academic article

• Suarez, J., Khom, S., Alen, F., Natividad, L. A., Varodayan, F. P., Patel, R. R., Kirson, D., Arco, R., Ballesta, A., Bajo, M., Rubio, L., Martin-Fardon, R., et al. Cessation of fluoxetine treatment increases alcohol seeking during relapse and dysregulates endocannabinoid and glutamatergic signaling in the central amygdala Addiction Biology  2020  DOI:10.1111/adb.12813  PMID:31339221
• Fotio, Y., Borruto, A. M., Benvenuti, F., Demopulos, G., Gaitanaris, G., Roberto, M., Ciccocioppo, R. Activation of peroxisome proliferator-activated receptor gamma reduces alcohol drinking and seeking by modulating multiple mesocorticolimbic regions in rats Neuropsychopharmacology  2020  DOI:10.1038/s41386-020-0754-4  PMID:32610339
• Varodayan, F. P., Minnig, M. A., Steinman, M. Q., Oleata, C. S., Riley, M. W., Sabino, V., Roberto, M. PACAP regulation of central amygdala GABAergic synapses is altered by restraint stress Neuropharmacology  2020 168  DOI:10.1016/j.neuropharm.2019.107752  PMID:31476352  PMCID:PMC7048635
• Khom, S., Steinkellner, T., Hnasko, T. S., Roberto, M. Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala Science Advances  2020 6  DOI:10.1126/sciadv.aaz1050  PMID:32206720  PMCID:PMC7080445
• Agoglia, A. E., Zhu, M., Ying, R., Sidhu, H., Natividad, L. A., Wolfe, S. A., Buczynski, M. W., Contet, C., Parsons, L. H., Roberto, M., Herman, M. A. Corticotropin-releasing factor receptor-1 neurons in the lateral amygdala display selective sensitivity to acute and chronic ethanol exposure Eneuro  2020 7  DOI:10.1523/eneuro.0420-19.2020  PMID:32041742  PMCID:PMC7059189
• Spierling, S., de Guglielmo, G., Kirson, D., Kreisler, A., Roberto, M., George, O., Zorrilla, E. P. Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food Neuropsychopharmacology  2020 45:579-588  DOI:10.1038/s41386-019-0538-x  PMID:31593982  PMCID:PMC7021713
• Kirson, D., Oleata, C. S., Roberto, M. Taurine suppression of central amygdala GABAergic inhibitory signaling via glycine receptors is disrupted in alcohol dependence Alcoholism-Clinical and Experimental Research  2020  DOI:10.1111/acer.14252  PMID:31782155
• Khom, S., Wolfe, S. A., Patel, R. R., Kirson, D., Hedges, D. M., Varodayan, F. P., Bajo, M., Roberto, M. Alcohol Dependence and Withdrawal Impair Serotonergic Regulation of GABA Transmission in the Rat Central Nucleus of the Amygdala Journal of Neuroscience  2020 40:6842-6853  DOI:10.1523/jneurosci.0733-20.2020  PMID:32769108  PMCID:PMC7470924
• Frank, K., Abeynaike, S., Nikzad, R., Patel, R. R., Roberts, A. J., Roberto, M., Paust, S. Alcohol dependence promotes systemic IFN-gamma and IL-17 responses in mice PLoS One  2020 15  DOI:10.1371/journal.pone.0239246  PMID:33347446  PMCID:PMC7751976
• Pavon, F. J., Polis, I., Stouffer, D. G., Roberto, M., Martin-Fardon, R., de Fonseca, F. R., Parsons, L. H., Serrano, A. COX-2 Inhibition Antagonizes Intra-Accumbens 2-Arachidonoylglycerol-Mediated Reduction in Ethanol Self-Administration in Rats Alcoholism-Clinical and Experimental Research  2020  DOI:10.1111/acer.14456  PMID:32944989
• Hedges, D. M., Yorgason, J. T., Brundage, J. N., Wadsworth, H. A., Williams, B., Steffensen, S. C., Roberto, M. Corticotropin releasing factor, but not alcohol, modulates norepinephrine release in the rat central nucleus of the amygdala Neuropharmacology  2020 179  DOI:10.1016/j.neuropharm.2020.108293  PMID:32871155  PMCID:PMC7572647
• Natividad, L. A., Steinman, M. Q., McGinn, M. A., Sureshchandra, S., Kerr, T. M., Ciccocioppo, R., Messaoudi, I., Edwards, S., Roberto, M. Impaired hypothalamic feedback dysregulates brain glucocorticoid signaling in genetically-selected Marchigian Sardinian alcohol-preferring rats Addiction Biology  2020  DOI:10.1111/adb.12978  PMID:33142367
• Steinman, M. Q., Kirson, D., Wolfe, S. A., Khom, S., D'Ambrosio, S. R., Bagsic, S. S. R., Bajo, M., Vlkolinsky, R., Hoang, N. K., Singhal, A., Sureshchandra, S., Oleata, C. S., et al. Importance of sex and trauma context on circulating cytokines and amygdalar GABAergic signaling in a comorbid model of posttraumatic stress and alcohol use disorders Molecular Psychiatry  2020  DOI:10.1038/s41380-020-00920-2  PMID:33087855
• Warden, A. S., Wolfe, S. A., Khom, S., Varodayan, F. P., Patel, R. R., Steinman, M. Q., Bajo, M., Montgomery, S. E., Vlkolinsky, R., Nadav, T., Polis, I., Roberts, A. J., et al. Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers Biological Psychiatry  2020 88:910-921  DOI:10.1016/j.biopsych.2020.05.011  PMID:32680583  PMCID:PMC7674270
• Warden, A. S., Wolfe, S. A., Khom, S., Varodayan, F. P., Patel, R. R., Steinman, M. Q., Bajo, M., Montgomery, S. E., Vlkolinsky, R., Nadav, T., Polis, I., Roberts, A. J., et al. Microglia Control Escalation of Drinking in Alcohol-Dependent Mice: Genomic and Synaptic Drivers Biological Psychiatry  2020 88:910-921  DOI:10.1016/j.biopsych.2020.05.011  PMID:32680583  PMCID:PMC7674270
• Demoret, R. M., Baker, M. A., Ohtawa, M., Chen, S. M., Lam, C. C., Khom, S., Roberto, M., Forli, S., Houk, K. N., Shenvi, R. A. Synthetic, Mechanistic, and Biological Interrogation of Ginkgo biloba Chemical Space En Route to (-)-Bilobalide Journal of the American Chemical Society  2020 142:18599-18618  DOI:10.1021/jacs.0c08231  PMID:32991152  PMCID:PMC7727090
• Bajo, M., Patel, R. R., Hedges, D. M., Varodayan, F. P., Vlkolinsky, R., Davis, T. D., Burkart, M. D., Blednov, Y. A., Roberto, M. Role of MyD88 in IL-1β and ethanol modulation of GABAergic transmission in the central amygdala Brain Sciences  2019 9  DOI:10.3390/brainsci9120361  PMID:31817854  PMCID:PMC6956324
• Pavon, F. J., Serrano, A., Stouffer, D. G., Polis, I., Roberto, M., Cravatt, B. F., Martin-Fardon, R., de Fonseca, F. R., Parsons, L. H. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice Addiction Biology  2019 24:1204-1215  DOI:10.1111/adb.12695  PMID:30421483  PMCID:PMC6551299
• Roberts, A. J., Khom, S., Bajo, M., Vlkolinsky, R., Polis, I., Cates-Gatto, C., Roberto, M., Gruol, D. L. Increased IL-6 expression in astrocytes is associated with emotionality, alterations in central amygdala GABAergic transmission, and excitability during alcohol withdrawal Brain Behavior and Immunity  2019 82:188-202  DOI:10.1016/j.bbi.2019.08.185  PMID:31437534  PMCID:PMC6800653
• Cannella, N., Ubaldi, M., Masi, A., Bramucci, M., Roberto, M., Bifone, A., Ciccocioppo, R. Building better strategies to develop new medications in Alcohol Use Disorder: Learning from past success and failure to shape a brighter future Neuroscience and Biobehavioral Reviews  2019 103:384-398  DOI:10.1016/j.neubiorev.2019.05.014  PMID:31112713  PMCID:PMC6692218
• Blednov, Y. A., Bajo, M., Roberts, A. J., Da Costa, A. J., Black, M., Edmunds, S., Mayfield, J., Roberto, M., Homanics, G. E., Lasek, A. W., Hitzemann, R. J., Harris, R. A. Scn4b regulates the hypnotic effects of ethanol and other sedative drugs Genes Brain and Behavior  2019 18  DOI:10.1111/gbb.12562  PMID:30817077  PMCID:PMC6612599
• Tunstall, B. J., Kirson, D., Zallar, L. J., McConnell, S. A., Vendruscolo, J. C. M., Ho, C. P., Oleata, C. S., Khom, S., Manning, M., Lee, M. R., Leggio, L., Koob, G. F., et al. Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala PLoS Biology  2019 17  DOI:10.1371/journal.pbio.2006421  PMID:30990816  PMCID:PMC6467366
• Jimenez, V. A., Herman, M. A., Carlson, V. C. C., Walter, N. A., Grant, K. A., Roberto, M. Synaptic adaptations in the central amygdala and hypothalamic paraventricular nucleus associated with protracted ethanol abstinence in male rhesus monkeys Neuropsychopharmacology  2019 44:982-993  DOI:10.1038/s41386-018-0290-7  PMID:30555160
• Patel, R. R., Khom, S., Steinman, M. Q., Varodayan, F. P., Kiosses, W. B., Hedges, D. M., Vlkolinsky, R., Nadav, T., Polis, I., Bajo, M., Roberts, A. J., Roberto, M. IL-1β expression is increased and regulates GABA transmission following chronic ethanol in mouse central amygdala Brain Behavior and Immunity  2019 75:208-219  DOI:10.1016/j.bbi.2018.10.009
• McClatchy, D. B., Yu, N. K., Martinez-Bartolome, S., Patel, R., Pelletier, A. R., Lavalle-Adam, M., Powell, S. B., Roberto, M., Yates III, J. R. Structural analysis of hippocampal kinase signal transduction ACS Chemical Neuroscience  2018 9:3072-3085  DOI:10.1021/acschemneuro.8b00284  PMID:30053369
• Roberto, M. Commentary on the Forth International Congress on "Alcoholism and stress: a framework for future treatment strategies" Alcohol  2018 72:1-2  DOI:10.1016/j.alcohol.2018.08.001  PMID:30241916
• Stopponi, S., Fotio, Y., Domi, A., Borruto, A. M., Natividad, L., Roberto, M., Ciccocioppo, R., Cannella, N. Inhibition of fatty acid amide hydrolase in the central amygdala alleviates co-morbid expression of innate anxiety and excessive alcohol intake Addiction Biology  2018 23:1223-1232  DOI:10.1111/adb.12573  PMID:29071769
• Frantz, K., Roberto, M., Mason, B., Koob, G. F., Volkow, N., de Fonseca, F. R. Larry Parsons: Researcher, mentor, and friend Addiction Biology  2018 23:1204-1206  DOI:10.1111/adb.12686  PMID:30485629
• Varodayan, F. P., Khom, S., Patel, R. R., Steinman, M. Q., Hedges, D. M., Oleata, C. S., Homanics, G. E., Roberto, M., Bajo, M. Role of TLR4 in the modulation of central amygdala GABA transmission by CRF following restraint stress Alcohol and Alcoholism  2018 53:642-649  DOI:10.1093/alcalc/agx114  PMID:29309503  PMCID:PMC6203127
• Roberto, M., de Fonseca, F. R. Special issue honoring the legacy of Loren H. Parsons Addiction Biology  2018 23:1203-1203  DOI:10.1111/adb.12693  PMID:30378726
• Natividad, L. A., Steinman, M. Q., Laredo, S. A., Irimia, C., Polis, I. Y., Lintz, R., Buczynski, M. W., Martin-Fardon, R., Roberto, M., Parsons, L. H. Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility Addiction Biology  2018 23:1117-1129  DOI:10.1111/adb.12568  PMID:28940879  PMCID:PMC5862723
• Serrano, A., Pavon, F. J., Buczynski, M. W., Schlosburg, J., Natividad, L. A., Polis, I. Y., Stouffer, D. G., Zorrilla, E. P., Roberto, M., Cravatt, B. F., Martin-Fardon, R., de Fonseca, F. R., et al. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake Neuropsychopharmacology  2018 43:1840-1850  DOI:10.1038/s41386-018-0055-3  PMID:29748627  PMCID:PMC6046053
• Blasio, A., Wang, J., Wang, D., Varodayan, F. P., Pomrenze, M. B., Miller, J., Lee, A. M., McMahon, T., Gyawali, S., Wang, H. Y., Roberto, M., McHardy, S., et al. Novel small-molecule inhibitors of protein kinase c epsilon reduced ethanol consumption in mice Biological Psychiatry  2018 84:193-201  DOI:10.1016/j.biopsych.2017.10.017  PMID:29198469  PMCID:PMC5984071
• Varodayan, F. P., Sidhu, H., Kreifeldt, M., Roberto, M., Contet, C. Morphological and functional evidence of increased excitatory signaling in the prelimbic cortex during ethanol withdrawal Neuropharmacology  2018 133:470-480  DOI:10.1016/j.neuropharm.2018.02.014  PMID:29471053  PMCID:PMC5865397
• Kirson, D., Oleata, C. S., Parsons, L. H., Ciccocioppo, R., Roberto, M. CB1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats Addiction Biology  2018 23:676-688  DOI:10.1111/adb.12525  PMID:28656627  PMCID:PMC5745318
• Varodayan, F. P., Correia, D., Kirson, D., Khom, S., Oleata, C. S., Luu, G., Schweitzer, P., Roberto, M. CRF modulates glutamate transmission in the central amygdala of naive and ethanol-dependent rats Neuropharmacology  2017 125:418-428  DOI:10.1016/j.neuropharm.2017.08.009  PMID:28807676  PMCID:PMC5586541
• Natividad, L. A., Buczynski, M. W., Herman, M. A., Kirson, D., Oleata, C. S., Irimia, C., Polis, I., Ciccocioppo, R., Roberto, M., Parsons, L. H. Constitutive increases in amygdalar corticotropin-releasing factor and fatty acid amide hydrolase drive an anxious phenotype Biological Psychiatry  2017 82:500-510  DOI:10.1016/j.biopsych.2017.01.005  PMID:28209423  PMCID:PMC5509512
• Varodayan, F. P., Logrip, M. L., Roberto, M. P/Q-type voltage -gated calcium channels mediate the ethanol and CRF sensitivity of central amygdala GABAergic synapses Neuropharmacology  2017 125:197-206  DOI:10.1016/j.neuropharm.2017.07.017  PMID:28734867
• Cippitelli, A., Domi, E., Ubaldi, M., Douglas, J. C., Li, H. W., Demopulos, G., Gaitanaris, G., Roberto, M., Drew, P. D., Kane, C. J. M., Ciccocioppo, R. Protection against alcohol-induced neuronal and cognitive damage by the PPARγ receptor agonist pioglitazone Brain Behavior and Immunity  2017 64:320-329  DOI:10.1016/j.bbi.2017.02.001  PMID:28167117
• Roberto, M., Varodayan, F. P. Synaptic targets: Chronic alcohol actions Neuropharmacology  2017 122:85-99  DOI:10.1016/j.neuropharm.2017.01.013  PMID:28108359  PMCID:PMC5479718
• Borghese, C. M., Herman, M., Snell, L. D., Lawrence, K. J., Lee, H. Y., Backos, D. S., Vanderlinden, L. A., Harris, R. A., Roberto, M., Hoffman, P. L., Tabakoff, B. Novel molecule exhibiting selective affinity for GABA(A) receptor subtypes Scientific Reports  2017 7  DOI:10.1038/s41598-017-05966-x  PMID:28740086  PMCID:PMC5524711
• Varodayan, F. P., Bajo, M., Soni, N., Luu, G., Madamba, S. G., Schweitzer, P., Roberto, M. Chronic alcohol exposure disrupts CB1 regulation of GABAergic transmission in the rat basolateral amygdala Addiction Biology  2017 22:766-778  DOI:10.1111/adb.12369  PMID:26786379  PMCID:PMC4956605
• Varodayan, F. P., de Guglielmo, G., Logrip, M. L., George, O., Roberto, M. Alcohol dependence disrupts amygdalar L-type voltage-gated calcium channel mechanisms Journal of Neuroscience  2017 37:4593-4603  DOI:10.1523/jneurosci.3721-16.2017  PMID:28363981  PMCID:PMC5413190
• Schmeichel, B. E., Herman, M. A., Roberto, M., Koob, G. F. Hypocretin neurotransmission within the central amygdala mediates escalated cocaine self-administration and stress-induced reinstatement in rats Biological Psychiatry  2017 81:606-615  DOI:10.1016/j.biopsych.2016.06.010  PMID:27567312  PMCID:PMC5161745
• Logrip, M. L., Oleata, C., Roberto, M. Sex differences in responses of the basolateral-central amygdala circuit to alcohol, corticosterone and their interaction Neuropharmacology  2017 114:123-134  DOI:10.1016/j.neuropharm.2016.11.021  PMID:27899281
• Harris, R. A., Bajo, M., Bell, R. L., Blednov, Y. A., Varodayan, F. P., Truitt, J. M., de Guglielmo, G., Lasek, A. W., Logrip, M. L., Vendruscolo, L. F. Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents Journal of Neuroscience  2017 37:1139-1155  DOI:10.1523/jneurosci.2002-16.2016  PMID:27986929  PMCID:PMC5296793
• Roberto, M., Spierling, S. R., Kirson, D., Zorrilla, E. P. Corticotropin-Releasing Factor (CRF) and Addictive Behaviors International Review of Neurobiology  2017 136:5-51  DOI:10.1016/bs.im.2017.06.004  PMID:29056155
• Herman, M. A., Contet, C., Roberto, M. A functional switch in tonic GABA currents alters the output of central amygdala corticotropin releasing factor receptor-1 neurons following chronic ethanol exposure Journal of Neuroscience  2016 36:10729-10741  DOI:10.1523/jneurosci.1267-16.2016  PMID:27798128  PMCID:PMC5083004
• Bajo, M., Montgomery, S. E., Cates, L. N., Nadav, T., Delucchi, A. M., Cheng, K., Yin, H., Crawford, E. F., Roberts, A. J., Roberto, M. Evaluation of TLR4 inhibitor, T5342126, in modulation of ethanol-drinking behavior in alcohol-dependent mice Alcohol and Alcoholism  2016 51:541-548  DOI:10.1093/alcalc/agw026  PMID:27151970  PMCID:PMC5004745
• Schweitzer, P., Cates-Gatto, C., Varodayan, F. P., Nadav, T., Roberto, M., Lasek, A. W., Roberts, A. J. Dependence-induced ethanol drinking and GABA neurotransmission are altered in Alk deficient mice Neuropharmacology  2016 107:1-8  DOI:10.1016/j.neuropharm.2016.03.003  PMID:26946429  PMCID:PMC4912883
• Varodayan, F. P., Soni, N., Bajo, M., Luu, G., Madamba, S. G., Schweitzer, P., Parsons, L. H., Roberto, M. Chronic ethanol exposure decreases CB1 receptor function at GABAergic synapses in the rat central amygdala Addiction Biology  2016 21:788-801  DOI:10.1111/adb.12256  PMID:25940135  PMCID:PMC4635109
• Herman, M. A., Varodayan, F. P., Oleata, C. S., Luu, G., Kirson, D., Heilig, M., Ciccocioppo, R., Roberto, M. Glutamatergic transmission in the central nucleus of the amygdala is selectively altered in Marchigian Sardinian alcohol-preferring rats: Alcohol and CRF effects Neuropharmacology  2016 102:21-31  DOI:10.1016/j.neuropharm.2015.10.027  PMID:26519902  PMCID:PMC4698227
• Buczynski, M. W., Herman, M. A., Hsu, K. L., Natividad, L. A., Irimia, C., Polis, I. Y., Pugh, H., Chang, J. W., Niphakis, M. J., Cravatt, B. F., Roberto, M., Parsons, L. H. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure Proceedings of the National Academy of Sciences of the United States of America  2016 113:1086-1091  DOI:10.1073/pnas.1522672113  PMID:26755579  PMCID:PMC4743781
• Herman, M. A., Roberto, M. Cell-type-specific tonic GABA signaling in the rat central amygdala is selectively altered by acute and chronic ethanol Addiction Biology  2016 21:72-86  DOI:10.1111/adb.12181  PMID:25170988  PMCID:PMC4345144
• Cui, C., Noronha, A., Warren, K. R., Koob, G. F., Sinha, R., Thakkar, M., Matochik, J., Crews, F. T., Chandler, L. J., Pfefferbaum, A., Becker, H. C., Lovinger, D., et al. Brain pathways to recovery from alcohol dependence Alcohol  2015 49:435-452  DOI:10.1016/j.alcohol.2015.04.006  PMID:26074423  PMCID:PMC4468789
• Herman, M. A., Sidhu, H., Stouffer, D. G., Kreifeldt, M., Le, D., Cates-Gatto, C., Munoz, M. B., Roberts, A. J., Parsons, L. H., Roberto, M., Wickman, K., Slesinger, P. A., et al. GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol Proceedings of the National Academy of Sciences of the United States of America  2015 112:7091-7096  DOI:10.1073/pnas.1416146112  PMID:25964320  PMCID:PMC4460485
• Repunte-Canonigo, V., Herman, M. A., Kawamura, T., Kranzler, H. R., Sherva, R., Gelernter, J., Farrer, L. A., Roberto, M., Sanna, P. P. Nf1 regulates alcohol dependence-associated excessive drinking and gamma-aminobutyric acid release in the central amygdala in mice and is associated with alcohol dependence in humans Biological Psychiatry  2015 77:870-879  DOI:10.1016/j.biopsych.2014.07.031  PMID:25483400  PMCID:PMC4428692
• Gilpin, N. W., Herman, M. A., Roberto, M. The central amygdala as an integrative hub for anxiety and alcohol use disorders Biological Psychiatry  2015 77:859-869  DOI:10.1016/j.biopsych.2014.09.008  PMID:25433901  PMCID:PMC4398579
• Bajo, M., Varodayan, F. P., Madamba, S. G., Roberts, A. J., Casal, L. M., Oleata, C. S., Siggins, G. R., Roberto, M. IL-1 interacts with ethanol effects on GABAergic transmission in the mouse central amygdala Frontiers in Pharmacology  2015 6:49  DOI:10.3389/fphar.2015.00049  PMID:25852553  PMCID:PMC4365713
• Cippitelli, A., Ayanwuyi, L. O., Barbier, E., Domi, E., Lerma-Cabrera, J. M., Carvajal, F., Scuppa, G., Li, H., Ubaldi, M., Heilig, M., Roberto, M., Ciccocioppo, R. Polymorphism in the corticotropin-releasing factor receptor 1 (CRF1-R) gene plays a role in shaping the high anxious phenotype of Marchigian Sardinian alcohol-preferring (msP) rats Psychopharmacology  2015 232:1083-1093  DOI:10.1007/s00213-014-3743-7  PMID:25260340  PMCID:PMC4339612
• Bajo, M., Herman, M. A., Varodayan, F. P., Oleata, C. S., Madamba, S. G., Harris, R. A., Blednov, Y. A., Roberto, M. Role of the IL-1 receptor antagonist in ethanol-induced regulation of GABAergic transmission in the central amygdala Brain Behavior and Immunity  2015 45:189-197  DOI:10.1016/j.bbi.2014.11.011  PMID:25479427  PMCID:PMC4405101
• Grieder, T. E., Herman, M. A., Contet, C., Tan, L. A., Vargas-Perez, H., Cohen, A., Chwalek, M., Maal-Bared, G., Freiling, J., Schlosburg, J. E., Clarke, L., Crawford, E., et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation Nature Neuroscience  2014 17:1751-1758  DOI:10.1038/nn.3872  PMID:25402857  PMCID:PMC4241147
• Ciccocioppo, R., Stopponi, S., Economidou, D., Kuriyama, M., Kinoshita, H., Heilig, M., Roberto, M., Weiss, F., Teshima, K. Chronic treatment with novel brain-penetrating selective NOP receptor agonist MT-7716 reduces alcohol drinking and seeking in the rat Neuropsychopharmacology  2014 39:2601-2610  DOI:10.1038/npp.2014.113  PMID:24863033  PMCID:PMC4207340
• Kallupi, M., Varodayan, F. P., Oleata, C. S., Correia, D., Luu, G., Roberto, M. Nociceptin/orphanin FQ decreases glutamate transmission and blocks ethanol-induced effects in the central amygdala of naive and ethanol-dependent rats Neuropsychopharmacology  2014 39:1081-1092  DOI:10.1038/npp.2013.308  PMID:24169802  PMCID:PMC3957102
• Gilpin, N. W., Roberto, M., Koob, G. F., Schweitzer, P. Kappa opioid receptor activation decreases inhibitory transmission and antagonizes alcohol effects in rat central amygdala Neuropharmacology  2014 77:294-302  DOI:10.1016/j.neuropharm.2013.10.005  PMID:24157490  PMCID:PMC3873141
• Ciccocioppo, R., de Guglielmo, G., Hansson, A. C., Ubaldi, M., Kallupi, M., Cruz, M. T., Oleata, C. S., Heilig, M., Roberto, M. Restraint stress alters nociceptin/orphanin FQ and CRF systems in the rat central amygdala: significance for anxiety-like behaviors Journal of Neuroscience  2014 34:363-372  DOI:10.1523/jneurosci.2400-13.2014  PMID:24403138  PMCID:PMC3870926
• Kallupi, M., Wee, S., Edwards, S., Whitfield, T. W., Oleata, C. S., Luu, G., Schmeichel, B. E., Koob, G. F., Roberto, M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction Biological Psychiatry  2013 74:520-528  DOI:10.1016/j.biopsych.2013.04.028  PMID:23751206  PMCID:PMC3773286
• Herman, M. A., Kallupi, M., Luu, G., Oleata, C. S., Heilig, M., Koob, G. F., Ciccocioppo, R., Roberto, M. Enhanced gabaergic transmission in the central nucleus of the amygdala of genetically selected marchigian sardinian rats: Alcohol and crf effects Neuropharmacology  2013 67:337-348  DOI:10.1016/j.neuropharm.2012.11.026  PMID:23220399  PMCID:PMC3562384
• Cui, C. H., Noronha, A., Morikawa, H., Alvarez, V. A., Stuber, G. D., Szumlinski, K. K., Kash, T. L., Roberto, M., Wilcox, M. V. New insights on neurobiological mechanisms underlying alcohol addiction Neuropharmacology  2013 67:223-232  DOI:10.1016/j.neuropharm.2012.09.022  PMID:23159531  PMCID:PMC3562413
• Herman, M. A., Contet, C., Justice, N. J., Vale, W., Roberto, M. Novel subunit-specific tonic GABA currents and differential effects of ethanol in the central amygdala of CRF receptor-1 reporter mice Journal of Neuroscience  2013 33:3284-3298  DOI:10.1523/jneurosci.2490-12.2013  PMID:23426657  PMCID:PMC3711798
• Cruz, M. T., Herman, M. A., Cote, D. M., Ryabinin, A. E., Roberto, M. Ghrelin increases gabaergic transmission and interacts with ethanol actions in the rat central nucleus of the amygdala Neuropsychopharmacology  2013 38:364-375  DOI:10.1038/npp.2012.190  PMID:22968812  PMCID:PMC3527109
• Ayanwuyi, L. O., Carvajal, F., Lerma-Cabrera, J. M., Domi, E., Bjork, K., Ubaldi, M., Heilig, M., Roberto, M., Ciccocioppo, R., Cippitelli, A. Role of a genetic polymorphism in the corticotropin-releasing factor receptor 1 gene in alcohol drinking and seeking behaviors of marchigian sardinian alcohol-preferring rats Frontiers in Psychiatry  2013 4:23  DOI:10.3389/fpsyt.2013.00023  PMID:23630503  PMCID:PMC3624086
• Lovinger, D. M., Roberto, M. Synaptic effects induced by alcohol Current Topics in Behavioral Neurosciences  2013 13:31-86  DOI:10.1007/7854_2011_143  PMID:21786203  PMCID:PMC4791588
• Roberto, M., Gilpin, N. W., Siggins, G. R. The central amygdala and alcohol: Role of γ-aminobutyric acid, glutamate, and neuropeptides Cold Spring Harbor Perspectives in Medicine  2012 2:a012195  DOI:10.1101/cshperspect.a012195  PMID:23085848  PMCID:PMC3543070
• Cruz, M. T., Herman, M. A., Kallupi, M., Roberto, M. Nociceptin/orphanin fq blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure Biological Psychiatry  2012 71:666-676  DOI:10.1016/j.biopsych.2011.10.032  PMID:22153590  PMCID:PMC3838304
• Gilpin, N. W., Roberto, M. Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence Neuroscience and Biobehavioral Reviews  2012 36:873-888  DOI:10.1016/j.neubiorev.2011.11.002  PMID:22101113  PMCID:PMC3325612
• Bajo, M., Roberto, M., Madamba, S. G., Siggins, G. R. Neuroadaptation of gabaergic transmission in the central amygdala during chronic morphine treatment Addiction Biology  2011 16:551-564  DOI:10.1111/j.1369-1600.2010.00269.x  PMID:21182569  PMCID:PMC3117063
• Gilpin, N. W., Misra, K., Herman, M. A., Cruz, M. T., Koob, G. F., Roberto, M. Neuropeptide y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence Biological Psychiatry  2011 69:1091-1099  DOI:10.1016/j.biopsych.2011.02.004  PMID:21459365  PMCID:PMC3090491
• Cruz, M. T., Bajo, M., Maragnoli, M. E., Tabakoff, B., Siggins, G. R., Roberto, M. Type 7 adenylyl cyclase is involved in the ethanol and crf sensitivity of gabaergic synapses in mouse central amygdala Frontiers in Neuroscience  2011 4:207  DOI:10.3389/fnins.2010.00207  PMID:21258618  PMCID:PMC3024005
• Roberto, M., Cruz, M., Bajo, M., Siggins, G. R., Parsons, L. H., Schweitzer, P. The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala Neuropsychopharmacology  2010 35:1962-1972  DOI:10.1038/npp.2010.70  PMID:20463657  PMCID:PMC2904853
• Roberto, M., Cruz, M. T., Gilpin, N. W., Sabin, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., et al. Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence Biological Psychiatry  2010 67:831-839  DOI:10.1016/j.biopsych.2009.11.007  PMID:20060104  PMCID:PMC2883449
• Cottone, P., Sabino, V., Roberto, M., Bajo, M., Pockros, L., Frihauf, J. B., Fekete, E. M., Steardo, L., Rice, K. C., Grigoriadis, D. E., Conti, B., Koob, G. F., et al. CRF system recruitment mediates dark side of compulsive eating Proceedings of the National Academy of Sciences of the United States of America  2009 106:20016-20020  DOI:10.1073/pnas.0908789106  PMID:19901333  PMCID:PMC2785284
• Silberman, Y., Bajo, M., Chappell, A. M., Christian, D. T., Cruz, M., Diaz, M. R., Kash, T., Lack, A. K., Messing, R. O., Siggins, G. R., Winder, D., Roberto, M., et al. Neurobiological mechanisms contributing to alcohol-stress-anxiety interactions Alcohol  2009 43:509-519  DOI:10.1016/j.alcohol.2009.01.002  PMID:19913194  PMCID:PMC2814297
• Witkiewitz, K., Holmes, A., Ray, L. A., Murphy, J. G., Richardson, H. N., Chen, Y. C., McDevitt-Murphy, M. E., Cruz, M. T., Roberto, M. Young investigator award symposium Alcohol  2009 43:499-508  DOI:10.1016/j.alcohol.2009.06.004  PMID:19913193
• Bajo, M., Roberto, M., Schweitzer, P. Differential alteration of hippocampal excitatory synaptic transmission by cannabinoid ligands Journal of Neuroscience Research  2009 87:766-775  DOI:10.1002/jnr.21889  PMID:18816788  PMCID:PMC3816768
• Kang-Park, M. H., Kieffer, B. L., Roberts, A. J., Roberto, M., Madamba, S. G., Siggins, G. R., Moore, S. D. Mu-opioid receptors selectively regulate basal inhibitory transmission in the central amygdala: Lack of ethanol interactions Journal of Pharmacology and Experimental Therapeutics  2009 328:284-293  DOI:10.1124/jpet.108.140749  PMID:18854491  PMCID:PMC2685907
• Kenny, P. J., Chartoff, E., Roberto, M., Carlezon, W. A., Markou, A. Nmda receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: Role of the ventral tegmental area and central nucleus of the amygdala Neuropsychopharmacology  2009 34:266-281  DOI:10.1038/npp.2008.58  PMID:18418357  PMCID:PMC2654386
• Nie, Z. G., Zorrilla, E. P., Madamba, S. G., Rice, K. C., Roberto, M., Siggins, G. R. Presynaptic crf(1) receptors mediate the ethanol enhancement of gabaergic transmission in the mouse central amygdala Thescientificworldjournal  2009 9:68-85  DOI:10.1100/tsw.2009.1  PMID:19151899  PMCID:PMC3053445
• Bajo, M., Cruz, M. T., Siggins, G. R., Messing, R., Roberto, M. Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala Proceedings of the National Academy of Sciences of the United States of America  2008 105:8410-8415  DOI:10.1073/pnas.0802302105  PMID:18541912  PMCID:PMC2448850
• Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., Koob, G. F. Cellular and behavioral interactions of gabapentin with alcohol dependence Journal of Neuroscience  2008 28:5762-5771  DOI:10.1523/jneurosci.0575-08.2008  PMID:18509038  PMCID:PMC2493536
• Cruz, M. T., Bajo, M., Schweitzer, P., Roberto, M. Shared mechanisms of alcohol and other drugs Alcohol Research and Health  2008 31:137-147  PMID:23584815  PMCID:PMC3860454
• Roberto, M., Siggins, G. R. Nociceptin/orphanin fq presynaptically decreases gabaergic transmission and blocks the ethanol-induced increase of gaba release in central amygdala Proceedings of the National Academy of Sciences of the United States of America  2006 103:9715-9720  DOI:10.1073/pnas.0601899103  PMID:16788074  PMCID:PMC1480472
• Roberto, M., Bajo, M., Crawford, E., Madamba, S. G., Siggins, G. R. Chronic ethanol exposure and protracted abstinence alter nmda receptors in central amygdala Neuropsychopharmacology  2006 31:988-996  DOI:10.1038/sj.npp.1300840  PMID:16052
• Breese, G. R., Criswell, H. E., Carta, M., Dodson, P. D., Hanchar, H. J., Khisti, R. T., Mameli, M., Ming, Z., Morrow, A. L., Olsen, R. W., Otis, T. S., Parsons, L. H., et al. Basis of the gabamimetic profile of ethanol Alcoholism-Clinical and Experimental Research  2006 30:731-744  DOI:10.1111/j.0145-6008.2006.00086.x  PMID:16573592  PMCID:PMC2958095
• Bajo, M., Crawford, E. F., Roberto, M., Madamba, S. G., Siggins, G. R. Chronic morphine treatment alters expression of n-methyl-d-aspartate receptor subunits in the extended amygdala Journal of Neuroscience Research  2006 83:532-537  DOI:10.1002/jnr.20756  PMID:16453311
• Roberto, M., Treistman, S. N., Pietrzykowski, A. Z., Weiner, J., Galindo, R., Mameli, M., Valenzuela, F., Zhu, P. J., Zhang, T. A., Lovinger, D., Hendricson, A. H., Morrisett, R. Actions of acute and chronic ethanol on presynaptic terminals Alcoholism-Clinical and Experimental Research  2006 30:222-232  DOI:10.1111/j.1530-0277.2006.00030.x  PMID:16441271  PMCID:PMC4115792
• Woodward, J. J., Ron, D., Winder, D., Roberto, M. From blue states to up states: A regional view of nmda-ethanol interactions Alcoholism-Clinical and Experimental Research  2006 30:359-367  DOI:10.1111/j.1530-0277.2006.00040.x  PMID:16441285
• Slanina, K. A., Roberto, M., Schweitzer, P. Endocannabinoids restrict hippocampal long-term potentiation via cb1 Neuropharmacology  2005 49:660-668  DOI:10.1016/j.neurpharm.2005.04.021  PMID:15950248
• O'Dell, L. E., Purdy, R. H., Covey, D. F., Richardson, H. F., Roberto, M., Koob, G. F. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats Pharmacology, Biochemistry and Behavior  2005 81:543-550  DOI:10.1016/j.pbb.2005.03.020  PMID:15950269
• Siggins, G. R., Roberto, M., Nie, Z. G. The tipsy terminal: Presynaptic effects of ethanol Pharmacology & Therapeutics  2005 107:80-98  DOI:10.1016/j.pharmathera.2005.01.006  PMID:15963352
• Roberto, M., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Increased GABA release in the central amygdala of ethanol-dependent rats Journal of Neuroscience  2004 24:10159-10166  DOI:10.1523/jneurosci.3004-04.2004  PMID:15537886
• Schweitzer, P., Roberto, M., Madamba, S. G., Siggins, G. R. Gamma-hydroxybutyrate increases a potassium current and decreases the h-current in hippocampal neurons via gaba(b) receptors Journal of Pharmacology and Experimental Therapeutics  2004 311:172-179  DOI:10.1124/jpet.104.069534  PMID:15152029
• Roberto, M., Schweitzer, P., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis Journal of Neuroscience  2004 24:1594-1603  DOI:10.1523/jneurosci.5077-03.2004  PMID:14973247
• Roberto, M., Nelson, T. E., Ur, C. L., Brunelli, M., Sanna, P. P., Gruol, D. L. The transient depression of hippocampal CA1 LTP induced by chronic intermittent ethanol exposure is associated with an inhibition of the MAP kinase pathway European Journal of Neuroscience  2003 17:1646-1654  DOI:10.1046/j.1460-9568.2003.02614.x  PMID:12752382
• Roberto, M., Madamba, S. G., Moore, S. D., Tallent, M. K., Siggins, G. R. Ethanol increases gabaergic transmission at both pre- and postsynaptic sites in rat central amygdala neurons Proceedings of the National Academy of Sciences of the United States of America  2003 100:2053-2058  DOI:10.1073/pnas.0437926100  PMID:12566570  PMCID:PMC149957
• Siggins, G. R., Martin, G., Roberto, M., Nie, Z. G., Madamba, S., De Lecea, L. Glutamatergic transmission in opiate and alcohol dependence Annals of the New York Academy of Sciences  2003 1003:196-211  DOI:10.1196/annals.1300.012  PMID:14684447
• Roberto, M., Nelson, T. E., Ur, C. L., Gruol, D. L. Long-term potentiation in the rat hippocampus is reversibly depressed by chronic intermittent ethanol exposure Journal of Neurophysiology  2002 87:2385-2397  DOI:10.1152/jn.00145.2001  PMID:11976376
• Sacchetti, B., Lorenzini, C. A., Baldi, E., Bucherelli, C., Roberto, M., Tassoni, G., Brunelli, M. Time-dependent inhibition of hippocampal LTP in vitro following contextual fear conditioning in the rat European Journal of Neuroscience  2002 15:143-150  DOI:10.1046/j.0953-816x.2001.01844.x  PMID:11860514
• Roberto, M., Scuri, R., Brunelli, M. Differential effects of pacap-38 on synaptic responses in rat hippocampal ca1 region Learning & Memory  2001 8:265-271  DOI:10.1101/lm.40501  PMID:11584073  PMCID:PMC311380
• Sacchetti, B., Lorenzini, C. A., Baldi, E., Bucherelli, C., Roberto, M., Tassoni, G., Brunelli, M. Pituitary adenylate cyclase-activating polypeptide hormone (pacap) at very low dosages improves memory in the rat Neurobiology of Learning and Memory  2001 76:1-6  DOI:10.1006/nlme.2001.4014  PMID:11525248
• Sacchetti, B., Lorenzini, C. A., Baldi, E., Bucherelli, C., Roberto, M., Tassoni, G., Brunelli, M. Long-lasting hippocampal potentiation and contextual memory consolidation European Journal of Neuroscience  2001 13:2291-2298  DOI:10.1046/j.0953-816x.2001.01609.x  PMID:11454033
• Mozzachiodi, R., Scuri, R., Roberto, M., Brunelli, M. Caulerpenyne, a toxin from the seaweed caulerpa taxifolia, depresses after hyperpolarization in invertebrate neurons Neuroscience  2001 107:519-526  DOI:10.1016/s0306-4522(01)00365-7  PMID:11719006
• Roberto, M., Brunelli, M. Pacap-38 enhances excitatory synaptic transmission in the rat hippocampal ca1 region Learning & Memory  2000 7:303-311  DOI:10.1101/lm.34200  PMID:11040262
• Brunelli, M., Garcia-Gil, M., Mozzachiodi, R., Roberto, M., Scuri, R., Traina, G., Zaccardi, M. L. Neurotoxic effects of caulerpenyne Progress in Neuro-Psychopharmacology & Biological Psychiatry  2000 24:939-954  DOI:10.1016/s0278-5846(00)00112-3  PMID:11041536