 58:259-282 DOI:10.3987/COM-02-S(M)17
- Flamme, E. M., Roush, W. R. Enantioselective synthesis of 1,5-anti- and 1,5-syn-diols using a highly diastereoselective one-pot double allylboration reaction sequence Journal of the American Chemical Society 2002 124:13644-13645 DOI:10.1021/ja028055j PMID:12431072
- Holson, E. B., Roush, W. R. Diastereoselective synthesis of the C(17)-C(28) fragment (the C-D spiroketal unit) of spongistatin 1 (altohyrtin A) via a kinetically controlled iodo-spiroketalization reaction Organic Letters 2002 4:3719-3722 DOI:10.1021/ol0266875 PMID:12375927
- Holson, E. B., Roush, W. R. Synthesis of the C(2)-C(13) fragment (the A-B spiroketal unit) of spongistatin 1 (altohyrtin A): use of a common intermediate for the synthesis of both spongistatin spiroketals Organic Letters 2002 4:3723-3725 DOI:10.1021/ol026688x PMID:12375928
- Gung, B. W., Xue, X. W., Roush, W. R. The origin of diastereofacial control in allylboration reactions using tartrate ester derived allylboronates: attractive interactions between the Lewis acid coordinated aldehyde carbonyl group and an ester carbonyl oxygen Journal of the American Chemical Society 2002 124:10692-10697 DOI:10.1021/ja026373c PMID:12207523
- Mergott, D. J., Frank, S. A., Roush, W. R. Application of the intramolecular vinylogous Morita-Baylis-Hillman reaction toward the synthesis of the spinosyn A tricyclic nucleus Organic Letters 2002 4:3157-3160 DOI:10.1021/ol026540d PMID:12201741
- Roush, W. R., Barda, D. A., Limberakis, C., Kunz, R. K. Studies on the synthesis of the quartromicins: partial stereochemical assignment of quartromicins a(3) and d-3 and diastereoselective synthesis of the endo- and exo-spirotetronate subunits Tetrahedron 2002 58:6433-6454 DOI:10.1016/s0040-4020(02)00656-7
- Hernandez, A. A., Roush, W. R. Recent advances in the synthesis, design and selection of cysteine protease inhibitors Current Opinion in Chemical Biology 2002 6:459-465 DOI:10.1016/s1367-5931(02)00345-9 PMID:12133721
- Roush, W. R., Hertel, L., Schnaderbeck, M. J., Yakelis, N. A. Synthesis of the C(18)-(C26) segment of superstolide A Tetrahedron Letters 2002 43:4885-4887 DOI:10.1016/s0040-4039(02)00903-6
- Scheidt, K. A., Bannister, T. D., Tasaka, A., Wendt, M. D., Savall, B. M., Fegley, G. J., Roush, W. R. Total synthesis of (-)-bafilomycin A(1) Journal of the American Chemical Society 2002 124:6981-6990 DOI:10.1021/ja017885e PMID:12059221
- Roush, W. R., Bannister, T. D., Wendt, M. D., VanNieuwenhze, M. S., Gustin, D. J., Dilley, G. J., Lane, G. C., Scheidt, K. A., Smith, W. J. An NMR method for assigning relative stereochemistry to beta-hydroxy ketones deriving from aldol reactions of methyl ketones Journal of Organic Chemistry 2002 67:4284-4289 DOI:10.1021/jo0164148 PMID:12054964
- Frank, S. A., Roush, W. R. Studies on the synthesis of (-)-spinosyn A: application of the steric directing group strategy to transannular Diels-Alder reactions Journal of Organic Chemistry 2002 67:4316-4324 DOI:10.1021/jo025580s PMID:12054969
- Roush, W. R., Bannister, T. D., Wendt, M. D., Jablonowski, J. A., Scheidt, K. A. Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment Journal of Organic Chemistry 2002 67:4275-4283 DOI:10.1021/jo016413f PMID:12054963
- Frank, S. A., Mergott, D. J., Roush, W. R. The vinylogous intramolecular Morita-Baylis-Hillman reaction: synthesis of functionalized cyclopentenes and cyclohexenes with trialkylphosphines as nucleophilic catalysts Journal of the American Chemical Society 2002 124:2404-2405 DOI:10.1021/ja017123j PMID:11890766
- Roush, W. R., Limberakis, C., Kunz, R. K., Barda, D. A. Diastereoselective synthesis of the endo- and exo-spirotetronate subunits of the quartromicins. The first enantioselective Diels-Alder reaction of an acyclic (Z)-1,3-diene Organic Letters 2002 4:1543-1546 DOI:10.1021/ol025772+ PMID:11975624
- Roush, W. R., Barda, D. A. Partial stereochemical assignment of quartromicins A3 and D3 Organic Letters 2002 4:1539-1542 DOI:10.1021/ol025771h PMID:11975623
- Roush, W. R., Powell, N. A., James, R. A. Synthesis of structurally simplified aureolic acid aglycone-C-D-E trisaccharide analogues Australian Journal of Chemistry 2002 55:113-121 DOI:10.1071/ch01198
- Roush, W. R., James, R. A. Towards the synthesis of aureolic acid analogue conjugates: synthesis and glycosidation reactions of 3-O-acetyl-4-azido-2,4,6-trideoxy-L-glucopyranose derivatives Australian Journal of Chemistry 2002 55:141-146 DOI:10.1071/ch01199
- Caffrey, C. R., Hansell, E., Lucas, K. D., Brinen, L. S., Hernandez, A. A., Cheng, J. N., Gwaltney, S. L., Roush, W. R., Stierhof, Y. D., Bogyo, M., Steverding, D., McKerrow, J. H. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense Molecular and Biochemical Parasitology 2001 118:61-73 DOI:10.1016/s0166-6851(01)00368-1 PMID:11704274
- Roush, W. R., Madar, D. J., Coffey, D. S. Synthesis of highly functionalized naphthoate precursors to damavaricin D: observation of kinetically stable benzocyclohexadienones in the bromination reactions of highly functionalized beta-naphthol derivatives Canadian Journal of Chemistry-Revue Canadienne De Chimie 2001 79:1711-1726 DOI:10.1139/cjc-79-11-1711
- Roush, W. R., Cheng, J. M., Knapp-Reed, B., Alvarez-Hernandez, A., McKerrow, J. H., Hansell, E., Engel, J. C. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain Bioorganic & Medicinal Chemistry Letters 2001 11:2759-2762 DOI:10.1016/s0960-894x(01)00566-2 PMID:11591518
- Roush, W. R., Bennett, C. E., Roberts, S. E. Studies on the synthesis of landomycin A: synthesis and glycosidation reactions of L-rhodinosyl acetate derivatives Journal of Organic Chemistry 2001 66:6389-6393 DOI:10.1021/jo015756a PMID:11559191
- Savall, B. M., Powell, N. A., Roush, W. R. Highly diastereoselective synthesis of propargylic 1,2-anti-diol derivatives using alpha-alkoxypropargylstannanes Organic Letters 2001 3:3057-3060 DOI:10.1021/ol016536m PMID:11554842
- Micalizio, G. C., Roush, W. R. Studies on the synthesis of pectenotoxin II: synthesis of a C(11)-C(26) fragment precursor via [3 + 2]-annulation reactions of chiral allylsilanes Organic Letters 2001 3:1949-1952 DOI:10.1021/ol0160250 PMID:11405752
- Menard, R., Therrien, C., Lachance, P., Sulea, T., Qi, H. T., Alvarez-Hernandez, A., Roush, W. R. Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design Biological Chemistry 2001 382:839-845 DOI:10.1515/bc.2001.102 PMID:11517939
- Yakelis, N. A., Roush, W. R. Lewis acid catalyzed intramolecular Diels-Alder reactions of acyclic (Z)-substituted 1,3-dienes Organic Letters 2001 3:957-960 DOI:10.1021/ol015667k PMID:11263925
- Therrien, C., Lachance, P., Sulea, T., Purisima, E. O., Qi, H. T., Ziomek, E., Alvarez-Hernandez, A., Roush, W. R., Menard, R. Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities Biochemistry 2001 40:2702-2711 DOI:10.1021/bi002460a PMID:11258881
- Powell, N. A., Roush, W. R. Studies on the total synthesis of formamicin: synthesis of the C(1)-C(11) fragment Organic Letters 2001 3:453-456 DOI:10.1021/ol0069610 PMID:11428037
- Roush, W. R., Dilley, G. J. Studies on the synthesis of 2,6-disubstituted dihydropyrans: intervention of oxonia-Cope rearrangements in the Lewis acid mediated cyclodehydrative reactions of aldehydes and beta-hydroxyallylsilanes Synlett 2001 2001:955-959 DOI:10.1055/s-2001-14632
- Micalizio, G. C., Pinchuk, A. N., Roush, W. R. Synthesis of the C(29)-C(45) bis-pyran subunit (E-F) of spongistatin 1 (Altohyrtin A) Journal of Organic Chemistry 2000 65:8730-8736 DOI:10.1021/jo001236o PMID:11112596
- Roush, W. R., Hernandez, A. A., McKerrow, J. H., Selzer, P. M., Hansell, E., Engel, J. C. Design, synthesis and evaluation of D-homophenylalanyl epoxysuccinate inhibitors of the trypanosomal cysteine protease cruzain Tetrahedron 2000 56:9747-9762 DOI:10.1016/s0040-4020(00)00882-6
- Roush, W. R., Pinchuk, A. N., Micalizio, G. C. (E)-gamma-(dimethylphenylsilyl)allyl diisopinocampheylborane: a highly enantioselective reagent for the synthesis of anti-beta-hydroxyallylsilanes Tetrahedron Letters 2000 41:9413-9417 DOI:10.1016/s0040-4039(00)01526-4
- Frank, S. A., Chen, H., Kunz, R. K., Schnaderbeck, M. J., Roush, W. R. Use of thallium(I) ethoxide in Suzuki cross coupling reactions Organic Letters 2000 2:2691-2694 DOI:10.1021/ol0062446 PMID:10990429
- Brinen, L. S., Hansell, E., Cheng, J. M., Roush, W. R., McKerrow, J. H., Fletterick, R. J. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease Structure with Folding & Design 2000 8:831-840 DOI:10.1016/s0969-2126(00)00173-8 PMID:10997902
- Roush, W. R., Bennett, C. E. A highly stereoselective synthesis of the landomycin A hexasaccharide unit Journal of the American Chemical Society 2000 122:6124-6125 DOI:10.1021/ja000743k
- Frank, S. A., Works, A. B., Roush, W. R. Studies on the synthesis of the decahydro-as-indacene ring system of (-)-spinosyn A via transannular Diels-Alder reactions of substituted (E,E,E)-cyclododeca-1,6,8-trienes Canadian Journal of Chemistry-Revue Canadienne De Chimie 2000 78:757-771 DOI:10.1139/cjc-78-6-757
- Roush, W. R., Pfeifer, L. A. Total synthesis of mycalamide A and 7-epi-mycalamide A Organic Letters 2000 2:859-862 DOI:10.1021/ol005629l PMID:10754688
- Micalizio, G. C., Roush, W. R. A three-component coupling strategy for tetrahydrofuran synthesis: application of the diisopropyl tartrate modified (E)-gamma-(dimethylphenylsilyl)allylboronate as an alpha,gamma-allyl dianion equivalent Organic Letters 2000 2:461-464 DOI:10.1021/ol9913082 PMID:10814351
- Roush, W. R., Gung, B. W., Bennett, C. E. 2-deoxy-2-iodo- and 2-deoxy-2-bromo-alpha-glucopyranosyl trichloroacetimidates: highly reactive and stereoselective donors for the synthesis of 2-deoxy-beta-glycosides Organic Letters 1999 1:891-893 DOI:10.1021/ol9908070 PMID:10823218
- Roush, W. R., Narayan, S. 2-deoxy-2-iodo-alpha-mannopyranosyl and -talopyranosyl acetates: highly stereoselective glycosyl donors for the synthesis of 2-deoxy-alpha-glycosides Organic Letters 1999 1:899-902 DOI:10.1021/ol9908068 PMID:10823220
- Roush, W. R., Narayan, S., Bennett, C. E., Briner, K. Iodoacetoxylation of glycals using cerium(IV) ammonium nitrate, sodium iodide, and acetic acid: stereoselective synthesis of 2-deoxy-2-iodo-alpha-mannopyranosyl acetates Organic Letters 1999 1:895-897 DOI:10.1021/ol990815g PMID:10823219
- Roush, W. R., Lane, G. C. Studies on the synthesis of tedanolide: synthesis of the C(5)-C(21) segment via a highly stereoselective fragment assembly aldol reaction of a chiral beta,gamma-unsaturated methyl ketone Organic Letters 1999 1:95-98 DOI:10.1021/ol990572s PMID:10822542
- Roush, W. R., Dilley, G. J. Studies of fragment assembly aldol reactions of chiral aldehydes and chiral methyl ketones: stereoselective synthesis of the C(13)-C(25) segment of scytophycin C Tetrahedron Letters 1999 40:4955-4959 DOI:10.1016/s0040-4039(99)00868-0
- Chemler, S. R., Roush, W. R. Stereochemically divergent pathways for the allylation and crotylation reactions of anti- and syn-beta-hydroxy-alpha-methyl aldehydes with allyl- and crotyltrifluorosilanes Tetrahedron Letters 1999 40:4643-4647 DOI:10.1016/s0040-4039(99)00730-3
- Micalizio, G. C., Roush, W. R. Towards the synthesis of spongistatin 1: diastereoselective synthesis of the C(36)-C(45) subunit Tetrahedron Letters 1999 40:3351-3354 DOI:10.1016/s0040-4039(99)00464-5
- Roush, W. R., Bennett, C. E. A highly stereoselective synthesis of 2-deoxy-beta-glycosides using 2-deoxy-2-iodo-glucopyranosyl acetate donors Journal of the American Chemical Society 1999 121:3541-3542 DOI:10.1021/ja984365j
- Chemler, S. R., Coffey, D. S., Roush, W. R. An improved synthesis of the (E,Z)-dienoate precursor of (+)-damavaricin D via a vinylogous Horner-Wadsworth-Emmons reaction Tetrahedron Letters 1999 40:1269-1272 DOI:10.1016/s0040-4039(98)02638-0
- Roush, W. R., Hernandez, A. A., Zepeda, G. A new synthesis of peptidyl epoxysuccinates for probing cysteine protease-inhibitor p-3/s-3 binding interactions Synthesis-Stuttgart 1999 1999:1500-1504 DOI:10.1055/s-1999-3648
- Scheidt, K. A., Tasaka, A., Bannister, T. D., Wendt, M. D., Roush, W. R. Total synthesis of (-)-bafilomycin A(1): application of diastereoselective crotylboration and methyl ketone aldol reactions Angewandte Chemie-International Edition 1999 38:1652-1655 DOI:10.1002/(sici)1521-3773(19990601)38:11<1652::aid-anie1652>3.0.co;2-k
- Roush, W. R., Hartz, R. A., Gustin, D. J. Total synthesis of olivomycin A Journal of the American Chemical Society 1999 121:1990-1991 DOI:10.1021/ja984229e
- Scheidt, K. A., Roush, W. R., McKerrow, J. H., Selzer, P. M., Hansell, E., Rosenthal, P. J. Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors Bioorganic & Medicinal Chemistry 1998 6:2477-2494 DOI:10.1016/s0968-0896(98)80022-9 PMID:9925304
- Roush, W. R., Gwaltney, S. L., Cheng, J. M., Scheidt, K. A., McKerrow, J. H., Hansell, E. Vinyl sulfonate esters and vinyl sulfonamides: potent, irreversible inhibitors of cysteine proteases Journal of the American Chemical Society 1998 120:10994-10995 DOI:10.1021/ja981792o
- Roush, W. R., Gonzalez, F. V., McKerrow, J. H., Hansell, E. Design and synthesis of dipeptidyl alpha',beta '-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain Bioorganic & Medicinal Chemistry Letters 1998 8:2809-2812 DOI:10.1016/s0960-894x(98)00494-6 PMID:9873627
- Scheidt, K. A., Chen, H., Follows, B. C., Chemler, S. R., Coffey, D. S., Roush, W. R. Tris(dimethylamino)sulfonium difluorotrimethylsilicate, a mild reagent for the removal of silicon protecting groups Journal of Organic Chemistry 1998 63:6436-6437 DOI:10.1021/jo981215i
- Roush, W. R., Sciotti, R. J. Studies on the synthesis of chlorothricolide: diastereo- and enantioselective syntheses of model top-half spirotetronate units Journal of Organic Chemistry 1998 63:5473-5482 DOI:10.1021/jo980379w
- Roush, W. R., Sciotti, R. J. Enantioselective total synthesis of (-)-chlorothricolide via the tandem inter- and intramolecular Diels-Alder reaction of a hexaenoate intermediate Journal of the American Chemical Society 1998 120:7411-7419 DOI:10.1021/ja980611f
- Chemler, S. R., Roush, W. R. Concerning the synthesis of the elusive anti,anti-dipropionate stereotriad via the crotylation of beta-hydroxy alpha-methyl aldehydes with (Z)-crotyltrifluorosilane. Application to the synthesis of the C(7)-C(16) segment of zincophorin Journal of Organic Chemistry 1998 63:3800-3801 DOI:10.1021/jo980387c
- Roush, W. R., Pfeifer, L. A. Stereoselective N-acylation reactions of alpha-alkoxy carbamates Journal of Organic Chemistry 1998 63:2062-2063 DOI:10.1021/jo980024c
- Roush, W. R., Pfeifer, L. A., Marron, T. G. Studies on the synthesis of the mycalamides: Stereocontrolled synthesis of a model N-glycosylpederamide via a stereoselective aldol reaction Journal of Organic Chemistry 1998 63:2064-2065 DOI:10.1021/jo980023k
- Roush, W. R., Barda, D. A. An intramolecular Diels-Alder approach to the spirotetronic acid subunits of the quartromicins Tetrahedron Letters 1997 38:8781-8784 DOI:10.1016/s0040-4039(97)10415-4
- Roush, W. R., Barda, D. A. Second generation synthesis of the quartromicin spirotetronic acid subunits via a Claisen rearrangement intramolecular aldol sequence Tetrahedron Letters 1997 38:8785-8788 DOI:10.1016/s0040-4039(97)10416-6
- Roush, W. R., Reilly, M. L., Koyama, K., Brown, B. B. A formal total synthesis of (+)-tetronolide, the aglycon of the tetrocarcins: enantio- and diastereoselective syntheses of the octahydronaphthalene (bottom-half) and spirotetronate (top-half) fragments Journal of Organic Chemistry 1997 62:8708-8721 DOI:10.1021/jo970960c
- Roush, W. R., Coffey, D. S., Madar, D. J. Total synthesis of (+)-damavaricin D Journal of the American Chemical Society 1997 119:11331-11332 DOI:10.1021/ja971828x
- Roush, W. R., Barda, D. A. Highly selective Lewis acid catalyzed Diels-Alder reactions of acyclic (Z)-1,3-dienes Journal of the American Chemical Society 1997 119:7402-7403 DOI:10.1021/ja971070h
- Roush, W. R., Sebesta, D. P., Bennett, C. E. Stereoselective synthesis of 2-deoxy-beta-glycosides from glycal precursors. 1. Stereochemistry of the reactions of D-glucal derivatives with phenylsulfenyl chloride and phenylselenenyl chloride Tetrahedron 1997 53:8825-8836 DOI:10.1016/s0040-4020(97)90394-x
- Roush, W. R., Sebesta, D. P., James, R. A. Stereoselective synthesis of 2-deoxy-beta-glycosides from glycal precursors. 2. Stereochemistry of glycosidation reactions of 2-thiophenyl- and 2-selenophenyl-alpha-D-gluco-pyranosyl donors Tetrahedron 1997 53:8837-8852 DOI:10.1016/s0040-4020(97)00572-3
- Hunt, J. A., Roush, W. R. 4,5-diisopropyl-B-[(E)-[(3'-menthofuryl)dimethylsilyl]allyl]-1,3,2-dioxaborolane, an improved chiral reagent for the anti alpha-hydroxyallylation of aldehydes: application to the enantioselective synthesis of (-)-swainsonine Journal of Organic Chemistry 1997 62:1112-1124 DOI:10.1021/jo961840s
- Roush, W. R., Marron, T. G., Pfeifer, L. A. Highly diastereoselective synthesis of pederic acid derivatives Journal of Organic Chemistry 1997 62:474-478 DOI:10.1021/jo961841k PMID:11671436
- Roush, W. R., Works, A. B. Diastereofacially selective enolate Claisen rearrangements of 4-7-eta 4-(1-acyloxy-2,4,6-octatrienyl) tricarbonyliron complexes Tetrahedron Letters 1997 38:351-354 DOI:10.1016/s0040-4039(96)02349-0
- Roush, W. R., Champoux, J. A., Peterson, B. C. Diastereoselective synthesis of the cis-octahydronaphthalene nucleus of superstolides A and B Tetrahedron Letters 1996 37:8989-8992 DOI:10.1016/s0040-4039(96)02110-7
- Roush, W. R., Works, A. B. Diastereoselective synthesis of the trans-anti-cis-decahydro-as-indacene ring system via the transannular Diels-Alder reaction of a functionalized (E,E,E)-cyclododeca-1,6,8-triene Tetrahedron Letters 1996 37:8065-8068 DOI:10.1016/0040-4039(96)01840-0
- Hunt, J. A., Roush, W. R. Solid-phase synthesis of 6-deoxyoligosaccharides Journal of the American Chemical Society 1996 118:9998-9999 DOI:10.1021/ja962128f
- Roush, W. R., Briner, K., Kesler, B. S., Murphy, M., Gustin, D. J. Studies on the synthesis of aureolic acid antibiotics: acyloin glycosidation studies Journal of Organic Chemistry 1996 61:6098-6099 DOI:10.1021/jo960932e PMID:11667440
- Roush, W. R., Coffey, D. S., Madar, D., Palkowitz, A. D. Studies on the synthesis of the streptovaricins: total synthesis of 24,27-dimethyl dihydrodamavaricin D Journal of the Brazilian Chemical Society 1996 7:327-334
- Roush, W. R., Koyama, K., Curtin, M. L., Moriarty, K. J. Studies on the synthesis of nargenicin A(1): highly stereoselective synthesis of the complete carbon framework via the transannular Diels-Alder reaction of an 18-membered macrolide Journal of the American Chemical Society 1996 118:7502-7512 DOI:10.1021/ja9607796
- Roush, W. R., Coffey, D. S. Synthesis of the naphthoquinone nucleus of awamycin Journal of Organic Chemistry 1995 60:4412-4418 DOI:10.1021/jo00119a018
- Gustin, D. J., Vannieuwenhze, M. S., Roush, W. R. Diastereoselective aldol reactions of chiral aldehydes and chiral methyl ketones: dependence of stereoselectivity on the metal enolate, the aldehyde 2,3-stereochemistry, and the aldehyde β-alkoxy protecting group Tetrahedron Letters 1995 36:3443-3446 DOI:10.1016/0040-4039(95)00626-n
- Gustin, D. J., Vannieuwenhze, M. S., Roush, W. R. Synthesis of the C(3)-C(15) segment of rutamycin B via a C(8)-C(9) fragment assembly aldol reaction: metal dependence of the aldehyde and enolate diastereofacial selectivities Tetrahedron Letters 1995 36:3447-3450 DOI:10.1016/0040-4039(95)00628-p
- Marron, T. G., Roush, W. R. Diastereoselective synthesis of N-benzoyl mycalamine, the fully elaborated trioxadecalin nucleus of mycalamide. A. Control of the key N-acyl aminal stereocenter via carbamate acylation Tetrahedron Letters 1995 36:1581-1584 DOI:10.1016/0040-4039(95)00093-r
- Roush, W. R., Lin, X. F. Studies on the synthesis of aureolic acid antibiotics: highly stereoselective synthesis of aryl 2-deoxy-beta-glycosides via the Mitsunobu reaction and synthesis of the olivomycin A-B disaccharide Journal of the American Chemical Society 1995 117:2236-2250 DOI:10.1021/ja00113a013
- Hunt, J. A., Roush, W. R. Diisopropyl tartrate-modified (E)-γ-[(menthofuryl)dimethylsilyl]-allyl boronate, an improved chiral reagent for the anti α-hydroxyallylation of aldehydes. Application to the enantioselective synthesis of (−)-swainsonine Tetrahedron Letters 1995 36:501-504 DOI:10.1016/0040-4039(94)02295-m
- Roush, W. R., Hunt, J. A. Asymmetric allylboration of 2-N,3-O-isopropylidene-N-boc-L-serinal: diastereoselective synthesis of the calicheamicin gamma1I amino sugar Journal of Organic Chemistry 1995 60:798-806 DOI:10.1021/jo00109a008
- Roush, W. R., Grover, P. T. N,N'-bis(2,2,2-trifluoroethyl)-N,N'-ethylenetartramide: an improved chiral auxiliary for the asymmetric allylboration reaction Journal of Organic Chemistry 1995 60:3806-3813 DOI:10.1021/jo00117a036
- Wada, C. K., Roush, W. R. Highly stereoselective 1,4-addition reactions of alkylidene malonate substituted η4-(1,3-butadienyl)iron(tricarbonyl) complexes Tetrahedron Letters 1994 35:7351-7354 DOI:10.1016/0040-4039(94)85311-8
- Roush, W. R., Wada, C. K. Highly stereoselective substitution reactions of functionalized η4-[3(E),5(E)-heptadien-2-ol]iron tricarbonyl complexes Tetrahedron Letters 1994 35:7347-7350 DOI:10.1016/0040-4039(94)85310-x
- Roush, W. R., Vannieuwenhze, M. S. [(Z)-gamma-[(Diisopropylidene-alpha-D-mannopyranosyl)oxy]allyl]tributylstannane: a new chiral reagent for the asymmetric alpha-hydroxyallylation of aldehydes Journal of the American Chemical Society 1994 116:8536-8543 DOI:10.1021/ja00098a014
- Li, Z., Chen, X., Davidson, E., Zwang, O., Mendis, C., Ring, C. S., Roush, W. R., Fegley, G., Li, R., Rosenthal, P. J., Lee, G. K., Kenyon, G. L., et al. Anti-malarial drug development using models of enzyme structure Chemistry & Biology 1994 1:31-37 DOI:10.1016/1074-5521(94)90038-8 PMID:9383368
- Roush, W. R., Sciotti, R. J. Enantioselective total synthesis of (-)-chlorothricolide Journal of the American Chemical Society 1994 116:6457-6458 DOI:10.1021/ja00093a065
- Roush, W. R., Gustin, D. A stereochemically general synthesis of methyl 2,4,6-trideoxy-4-methylthio-α-D-ribo-pyranoside, the thio sugar of esperamicin A(1) Tetrahedron Letters 1994 35:4931-4934 DOI:10.1016/s0040-4039(00)73285-0
- Roush, W. R., Follows, B. C. Asymmetric synthesis of the hydroxylamino sugar of calicheamicin Tetrahedron Letters 1994 35:4935-4938 DOI:10.1016/s0040-4039(00)73286-2
- Roush, W. R., Wada, C. K. Application of eta4-diene iron tricarbonyl complexes in acyclic stereocontrol: asymmetric synthesis of the as-indacene unit of ikarugamycin (a formal total synthesis) Journal of the American Chemical Society 1994 116:2151-2152 DOI:10.1021/ja00084a068
- Roush, W. R., Grover, P. T., Marron, T. G. Allylboronates in organic synthesis: design of an improved chiral auxiliary and synthesis of the trioxadecalin nucleus of mycalamides A and B Special publication (Royal Society of Chemistry (Great Britain)) 1994 143:113-118
- Roush, W. R., Bannister, T. D., Wendt, M. D. Concerning the diastereofacial selectivity of aldol reactions of chiral methyl ketone enolates: evidence for remote chelation in the bafilomycin aldol reaction Tetrahedron Letters 1993 34:8387-8390 DOI:10.1016/s0040-4039(00)61340-0
- Roush, W. R., Lin, X. F. Synthesis of naphthyl A–B disaccharides corresponding to olivomycin A and mithramycin Tetrahedron Letters 1993 34:6829-6832 DOI:10.1016/s0040-4039(00)91806-9
- Roush, W. R., Warmus, J. S., Works, A. B. Synthesis and transannular diels-alder reactions of (E,E,E)-cyclotetradeca-2,8,10-trienones Tetrahedron Letters 1993 34:4427-4430 DOI:10.1016/0040-4039(93)88050-s
- Roush, W. R., Brown, B. B. A highly diastereoselective and enantioselective synthesis of the top half of kijanolide Journal of Organic Chemistry 1993 58:2151-2161 DOI:10.1021/jo00060a035
- Roush, W. R., Brown, B. B. Studies on the synthesis of kijanolide: synthesis of the 2-acyl spiro tetronate and investigations concerning the coupling of the top and bottom half fragments Journal of Organic Chemistry 1993 58:2162-2172 DOI:10.1021/jo00060a036
- Roush, W. R., Briner, K., Sebesta, D. P. Highly stereoselective synthesis of alpha-L-olivomycosides via trimethylsilyl triflate mediated glycosidations of 1-O-acetyl-4-O-isobutyryl-2,6-dideoxy-2-iodo-3-C-methyl-alpha-L-mannopyranose Synlett 1993 1993:264-266 DOI:10.1055/s-1993-22425
- Roush, W. R., Brown, B. B. Application of the steric directing group strategy to the stereoselective synthesis of the octahydronaphthalene substructure of kijanolide and tetronolide Journal of the American Chemical Society 1993 115:2268-2278 DOI:10.1021/ja00059a024
- Roush, W. R., Madar, D. J. Towards the synthesis of streptovaricin D: synthesis of fully elaborated aromatic precursors and coupling with ansa chain fragments Tetrahedron Letters 1993 34:1553-1556 DOI:10.1016/0040-4039(93)85004-g
- Roush, W. R., Marron, T. G. Toward the synthesis of mycalamides A, B and onnamide A: a highly stereoselective synthesis of the trioxadecalin ring system Tetrahedron Letters 1993 34:5421-5424 DOI:10.1016/s0040-4039(00)73924-4
- Roush, W. R., Murphy, M. An improved synthesis of naphthoate precursors to olivin Journal of Organic Chemistry 1992 57:6622-6629 DOI:10.1021/jo00050a047
- Roush, W. R., Koyama, K. Enantioselective synthesis of the top half of tetronolide Tetrahedron Letters 1992 33:6227-6230 DOI:10.1016/s0040-4039(00)60939-5
- Sebesta, D. P., Roush, W. R. Synthesis of C-D-E trisaccharide precursors of olivomycin A Journal of Organic Chemistry 1992 57:4799-4802 DOI:10.1021/jo00044a010
- Roush, W. R., Sciotti, R. J. Enantioselective synthesis of the top half of chlorothricolide Tetrahedron Letters 1992 33:4691-4694 DOI:10.1016/s0040-4039(00)61260-1
- Roush, W. R., Bannister, T. D. Stereoselective synthesis of the C(13)-C(25) segment of bafilomycin A(1) Tetrahedron Letters 1992 33:3587-3590 DOI:10.1016/s0040-4039(00)92509-7
- Roush, W. R., Brown, B. B. Enantioselective synthesis of 2-alkyl-5-methylene-1,3-dioxolan-4-ones and exo-selective Diels-Alder reactions with cyclopentadiene Journal of Organic Chemistry 1992 57:3380-3387 DOI:10.1021/jo00038a028
- Roush, W. R., Ratz, A. M., Jablonowski, J. A. Solid-state and solution conformational-analysis of tartrate-derived 1,3-dioxolanes and 1,3,2-dioxaborolanes Journal of Organic Chemistry 1992 57:2047-2052 DOI:10.1021/jo00033a027
- Roush, W. R., Grover, P. T. Diisopropyl tartrate modified (E)-γ-[(cyclohexyloxy)dimethylsilyl]- and (E)-γ-(dimethylphenylsilyl)allylboronates: chiral reagents for the enantio- and diastereoselective synthesis of anti 1,2-diols and 2-butene-1,4-diols via the formal α- and γ-hydroxyallylation of aldehydes Tetrahedron 1992 48:1981-1998 DOI:10.1016/s0040-4020(01)88869-4
- Roush, W. R., Park, J. C. Asymmetric allylborations of 3-decynal dicobalt hexacarbonyl: cobalt induced reversal of enantioselectivity and applications to highly diastereoselective intramolecular Pauson-Khand reactions Tetrahedron Letters 1991 32:6285-6288 DOI:10.1016/0040-4039(91)80148-y
- Roush, W. R., Lin, X. F. A highly stereoselective synthesis of aryl 2-deoxy-beta-glycosides via the Mitsunobu reaction Journal of Organic Chemistry 1991 56:5740-5742 DOI:10.1021/jo00020a003
- Roush, W. R. Concerning the diastereofacial selectivity of the aldol reactions of alpha-methyl chiral aldehydes and lithium and boron propionate enolates Journal of Organic Chemistry 1991 56:4151-4157 DOI:10.1021/jo00013a015
- Roush, W. R., Lin, X. F., Straub, J. A. A highly stereoselective synthesis of the AB disaccharide unit of olivomycin A Journal of Organic Chemistry 1991 56:1649-1655 DOI:10.1021/jo00004a054
- Roush, W. R., Straub, J. A., Vannieuwenhze, M. S. A stereochemically general synthesis of 2-deoxyhexoses via the asymmetric allylboration of 2,3-epoxyaldehydes Journal of Organic Chemistry 1991 56:1636-1648 DOI:10.1021/jo00004a053
- Roush, W. R., Kageyama, M., Riva, R., Brown, B. B., Warmus, J. S., Moriarty, K. J. Enantioselective synthesis of the bottom half of chlorothricolide. 3. Studies of the steric directing group strategy for stereocontrol in intramolecular Diels-Alder reactions Journal of Organic Chemistry 1991 56:1192-1210 DOI:10.1021/jo00003a049
- Roush, W. R., Palkowitz, A. D., Ando, K. Acyclic diastereoselective synthesis using tartrate ester modified crotylboronates: double asymmetric reactions with alpha-methyl chiral aldehydes and synthesis of the C19-C29 segment of rifamycin S Journal of the American Chemical Society 1990 112:6348-6359 DOI:10.1021/ja00173a024
- Roush, W. R., Ando, K., Powers, D. B., Palkowitz, A. D., Halterman, R. L. Asymmetric-synthesis using diisopropyl tartrate modified (E)-crotylboronates and (Z)-crotylboronates: preparation of the chiral crotylboronates and reactions with achiral aldehydes Journal of the American Chemical Society 1990 112:6339-6348 DOI:10.1021/ja00173a023
- Roush, W. R., Hoong, L. K., Palmer, M. A. J., Straub, J. A., Palkowitz, A. D. Asymmetric synthesis using tartrate ester modified allylboronates. 2. Single and double asymmetric reactions with alkoxy-substituted aldehydes Journal of Organic Chemistry 1990 55:4117-4126 DOI:10.1021/jo00300a032
- Roush, W. R., Hoong, L. K., Palmer, M. A. J., Park, J. C. Asymmetric synthesis using tartrate ester modified allylboronates.1. Factors influencing stereoselectivity Journal of Organic Chemistry 1990 55:4109-4117 DOI:10.1021/jo00300a031
- Roush, W. R., Park, J. C. Use of metal carbonyl complexes to achieve high enantioselectivity in the asymmetric allylboration of unsaturated aldehydes Journal of Organic Chemistry 1990 55:1143-1144 DOI:10.1021/jo00291a009
- Roush, W. R., Park, J. C. Asymmetric allylborations of diene aldehyde Fe(CO)3 derivatives: efficient kinetic resolution of racemic complexes and the highly enantiotopic group and face selective allylboration of a meso substrate Tetrahedron Letters 1990 31:4707-4710 DOI:10.1016/s0040-4039(00)97712-8
- Roush, W. R., Grover, P. T. Diisopropyl tartrate (E)-γ-(dimethylphenylsilyl)allylboronate, a chiral allylic alcohol β-carbanion equivalent for the enantioselective synthesis of 2-butene-1,4-diols from aldehydes Tetrahedron Letters 1990 31:7567-7570 DOI:10.1016/s0040-4039(00)97300-3
- Roush, W. R., Grover, P. T., Lin, X. F. Diisopropyl tartrate modified (E)-γ-[(cyclohexyloxy)dimethylsilyl-allylboronate, a chiral reagent for the stereoselective synthesis of anti 1,2-diols via the formal α-hydroxyallylation of aldehydes Tetrahedron Letters 1990 31:7563-7566 DOI:10.1016/s0040-4039(00)97299-x
- Roush, W. R. Stereochemical and synthetic studies of the intramolecular Diels-Alder reaction Advances in Cycloaddition 1990 2:91-146
- Roush, W. R., Moriarty, K. J., Brown, B. B. Stereoselective synthesis of (Z,E)-2-bromo-1,3-dienes via the palladium (O) catalyzed cross coupling reactions of 1,1-dibromoolefins and vinylboronic acids Tetrahedron Letters 1990 31:6509-6512 DOI:10.1016/s0040-4039(00)97103-x
- Roush, W. R., Palkowitz, A. D. Synthesis of the C(1)-C(15) segment of streptovaricin D Journal of Organic Chemistry 1989 54:3009-3011 DOI:10.1021/jo00274a008
- Roush, W. R., Michaelides, M. R., Tai, D. F., Lesur, B. M., Chong, W. K. M., Harris, D. J. A highly stereoselective synthesis of (+)-olivin, the aglycon of olivomycin A Journal of the American Chemical Society 1989 111:2984-2995 DOI:10.1021/ja00190a036
- Coe, J. W., Roush, W. R. Studies of an intramolecular Diels-Alder approach to the nargenicins: involvement of boatlike transition states in the cyclizations of substituted 1,7,9-decatrien-3-ones Journal of Organic Chemistry 1989 54:915-930 DOI:10.1021/jo00265a036
- Roush, W. R. Applications of allylboronates in the synthesis of carbohydrates and polyhydroxylated natural products ACS Symposium Series 1989 386:242-277 DOI:10.1021/bk-1989-0386.ch014
- Roush, W. R., Brown, B. B. Diastereoselective synthesis of the top half of kijanolide Tetrahedron Letters 1989 30:7309-7312 DOI:10.1016/s0040-4039(00)70684-8
- Roush, W. R. Evolution of a strategy for the synthesis of olivomycin A: development of methodology for the diastereo- and enantioselective synthesis of carbohydrates from acyclic precursors Strategies and Tactics in Organic Synthesis 1989 323-367
- Roush, W. R., Essenfeld, A. P., Warmus, J. S., Brown, B. B. Synthesis and Diels-Alder reactions of 2-alkyl-5-methylene-1,3-dioxolan-4-ones and 2-alkyl-3-acyl-5-methylene-1,3-oxazolidin-4-ones: highly exo and diastereoface selective chiral ketene equivalents Tetrahedron Letters 1989 30:7305-7308 DOI:10.1016/s0040-4039(00)70683-6
- Roush, W. R., Banfi, L., Park, J. C., Hoong, L. K. The asymmetric allylboration reaction: dependence of rate and enantioselectivity on the chiral auxiliary Tetrahedron Letters 1989 30:6457-6460 DOI:10.1016/s0040-4039(01)88993-0
- Roush, W. R., Banfi, L. N,N'-dibenzyl-N,N'-ethylenetartramide: a rationally designed chiral auxiliary for the allylboration reaction Journal of the American Chemical Society 1988 110:3979-3982 DOI:10.1021/ja00220a041
- Roush, W. R., Riva, R. Enantioselective synthesis of the bottom half of chlorothricolide. 2. A comparative study of substituent effects on the stereoselectivity of the key intramolecular Diels-Alder reaction Journal of Organic Chemistry 1988 53:710-712 DOI:10.1021/jo00238a049
- Roush, W. R., Brown, B. B., Drozda, S. E. A highly stereoselective synthesis of the octahydronaphthalene subunit of kijanolide and tetronolide Tetrahedron Letters 1988 29:3541-3544 DOI:10.1016/0040-4039(88)85287-0
- Roush, W. R., Ando, K., Powers, D. B., Halterman, R. L., Palkowitz, A. D. Enantioselective synthesis using diisopropyl tartrate modified (E)- and (Z)-crotylboronates: reactions with achiral aldehydes Tetrahedron Letters 1988 29:5579-5582 DOI:10.1016/s0040-4039(00)80816-3
- Roush, W. R., Michaelides, M. R., Tai, D. F., Chong, W. K. M. A highly stereoselective total synthesis of the natural enantiomer of olivin Journal of the American Chemical Society 1987 109:7575-7577 DOI:10.1021/ja00258a077
- Halterman, R. L., Roush, W. R., Hoong, L. K. Analytical resolution of secondary methyl ethers by chiral complexation gas chromatography Journal of Organic Chemistry 1987 52:1152-1155 DOI:10.1021/jo00382a036
- Roush, W. R., Palkowitz, A. D. Applications of tartrate ester modified allylic boronates in organic-synthesis: an efficient, highly stereoselective synthesis of the C19-C29 segment of rifamycin S Journal of the American Chemical Society 1987 109:953-955 DOI:10.1021/ja00237a082
- Roush, W. R., Palkowitz, A. D., Palmer, M. A. J. Reactions of diisopropyl tartrate modified allyl- and (E)- and (Z)-crotylboronates with beta-alkoxy-alpha-methylpropionaldehydes: a reagent-based solution to the acyclic dipropionate problem Journal of Organic Chemistry 1987 52:316-318 DOI:10.1021/jo00378a041
- Roush, W. R., Essenfeld, A. P., Warmus, J. S. Effect of dienophile activating group on the stereoselectivity of the intramolecular Diels-Alder reaction Tetrahedron Letters 1987 28:2447-2450 DOI:10.1016/s0040-4039(00)95437-6
- Roush, W. R., Coe, J. W. Studies on the synthesis of nargenicin A(1). An example of anintramolecular Diels-Alder reaction that proceeds with a boat-likeconformation of the connecting chain Tetrahedron Letters 1987 28:931-934 DOI:10.1016/s0040-4039(00)95877-5
- Roush, W. R., Straub, J. A., Brown, R. J. Total synthesis of carbohydrates. 5. Stereochemistry of the epoxidations of acyclic allylic amides. Applications towards the synthesis of 2,3,6-trideoxy-3-aminohexoses Journal of Organic Chemistry 1987 52:5127-5136 DOI:10.1021/jo00232a014
- Roush, W. R., Russorodriguez, S. Trichothecene degradation studies. 2. Synthesis of [13-(14)-C] anguidine Journal of Organic Chemistry 1987 52:598-603 DOI:10.1021/jo00380a021
- Roush, W. R., Russorodriguez, S. Trichothecene degradation studies. 3. Synthesis of 12,13-deoxy-12,13-methanoanguidine and 12-epianguidine, two optically active analogs of the epoxytrichothecene mycotoxin anguidine Journal of Organic Chemistry 1987 52:603-606 DOI:10.1021/jo00380a022
- Roush, W. R., Adam, M. A., Walts, A. E., Harris, D. J. Stereochemistry of the reactions of substituted allylboronates with chiral aldehydes: factors influencing aldehyde diastereofacial selectivity Journal of the American Chemical Society 1986 108:3422-3434 DOI:10.1021/ja00272a043
- Roush, W. R., Halterman, R. L. Diisopropyl tartrate modified (E)-crotylboronates: highly enantioselective propionate (E)-enolate equivalents Journal of the American Chemical Society 1986 108:294-296 DOI:10.1021/ja00262a018
- Roush, W. R., Michaelides, M. R. Studies on the total synthesis of sesbanimide: highly diastereoselective synthesis of the AB ring system Tetrahedron Letters 1986 27:3353-3356 DOI:10.1016/s0040-4039(00)84794-2
- Roush, W. R., Straub, J. A. Total synthesis of the AB disaccharide unit of olivomycin A Tetrahedron Letters 1986 27:3349-3352 DOI:10.1016/s0040-4039(00)84793-0
- Roush, W. R., Russorodriguez, S. Trichothecene degradation studies: synthesis of 12,13-deoxyanguidine and 12,13-deoxyverrucarol Journal of Organic Chemistry 1985 50:5465-5468 DOI:10.1021/jo00350a004
- Roush, W. R., Walts, A. E., Hoong, L. K. Diastereoselective and enantioselective aldehyde addition-reactions of 2-allyl-1,3,2-dioxaborolane-4,5-dicarboxylic esters, a useful class of tartrate ester modified allylboronates Journal of the American Chemical Society 1985 107:8186-8190 DOI:10.1021/ja00312a062
- Walts, A. E., Roush, W. R. A stereorational total synthesis of (-)-ptilocaulin Tetrahedron 1985 41:3463-3478 DOI:10.1016/s0040-4020(01)96701-8
- Roush, W. R., Adam, M. A. Directed openings of 2,3-epoxy alcohols via reactions with isocyanates: synthesis of (+)-erythro-dihydrosphingosine Journal of Organic Chemistry 1985 50:3752-3757 DOI:10.1021/jo00220a015
- Roush, W. R., Kageyama, M. Enantioselective synthesis of the bottom half of chlorothricolide Tetrahedron Letters 1985 26:4327-4330 DOI:10.1016/s0040-4039(00)98725-2
- Roush, W. R., Adam, M. A., Harris, D. J. Stereochemistry of crotylboronate additions to alpha,beta-dialkoxy aldehydes Journal of Organic Chemistry 1985 50:2000-2003 DOI:10.1021/jo00211a051
- Roush, W. R., Walts, A. E. Stereochemistry of the reactions of pinacol allylboronate with two α,β-dialkoxyaldehydes Tetrahedron Letters 1985 26:3427-3430 DOI:10.1016/s0040-4039(00)98655-6
- Roush, W. R., Russorodriguez, S. Synthesis of 4-beta-acetoxyscirpene-3-alpha,15-diol Journal of Organic Chemistry 1985 50:3224-3226 DOI:10.1021/jo00217a046
- Roush, W. R., Hagadorn, S. M. Synthesis of mycarose and epi-axenose from non-carbohydrate precursors Carbohydrate Research 1985 136:187-193 DOI:10.1016/0008-6215(85)85195-8 PMID:4005889
- Roush, W. R., Marletta, M. A., Russo-Rodriguez, S., Recchia, J. Trichothecene metabolism studies. 2. Structure of 3α-(1'β-D-glucopyranosiduronyl)-8α-isovaleryloxyscirpen-3,4β,15-triol 15-acetate produced from T-2 toxin in vitro Tetrahedron Letters 1985 26:5231-5234 DOI:10.1016/S0040-4039(00)95002-0
- Roush, W. R., Marletta, M. A., Russo-Rodriguez, S., Recchia, J. Trichothecene metabolism studies: isolation and structure determination of 15-acetyl-3α-(1'β-D-glucopyranosiduronyl)scirpen-3,4β,15-triol Journal of the American Chemical Society 1985 107:3354-3355 DOI:10.1021/ja00297a055
- Blanchette, M. A., Choy, W., Davis, J. T., Essenfeld, A. P., Masamune, S., Roush, W. R., Sakai, T. Horner-Wadsworth-Emmons reaction: use of lithium chloride and an amine for base-sensitive compounds Tetrahedron Letters 1984 25:2183-2186 DOI:10.1016/s0040-4039(01)80205-7
- Roush, W. R., Gillis, H. R., Essenfeld, A. P. Hydrofluoric acid catalyzed intramolecular Diels-Alder reactions Journal of Organic Chemistry 1984 49:4674-4682 DOI:10.1021/jo00198a018
- Roush, W. R., Peseckis, S. M., Walts, A. E. Synthesis of antibiotic X-14547A Journal of Organic Chemistry 1984 49:3429-3432 DOI:10.1021/jo00192a052
- Roush, W. R., Blizzard, T. A. Synthesis of epoxytrichothecenes: verrucarin J and verrucarin J isomers Journal of Organic Chemistry 1984 49:1772-1783 DOI:10.1021/jo00184a021
- Roush, W. R., Blizzard, T. A. Synthesis of verrucarin B Journal of Organic Chemistry 1984 49:4332-4339 DOI:10.1021/jo00197a002
- Roush, W. R., Walts, A. E. Total synthesis of (-)-ptilocaulin Journal of the American Chemical Society 1984 106:721-723 DOI:10.1021/ja00315a044
- Roush, W. R., Adam, M. A., Peseckis, S. M. Regioselectivity of the reactions of trialkylaluminum reagents with 2,3-epoxyalcohols: application to the synthesis of α-chiral aldehydes Tetrahedron Letters 1983 24:1377-1380 DOI:10.1016/s0040-4039(00)81660-3
- Roush, W. R., Lesur, B. M. Stereochemistry of vinyl cuprate additions to carbohydrate-derived enones and α,β-unsaturated esters Tetrahedron Letters 1983 24:2231-2234 DOI:10.1016/s0040-4039(00)81891-2
- Roush, W. R., Harris, D. J., Lesur, B. M. Studies on the synthesis of olivin: diastereoselective synthesis of a functionalized D-fucose derivative Tetrahedron Letters 1983 24:2227-2230 DOI:10.1016/s0040-4039(00)81890-0
- Roush, W. R., Spada, A. P. Synthesis of trichoverrol B Tetrahedron Letters 1983 24:3693-3696 DOI:10.1016/s0040-4039(00)94511-8
- Roush, W. R., Blizzard, T. A. Synthesis of verrucarin J Journal of Organic Chemistry 1983 48:758-759 DOI:10.1021/jo00153a035
- Roush, W. R., Dambra, T. E. Total synthesis of (+/-)-verrucarol Journal of the American Chemical Society 1983 105:1058-1060 DOI:10.1021/ja00342a071
- Roush, W. R., Brown, R. J., Dimare, M. Total synthesis of carbohydrates. 2. Regiochemical control of nucleophilic ring opening of acylated 2,3-epoxy alcohols Journal of Organic Chemistry 1983 48:5083-5093 DOI:10.1021/jo00173a056
- Roush, W. R., Brown, R. J. Total synthesis of carbohydrates. 3. Efficient enantioselective syntheses of 2,6-dideoxyhexoses Journal of Organic Chemistry 1983 48:5093-5101 DOI:10.1021/jo00173a057
- Roush, W. R., Spada, A. P. Enantioselective and stereoselective syntheses of the dihydroxyoctadienoic acid fragments of the roridins and trichoverrins Tetrahedron Letters 1982 23:3773-3776 DOI:10.1016/s0040-4039(00)87703-5
- Roush, W. R., Gillis, H. R. Further stereochemical aspects of intramolecular Diels-Ader reactions in the undeca-2,8,10-trienoate ester series Journal of Organic Chemistry 1982 47:4825-4829 DOI:10.1021/jo00146a001
- Roush, W. R., Blizzard, T. A., Basha, F. Z. Methodology for the synthesis of the acyclic portions of verrucarins A and J Tetrahedron Letters 1982 23:2331-2334 DOI:10.1016/s0040-4039(00)87334-7
- Roush, W. R., Gillis, H. R., Ko, A. I. Stereochemical aspects of the intramolecular Diels-Alder reactions of deca-2,7,9-trienoate esters. 3. Thermal, Lewis acid-catalyzed, and asymmetric cyclizations Journal of the American Chemical Society 1982 104:2269-2283 DOI:10.1021/ja00372a027
- Roush, W. R., Peseckis, S. M. Studies on the total synthesis of antibiotic X-14547A: the pentaene approach Tetrahedron Letters 1982 23:4879-4882 DOI:10.1016/s0040-4039(00)85737-8
- Hall, S. E., Roush, W. R. Synthesis of the bottom half of chlorothricolide Journal of Organic Chemistry 1982 47:4611-4621 DOI:10.1021/jo00145a002
- Roush, W. R., Brown, R. J. Total synthesis of carbohydrates: stereoselective syntheses of 2,6-dideoxy-D-arabino-hexose and 2,6-dideoxy-D-ribo-hexose Journal of Organic Chemistry 1982 47:1371-1373 DOI:10.1021/jo00346a050
- Roush, W. R., Myers, A. G. Antibiotic X-14547A: total synthesis of the right-hand half Journal of Organic Chemistry 1981 46:1509-1511 DOI:10.1021/jo00320a060
- Roush, W. R., Peseckis, S. M. Intramolecular Diels-Alder reactions: the angularly methylated trans-perhydroindan ring system Journal of the American Chemical Society 1981 103:6696-6704 DOI:10.1021/ja00412a027
- Roush, W. R., Hall, S. E. Studies on the total synthesis of chlorothricolide: stereochemical aspects of the intramolecular Diels-Alder reactions of methyl undeca-2,8,10-trienoates Journal of the American Chemical Society 1981 103:5200-5211 DOI:10.1021/ja00407a042
- Roush, W. R., Dambra, T. E. Synthesis of a bicyclic precursor to verrucarol: application of a trimethylsilyl-controlled Diels-Alder reaction and Wagner-Meerwein rearrangement sequence Journal of Organic Chemistry 1981 46:5045-5047 DOI:10.1021/jo00337a059
- Roush, W. R., Gillis, H. R. Improved synthesis of the perhydroindenone precursor of dendrobine Journal of Organic Chemistry 1980 45:4283-4287 DOI:10.1021/jo01310a006
- Roush, W. R., Ko, A. I., Gillis, H. R. Stereochemical aspects of the intramolecular Diels-Alder reactions of methyl deca-2,7,9-trienoates. 1. Thermal cyclizations Journal of Organic Chemistry 1980 45:4264-4267 DOI:10.1021/jo01309a054
- Roush, W. R., Gillis, H. R., Hall, S. E. Stereoselective syntheses of substituted methyl (Z,E,E)-deca-2,7.9-trienoates and substituted methyl (Z,E,E)-undeca-2,8,10-trienoates Tetrahedron Letters 1980 21:1023-1026 DOI:10.1016/s0040-4039(00)78829-0
- Roush, W. R. Total synthesis of (+/-)-dendrobine Journal of the American Chemical Society 1980 102:1390-1404 DOI:10.1021/ja00524a027
- Roush, W. R., Dambra, T. E. Total synthesis of verrucarol: a stereoselective synthesis of 13,14-dinor-15-hydroxytrichothec-9-ene Journal of Organic Chemistry 1980 45:3927-3929 DOI:10.1021/jo01307a045
- Roush, W. R. Stereochemical aspects of the intramolecular Diels-Alder reactions of methyl (E,E,E)- and (Z,E,E)-6-alkoxy-11-methyldodeca-2,7,9-trienoate Journal of Organic Chemistry 1979 44:4008-4010 DOI:10.1021/jo01336a067
- Roush, W. R. Total synthesis of (+/-)-dendrobine Journal of the American Chemical Society 1978 100:3599-3601 DOI:10.1021/ja00479a053
- Roush, W. R., Feitler, D., Rebek, J. Polymer-bound tosyl azide Tetrahedron Letters 1974 1391-1392 DOI:10.1016/S0040-4039(01)82499-0
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chapter
- Nanna, A. R., Roush, W. R., Rader, C. Chemical assembly of antibody-drug conjugates Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins. 1-28. 2017
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report
- Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Allais, C., Ouizem, S., Saldanha, S. A., Ferguson, J., Mercer, B. A., Michael, C., et al. ML346: A novel modulator of proteostasis for protein conformational diseases 2010
- Minond, D., Saldanha, S. A., Spicer, T., Qin, L., Mercer, B. A., Roush, W. R., Hodder, P. HTS assay for discovery of novel metallo-beta-lactamase (MBL) inhibitors Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:21961119
- Busby, S., Nuhant, P., Cameron, M., Mercer, B. A., Hodder, P., Roush, W. R., Griffin, P. R. Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2) 2010
- Kumar, N., Nuhant, P., Solt, L. A., Conkright, J. J., Wang, Y., Istrate, M. A., Busby, S. A., Ruben, D. G. O., Burris, T. P., Cameron, M., Mercer, B. A., Hodder, P., et al. Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORalpha) 2010
- Simanski, S., Madoux, F., Rahaim, R. J., Chase, P., Schurer, S., Cameron, M., Mercer, B. A., Hodder, P., Roush, W. R., Ayad, N. G. Identification of small molecule inhibitors of Wee1 degradation and mitotic entry 2010
- Kota, S., Madoux, F., Chase, P., Takahashi, V., Liu, Q., Mercer, B. A., Cameron, M., Strosberg, A. D., Roush, W., Hodder, P. ML322, a small molecule inhibitor of dimerization of the core protein of hepatitis C virus (HCV) 2010
- Cameron, M., Kamenecka, T., Madoux, F., Chase, P., Roush, W., Hodder, P., Griffin, P. R. ML368 identification of imidazopyridines as selective inhibitors of the cytochrome P450 enzyme CYP3A4 2010
- Spicer, T., Minond, D., Enogieru, I., Saldanha, S. A., Allais, C., Liu, Q., Mercer, B. A., Roush, W. R., Hodder, P. ML302, a novel beta-lactamase (BLA) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010 PMID:23762954
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thesis