recent publications
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academic article
- Chillappagari, S., Muller, C., Mahavadi, P., Guenther, A., Nahrlich, L., Rosenblum, J., Rubin, B. K., Henke, M. O. A small molecule neutrophil elastase inhibitor, KRP-109, inhibits cystic fibrosis mucin degradation Journal of Cystic Fibrosis 2016 15:325-331 DOI:10.1016/j.jcf.2015.10.008 PMID:26526358
- Nomanbhoy, T. K., Sharma, G., Brown, H., Wu, J., Aban, A., Vogeti, S., Alemayehu, S., Sykes, M., Rosenblum, J. S., Kozarich, J. W. Chemoproteomic evaluation of target engagement by the cyclin-dependent kinase 4 and 6 inhibitor palbociclib correlates with cancer cell response Biochemistry 2016 55:5434-5441 DOI:10.1021/acs.biochem.6b00629 PMID:27571378
- Lin, E. C. K., Amantea, C. M., Nomanbhoy, T. K., Weissig, H., Ishiyama, J., Hu, Y., Sidique, S., Li, B., Kozarich, J. W., Rosenblum, J. S. ERK5 kinase activity is dispensable for cellular immune response and proliferation Proceedings of the National Academy of Sciences of the United States of America 2016 113:11865-11870 DOI:10.1073/pnas.1609019113 PMID:27679845 PMCID:PMC5081620
- Okerberg, E. S., Hainley, A., Brown, H., Aban, A., Alemayehu, S., Shih, A., Wu, J., Patricelli, M. P., Kozarich, J. W., Nomanbhoy, T., Rosenblum, J. S. Identification of a tumor specific, active-site mutation in casein kinase 1α by chemical proteomics PLoS One 2016 11 DOI:10.1371/journal.pone.0152934 PMID:27031502
- Nordin, B. E., Liu, Y., Aban, A., Brown, H. E., Wu, J., Hainley, A. K., Rosenblum, J. S., Nomanbhoy, T. K., Kozarich, J. W. ATP acyl phosphate reactivity reveals native conformations of Hsp90 para logs and inhibitor target engagement Biochemistry 2015 54:3024-3036 DOI:10.1021/acs.biochem.5b00148
- Okerberg, E. S., Brown, H. E., Minimo, L., Alemayehu, S., Rosenblum, J., Patricelli, M., Nomanbhoy, T., Kozarich, J. W. Monitoring native p38α:MK2/3 complexes via trans delivery of an ATP acyl phosphate probe Journal of the American Chemical Society 2014 136:4664-4669 DOI:10.1021/ja4129907 PMID:24601623
- Harstad, E. B., Rosenblum, J. S., Gorrell, M. D., Achanzar, W. E., Minimo, L., Wu, J., Rosini-Marthaler, L., Gullo, R., Ordway, N. D., Kirby, M. S., Chadwick, K. D., Cosma, G. N., et al. DPP8 and DPP9 expression in cynomolgus monkey and Sprague Dawley rat tissues Regulatory Peptides 2013 186:26-35 DOI:10.1016/j.regpep.2013.07.003 PMID:23850796
- Rosenblum, J. S., Nomanbhoy, T. K., Kozarich, J. W. Functional interrogation of kinases and other nucleotide-binding proteins FEBS Letters 2013 587:1870-1877 DOI:10.1016/j.febslet.2013.05.008 PMID:23684650
- Shreder, K. R., Lin, E. C. K., Wu, J., Cajica, J., Amantea, C. M., Hu, Y., Okerberg, E., Brown, H. E., Pham, L. M., Chung, D. M., Fraser, A. S., McGee, E., et al. Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1/AADACL1) Bioorganic & Medicinal Chemistry Letters 2012 22:5748-5751 DOI:10.1016/j.bmcl.2012.05.102 PMID:22877630
- Chaves, S. R., Rosenblum, J. S. Efficient nuclear transport of structurally disturbed cargo: mutations in a cargo protein switch its cognate karyopherin PLoS One 2011 6 DOI:10.1371/journal.pone.0016846 PMID:21347375 PMCID:PMC3036716
- Cociorva, O. M., Li, B., Nomanbhoy, T., Li, Q., Nakamura, A., Nakamura, K., Nomura, M., Okada, K., Seto, S., Yumoto, K., Liyanage, M., Zhang, M. C., et al. Synthesis and structure-activity relationship of 4-quinolone-3-carboxylic acid based inhibitors of glycogen synthase kinase-3 beta Bioorganic & Medicinal Chemistry Letters 2011 21:5948-5951 DOI:10.1016/j.bmcl.2011.07.073 PMID:21873061
- Miyazaki, M., Rosenblum, J. S., Kasahara, Y., Nakagawa, I., Patricelli, M. P. Determination of enzymatic source of alanine aminotransferase activity in serum from dogs with liver injury Journal of Pharmacological and Toxicological Methods 2009 60:307-315 DOI:10.1016/j.vascn.2009.09.001 PMID:19748590
- Liu, Y., Jiang, N., Wu, J., Dai, W., Rosenblum, J. S. Polo-like kinases inhibited by Wortmannin. Labeling site and downstream effects Journal of Biological Chemistry 2007 282:2505-2511 DOI:10.1074/jbc.M609603200 PMID:17135248
- Danilova, O., Li, B., Szardenings, A. K., Huber, B. T., Rosenblum, J. S. Synthesis and activity of a potent, specific azabicyclo[3.3.0]-octane-based DPP II inhibitor Bioorganic & Medicinal Chemistry Letters 2007 17:507-510 DOI:10.1016/j.bmcl.2006.10.012 PMID:17055271 PMCID:PMC1828633
- Shreder, K. R., Wong, M. S., Corral, S., Yu, Z., Winn, D. T., Wu, M., Hu, Y., Nomanbhoy, T., Alemayehu, S., Fuller, S. R., Rosenblum, J. S., Kozarich, J. W. Boro-norleucine as a P1 residue for the design of selective and potent DPP7 inhibitors Bioorganic & Medicinal Chemistry Letters 2005 15:4256-4260 DOI:10.1016/j.bmcl.2005.06.076 PMID:16084722
- Hu, Y., Ma, L., Wu, M., Wong, M. S., Li, B., Corral, S., Yu, Z., Nomanbhoy, T., Alemayehu, S., Fuller, S. R., Rosenblum, J. S., Rozenkrants, N., et al. Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7 Bioorganic & Medicinal Chemistry Letters 2005 15:4239-4242 DOI:10.1016/j.bmcl.2005.06.075 PMID:16085416
- Liu, Y., Shreder, K. R., Gai, W., Corral, S., Ferris, D. K., Rosenblum, J. S. Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase Chemistry & Biology 2005 12:99-107 DOI:10.1016/j.chembiol.2004.11.009 PMID:15664519
- Baxter, S. M., Rosenblum, J. S., Knutson, S., Nelson, M. R., Montimurro, J. S., Di Gennaro, J. A., Speir, J. A., Burbaum, J. J., Fetrow, J. S. Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast Molecular & Cellular Proteomics 2004 3:209-225 DOI:10.1074/mcp.M300082-MCP200 PMID:14645503
- Nomanbhoy, T. K., Rosenblum, J., Aban, A., Burbaum, J. J. Inhibitor focusing: direct selection of drug targets from proteomes using activity-based probes Assay and Drug Development Technologies 2003 1:137-146 DOI:10.1089/154065803321537854 PMID:15090140
- Rosenblum, J. S., Kozarich, J. W. Proyl peptidases: a serine protease subfamily with high potential for drug discovery Current Opinion in Chemical Biology 2003 7:496-504 DOI:10.1016/s1367-5931(03)00084-x PMID:12941425
- Rosenblum, J. S., Blobel, G. Autoproteolysis in nucleoporin biogenesis Proceedings of the National Academy of Sciences of the United States of America 1999 96:11370-11375 DOI:10.1073/pnas.96.20.11370 PMID:10500183 PMCID:PMC18040
- Pemberton, L. F., Rosenblum, J. S., Blobel, G. Nuclear import of the TATA-binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting Journal of Cell Biology 1999 145:1407-1417 PMID:10385521 PMCID:PMC2133169
- Albertini, M., Pemberton, L. F., Rosenblum, J. S., Blobel, G. A novel nuclear import pathway for the transcription factor TFIIS Journal of Cell Biology 1998 143:1447-1455 PMID:9852143 PMCID:PMC2132971
- Rosenblum, J. S., Pemberton, L. F., Bonifaci, N., Blobel, G. Nuclear import and the evolution of a multifunctional RNA-binding protein Journal of Cell Biology 1998 143:887-899 PMID:9817748 PMCID:PMC2132966
- Pemberton, L. F., Blobel, G., Rosenblum, J. S. Transport routes through the nuclear pore complex Current Opinion in Cell Biology 1998 10:392-399 DOI:10.1016/S0955-0674(98)80016-1 PMID:9640541
- Pemberton, L. F., Rosenblum, J. S., Blobel, G. A distinct and parallel pathway for the nuclear import of an mRNA-binding protein Journal of Cell Biology 1997 139:1645-1653 PMID:9412460 PMCID:PMC2132632
- Rosenblum, J. S., Pemberton, L. F., Blobel, G. A nuclear import pathway for a protein involved in tRNA maturation Journal of Cell Biology 1997 139:1655-1661 PMID:9412461 PMCID:PMC2132634
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Rosenblum, J. S., Gilula, N. B., Lerner, R. A.
On signal sequence polymorphisms and diseases of distribution
Proceedings of the National Academy of Sciences of the United States of America
1996
93:4471-4473
DOI:10.1073/pnas.93.9.4471
PMID:8633092
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Rosenblum, J. S., Lo, L. C., Li, T. Y., Janda, K. D., Lerner, R. A.
Antibody-catalyzed phosphate triester hydrolysis
Angewandte Chemie-International Edition
1995
34:2275-2277
DOI:10.1002/anie.199522751
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Barbas, C. F., Rosenblum, J. S., Lerner, R. A.
Direct selection of antibodies that coordinate metals from semisynthetic combinatorial libraries
Proceedings of the National Academy of Sciences of the United States of America
1993
90:6385-6389
PMID:8341642
PMCID:PMC46936