academic article

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• Yousefzadeh, M. J., Wilkinson, J. E., Hughes, B., Gadela, N., Ladiges, W. C., Vo, N., Niedernhofer, L. J., Huffman, D. M., Robbins, P. D. Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues Geroscience  2020 42:951-961  DOI:10.1007/s11357-020-00185-1  PMID:32285290  PMCID:PMC7286998
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• Gurkar, A. U., Robinson, A. R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P. D., Wang, Y., Kelley, E. E., et al. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging Redox Biology  2018 18:191-199  DOI:10.1016/j.redox.2018.06.005  PMID:30031267  PMCID:PMC6076207
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• Vo, N., Seo, H. Y., Robinson, A., Sowa, G., Bentley, D., Taylor, L., Studer, R., Usas, A., Huard, J., Alber, S., Watkins, S. C., Lee, J., et al. Accelerated aging of intervertebral discs in a mouse model of progeria Journal of Orthopaedic Research  2010 28:1600-1607  DOI:10.1002/jor.21153  PMID:20973062  PMCID:PMC3477798
• Zahid, M., Lu, X. L., Mi, Z. B., Robbins, P. D. Cationic and tissue-specific protein transduction domains: identification, characterization, and therapeutic application Advances in Genetics  2010 69:83-95  DOI:10.1016/s0065-2660(10)69007-4  PMID:20807603
• Ruffner, M. A., Robbins, P. D. Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice PLoS One  2010 5:e11848  DOI:10.1371/journal.pone.0011848  PMID:20686610  PMCID:PMC2912295
• Riedel, M. J., Gaddy, D. F., Asadi, A., Robbins, P. D., Kieffer, T. J. DsAAV8-mediated expression of glucagon-like peptide-1 in pancreatic beta-cells ameliorates streptozotocin-induced diabetes Gene Therapy  2010 17:171-180  DOI:10.1038/gt.2009.143  PMID:19865180
• Bernardini, C., Saulnier, N., Parrilla, C., Pola, E., Gambotto, A., Michetti, F., Robbins, P. D., Lattanzi, W. Early transcriptional events during osteogenic differentiation of human bone marrow stromal cells induced by Lim mineralization protein 3 Gene Expression  2010 15:27-42  DOI:10.3727/105221610x12819686555097  PMID:21061915
• Zahid, M., Phillips, B. E., Albers, S. M., Giannoukakis, N., Watkins, S. C., Robbins, P. D. Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice PLoS One  2010 5:e12252  DOI:10.1371/journal.pone.0012252  PMID:20808875  PMCID:PMC2923200
• Gaddy, D. F., Riedel, M. J., Pejawar-Gaddy, S., Kieffer, T. J., Robbins, P. D. In vivo expression of HGF/NK1 and GLP-1 from dsAAV vectors enhances pancreatic beta-cell proliferation and improves pathology in the db/db mouse model of diabetes Diabetes  2010 59:3108-3116  DOI:10.2337/db09-1886  PMID:20841608  PMCID:PMC2992772
• Tang, Y., Reay, D. P., Salay, M. N., Mi, M. Y., Clemens, P. R., Guttridge, D. C., Robbins, P. D., Huard, J., Wang, B. Inhibition of the IKK/NF-kappa B pathway by AAV gene transfer improves muscle regeneration in older mdx mice Gene Therapy  2010 17:1476-1483  DOI:10.1038/gt.2010.110  PMID:20720575  PMCID:PMC3471137
• Ghosh, H. S., McBurney, M., Robbins, P. D. SIRT1 negatively regulates the mammalian target of rapamycin PLoS One  2010 5:e9199  DOI:10.1371/journal.pone.0009199  PMID:20169165  PMCID:PMC2821410
• Reay, J., Kim, S. H., Lockhart, E., Kolls, J., Robbins, P. D. Adenoviral-mediated, intratumor gene transfer of interleukin 23 induces a therapeutic antitumor response Cancer Gene Therapy  2009 16:776-785  DOI:10.1038/cgt.2009.27  PMID:19390568  PMCID:PMC2745505
• Ruffner, M. A., Kim, S. H., Bianco, N. R., Francisco, L. M., Sharpe, A. H., Robbins, P. D. B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function European Journal of Immunology  2009 39:3084-3090  DOI:10.1002/eji.200939407  PMID:19757438  PMCID:PMC3075967
• Wehling, P., Reinecke, J., Baltzer, A. W. A., Granrath, M., Schulitz, K. P., Schultz, C., Krauspe, R., Whiteside, T. W., Elder, E., Ghivizzani, S. C., Robbins, P. D., Evans, C. H. Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis Human Gene Therapy  2009 20:97-101  DOI:10.1089/hum.2008.075  PMID:18986219  PMCID:PMC2855248
• Evans, C. H., Ghivizzani, S. C., Robbins, P. D. Gene therapy of the rheumatic diseases: 1998 to 2008 Arthritis Research & Therapy  2009 11:209  DOI:10.1186/ar2563  PMID:19232068  PMCID:PMC2688220
• Kay, J. D., Gouze, E., Oligino, T. J., Gouze, J. N., Watson, R. S., Levings, P. P., Bush, M. L., Dacanay, A., Nickerson, D. M., Robbins, P. D., Evans, C. H., Ghivizzani, S. C. Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus Journal of Gene Medicine  2009 11:605-614  DOI:10.1002/jgm.1334  PMID:19384892  PMCID:PMC2876984
• Evans, C. H., Ghivizzani, S. C., Robbins, P. D. Orthopedic gene therapy in 2008 Molecular Therapy  2009 17:231-244  DOI:10.1038/mt.2008.265  PMID:19066598  PMCID:PMC2835052
• Jeong, M., Kwon, Y. S., Park, S. H., Kim, C. Y., Jeun, S. S., Song, K. W., Ko, Y., Robbins, P. D., Billiar, T. R., Kim, B. M., Seol, D. W. Possible novel therapy for malignant gliomas with secretable trimeric TRAIL PLoS One  2009 4:e4545  DOI:10.1371/journal.pone.0004545  PMID:19229339  PMCID:PMC2641005
• Evans, C. H., Ghivizzani, S. C., Robbins, P. D. Progress and Prospects: genetic treatments for disorders of bones and joints Gene Therapy  2009 16:944-952  DOI:10.1038/gt.2009.73  PMID:19675584
• Lefevre, S., Knedla, A., Tennie, C., Kampmann, A., Wunrau, C., Dinser, R., Korb, A., Schnaker, E. M., Tarner, I. H., Robbins, P. D., Evans, C. H., Sturz, H., et al. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints Nature Medicine  2009 15:1414-20  DOI:10.1038/nm.2050  PMID:19898488  PMCID:PMC3678354
• Bianco, N. R., Kim, S. H., Ruffner, M. A., Robbins, P. D. Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models Arthritis and Rheumatism  2009 60:380-389  DOI:10.1002/art.24229  PMID:19180475  PMCID:PMC3491653
• Rehman, K. K., Trucco, M., Wang, Z., Xiao, X., Robbins, P. D. AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice Molecular Therapy  2008 16:1409-1416  DOI:10.1038/mt.2008.116  PMID:18560422  PMCID:PMC3560428
• Evans, C. H., Ghivizzani, S. C., Robbins, P. D. Arthritis gene therapy's first death Arthritis Research & Therapy  2008 10:110  DOI:10.1186/ar2411  PMID:18510784  PMCID:PMC2483436
• Moon, S. H., Nishida, K., Gilbertson, L. G., Lee, H. M., Kim, H., Hall, R. A., Robbins, P. D., Kang, J. D. Biologic response of human intervertebral disc cells to gene therapy cocktail Spine  2008 33:1850-1855  DOI:10.1097/BRS.0b013e31817e1cd7  PMID:18622355  PMCID:PMC3508786
• Sun, F., Mi, Z. B., Condliffe, S. B., Bertrand, C. A., Gong, X. Y., Lu, X. L., Zhang, R. L., Latoche, J. D., Pilewski, J. M., Robbins, P. D., Frizzell, R. A. Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia FASEB Journal  2008 22:3255-3263  DOI:10.1096/fj.07-105338  PMID:18556464  PMCID:PMC2518260
• Lattanzi, W., Parrilla, C., Fetoni, A., Logroscino, G., Straface, G., Pecorini, G., Stigliano, E., Tampieri, A., Bedini, R., Pecci, R., Michetti, F., Gambotto, A., et al. Ex vivo-transduced autologous skin fibroblasts expressing human Lim mineralization protein-3 efficiently form new bone in animal models Gene Therapy  2008 15:1330-1343  DOI:10.1038/gt.2008.116  PMID:18633445  PMCID:PMC3488859
• Montecalvo, A., Shufesky, W. J., Stolz, D. B., Sullivan, M. G., Wang, Z. L., Divito, S. J., Papworth, G. D., Watkins, S. C., Robbins, P. D., Larregina, A. T., Morelli, A. E. Exosomes as a short-range mechanism to spread alloantigen between dendiritic cells during T cell allorecognition Journal of Immunology  2008 180:3081-3090  PMID:18292531
• Yang, Q., Larsen, S. K., Mi, Z. B., Robbins, P. D., Basse, P. H. PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymes AAPS Journal  2008 10:614-621  DOI:10.1208/s12248-008-9066-z  PMID:19104945  PMCID:PMC2628208
• Ghivizzani, S. C., Gouze, E., Gouze, J. N., Kay, J. D., Bush, M. L., Watson, R. S., Levings, P. P., Nickerson, D. M., Colahan, P. T., Robbins, P. D., Evans, C. H. Perspectives on the use of gene therapy for chronic joint diseases Current Gene Therapy  2008 8:273-286  DOI:10.2174/156652308785160638  PMID:18691023
• Levicoff, E. A., Kim, J. S., Sobajima, S., Wallach, C. J., Larson, J. W., Robbins, P. D., Xiao, X., Juan, L., Vadala, G., Gilbertson, L. G., Kang, J. D. Safety assessment of intradiscal gene therapy II - effect of dosing and vector choice Spine  2008 33:1509-1516  DOI:10.1097/BRS.0b013e318178866c  PMID:18520636  PMCID:PMC3510668
• Niedemhofer, L. J., Robbins, P. D. Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan International Journal of Biochemistry & Cell Biology  2008 40:176-180  DOI:10.1016/j.biocel.2007.10.008  PMID:18023240  PMCID:PMC2192627
• Schugar, R. C., Robbins, P. D., Deasy, B. M. Small molecules in stem cell self-renewal and differentiation Gene Therapy  2008 15:126-135  DOI:10.1038/sj.gt.3303062  PMID:17989703
• Thomson, A. W., Robbins, P. D. Tolerogenic dendritic cells for autoimmune disease and transplantation Annals of the Rheumatic Diseases  2008 67:90-96  DOI:10.1136/ard.2008.099176  PMID:19022823
• Dave, S. H., Tilstra, J. S., Matsuoka, K., Li, F. L., Karrasch, T., Uno, J. K., Sepulveda, A. R., Jobin, C., Baldwin, A. S., Robbins, P. D., Plevy, S. E. Amelioration of chronic murine colitis by peptide-mediated transduction of the I kappa B kinase inhibitor NEMO binding domain peptide Journal of Immunology  2007 179:7852-7859  PMID:18025231  PMCID:PMC3203537
• Kim, S. H., Bianco, N. R., Shufesky, W. J., Morelli, A. E., Robbins, P. D. Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express il-4 Journal of Immunology  2007 179:2242-2249  PMID:17675485
• Morisset, S., Frisbie, D. D., Robbins, P. D., Nixon, A. J., McLlwraith, C. W. IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects Clinical Orthopaedics and Related Research  2007 221-228  DOI:10.1097/BLO.0b013e3180dca05f  PMID:17534189
• Rehman, K. K., Bertera, S., Trucco, M., Gambotto, A., Robbins, P. D. Immunomodulation by adenoviral-mediated SCD40-Ig gene therapy for mouse allogeneic islet transplantation Transplantation  2007 84:301-307  DOI:10.1097/01.tp.0000275183.50435.b6  PMID:17700153
• Kim, S. H., Bianco, N. R., Shufesky, W. J., Morelli, A. E., Robbins, P. D. MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner Journal of Immunology  2007 179:2235-2241  PMID:17675484
• Tilstra, J., Rehman, K. K., Hennon, T., Plevy, S. E., Clemens, P., Robbins, P. D. Protein transduction: Identification, characterization and optimization Biochemical Society Transactions  2007 35:811-815  DOI:10.1042/BST0350811  PMID:17635154
• Ghosh, H. S., Spencer, J. V., Ng, B., McBurney, M. W., Robbins, P. D. Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappa b-mediated transcription Biochemical Journal  2007 408:105-111  DOI:10.1042/bj20070817  PMID:17680780
• Goding, S., Yang, Q., Mi, Z., Robbins, P. D., Basse, P. H. Targeting of products of genes to tumor sites using adoptively transferred a-nk and t-lak cells Cancer Gene Therapy  2007 14:441-450  DOI:10.1038/sj.cgt.7701019  PMID:17273184
• Barratt-Boyes, S. M., Soloff, A. C., Gao, W. T., Nwanegbo, E., Liu, X. D., Rajakumar, P. A., Brown, K. N., Robbins, P. D., Murphey-Corb, M., Day, R. D., Gambotto, A. Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5-and 35-based vectors Journal of General Virology  2006 87:139-149  DOI:10.1099/vir.0.8.1445-0  PMID:16361426
• Kim, C. Y., Jeong, M., Mushiake, H., Kim, B. M., Kim, W. B., Ko, J. P., Kim, M. H., Kim, M., Kim, T. H., Robbins, P. D., Billiar, T. R., Seol, D. W. Cancer gene therapy using a novel secretable trimeric trail Gene Therapy  2006 13:330-338  DOI:10.1038/sj.gt.3302658  PMID:16195699
• Yurkovetsky, Z. R., Shurin, G. V., Barry, D. A., Schuh, A. C., Shurin, M. R., Robbins, P. D. Comparative analysis of antitumor activity of CD40L, RANKL, and 4-1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells Journal of Gene Medicine  2006 8:129-137  DOI:10.1002/jgm.834  PMID:16288496
• Egermann, M., Baltzer, A. W., Adamaszek, S., Evans, C., Robbins, P., Schneider, E., Lill, C. A. Direct adenoviral transfer of bone morphogenetic protein-2 cdna enhances fracture healing in osteoporotic sheep Human Gene Therapy  2006 17:507-517  DOI:10.1089/hum.2006.17.507  PMID:16716108
• Goodrich, L. R., D Brower-Toland, B., Warnick, L., Robbins, P. D., Evans, C. H., Nixon, A. J. Direct adenovirus-mediated IGF-l gene transduction of synovium induces persisting synovial fluid IGF-l ligand elevations Gene Therapy  2006 13:1253-1262  DOI:10.1038/sj.gt.3302757  PMID:16708081
• Egermann, M., Lill, C. A., Griesbeck, K., Evans, C. H., Robbins, P. D., Schneider, E., Baltzer, A. W. Effect of bmp-2 gene transfer on bone healing in sheep Gene Therapy  2006 13:1290-1299  DOI:10.1038/sj.gt.3302785  PMID:16642029
• Kim, S. H., Bianco, N., Menon, R., Lechman, E. R., Shufesky, W. J., Morelli, A. E., Robbins, P. D. Exosomes derived from genetically modified dc expressing fasl are anti-inflammatory and immunosuppressive Molecular Therapy  2006 13:289-300  DOI:10.1016/j.ymthe.2005.09.015  PMID:16275099
• Miyamae, T., Marinov, A. D., Sowders, D., Wilson, D. C., Devlin, J., Boudreau, R., Robbins, P., Hirsch, R. Follistatin-like protein-1 is a novel proinflammatory molecule Journal of Immunology  2006 177:4758-4762  PMID:16982916
• Evans, C. H., Gouze, E., Gouze, J. N., Robbins, P. D., Ghivizzani, S. C. Gene therapeutic approaches-transfer in vivo Advanced Drug Delivery Reviews  2006 58:243-258  DOI:10.1016/j.addr.2006.01.009  PMID:16563557
• Evans, C. H., Ghivizzani, S. C., Robbins, P. D. Gene therapy for arthritis - what next? Arthritis and Rheumatism  2006 54:1714-1729  DOI:10.1002/art.21886  PMID:16729280
• Keravala, A., Lechman, E. R., Nash, J., Mi, Z. B., Robbins, P. D. Human, viral or mutant human il-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis Arthritis Research & Therapy  2006 8:R91  DOI:10.1186/ar1960  PMID:16704745  PMCID:PMC1779418
• Keravala, A., Liu, D. X., Lechman, E. R., Wolfe, D., Nash, J. A., Lampe, D. J., Robbins, P. D. Hyperactive Himar1 transposase mediates transposition in cell culture and enhances gene expression in vivo Human Gene Therapy  2006 17:1006-1018  DOI:10.1089/hum.2006.17.1006  PMID:16989604
• Yao, Q. P., Seol, D. W., Mi, Z. B., Robbins, P. D. Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis Arthritis Research & Therapy  2006 8:R16  DOI:10.1186/ar1867  PMID:16507116  PMCID:PMC1526576
• Keravala, A., Portlock, J. L., Nash, J. A., Vitrant, D. G., Robbins, P. D., Calos, M. P. Phic31 integrase mediates integration in cultured synovial cells and enhances gene expression in rabbit joints Journal of Gene Medicine  2006 8:1008-1017  DOI:10.1002/jgm.928  PMID:16779871
• Gao, W. T., Soloff, A. C., Lu, X. H., Montecalvo, A., Nguyen, D. C., Matsuoka, Y., Robbins, P. D., Swayne, D. E., Donis, R. O., Katz, J. M., Barratt-Boyes, S. M., Gambotto, A. Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization Journal of Virology  2006 80:1959-1964  DOI:10.1128/jvi.80.4.1959-1964.2006  PMID:16439551
• Wang, Z., Zhu, T., Rehman, K. K., Bertera, S., Zhang, J., Chen, C. L., Papworth, G., Watkins, S., Trucco, M., Robbins, P. D., Li, J., Xiao, X. Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes Diabetes  2006 55:875-884  DOI:10.2337/diabetes.55.04.06.db05-0927  PMID:16567506
• Kawamura, K., Chu, C. R., Sobajima, S., Robbins, P. D., Fu, F. H., Izzo, N. J., Niyibizi, C. Adenoviral-mediated transfer of tgf-beta 1 but not igf-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures Experimental Hematology  2005 33:865-872  DOI:10.1016/j.exphem.2005.05.010  PMID:16038778  PMCID:PMC1360180
• Mahidhara, R. S., De Oliveira, P. E. Q., Kohout, J., Beer, D. G., Lin, J. Y., Watkins, S. C., Robbins, P. D., Hughes, S. J. Altered trafficking of FAS and subsequent resistance to FAS-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma Journal of Surgical Research  2005 123:302-311  DOI:10.1016/j.jss.2004.08.016  PMID:15680394
• Haupt, J. L., Frisbie, D. D., McIlwraith, C. W., Robbins, P. D., Ghivizzani, S., Evans, C. H., Nixon, A. J. Dual transduction of insulin-like growth factor-l and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model Journal of Orthopaedic Research  2005 23:118-126  DOI:10.1016/j.orthres.2004.06.020  PMID:15607883
• Rehman, K. K., Wang, Z., Bottino, R., Balamurugan, A. N., Trucco, M., Li, J., Xiao, X., Robbins, P. D. Efficient gene delivery to human and rodent islets with double-stranded (ds) aav-based vectors Gene Therapy  2005 12:1313-1323  DOI:10.1038/sj.gt.3302530  PMID:15858610
• Kim, S. H., Lechman, E. R., Bianco, N., Menon, R., Keravala, A., Nash, J., Mi, Z. B., Watkins, S. C., Gambotto, A., Robbins, P. D. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis Journal of Immunology  2005 174:6440-6448  PMID:15879146
• Evans, C. H., Ghivizziani, S. C., Herndon, J. H., Robbins, P. D. Gene therapy for the treatment of musculoskeletal diseases Journal of the American Academy of Orthopaedic Surgeons  2005 13:230-242  PMID:16112980
• Evans, C. H., Robbins, P. D., Ghivizzani, S. C., Wasko, M. C., Tomaino, M. M., Kang, R., Muzzonigro, T. A., Vogt, M., Elder, E. M., Whiteside, T. L., Watkins, S. C., Herndon, J. H. Gene transfer to human joints: progress toward a gene therapy of arthritis Proceedings of the National Academy of Sciences of the United States of America  2005 102:8698-8703  DOI:10.1073/pnas.0502854102  PMID:15939878  PMCID:PMC1150836
• Nixon, A. J., Haupt, J. L., Frisbie, D. D., Morisset, S. S., McIlwraith, C. W., Robbins, P. D., Evans, C. H., Ghivizzani, S. Gene-mediated restoration of cartilage matrix by combination insulin-like growth factor-l/interleukin-1 receptor antagonist therapy Gene Therapy  2005 12:177-186  DOI:10.1038/sj.gt.3302396  PMID:15578043
• Yang, S. Y., Nasser, S., Markel, D. C., Robbins, P. D., Wooley, P. H. Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor Journal of Bone and Joint Surgery-American Volume  2005 87A:1088-1097  DOI:10.2106/jbjs.d.02052  PMID:15866974
• He, Y. K., Zhang, J. Y., Mi, Z. B., Robbins, P., Falo, L. D. Immunization with lentiviral vector-transduced dendritic cells induces strong and long-lasting T cell responses and therapeutic immunity Journal of Immunology  2005 174:3808-3817  PMID:15749922
• Feeley, B. T., Gamradt, S. C., Hsu, W. K., Liu, N., Krenek, L., Robbins, P., Huard, J., Lieberman, J. R. Influence of BMPs on the formation of osteoblastic lesions in metastatic prostate cancer Journal of Bone and Mineral Research  2005 20:2189-2199  DOI:10.1359/jbmr.050802  PMID:16294272
• Koch, H., Jadlowiec, J. A., Whalen, J. D., Robbins, P., Lattermann, C., Fu, F. H., Merk, H. R., Hollinger, J. O. Osteoblastic differentiation of human adult mesenchymal stem cells after through gene transfer of BMP-2 in the absence of dexamethasone Zeitschrift für Orthopadie und Ihre Grenzgebiete  2005 143:684-690  DOI:10.1055/s-2005-918186  PMID:16380902
• Koch, H., Jadlowiec, J. A., Whalen, J. D., Lattermann, C., Robbins, P., Fu, F. H., Merk, H., Hollinger, J. O. Refined adenoviral transduction for controlled gene transfer into human adult mesenchymal stem cells Zeitschrift für Orthopadie und Ihre Grenzgebiete  2005 143:677-683  DOI:10.1055/s-2005-872526  PMID:16380901
• Evans, C. H., Ghivizzani, S. C., Gouze, E., Rediske, J. J., Schwarz, E. M., Robbins, P. D. The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics Arthritis Research & Therapy  2005 7:273-278  DOI:10.1186/ar1853  PMID:16277703  PMCID:PMC1297596
• Lattermann, C., Oxner, W. M., Xiao, X., Li, J., Gilbertson, L. G., Robbins, P. D., Kang, J. D. The adeno associated viral vector as a strategy for intradiscal gene transfer in immune competent and pre-exposed rabbits Spine  2005 30:497-504  DOI:10.1097/01.brs.0000154764.62072.44  PMID:15738780
• Mukherjee, P., Yang, S. Y., Wu, B., Song, Z., Myers, L. K., Robbins, P. D., Wooley, P. H. Tumour necrosis factor receptor gene therapy affects cellular immune responses in collagen induced arthritis in mice Annals of the Rheumatic Diseases  2005 64:1550-1556  DOI:10.1136/ard.2004.025619  PMID:15860512  PMCID:PMC1755256
• Balkir, L., Tourkova, I. L., Makarenkova, V. P., Shurin, G. V., Robbins, P. D., Yin, X. M., Chatta, G., Shurin, M. R. Comparative analysis of dendritic cells transduced with different anti-apoptotic molecules: sensitivity to tumor-induced apoptosis Journal of Gene Medicine  2004 6:537-544  DOI:10.1002/jgm.545  PMID:15133764
• Pola, E., Gao, W., Zhou, Y., Pola, R., Lattanzi, W., Sfeir, C., Gambotto, A., Robbins, P. Efficient bone formation by gene transfer of human LIM mineralization protein-3 Gene Therapy  2004 11:683-693  DOI:10.1038/sj.gt.3302207  PMID:14724674
• Shen, H. M., Mai, J. C., Qiu, L., Cao, S. N., Robbins, P. D., Cheng, T. Evaluation of peptide-mediated transduction in human CD34(+) cells Human Gene Therapy  2004 15:415-419  DOI:10.1089/104303404322959560  PMID:15053866
• Stewart, M. C., Kadlcek, R. M., Robbins, P. D., Macleod, J. N., Ballock, R. T. Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation Journal of Bone and Mineral Research  2004 19:123-132  DOI:10.1359/jbmr.0301209  PMID:14753744
• Lattermann, C., Baltzer, A. W., Zelle, B. A., Whalen, J. D., Niyibizi, C., Robbins, P. D., Evans, C. H., Gruen, G. S. Feasibility of percutaneous gene transfer to an atrophic nonunion in a rabbit Clinical Orthopaedics and Related Research  2004 237-243  DOI:10.1097/blo.0000137292.25504.22  PMID:15292814
• Bertera, S., Alexander, A. M., Crawford, M. L., Papworth, G., Watkins, S. C., Robbins, P. D., Trucco, M. Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans Experimental Diabesity Research  2004 5:201-210  DOI:10.1080/15438600490486822  PMID:15512788  PMCID:PMC2478630
• Pascher, A., Palmer, G. D., Steinert, A., Oligino, T., Gouze, E., Gouze, J. N., Betz, O., Spector, M., Robbins, P. D., Evans, C. H., Ghivizzani, S. C. Gene delivery to cartilage defects using coagulated bone marrow aspirate Gene Therapy  2004 11:133-141  DOI:10.1038/sj.gt.3302155  PMID:14712297
• Niyibizi, C., Wang, S., Mi, Z., Robbins, P. D. Gene therapy approaches for osteogenesis imperfecta Gene Therapy  2004 11:408-416  DOI:10.1038/sj.gt.3302199  PMID:14724682
• Lattermann, C., Zelle, B. A., Whalen, J. D., Baltzer, A. W. A., Robbins, P. D., Niyibizi, C., Evans, C. H., Fu, F. H. Gene transfer to the tendon-bone insertion site Knee Surgery Sports Traumatology Arthroscopy  2004 12:510-515  DOI:10.1007/s00167-003-0482-4  PMID:15014945
• Evans, C. H., Gouze, J. N., Gouze, E., Robbins, P. D., Ghivizzani, S. C. Osteoarthritis gene therapy Gene Therapy  2004 11:379-389  DOI:10.1038/sj.gt.3302196  PMID:14724685
• Nwanegbo, E., Vardas, E., Gao, W. T., Whittle, H., Sun, H. J., Rowe, D., Robbins, P. D., Gambotto, A. Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of the Gambia, South Africa, and the United States Clinical and Diagnostic Laboratory Immunology  2004 11:351-357  DOI:10.1128/cdli.11.2.351-357.2004  PMID:15013987
• Machen, J., Bertera, S., Chang, Y., Bottino, R., Balamurugan, A. N., Robbins, P. D., Trucco, M., Giannoukakis, N. Prolongation of islet allograft survival following ex vivo transduction with adenovirus encoding a soluble type 1 TNF receptor-lg fusion decoy Gene Therapy  2004 11:1506-1514  DOI:10.1038/sj.gt.3302320  PMID:15229635
• Yang, S. Y., Wu, B., Mayton, L., Mukherjee, P., Robbins, P. D., Evans, C. H., Wooley, P. H. Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis Gene Therapy  2004 11:483-491  DOI:10.1038/sj.gt.3302192  PMID:14724688
• Evans, C. H., Ghivizzani, S. C., Robbins, P. D. The 2003 Nicolas Andry Award: Orthopaedic gene therapy Clinical Orthopaedics and Related Research  2004 316-329  DOI:10.1097/01.blo.0000148854.14399.ec  PMID:15577504
• Niyibizi, C., Wang, S. J., Mi, Z. B., Robbins, P. D. The fate of mesenchymal stem cells transplanted into immunocompetent neonatal mice: implications for skeletal gene therapy via stem cells Molecular Therapy  2004 9:955-963  DOI:10.1016/j.ymthe.2004.02.022  PMID:15194062
• Gao, W. T., Rzewski, A., Sun, H. J., Robbins, P. D., Gambotto, A. Upgene: Application of a web-based DNA codon optimization algorithm Biotechnology Progress  2004 20:443-448  DOI:10.1021/bp0300467  PMID:15058988
• Kitagawa, T., Iwazawa, T., Robbins, P. D., Lotze, M. T., Tahara, H. Advantages and limitations of particle-mediated transfection (gene gun) in cancer immuno-gene therapy using IL-10, IL-12 or B7-1 in murine tumor models Journal of Gene Medicine  2003 5:958-965  DOI:10.1002/jgm.441  PMID:14601133
• Mi, Z., Ghivizzani, S. C., Lechman, E., Glorioso, J. C., Evans, C. H., Robbins, P. D. Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees Arthritis Research & Therapy  2003 5:R132-R139  DOI:10.1186/ar745  PMID:12723985  PMCID:PMC165041
• Kaneko, K., Wang, Z., Kim, S. H., Morelli, A. E., Robbins, P. D., Thomson, A. W. Dendritic cells genetically engineered to express IL-4 exhibit enhanced IL-12p70 production in response to CD40 ligation and accelerate organ allograft rejection Gene Therapy  2003 10:143-152  DOI:10.1038/sj.gt.3301872  PMID:12571643
• Feili-Hariri, M., Falkner, D. H., Gambotto, A., Papworth, G. D., Watkins, S. C., Robbins, P. D., Morel, P. A. Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis Human Gene Therapy  2003 14:13-23  DOI:10.1089/10430340360464679  PMID:12573055
• Nishioka, Y., Wen, H., Mitani, K., Robbins, P. D., Lotze, M. T., Sone, S., Tahara, H. Differential effects of il-12 on the generation of alloreactive ctl mediated by murine and human dendritic cells: A critical role for nitric oxide Journal of Leukocyte Biology  2003 73:621-629  DOI:10.1189/jlb.0402205  PMID:12714577
• Gao, W. T., Tamin, A., Soloff, A., D'Aiuto, L., Nwanegbo, E., Robbins, P. D., Bellini, W. J., Barratt-Boyes, S., Gambotto, A. Effects of a SARS-associated coronavirus vaccine in monkeys Lancet  2003 362:1895-1896  DOI:10.1016/s0140-6736(03)14962-8  PMID:14667748
• Witham, T. F., Villa, L., Yang, T. B., Pollack, I. F., Okada, H., Robbins, P. D., Chambers, W. H. Expression of a soluble transforming growth factor-beta (TGF beta) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivo Journal of Neuro-Oncology  2003 64:63-69  DOI:10.1007/bf02700021  PMID:12952287
• Robbins, P. D., Evans, C. H., Chernajovsky, Y. Gene therapy for arthritis Gene Therapy  2003 10:902-911  DOI:10.1038/sj.gt.3302040  PMID:12732875
• Bertera, S., Crawford, M. L., Alexander, A. M., Papworth, G. D., Watkins, S. C., Robbins, P. D., Trucco, M. Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes Diabetes  2003 52:387-393  PMID:12540612
• Wallach, C. J., Sobajima, S., Watanabe, Y., Kim, J. S., Georgescu, H. I., Robbins, P., Gilbertson, L. G., Kang, J. D. Gene transfer of the catabolic inhibitor TIMP-1 increases measured proteoglycans in cells from degenerated human intervertebral discs Spine  2003 28:2331-2337  DOI:10.1097/01.brs.0000085303.67942.94  PMID:14560079
• Gao, W., Robbins, P. D., Gambotto, A. Human adenovirus type 35: nucleotide sequence and vector development Gene Therapy  2003 10:1941-1949  DOI:10.1038/sj.gt.3302097  PMID:14528318
• Mi, Z. B., Lu, X. L., Mai, J. C., Bobby, G. N., Wang, G. Q., Lechman, E. R., Watkins, S. C., Rabinowich, H., Robbins, P. D. Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium Molecular Therapy  2003 8:295-305  DOI:10.1016/s1525-016(03)00181-3  PMID:12907152
• Gao, W. T., Kumar, S., Lotze, M. T., Hanning, C., Robbins, P. D., Gambotto, A. Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity Journal of Immunology  2003 170:107-113  PMID:12496389
• Numasaki, M., Fukushi, J., Ono, M., Narula, S. K., Zavodny, P. J., Kudo, T., Robbins, P. D., Tahara, H., Lotze, M. T. Interleukin-17 promotes angiogenesis and tumor growth Blood  2003 101:2620-2627  DOI:10.1182/blood-2002-05-1461  PMID:12411307
• Yao, Q., Wang, S., Gambotto, A., Glorioso, J. C., Evans, C. H., Robbins, P. D., Ghivizzani, S. C., Oligino, T. J. Intra-articular adenoviral-mediated gene transfer of trail induces apoptosis of arthritic rabbit synovium Gene Therapy  2003 10:1055-1060  DOI:10.1038/sj.gt.3301881  PMID:12776164
• Tatsumi, T., Huang, J., Gooding, W. E., Gambotto, A., Robbins, P. D., Vujanovic, N. L., Alber, S. M., Watkins, S. C., Okada, H., Storkus, W. J. Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity Cancer Research  2003 63:6378-6386  PMID:14559827
• Hashimoto, W., Tanaka, F., Robbins, P. D., Taniguchi, M., Okamura, H., Lotze, M. T., Tahara, H. Natural killer, but not natural killer T, cells play a necessary role in the promotion of an innate antitumor response induced by IL-18 International Journal of Cancer  2003 103:508-513  DOI:10.1002/ijc.10844  PMID:12478667
• Jiang, J. F., Serinkan, B. F., Tyurina, Y. Y., Borisenko, G. G., Mi, Z. B., Robbins, P. D., Schroit, A. J., Kagan, V. E. Peroxidation and externalization of phosphatidylserine associated with release of cytochrome c from mitochondria Free Radical Biology and Medicine  2003 35:814-825  DOI:10.1016/s0891-5849(03)00429-5  PMID:14583346
• Ma, L. L., Qian, S. G., Liang, X. Y., Wang, L. F., Woodward, J. E., Giannoukakis, N., Robbins, P. D., Bertera, S., Trucco, M., Fung, J. J., Lu, L. Prevention of diabetes in NOD nice by administration of dendritic cells deficient in nuclear transcription factor-kappa B activity Diabetes  2003 52:1976-1985  DOI:10.2337/diabetes.52.8.1976  PMID:12882913
• Rehman, K. K., Bertera, S., Bottino, R., Balamurugan, A. N., Mai, J. C., Mi, Z. B., Trucco, M., Robbins, P. D. Protection of islets by in situ peptide-mediated transduction of the I kappa B kinase inhibitor nemo-binding domain peptide Journal of Biological Chemistry  2003 278:9862-9868  DOI:10.1074/jbc.M207700200  PMID:12524423
• Gruss, C. J., Satyamoorthy, K., Berking, C., Lininger, J., Nesbit, M., Schaider, H., Liu, Z. J., Oka, M., Hsu, M. Y., Shirakawa, T., Li, G., Bogenrieder, T., et al. Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice Journal of Investigative Dermatology  2003 120:683-692  DOI:10.1046/j.1523-1747.2003.12112.x  PMID:12648235
• Leong, P. L., Andrews, G. A., Johnson, D. E., Dyer, K. F., Xi, S. C., Mai, J. C., Robbins, P. D., Gadiparthi, S., Burke, N. A., Watkins, S. F., Grandis, J. R. Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth Proceedings of the National Academy of Sciences of the United States of America  2003 100:4138-4143  DOI:10.1073/pnas.0534764100  PMID:12640143  PMCID:PMC153061
• Lechman, E. R., Keravala, A., Nash, J., Kim, S. H., Mi, Z., Robbins, P. D. The contralateral effect conferred by intra-articular adenovirus-mediated gene transfer of viral IL-10 is specific to the immunizing antigen Gene Therapy  2003 10:2029-2035  DOI:10.1038/sj.gt.3302109  PMID:14566362
• Geng, X. H., Li, L. H., Watkins, S., Robbins, P. D., Drain, P. The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas Diabetes  2003 52:767-776  DOI:10.2337/diabetes.52.3.767  PMID:12606519
• Hitchens, M. R., Robbins, P. D. The role of the transcription factor dp in apoptosis Apoptosis  2003 8:461-468  DOI:10.1023/a:1025586207239  PMID:12975577
• Mukherjee, P., Wu, B., Mayton, L., Kim, S. H., Robbins, P. D., Wooley, P. H. Tnf receptor gene therapy results in suppression of igg2a anticollagen antibody in collagen induced arthritis Annals of the Rheumatic Diseases  2003 62:707-714  DOI:10.1136/ard.62.8.707  PMID:12860724  PMCID:PMC1754640
• Niyibizi, C., Wallach, C. J., Mi, Z. B., Robbins, P. D. Approaches for skeletal gene therapy Critical Reviews in Eukaryotic Gene Expression  2002 12:163-173  DOI:10.1615/CritRevEukaryotGeneExpr.v12.i3.10  PMID:12449341
• Palmer, G., Pascher, A., Gouze, E., Gouze, J. N., Betz, O., Spector, M., Robbins, P. D., Evans, C. H., Ghivizzani, S. C. Development of gene-based therapies for cartilage repair Critical Reviews in Eukaryotic Gene Expression  2002 12:259-273  DOI:10.1615/CritRevEukaryotGeneExpr.v12.i4.20  PMID:12641395
• Kim, S. H., Kim, S., Oligino, T. J., Robbins, P. D. Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL Molecular Therapy  2002 6:584-590  DOI:10.1006/mthe.2002.0712  PMID:12409256
• Mai, J. C., Shen, H. M., Watkins, S. C., Cheng, T., Robbins, P. D. Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate Journal of Biological Chemistry  2002 277:30208-30218  DOI:10.1074/jbc.M204202200  PMID:12034749
• Lee, J. Y., Peng, H. R., Usas, A., Musgrave, D., Cummins, J., Pelinkovic, D., Jankowski, R., Ziran, B., Robbins, P., Huard, J. Enhancement of bone healing based on ex vivo gene therapy using human muscle-derived cells expressing bone morphogenetic protein 2 Human Gene Therapy  2002 13:1201-1211  DOI:10.1089/104303402320138989  PMID:12133273
• Kim, S. H., Lechman, E. R., Kim, S., Nash, J., Oligino, T. J., Robbins, P. D. Ex vivo gene delivery of il-1ra and soluble tnf receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis Molecular Therapy  2002 6:591-600  DOI:10.1006/mthe.2002.0711  PMID:12409257
• Giannoukakis, N., Robbins, P. D. Gene and cell therapies for diabetes mellitus - strategies and clinical potential BioDrugs  2002 16:149-173  DOI:10.2165/00063030-200216030-00001  PMID:12102644
• Martinek, V., Usas, A., Pelinkovic, D., Robbins, P., Fu, F. H., Huard, J. Genetic engineering of meniscal allografts Tissue Engineering  2002 8:107-117  DOI:10.1089/107632702753503108  PMID:11886659
• Yang, S., Wu, B., Mayton, L., Evans, C. H., Robbins, P. D., Wooley, P. H. IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model Inflammation Research  2002 51:342-350  DOI:10.1007/pl00000313  PMID:12146725
• Watkins, S., Geng, X. H., Li, L. H., Papworth, G., Robbins, P. D., Drain, P. Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide Traffic  2002 3:461-471  DOI:10.1034/j.1600-0854.2002.30703.x  PMID:12047554
• Ma, L. L., Rudert, W. A., Harnaha, J., Wright, M., Machen, J., Lakomy, R., Qian, S. G., Lu, L. N., Robbins, P. D., Trucco, M., Giannoukakis, N. Immunosuppressive effects of glucosamine Journal of Biological Chemistry  2002 277:39343-39349  DOI:10.1074/jbc.M204924200  PMID:12176986
• Tourkova, I. L., Yurkovetsky, Z. R., Gambotto, A., Makarenkova, V. P., Perez, L., Balkir, L., Robbins, P. D., Shurin, M. R., Shurin, G. V. Increased function and survival of IL-15-transduced human dendritic cells are mediated by up-regulation of IL-15R alpha and Bcl-2 Journal of Leukocyte Biology  2002 72:1037-1045  PMID:12429727
• Alexander, A. M., Crawford, M., Bertera, S., Rudert, W. A., Takikawa, O., Robbins, P. D., Trucco, M. Indoleamine 2,3-dioxygenase expression in trans-planted NOD islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes Diabetes  2002 51:356-365  PMID:11812742
• Neumann, E., Judex, M., Kullmann, F., Grifka, J., Robbins, P. D., Pap, T., Gay, R. E., Evans, C. H., Gay, S., Scholmerich, J., Muller-Ladner, U. Inhibition of cartilage destruction by double gene transfer of IL-1Ra and IL-10 involves the activin pathway Gene Therapy  2002 9:1508-1519  DOI:10.1038/sj.gt.3301811  PMID:12407423
• Tatsumi, T., Gambotto, A., Robbins, P. D., Storkus, W. J. Interleukin 18 gene transfer expands the repertoire of antitumor Th1-type immunity elicited by dendritic cell-based vaccines in association with enhanced therapeutic efficacy Cancer Research  2002 62:5853-5858  PMID:12384548
• Bonham, C. A., Peng, L. S., Liang, X. Y., Chen, Z. Y., Wang, L. F., Ma, L. L., Hackstein, H., Robbins, P. D., Thomson, A. W., Fung, J. J., Qian, S. G., Lu, L. Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-lg Journal of Immunology  2002 169:3382-3391  PMID:12218160
• Lee, C. W., Martinek, V., Usas, A., Musgrave, D., Pickvance, E. A., Robbins, P., Moreland, M. S., Fu, F. H., Huard, J. Muscle-based gene therapy and tissue engineering for treatment of growth plate injuries Journal of Pediatric Orthopaedics  2002 22:565-572  DOI:10.1097/01.bpo.0000026337.10173.bd  PMID:12198455
• Ma, Z., Mi, Z., Wilson, A., Alber, S., Robbins, P. D., Watkins, S., Pitt, B., Li, S. Redirecting adenovirus to pulmonary endothelium by cationic liposomes Gene Therapy  2002 9:176-182  DOI:10.1038/sj/gt/3301636  PMID:11859420
• Tanaka, F., Hashimoto, W., Robbins, P. D., Lotze, M. T., Tahara, H. Therapeutic and specific antitumor immunity induced by co-administration of immature dendritic cells and adenoviral vector expressing biologically active IL-18 Gene Therapy  2002 9:1480-1486  DOI:10.1038/sj.gt.3301827  PMID:12378411
• Frisbie, D. D., Ghivizzani, S. C., Robbins, P. D., Evans, C. H., McIlwraith, C. W. Treatment of experimental equine osteoarthritis by in vivo delivery of the equine interleukin-1 receptor antagonist gene Gene Therapy  2002 9:12-20  DOI:10.1038/sj.gt.3301608  PMID:11850718
• Srinivasula, S. M., Hegde, R., Saleh, A., Datta, P., Shiozaki, E., Chai, J. J., Lee, R. A., Robbins, P. D., Fernandes-Alnemri, T., Shi, Y. G., Alnemri, E. S. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis Nature  2001 410:112-116  DOI:10.1038/35065125  PMID:11242052
• Mai, J. C., Mi, Z. B., Kim, S. H., Ng, B., Robbins, P. D. A proapoptotic peptide for the treatment of solid tumors Cancer Research  2001 61:7709-7712  PMID:11691780
• Del Vecchio, M. A., Georgescu, H. I., McCormack, J. E., Robbins, P. D., Evans, C. H. Approaches to enhancing the retroviral transduction of human synoviocytes Arthritis Research  2001 3:259-263  DOI:10.1186/ar311  PMID:11438045  PMCID:PMC34116
• Lu, C. X., Schwartzbauer, G., Sperling, M. A., Devaskar, S. U., Thamotharan, S., Robbins, P. D., McTiernan, C. F., Liu, J. L., Jiang, J., Frank, S. J., Menon, R. K. Demonstration of direct effects of growth hormone on neonatal cardiomyocytes Journal of Biological Chemistry  2001 276:22892-22900  DOI:10.1074/jbc.M011647200  PMID:11303022
• Li, Y. Y., Mi, Z. B., Feng, Y. Q., McTiernan, C. F., Zhou, R. P., Robbins, P. D., Watkins, S. C., Feldman, A. M. Differential effects of overexpression of two forms of ephrin-A5 on neonatal rat cardiomyocytes American Journal of Physiology-Heart and Circulatory Physiology  2001 281:H2738-H2746  PMID:11709443
• Brower-Toland, B. D., Saxer, R. A., Goodrich, L. R., Mi, Z. B., Robbins, P. D., Evans, C. H., Nixon, A. J. Direct adenovirus-mediated insulin-like growth factor i gene transfer enhances transplant chondrocyte function Human Gene Therapy  2001 12:117-129  DOI:10.1089/104303401750061186  PMID:11177549
• Ghivizzani, S. C., Oligino, T. J., Glorioso, J. C., Robbins, P. D., Evans, C. H. Direct gene delivery strategies for the treatment of rheumatoid arthritis Drug Discovery Today  2001 6:259-267  DOI:10.1016/s1359-6446(01)01685-3  PMID:11182599
• Lee, J. Y., Musgrave, D., Pelinkovic, D., Fukushima, K., Cummins, J., Usas, A., Robbins, P., Fu, F. H., Huard, J. Effect of bone morphogenetic protein-2-expressing muscle-derived cells on healing of critical-sized bone defects in mice Journal of Bone and Joint Surgery-American Volume  2001 83A:1032-1039  PMID:11451972
• Kim, S. H., Kim, S., Evans, C. H., Ghivizzani, S. C., Oligino, T., Robbins, P. D. Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4 Journal of Immunology  2001 166:3499-3505  PMID:11207309
• Sud, S., Yang, S. Y., Evans, C. H., Robbins, P. D., Wooley, P. H. Effects of cytokine gene therapy on particulate-induced inflammation in the murine air pouch Inflammation  2001 25:361-372  DOI:10.1023/a:1012898513512  PMID:11831439
• Kadokami, T., McTiernan, C. F., Kubota, T., Frye, C. S., Bounoutas, G. S., Robbins, P. D., Watkins, S. C., Feldman, A. M. Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expression American Journal of Physiology-Heart and Circulatory Physiology  2001 280:H2281-H2291  PMID:11299232
• Saxer, R. A., Bent, S. J., Brower-Toland, B. D., Mi, Z. B., Robbins, P. D., Evans, C. H., Nixon, A. J. Gene mediated insulin-like growth factor-i delivery to the synovium Journal of Orthopaedic Research  2001 19:759-767  DOI:10.1016/s0736-0266(00)00077-2  PMID:11562119
• Baltzer, A. W. A., Whalen, J. D., Wooley, P., Latterman, C., Truchan, L. M., Robbins, P. D., Evans, C. H. Gene therapy for osteoporosis: Evaluation in a murine ovariectomy model Gene Therapy  2001 8:1770-1776  DOI:10.1038/sj.gt.3301594  PMID:11803396
• Yao, Q. P., Wang, S. J., Glorioso, J. C., Evans, C. H., Robbins, P. D., Ghivizzani, S. C., Oligino, T. J. Gene transfer of p53 to arthritic joints stimulates synovial apoptosis and inhibits inflammation Molecular Therapy  2001 3:901-910  DOI:10.1006/mthe.2001.0343  PMID:11407904
• Wolfe, D., Goins, W. F., Kaplan, T. J., Capuano, S. V., Fradette, J., Murphey-Corb, M., Robbins, P. D., Cohen, J. B., Glorioso, J. C. Herpesvirus-mediated systemic delivery of nerve growth factor Molecular Therapy  2001 3:61-69  DOI:10.1006/mthe.2000.0225  PMID:11162312
• Kang, W. K., Park, C., Yoon, H. L., Kim, W. S., Yoon, S. S., Lee, M. H., Park, K., Kim, K., Jeong, H. S., Kim, J. A., Nam, S. J., Yang, J. H., et al. Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: Outcome of a phase I study Human Gene Therapy  2001 12:671-684  DOI:10.1089/104303401300057388  PMID:11426466
• Iwazawa, T., Chau, G. Y., Mori, T., Dookeran, K. A., Rubin, J. T., Watkins, S., Robbins, P. D., Lotze, M. T., Tahara, H. Potent antitumor effects of intra-arterial injection of fibroblasts genetically engineered to express IL-12 in liver metastasis model of rat: No additional benefit of using retroviral producer cell Cancer Gene Therapy  2001 8:17-22  PMID:11219489
• Musgrave, D. S., Pruchnic, R., Wright, V., Bosch, P., Ghivizzani, S. C., Robbins, P. D., Huard, J. The effect of bone morphogenetic protein-2 expression on the early fate of skeletal muscle-derived cells Bone  2001 28:499-506  DOI:10.1016/s8756-3282(01)00413-6  PMID:11344049
• Niyibizi, C., Smith, P., Mi, Z. B., Phillips, C. L., Robbins, P. Transfer of pro alpha 2(i) cdna into cells of a murine model of human osteogenesis imperfecta restores synthesis of type i collagen comprised of alpha 1(i) and alpha 2(i) heterotrimers in vitro and in vivo Journal of Cellular Biochemistry  2001 83:84-91  DOI:10.1002/jcb.1209  PMID:11500956
• Berking, C., Takemoto, R., Schaider, H., Showe, L., Satyamoorthy, K., Robbins, P., Herlyn, M. Transforming growth factor-beta 1 increases survival of human melanoma through stroma remodeling Cancer Research  2001 61:8306-8316  PMID:11719464
• Whalen, J. D., Thomson, A. W., Lu, L., Robbins, P. D., Evans, C. H. Viral IL-10 gene transfer inhibits DTH responses to soluble antigens: Evidence for involvement of genetically modified dendritic cells and macrophages Molecular Therapy  2001 4:543-550  DOI:10.1006/mthe.2001.0492  PMID:11735338
• Yao, Q. P., Glorioso, J. C., Evans, C. H., Robbins, P. D., Kovesdi, I., Oligino, T. J., Ghivizzani, S. C. Adenoviral mediated delivery of FAS ligand to arthritic joints causes extensive apoptosis in the synovial lining Journal of Gene Medicine  2000 2:210-219  DOI:10.1002/(sici)1521-2254(200005/06)2:3<210::aid-jgm101>3.0.co;2-p  PMID:10894267
• Mi, Z. B., Ghivizzani, S. C., Lechman, E. R., Jaffurs, D., Glorioso, J. C., Evans, C. H., Robbins, P. D. Adenovirus-mediated gene transfer of insulin-like growth factor 1 stimulates proteoglycan synthesis in rabbit joints Arthritis and Rheumatism  2000 43:2563-2570  DOI:10.1002/1529-0131(200011)43:11<2563::aid-anr25>3.0.co;2-8  PMID:11083281
• Hirao, M., Onai, N., Hiroishi, K., Watkins, S. C., Matsushima, K., Robbins, P. D., Lotze, M. T., Tahara, H. Cc chemokine receptor-7 on dendritic cells is induced after interaction with apoptotic tumor cells: Critical role in migration from the tumor site to draining lymph nodes Cancer Research  2000 60:2209-2217  PMID:10786686
• Mi, Z. B., Mai, J., Lu, X. L., Robbins, P. D. Characterization of a class of cationic peptides able to facilitate efficient protein transduction in vitro and in vivo Molecular Therapy  2000 2:339-347  DOI:10.1006/mthe.2000.0137  PMID:11020349
• Evans, C. H., Ghivizzani, S. C., Herndon, J. H., Wasko, M. C., Reinecke, J., Wehling, P., Robbins, P. D. Clinical trials in the gene therapy of arthritis Clinical Orthopaedics and Related Research  2000 S300-S307  PMID:11039783
• Lee, J. Y., Qu-Petersen, Z., Cao, B. H., Kimura, S., Jankowski, R., Cummins, J., Usas, A., Gates, C., Robbins, P., Wernig, A., Huard, J. Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing Journal of Cell Biology  2000 150:1085-1099  DOI:10.1083/jcb.150.5.1085  PMID:10973997
• Siegert, J. L., Rushton, J. J., Sellers, W. R., Kaelin, W. G., Robbins, P. D. Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity Oncogene  2000 19:5703-5711  DOI:10.1038/sj.onc.1203966  PMID:11126356
• Takayama, T., Morelli, A. E., Robbins, P. D., Tahara, H., Thomson, A. W. Feasibility of ctla4lg gene delivery and expression in vivo using retrovirally transduced myeloid dendritic cells that induce alloantigen-specific t cell anergy in vitro Gene Therapy  2000 7:1265-1273  DOI:10.1038/sj.gt.3301244  PMID:10918497
• Howard, M., Jiang, X. S., Stolz, D. B., Hill, W. G., Johnson, J. A., Watkins, S. C., Frizzell, R. A., Bruton, C. M., Robbins, P. D., Weisz, O. A. Forskolin-induced apical membrane insertion of virally expressed, epitope-tagged CFTR in polarized MDCK cells American Journal of Physiology-Cell Physiology  2000 279:C375-C382  PMID:10913004
• Ghivizzani, S. C., Oligino, T. J., Glorioso, J. C., Robbins, P. D., Evans, C. H. Gene therapy approaches for treating rheumatoid arthritis Clinical Orthopaedics and Related Research  2000 S288-S299  PMID:11039782
• Evans, C. H., Ghivizzani, S. C., Oligino, T. J., Robbins, P. D. Gene therapy for autoimmune disorders Journal of Clinical Immunology  2000 20:334-346  DOI:10.1023/a:1006616029205  PMID:11051275
• Kim, S. H., Evans, C. H., Kim, S., Oligino, T., Ghivizzani, S. C., Robbins, P. D. Gene therapy for established murine collagen-induced arthritis by local and systemic adenovirus-mediated delivery of interleukin-4 Arthritis Research  2000 2:293-302  DOI:10.1186/ar104  PMID:11056670  PMCID:PMC17812
• Londino, A. V., Rothman, D., Robbins, P. D., Evans, C. H. Gene therapy for juvenile rheumatoid arthritis? Journal of Rheumatology  2000 27:53-55  PMID:10782858
• Goto, H., Shuler, F. D., Niyibizi, C., Fu, F. H., Robbins, P. D., Evans, C. H. Gene therapy for meniscal injury: Enhanced synthesis of proteoglycan and collagen by meniscal cells transduced with a TGF beta(1) gene Osteoarthritis and Cartilage  2000 8:266-271  DOI:10.1053/joca.1999.0300  PMID:10903880
• Okada, H., Pollack, I. F., Lotze, M. T., Lunsford, L. D., Kondziolka, D., Lieberman, F., Schiff, D., Attanucci, J., Edington, H., Chambers, W., Robbins, P., Baar, J., et al. Gene therapy of malignant gliomas: A phase I study of IL-4-HSV-TK gene-modified autologous tumor to elicit an immune response Human Gene Therapy  2000 11:637-653  PMID:10724042
• Gambotto, A., Cicinnati, V., Robbins, P. D. Genetic approaches for biologic therapy of cancer Drugs of Today  2000 36:25-39  PMID:12879102
• Baltzer, A. W. A., Lattermann, C., Whalen, J. D., Wooley, P., Weiss, K., Grimm, M., Ghivizzani, S. C., Robbins, P. D., Evans, C. H. Genetic enhancement of fracture repair: Healing of an experimental segmental defect by adenoviral transfer of the BMP-2 gene Gene Therapy  2000 7:734-739  DOI:10.1038/sj.gt.3301166  PMID:10822299
• Smith, P., Shuler, F. D., Georgescu, H. I., Ghivizzani, S. C., Johnstone, B., Niyibizi, C., Robbins, P. D., Evans, C. H. Genetic enhancement of matrix synthesis by articular chondrocytes - comparison of different growth factor genes in the presence and absence of interleukin-1 Arthritis and Rheumatism  2000 43:1156-1164  DOI:10.1002/1529-0131(200005)43:5<1156::aid-anr26>3.0.co;2-m  PMID:10817570
• Moon, S. H., Gilbertson, L. G., Nishida, K., Knaub, M., Muzzonigro, T., Robbins, P. D., Evans, C. H., Kang, J. D. Human intervertebral disc cells are genetically modifiable by adenovirus-mediated gene transfer - implications for the clinical management of intervertebral disc disorders Spine  2000 25:2573-2579  DOI:10.1097/00007632-200010150-00006  PMID:11034640
• Gambotto, A., Dworacki, G., Cicinnati, V., Kenniston, T., Steitz, J., Tuting, T., Robbins, P. D., DeLeo, A. B. Immunogenicity of enhanced green fluorescent protein (EGFP) in BALB/c mice: Identification of an H2-Kd-restricted CTL epitope Gene Therapy  2000 7:2036-2040  DOI:10.1038/sj.gt.3301335  PMID:11175316
• Suzuki, K., Oyama, M., Faulcon, L., Robbins, P. D., Niyibizi, C. In vivo expression of human growth hormone by genetically modified murine bone marrow stromal cells and its effect on the cells in vitro Cell Transplantation  2000 9:319-327  PMID:10972331
• Shuler, F. D., Georgescu, H. I., Niyibizi, C., Studer, R. K., Mi, Z. B., Johnstone, B., Robbins, P. D., Evans, C. H. Increased matrix synthesis following adenoviral transfer of a transforming growth factor beta(1) gene into articular chondrocytes Journal of Orthopaedic Research  2000 18:585-592  DOI:10.1002/jor.1100180411  PMID:11052495
• Nixon, A. J., Brower-Toland, B. D., Bent, S. J., Saxer, R. A., Wilke, M. J., Robbins, P. D., Evans, C. H. Insulinlike growth factor-l gene therapy applications for cartilage repair Clinical Orthopaedics and Related Research  2000 S201-S213  PMID:11039770
• Lotze, M. T., Shurin, M., Esche, C., Tahara, H., Storkus, W., Kirkwood, J. M., Whiteside, T. L., Elder, E. M., Okada, H., Robbins, P. Interleukin-2: Developing additional cytokine gene therapies using fibroblasts or dendritic cells to enhance tumor immunity Cancer Journal from Scientific American  2000 6:S61-S66  PMID:10685662
• Saleh, A., Srinivasula, S. M., Balkir, L., Robbins, P. D., Alnemri, E. S. Negative regulation of the Apaf-1 apoptosome by Hsp70 Nature Cell Biology  2000 2:476-483  DOI:10.1038/35019510  PMID:10934467
• Bosch, P., Musgrave, D. S., Lee, J. Y., Cummins, J., Shuler, F., Ghivizzani, S. C., Evans, C., Robbins, P. D., Huard, J. Osteoprogenitor cells within skeletal muscle Journal of Orthopaedic Research  2000 18:933-944  DOI:10.1002/jor.1100180613  PMID:11192254
• Nishida, K., Gilbertson, L. G., Robbins, P. D., Evans, C. H., Kang, J. D. Potential applications of gene therapy to the treatment of intervertebral disc disorders Clinical Orthopaedics and Related Research  2000 S234-S241  PMID:11039775
• Niyibizi, C., Smith, P., Mi, Z. B., Robbins, P., Evans, C. Potential of gene therapy for treating osteogenesis imperfecta Clinical Orthopaedics and Related Research  2000 S126-S133  PMID:11039761
• Baltzer, A. W. A., Lattermann, C., Whalen, J. D., Ghivizzani, S., Wooley, P., Krauspe, R., Robbins, P. D., Evans, C. H. Potential role of direct adenoviral gene transfer in enhancing fracture repair Clinical Orthopaedics and Related Research  2000 S120-S125  PMID:11039760
• Giannoukakis, N., Mi, Z., Rudert, W. A., Gambotto, A., Trucco, M., Robbins, P. Prevention of beta cell dysfunction and apoptosis activation in human islets by adenoviral gene transfer of the insulin-like growth factor i Gene Therapy  2000 7:2015-2022  DOI:10.1038/sj.gt.3301333  PMID:11175313
• Giannoukakis, N., Bonham, C. A., Qian, S. G., Zhou, Z. Y., Peng, L., Harnaha, J., Li, W., Thomson, A. W., Fung, J. J., Robbins, P. D., Lu, L. Prolongation of cardiac allograft survival using dendritic cells treated with NF-kappa B decoy oligodeoxyribonucleotides Molecular Therapy  2000 1:430-437  DOI:10.1006/mthe.2000.0060  PMID:10933964
• Giannoukakis, N., Rudert, W. A., Trucco, M., Robbins, P. D. Protection of human islets from the effects of interleukin-1 beta by adenoviral gene transfer of an I kappa B repressor Journal of Biological Chemistry  2000 275:36509-36513  DOI:10.1074/jbc.M005943200  PMID:10967112
• Tanaka, F., Hashimoto, W., Okamura, H., Robbins, P. D., Lotze, M. T., Tahara, H. Rapid generation of potent and tumor-specific cytotoxic T lymphocytes by interleukin 18 using dendritic cells and natural killer cells Cancer Research  2000 60:4838-4844  PMID:10987295
• Morelli, A. E., Larregina, A. T., Ganster, R. W., Zahorchak, A. F., Plowey, J. M., Takayama, T., Logar, A. J., Robbins, P. D., Falo, L. D., Thomson, A. W. Recombinant adenovirus induces maturation of dendritic cells via an NF-kappa B-dependent pathway Journal of Virology  2000 74:9617-9628  DOI:10.1128/jvi.74.20.9617-9628.2000  PMID:11000234
• Kim, S. H., Kim, S. Y., Robbins, P. D. Retroviral vectors Advances in Virus Research  2000 55:545-563  DOI:10.1016/s0065-3527(00)55017-9  PMID:11050956
• Kubota, T., Bounoutas, G. S., Miyagishima, M., Kadokami, T., Sanders, V. J., Bruton, C., Robbins, P. D., McTiernan, C. F., Feldman, A. M. Soluble tumor necrosis factor receptor abrogates myocardial inflammation but not hypertrophy in cytokine-induced cardiomyopathy Circulation  2000 101:2518-2525  PMID:10831527
• Kang, R., Ghivizzani, S. C., Muzzonigro, T. S., Herndon, J. H., Robbins, P. D., Evans, C. H. The marshall r. Urist young investigator award. Orthopaedic applications of gene therapy. From concept to clinic Clinical Orthopaedics and Related Research  2000 324-337  PMID:10853185
• Pirtskhalaishvili, G., Shurin, G. V., Gambotto, A., Esche, C., Wahl, M., Yurkovetsky, Z. R., Robbins, P. D., Shurin, M. R. Transduction of dendritic cells with Bcl-xL increases their resistance to prostate cancer-induced apoptosis and antitumor effect in mice Journal of Immunology  2000 165:1956-1964  PMID:10925278
• Radfar, A. J., Robbins, P. D., Huard, J., Rosas, F. R., Dohar, J. E., Hebda, P. A. Transplantation of virally transduced cells into the dermis of immunocompetent and immunodeficient (SCID) mice to determine gene expression profile and differential donor cell survival Wound Repair and Regeneration  2000 8:503-510  DOI:10.1046/j.1524-475x.2000.00503.x  PMID:11208177
• Evans, C. H., Ghivizzani, S. C., Smith, P., Shuler, F. D., Mi, Z., Robbins, P. D. Using gene therapy to protect and restore cartilage Clinical Orthopaedics and Related Research  2000 S214-S219  PMID:11039771
• Oligino, T. J., Yao, Q. P., Ghivizzani, S. C., Robbins, P. Vector systems for gene transfer to joints Clinical Orthopaedics and Related Research  2000 S17-S30  PMID:11039748
• Baltzer, A. W. A., Lattermann, C., Whalen, J. D., Braunstein, S., Robbins, P. D., Evans, C. H. A gene therapy approach to accelerating bone healing. Evaluation of gene expression in a New Zealand white rabbit model Knee Surgery Sports Traumatology Arthroscopy  1999 7:197-202  DOI:10.1007/s001670050147  PMID:10401658
• Lu, L., Gambotto, A., Lee, W. C., Qian, S., Bonham, C. A., Robbins, P. D., Thomson, A. W. Adenoviral delivery of CTLA4ig into myeloid dendritic cells promotes their in vitro tolerogenicity and survival in allogeneic recipients Gene Therapy  1999 6:554-563  DOI:10.1038/sj.gt.3300862  PMID:10476215
• Giannoukakis, N., Rudert, W. A., Ghivizzani, S. C., Gambotto, A., Ricordi, C., Trucco, M., Robbins, P. D. Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1 beta-induced b-cell impairment and activation of islet cell apoptosis in vitro Diabetes  1999 48:1730-1736  DOI:10.2337/diabetes.48.9.1730  PMID:10480601
• Baltzer, A. W. A., Whalen, J. D., Stefanovic-Racic, M., Ziran, B., Robbins, P. D., Evans, C. H. Adenoviral transduction of human osteoblastic cell cultures - a new perspective for gene therapy of bone diseases Acta Orthopaedica Scandinavica  1999 70:419-424  DOI:10.3109/17453679909000974  PMID:10622471
• Whalen, J. D., Lechman, E. L., Carlos, C. A., Weiss, K., Kovesdi, I., Glorioso, J. C., Robbins, P. D., Evans, C. H. Adenoviral transfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws Journal of Immunology  1999 162:3625-3632  PMID:10092823
• Musgrave, D. S., Bosch, P., Ghivizzani, S., Robbins, P. D., Evans, C. H., Huard, J. Adenovirus-mediated direct gene therapy with bone morphogenetic protein-2 produces bone Bone  1999 24:541-547  DOI:10.1016/s8756-3282(99)00086-1  PMID:10375195
• Robbins, P. D., Evans, C. H. Arthritis gene therapy Drugs of Today  1999 35:353-360  PMID:12973438
• Esche, C., Gambotto, A., Satoh, Y., Gerein, V., Robbins, P. D., Watkins, S. C., Lotze, M. T., Shurin, M. R. CD154 inhibits tumor-induced apoptosis in dendritic cells and tumor growth European Journal of Immunology  1999 29:2148-2155  DOI:10.1002/(sici)1521-4141(199907)29:07<2148::aid-immu2148>3.0.co;2-f  PMID:10427977
• Ghivizzani, S. C., Muzzonigro, T. S., Kang, R., Evans, C. H., Robbins, P. D. Clinical gene therapy for arthritis Drugs of Today  1999 35:389-396  PMID:12973441
• Tuting, T., Gambotto, A., Robbins, P. D., Storkus, W. J., DeLeo, A. B. Co-delivery of T helper 1-biasing cytokine genes enhances the efficacy of gene gun immunization of mice: Studies with the model tumor antigen beta-galactosidase and the BALB/c Meth A p53 tumor-specific antigen Gene Therapy  1999 6:629-636  DOI:10.1038/sj.gt.3300859  PMID:10476222
• Adnane, J., Shao, Z. H., Robbins, P. D. Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription Oncogene  1999 18:239-247  DOI:10.1038/sj.onc.1202297  PMID:9926939
• Tuting, T., Steitz, J., Bruck, J., Gambotto, A., Steinbrink, K., DeLeo, A. B., Robbins, P., Knop, J., Enk, A. H. Dendritic cell-based genetic immunization in mice with a recombinant adenovirus encoding murine TRP2 induces effective anti-melanoma immunity Journal of Gene Medicine  1999 1:400-406  DOI:10.1002/(sici)1521-2254(199911/12)1:6<400::aid-jgm68>3.0.co;2-d  PMID:10753065
• Ranieri, E., Herr, W., Gambotto, A., Olson, W., Rowe, D., Robbins, P. D., Kierstead, L. S., Watkins, S. C., Gesualdo, L., Storkus, W. J. Dendritic cells transduced with an adenovirus vector encoding Epstein-Barr virus latent membrane protein 2B: A new modality for vaccination Journal of Virology  1999 73:10416-10425  PMID:10559360  PMCID:PMC113097
• Hashimoto, W., Osaki, T., Okamura, H., Robbins, P. D., Kurimoto, M., Nagata, S., Lotze, M. T., Tahara, H. Differential antitumor effects of administration of recombinant IL-18 or recombinant IL-12 are mediated primarily by Fas-Fas ligand- and perforin-induced tumor apoptosis, respectively Journal of Immunology  1999 163:583-589  PMID:10395644
• Lechman, E. R., Jaffurs, D., Ghivizzani, S. C., Gambotto, A., Kovesdi, I., Mi, Z. B., Evans, C. H., Robbins, P. D. Direct adenoviral gene transfer of viral IL-10 to rabbit knees with experimental arthritis ameliorates disease in both injected and contralateral control knees Journal of Immunology  1999 163:2202-2208  PMID:10438962
• Hildebrand, K. A., Deie, M., Allen, C. R., Smith, D. W., Georgescu, H. I., Evans, C. H., Robbins, P. D., Woo, S. L. Y. Early expression of marker genes in the rabbit medial collateral and anterior cruciate ligaments: The use of different viral vectors and the effects of injury Journal of Orthopaedic Research  1999 17:37-42  DOI:10.1002/jor.1100170107  PMID:10073645
• Evans, C. H., Ghivizzani, S. C., Kang, R., Muzzonigro, T., Wasko, M. C., Herndon, J. H., Robbins, P. D. Gene therapy for rheumatic diseases Arthritis and Rheumatism  1999 42:1-16  DOI:10.1002/1529-0131(199901)42:1<1::aid-anr1>3.0.co;2-4  PMID:9920008
• Giannoukakis, N., Thomson, A. W., Robbins, P. D. Gene therapy in transplantation Gene Therapy  1999 6:1499-1511  DOI:10.1038/sj.gt.3300981  PMID:10490759
• Evans, C. H., Robbins, P. D. Gene therapy of arthritis Internal Medicine  1999 38:233-239  DOI:10.2169/internalmedicine.38.233  PMID:10337932
• Muller-Ladner, U., Evans, C. H., Franklin, B. N., Roberts, C. R., Gay, R. E., Robbins, P. D., Gay, S. Gene transfer of cytokine inhibitors into human synovial fibroblasts in the SCIS mouse model Arthritis and Rheumatism  1999 42:490-497  DOI:10.1002/1529-0131(199904)42:3<490::aid-anr14>3.0.co;2-l  PMID:10088772
• Lu, L., Lee, W. C., Takayama, T., Qian, S. G., Gambotto, A., Robbins, P. D., Thomson, A. W. Genetic engineering of dendritic cells to express immunosuppressive molecules (viral IL-10, TGF-beta, and CTLA4lg) Journal of Leukocyte Biology  1999 66:293-296  PMID:10449170
• Evans, C. H., Robbins, P. D. Genetically augmented tissue engineering of the musculoskeletal system Clinical Orthopaedics and Related Research  1999 S410-S418  PMID:10546663
• Bertera, S., Alexander, A., Giannoukakis, N., Robbins, P. D., Trucco, M. Immunology of type 1 diabetes - intervention and prevention strategies Endocrinology and Metabolism Clinics of North America  1999 28:841-64, x  DOI:10.1016/s0889-8529(05)70105-5  PMID:10609123
• Baltzer, A. W. A., Whalen, J. D., Muzzonegro, T., Georgescu, H. I., Robbins, P. D., Evans, C. H. In vitro transduction of human osteoblast cell population with retroviral vectors Zeitschrift für Rheumatologie  1999 58:88-94  DOI:10.1007/s003930050157  PMID:10408069
• Gambotto, A., Tuting, T., McVey, D. L., Kovesdi, I., Tahara, H., Lotze, M. T., Robbins, P. D. Induction of antitumor immunity by direct intratumoral injection of a recombinant adenovirus vector expressing interleukin-12 Cancer Gene Therapy  1999 6:45-53  DOI:10.1038/sj.cgt.7700013  PMID:10078963
• Nishioka, Y., Hirao, M., Robbins, P. D., Lotze, M. T., Tahara, H. Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12 Cancer Research  1999 59:4035-4041  PMID:10463604
• Tuting, T., Gambotto, A., DeLeo, A., Lotze, M. T., Robbins, P. D., Storkus, W. J. Induction of tumor antigen-specific immunity using plasmid DNA immunization in mice Cancer Gene Therapy  1999 6:73-80  DOI:10.1038/sj.cgt.7700020  PMID:10078966
• Giannoukakis, N., Mi, Z., Gambotto, A., Eramo, A., Ricordi, C., Trucco, M., Robbins, P. D. Infection of intact human islets by a lentiviral vector Gene Therapy  1999 6:1545-1551  DOI:10.1038/sj.gt.3300996  PMID:10490763
• Oligino, T., Ghivizzani, S. C., Wolfe, D., Lechman, E. R., Krisky, D., Mi, Z., Evans, C. H., Robbins, P. D., Glorioso, J. C. Intra-articular delivery of a herpes simplex virus il-1ra gene vector reduces inflammation in a rabbit model of arthritis Gene Therapy  1999 6:1713-1720  DOI:10.1038/sj.gt.3301014  PMID:10516720
• Nishida, K., Kang, J. D., Gilbertson, L. G., Moon, S. H., Suh, J. K., Vogt, M. T., Robbins, P. D., Evans, C. H. Modulation of the biologic activity of the rabbit intervertebral disc by gene therapy: An in vivo study of adenovirus-mediated transfer of the human transforming growth factor beta 1 encoding gene Spine  1999 24:2419-2425  DOI:10.1097/00007632-199912010-00002  PMID:10626303
• Studer, R., Jaffurs, D., Stefanovic-Racic, M., Robbins, P. D., Evans, C. H. Nitric oxide in osteoarthritis Osteoarthritis and Cartilage  1999 7:377-379  DOI:10.1053/joca.1998.0216  PMID:10419772
• Osaki, T., Hashimoto, W., Gambotto, A., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T., Tahara, H. Potent antitumor effects mediated by local expression of the mature form of the interferon-gamma inducing factor, interleukin-18 (IL-18) Gene Therapy  1999 6:808-815  DOI:10.1038/sj.gt.3300908  PMID:10505105
• Evans, C. H., Robbins, P. D. Potential treatment of osteoarthritis by gene therapy Rheumatic Disease Clinics of North America  1999 25:333-44  DOI:10.1016/s0889-857x(05)70071-5  PMID:10356421
• Siegert, J. L., Robbins, P. D. Rb inhibits the intrinsic kinase activity of TATA-binding protein-associated factor TAF(II)250 Molecular and Cellular Biology  1999 19:846-854  PMID:9858607  PMCID:PMC83941
• Oyama, M., Tatlock, A., Fukuta, S., Kavalkovich, K., Nishimura, K., Johnstone, B., Robbins, P. D., Evans, C. H., Niyibizi, C. Retrovirally transduced bone marrow stromal cells isolated from a mouse model of human osteogenesis imperfecta (oim) persist in bone and retain the ability to form cartilage and bone after extended passaging Gene Therapy  1999 6:321-329  DOI:10.1038/sj.gt.3300839  PMID:10435082
• Giannoukakis, N., Rudert, W. A., Robbins, P. D., Trucco, M. Targeting autoimmune diabetes with gene therapy Diabetes  1999 48:2107-2121  DOI:10.2337/diabetes.48.11.2107  PMID:10535443
• Muzzonigro, T. S., Ghivizzani, S. C., Robbins, P. D., Evans, C. H. The role of gene therapy - fact or fiction? Clinics in Sports Medicine  1999 18:223-39, vii  DOI:10.1016/s0278-5919(05)70136-8  PMID:10028123
• Lu, L., Lee, W. C., Gambotto, A., Zhong, C., Robbins, P. D., Qian, S., Fung, J. J., Thomson, A. W. Transduction of dendritic cells with adenoviral vectors encoding ctla4-ig markedly reduces their allostimulatory activity Transplantation Proceedings  1999 31:797-797  DOI:10.1016/s0041-1345(98)01774-6  PMID:10083343
• Goto, H., Shuler, F. D., Lamsam, C., Moller, H. D., Niyibizi, C., Fu, F. H., Robbins, P. D., Evans, C. H. Transfer of lacZ marker gene to the meniscus Journal of Bone and Joint Surgery-American Volume  1999 81A:918-925  PMID:10428122
• Nishida, K., Kang, J. D., Suh, J. K., Robbins, P. D., Evans, C. H., Gilbertson, L. G. Adenovirus-mediated gene transfer to nucleus pulposus cells - implications for the treatment of intervertebral disc degeneration Spine  1998 23:2437-2442  DOI:10.1097/00007632-199811150-00016  PMID:9836359
• Merly, F., Huard, C., Asselin, I., Robbins, P. D., Tremblay, J. P. Anti-inflammatory effect of transforming growth factor-beta 1 in myoblast transplantation Transplantation  1998 65:793-799  DOI:10.1097/00007890-199803270-00005  PMID:9539090
• Evans, C. H., Ghivizzani, S. C., Robbins, P. D. Blocking cytokines with genes Journal of Leukocyte Biology  1998 64:55-61  PMID:9665275
• Kim, S. H., Yu, S. S., Park, J. S., Robbins, P. D., An, C. S., Kim, S. Construction of retroviral vectors with improved safety, gene expression, and versatility Journal of Virology  1998 72:994-1004  PMID:9444992  PMCID:PMC124570
• Qu, Z. Q., Balkir, L., van Deutekom, J. C. T., Robbins, P. D., Pruchnic, R., Huard, J. Development of approaches to improve cell survival in myoblast transfer therapy Journal of Cell Biology  1998 142:1257-1267  DOI:10.1083/jcb.142.5.1257  PMID:9732286
• Yang, Y. Y., Robbins, P. D., Lazo, J. S. Differential transactivation of human metallothionein-IIa in cisplatin-resistant and -sensitive cells Oncology Research  1998 10:85-98  PMID:9666516
• Ghivizzani, S. C., Lechman, E. R., Kang, R., Tio, C., Kolls, J., Evans, C. H., Robbins, P. D. Direct adenovirus-mediated gene transfer of interleukin 1 and tumor necrosis factor alpha soluble receptors to rabbit knees with experimental arthritis has local and distal anti-arthritic effects Proceedings of the National Academy of Sciences of the United States of America  1998 95:4613-4618  DOI:10.1073/pnas.95.8.4613  PMID:9539786
• Douin-Echinard, V., Robbins, P. D., Lotze, M. T., Favre, G., Couderc, B. Enhancement of anti-tumor immunity by injection of fibroblasts genetically engineered to produce IL-12 and to express CD70 Advances in Experimental Medicine and Biology  1998 451:353-357  PMID:10026896
• Couderc, B., Zitvogel, L., Douin-Echinard, V., Djennane, L., Tahara, H., Favre, G., Lotze, M. T., Robbins, P. D. Enhancement of antitumor immunity by expression of CD70 (CD27 ligand) or CD154 (CD40 ligand) costimulatory molecules in tumor cells Cancer Gene Therapy  1998 5:163-175  PMID:9622100
• Robbins, P. D., Evans, C. H., Chernajovsky, Y. Gene therapy for rheumatoid arthritis Springer Seminars in Immunopathology  1998 20:197-209  DOI:10.1007/bf00832007  PMID:9836377
• Evans, C. H., Whalen, J. D., Ghivizzani, S. C., Robbins, P. D. Gene therapy in autoimmune diseases Annals of the Rheumatic Diseases  1998 57:125-127  DOI:10.1136/ard.57.3.125  PMID:9640124
• Lamsam, C., Fu, F. H., Robbins, P. D., Evans, C. H. Gene therapy in sports medicine Sports Medicine  1998 25:73-77  DOI:10.2165/00007256-199825020-00001  PMID:9519397
• Lattermann, C., Baltzer, A. W. A., Whalen, J. D., Evans, C. H., Robbins, P. D., Fu, F. H. Gene therapy in sports medicine Sports Medicine and Arthroscopy Review  1998 6:83-88
• Osaki, T., Peron, J. M., Cai, Q. A., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T., Tahara, H. Ifn-gamma-inducing factor il-18 administration mediates ifn-gamma- and il-12-independent antitumor effects Journal of Immunology  1998 160:1742-1749  PMID:9469432
• Lee, W. C., Zhong, C., Qian, S., Wan, Y., Gauldie, J., Mi, Z., Robbins, P. D., Thomson, A. W., Lu, L. Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-beta Transplantation  1998 66:1810-1817  DOI:10.1097/00007890-199812270-00040  PMID:9884280
• Niyibizi, C., Baltzer, A., Lattermann, C., Oyama, M., Whalen, J. D., Robbins, P. D., Evans, C. H. Potential role for gene therapy in the enhancement of fracture healing Clinical Orthopaedics and Related Research  1998 S148-S153  PMID:9917635
• Henderson, R. A., Konitsky, W. M., Barratt-Boyes, S. M., Soares, M., Robbins, P. D., Finn, O. J. Retroviral expression of MUC-1 human tumor antigen with intact repeat structure and capacity to elicit immunity in vivo Journal of Immunotherapy  1998 21:247-256  DOI:10.1097/00002371-199807000-00002  PMID:9672846
• Nagashima, S., Mailliard, R., Kashii, Y., Reichert, T. E., Herberman, R. B., Robbins, P., Whiteside, T. L. Stable transduction of the interleukin-2 gene into human natural killer cell lines and their phenotypic and functional characterization in vitro and in vivo Blood  1998 91:3850-3861  PMID:9573023
• Byun, J., Kim, J. M., Robbins, P. D., Kim, S. The selectable marker neo gene down-regulates gene expression from retroviral vectors containing an internal ribosome entry site Gene Therapy  1998 5:1441-1444  DOI:10.1038/sj.gt.3300762  PMID:9930351
• Robbins, P. D., Ghivizzani, S. C. Viral vectors for gene therapy Pharmacology & Therapeutics  1998 80:35-47  DOI:10.1016/s0163-7258(98)00020-5  PMID:9804053
• Robbins, P. D., Tahara, H., Ghivizzani, S. C. Viral vectors for gene therapy Trends in Biotechnology  1998 16:35-40  DOI:10.1016/s0167-7799(97)01137-2  PMID:9470229
• Reinecke, J. A., Wehling, P., Robbins, P., Evans, C. H., Sager, M., SchulzeAllen, G., Koch, H. In vitro transfer of genes into spinal tissues Zeitschrift Fur Orthopadie Und Ihre Grenzgebiete  1997 135:412-416  DOI:10.1055/s-2008-1039409
• Ghivizzani, S. C., Kang, R., Georgescu, H. I., Lechman, E. R., Jaffurs, D., Engle, J. M., Watkins, S. C., Tindal, M. H., Suchanek, M. K., McKenzie, L. R., Evans, C. H., Robbins, P. D. Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis Journal of Immunology  1997 159:3604-3612  PMID:9317160
• Doughty, L. A., Patrene, K. D., Evans, C. H., Boggs, S. S., Robbins, P. D. Constitutive systemic expression of il-1ra or soluble tnf receptor by genetically modified hematopoietic cells suppresses lps induction of il-6 and il-10 Gene Therapy  1997 4:252-257  DOI:10.1038/sj.gt.3300387  PMID:9135739
• Rushton, J. J., Steinman, R. A., Robbins, P. D. Differential regulation of transcription of p21 and cyclin D1 conferred by TAF(II)250 Cell Growth and Differentiation  1997 8:1099-1104  PMID:9342188
• Ghivizzani, S. C., Lechman, E. R., Tio, C., Mule, K. M., Chada, S., McCormack, J. E., Evans, C. H., Robbins, P. D. Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: Implications for arthritis gene therapy Gene Therapy  1997 4:977-982  DOI:10.1038/sj.gt.3300486  PMID:9349435
• Kang, R., Marui, T., Ghivizzani, S. C., Nita, I. M., Georgescu, H. I., Suh, J. K., Robbins, P. D., Evans, C. H. Ex vivo gene transfer to chondrocytes in full-thickness articular cartilage defects: A feasibility study Osteoarthritis and Cartilage  1997 5:139-143  DOI:10.1016/s1063-4584(97)80007-6  PMID:9135825
• Kang, R., Ghivizzani, S. C., Herndon, J. H., Robbins, P. D., Evans, C. H. Gene therapy for arthritis: principles and clinical practice Biochemical Society Transactions  1997 25:533-537  PMID:9191150
• MullerLadner, U., Roberts, C. R., Franklin, B. N., Gay, R. E., Robbins, P. D., Evans, C. H., Gay, S. Human IL-1ra gene transfer into human synovial fibroblasts is chondroprotective Journal of Immunology  1997 158:3492-3498  PMID:9120311
• Pelletier, J. P., Caron, J. P., Evans, C., Robbins, P. D., Georgescu, H. I., Jovanovic, D., Fernandes, J. C., MartelPelletier, J. In vivo suppression of early experimental osteoarthritis by interleukin-1 receptor antagonist using gene therapy Arthritis and Rheumatism  1997 40:1012-1019  DOI:10.1002/art.1780400604  PMID:9182910
• Tuting, T., Gambotto, A., Baar, J., Davis, I. D., Storkus, W. J., Zavodny, P. J., Narula, S., Tahara, H., Robbins, P. D., Lotze, M. T. Interferon-alpha gene therapy for cancer: Retroviral transduction of fibroblasts and particle-mediated transfection of tumor cells are both effective strategies for gene delivery in murine tumor models Gene Therapy  1997 4:1053-1060  DOI:10.1038/sj.gt.3300509  PMID:9415311
• Glorioso, J. C., Krisky, D., Marconi, P., Oligino, T., Ghivizzani, S. C., Robbins, P. D., Schmidt, M. C., Goins, W. F., Evans, C. Progress in development of herpes simplex virus gene vectors for treatment of rheumatoid arthritis Advanced Drug Delivery Reviews  1997 27:41-57  DOI:10.1016/s0169-409x(97)00021-5  PMID:10837550
• Shao, Z. H., Siegert, J. L., Ruppert, S., Robbins, P. D. Rb interacts with TAF(II)250/TFIID through multiple domains Oncogene  1997 15:385-392  DOI:10.1038/sj.onc.1201204  PMID:9242374
• Kim, S. H., An, C. S., Tahara, H., Park, C., Lotze, M. T., Robbins, P. D., Kim, S. Retroviral-mediated IL-12 gene therapy for advanced murine tumors Experimental and Molecular Medicine  1997 29:53-58  DOI:10.1038/emm.1997.8
• Rushton, J. J., Jiang, D., Srinivasan, A., Pipas, J. M., Robbins, P. D. Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53 Journal of Virology  1997 71:5620-5623  PMID:9188637  PMCID:PMC191805
• Wehling, P., Schulitz, K. P., Robbins, P. D., Evans, C. H., Reinecke, J. A. Transfer of genes to chondrocytic cells of the lumbar spine. Proposal for a treatment strategy of spinal disorders by local gene therapy Spine  1997 22:1092-1097  DOI:10.1097/00007632-199705150-00008  PMID:9160467
• Learish, R., Ohashi, T., Robbins, P. D., Bahnson, A., Boggs, S. S., Patrene, K., Schwartz, B. E., Gieselmann, V., Barranger, J. A. Retroviral gene transfer and sustained expression of human arylsulfatase A Gene Therapy  1996 3:343-349  PMID:8732166
• Byun, J., Kim, J. M., Kim, S. H., Yim, J., Robbins, P. D., Kim, S. A simple and rapid method for the determination of recombinant retrovirus titer by G418 selection Gene Therapy  1996 3:1018-1020  PMID:9044742
• Byun, J., Kim, S. H., Kim, J. M., Yu, S. S., Robbins, P. D., Yim, J., Kim, S. Analysis of the relative level of gene expression from different retroviral vectors used for gene therapy Gene Therapy  1996 3:780-788  PMID:8875226
• Evans, C. H., Mankin, H. J., Ferguson, A. B., Robbins, P. D., Ghivizzani, S. C., Herndon, J. H., Kang, R., Tomaino, M. M., Wright, T. M. Clinical trial to assess the safety, feasibility, and efficacy of transferring a potentially anti-arthritic cytokine gene to human joints with rheumatoid arthritis Human Gene Therapy  1996 7:1261-1280  DOI:10.1089/hum.1996.7.10-1261  PMID:8793551
• Lotze, M. T., Zitvogel, L., Campbell, R., Robbins, P. D., Elder, E., Haluszczak, C., Martin, D., Whiteside, T. L., Storkus, W. J., Tahara, H. Cytokine gene therapy of cancer using interleukin-12: murine and clinical trials Annals of the New York Academy of Sciences  1996 795:440-454  DOI:10.1111/j.1749-6632.1996.tb52715.x  PMID:8958977
• Nita, I., Ghivizzani, S. C., GaleaLauri, J., Bandara, G., Georgescu, H. I., Robbins, P. D., Evans, C. H. Direct gene delivery to synovium - an evaluation of potential vectors in vitro and in vivo Arthritis and Rheumatism  1996 39:820-828  DOI:10.1002/art.1780390515  PMID:8639179
• Lin, C. W., Robbins, P. D., Georgescu, H. I., Evans, C. H. Effects of immortalization upon the induction of matrix metalloproteinases in rabbit synovial fibroblasts Experimental Cell Research  1996 223:117-126  DOI:10.1006/excr.1996.0064  PMID:8635483
• Gerich, T. G., Kang, R., Fu, F. H., Robbins, P. D., Evans, C. H. Gene transfer to the rabbit patellar tendon: potential for genetic enhancement of tendon and ligament healing Gene Therapy  1996 3:1089-1093  PMID:8986435
• Henderson, R. A., Nimgaonkar, M. T., Watkins, S. C., Robbins, P. D., Ball, E. D., Finn, O. J. Human dendritic cells genetically engineered to express high levels of the human epithelial tumor antigen mucin (MUC-1) Cancer Research  1996 56:3763-3770  PMID:8706022
• Zitvogel, L., Couderc, B., Mayordomo, J. I., Robbins, P. D., Lotze, M. T., Storkus, W. J. IL-12-engineered dendritic cells serve as effective tumor vaccine adjuvants in vivo Annals of the New York Academy of Sciences  1996 795:284-293  DOI:10.1111/j.1749-6632.1996.tb52678.x  PMID:8958940
• DeKosky, S. T., Styren, S. D., O'Malley, M. E., Goss, J. R., Kochanek, P., Marion, D., Evans, C. H., Robbins, P. D. Interleukin-1 receptor antagonist suppresses neurotrophin response in injured rat brain Annals of Neurology  1996 39:123-127  DOI:10.1002/ana.410390118  PMID:8572657
• Zitvogel, L., Robbins, P. D., Storkus, W. J., Clarke, M. R., Maeurer, M. J., Campbell, R. L., Davis, C. G., Tahara, H., Schreiber, R. D., Lotze, M. T. Interleukin-12 and B7.1 co-stimulation cooperate in the induction of effective antitumor immunity and therapy of established tumors European Journal of Immunology  1996 26:1335-1341  DOI:10.1002/eji.1830260624  PMID:8647214
• Tahara, H., Zitvogel, L., Storkus, W. J., Robbins, P. D., Lotze, M. T. Murine models of cancer cytokine gene therapy using interleukin-12 Annals of the New York Academy of Sciences  1996 795:275-283  DOI:10.1111/j.1749-6632.1996.tb52677.x  PMID:8958939
• Lee, S. G., Kim, S., Robbins, P. D., Kim, B. G. Optimization of environmental factors for the production and handling of recombinant retrovirus Applied Microbiology and Biotechnology  1996 45:477-483  PMID:8737571
• Evans, C. H., Hand, M., Robbins, P. D. Patenting gene therapy for arthritis Expert Opinion on Therapeutic Patents  1996 6:253-257  DOI:10.1517/13543776.6.3.253
• Qin, L. H., Chavin, K. D., Ding, Y. Z., Tahara, H., Favaro, J. P., Woodward, J. E., Suzuki, T., Robbins, P. D., Lotze, M. T., Bromberg, J. S. Retrovirus-mediated transfer of viral IL-10 gene prolongs murine cardiac allograft survival Journal of Immunology  1996 156:2316-2323  PMID:8690923
• Otani, K., Nita, I., Macaulay, W., Georgescu, H. I., Robbins, P. D., Evans, C. H. Suppression of antigen-induced arthritis in rabbits by ex vivo gene therapy Journal of Immunology  1996 156:3558-3562  PMID:8617986
• Berman, R. M., Suzuki, T., Tahara, H., Robbins, P. D., Narula, S. K., Lotze, M. T. Systemic administration of cellular IL-10 induces an effective, specific, and long-lived immune response against established tumors in mice Journal of Immunology  1996 157:231-238  PMID:8683120
• Evans, C. H., Robbins, P. D. The promise of a new clinical trial - intra-articular il-1 receptor antagonist Proceedings of the Association of American Physicians  1996 108:1-5  PMID:8834057
• Maeurer, M. J., Gollin, S. M., Martin, D., Swaney, W., Bryant, J., Castelli, C., Robbins, P., Parmiani, G., Storkus, W. J., Lotze, M. T. Tumor escape from immune recognition: lethal recurrent melanoma in a patient associated with downregulation of the peptide transporter protein TAP-1 and loss of expression of the immunodominant MART-1/Melan-A antigen Journal of Clinical Investigation  1996 98:1633-1641  DOI:10.1172/jci118958  PMID:8833913  PMCID:PMC507597
• Tzeng, E., Shears, L. L., Robbins, P. D., Pitt, B. R., Geller, D. A., Watkins, S. C., Simmons, R. L., Billiar, T. R. Vascular gene transfer of the human inducible nitric oxide synthase: Characterization of activity and effects on myointimal hyperplasia Molecular Medicine  1996 2:211-225  PMID:8726464  PMCID:PMC2230119
• Qin, L., Chavin, K. D., Ding, Y., Favaro, J. P., Woodward, J. E., Lin, J., Tahara, H., Robbins, P., Shaked, A., Ho, D. Y., Sapolsky, R. M., Lotze, M. T., et al. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Immunosuppression with TGF-beta 1 or vIL-10. Transplantation  1995 59:809-816  DOI:10.1097/00007890-199503270-00002  PMID:7701573
• Pappo, I., Tahara, H., Robbins, P. D., Gately, M. K., Wolf, S. F., Barnea, A., Lotze, M. T. Administration of systemic or local interleukin-2 enhances the antitumor effects of interleukin-12 gene-therapy Journal of Surgical Research  1995 58:218-226  DOI:10.1006/jsre.1995.1034  PMID:7861776
• Zitvogel, L., Tahara, H., Robbins, P. D., Storkus, W. J., Clarke, M. R., Nalesnik, M. A., Lotze, M. T. Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts Journal of Immunology  1995 155:1393-1403  PMID:7636204
• Mueller, G. M., McKenzie, L. R., Homanics, G. E., Watkins, S. C., Robbins, P. D., Paul, H. S. Complementation of defective leucine decarboxylation in fibroblasts from a maple syrup urine disease patient by retrovirus-mediated gene transfer Gene Therapy  1995 2:461-468  PMID:7584124
• Shao, Z. H., Robbins, P. D. Differential regulation of E2F and Sp1-mediated transcription by G1 cyclins Oncogene  1995 10:221-228  PMID:7838522
• Tahara, H., Zitvogel, L., Storkus, W. J., Zeh, H. J., McKinney, T. G., Schreiber, R. D., Gubler, U., Robbins, P. D., Lotze, M. T. Effective eradication of established murine tumors with IL-12 gene-therapy using a polycistronic retroviral vector Journal of Immunology  1995 154:6466-6474  PMID:7759882
• Tzeng, E., Billiar, T. R., Robbins, P. D., Loftus, M., Stuehr, D. J. Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line: H4b promotes assembly of enzyme subunits into an active dimer Proceedings of the National Academy of Sciences of the United States of America  1995 92:11771-11775  DOI:10.1073/pnas.92.25.11771  PMID:8524846  PMCID:PMC40484
• Tahara, H., Lotze, M., Robbins, P. D., Storkus, W. J., Zitvogel, L. IL-12 gene therapy using direct injection of tumors with genetically engineered autologous fibroblasts Human Gene Therapy  1995 6:1607-1624  DOI:10.1089/hum.1995.6.12-1607  PMID:8664385
• Chernajovsky, Y., Adams, G., Podhajcer, O. L., Mueller, G. M., Robbins, P. D., Feldmann, M. Inhibition of transfer of collagen-induced arthritis into SCID mice by ex vivo infection of spleen cells with retroviruses expressing soluble tumor necrosis factor receptor Gene Therapy  1995 2:731-735  PMID:8750012
• Schwarz, M. A., Lazo, J. S., Yalowich, J. C., Allen, W. P., Whitmore, M., Bergonia, H. A., Tzeng, E., Billiar, T. R., Robbins, P. D., Lancaster, J. R., Pitt, B. R. Metallothionein protects against the cytotoxic and DNA-damaging effects of nitric-oxide Proceedings of the National Academy of Sciences of the United States of America  1995 92:4452-4456  DOI:10.1073/pnas.92.10.4452  PMID:7538671
• Evans, C. H., Robbins, P. D. Possible orthopaedic applications of gene-therapy Journal of Bone and Joint Surgery-American Volume  1995 77A:1103-1114  PMID:7608237
• Evans, C. H., Robbins, P. D. Progress toward the treatment of arthritis by gene-therapy Annals of Medicine  1995 27:543-546  DOI:10.3109/07853899509002466  PMID:8541029
• Boggs, S. S., Patrene, K. D., Mueller, G. M., Evans, C. H., Doughty, L. A., Robbins, P. D. Prolonged systemic expression of human IL-1 receptor antagonist (hIL-1ra) in mice reconstituted with hematopoietic-cells transduced with a retrovirus carrying the hIL-1ra cDNA Gene Therapy  1995 2:632-638  PMID:8548552
• Pitt, B. R., Schwarz, M. A., Pilewski, J. M., Nakayama, D., Mueller, G. M., Robbins, P. D., Watkins, S. A., Albertine, K. H., Bland, R. D. Retrovirus-mediated gene transfer in lungs of living fetal sheep Gene Therapy  1995 2:344-350  PMID:7671110
• Adnane, J., Robbins, P. D. The retinoblastoma susceptibility gene-product regulates Myc-mediated transcription Oncogene  1995 10:381-387  PMID:7838535
• Adnane, J., Shao, Z. H., Robbins, P. D. The retinoblastoma susceptibility gene-product represses transcription when directly bound to the promoter Journal of Biological Chemistry  1995 270:8837-8843  PMID:7721791
• Shao, Z. H., Ruppert, S., Robbins, P. D. The retinoblastoma-susceptibility gene-product binds directly to the human tata-binding protein-associated factor taf(ii)250 Proceedings of the National Academy of Sciences of the United States of America  1995 92:3115-3119  DOI:10.1073/pnas.92.8.3115  PMID:7724524
• Robbins, P. D., Shao, Z. H., Adnane, J., Siegert, J. L. Transcriptional regulation by the retinoblastoma tumor suppressor protein Molecules and Cells  1995 5:529-538
• Suzuki, T., Tahara, H., Narula, S., Moore, K. W., Robbins, P. D., Lotze, M. T. Viral interleukin-10 (IL-10), the human herpes-virus-4 cellular IL-10 homolog, induces local anergy to allogeneic and syngeneic tumors Journal of Experimental Medicine  1995 182:477-486  DOI:10.1084/jem.182.2.477  PMID:7629507
• Ohtanifujita, N., Fujita, T., Takahashi, R., Robbins, P. D., Dryja, T. P., Sakai, T. A silencer element in the retinoblastoma tumor-suppressor gene Oncogene  1994 9:1703-1711  PMID:8183566
• Gao, X., Jaffurs, D., Robbins, P. D., Huang, L. A sustained, cytoplasmic transgene expression system delivered by cationic liposomes Biochemical and Biophysical Research Communications  1994 200:1201-1206  DOI:10.1006/bbrc.1994.1578  PMID:8185568
• Zitvogel, L., Tahara, H., Cai, Q., Storkus, W. J., Muller, G., Wolf, S. F., Gately, M., Robbins, P. D., Lotze, M. T. Construction and characterization of retroviral vectors expressing biologically active human interleukin-12 Human Gene Therapy  1994 5:1493-1506  DOI:10.1089/hum.1994.5.12-1493  PMID:7711142
• Tahara, H., Zeh, H. J., Storkus, W. J., Pappo, I., Watkins, S. C., Gubler, U., Wolf, S. F., Robbins, P. D., Lotze, M. T. Fibroblasts genetically engineered to secrete interleukin 12 can suppress tumor growth and induce antitumor immunity to a murine melanoma in vivo Cancer Research  1994 54:182-189  PMID:7903204
• Osifchin, N. E., Jiang, D., Ohtanifujita, N., Fujita, T., Carroza, M., Kim, S. J., Sakai, T., Robbins, P. D. Identification of a p53 binding-site in the human retinoblastoma susceptibility gene promoter Journal of Biological Chemistry  1994 269:6383-6389  PMID:8119988
• Robbins, P. D., Tahara, H., Mueller, G., Hung, G., Bahnson, A., Zitvogel, L., Galealauri, J., Ohashi, T., Patrene, K., Boggs, S. S., Evans, C. H., Barranger, J. A., et al. Retroviral vectors for use in human gene-therapy for cancer Gaucher disease, and arthritis Annals of the New York Academy of Sciences  1994 716:72-89  DOI:10.1111/j.1749-6632.1994.tb21704.x  PMID:7912915
• Hung, G. L., Galealauri, J., Mueller, G. M., Georgescu, H. I., Larkin, L. A., Suchanek, M. K., Tindal, M. H., Robbins, P. D., Evans, C. H. Suppression of intraarticular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium Gene Therapy  1994 1:64-69  PMID:7584062
• Park, K., Choe, J., Osifchin, N. E., Templeton, D. J., Robbins, P. D., Kim, S. J. The human retinoblastoma susceptibility gene promoter is positively autoregulated by its own product Journal of Biological Chemistry  1994 269:6083-6088  PMID:8119953
• Evans, C. H., Robbins, P. D. The interleukin-1 receptor antagonist and its delivery by gene-transfer Receptor  1994 4:9-15  PMID:8038709
• Bahnson, A. B., Nimgaonkar, M., Fei, Y., Boggs, S. S., Robbins, P. D., Ohashi, T., Dunigan, J., Li, J., Ball, E. D., Barranger, J. A. Transduction of CD34+ enriched cord-blood and Gaucher bone-marrow cells by a retroviral vector carrying the glucocerebrosidase gene Gene Therapy  1994 1:176-184  PMID:7584079
• Jackson, B. J., Kukuruzinska, M. A., Robbins, P. Biosynthesis of asparagine-linked oligosaccharides in saccharomyces-cerevisiae - the alg2 mutation Glycobiology  1993 3:357-364  DOI:10.1093/glycob/3.4.357  PMID:8400550
• Ohtanifujita, N., Fujita, T., Aoike, A., Osifchin, N. E., Robbins, P. D., Sakai, T. CpG methylation inactivates the promoter activity of the human retinoblastoma tumor-suppressor gene Oncogene  1993 8:1063-1067  PMID:8455933
• Bandara, G., Mueller, G. M., Galealauri, J., Tindal, M. H., Georgescu, H. I., Suchanek, M. K., Hung, G. L., Glorioso, J. C., Robbins, P. D., Evans, C. H. Intraarticular expression of biologically-active interleukin-1 receptor-antagonist protein by ex-vivo gene-transfer Proceedings of the National Academy of Sciences of the United States of America  1993 90:10764-10768  DOI:10.1073/pnas.90.22.10764  PMID:8248169  PMCID:PMC47858
• Calmels, T. P. G., Mistry, J. S., Watkins, S. C., Robbins, P. D., McGuire, R., Lazo, J. S. Nuclear-localization of bacterial Streptoalloteichus-hindustanus bleomycin resistance protein in mammalian-cells Molecular Pharmacology  1993 44:1135-1141  PMID:7505390
• Jiang, D., Srinivasan, A., Lozano, G., Robbins, P. D. SV40 T-antigen abrogates p53-mediated transcriptional activity Oncogene  1993 8:2805-2812  PMID:8378089
• Delic, I., Robbins, P., Westpheling, J. Direct repeat sequences are implicated in the regulation of 2 streptomyces chitinase promoters that are subject to carbon catabolite control Proceedings of the National Academy of Sciences of the United States of America  1992 89:1885-1889  DOI:10.1073/pnas.89.5.1885  PMID:1542688
• Ohashi, T., Boggs, S., Robbins, P., Bahnson, A., Patrene, K., Wei, F. S., Wei, J. F., Li, J., Lucht, L., Fei, Y., Clark, S., Kimak, M., et al. Efficient transfer and sustained high expression of the human glucocerebrosidase gene in mice and their functional macrophages following transplantation of bone-marrow transduced by a retroviral vector Proceedings of the National Academy of Sciences of the United States of America  1992 89:11332-11336  DOI:10.1073/pnas.89.23.11332  PMID:1454816
• Bandara, G., Robbins, P. D., Georgescu, H. I., Mueller, G. M., Glorioso, J. C., Evans, C. H. Gene-transfer to synoviocytes - prospects for gene treatment of arthritis DNA and Cell Biology  1992 11:227-231  DOI:10.1089/dna.1992.11.227  PMID:1567555
• Tahara, H., Mueller, G. M., Ricordi, C., Robbins, P. D., Lotze, M. T. Islet cell transplantation facilitated by gene-transfer Transplantation Proceedings  1992 24:2975-2976  PMID:1466019
• Kim, S. J., Wagner, S., Liu, F., Oreilly, M. A., Robbins, P. D., Green, M. R. Retinoblastoma gene-product activates expression of the human TGF-beta-2 gene through transcription factor ATF-2 Nature  1992 358:331-334  DOI:10.1038/358331a0  PMID:1641004
• Evans, C. H., Bandara, G., Mueller, G., Robbins, P., Glorioso, J. C., Georgescu, H. I. Synovial cell transplants for gene-transfer to joints Transplantation Proceedings  1992 24:2966-2966  PMID:1466016
• Kim, S. J., Onwuta, U. S., Lee, Y. I., Li, R., Botchan, M. R., Robbins, P. D. The retinoblastoma gene-product regulates Sp1-mediated transcription Molecular and Cellular Biology  1992 12:2455-2463  PMID:1588949  PMCID:PMC364438
• Sakai, T., Ohtani, N., McGee, T. L., Robbins, P. D., Dryja, T. P. Oncogenic germ-line mutations in Sp1 and ATF sites in the human retinoblastoma gene Nature  1991 353:83-90  DOI:10.1038/353083a0  PMID:1881452
• Kim, S. J., Lee, H. D., Robbins, P. D., Busam, K., Sporn, M. B. Regulation of transforming growth factor-beta-1 gene-expression by the product of the retinoblastoma-susceptibility gene Proceedings of the National Academy of Sciences of the United States of America  1991 88:3052-3056  DOI:10.1073/pnas.88.8.3052  PMID:1901652
• Robbins, P. D., Horowitz, J. M., Mulligan, R. C. Negative regulation of human c-fos expression by the retinoblastoma gene-product Nature  1990 346:668-671  DOI:10.1038/346668a0  PMID:2117257
• Lenardo, M. J., Staudt, L., Robbins, P., Kuang, A., Mulligan, R. C., Baltimore, D. Repression of the IgH enhancer in teratocarcinoma cells associated with a novel octamer factor Science  1989 243:544-546  DOI:10.1126/science.2536195  PMID:2536195
• Robbins, P. D., Rio, D. C., Botchan, M. R. Trans activation of the simian virus 40 enhancer Molecular and Cellular Biology  1986 6:1283-1295  PMID:3023880  PMCID:PMC367641