academic article

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• Cippitelli, A., Ayanwuyi, L. O., Barbier, E., Domi, E., Lerma-Cabrera, J. M., Carvajal, F., Scuppa, G., Li, H., Ubaldi, M., Heilig, M., Roberto, M., Ciccocioppo, R. Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats Psychopharmacology  2015 232:1083-1093  DOI:10.1007/s00213-014-3743-7  PMID:25260340  PMCID:PMC4339612
• Bajo, M., Herman, M. A., Varodayan, F. P., Oleata, C. S., Madamba, S. G., Harris, R. A., Blednov, Y. A., Roberto, M. Role of the IL-1 receptor antagonist in ethanol-induced regulation of GABAergic transmission in the central amygdala Brain Behavior and Immunity  2015 45:189-197  DOI:10.1016/j.bbi.2014.11.011  PMID:25479427  PMCID:PMC4405101
• Grieder, T. E., Herman, M. A., Contet, C., Tan, L. A., Vargas-Perez, H., Cohen, A., Chwalek, M., Maal-Bared, G., Freiling, J., Schlosburg, J. E., Clarke, L., Crawford, E., et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation Nature Neuroscience  2014 17:1751-1758  DOI:10.1038/nn.3872  PMID:25402857  PMCID:PMC4241147
• Ciccocioppo, R., Stopponi, S., Economidou, D., Kuriyama, M., Kinoshita, H., Heilig, M., Roberto, M., Weiss, F., Teshima, K. Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat Neuropsychopharmacology  2014 39:2601-2610  DOI:10.1038/npp.2014.113  PMID:24863033  PMCID:PMC4207340
• Kallupi, M., Varodayan, F. P., Oleata, C. S., Correia, D., Luu, G., Roberto, M. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats Neuropsychopharmacology  2014 39:1081-1092  DOI:10.1038/npp.2013.308  PMID:24169802  PMCID:PMC3957102
• Gilpin, N. W., Roberto, M., Koob, G. F., Schweitzer, P. Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala Neuropharmacology  2014 77:294-302  DOI:10.1016/j.neuropharm.2013.10.005  PMID:24157490  PMCID:PMC3873141
• Ciccocioppo, R., de Guglielmo, G., Hansson, A. C., Ubaldi, M., Kallupi, M., Cruz, M. T., Oleata, C. S., Heilig, M., Roberto, M. Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors Journal of Neuroscience  2014 34:363-372  DOI:10.1523/jneurosci.2400-13.2014  PMID:24403138  PMCID:PMC3870926
• Kallupi, M., Wee, S., Edwards, S., Whitfield, T. W., Oleata, C. S., Luu, G., Schmeichel, B. E., Koob, G. F., Roberto, M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction Biological Psychiatry  2013 74:520-528  DOI:10.1016/j.biopsych.2013.04.028  PMID:23751206  PMCID:PMC3773286
• Herman, M. A., Kallupi, M., Luu, G., Oleata, C. S., Heilig, M., Koob, G. F., Ciccocioppo, R., Roberto, M. Enhanced gabaergic transmission in the central nucleus of the amygdala of genetically selected marchigian sardinian rats: Alcohol and crf effects Neuropharmacology  2013 67:337-348  DOI:10.1016/j.neuropharm.2012.11.026  PMID:23220399  PMCID:PMC3562384
• Cui, C. H., Noronha, A., Morikawa, H., Alvarez, V. A., Stuber, G. D., Szumlinski, K. K., Kash, T. L., Roberto, M., Wilcox, M. V. New insights on neurobiological mechanisms underlying alcohol addiction Neuropharmacology  2013 67:223-232  DOI:10.1016/j.neuropharm.2012.09.022  PMID:23159531  PMCID:PMC3562413
• Herman, M. A., Contet, C., Justice, N. J., Vale, W., Roberto, M. Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice Journal of Neuroscience  2013 33:3284-3298  DOI:10.1523/jneurosci.2490-12.2013  PMID:23426657  PMCID:PMC3711798
• Cruz, M. T., Herman, M. A., Cote, D. M., Ryabinin, A. E., Roberto, M. Ghrelin increases gabaergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala Neuropsychopharmacology  2013 38:364-375  DOI:10.1038/npp.2012.190  PMID:22968812  PMCID:PMC3527109
• Ayanwuyi, L. O., Carvajal, F., Lerma-Cabrera, J. M., Domi, E., Bjork, K., Ubaldi, M., Heilig, M., Roberto, M., Ciccocioppo, R., Cippitelli, A. Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats Frontiers in Psychiatry  2013 4:23  DOI:10.3389/fpsyt.2013.00023  PMID:23630503  PMCID:PMC3624086
• Lovinger, D. M., Roberto, M. Synaptic effects induced by alcohol Current Topics in Behavioral Neurosciences  2013 13:31-86  DOI:10.1007/7854_2011_143  PMID:21786203  PMCID:PMC4791588
• Roberto, M., Gilpin, N. W., Siggins, G. R. The central amygdala and alcohol: Role of γ-aminobutyric acid, glutamate, and neuropeptides Cold Spring Harbor Perspectives in Medicine  2012 2:a012195  DOI:10.1101/cshperspect.a012195  PMID:23085848  PMCID:PMC3543070
• Cruz, M. T., Herman, M. A., Kallupi, M., Roberto, M. Nociceptin/orphanin fq blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure Biological Psychiatry  2012 71:666-676  DOI:10.1016/j.biopsych.2011.10.032  PMID:22153590  PMCID:PMC3838304
• Gilpin, N. W., Roberto, M. Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence Neuroscience and Biobehavioral Reviews  2012 36:873-888  DOI:10.1016/j.neubiorev.2011.11.002  PMID:22101113  PMCID:PMC3325612
• Bajo, M., Roberto, M., Madamba, S. G., Siggins, G. R. Neuroadaptation of gabaergic transmission in the central amygdala during chronic morphine treatment Addiction Biology  2011 16:551-564  DOI:10.1111/j.1369-1600.2010.00269.x  PMID:21182569  PMCID:PMC3117063
• Gilpin, N. W., Misra, K., Herman, M. A., Cruz, M. T., Koob, G. F., Roberto, M. Neuropeptide y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence Biological Psychiatry  2011 69:1091-1099  DOI:10.1016/j.biopsych.2011.02.004  PMID:21459365  PMCID:PMC3090491
• Cruz, M. T., Bajo, M., Maragnoli, M. E., Tabakoff, B., Siggins, G. R., Roberto, M. Type 7 adenylyl cyclase is involved in the ethanol and crf sensitivity of gabaergic synapses in mouse central amygdala Frontiers in Neuroscience  2011 4:207  DOI:10.3389/fnins.2010.00207  PMID:21258618  PMCID:PMC3024005
• Roberto, M., Cruz, M., Bajo, M., Siggins, G. R., Parsons, L. H., Schweitzer, P. The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala Neuropsychopharmacology  2010 35:1962-1972  DOI:10.1038/npp.2010.70  PMID:20463657  PMCID:PMC2904853
• Roberto, M., Cruz, M. T., Gilpin, N. W., Sabin, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., et al. Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence Biological Psychiatry  2010 67:831-839  DOI:10.1016/j.biopsych.2009.11.007  PMID:20060104  PMCID:PMC2883449
• Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., et al. CRF system recruitment mediates dark side of compulsive eating Proceedings of the National Academy of Sciences of the United States of America  2009 106:20016-20020  DOI:10.1073/pnas.0908789106  PMID:19901333  PMCID:PMC2785284
• Silberman, Y., Bajo, M., Chappell, A. M., Christian, D. T., Cruz, M., Diaz, M. R., Kash, T., Lack, A. K., Messing, R. O., Siggins, G. R., Winder, D., Roberto, M., et al. Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions Alcohol  2009 43:509-519  DOI:10.1016/j.alcohol.2009.01.002  PMID:19913194  PMCID:PMC2814297
• Witkiewitz, K., Holmes, A., Ray, L. A., Murphy, J. G., Richardson, H. N., Chen, Y. C., McDevitt-Murphy, M. E., Cruz, M. T., Roberto, M. Young investigator award symposium Alcohol  2009 43:499-508  DOI:10.1016/j.alcohol.2009.06.004  PMID:19913193
• Bajo, M., Roberto, M., Schweitzer, P. Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands Journal of Neuroscience Research  2009 87:766-775  DOI:10.1002/jnr.21889  PMID:18816788  PMCID:PMC3816768
• Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Roberto, M., Madamba, S. G., Siggins, G. R., Moore, S. D. Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: Lack of ethanol interactions Journal of Pharmacology and Experimental Therapeutics  2009 328:284-293  DOI:10.1124/jpet.108.140749  PMID:18854491  PMCID:PMC2685907
• Kenny, P. J., Chartoff, E., Roberto, M., Carlezon, W. A., Markou, A. Nmda receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: Role of the ventral tegmental area and central nucleus of the amygdala Neuropsychopharmacology  2009 34:266-281  DOI:10.1038/npp.2008.58  PMID:18418357  PMCID:PMC2654386
• Nie, Z. G., Zorrilla, E. P., Madamba, S. G., Rice, K. C., Roberto, M., Siggins, G. R. Presynaptic crf(1) receptors mediate the ethanol enhancement of gabaergic transmission in the mouse central amygdala Thescientificworldjournal  2009 9:68-85  DOI:10.1100/tsw.2009.1  PMID:19151899  PMCID:PMC3053445
• Bajo, M., Cruz, M. T., Siggins, G. R., Messing, R., Roberto, M. Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala Proceedings of the National Academy of Sciences of the United States of America  2008 105:8410-8415  DOI:10.1073/pnas.0802302105  PMID:18541912  PMCID:PMC2448850
• Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., Koob, G. F. Cellular and behavioral interactions of gabapentin with alcohol dependence Journal of Neuroscience  2008 28:5762-5771  DOI:10.1523/jneurosci.0575-08.2008  PMID:18509038  PMCID:PMC2493536
• Cruz, M. T., Bajo, M., Schweitzer, P., Roberto, M. Shared mechanisms of alcohol and other drugs Alcohol Research and Health  2008 31:137-147  PMID:23584815  PMCID:PMC3860454
• Roberto, M., Siggins, G. R. Nociceptin/orphanin fq presynaptically decreases gabaergic transmission and blocks the ethanol-induced increase of gaba release in central amygdala Proceedings of the National Academy of Sciences of the United States of America  2006 103:9715-9720  DOI:10.1073/pnas.0601899103  PMID:16788074  PMCID:PMC1480472
• Roberto, M., Bajo, M., Crawford, E., Madamba, S. G., Siggins, G. R. Chronic ethanol exposure and protracted abstinence alter nmda receptors in central amygdala Neuropsychopharmacology  2006 31:988-996  DOI:10.1038/sj.npp.1300840  PMID:16052
• Breese, G. R., Criswell, H. E., Carta, M., Dodson, P. D., Hanchar, H. J., Khisti, R. T., Mameli, M., Ming, Z., Morrow, A. L., Olsen, R. W., Otis, T. S., Parsons, L. H., et al. Basis of the gabamimetic profile of ethanol Alcoholism-Clinical and Experimental Research  2006 30:731-744  DOI:10.1111/j.0145-6008.2006.00086.x  PMID:16573592  PMCID:PMC2958095
• Bajo, M., Crawford, E. F., Roberto, M., Madamba, S. G., Siggins, G. R. Chronic morphine treatment alters expression of n-methyl-d-aspartate receptor subunits in the extended amygdala Journal of Neuroscience Research  2006 83:532-537  DOI:10.1002/jnr.20756  PMID:16453311
• Roberto, M., Treistman, S. N., Pietrzykowski, A. Z., Weiner, J., Galindo, R., Mameli, M., Valenzuela, F., Zhu, P. J., Zhang, T. A., Lovinger, D., Hendricson, A. H., Morrisett, R. Actions of acute and chronic ethanol on presynaptic terminals Alcoholism-Clinical and Experimental Research  2006 30:222-232  DOI:10.1111/j.1530-0277.2006.00030.x  PMID:16441271  PMCID:PMC4115792
• Woodward, J. J., Ron, D., Winder, D., Roberto, M. From blue states to up states: A regional view of nmda-ethanol interactions Alcoholism-Clinical and Experimental Research  2006 30:359-367  DOI:10.1111/j.1530-0277.2006.00040.x  PMID:16441285
• Slanina, K. A., Roberto, M., Schweitzer, P. Endocannabinoids restrict hippocampal long-term potentiation via cb1 Neuropharmacology  2005 49:660-668  DOI:10.1016/j.neurpharm.2005.04.021  PMID:15950248
• O'Dell, L. E., Purdy, R. H., Covey, D. F., Richardson, H. F., Roberto, M., Koob, G. F. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats Pharmacology, Biochemistry and Behavior  2005 81:543-550  DOI:10.1016/j.pbb.2005.03.020  PMID:15950269
• Siggins, G. R., Roberto, M., Nie, Z. G. The tipsy terminal: Presynaptic effects of ethanol Pharmacology & Therapeutics  2005 107:80-98  DOI:10.1016/j.pharmathera.2005.01.006  PMID:15963352
• Roberto, M., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Increased GABA release in the central amygdala of ethanol-dependent rats Journal of Neuroscience  2004 24:10159-10166  DOI:10.1523/jneurosci.3004-04.2004  PMID:15537886
• Schweitzer, P., Roberto, M., Madamba, S. G., Siggins, G. R. Gamma-hydroxybutyrate increases a potassium current and decreases the h-current in hippocampal neurons via gaba(b) receptors Journal of Pharmacology and Experimental Therapeutics  2004 311:172-179  DOI:10.1124/jpet.104.069534  PMID:15152029
• Roberto, M., Schweitzer, P., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis Journal of Neuroscience  2004 24:1594-1603  DOI:10.1523/jneurosci.5077-03.2004  PMID:14973247
• Roberto, M., Nelson, T. E., Ur, C. L., Brunelli, M., Sanna, P. P., Gruol, D. L. The transient depression of hippocampal CA1 LTP induced by chronic intermittent ethanol exposure is associated with an inhibition of the MAP kinase pathway European Journal of Neuroscience  2003 17:1646-1654  DOI:10.1046/j.1460-9568.2003.02614.x  PMID:12752382
• Roberto, M., Madamba, S. G., Moore, S. D., Tallent, M. K., Siggins, G. R. Ethanol increases gabaergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons Proceedings of the National Academy of Sciences of the United States of America  2003 100:2053-2058  DOI:10.1073/pnas.0437926100  PMID:12566570  PMCID:PMC149957
• Siggins, G. R., Martin, G., Roberto, M., Nie, Z. G., Madamba, S., De Lecea, L. Glutamatergic transmission in opiate and alcohol dependence Annals of the New York Academy of Sciences  2003 1003:196-211  DOI:10.1196/annals.1300.012  PMID:14684447
• Roberto, M., Nelson, T. E., Ur, C. L., Gruol, D. L. Long-term potentiation in the rat hippocampus is reversibly depressed by chronic intermittent ethanol exposure Journal of Neurophysiology  2002 87:2385-2397  DOI:10.1152/jn.00145.2001  PMID:11976376
• Sacchetti, B., Lorenzini, C. A., Baldi, E., Bucherelli, C., Roberto, M., Tassoni, G., Brunelli, M. Time-dependent inhibition of hippocampal LTP in vitro following contextual fear conditioning in the rat European Journal of Neuroscience  2002 15:143-150  DOI:10.1046/j.0953-816x.2001.01844.x  PMID:11860514
• Roberto, M., Scuri, R., Brunelli, M. Differential effects of pacap-38 on synaptic responses in rat hippocampal ca1 region Learning & Memory  2001 8:265-271  DOI:10.1101/lm.40501  PMID:11584073  PMCID:PMC311380
• Sacchetti, B., Lorenzini, C. A., Baldi, E., Bucherelli, C., Roberto, M., Tassoni, G., Brunelli, M. Pituitary adenylate cyclase-activating polypeptide hormone (pacap) at very low dosages improves memory in the rat Neurobiology of Learning and Memory  2001 76:1-6  DOI:10.1006/nlme.2001.4014  PMID:11525248
• Sacchetti, B., Lorenzini, C. A., Baldi, E., Bucherelli, C., Roberto, M., Tassoni, G., Brunelli, M. Long-lasting hippocampal potentiation and contextual memory consolidation European Journal of Neuroscience  2001 13:2291-2298  DOI:10.1046/j.0953-816x.2001.01609.x  PMID:11454033
• Mozzachiodi, R., Scuri, R., Roberto, M., Brunelli, M. Caulerpenyne, a toxin from the seaweed caulerpa taxifolia, depresses after hyperpolarization in invertebrate neurons Neuroscience  2001 107:519-526  DOI:10.1016/s0306-4522(01)00365-7  PMID:11719006
• Roberto, M., Brunelli, M. Pacap-38 enhances excitatory synaptic transmission in the rat hippocampal ca1 region Learning & Memory  2000 7:303-311  DOI:10.1101/lm.34200  PMID:11040262
• Brunelli, M., Garcia-Gil, M., Mozzachiodi, R., Roberto, M., Scuri, R., Traina, G., Zaccardi, M. L. Neurotoxic effects of caulerpenyne Progress in Neuro-Psychopharmacology & Biological Psychiatry  2000 24:939-954  DOI:10.1016/s0278-5846(00)00112-3  PMID:11041536