recent publications
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academic article
- Chakravarty, A., Reddy, V. S., Rao, A. L. N. Unravelling the stability and capsid dynamics of the three virions of brome mosaic virus assembled autonomously in vivo Journal of Virology 2020 94 DOI:10.1128/jvi.01794-19 PMID:31996436 PMCID:PMC7108849
- Elias, R. D., Ma, W., Ghirlando, R., Schwieters, C. D., Reddy, V. S., Deshmukh, L. Proline-rich domain of human ALIX contains multiple TSG101-UEV interaction sites and forms phosphorylation-mediated reversible amyloids Proceedings of the National Academy of Sciences of the United States of America 2020 117:24274-24284 DOI:10.1073/pnas.2010635117 PMID:32917811 PMCID:PMC7533887
- Natchiar, S. K., Venkataraman, S., Mullen, T. M., Nemerow, G. R., Reddy, V. S. Revised crystal structure of human adenovirus reveals the limits on protein IX quasi-equivalence and on analyzing large macromolecular complexes Journal of Molecular Biology 2018 430:4132-4141 DOI:10.1016/j.jmb.2018.08.011 PMID:30121295
- Matteson, N. L., Barry, M. A., Reddy, V. S. Structure-based assessment of protein-protein interactions and accessibility of protein IX in adenoviruses with implications for antigen display Virology 2018 516:102-107 DOI:10.1016/j.virol.2018.01.007 PMID:29331865
- Ho, P. T., Reddy, V. S. Rapid increase of near atomic resolution virus capsid structures determined by cryo-electron microscopy Journal of Structural Biology 2018 201:1-4 DOI:10.1016/j.jsb.2017.10.007 PMID:29080674
- Ho, P. T., Montiel-Garcia, D. J., Wong, J. J., Carrillo-Tripp, M., Brooks, C. L., Johnson, J. E., Reddy, V. S. VIPERdb: A tool for virus research Annual Review of Virology 2018 5:477-488 DOI:10.1146/annurev-virology-092917-043405 PMID:30265627
- Wagner, C., Reddy, V., Asturias, F., Khoshouei, M., Johnson Jr, J. E., Manrique, P., Munson-McGee, J., Baumeister, W., Lawrence, C. M., Young, M. J. Isolation and characterization of metallosphaera turreted icosahedral virus, a founding member of a new family of archaeal viruses Journal of Virology 2017 91:e00925-17 DOI:10.1128/jvi.00925-17 PMID:28768871 PMCID:PMC5625487
- Reddy, V. S. The role of hexon protein as a molecular mold in patterning the protein IX organization in human adenoviruses Journal of Molecular Biology 2017 429:2747-2751 DOI:10.1016/j.jmb.2017.06.025 PMID:28728980 PMCID:PMC5572314
- Yu, X., Veesler, D., Campbell, M. G., Barry, M. E., Asturias, F. J., Barry, M. A., Reddy, V. S. Cryo-EM structure of human adenovirus D26 reveals the conservation of structural organization among human adenoviruses Science Advances 2017 3 DOI:10.1126/sciadv.1602670 PMID:28508067
- Snijder, J., Borst, A. J., Dosey, A., Walls, A. C., Burrell, A., Reddy, V. S., Kollman, J. M., Veesler, D. Vitrification after multiple rounds of sample application and blotting improves particle density on cryo-electron microscopy grids Journal of Structural Biology 2017 198:38-42 DOI:10.1016/j.jsb.2017.02.008 PMID:28254381 PMCID:PMC5400742
- Montiel-Garcia, D. J., Mannige, R. V., Reddy, V. S., Carrillo-Tripp, M. Structure based sequence analysis of viral and cellular protein assemblies Journal of Structural Biology 2016 196:299-308 DOI:10.1016/j.jsb.2016.07.013 PMID:27480508
- Huynh, N. T., Hesketh, E. L., Saxena, P., Meshcheriakova, Y., Ku, Y. C., Hoang, L. T., Johnson Jr., J. E., Ranson, N. A., Lomonossoff, G. P., Reddy, V. S. Crystal structure and proteomics analysis of empty virus-like particles of cowpea mosaic virus Structure 2016 24:567-575 DOI:10.1016/j.str.2016.02.011 PMID:27021160 PMCID:PMC4828962
- Reddy, V. S. Application of the phase extension method in virus crystallography Crystallography Reviews 2016 22:128-140 DOI:10.1080/0889311x.2015.1065489
- Carrillo-Tripp, M., Montiel-Garcia, D. J., Brooks III, C. L., Reddy, V. S. CapsidMaps: protein-protein interaction pattern discovery platform for the structural analysis of virus capsids using Google Maps Journal of Structural Biology 2015 190:47-55 DOI:10.1016/j.jsb.2015.02.003 PMID:25697908 PMCID:PMC4750372
- Berman, H. M., Gabanyi, M. J., Groom, C. R., Johnson Jr., J. E., Murshudov, G. N., Nicholls, R. A., Reddy, V., Schwede, T., Zimmerman, M. D., Westbrook, J., Minor, W. Data to knowledge: how to get meaning from your result IUCrJ 2015 2:45-58 DOI:10.1107/s2052252514023306 PMID:25610627
- Reddy, V. S., Nemerow, G. R. Reply to Campos: Revised structures of adenovirus cement proteins represent a consensus model for understanding virus assembly and disassembly Proceedings of the National Academy of Sciences of the United States of America 2014 111:E4544-E4545 DOI:10.1073/pnas.1417014111 PMID:25304639 PMCID:PMC4217467
- Reddy, V. S., Nemerow, G. R. Structures and organization of adenovirus cement proteins provide insights into the role of capsid maturation in virus entry and infection Proceedings of the National Academy of Sciences of the United States of America 2014 111:11715-11720 DOI:10.1073/pnas.1408462111 PMID:25071205 PMCID:PMC4136627
- Snijder, J., Benevento, M., Moyer, C. L., Reddy, V., Nemerow, G. R., Heck, A. J. R. The cleaved N-terminus of pVI binds peripentonal hexons in mature adenovirus Journal of Molecular Biology 2014 426:1971-1979 DOI:10.1016/j.jmb.2014.02.022 PMID:24613303 PMCID:PMC4057896
- Benevento, M., Di Palma, S., Snijder, J., Moyer, C. L., Reddy, V. S., Nemerow, G. R., Heck, A. J. R. Adenovirus composition, proteolysis, and disassembly studied by in-depth qualitative and quantitative proteomics Journal of Biological Chemistry 2014 289:11421-11430 DOI:10.1074/jbc.M113.537498 PMID:24591515 PMCID:PMC4036278
- Snijder, J., Reddy, V. S., May, E. R., Roos, W. H., Nemerow, G. R., Wuite, G. J. L. Integrin and defensin modulate the mechanical properties of adenovirus Journal of Virology 2013 87:2756-2766 DOI:10.1128/jvi.02516-12 PMID:23269786 PMCID:PMC3571403
- Nemerow, G. R., Stewart, P. L., Reddy, V. S. Structure of human adenovirus Current Opinion in Virology 2012 2:115-121 DOI:10.1016/j.coviro.2011.12.008 PMID:22482707 PMCID:PMC3322384
- Khare, R., Reddy, V. S., Nemerow, G. R., Barry, M. A. Identification of adenovirus serotype 5 hexon regions that interact with scavenger receptors Journal of Virology 2012 86:2293-2301 DOI:10.1128/jvi.05760-11 PMID:22156515 PMCID:PMC3302413
- Reddy, V. S., Natchiar, S. K., Stewart, P. L., Nemerow, G. R. Crystal structure of human adenovirus at 3.5 Å resolution Science 2010 329:1071-1075 DOI:10.1126/science.1187292 PMID:20798318 PMCID:PMC2929978
- Reddy, V. S., Natchiar, S. K., Gritton, L., Mullen, T. M., Stewart, P. L., Nemerow, G. R. Crystallization and preliminary X-ray diffraction analysis of human adenovirus Virology 2010 402:209-214 DOI:10.1016/j.virol.2010.03.028 PMID:20394956 PMCID:PMC2871957
- Kumar, S., Ochoa, W., Singh, P., Hsu, C., Schneemann, A., Manchester, M., Olson, M., Reddy, V. Tomato bushy stunt virus (TBSV), a versatile platform for polyvalent display of antigenic epitopes and vaccine design Virology 2009 388:185-190 DOI:10.1016/j.virol.2009.02.051 PMID:19344926
- Nguyen, H. D., Reddy, V. S., Brooks, C. L. Invariant polymorphism in virus capsid assembly Journal of the American Chemical Society 2009 131:2606-2614 DOI:10.1021/ja807730x PMID:19199626 PMCID:PMC2768263
- Nemerow, G. R., Pache, L., Reddy, V., Stewart, P. L. Insights into adenovirus host cell interactions from structural studies Virology 2009 384:380-388 DOI:10.1016/j.virol.2008.10.016 PMID:19019405 PMCID:PMC2666334
- Carrillo-Tripp, M., Shepherd, C. M., Borelli, I. A., Venkataraman, S., Lander, G., Natarajan, P., Johnson, J. E., Brooks, C. L., Reddy, V. S. VIPERdb(2): an enhanced and web API enabled relational database for structural virology Nucleic Acids Research 2009 37:D436-D442 DOI:10.1093/nar/gkn840 PMID:18981051 PMCID:PMC2686430
- Carrillo-Tripp, M., Brooks, C. L., Reddy, V. S. A novel method to map and compare protein-protein interactions in spherical viral capsids Proteins-Structure Function and Bioinformatics 2008 73:644-655 DOI:10.1002/prot.22088 PMID:18491385
- Venkataraman, S., Reddy, S. P., Loo, J., Idamakanti, N., Hallenbeck, P. L., Reddy, V. S. Structure of Seneca Valley Virus-001: an oncolytic picornavirus representing a new genus Structure 2008 16:1555-1561 DOI:10.1016/j.str.2008.07.013 PMID:18940610 PMCID:PMC2572565
- Pache, L., Venkataraman, S., Reddy, V. S., Nemerow, G. R. Structural variations in species B adenovirus fibers impact CD46 association Journal of Virology 2008 82:7923-7931 DOI:10.1128/jvi.00754-08 PMID:18524830 PMCID:PMC2519554
- Pache, L., Venkataraman, S., Nemerow, G. R., Reddy, V. S. Conservation of fiber structure and CD46 usage by subgroup B2 adenoviruses Virology 2008 375:573-579 DOI:10.1016/j.virol.2008.02.013 PMID:18336857
- Venkataraman, S., Reddy, S. P., Loo, J., Idamakanti, N., Hallenbeck, P. L., Reddy, V. S. Crystallization and preliminary X-ray diffraction studies of Seneca Valley virus-001, a new member of the Picornaviridae family Acta Crystallographica Section F-Structural Biology and Crystallization Communications 2008 64:293-296 DOI:10.1107/s1744309108006921 PMID:18391430 PMCID:PMC2374260
- Manayani, D. J., Thomas, D., Dryden, K. A., Reddy, V., Siladi, M. E., Marlett, J. M., Rainey, G. J. A., Pique, M. E., Scobie, H. M., Yeager, M., Young, J. A. T., Manchester, M., et al. A viral nanoparticle with dual function as an anthrax antitoxin and vaccine PLoS Pathogens 2007 3:1422-1431 DOI:10.1371/journal.ppat.0030142 PMID:17922572 PMCID:PMC2000967
- Lad, S. P., Yang, G., Scott, D. A., Wang, G., Nair, P., Mathison, J., Reddy, V. S., Li, E. Chlamydial CT441 is a PDZ domain-containing tail-specific protease that interferes with the NF-kappaB pathway of immune response Journal of Bacteriology 2007 189:6619-6625 DOI:10.1128/jb.00429-07 PMID:17631635 PMCID:PMC2045167
- Kumar, S., Ochoa, W., Kobayashi, S., Reddy, V. S. Presence of a surface-exposed loop facilitates trypsinization of particles of Sinsiro virus, a genogroup II.3 norovirus Journal of Virology 2007 81:1119-1128 DOI:10.1128/jvi.01909-06 PMID:17079293 PMCID:PMC1797490
- Hsu, C., Singh, P., Ochoa, W., Manayani, D. J., Manchester, M., Schneemann, A., Reddy, V. S. Characterization of polymorphism displayed by the coat protein mutants of tomato bushy stunt virus Virology 2006 349:222-229 DOI:10.1016/j.virol.2006.02.038 PMID:16603216
- Taylor, D. J., Speir, J. A., Reddy, V., Cingolani, G., Pringle, F. M., Ball, L. A., Johnson, J. E. Preliminary X-ray characterization of authentic providence virus and attempts to express its coat protein gene in recombinant baculovirus Archives of Virology 2006 151:155-165 DOI:10.1007/s00705-005-0637-3 PMID:16211330
- Shepherd, C. M., Borelli, I. A., Lander, G., Natarajan, P., Siddavanahalli, V., Bajaj, C., Johnson, J. E., Brooks, C. L., Reddy, V. S. VIPERdb: a relational database for structural virology Nucleic Acids Research 2006 34:D386-D389 DOI:10.1093/nar/gkj032 PMID:16381893 PMCID:PMC1347395
- Natarajan, P., Lander, G. C., Shepherd, C. M., Reddy, V. S., Brooks, C. L., Johnson, J. E. Exploring icosahedral virus structures with VIPER Nature Reviews Microbiology 2005 3:809-817 DOI:10.1038/nrmicro1247 PMID:16205712
- Shepherd, C. M., Reddy, V. S. Extent of protein-protein interactions and quasi-equivalence in viral capsids Proteins-Structure Function and Bioinformatics 2005 58:472-477 DOI:10.1002/prot.20311 PMID:15558545
- Damodaran, K. V., Reddy, V. S., Johnson, J. E., Brooks, C. L. A general method to quantify quasi-equivalence in icosahedral viruses Journal of Molecular Biology 2002 324:723-737 DOI:10.1016/s0022-2836(02)01138-5 PMID:12460573
- Ren, G., Reddy, V. S., Cheng, A., Melnyk, P., Mitra, A. K. Visualization of a water-selective pore by electron crystallography in vitreous ice Proceedings of the National Academy of Sciences of the United States of America 2001 98:1398-1403 DOI:10.1073/pnas.041489198 PMID:11171962 PMCID:PMC29268
- Sousa, M. C., Trame, C. B., Tsuruta, H., Wilbanks, S. M., Reddy, V. S., McKay, D. B. Crystal and solution structures of an HslUV protease-chaperone complex Cell 2000 103:633-643 DOI:10.1016/s0092-8674(00)00166-5 PMID:11106733
- Oliveira, A. C., Gomes, A. M. O., Almeida, F. C. L., Mohana-Borges, R., Valente, A. P., Reddy, V. S., Johnson, J. E., Silva, J. L. Virus maturation targets the protein capsid to concerted disassembly and unfolding Journal of Biological Chemistry 2000 275:16037-16043 DOI:10.1074/jbc.M910145199 PMID:10748191
- Huang, S., Reddy, V., Dasgupta, N., Nemerow, G. R. A single amino acid in the adenovirus type 37 fiber confers binding to human conjunctival cells Journal of Virology 1999 73:2798-2802 PMID:10074127 PMCID:PMC104037
- Padidam, M., Reddy, V. S., Beachy, R. N., Fauquet, C. M. Molecular characterization of a plant mitochondrial chaperone GrpE Plant Molecular Biology 1999 39:871-881 DOI:10.1023/a:1006143305907 PMID:10344193
- Bothner, B., Schneemann, A., Marshall, D., Reddy, V., Johnson, J. E., Siuzdak, G. Crystallographically identical virus capsids display different properties in solution Nature Structural Biology 1999 6:114-116 PMID:10048920
- Tsuruta, H., Reddy, V. S., Wikoff, W. R., Johnson, J. E. Imaging RNA and dynamic protein segments with low-resolution virus crystallography: experimental design, data processing and implications of electron density maps Journal of Molecular Biology 1998 284:1439-1452 DOI:10.1006/jmbi.1998.2231 PMID:9878362
- Johnson, J. E., Reddy, V. S. Biggest virus molecular structure yet! Nature Structural Biology 1998 5:849-854 DOI:10.1038/2288 PMID:9783739
- Reddy, V. S., Giesing, H. A., Morton, R. T., Kumar, A., Post, C. B., Brooks, C. L., Johnson, J. E. Energetics of quasiequivalence: computational analysis of protein-protein interactions in icosahedral viruses Biophysical Journal 1998 74:546-558 DOI:10.1016/S0006-3495(98)77813-0 PMID:9449355 PMCID:PMC1299407
- Schneemann, A., Reddy, V., Johnson, J. E. The structure and function of nodavirus particles: a paradigm for understanding chemical biology Advances in Virus Research 1998 50:381-446 DOI:10.1016/s0065-3527(08)60812-x PMID:9521003
- Kumar, A., Reddy, V. S., Yusibov, V., Chipman, P. R., Hata, Y., Fita, I., Fukuyama, K., Rossmann, M. G., LoeschFries, L. S., Baker, T. S., Johnson, J. E. The structure of alfalfa mosaic virus capsid protein assembled as a T=1 icosahedral particle at 4.0-Å resolution Journal of Virology 1997 71:7911-7916 PMID:9311881 PMCID:PMC192148
- Munshi, S., Liljas, L., Cavarelli, J., Bomu, W., McKinney, B., Reddy, V., Johnson, J. E. The 2.8 Å structure of a T=4 animal virus and its implications for membrane translocation of RNA Journal of Molecular Biology 1996 261:1-10 DOI:10.1006/jmbi.1996.0437 PMID:8760498
- Zlotnick, A., Reddy, V. S., Dasgupta, R., Schneemann, A., Ray, W. J., Rueckert, R. R., Johnson, J. E. Capsid assembly in a family of animal viruses primes an autoproteolytic maturation that depends on a single aspartic acid residue Journal of Biological Chemistry 1994 269:13680-13684 PMID:8175803
- Cheng, R. H., Reddy, V. S., Olson, N. H., Fisher, A. J., Baker, T. S., Johnson, J. E. Functional implications of quasi-equivalence in a T=3 icosahedral animal virus established by cryo-electron microscopy and X-ray crystallography Structure 1994 2:271-282 PMID:8087554
- Wery, J. P., Reddy, V. S., Hosur, M. V., Johnson, J. E. The refined three-dimensional structure of an insect virus at 2.8-Å resolution Journal of Molecular Biology 1994 235:565-586 DOI:10.1006/jmbi.1994.1014 PMID:8289282
- Johnson, J. E., Munshi, S., Liljas, L., Agrawal, D., Olson, N. H., Reddy, V., Fisher, A., McKinney, B., Schmidt, T., Baker, T. S. Comparative studies of T=3 and T=4 icosahedral RNA insect viruses Archives of Virology 1994 497-512 PMID:8032278 PMCID:PMC4167711
- Reddy, V. S., Rao, V. S. R. Modes of binding of alpha(1-2) linked manno-oligosaccharides to concanavalin A International Journal of Biological Macromolecules 1992 14:185-192 DOI:10.1016/s0141-8130(05)80025-x PMID:1504037
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chapter
- Reddy, V. S., Natarajan, P., Lander, G., Qu, C., Brooks, C. L., Johnson, J. E. Virus Particle Explorer (VIPER): a repository of virus capsid structures Conformational Proteomics of Macromolecular Architecture. 403-412. 2004