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Rosen, Hugh
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Rosen, Hugh

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Faculty Member
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Positions

  • 2017 - Professor, Molecular Medicine , Scripps Research
  • 2002 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2007 - 2017 Professor, Chemical Physiology , Scripps Research
  • 2002 - 2007 Professor, Immunology and Microbial Science (IMS) , Scripps Research
  • 2000 - 2002 Executive Director, Immunology & Rheumatology, Merck & Co., Inc.
  • 1999 - 2000 Executive Director, Infectious Diseases, Merck & Co., Inc.
  • 1997 - 1998 Senior Director, Antibiotic Discovery & Development, Merck & Co., Inc.
  • 1994 - 1997 Director, Antibiotic Discovery & Development, Merck & Co., Inc.
  • 1994 Senior Research Fellow, Inflammation and Immunology, Merck & Co., Inc.
  • 1990 - 1994 Research Fellow, Inflammation and Immunology, Merck & Co., Inc.
Dr. Hugh Rosen uses chemical and biological approaches to define and manipulate the molecular gatekeepers regulating cell trafficking in the immune system, including sphingosine 1-phosphate receptors; this work defines links between innate and adaptive immunity and develops novel approaches to immunosuppression that may be therapeutically useful.

Contact

  • hrosen@scripps.edu

Websites

  • Hugh Rosen, M.D., Ph.D.
  • Laboratory Website
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Publications

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    • Huppe, C. A., Blais-Lecours, P., Bernatchez, E., Lauzon-Joset, J. F., Duchaine, C., Rosen, H., Dion, G., McNagny, K. M., Blanchet, M. R., Morissette, M. C., Marsolais, D. S1P(1) Contributes to Endotoxin-enhanced B-Cell Functions Involved in Hypersensitivity Pneumonitis American Journal of Respiratory Cell and Molecular Biology  2020 63:209-218  DOI:10.1165/rcmb.2019-0339OC  PMID:32289229  PMCID:PMC7464516
    • Page, S., Mavrikaki, M. M., Lintz, T., Puttick, D., Roberts, E., Rosen, H., Carroll, F. I., Carlezon, W. A., Chartoff, E. H. Behavioral pharmacology of novel kappa opioid receptor antagonists in rats International Journal of Neuropsychopharmacology  2019 22:735-745  DOI:10.1093/ijnp/pyz054  PMID:31613314
    • Morgan, G. J., Yan, N. L., Mortenson, D. E., Rennella, E., Blundon, J. M., Gwin, R. M., Lin, C. Y., Stanfield, R. L., Brown, S. J., Rosen, H., Spicer, T. P., Fernandez-Vega, V., et al. Stabilization of amyloidogenic immunoglobulin light chains by small molecules Proceedings of the National Academy of Sciences of the United States of America  2019 116:8360-8369  DOI:10.1073/pnas.1817567116  PMID:30971495  PMCID:PMC6486714
    • Baillargeon, P., Fernandez-Vega, V., Sridharan, B. P., Brown, S., Griffin, P. R., Rosen, H., Cravatt, B., Scampavia, L., Spicer, T. P. The Scripps Molecular Screening Center and Translational Research Institute SLAS Discovery  2019 24:386-397  DOI:10.1177/2472555218820809  PMID:30682260
    • Guerrero, M., Urbano, M., Kim, E. K., Gamo, A. M., Riley, S., Abgaryan, L., Leaf, N., Van Orden, L. J., Brown, S. J., Xie, J. Y., Porreca, F., Cameron, M. D., et al. Design and synthesis of a novel and selective kappa opioid receptor (KOR) antagonist (BTRX-335140) Journal of Medicinal Chemistry  2019 62:1761-1780  DOI:10.1021/acs.jmedchem.8b01679  PMID:30707578  PMCID:PMC6395531
    • Ogasawara, D., Ichu, T. A., Vartabedian, V. F., Benthuysen, J., Jing, H., Reed, A., Ulanovskaya, O. A., Hulce, J. J., Roberts, A., Brown, S., Rosen, H., Teijaro, J. R., et al. Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo Nature Chemical Biology  2018 14:1099-1108  DOI:10.1038/s41589-018-0155-8  PMID:30420694  PMCID:PMC6263940
    • Huppe, C. A., Lecours, P. B., Lechasseur, A., Gendron, D. R., Lemay, A. M., Bissonnette, E. Y., Blanchet, M. R., Duchaine, C., Morissette, M. C., Rosen, H., Marsolais, D. A sphingosine-1-phosphate receptor 1 agonist inhibits tertiary lymphoid tissue reactivation and hypersensitivity in the lung Mucosal Immunology  2018 11:112-119  DOI:10.1038/mi.2017.37  PMID:28422187
    • Song, J., Dagan, A., Yakhtin, Z., Gatt, S., Riley, S., Rosen, H., Or, R., Almogi-Hazan, O. The novel sphingosine-1-phosphate receptors antagonist AD2900 affects lymphocyte activation and inhibits T-cell entry into the lymph nodes Oncotarget  2017 8:53563-53580  DOI:10.18632/oncotarget.18626
    • Tran, J. Q., Hartung, J. P., Peach, R. J., Boehm, M. F., Rosen, H., Smith, H., Brooks, J. L., Timony, G. A., Olson, A. D., Gujrathi, S., Frohna, P. A. Results from the first-in-human study with ozanimod, a novel, selective sphingosine-1-phosphate receptor modulator Journal of Clinical Pharmacology  2017 57:988-996  DOI:10.1002/jcph.887  PMID:28398597  PMCID:PMC5516232
    • Xie, J. Y., De Felice, M., Kopruszinski, C. M., Eyde, N., LaVigne, J., Remeniuk, B., Hernandez, P., Yue, X., Goshima, N., Ossipov, M., King, T., Streicher, J. M., et al. Kappa opioid receptor antagonists: A possible new class of therapeutics for migraine prevention Cephalalgia  2017 37:780-794  DOI:10.1177/0333102417702120  PMID:28376659
    • Dusaban, S. S., Chun, J., Rosen, H., Purcell, N. H., Brown, J. H. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes Journal of Neuroinflammation  2017 14  DOI:10.1186/s12974-017-0882-x  PMID:28577576  PMCID:PMC5455202
    • Marro, B. S., Ware, B. C., Zak, J., de la Torre, J. C., Rosen, H., Oldstone, M. B. A. Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling Proceedings of the National Academy of Sciences of the United States of America  2017 114:3708-3713  DOI:10.1073/pnas.1700878114  PMID:28325871  PMCID:PMC5389329
    • Yung, B. S., Brand, C. S., Xiang, S. Y., Gray, C. B. B., Means, C. K., Rosen, H., Chun, J., Purcell, N. H., Brown, J. H., Miyamoto, S. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection Journal of Molecular and Cellular Cardiology  2017 103:1-10  DOI:10.1016/j.yjmcc.2016.12.008  PMID:28017639
    • Skerry, C., Scanlon, K., Ardanuy, J., Roberts, D., Zhang, L., Rosen, H., Carbonetti, N. H. Reduction of pertussis inflammatory pathology by therapeutic treatment with sphingosine-1-phosphate receptor ligands by a pertussis toxin-insensitive mechanism Journal of Infectious Diseases  2017 215:278-286  DOI:10.1093/infdis/jiw536  PMID:27815382
    • Hur, W., Rosen, H., Gray, N. S. A benzo[b]thiophene-based selective type 4 S1P receptor agonist Bioorganic & Medicinal Chemistry Letters  2017 27:1-5  DOI:10.1016/j.bmcl.2016.11.050  PMID:27894870
    • Karuppuchamy, T., Behrens, E. H., Gonzalez-Cabrera, P., Sarkisyan, G., Gima, L., Boyer, J. D., Bamias, G., Jedlicka, P., Veny, M., Clark, D., Peach, R., Scott, F., et al. Sphingosine-1-phosphate receptor-1 (S1P1) is expressed by lymphocytes, dendritic cells, and endothelium and modulated during inflammatory bowel disease Mucosal Immunology  2017 10:162-171  DOI:10.1038/mi.2016.35  PMID:27049060  PMCID:PMC5053832
    • Johnson, J. L., Ramadass, M., He, J., Brown, S. J., Zhang, J., Abgaryan, L., Biris, N., Gavathiotis, E., Rosen, H., Catz, S. D. Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small GTPase Rab27a Journal of Biological Chemistry  2016 291:25965-25982  DOI:10.1074/jbc.M116.741884  PMID:27702998  PMCID:PMC5207069
    • Horning, B. D., Suciu, R. M., Ghadiri, D. A., Ulanovskaya, O. A., Matthews, M. L., Lum, K. M., Backus, K. M., Brown, S. J., Rosen, H., Cravatt, B. F. Chemical proteomic profiling of human methyltransferases Journal of the American Chemical Society  2016 138:13335-13343  DOI:10.1021/jacs.6b07830  PMID:27689866  PMCID:PMC5072128
    • Ewing, H., Fernandez-Vega, V., Spicer, T. P., Chase, P., Brown, S., Scampavia, L., Roush, W. R., Riley, S., Rosen, H., Hodder, P., Lambeau, G., Gelb, M. H. Fluorometric high-throughput screening assay for secreted phospholipases A(2) using phospholipid vesicles Journal of Biomolecular Screening  2016 21:713-721  DOI:10.1177/1087057116646742  PMID:27146384
    • Plate, L., Cooley, C. B., Chen, J. J., Paxman, R. J., Gallagher, C. M., Madoux, F., Genereux, J. C., Dobbs, W., Garza, D., Spicer, T. P., Scampavia, L., Brown, S. J., et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Elife  2016 5  DOI:10.7554/eLife.15550  PMID:27435961  PMCID:PMC4954754
    • Scott, F. L., Clemons, B., Brooks, J., Brahmachary, E., Powell, R., Dedman, H., Desale, H. G., Timony, G. A., Martinborough, E., Rosen, H., Roberts, E., Boehm, M. F., et al. Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P(1)) and receptor-5 (S1P(5)) agonist with autoimmune disease-modifying activity British Journal of Pharmacology  2016 173:1778-1792  DOI:10.1111/bph.13476  PMID:26990079  PMCID:PMC4867749
    • Teijaro, J. R., Studer, S., Leaf, N., Kiosses, W. B., Nguyen, N., Matsuki, K., Negishi, H., Taniguchi, T., Oldstone, M. B. A., Rosen, H. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-alpha autoamplification Proceedings of the National Academy of Sciences of the United States of America  2016 113:1351-1356  DOI:10.1073/pnas.1525356113  PMID:26787880  PMCID:PMC4747766
    • Sanna, M. G., Vincent, K. P., Repetto, E., Nguyen, N., Brown, S. J., Abgaryan, L., Riley, S. W., Leaf, N. B., Cahalan, S. M., Kiosses, W. B., Kohno, Y., Brown, J. H., et al. Bitopic sphingosine 1-phosphate receptor 3 (S1P3) antagonist rescue from complete heart block: pharmacological and genetic evidence for direct S1P3 regulation of mouse cardiac conduction Molecular Pharmacology  2016 89:176-186  DOI:10.1124/mol.115.100222  PMID:26494861  PMCID:PMC4702096
    • Blanc, C. A., Grist, J. J., Rosen, H., Sears-Kraxberger, I., Steward, O., Lane, T. E. Sphingosine-1-phosphate receptor antagonism enhances proliferation and migration of engrafted neural progenitor cells in a model of viral-induced demyelination American Journal of Pathology  2015 185:2819-2832  DOI:10.1016/j.ajpath.2015.06.009  PMID:26435414  PMCID:PMC4607760
    • Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Correia, B. E., Ichu, T. A., Olucha, J., Brown, S. J., Kundu, S., Piscitelli, F., Rosen, H., Cravatt, B. F. A global map of lipid-binding proteins and their ligandability in cells Cell  2015 161:1668-1680  DOI:10.1016/j.cell.2015.05.045  PMID:26091042  PMCID:PMC4615699
    • Skerry, C., Scanlon, K., Rosen, H., Carbonetti, N. H. Sphingosine-1-phosphate receptor agonism reduces Bordetella pertussis-mediated lung pathology Journal of Infectious Diseases  2015 211:1883-1886  DOI:10.1093/infdis/jiu823  PMID:25538274  PMCID:PMC4836722
    • Schreiber, S. L., Kotz, J. D., Li, M., Aube, J., Austin, C. P., Reed, J. C., Rosen, H., White, E. L., Sklar, L. A., Lindsley, C. W., Alexander, B. R., Bittker, J. A., et al. Advancing biological understanding and therapeutics discovery with small-molecule probes Cell  2015 161:1252-1265  DOI:10.1016/j.cell.2015.05.023  PMID:26046436  PMCID:PMC4564295
    • Chang, J. W., Zuhl, A. M., Speers, A. E., Niessen, S., Brown, S. J., Mulvihill, M. M., Fan, Y. C., Spicer, T. P., Southern, M., Scampavia, L., Fernandez-Vega, V., Dix, M. M., et al. Selective inhibitor of platelet-activating factor acetylhydrolases 1b2 and 1b3 that impairs cancer cell survival ACS Chemical Biology  2015 10:925-932  DOI:10.1021/cb500893q  PMID:25602368  PMCID:PMC4402257
    • Zhao, N., Darby, C. M., Small, J., Bachovchin, D. A., Jiang, X., Burns-Huang, K. E., Botella, H., Ehrt, S., Boger, D. L., Anderson, E. D., Cravatt, B. F., Speers, A. E., et al. Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis ACS Chemical Biology  2015 10:364-371  DOI:10.1021/cb500746z  PMID:25457457  PMCID:PMC4340348
    • Blanc, C. A., Rosen, H., Lane, T. E. FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination Journal of Neuroinflammation  2014 11:138  DOI:10.1186/s12974-014-0138-y  PMID:25138356  PMCID:PMC4148542
    • Sarkisyan, G., Gay, L. J., Nguyen, N., Felding, B. H., Rosen, H. Host endothelial S1PR(1) regulation of vascular permeability modulates tumor growth American Journal of Physiology-Cell Physiology  2014 307:C14-C24  DOI:10.1152/ajpcell.00043.2014  PMID:24740542  PMCID:PMC4080184
    • Walsh, K. B., Teijaro, J. R., Brock, L. G., Fremgen, D. M., Collins, P. L., Rosen, H., Oldstone, M. B. A. Animal model of respiratory syncytial virus: CD8(+) T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy Journal of Virology  2014 88:6281-6293  DOI:10.1128/jvi.00464-14  PMID:24672024
    • Urbano, M., Guerrero, M., Rosen, H., Roberts, E. Antagonists of the kappa opioid receptor Bioorganic & Medicinal Chemistry Letters  2014 24:2021-2032  DOI:10.1016/j.bmcl.2014.03.040  PMID:24690494
    • Ohotski, J., Rosen, H., Bittman, R., Pyne, S., Pyne, N. J. Sphingosine kinase 2 prevents the nuclear translocation of sphingosine 1-phosphate receptor-2 and tyrosine 416 phosphorylated c-Src and increases estrogen receptor negative MDA-MB-231 breast cancer cell growth: the role of sphingosine 1-phosphate receptor-4 Cellular Signalling  2014 26:1040-1047  DOI:10.1016/j.cellsig.2014.01.023  PMID:24486401
    • Teijaro, J. R., Walsh, K. B., Rice, S., Rosen, H., Oldstone, M. B. A. Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection Proceedings of the National Academy of Sciences of the United States of America  2014 111:3799-3804  DOI:10.1073/pnas.1400593111  PMID:24572573  PMCID:PMC3956176
    • Teijaro, J. R., Walsh, K. B., Long, J. P., Tordoff, K. P., Stark, G. V., Eisfeld, A. J., Kawaoka, Y., Rosen, H., Oldstone, M. B. A. Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy Virology  2014 452:152-157  DOI:10.1016/j.virol.2014.01.003  PMID:24606692  PMCID:PMC3954990
    • Oldstone, M. B. A., Rosen, H. Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule Current Topics in Microbiology and Immunology  2014 378:129-147  DOI:10.1007/978-3-319-05879-5_6  PMID:24728596
    • Chang, M. R., Rosen, H., Griffin, P. R. RORs in autoimmune disease Current Topics in Microbiology and Immunology  2014 378:171-182  DOI:10.1007/978-3-319-05879-5_8  PMID:24728598
    • Rosen, H., Sanna, M. G., Gonzalez-Cabrera, P. J., Roberts, E. The organization of the sphingosine 1-phosphate signaling system Current Topics in Microbiology and Immunology  2014 378:1-21  DOI:10.1007/978-3-319-05879-5_1  PMID:24728591
    • Guerrero, M., Poddutoori, R., Urbano, M., Peng, X., Spicer, T. P., Chase, P. S., Hodder, P. S., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, design and synthesis of a selective S1P(3) receptor allosteric agonist Bioorganic & Medicinal Chemistry Letters  2013 23:6346-6349  DOI:10.1016/j.bmcl.2013.09.075  PMID:24135724  PMCID:PMC3963471
    • Urbano, M., Guerrero, M., Rosen, H., Roberts, E. Modulators of the Sphingosine 1-phosphate receptor 1 Bioorganic & Medicinal Chemistry Letters  2013 23:6377-6389  DOI:10.1016/j.bmcl.2013.09.058  PMID:24125884  PMCID:PMC3926431
    • Satsu, H., Schaeffer, M. T., Guerrero, M., Saldana, A., Eberhart, C., Hodder, P., Cayanan, C., Schurer, S., Bhhatarai, B., Roberts, E., Rosen, H., Brown, S. J. A sphingosine 1-phosphate receptor 2 selective allosteric agonist Bioorganic & Medicinal Chemistry  2013 21:5373-5382  DOI:10.1016/j.bmc.2013.06.012  PMID:23849205  PMCID:PMC3786410
    • Hulleman, J. D., Brown, S. J., Rosen, H., Kelly, J. W. A high-throughput cell-based Gaussia luciferase reporter assay for identifying modulators of fibulin-3 secretion Journal of Biomolecular Screening  2013 18:647-658  DOI:10.1177/1087057112469405  PMID:23230284  PMCID:PMC4435789
    • Roberts, E., Guerrero, M., Urbano, M., Rosen, H. Sphingosine 1-phosphate receptor agonists: A patent review (2010 - 2012) Expert Opinion on Therapeutic Patents  2013 23:817-841  DOI:10.1517/13543776.2013.783022  PMID:23541049
    • Cisar, E. A. G., Nguyen, N., Rosen, H. A GTP affinity probe for proteomics highlights flexibility in purine nucleotide selectivity Journal of the American Chemical Society  2013 135:4676-4679  DOI:10.1021/ja400839e  PMID:23473570
    • Matheu, M. P., Teijaro, J. R., Walsh, K. B., Greenberg, M. L., Marsolais, D., Parker, I., Rosen, H., Oldstone, M. B. A., Cahalan, M. D. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy PLoS One  2013 8:e58033  DOI:10.1371/journal.pone.0058033  PMID:23533579  PMCID:PMC3606384
    • Guerrero, M., Urbano, M., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. SAR analysis of novel non-peptidic NPBWR1 (GPR7) antagonists Bioorganic & Medicinal Chemistry Letters  2013 23:614-619  DOI:10.1016/j.bmcl.2012.12.030  PMID:23287738  PMCID:PMC3621982
    • Nagano, J. M. G., Hsu, K. L., Whitby, L. R., Niphakis, M. J., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P., Srinivasan, P., Gonzalez, T. D., et al. Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2) Bioorganic & Medicinal Chemistry Letters  2013 23:839-843  DOI:10.1016/j.bmcl.2012.11.061  PMID:23260346  PMCID:PMC3549684
    • Cahalan, S. M., Gonzalez-Cabrera, P. J., Nguyen, N., Guerrero, M., Cisar, E. A. G., Leaf, N. B., Brown, S. J., Roberts, E., Rosen, H. Sphingosine 1-phosphate receptor 1 (S1P(1)) upregulation and amelioration of experimental autoimmune encephalomyelitis by an S1P(1) antagonist Molecular Pharmacology  2013 83:316-321  DOI:10.1124/mol.112.082958  PMID:23204443  PMCID:PMC3558813
    • Oldstone, M. B. A., Teijaro, J. R., Walsh, K. B., Rosen, H. Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection Virology  2013 435:92-101  DOI:10.1016/j.virol.2012.09.039  PMID:23217619  PMCID:PMC3523270
    • Rosen, H., Stevens, R. C., Hanson, M., Roberts, E., Oldstone, M. B. A. Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence Annual Review of Biochemistry  2013 82:637-662  DOI:10.1146/annurev-biochem-062411-130916  PMID:23527695
    • Stevens, R. C., Cherezov, V., Katritch, V., Abagyan, R., Kuhn, P., Rosen, H., Wuthrich, K. The GPCR Network: a large-scale collaboration to determine human GPCR structure and function Nature Reviews Drug Discovery  2013 12:25-34  DOI:10.1038/nrd3859  PMID:23237917  PMCID:PMC3723354
    • Urbano, M., Guerrero, M., Zhao, J., Velaparthi, S., Saldanha, S. A., Chase, P., Wang, Z. W., Civelli, O., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., et al. Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7) Bioorganic & Medicinal Chemistry Letters  2012 22:7135-7141  DOI:10.1016/j.bmcl.2012.09.074  PMID:23079522  PMCID:PMC3601546
    • Jo, E. J., Bhhatarai, B., Repetto, E., Guerrero, M., Riley, S., Brown, S. J., Kohno, Y., Roberts, E., Schurer, S. C., Rosen, H. Novel selective allosteric and bitopic ligands for the S1P(3) receptor ACS Chemical Biology  2012 7:1975-1983  DOI:10.1021/cb300392z  PMID:22971058  PMCID:PMC3528827
    • Dillon, M. B. C., Bachovchin, D. A., Brown, S. J., Finn, M. G., Rosen, H., Cravatt, B. F., Mowen, K. A. Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization ACS Chemical Biology  2012 7:1198-1204  DOI:10.1021/cb300024c  PMID:22506763  PMCID:PMC3401332
    • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Hodder, P. S., et al. Confirming target engagement for reversible inhibitors in vivo by kinetically tuned activity-based probes Journal of the American Chemical Society  2012 134:10345-10348  DOI:10.1021/ja303400u  PMID:22690931  PMCID:PMC3392194
    • Sarkisyan, G., Cahalan, S. M., Gonzalez-Cabrera, P. J., Leaf, N. B., Rosen, H. Real-time differential labeling of blood, interstitium, and lymphatic and single-field analysis of vasculature dynamics in vivo American Journal of Physiology-Cell Physiology  2012 302:C1460-C1468  DOI:10.1152/ajpcell.00382.2011  PMID:22357735
    • Hanson, M. A., Roth, C. B., Jo, E. J., Griffith, M. T., Scott, F. L., Reinhart, G., Desale, H., Clemons, B., Cahalan, S. M., Schuerer, S. C., Sanna, M. G., Han, G. W., et al. Crystal structure of a lipid G protein-coupled receptor Science  2012 335:851-855  DOI:10.1126/science.1215904  PMID:22344443  PMCID:PMC3338336
    • Gonzalez-Cabrera, P. J., Cahalan, S. M., Nguyen, N., Sarkisyan, G., Leaf, N. B., Cameron, M. D., Kago, T., Rosen, H. S1P(1) receptor modulation with cyclical recovery from lymphopenia ameliorates mouse model of multiple sclerosis Molecular Pharmacology  2012 81:166-174  DOI:10.1124/mol.111.076109  PMID:22031473  PMCID:PMC3263953
    • Guerrero, M., Urbano, M., Zhao, J., Crisp, M., Chase, P., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (s1p(4)-r) agonists Bioorganic & Medicinal Chemistry Letters  2012 22:537-542  DOI:10.1016/j.bmcl.2011.10.096  PMID:22119461  PMCID:PMC3248976
    • Tsuboi, K., Bachovchin, D. A., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Hodder, P., Rosen, H., Cravatt, B. F. Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance Journal of the American Chemical Society  2011 133:16605-16616  DOI:10.1021/ja2066972  PMID:21899313  PMCID:PMC3226709
    • Walsh, K. B., Teijaro, J. R., Rosen, H., Oldstone, M. B. A. Quelling the storm: Utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm Immunologic Research  2011 51:15-25  DOI:10.1007/s12026-011-8240-z  PMID:21901448
    • Teijaro, J. R., Walsh, K. B., Cahalan, S., Fremgen, D. M., Roberts, E., Scott, F., Martinborough, E., Peach, R., Oldstone, M. B. A., Rosen, H. Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Cell  2011 146:979-990  DOI:10.1016/j.cell.2011.08.015  PMID:21925319  PMCID:PMC3176439
    • Urbano, M., Guerrero, M., Zhao, J., Velaparthi, S., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Sar analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (s1p(4)) receptor Bioorganic & Medicinal Chemistry Letters  2011 21:5470-5474  DOI:10.1016/j.bmcl.2011.06.132  PMID:21783362  PMCID:PMC3159836
    • Lone, A. M., Bachovchin, D. A., Westwood, D. B., Speers, A. E., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Rosen, H., Cravatt, B. F., Saghatelian, A. A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors Journal of the American Chemical Society  2011 133:11665-11674  DOI:10.1021/ja2036095  PMID:21692504  PMCID:PMC3145007
    • Bachovchin, D. A., Zuhl, A. M., Speers, A. E., Wolfe, M. R., Weerapana, E., Brown, S. J., Rosen, H., Cravatt, B. F. Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1 Journal of Medicinal Chemistry  2011 54:5229-5236  DOI:10.1021/jm200502u  PMID:21639134  PMCID:PMC3144155
    • Walsh, K. B., Teijaro, J. R., Wilker, P. R., Jatzek, A., Fremgen, D. M., Das, S. C., Watanabe, T., Hatta, M., Shinya, K., Suresh, M., Kawaoka, Y., Rosen, H., et al. Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus Proceedings of the National Academy of Sciences of the United States of America  2011 108:12018-12023  DOI:10.1073/pnas.1107024108  PMID:21715659  PMCID:PMC3142000
    • Guerrero, M., Urbano, M., Velaparthi, S., Zhao, J., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, design and synthesis of the first reported potent and selective sphingosine-1-phosphate 4 (s1p(4)) receptor antagonists Bioorganic & Medicinal Chemistry Letters  2011 21:3632-3636  DOI:10.1016/j.bmcl.2011.04.097  PMID:21570287  PMCID:PMC3107912
    • Cahalan, S. M., Gonzalez-Cabrera, P. J., Sarkisyan, G., Nguyen, N., Schaeffer, M. T., Huang, L. M., Yeager, A., Clemons, B., Scott, F., Rosen, H. Actions of a picomolar short-acting S1P(1) agonist in S1P(1)-eGFP knock-in mice Nature Chemical Biology  2011 7:254-256  DOI:10.1038/nchembio.547  PMID:21445057  PMCID:PMC3430385
    • Bachovchin, D. A., Mohr, J. T., Speers, A. E., Wang, C., Berlin, J. M., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Schurer, S. C., Nomura, D. K., Rosen, H., et al. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors Proceedings of the National Academy of Sciences of the United States of America  2011 108:6811-6816  DOI:10.1073/pnas.1015248108  PMID:21398589  PMCID:PMC3084096
    • Chou, T. F., Brown, S. J., Minond, D., Nordin, B. E., Li, K. L., Jones, A. C., Chase, P., Porubsky, P. R., Stoltz, B. M., Schoenen, F. J., Patricelli, M. P., Hodder, P., et al. Reversible inhibitor of p97, dbeq, impairs both ubiquitin-dependent and autophagic protein clearance pathways Proceedings of the National Academy of Sciences of the United States of America  2011 108:4834-4839  DOI:10.1073/pnas.1015312108  PMID:21383145  PMCID:PMC3064330
    • Urbano, M., Guerrero, M., Velaparthi, S., Crisp, M., Chase, P., Hodder, P., Schaeffer, M. T., Brown, S., Rosen, H., Roberts, E. Discovery, synthesis and sar analysis of novel selective small molecule s1p(4)-r agonists based on a (2z,5z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-o ne chemotype Bioorganic & Medicinal Chemistry Letters  2011 21:6739-6745  DOI:10.1016/j.bmcl.2011.09.049  PMID:21982495  PMCID:PMC3209756
    • Rillahan, C. D., Brown, S. J., Register, A. C., Rosen, H., Paulson, J. C. High-throughput screening for inhibitors of sialyl- and fucosyltransferases Angewandte Chemie-International Edition  2011 50:12534-12537  DOI:10.1002/anie.201105065  PMID:22095645  PMCID:PMC3245354
    • Marsolais, D., Yagi, S., Kago, T., Leaf, N., Rosen, H. Modulation of chemokines and allergic airway inflammation by selective local sphingosine-1-phosphate receptor 1 agonism in lungs Molecular Pharmacology  2011 79:61-68  DOI:10.1124/mol.110.066811  PMID:20935081  PMCID:PMC3014274
    • Gianni, D., Taulet, N., Zhang, H., DerMardirossian, C., Kister, J., Martinez, L., Roush, W. R., Brown, S. J., Bokoch, G. M., Rosen, H. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells ACS Chemical Biology  2010 5:981-993  DOI:10.1021/cb100219n  PMID:20715845  PMCID:PMC2955773
    • Bachovchin, D. A., Wolfe, M. R., Masuda, K., Brown, S. J., Spicer, T. P., Fernandez-Vega, V., Chase, P., Hodder, P. S., Rosen, H., Cravatt, B. F. Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9) Bioorganic & Medicinal Chemistry Letters  2010 20:2254-2258  DOI:10.1016/j.bmcl.2010.02.011  PMID:20207142  PMCID:PMC2843764
    • Walsh, K. B., Marsolais, D., Welch, M. J., Rosen, H., Oldstone, M. B. A. Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection Virology  2010 397:260-269  DOI:10.1016/j.virol.2009.08.043  PMID:19962171  PMCID:PMC2821988
    • Knuckley, B., Jones, J. E., Bachovchin, D. A., Slack, J., Causey, C. P., Brown, S. J., Rosen, H., Cravatt, B. F., Thompson, P. R. A fluopol-ABPP HTS assay to identify PAD inhibitors Chemical Communications  2010 46:7175-7177  DOI:10.1039/c0cc02634d  PMID:20740228  PMCID:PMC2943038
    • Goldsmith, M., Avni, D., Levy-Rimler, G., Mashiach, R., Ernst, O., Levi, M., Webb, B., Meijler, M. M., Gray, N. S., Rosen, H., Zor, T. A ceramide-1-phosphate analogue, pcera-1, simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages Immunology  2009 127:103-115  DOI:10.1111/j.1365-2567.2008.02928.x  PMID:18793216  PMCID:PMC2678186
    • Marsolais, D., Rosen, H. Chemical modulators of sphingosine-1-phosphate receptors as barrier-oriented therapeutic molecules Nature Reviews Drug Discovery  2009 8:297-307  DOI:10.1038/nrd2356  PMID:19300460  PMCID:PMC4455967
    • Fazilleau, N., McHeyzer-Williams, L. J., Rosen, H., McHeyzer-Williams, M. G. The function of follicular helper t cells is regulated by the strength of t cell antigen receptor binding Nature Immunology  2009 10:375-384  DOI:10.1038/ni.1704  PMID:19252493  PMCID:PMC2712297
    • Avni, D., Goldsmith, M., Ernst, O., Mashiach, R., Tuntland, T., Meijler, M. M., Gray, N. S., Rosen, H., Zor, T. Modulation of tnf alpha, il-10 and il-12p40 levels by a ceramide-1-phosphate analog, pcera-1, in vivo and ex vivo in primary macrophages Immunology Letters  2009 123:1-8  DOI:10.1016/j.imlet.2008.12.011  PMID:19185589
    • Don, A. S., Rosen, H. A lipid binding domain in sphingosine kinase 2 Biochemical and Biophysical Research Communications  2009 380:87-92  DOI:10.1016/j.bbrc.2009.01.075  PMID:19168031  PMCID:PMC2657340
    • Marsolais, D., Hahm, B., Walsh, K. B., Edelmann, K. H., McGavern, D., Hatta, Y., Kawaoka, Y., Rosen, H., Oldstone, M. B. A. A critical role for the sphingosine analog aal-r in dampening the cytokine response during influenza virus infection Proceedings of the National Academy of Sciences of the United States of America  2009 106:1560-1565  DOI:10.1073/pnas.0812689106  PMID:19164548  PMCID:PMC2635800
    • Nakai, R., Salisbury, C. M., Rosen, H., Cravatt, B. F. Ranking the selectivity of pubchem screening hits by activity-based protein profiling: MMP13 as a case study Bioorganic & Medicinal Chemistry  2009 17:1101-1108  DOI:10.1016/j.bmc.2008.03.018  PMID:18364257  PMCID:PMC2661618
    • Cahalan, S., Rosen, H. S1P1 signaling just keeps going and going and going Nature Chemical Biology  2009 5:377-378  DOI:10.1038/nchembio0609-377  PMID:19448604
    • Brown, S. J., Rosen, H., Cravatt, B. F. Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes Nature Biotechnology  2009 27:387-394  DOI:10.1038/nbt.1531  PMID:19329999  PMCID:PMC2709489
    • Gonzalez-Cabrera, P. J., Jo, E., Sanna, M. G., Brown, S., Leaf, N., Marsolais, D., Schaeffer, M. T., Chapman, J., Cameron, M., Guerrero, M., Roberts, E., Rosen, H. Full pharmacological efficacy of a novel S1P1 agonist that does not require S1P-like headgroup interactions Molecular Pharmacology  2008 74:1308-1318  DOI:10.1124/mol.108.049783  PMID:18708635  PMCID:PMC2575047
    • Schurer, S. C., Brown, S. J., Gonzalez-Cabrera, P. J., Schaeffer, M. T., Chapman, J., Jo, E., Chase, P., Spicer, T., Hodder, P., Rosen, H. Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening ACS Chemical Biology  2008 3:486-498  DOI:10.1021/cb800051m  PMID:18590333  PMCID:PMC2597349
    • Rosen, H., Gonzalez-Cabrera, P., Marsolais, D., Cahalan, S., Don, A. S., Sanna, M. G. Modulating tone: The overture of s1p receptor immunotherapeutics Immunological Reviews  2008 223:221-235  DOI:10.1111/j.1600-065X.2008.00645.x  PMID:18613839
    • Don, A. S., Rosen, H. A fluorescent plate reader assay for ceramide kinase Analytical Biochemistry  2008 375:265-271  DOI:10.1016/j.ab.2007.12.024  PMID:18206978  PMCID:PMC2516974
    • Niessen, F., Schaffner, F., Furlan-Freguia, C., Pawlinski, R., Bhattacharjee, G., Chun, J., Derian, C. K., Andrade-Gordon, P., Rosen, H., Ruf, W. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation Nature  2008 452:654-658  DOI:10.1038/nature06663  PMID:18305483
    • Marsolais, D., Hahm, B., Edelmann, K. H., Walsh, K. B., Guerrero, M., Hatta, Y., Kawaoka, Y., Roberts, E., Oldstone, M. B. A., Rosen, H. Local not systemic modulation of dendritic cell s1p receptors in lung blunts virus-specific immune responses to influenza Molecular Pharmacology  2008 74:896-903  DOI:10.1124/mol.108.048769  PMID:18577684  PMCID:PMC2574812
    • Tsukada, Y. T., Sanna, M. G., Rosen, H., Gottlieb, R. A. S1p1-selective agonist sew2871 exacerbates reperfusion arrhythmias Journal of Cardiovascular Pharmacology  2007 50:660-669  PMID:18091583
    • Lee, H. K., Brown, S. J., Rosen, H., Tobias, P. S. Application of beta-lactamase enzyme complementation to the high-throughput screening of toll-like receptor signaling inhibitors Molecular Pharmacology  2007 72:868-875  DOI:10.1124/mol.107.038349  PMID:17615244
    • Don, A. S., Martinez-Lamenca, C., Webb, W. R., Proia, R. L., Roberts, E., Rosen, H. Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues Journal of Biological Chemistry  2007 282:15833-15842  DOI:10.1074/jbc.M609124200  PMID:17400555
    • Gonzalez-Cabrera, P. J., Hla, T., Rosen, H. Mapping pathways downstream of sphingosine 1-phosphate subtype 1 by differential chemical perturbation and proteomics Journal of Biological Chemistry  2007 282:7254-7264  DOI:10.1074/jbc.M610581200  PMID:17218309
    • Rosen, H., Sanna, M. G., Cahalan, S. M., Gonzalez-Cabrera, P. J. Tipping the gatekeeper: S1p regulation of endothelial barrier function Trends in Immunology  2007 28:102-107  DOI:10.1016/j.it.2007.01.007  PMID:17276731
    • Sanna, M. G., Wang, S. K., Gonzalez-Cabrera, P. J., Don, A., Marsolais, D., Matheu, M. P., Wei, S. H., Parker, I., Jo, E. J., Cheng, W. C., Cahalan, M. D., Wong, C. H., et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P(1) antagonist in vivo Nature Chemical Biology  2006 2:434-441  DOI:10.1038/nchembio804  PMID:16829954
    • Alfonso, C., McHeyzer-Williams, M. G., Rosen, H. Cd69 down-modulation and inhibition of thymic egress by short- and long-term selective chemical agonism of sphingosine 1-phosphate receptors European Journal of Immunology  2006 36:149-159  DOI:10.1002/eji.200535127  PMID:16342326
    • Chun, J., Rosen, H. Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases Current Pharmaceutical Design  2006 12:161-171  DOI:10.2174/138161206775193109  PMID:16454733
    • Wei, S. H., Rosen, H., Matheu, M. P., Sanna, M. G., Wang, S. K., Jo, E. J., Wong, C. H., Parker, I., Cahalan, M. D. Sphingosine 1-phosphate type 1 receptor agonism inhibits transendothelial migration of medullary t cells to lymphatic sinuses Nature Immunology  2005 6:1228-1235  DOI:10.1038/ni1269  PMID:16273098
    • Li, Z., Chen, W. R., Hale, J. J., Lynch, C. L., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M. J., Milligan, J. A., Shei, G. J., Chrebet, G., Parent, S. A., et al. Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (s1p(1)) receptor agonists with exceptional selectivity against s1p(2) and s1p(3) Journal of Medicinal Chemistry  2005 48:6169-6173  DOI:10.1021/jm0503244  PMID:16190743
    • Rosen, H. Chemical approaches to the lysophospholipid receptors Prostaglandins & Other Lipid Mediators  2005 77:179-184  DOI:10.1016/j.prostaglandins.2004.09.011  PMID:16099402
    • Martinez, X., Kreuwel, H. T. C., Redmond, W. L., Trenney, R., Hunter, K., Rosen, H., Sarvetnick, N., Wicker, L. S., Sherman, L. A. CD8+ T cell tolerance in nonobese diabetic mice is restored by insulin-dependent diabetes resistance alleles Journal of Immunology  2005 175:1677-1685  PMID:16034108
    • Rosen, H., Goetzl, E. J. Sphingosine 1-phosphate and its receptors: An autocrine and paracrine network Nature Reviews Immunology  2005 5:560-570  DOI:10.1038/nri1650  PMID:15999095
    • Jo, E. J., Sanna, G., Gonzalez-Cabrera, P. J., Thangada, S., Tigyi, G., Osborne, D. A., Hla, T., Parrill, A. L., Rosen, H. S1p(1)-selective in vivo-active agonists from high-throughput screening: Off-the-shelf chemical probes of receptor interactions, signaling, and fate Chemistry & Biology  2005 12:703-715  DOI:10.1016/j.chembiol.2005.04.019  PMID:15975516
    • Gong, Q., Ou, Q. L., Ye, S. M., Lee, W. P., Cornelius, J., Diehl, L., Lin, W. Y., Hu, Z. L., Lu, Y. M., Chen, Y. M., Wu, Y., Meng, Y. G., et al. Importance of cellular microenvironment and circulatory dynamics in b cell immunotherapy Journal of Immunology  2005 174:817-826  PMID:15634903
    • Hale, J. J., Lynch, C. L., Neway, W., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M. J., Milligan, J. A., Shei, G. J., Parent, S. A., Chrebet, G., Bergstrom, J., et al. A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists Journal of Medicinal Chemistry  2004 47:6662-6665  DOI:10.1021/jm0492507  PMID:15615513
    • Goetzl, E. J., Rosen, H. Regulation of immunity by lysosphingolipids and their g protein - coupled receptors Journal of Clinical Investigation  2004 114:1531-1537  DOI:10.1172/jci200423704  PMID:15578083
    • Yan, L., Hale, J. J., Lynch, C. L., Budhu, R., Gentry, A., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M. J., Milligan, J. A., Shei, G. J., Chrebet, G., et al. Design and synthesis of conformationally constrained 3-(n-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (s1p) receptors Bioorganic & Medicinal Chemistry Letters  2004 14:4861-4866  DOI:10.1016/j.bmcl.2004.07.049  PMID:15341940
    • Hale, J. J., Yan, L., Neway, W. E., Hajdu, R., Bergstrom, J. D., Milligan, J. A., Shei, G. J., Chrebet, G. L., Thornton, R. A., Card, D., Rosenbach, M., Rosen, H., et al. Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent fty720 Bioorganic & Medicinal Chemistry  2004 12:4803-4807  DOI:10.1016/j.bmc.2004.07.020  PMID:15336258
    • Hale, J. J., Doherty, G., Toth, L., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M., Milligan, J., Shei, G. J., Chrebet, G., Bergstrom, J., Card, D., et al. Selecting against s1p(3) enhances the acute cardiovascular tolerability of 3-(n-benzyl)aminopropylphosphonic acid s1p receptor agonists Bioorganic & Medicinal Chemistry Letters  2004 14:3501-3505  DOI:10.1016/j.bmcl.2004.04.070  PMID:15177461
    • Hale, J. J., Doherty, G., Toth, L., Li, Z., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M., Milligan, J., Shei, G. J., Chrebet, G., Bergstrom, J., et al. The discovery of 3-(n-alkyl)aminopropylphosphonic acids as potent s1p receptor agonists Bioorganic & Medicinal Chemistry Letters  2004 14:3495-3499  DOI:10.1016/j.bmcl.2004.04.069  PMID:15177460
    • Hale, J. J., Neway, W., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M., Milligan, J., Shei, G. J., Chrebet, G., Bergstrom, J., Card, D., Koo, G. C., et al. Potent s1p receptor agonists replicate the pharmacologic actions of the novel immune modulator fty720 Bioorganic & Medicinal Chemistry Letters  2004 14:3351-3355  DOI:10.1016/j.bmcl.2004.02.106  PMID:15149705
    • Forrest, M., Sun, S. Y., Hajdu, R., Bergstrom, J., Card, D., Doherty, G., Hale, J., Keohane, C., Meyers, C., Milligan, J., Mills, S., Nomura, N., et al. Immune cell regulation and cardiovascular effects of sphingosine 1-phosphate receptor agonists in rodents are mediated via distinct receptor subtypes Journal of Pharmacology and Experimental Therapeutics  2004 309:758-768  DOI:10.1124/jpet.103.062828  PMID:14747617
    • Sanna, M. G., Liao, J. Y., Jo, E. J., Alfonso, C., Ahn, M. Y., Peterson, M. S., Webb, B., Lefebvre, S., Chun, J., Gray, N., Rosen, H. Sphingosine 1-phosphate (S1P) receptor subtypes S1P1 and S1P3, respectively, regulate lymphocyte recirculation and heart rate Journal of Biological Chemistry  2004 279:13839-13848  DOI:10.1074/jbc.M311743200  PMID:14732717
    • Rosen, H., Sanna, G., Alfonso, C. Egress: A receptor-regulated step in lymphocyte trafficking Immunological Reviews  2003 195:160-177  DOI:10.1034/j.1600-065X.2003.00068.x  PMID:12969317
    • Rosen, H., Alfonso, C., Surh, C. D., McHeyzer-Williams, M. G. Rapid induction of medullary thymocyte phenotypic maturation and egress inhibition by nanomolar sphingosine 1-phosphate receptor agonist Proceedings of the National Academy of Sciences of the United States of America  2003 100:10907-10912  DOI:10.1073/pnas.1832725100  PMID:12954982  PMCID:PMC196901
    • Rosen, H., Liao, J. Y. Sphingosine 1-phosphate pathway therapeutics: A lipid ligand-receptor paradigm Current Opinion in Chemical Biology  2003 7:461-468  DOI:10.1016/s1367-5931(03)00085-1  PMID:12941420
    • Ferrer, M., Kolodin, G. D., Zuck, P., Peltier, R., Berry, K., Mandala, S. M., Rosen, H., Ota, H., Ozaki, S., Inglese, J., Strulovici, B. A fully automated s-35 gtp gamma s scintillation proximity assay for the high-throughput screening of g(i)-linked g protein-coupled receptors Assay and Drug Development Technologies  2003 1:261-273  DOI:10.1089/15406580360545071  PMID:15090191
    • Xie, J. H., Nomura, N., Koprak, S. L., Quackenbush, E. J., Forrest, M. J., Rosen, H. Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated cd4(+) t cells Journal of Immunology  2003 170:3662-3670  PMID:12646631
    • Bowman, J. C., Hicks, P. S., Kurtz, M. B., Rosen, H., Schmatz, D. M., Liberator, P. A., Douglas, C. M. The antifungal echinocandin caspofungin acetate kills growing cells of aspergillus fumigatus in vitro Antimicrobial Agents and Chemotherapy  2002 46:3001-3012  DOI:10.1128/aac.46.9.3001-3012.2002  PMID:12183260
    • Parent, S. A., Zhang, T., Chrebet, G., Clemas, J. A., Figueroa, D. J., Ky, B., Blevins, R. A., Austin, C. P., Rosen, H. Molecular characterization of the murine signr1 gene encoding a c-type lectin homologous to human dc-sign and dc-signr Gene  2002 293:33-46  DOI:10.1016/s0378-1119(02)00722-9  PMID:12137941
    • Mandala, S., Hajdu, R., Bergstrom, J., Quackenbush, E., Xie, J., Milligan, J., Thornton, R., Shei, G. J., Card, D., Keohane, C., Rosenbach, M., Hale, J., et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists Science  2002 296:346-349  DOI:10.1126/science.1070238  PMID:11923495
    • Abruzzo, G. K., Gill, C. J., Flattery, A. M., Kong, L., Leighton, C., Smith, J. G., Pikounis, V. B., Bartizal, K., Rosen, H. Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice Antimicrobial Agents and Chemotherapy  2000 44:2310-2318  DOI:10.1128/aac.44.9.2310-2318.2000  PMID:10952573
    • Kohler, J., Dorso, K. L., Young, K., Hammond, G. G., Rosen, H., Kropp, H., Silver, L. L. In vitro activities of the potent, broad-spectrum carbapenem mk-0826 (l-749,345) against broad-spectrum beta-lactamase- and extended-spectrum p-lactamase-producing klebsiella pneumoniae and escherichia coli clinical isolates Antimicrobial Agents and Chemotherapy  1999 43:1170-1176  PMID:10223931  PMCID:PMC89128
    • Rosen, H., Hajdu, R., Silver, L., Kropp, H., Dorso, K., Kohler, J., Sundelof, J. G., Huber, J., Hammond, G. G., Jackson, J. J., Gill, C. J., Thompson, R., et al. Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic Science  1999 283:703-706  DOI:10.1126/science.283.5402.703  PMID:9924033
    • Gill, C. J., Jackson, J. J., Gerckens, L. S., Pelak, B. A., Thompson, R. K., Sundelof, J. G., Kropp, H., Rosen, H. In vivo activity and pharmacokinetic evaluation of a novel long-acting carbapenem antibiotic, mk-826 (l-749,345) Antimicrobial Agents and Chemotherapy  1998 42:1996-2001  PMID:9687396  PMCID:PMC105722
    • Abruzzo, G. K., Flattery, A. M., Gill, C. J., Kong, L., Smith, J. G., Pikounis, V. B., Balkovec, J. M., Bouffard, A. F., Dropinski, J. F., Rosen, H., Kropp, H., Bartizal, K. Evaluation of the echinocandin antifungal mk-0991 (l-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis Antimicrobial Agents and Chemotherapy  1997 41:2333-2338  PMID:9371329  PMCID:PMC164124
    • Beck, L. A., Dalke, S., Leiferman, K. M., Bickel, C. A., Hamilton, R., Rosen, H., Bochner, B. S., Schleimer, R. P. Cutaneous injection of rantes causes eosinophil recruitment - comparison of nonallergic and allergic human subjects Journal of Immunology  1997 159:2962-2972  PMID:9300720
    • Sundelof, J. G., Hajdu, R., Gill, C. J., Thompson, R., Rosen, H., Kropp, H. Pharmacokinetics of l-749,345, a long-acting carbapenem antibiotic, in primates Antimicrobial Agents and Chemotherapy  1997 41:1743-1748  PMID:9257753  PMCID:PMC163997
    • Gordon, E. J., Myers, K. J., Dougherty, J. P., Rosen, H., Ron, Y. Both anti-cd11a (lfa-i) and anti-cd11b (mac-1) therapy delay the onset and diminish the severity of experimental autoimmune encephalomyelitis Journal of Neuroimmunology  1995 62:153-160  DOI:10.1016/0165-5728(95)00120-2  PMID:7499503
    • Zheng, H., Fletcher, D., Kozak, W., Jiang, M. H., Hofmann, K. J., Conn, C. A., Soszynski, D., Grabiec, C., Trumbauer, M. E., Shaw, A., Kostura, M. J., Stevens, K., et al. Resistance to fever induction and impaired acute-phase response in interleukin-1-beta-deficient mice Immunity  1995 3:9-19  DOI:10.1016/1074-7613(95)90154-x  PMID:7621081
    • Konteatis, Z. D., Siciliano, S. J., Vanriper, G., Molineaux, C. J., Pandya, S., Fischer, P., Rosen, H., Mumford, R. A., Springer, M. S. Development of c5a receptor antagonists - differential loss of functional-responses Journal of Immunology  1994 153:4200-4205  PMID:7930622
    • Demartino, J. A., Vanriper, G., Siciliano, S. J., Molineaux, C. J., Konteatis, Z. D., Rosen, H., Springer, M. S. The amino-terminus of the human c5a receptor is required for high-affinity c5a binding and for receptor activation by c5a but not c5a analogs Journal of Biological Chemistry  1994 269:14446-14450  PMID:8182049
    • Vanriper, G., Nicholson, D. W., Scheid, M. P., Fischer, P. A., Springer, M. S., Rosen, H. Induction, characterization, and functional coupling of the high affinity chemokine receptor for RANTES and macrophage inflammatory protein-1 alpha upon differentiation of an eosinophilic HL-60 cell line Journal of Immunology  1994 152:4055-4061  PMID:7511665
    • Siciliano, S. J., Rollins, T. E., Demartino, J., Konteatis, Z., Malkowitz, L., Vanriper, G., Bondy, S., Rosen, H., Springer, M. S. Two-site binding of C5a by its receptor: an alternative binding paradigm for G protein-coupled receptors Proceedings of the National Academy of Sciences of the United States of America  1994 91:1214-1218  DOI:10.1073/pnas.91.4.1214  PMID:8108389  PMCID:PMC43127
    • Koo, G. C., Rosen, H., Sirotina, A., Ma, X. D., Shultz, L. D. Anti-cd11b antibody prevents immunopathologic changes in viable moth-eaten bone-marrow chimeric mice Journal of Immunology  1993 151:6733-6741  PMID:8258688
    • Meurer, R., Vanriper, G., Feeney, W., Cunningham, P., Hora, D., Springer, M. S., Macintyre, D. E., Rosen, H. Formation of eosinophilic and monocytic intradermal inflammatory sites in the dog by injection of human rantes but not human monocyte chemoattractant protein-1, human macrophage inflammatory protein 1-alpha, or human interleukin-8 Journal of Experimental Medicine  1993 178:1913-1921  DOI:10.1084/jem.178.6.1913  PMID:7504053
    • Cervia, J. S., Rosen, H., Murray, H. W. Effector role of blood monocytes in experimental visceral leishmaniasis Infection and Immunity  1993 61:1330-1333  PMID:8454335  PMCID:PMC281366
    • Vanriper, G., Siciliano, S., Fischer, P. A., Meurer, R., Springer, M. S., Rosen, H. Characterization and species distribution of high-affinity gtp-coupled receptors for human rantes and monocyte chemoattractant protein-1 Journal of Experimental Medicine  1993 177:851-856  DOI:10.1084/jem.177.3.851  PMID:7679712
    • Whitcup, S. M., Debarge, L. R., Rosen, H., Nussenblatt, R. B., Chan, C. C. Monoclonal-antibody against cd11b cd18 inhibits endotoxin-induced uveitis Investigative Ophthalmology & Visual Science  1993 34:673-681  PMID:8095493
    • Robinson, M. K., Andrew, D., Rosen, H., Brown, D., Ortlepp, S., Stephens, P., Butcher, E. C. Antibody against the leu-cam beta-chain (cd18) promotes both lfa-1-dependent and cr3-dependent adhesion events Journal of Immunology  1992 148:1080-1085  PMID:1371129
    • Grau, G. E., Pointaire, P., Piguet, P. F., Vesin, C., Rosen, H., Stamenkovic, I., Takei, F., Vassalli, P. Late administration of monoclonal-antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria European Journal of Immunology  1991 21:2265-2267  DOI:10.1002/eji.1830210939  PMID:1679717
    • Blankenstein, T., Qin, Z. H., Uberla, K., Muller, W., Rosen, H., Volk, H. D., Diamantstein, T. Tumor suppression after tumor-cell targeted tumor-necrosis-factor-alpha gene-transfer Journal of Experimental Medicine  1991 173:1047-1052  DOI:10.1084/jem.173.5.1047  PMID:2022919
    • Hurst, J. K., Loehr, T. M., Curnutte, J. T., Rosen, H. Resonance raman and electron-paramagnetic resonance structural investigations of neutrophil cytochrome-b558 Journal of Biological Chemistry  1991 266:1627-1634  PMID:1846361
    • Heyworth, P. G., Curnutte, J. T., Nauseef, W. M., Volpp, B. D., Pearson, D. W., Rosen, H., Clark, R. A. Neutrophil nicotinamide adenine-dinucleotide phosphate oxidase assembly - translocation of p47-phox and p67-phox requires interaction between p47-phox and cytochrome-b558 Journal of Clinical Investigation  1991 87:352-356  DOI:10.1172/jci114993  PMID:1985107
    • Hutchings, P., Rosen, H., Oreilly, L., Simpson, E., Gordon, S., Cooke, A. Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages Nature  1990 348:639-641  DOI:10.1038/348639a0  PMID:2250718
    • Rosen, H. Role of CR3 in induced myelomonocytic recruitment: insights from in vivo monoclonal antibody studies in the mouse Journal of Leukocyte Biology  1990 48:465-469  PMID:2230596
    • Rosen, H., Gordon, S. The role of the type-3 complement receptor in the induced recruitment of myelomonocytic cells to inflammatory sites in the mouse American Journal of Respiratory Cell and Molecular Biology  1990 3:3-10  PMID:2141991
    • Rosen, H., Gordon, S. Adoptive transfer of fluorescence-labeled cells shows that resident peritoneal-macrophages are able to migrate into specialized lymphoid organs and inflammatory sites in the mouse European Journal of Immunology  1990 20:1251-1258  DOI:10.1002/eji.1830200609  PMID:2369918
    • Rosen, H., Law, S. K. A. The leukocyte cell-surface receptor(s) for the ic3b product of complement Current Topics in Microbiology and Immunology  1990 153:99-122  PMID:2137074
    • Dinauer, M. C., Curnutte, J. T., Rosen, H., Orkin, S. H. A missense mutation in the neutrophil cytochrome-b heavy-chain in cytochrome-positive x-linked chronic granulomatous-disease Journal of Clinical Investigation  1989 84:2012-2016  DOI:10.1172/jci114393  PMID:2556453
    • Rosen, H., Gordon, S., North, R. J. Exacerbation of murine listeriosis by a monoclonal-antibody specific for the type-3 complement receptor of myelomonocytic cells - absence of monocytes at infective foci allows listeria to multiply in nonphagocytic cells Journal of Experimental Medicine  1989 170:27-37  DOI:10.1084/jem.170.1.27  PMID:2501445
    • Rosen, H., Gordon, S. Current status review - adhesion molecules and myelomonocytic cell-endothelial interactions British Journal of Experimental Pathology  1989 70:385-394  PMID:2669925  PMCID:PMC2040576
    • Lunn, E. R., Perry, V. H., Brown, M. C., Rosen, H., Gordon, S. Absence of wallerian degeneration does not hinder regeneration in peripheral-nerve European Journal of Neuroscience  1989 1:27-33  DOI:10.1111/j.1460-9568.1989.tb00771.x  PMID:12106171
    • Rosen, H., Milon, G., Gordon, S. Antibody to the murine type 3 complement receptor inhibits T lymphocyte-dependent recruitment of myelomonocytic cells in vivo Journal of Experimental Medicine  1989 169:535-548  DOI:10.1084/jem.169.2.535  PMID:2521356  PMCID:PMC2189217
    • Cooper, A., Rosen, H., Blackwell, J. M. Monoclonal-antibodies that recognize distinct epitopes of the macrophage type 3 complement receptor differ in their ability to inhibit binding of leishmania promastigotes harvested at different phases of their growth-cycle Immunology  1988 65:511-514  PMID:3065216  PMCID:PMC1385558
    • Okamura, N., Malawista, S. E., Roberts, R. L., Rosen, H., Ochs, H. D., Babior, B. M., Curnutte, J. T. Phosphorylation of the oxidase-related k-48 phosphoprotein family in the unusual autosomal cytochrome-negative and x-linked cytochrome-positive types of chronic granulomatous-disease Blood  1988 72:811-816  PMID:3401601
    • Rosen, H., Gordon, S. Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo Journal of Experimental Medicine  1987 166:1685-1701  DOI:10.1084/jem.166.6.1685  PMID:2445894  PMCID:PMC2188801
    • Rosen, H., Gordon, S. Surface events in polymorphonuclear leukocyte activation - insights from a hydrophobic membrane antigen that triggers the respiratory burst Journal of Cell Science  1987 88:591-601  PMID:2459144
    • Berton, G., Rosen, H., Ezekowitz, R. A. B., Bellavite, P., Serra, M. C., Rossi, F., Gordon, S. Monoclonal-antibodies to a particulate superoxide-forming system stimulate a respiratory burst in intact guinea-pig neutrophils Proceedings of the National Academy of Sciences of the United States of America  1986 83:4002-4006  DOI:10.1073/pnas.83.11.4002  PMID:3012541
    • Millar, R. P., Rosen, H., Badminton, M., Pasqualini, C., Kerdelhue, B. Luteinizing-hormone-releasing hormone (lh-rh) binding to purified rat pituitary nuclei FEBS Letters  1983 153:382-386  DOI:10.1016/0014-5793(83)80648-6  PMID:6311621
  • report

    • Hulce, J. J., Joslyn, C., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. An in vivo active carbamate-based dual inhibitor of lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:25506974
    • Zuhl, A. M., Mohr, J. T., Speers, A. E., Bachovchin, D. A., Berlin, J. M., Spicer, T., Fernandez-Vega, V., Brown, S. J., Ferguson, J., Fu, G. C., Cravatt, B. F., Hodder, P., et al. Probe development efforts to identify novel inhibitors of ABHD10 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762952
    • Kumar, N., Nuhant, P., Solt, L. A., Conkright, J. J., Wang, Y., Istrate, M. A., Busby, S. A., Ruben, D. G. O., Burris, T. P., Cameron, M., Mercer, B. A., Hodder, P., et al. Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORalpha) 2010
    • Kumar, N., Kamenecka, T., Lyda, B., Khan, P., Chang, M. R., Garcia-Ordonez, R. D., Cameron, M., Ferguson, J., Mercer, B. A., Hodder, P., Rosen, H., Griffin, P. R. Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Gamma (RORgamma) 2010
    • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:24624468
    • Adibekian, A., Martin, B. R., Chang, J. W., Hsu, K. L., Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., et al. Characterization of a selective, reversible inhibitor of lysophospholipase 1 (LYPLA1) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:24624465
    • Schoenen, F. J., Whipple, D., Baillargeon, P., Brown, C. L., Chase, P., Ferguson, J., Fernandez-Vega, V., Hodder, P., Mathew, R., Neuenswander, B., Porubsky, P., Rogers, S., et al. Inhibitors of the Plasmodium falciparum M17 leucine aminopeptidase Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:25506973
    • Schoenen, F. J., Weiner, W. S., Baillargeon, P., Brown, C. L., Chase, P., Ferguson, J., Fernandez-Vega, V., Ghosh, P., Hodder, P., Krise, J. P., Matharu, D. S., Neuenswander, B., et al. Inhibitors of the Plasmodium falciparum M18 aspartyl aminopeptidase Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:24479194
    • Nagano, J. M. G., Hsu, K. L., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Bahnson, B. J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658952
    • Dreyton, C. J., Jones, J. E., Knuckley, B. A., Subramanian, V., Anderson, E. D., Brown, S. J., Fernandez-Vega, V., Eberhart, C., Spicer, T., Zuhl, A. M., Ferguson, J., Speers, A. E., et al. Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23833800
    • Adibekian, A., Martin, B. R., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658947
    • Adibekian, A., Hsu, K. L., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658953
    • Hsu, K. L., Tsuboi, K., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-beta) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658950
    • Adibekian, A., Hsu, K. L., Speers, A. E., Monillas, E. S., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Bahnson, B. J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658960
    • Tsuboi, K., Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of an inhibitor for glutathione S-tranferase omega 1 (GSTO1) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:22834034
    • Hsu, K. L., Tsuboi, K., Speers, A. E., Brown, S. J., Spicer, T., Fernandez-Vega, V., Ferguson, J., Cravatt, B. F., Hodder, P., Rosen, H. Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762934
    • Guerrero, M., Poddutoori, R., Pinacho-Crisostomo, F., Schaeffer, M. T., Brown, S. J., Spicer, T., Chase, P., Ferguson, J., Roberts, E., Sanna, G., Hodder, P., Rosen, H. Probe development efforts for an allosteric agonist of the sphingosine 1-phosphate receptor 3 (S1P3) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23658964
    • Bachovchin, D. A., Speers, A. E., Brown, S. J., Spicer, T. P., Fernandez, Vega, Ferguson, J., Mohr, J. T., Murphy, J., Fu, G. C., Cravatt, B. F., Hodder, P. S., Rosen, H. Probe development efforts to identify novel inhibitors of protein phosphatase methylesterase-1 (PME-1) Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:22834039
    • Bachovchin, D. A., Speers, A. E., Zuhl, A. M., Brown, S. J., Cravatt, B. F., Fernandez, Vega, Spicer, T., Mercer, B. A., Ferguson, J., Hodder, P., Rosen, H. R. Probe report for PME-1 inhibitors Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21433379
    • Brown, S. J., Bachovchin, D. A., Cravatt, B. F., Fernandez-Vega, V., Spicer, T., Mercer, B. A., Hodder, P., Rosen, H. R. Probe report for RBBP9 inhibitors - Probe 1 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21433353
    • Bachovchin, D. A., Speers, A. E., Brown, S. J., Cravatt, B. F., Spicer, T., Mercer, B. A., Ferguson, J., Hodder, P., Rosen, H. R. Probe report for RBBP9 inhibitors - Probe 2 Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:21433382
  • thesis

    • Rosen, H. Biochemical and cellular studies of a polymorphonuclear leukocyte surface antigen implicated in the triggering of the respiratory burst 1986

editor of

  • chapter

    • Chemical and genetic tools to explore S1P biology Sphingosine-1-phosphate signaling in immunology and infectious diseases. 55-83. 2014
  • edited book

    • Oldstone, M. B. A., Rosen, H., eds. Sphingosine-1-phosphate signaling in immunology and infectious diseases Current Topics in Microbiology and Immunology. 2014

featured in

  • Bi-Coastal Collaboration Uncovers Novel Activators of Key Cell Receptors  News Release
  • NIH Awards $10.4 Million to Scripps Research in La Jolla and Palm Beach County  Newsletter
  • Of Translation and Basic Research: An Interview with Hugh Rosen  Newsletter
  • Scripps Research Forms New Department of Chemical Physiology  Newsletter
  • Scripps Research Scientists Win $65 Million in New Grants  Newsletter
  • Team Discovers Treatable Mechanism Responsible for Often Deadly Response to Flu  Newsletter
  • Wet Lungs or Dry? Scripps Research Scientists Discover New Key to Pulmonary Edema in Respiratory Distress Syndrome  News Release
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Research

research overview

  • Chemical and biological approaches to the molecular mechanisms regulating lymphocyte trafficking

    The maintenance of effective host defense depends upon the recirculation of lymphocytes from blood to lymph nodes and returning to blood via lymph. My lab recently described a new molecular mechanism regulating egress of lymphocytes from lymph nodes into lymph and thus blood using reverse pharmacology. A potent compound was identified (FTY720) that induced the disappearance of lymphocytes from peripheral blood. It was phosphorylated to a biologically active and potent molecule that allowed the identification of a molecular target. The mechanism was found to be the activation of a family of G-protein-coupled edg receptors for sphingosine 1-phosphate. We are able to use highly potent picomolar synthetic compounds that activate these receptors at alter lymphocyte trafficking and produce immunosuppression. This mechanism of immunosuppression is of significant interest as a potential novel approach to transplantation rejection and autoimmune diseases including multiple sclerosis. The focus of the laboratory is on using chemical probes of receptor function to elucidate the molecular basis of the control of lymphocyte trafficking, at the level of lymphocytes and endothelial cells, and in the specific tissue microenvironments in lymphoid organs.

    Our approaches involve identifying receptors implicated in lymphocyte trafficking, developing chemical agonists and antagonists of receptor function, the evaluation of receptor contribution to cell function in vivo and the identification of transductional and physical changes regulating lymphocyte trafficking in vitro and in intact lymphoid organs by biochemical and imaging methods including confocal scanning microscopy.

    These studies are defining fundamental mechanisms of receptors and ligands not previously known to regulate immune function, that may have broad clinical impact.
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Teaching

teaching activities

  • Molecular Medicine - MM238 Course Director

advisees

  • graduate advising relationship

    • Cahalan, Stuart Morgan, Ph.D.  candidate, 2005 - 2011
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Service

professional service activities

  • The American Association of Immunologists Member 2003 -
  • Biochemical Society Member and Editorial Advisor
  • Infectious Diseases Society of America Fellow
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Background

education and training

  • Ph.D. in Physiological Sciences, University of Oxford , Medical Sciences Division, with Dr. Siamon Gordon 1986
  • M.D. in Medicine, University of Cape Town 1982

awards and honors

  • Wellcome Senior Research Fellow in the Basic Biomedical Sciences, University of Oxford
  • Graduate Scholarship, Wolfson College, University of Oxford
  • Junior Research Fellow in Medicine and Biological Sciences, Jesus College, University of Oxford
  • Ochberg Scholarship, University of Cape Town
  • Royal Commission for the Exhibition of 1851 Science Research Scholarship held at the Sir William Dunn School of Pathology, University of Oxford
  • Allschwang Scholarship, University of Cape Town
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Contact

full name

  • Hugh Rosen

geographic location

  • Scripps California 

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