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Rader, Christoph
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Rader, Christoph

Faculty Member
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Positions

  • 2019 - Professor, Immunology and Microbiology , Scripps Research
  • 2018 - Associate Dean, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2012 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2017 - 2019 Associate Professor, Immunology and Microbiology , Scripps Research
  • 2017 - 2019 Associate Professor, Molecular Medicine , Scripps Research
  • 2012 - 2017 Associate Professor with tenure, Cancer Biology , Scripps Research
  • 2012 - 2017 Associate Professor (Joint Appointment), Molecular Therapeutics , Scripps Research
  • 2003 - 2012 Senior Scientist and Head of the Antibody Technology Section, Experimental Transplantation and Immunology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health
  • 1999 - 2003 Assistant Professor, Molecular Biology , Scripps Research
  • 1996 - 1999 Research Associate with Dr. Carlos F. Barbas, Molecular Biology , Scripps Research
The Rader Laboratory develops and applies technologies for antibody drug and target discovery in cancer.

Research Areas research areas

  • Cancer (UMLS)

Contact

  • crader@scripps.edu

Websites

  • Christoph Rader, Ph.D.
  • Laboratory Website
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Publications

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    • Hu, E. Y., Do, P., Goswami, S., Nunes, J., Chiang, C. L., Elgamal, S., Ventura, A. M., Cheney, C., Zapolnik, K., Williams, E., Mani, R., Frissora, F., et al. The ROR1 antibody-drug conjugate huXBR1-402-G5-PNU effectively targets ROR1(+) leukemia Blood Advances  2021 5:3152-3162  DOI:10.1182/bloodadvances.2020003276  PMID:34424320  PMCID:PMC8405197
    • Lin, C. W., Zheng, T. Q., Grande, G., Nanna, A. R., Rader, C., Lerner, R. A. A new immunochemical strategy for triple-negative breast cancer therapy Scientific Reports  2021 11  DOI:10.1038/s41598-021-94230-4  PMID:34290315  PMCID:PMC8295383
    • Goydel, R. S., Rader, C. Antibody-based cancer therapy Oncogene  2021 40:3655-3664  DOI:10.1038/s41388-021-01811-8  PMID:33947958  PMCID:PMC8357052
    • Mou, H. H., Quinlan, B. D., Peng, H. Y., Liu, G. Q., Guo, Y., Peng, S. J., Zhang, L. Z., Davis-Gardner, M. E., Gardner, M. R., Crynen, G., DeVaux, L. B., Voo, Z. X., et al. Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2 PLoS Pathogens  2021 17  DOI:10.1371/journal.ppat.1009501  PMID:33836016  PMCID:PMC8059821
    • Nilchan, N., Alburger, J. M., Roush, W. R., Rader, C. An Engineered Arginine Residue of Unusual pH-Sensitive Reactivity Facilitates Site-Selective Antibody Conjugation Biochemistry  2021 60:1080-1087  DOI:10.1021/acs.biochem.0c00955  PMID:33754696
    • Kovalovsky, D., Yoon, J. H., Cyr, M. G., Simon, S., Voynova, E., Rader, C., Wiestner, A., Alejo, J., Pittaluga, S., Gress, R. E. Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia Leukemia  2021  DOI:10.1038/s41375-021-01188-3  PMID:33633313
    • Bhoj, V. G., Li, L., Parvathaneni, K., Zhang, Z., Kacir, S., Arhontoulis, D., Zhou, K., McGettigan-Croce, B., Nunez-Cruz, S., Gulendran, G., Boesteanu, A. C., Johnson, L., et al. Adoptive T cell immunotherapy for medullary thyroid carcinoma targeting GDNF family receptor alpha 4 Molecular Therapy-Oncolytics  2021 20:387-398  DOI:10.1016/j.omto.2021.01.012  PMID:33614919  PMCID:PMC7879023
    • Mhibik, M., Gaglione, E. M., Eik, D., Kendall, E. K., Blackburn, A., Keyvanfar, K., Baptista, M. J., Ahn, I. E., Sun, C., Qi, J. P., Rader, C., Wiestner, A. BTK inhibitors, irrespective of ITK inhibition, increase efficacy of a CD19/CD3-bispecific antibody in CLL Blood  2021 138:1843-1854  DOI:10.1182/blood.2020009686  PMID:34046681  PMCID:PMC8586964
    • Srivastava, S., Furlan, S. N., Jaeger-Ruckstuhl, C. A., Sarvothama, M., Berger, C., Smythe, K. S., Garrison, S. M., Specht, J. M., Lee, S. M., Amezquita, R. A., Voillet, V., Muhunthan, V., et al. Immunogenic Chemotherapy Enhances Recruitment of CAR-TCells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade Cancer Cell  2020 39:193-208  DOI:10.1016/j.ccell.2020.11.005  PMID:33357452  PMCID:PMC7878409
    • Qi, J. P., Rader, C. Redirecting cytotoxic T cells with chemically programmed antibodies Bioorganic & Medicinal Chemistry  2020 28  DOI:10.1016/j.bmc.2020.115834  PMID:33166926
    • Adhikari, A., Teijaro, C. N., Yan, X. H., Chang, C. Y., Gui, C., Liu, Y. C., Crnovcic, I., Yang, D., Annaval, T., Rader, C., Shen, B. Characterization of TnmH as an O-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates Journal of Medicinal Chemistry  2020 63:8432-8441  DOI:10.1021/acs.jmedchem.0c00799  PMID:32658465  PMCID:PMC7461649
    • Qi, J. P., Tsuji, K., Hymel, D., Burke, T. R., Hudecek, M., Rader, C., Peng, H. Chemically Programmable and Switchable CAR-T Therapy Angewandte Chemie-International Edition  2020  DOI:10.1002/anie.202005432  PMID:32329959
    • Nanna, A. R., Kel'in, A. V., Theile, C., Pierson, J. M., Voo, Z. X., Garg, A., Nair, J. K., Maier, M. A., Fitzgerald, K., Rader, C. Generation and validation of structurally defined antibody-siRNA conjugates Nucleic Acids Research  2020 48:5281-5293  DOI:10.1093/nar/gkaa286  PMID:32347936  PMCID:PMC7261152
    • Goydel, R. S., Weber, J., Peng, H. Y., Qi, J. P., Soden, J., Freeth, J., Park, H., Rader, C. Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications Journal of Biological Chemistry  2020 295:5995-6006  DOI:10.1074/jbc.RA120.012791  PMID:32193207  PMCID:PMC7196640
    • Hwang, D., Rader, C. Site-Specific Antibody-Drug Conjugates in Triple Variable Domain Fab Format Biomolecules  2020 10  DOI:10.3390/biom10050764  PMID:32422893  PMCID:PMC7278019
    • Rader, C. Bispecific antibodies in cancer immunotherapy Current Opinion in Biotechnology  2019 65:9-16  DOI:10.1016/j.copbio.2019.11.020  PMID:31841859  PMCID:PMC7292752
    • Hwang, D., Tsuji, K., Park, H., Burke, T. R., Rader, C. Site-specific lysine arylation as an alternative bioconjugation strategy for chemically programmed antibodies and antibody-drug conjugates Bioconjugate Chemistry  2019 30:2889-2896  DOI:10.1021/acs.bioconjchem.9b00609  PMID:31675216
    • Hwang, D.*, Nilchan, N.*, Nanna, A. R., Li, X., Cameron, M. D., Roush, W. R., Park, H., Rader, C. Site-selective antibody functionalization via orthogonally reactive arginine and lysine residues Cell Chemical Biology  2019 26:1229-1239  DOI:10.1016/j.chembiol.2019.05.010  PMID:31231031  PMCID:PMC6754284 (* = equal contribution)
    • Rader, C., Wiestner, A. Six-packed antibodies punch better Haematologica  2019 104:1696-1699  DOI:10.3324/haematol.2019.224196  PMID:31473607  PMCID:PMC6717577
    • Qi, J., Hymel, D., Nelson, C. G., Burke Jr., T. R., Rader, C. Conventional and chemically programmed asymmetric bispecific antibodies targeting folate receptor 1 Frontiers in Immunology  2019 10  DOI:10.3389/fimmu.2019.01994  PMCID:PMC6712926
    • Chiang, C. L., Goswami, S., Frissora, F. W., Xie, Z., Yan, P. S., Bundschuh, R., Walker, L. A., Huang, X. M., Mani, R., Mo, X. K. M., Baskar, S., Rader, C., et al. ROR1-targeted delivery of miR-29b induces cell cycle arrest and therapeutic benefit in vivo in a CLL mouse model Blood  2019 134:432-444  DOI:10.1182/blood.2018882290  PMID:31151986
    • Srivastava, S., Salter, A. I., Liggitt, D., Yechan-Gunja, S., Sarvothama, M., Cooper, K., Smythe, K. S., Dudakov, J. A., Pierce, R. H., Rader, C., Ridde, S. R. Logic-gated ROR1 chimeric antigen receptor expression rescues T cell-mediated toxicity to normal tissues and enables selective tumor targeting Cancer Cell  2019 35:489-503  DOI:10.1016/j.ccell.2019.02.003  PMID:30889382  PMCID:PMC6450658
    • Mage, R. G., Esteves, P. J., Rader, C. Rabbit models of human diseases for diagnostics and therapeutics development Developmental and Comparative Immunology  2019 92:99-104  DOI:10.1016/j.dci.2018.10.003  PMID:30339876  PMCID:PMC6364550
    • Rydzek, J., Nerreter, T., Peng, H., Jutz, S., Leitner, J., Steinberger, P., Einsele, H., Rader, C., Hudecek, M. Chimeric antigen receptor library screening using a novel NF-κB/NFAT reporter cell platform Molecular Therapy  2019 27:287-299  DOI:10.1016/j.ymthe.2018.11.015  PMID:30573301  PMCID:PMC6369451
    • Qi, J., Chen, S. S., Chiorazzi, N., Rader, C. An IgG1-like bispecific antibody targeting CD52 and CD20 for the treatment of B-cell malignancies Methods  2019 154:70-76  DOI:10.1016/j.ymeth.2018.08.008  PMID:30145356
    • Wilson, H. D., Li, X., Peng, H., Rader, C. A sortase a programmable phage display format for improved panning of Fab antibody libraries Journal of Molecular Biology  2018 430:4387-4400  DOI:10.1016/j.jmb.2018.09.003  PMID:30213726  PMCID:PMC6186506
    • Yan, X., Chen, J. J., Adhikari, A., Teijaro, C. N., Ge, H., Crnovcic, I., Chang, C. Y., Annaval, T., Yang, D., Rader, C., Shen, B. Comparative studies of the biosynthetic gene clusters for anthraquinone-fused enediynes shedding light into the tailoring steps of tiancimycin biosynthesis Organic Letters  2018 20:5918-5921  DOI:10.1021/acs.orglett.8b02584  PMID:30212211
    • Chang, J., Peng, H., Shaffer, B. C., Baskar, S., Wecken, I. C., Cyr, M. G., Martinez, G. J., Soden, J., Freeth, J., Wiestner, A., Rader, C. Siglec-6 on chronic lymphocytic leukemia cells is a target for post-allogeneic hematopoietic stem cell transplantation antibodies Cancer Immunology Research  2018 6:1008-1013  DOI:10.1158/2326-6066.cir-18-0102  PMID:29980538  PMCID:PMC6125214
    • Robinson, H. R., Qi, J., Cook, E. M., Nichols, C., Dadashian, E. L., Underbayev, C., Herman, S. E. M., Saba, N. S., Keyvanfar, K., Sun, C., Ahn, I. E., Baskar, S., et al. A CD19/CD3 bispecific antibody for effective immunotherapy of chronic lymphocytic leukemia in the ibrutinib era Blood  2018 132:521-532  DOI:10.1182/blood-2018-02-830992  PMID:29743179  PMCID:PMC6073325
    • Qi, J., Li, X., Peng, H., Cook, E. M., Dadashian, E. L., Wiestner, A., Park, H., Rader, C. Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1 Proceedings of the National Academy of Sciences of the United States of America  2018 115:E5467-E5476  DOI:10.1073/pnas.1719905115  PMID:29844189
    • Yan, X., Chen, J. J., Adhikari, A., Yang, D., Crnovcic, I., Wang, N., Chang, C. Y., Rader, C., Shen, B. Genome mining of micromonospora yangpuensis DSM 45577 as a producer of an anthraquinone-fused enediyne Organic Letters  2017 19:6192-6195  DOI:10.1021/acs.orglett.7b03120  PMID:29086572
    • Nanna, A. R., Li, X., Walseng, E., Pedzisa, L., Goydel, R. S., Hymel, D., Burke, T. R., Roush, W. R., Rader, C. Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates Nature Communications  2017 8  DOI:10.1038/s41467-017-01257-1  PMID:29062027  PMCID:PMC5653646
    • Zhuang, X., Watts, N. R., Palmer, I. W., Kaufman, J. D., Dearborn, A. D., Trenbeath, J. L., Eren, E., Steven, A. C., Rader, C., Wingfield, P. T. Chimeric rabbit/human Fab antibodies against the hepatitis Be-antigen and their potential applications in assays, characterization, and therapy Journal of Biological Chemistry  2017 292:16760-16772  DOI:10.1074/jbc.M117.802272  PMID:28842495  PMCID:PMC5633136
    • Peng, H., Nerreter, T., Chang, J., Qi, J., Li, X., Karunadharma, P., Martinez, G. J., Fallahi, M., Soden, J., Freeth, J., Beerli, R. R., Grawunder, U., et al. Mining naive rabbit antibody repertoires by phage display for monoclonal antibodies of therapeutic utility Journal of Molecular Biology  2017 429:2954-2973  DOI:10.1016/j.jmb.2017.08.003  PMID:28818634  PMCID:PMC5610937
    • Li, X., Nelson, C. G., Nair, R. R., Hazlehurst, L., Moroni, T., Martinez-Acedo, P., Nanna, A. R., Hymel, D., Burke, T. R., Rader, C. Stable and potent selenomab-drug conjugates Cell Chemical Biology  2017 24:433-442  DOI:10.1016/j.chembiol.2017.02.012  PMID:28330604  PMCID:PMC5400723
    • Moreadith, R. W., Viegas, T. X., Bentley, M. D., Harris, J. M., Fang, Z., Yoon, K., Dizman, B., Weimer, R., Rae, B. P., Li, X., Rader, C., Standaert, D., et al. Clinical development of a poly(2-oxazoline) (POZ) polymer therapeutic for the treatment of Parkinson's disease - Proof of concept of POZ as a versatile polymer platform for drug development in multiple therapeutic indications European Polymer Journal  2017 88:524-552  DOI:10.1016/j.eurpolymj.2016.09.052
    • Weber, J., Peng, H., Rader, C. From rabbit antibody repertoires to rabbit monoclonal antibodies Experimental and Molecular Medicine  2017 49  DOI:10.1038/emm.2017.23  PMID:28336958  PMCID:PMC5382564
    • Yan, X., Ge, H., Huang, T., Hindra, Yang, D., Teng, Q., Crnovcic, I., Li, X., Rudolf, J. D., Lohman, J. R., Gansemans, Y., Zhu, X., et al. Strain prioritization and genome mining for enediyne natural products MBio  2016 7  DOI:10.1128/mBio.02104-16  PMID:27999165  PMCID:PMC5181780
    • Patterson, J. T., Wilson, H. D., Asano, S., Nilchan, N., Fuller, R. P., Roush, W. R., Rader, C., Barbas III, C. F. Human serum albumin domain I fusion protein for antibody conjugation Bioconjugate Chemistry  2016 27:2271-2275  DOI:10.1021/acs.bioconjchem.6b00432  PMID:27666414
    • Walseng, E., Nelson, C. G., Qi, J., Nanna, A. R., Roush, W. R., Goswami, R. K., Sinha, S. C., Burke Jr., T. R., Rader, C. Chemically programmed bispecific antibodies in diabody format Journal of Biological Chemistry  2016 291:19661-19673  DOI:10.1074/jbc.M116.745588  PMID:27445334  PMCID:PMC5016699
    • Li, W., Li, X., Huang, T., Teng, Q., Crnovcic, I., Rader, C., Shen, B. Engineered production of cancer targeting peptide (CTP)-containing C-1027 in Streptomyces globisporus and biological evaluation Bioorganic & Medicinal Chemistry  2016 24:3887-3892  DOI:10.1016/j.bmc.2016.04.017  PMID:27094150  PMCID:PMC4972678
    • Gnaim, S., Scomparin, A., Li, X., Baran, P. S., Rader, C., Satchi-Fainaro, R., Shabat, D. Tagging the untaggable: a difluoroalkyl-sulfinate ketone-based reagent for direct C-H functionalization of bioactive heteroarenes Bioconjugate Chemistry  2016 27:1965-1971  DOI:10.1021/acs.bioconjchem.6b00382  PMID:27494153
    • Pedzisa, L., Li, X., Rader, C., Roush, W. R. Assessment of reagents for selenocysteine conjugation and the stability of selenocysteine adducts Organic & Biomolecular Chemistry  2016 14:5141-5147  DOI:10.1039/c6ob00775a  PMID:27184239  PMCID:PMC4887430
    • Sarkar, M., Liu, Y., Qi, J., Peng, H., Morimoto, J., Rader, C., Chiorazzi, N., Kodadek, T. Targeting stereotyped B cell receptors from chronic lymphocytic leukemia patients with synthetic antigen surrogates Journal of Biological Chemistry  2016 291:7558-7570  DOI:10.1074/jbc.M115.701656  PMID:26851280  PMCID:PMC4817184
    • Li, X., Patterson, J. T., Sarkar, M., Pedzisa, L., Kodadek, T., Roush, W. R., Rader, C. Site-specific dual antibody conjugation via engineered cysteine and selenocysteine residues Bioconjugate Chemistry  2015 26:2243-2248  DOI:10.1021/acs.bioconjchem.5600244  PMID:26161903
    • Ma, M., Rateb, M. E., Teng, Q., Yang, D., Rudolf, J. D., Zhu, X., Huang, Y., Zhao, L. X., Jiang, Y., Li, X., Rader, C., Duan, Y., et al. Angucyclines and angucyclinones from streptomyces sp. CB01913 featuring C-ring cleavage and expansion Journal of Natural Products  2015 78:2471-2480  DOI:10.1021/acs.jnatprod.5b00601  PMID:26335269  PMCID:PMC4845661
    • Mani, R., Chiang, C. L., Frissora, F. W., Yan, R., Mo, X., Baskar, S., Rader, C., Klisovic, R., Phelps, M. A., Chen, C. S., Lee, R. J., Byrd, J. C., et al. ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo Experimental Hematology  2015 43:770-774  DOI:10.1016/j.exphem.2015.04.008  PMID:25937048
    • Huang, X., Park, H., Greene, J., Pao, J., Mulvey, E., Zhou, S. X., Albert, C. M., Moy, F., Sachdev, D., Yee, D., Rader, C., Hamby, C. V., et al. IGF1R-and ROR1-specific CAR T cells as a potential therapy for high risk sarcomas PLoS One  2015 10:e0133152  DOI:10.1371/journal.pone.0133152  PMID:26173023  PMCID:PMC4501840
    • Chinthalapudi, K., Patil, D. N., Rangarajan, E. S., Rader, C., Izard, T. Lipid-directed vinculin dimerization Biochemistry  2015 54:2758-2768  DOI:10.1021/acs.biochem.5b00015  PMID:25880222
    • Rader, C. How to minimalize antibodies Nature  2015 518:38-39  PMID:25652990
    • Berger, C., Sommermeyer, D., Hudecek, M., Berger, M., Balakrishnan, A., Paszkiewicz, P. J., Kosasih, P. L., Rader, C., Riddell, S. R. Safety of targeting ROR1 in primates with chimeric antigen receptor-modified T cells Cancer Immunology Research  2015 3:206-216  DOI:10.1158/2326-6066.cir-14-0163  PMID:25355068  PMCID:PMC4324006
    • Hudecek, M., Sommermeyer, D., Kosasih, P. L., Silva-Benedict, A., Liu, L., Rader, C., Jensen, M. C., Riddell, S. R. The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity Cancer Immunology Research  2015 3:125-135  DOI:10.1158/2326-6066.cir-14-0127  PMID:25212991
    • Mani, R., Mao, Y., Frissora, F. W., Chiang, C. L., Wang, J., Zhao, Y., Wu, Y., Yu, B., Yan, R., Mo, X., Yu, L., Flynn, J., et al. Tumor antigen ROR1 targeted drug delivery mediated selective leukemic but not normal B-cell cytotoxicity in chronic lymphocytic leukemia Leukemia  2015 29:346-355  DOI:10.1038/leu.2014.199  PMID:24947019  PMCID:PMC4272672
    • Sarkar, M., Liu, Y., Morimoto, J., Peng, H., Aquino, C., Rader, C., Chiorazzi, N., Kodadek, T. Recognition of antigen-specific B-cell receptors from chronic lymphocytic leukemia patients by synthetic antigen surrogates Chemistry & Biology  2014 21:1670-1679  DOI:10.1016/j.chembiol.2014.10.010  PMID:25467125  PMCID:PMC4272629
    • Vire, B., Skarzynski, M., Thomas, J. D., Nelson, C. G., David, A., Aue, G., Burke Jr., T. R., Rader, C., Wiestner, A. Harnessing the fcμ receptor for potent and selective cytotoxic therapy of chronic lymphocytic leukemia Cancer Research  2014 74:7510-7520  DOI:10.1158/0008-5472.can-14-2030  PMID:25344228  PMCID:PMC4268434
    • Rader, C., Segal, D. J., Shabat, D. Carlos F. Barbas III (1964-2014): Visionary at the interface of chemistry and biology ACS Chemical Biology  2014 9:1645-1646  DOI:10.1021/cb5005993  PMID:25123302
    • Patterson, J. T., Asano, S., Li, X., Rader, C., Barbas III, C. F. Improving the serum stability of site-specific antibody conjugates with sulfone linkers Bioconjugate Chemistry  2014 25:1402-1407  DOI:10.1021/bc500276m  PMID:25099687  PMCID:PMC4140540
    • Gronwall, C., Charles, E. D., Dustin, L. B., Rader, C., Silverman, G. J. Selection of apoptotic cell specific human antibodies from adult bone marrow PLoS One  2014 9:e95999  DOI:10.1371/journal.pone.0095999  PMID:24760047  PMCID:PMC3997490
    • Rader, Christoph Chemically programmed antibodies Trends in Biotechnology  2014 32:186-197  DOI:10.1016/j.tibtech.2014.02.003  PMID:24630478  PMCID:PMC3978777
    • Li, X., Yang, J., Rader, C. Antibody conjugation via one and two C-terminal selenocysteines Methods  2014 65:133-138  DOI:10.1016/j.ymeth.2013.05.023  PMID:23756202  PMCID:PMC3871924
    • Hudecek, M., Lupo-Stanghellini, M. T., Kosasih, P. L., Sommermeyer, D., Jensen, M. C., Rader, C., Riddell, S. R. Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells Clinical Cancer Research  2013 19:3153-3164  DOI:10.1158/1078-0432.ccr-13-0330  PMID:23620405
    • Dave, H., Anver, M. R., Butcher, D. O., Brown, P., Khan, J., Wayne, A. S., Baskar, S., Rader, C. Restricted cell surface expression of receptor tyrosine kinase ROR1 in pediatric B-lineage acute lymphoblastic leukemia suggests targetability with therapeutic monoclonal antibodies PLoS One  2012 7:e52655  DOI:10.1371/journal.pone.0052655  PMID:23285131  PMCID:PMC3527582
    • Thomas, J. D., Cui, H. T., North, P. J., Hofer, T., Rader, C., Burke, T. R. Application of strain-promoted azide-alkyne cycloaddition and tetrazine ligation to targeted Fc-drug conjugates Bioconjugate Chemistry  2012 23:2007-2013  DOI:10.1021/bc300052u  PMID:22988967  PMCID:PMC3474869
    • Cui, H. T., Thomas, J. D., Burke, T. R., Rader, C. Chemically programmed bispecific antibodies that recruit and activate T cells Journal of Biological Chemistry  2012 287:28206-28214  DOI:10.1074/jbc.M112.384594  PMID:22761439  PMCID:PMC3436515
    • Baskar, S., Wiestner, A., Wilson, W. H., Pastan, I., Rader, C. Targeting malignant B cells with an immunotoxin against ROR1 MAbs  2012 4:349-361  DOI:10.4161/mabs.19870  PMID:22531447  PMCID:PMC3355487
    • Yang, J., Rader, C. Cloning, expression, and purification of monoclonal antibodies in scFv-Fc format Methods in Molecular Biology  2012 901:209-232  DOI:10.1007/978-1-61779-931-0_14  PMID:22723104
    • Rader, C. Generation of human Fab libraries for phage display Methods in Molecular Biology  2012 901:53-79  DOI:10.1007/978-1-61779-931-0_4  PMID:22723094
    • Rader, C. Selection of human Fab libraries by phage display Methods in Molecular Biology  2012 901:81-99  DOI:10.1007/978-1-61779-931-0_5  PMID:22723095
    • Yang, J. H., Baskar, S., Kwong, K. Y., Kennedy, M. G., Wiestner, A., Rader, C. Therapeutic potential and challenges of targeting receptor tyrosine kinase ROR1 with monoclonal antibodies in B-cell malignancies PLoS One  2011 6:e21018  DOI:10.1371/journal.pone.0021018  PMID:21698301  PMCID:PMC3115963
    • Bagnara, D., Kaufman, M. S., Calissano, C., Marsilio, S., Patten, P. E. M., Simone, R., Chum, P., Yan, X. J., Allen, S. L., Kolitz, J. E., Baskar, S., Rader, C., et al. A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease Blood  2011 117:5463-5472  DOI:10.1182/blood-2010-12-324210  PMID:21385850  PMCID:PMC3109718
    • Ho, M., Feng, M. Q., Fisher, R. J., Rader, C., Pastan, I. A novel high-affinity human monoclonal antibody to mesothelin International Journal of Cancer  2011 128:2020-2030  DOI:10.1002/ijc.25557  PMID:20635390  PMCID:PMC2978266
    • Rader, C. DARTs take aim at BiTEs Blood  2011 117:4403-4404  PMID:21527536
    • Perez-Galan, P., Mora-Jensen, H., Weniger, M. A., Shaffer, A. L., Rizzatti, E. G., Chapman, C. M., Mo, C. C., Stennett, L. S., Rader, C., Liu, P. C., Raghavachari, N., Stetler-Stevenson, M., et al. Bortezomib resistance in mantle cell lymphoma is associated with plasmacytic differentiation Blood  2011 117:542-552  DOI:10.1182/blood-2010-02-269514  PMID:20956803  PMCID:PMC3031479
    • Andris-Widhopf, J., Steinberger, P., Fuller, R., Rader, C., Barbas III, C. F. Generation of human Fab antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences Cold Spring Harbor Protocols  2011 2011  DOI:10.1101/pdb.prot065565  PMID:21880817
    • Andris-Widhopf, J., Steinberger, P., Fuller, R., Rader, C., Barbas III, C. F. Generation of human scFv antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences Cold Spring Harbor Protocols  2011 2011  DOI:10.1101/pdb.prot065573  PMID:21880816
    • Hudecek, M., Schmitt, T. M., Baskar, S., Lupo-Stanghellini, M. T., Nishida, T., Yamamoto, T. N., Bleakley, M., Turtle, C. J., Chang, W. C., Greisman, H. A., Wood, B., Maloney, D. G., et al. The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor Blood  2010 116:4532-4541  DOI:10.1182/blood-2010-05-283309  PMID:20702778  PMCID:PMC2996114
    • Beerli, R. R., Rader, C. Mining human antibody repertoires MAbs  2010 2:365-378  DOI:10.4161/mabs.2.4.12187  PMID:20505349  PMCID:PMC3180084
    • Stahl, S. J., Watts, N. R., Rader, C., DiMattia, M. A., Mage, R. G., Palmer, I., Kaufman, J. D., Grimes, J. M., Stuart, D. I., Steven, A. C., Wingfield, P. T. Generation and characterization of a chimeric rabbit/human Fab for co-crystallization of HIV-1 Rev Journal of Molecular Biology  2010 397:697-708  DOI:10.1016/j.jmb.2010.01.061  PMID:20138059  PMCID:PMC2851401
    • Lapalombella, R., Andritsos, L., Liu, Q., May, S. E., Browning, R., Pham, L. V., Blum, K. A., Blum, W., Ramanunni, A., Raymond, C. A., Smith, L. L., Lehman, A., et al. Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase-dependent pathway Blood  2010 115:2619-2629  DOI:10.1182/blood-2009-09-242438  PMID:19965642  PMCID:PMC2852364
    • DiMattia, M. A., Watts, N. R., Stahl, S. J., Rader, C., Wingfield, P. T., Stuart, D. I., Steven, A. C., Grimes, J. M. Implications of the HIV-1 Rev dimer structure at 3.2 Å resolution for multimeric binding to the Rev response element Proceedings of the National Academy of Sciences of the United States of America  2010 107:5810-5814  DOI:10.1073/pnas.0914946107  PMID:20231488  PMCID:PMC2851902
    • Salerno, E., Yuan, Y., Scaglione, B. J., Marti, G., Jankovic, A., Mazzella, F., Laurindo, M. F., Despres, D., Baskar, S., Rader, C., Raveche, E. The New Zealand black mouse as a model for the development and progression of chronic lymphocytic leukemia Cytometry Part B-Clinical Cytometry  2010 78B:S98-S109  DOI:10.1002/cyto.b.20544  PMID:20839343  PMCID:PMC2963456
    • Hofer, T., Skeffington, L. R., Chapman, C. M., Rader, C. Molecularly defined antibody conjugation through a selenocysteine interface Biochemistry  2009 48:12047-12057  DOI:10.1021/bi901744t  PMID:19894757  PMCID:PMC2825887
    • Baskar, S., Suschak, J. M., Samija, I., Srinivasan, R., Childs, R. W., Pavletic, S. Z., Bishop, M. R., Rader, C. A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display Blood  2009 114:4494-4502  DOI:10.1182/blood-2009-05-222786  PMID:19667400  PMCID:PMC2777128
    • Derfuss, T., Parikh, K., Velhin, S., Braun, M., Mathey, E., Krumbholz, M., Kumpfel, T., Moldenhauer, A., Rader, C., Sonderegger, P., Pollmann, W., Tiefenthaller, C., et al. Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals Proceedings of the National Academy of Sciences of the United States of America  2009 106:8302-8307  DOI:10.1073/pnas.0901496106  PMID:19416878  PMCID:PMC2688870
    • Robak, L. A., Venkatesh, K., Lee, H., Raiker, S. J., Duan, Y., Lee-Osbourne, J., Hofer, T., Mage, R. G., Rader, C., Giger, R. J. Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition Journal of Neuroscience  2009 29:5768-5783  DOI:10.1523/jneurosci.4935-08.2009  PMID:19420245  PMCID:PMC2779053
    • Kwong, K. Y., Rader, C. E. coli expression and purification of Fab antibody fragments Current Protocols in Protein Science  2009 Chapter 6:6.10.1-6.10.14  DOI:10.1002/0471140864.ps0610s55  PMID:19235139
    • Rader, C. Generation and selection of rabbit antibody libraries by phage display Methods in Molecular Biology  2009 525:101-128  DOI:10.1007/978-1-59745-554-1_5  PMID:19252834
    • Rader, C. Overview on concepts and applications of Fab antibody fragments Current Protocols in Protein Science  2009 Chapter 6:6.9.1-6.9.14  DOI:10.1002/0471140864.ps0609s55  PMID:19235140
    • Kwong, K. Y., Baskar, S., Zhang, H., Mackall, C. L., Rader, C. Generation, affinity maturation, and characterization of a human anti-human NKG2D monoclonal antibody with dual antagonistic and agonistic activity Journal of Molecular Biology  2008 384:1143-1156  DOI:10.1016/j.jmb.2008.09.008  PMID:18809410  PMCID:PMC2659651
    • Thomas, J. D., Hofer, T., Rader, C., Burke, T. R. Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates Bioorganic & Medicinal Chemistry Letters  2008 18:5785-5788  DOI:10.1016/j.bmcl.2008.09.078  PMID:18922692  PMCID:PMC3461582
    • Hofer, T., Thomas, J. D., Burke, T. R., Rader, C. An engineered selenocysteine defines a unique class of antibody derivatives Proceedings of the National Academy of Sciences of the United States of America  2008 105:12451-12456  DOI:10.1073/pnas.0800800105  PMID:18719095  PMCID:PMC2518826
    • Baskar, S., Kwong, K., Hofer, T., Levy, J. M., Kennedy, M. G., Lee, E., Staudt, L. M., Wilson, W. H., Wiestner, A., Rader, C. Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia Clinical Cancer Research  2008 14:396-404  DOI:10.1158/1078-0432.ccr-07-1823  PMID:18223214
    • Giger, R. J., Venkatesh, K., Chivatakarn, O., Raiker, S. J., Robak, L., Hofer, T., Lee, H. J., Rader, C. Mechanisms of CNS myelin inhibition: evidence for distinct and neuronal cell type specific receptor systems Restorative Neurology and Neuroscience  2008 26:97-115  PMID:18820405
    • Abraham, S., Guo, F., Li, L. S., Rader, C., Liu, C., Barbas, C. F., 3rd, Lerner, R. A., Sinha, S. C. Synthesis of the next-generation therapeutic antibodies that combine cell targeting and antibody-catalyzed prodrug activation Proceedings of the National Academy of Sciences of the United States of America  2007 104:5584-5589  DOI:10.1073/pnas.0700223104  PMID:17372220  PMCID:PMC1838444
    • Hofer, T., Tangkeangsirisin, W., Kennedy, M. G., Mage, R. G., Raiker, S. J., Venkatesh, K., Lee, H., Giger, R. J., Rader, C. Chimeric rabbit/human Fab and IgG specific for members of the Nogo-66 receptor family selected for species cross-reactivity with an improved phage display vector Journal of Immunological Methods  2007 318:75-87  DOI:10.1016/j.jim.2006.10.007  PMID:17140598  PMCID:PMC1930160
    • Rader, C., Barbas III, C. F. Synthetic antibodies prey on B cells Blood  2006 108:2889-2890  DOI:10.1182/blood-2006-08-041327
    • Popkov, M., Rader, C., Gonzalez, B., Sinha, S. C., Barbas, C. F. Small molecule drug activity in melanoma models may be dramatically enhanced with an antibody effector International Journal of Cancer  2006 119:1194-1207  DOI:10.1002/ijc.21924  PMID:16570283
    • Jendreyko, N., Rader, C., Barbas III, C. F., Gaedicke, G. Simultaneous, phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody enhances antiangiogenic effects in vivo Klinische Padiatrie  2006 218:143-151  DOI:10.1055/s-2006-933415  PMID:16688670
    • Nathan, S., Rader, C., Barbas, C. F. Neutralization of Burkholderia pseudomallei protease by Fabs generated through phage display Bioscience Biotechnology and Biochemistry  2005 69:2302-2311  DOI:10.1271/bbb.69.2302  PMID:16377887
    • Popkov, M., Jendreyko, N., McGavern, D. B., Rader, C., Barbas, C. F. Targeting tumor angiogenesis with adenovirus-delivered anti-Tie-2 intrabody Cancer Research  2005 65:972-981  PMID:15705898
    • Venkatesh, K., Chivatakarn, O., Lee, H., Joshi, P. S., Kantor, D. B., Newman, B. A., Mage, R., Rader, C., Giger, R. J. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein Journal of Neuroscience  2005 25:808-822  DOI:10.1523/jneurosci.4464-04.2005  PMID:15673660
    • Jendreyko, N., Popkov, M., Rader, C., Barbas, C. F. Phenotypic knockout of VEGF-R2 and Tie-2 with an intradiabody reduces tumor growth and angiogenesis in vivo Proceedings of the National Academy of Sciences of the United States of America  2005 102:8293-8298  DOI:10.1073/pnas.0503168102  PMID:15928093  PMCID:PMC1149442
    • Li, L. S., Rader, C., Matsushita, M., Das, S., Barbas, C. F., Lerner, R. A., Sinha, S. C. Chemical adaptor immunotherapy: design, synthesis, and evaluation of novel integrin-targeting devices Journal of Medicinal Chemistry  2004 47:5630-5640  DOI:10.1021/jm049666k  PMID:15509162
    • Sinha, S. C., Li, L. S., Watanabe, S., Kaltgrad, E., Tanaka, F., Rader, C., Lerner, R. A., Barbas, C. F. Aldolase antibody activation of prodrugs of potent aldehyde-containing cytotoxics for selective chemotherapy Chemistry-a European Journal  2004 10:5467-5472  DOI:10.1002/chem.200400419  PMID:15378729
    • Popkov, M., Rader, C., Barbas, C. F. Isolation of human prostate cancer cell reactive antibodies using phage display technology Journal of Immunological Methods  2004 291:137-151  DOI:10.1016/j.jim.2004.05.004  PMID:15345312
    • Popkov, M., Jendreyko, N., Gonzalez-Sapienza, G., Mage, R. G., Rader, C., Barbas, C. F. Human/mouse cross-reactive anti-VEGF receptor 2 recombinant antibodies selected from an immune b9 allotype rabbit antibody library Journal of Immunological Methods  2004 288:149-164  DOI:10.1016/j.jim.2004.03.005  PMID:15183093
    • Gopin, A., Rader, C., Shabat, D. New chemical adaptor unit designed to release a drug from a tumor targeting device by enzymatic triggering Bioorganic & Medicinal Chemistry  2004 12:1853-1858  DOI:10.1016/j.bmc.2004.01.41  PMID:15051054
    • Sinha, S. C., Li, L. S., Miller, G. P., Dutta, S., Rader, C., Lerner, R. A. Prodrugs of dynemicin analogs for selective chemotherapy mediated by an aldolase catalytic Ab Proceedings of the National Academy of Sciences of the United States of America  2004 101:3095-3099  DOI:10.1073/pnas.0307319101  PMID:14981258  PMCID:PMC365749
    • Chung, J. H., Rader, C., Popkov, M., Hur, Y. M., Kim, H. K., Lee, Y. J., Barbas, C. F. Integrin α(IIb)β(3)-specific synthetic human monoclonal antibodies and HCDR3 peptides that potently inhibit platelet aggregation FASEB Journal  2004 18:361-363  DOI:10.1096/fj.03-0586fje  PMID:14688205
    • Jendreyko, N., Popkov, M., Beerli, R. R., Chung, J. H., McGavern, D. B., Rader, C., Barbas, C. F. Intradiabodies, bispecific, tetravalent antibodies for the simultaneous functional knockout of two cell surface receptors Journal of Biological Chemistry  2003 278:47812-47819  DOI:10.1074/jbc.M307002200  PMID:12947084
    • Rader, C., Turner, J. M., Heine, A., Shabat, D., Sinha, S. C., Wilson, I. A., Lerner, R. A., Barbas, C. F. A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy Journal of Molecular Biology  2003 332:889-899  DOI:10.1016/s0022-2836(03)00992-6  PMID:12972259
    • Rader, C., Sinha, S. C., Popkov, M., Lerner, R. A., Barbas, C. F. Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst Proceedings of the National Academy of Sciences of the United States of America  2003 100:5396-5400  DOI:10.1073/pnas.0931308100  PMID:12702756  PMCID:PMC154356
    • Popkov, M., Mage, R. G., Alexander, C. B., Thundivalappil, S., Barbas, C. F., Rader, C. Rabbit immune repertoires as sources for therapeutic monoclonal antibodies: the impact of kappa allotype-correlated variation in cysteine content on antibody libraries selected by phage display Journal of Molecular Biology  2003 325:325-335  DOI:10.1016/s0022-2836(02)01232-9  PMID:12488098
    • Rader, C., Popkov, M., Neves, J. A., Barbas, C. F. Integrin α(v)β(3) targeted therapy for Kaposi's sarcoma with an in vitro evolved antibody FASEB Journal  2002 16:2000-2002  DOI:10.1096/fj.02-0281fje  PMID:12397091
    • Kunz, B., Lierheimer, R., Rader, C., Spirig, M., Ziegler, U., Sonderegger, P. Axonin-1/TAG-1 mediates cell-cell adhesion by a cis-assisted trans-interaction Journal of Biological Chemistry  2002 277:4551-4557  DOI:10.1074/jbc.M109779200  PMID:11733523
    • Plagge, A., Sendtner-Voelderndorff, L., Sirim, P., Freigang, J., Rader, C., Sonderegger, P., Brummendorf, T. The contactin-related protein FAR-2 defines Purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum Molecular and Cellular Neuroscience  2001 18:91-107  DOI:10.1006/mcne.2001.1006  PMID:11461156
    • Shabat, D., Lode, H. N., Pertl, U., Reisfeld, R. A., Rader, C., Lerner, R. A., Barbas, C. F. In vivo activity in a catalytic antibody-prodrug system: antibody catalyzed etoposide prodrug activation for selective chemotherapy Proceedings of the National Academy of Sciences of the United States of America  2001 98:7528-7533  DOI:10.1073/pnas.131187998  PMID:11404472  PMCID:PMC34702
    • Sonderegger, P., Kunz, S., Rader, C., Suter, D. M., Stoeckli, E. T. Analysis of cell-cell contact mediated by Ig superfamily cell adhesion molecules Current Protocols in Cell Biology  2001 Chapter 9:9.5.1–9.5.52  DOI:10.1002/0471143030.cb0905s11  PMID:18228394
    • Rader, C. Antibody libraries in drug and target discovery Drug Discovery Today  2001 6:36-43  DOI:10.1016/s1359-6446(00)01595-6  PMID:11165171
    • Steinberger, P., Sutton, J. K., Rader, C., Elia, M., Barbas, C. F. Generation and characterization of a recombinant human CCR5-specific antibody. A phage display approach for rabbit antibody humanization Journal of Biological Chemistry  2000 275:36073-36078  DOI:10.1074/jbc.M002765200  PMID:10969070
    • Andris-Widhopf, J., Rader, C., Steinberger, P., Fuller, R., Barbas, C. F. Methods for the generation of chicken monoclonal antibody fragments by phage display Journal of Immunological Methods  2000 242:159-181  DOI:10.1016/s0022-1759(00)00221-0  PMID:10986398
    • Rader, C., List, B. Catalytic antibodies as magic bullets Chemistry-a European Journal  2000 6:2091-2095  DOI:10.1002/1521-3765(20000616)6:12<2091::aid-chem2091>3.3.co;2-j  PMID:10926212
    • Fitzli, D., Stoeckli, E. T., Kunz, S., Siribour, K., Rader, C., Kunz, B., Kozlov, S. V., Buchstaller, A., Lane, R. P., Suter, D. M., Dreyer, W. J., Sonderegger, P. A direct interaction of axonin-1 with NgCAM-related cell adhesion molecule (NrCAM) results in guidance, but not growth of commissural axons Journal of Cell Biology  2000 149:951-968  DOI:10.1083/jcb.149.4.951  PMID:10811834
    • Rader, C., Ritter, G., Nathan, S., Elia, M., Gout, I., Jungbluth, A. A., Cohen, L. S., Welt, S., Old, L. J., Barbas, C. F. The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies Journal of Biological Chemistry  2000 275:13668-13676  DOI:10.1074/jbc.275.18.13668  PMID:10788485
    • Karlstrom, A., Zhong, G. F., Rader, C., Larsen, N. A., Heine, A., Fuller, R., List, B., Tanaka, F., Wilson, I. A., Barbas, C. F., Lerner, R. A. Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task Proceedings of the National Academy of Sciences of the United States of America  2000 97:3878-3883  DOI:10.1073/pnas.97.8.3878  PMID:10760259
    • Barbas, C. F., Rader, C., Segal, D. J., List, B., Turner, J. M. From catalytic asymmetric synthesis to the transcriptional regulation of genes: in vivo and in vitro evolution of proteins Advances in Protein Chemistry  2000 55:317-366  DOI:10.1016/S0065-3233(01)55008-1  PMID:11050938
    • Shabat, D., Rader, C., List, B., Lerner, R. A., Barbas, C. F. Multiple event activation of a generic prodrug trigger by antibody catalysis Proceedings of the National Academy of Sciences of the United States of America  1999 96:6925-6930  DOI:10.1073/pnas.96.12.6925  PMID:10359815
    • Kunz, S., Spirig, M., Ginsburg, C., Buchstaller, A., Berger, P., Lanz, R., Rader, C., Vogt, L., Kunz, B., Sonderegger, P. Neurite fasciculation mediated by complexes of axonin-1 and Ng cell adhesion molecule Journal of Cell Biology  1998 143:1673-1690  DOI:10.1083/jcb.143.6.1673  PMID:9852159
    • Rader, C., Cheresh, D. A., Barbas, C. F. A phage display approach for rapid antibody humanization: designed combinatorial V gene libraries Proceedings of the National Academy of Sciences of the United States of America  1998 95:8910-8915  DOI:10.1073/pnas.95.15.8910  PMID:9671778
    • Sonderegger, P., Kunz, S., Rader, C., Buchstaller, A., Berger, P., Vogt, L., Kozlov, S. V., Ziegler, U., Kunz, B., Fitzli, D., Stoeckli, E. T. Discrete clusters of axonin-1 and NgCAM at neuronal contact sites: facts and speculations on the regulation of axonal fasciculation Progress in Brain Research  1998 117:93-104  PMID:9932403
    • Rader, C., Sonderegger, P. Structural features of neural immunoglobulin superfamily adhesion molecules Cell Adhesion and Communication  1998 6:1-22
    • Rader, C., Barbas, C. F. Phage display of combinatorial antibody libraries Current Opinion in Biotechnology  1997 8:503-508  DOI:10.1016/s0958-1669(97)80075-4  PMID:9265732
    • Buchstaller, A., Kunz, S., Berger, P., Kunz, B., Ziegler, U., Rader, C., Sonderegger, P. Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion Journal of Cell Biology  1996 135:1593-1607  DOI:10.1083/jcb.135.6.1593  PMID:8978825
    • Rader, C., Kunz, B., Lierheimer, R., Giger, R. J., Berger, P., Tittmann, P., Gross, H., Sonderegger, P. Implications for the domain arrangement of axonin-1 derived from the mapping of its NgCAM binding site EMBO Journal  1996 15:2056-2068  PMID:8641271  PMCID:PMC450127
    • Giger, R. J., Vogt, L., Zuellig, R. A., Rader, C., Henehanbeatty, A., Wolfer, D. P., Sonderegger, P. The gene of chicken axonin-1. Complete structure and analysis of the promoter European Journal of Biochemistry  1995 227:617-628  DOI:10.1111/j.1432-1033.1995.tb20181.x  PMID:7867620
    • Rader, C., Stoeckli, E. T., Ziegler, U., Osterwalder, T., Kunz, B., Sonderegger, P. Cell-cell adhesion by homophilic interaction of the neuronal recognition molecule axonin-1 European Journal of Biochemistry  1993 215:133-141  DOI:10.1111/j.1432-1033.1993.tb18015.x  PMID:8344273
    • Hasler, T. H., Rader, C., Stoeckli, E. T., Zuellig, R. A., Sonderegger, P. cDNA cloning, structural features, and eucaryotic expression of human TAG-1/axonin-1 European Journal of Biochemistry  1993 211:329-339  DOI:10.1111/j.1432-1033.1993.tb19902.x  PMID:8425542
    • Zuellig, R. A., Rader, C., Schroeder, A., Kalousek, M. B., Von Bohlen und Halbach, F., Osterwalder, T., Inan, C., Stoeckli, E. T., Halbach, F., Affolter, H. U., Fritz, A., Hafen, E., et al. The axonally secreted cell adhesion molecule, axonin-1. Primary structure, immunoglobulin-like and fibronectin-type-III-like domains and glycosyl-phosphatidylinositol anchorage European Journal of Biochemistry  1992 204:453-463  DOI:10.1111/j.1432-1033.1992.tb16655.x  PMID:1311675
  • chapter

    • Nanna, A. R., Roush, W. R., Rader, C. Chemical assembly of antibody-drug conjugates Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins. 1-28. 2017
    • Bishop, M. R., Shaffer, B., Rader, C. CD20 Encyclopedia of cancer therapeutic targets. 2012
    • Rader, C. Monoclonal antibody therapy for cancer Experimental and applied immunotherapy. 59-83. 2011  DOI:10.1007/978-1-60761-980-2_3
    • Rader, C., Bishop, M. R. Monoclonal antibodies in cancer therapy General principles of tumor immunotherapy : basic and clinical applications of tumor immunology. 453-484. 2007  DOI:10.1007/978-1-4020-6087-8_20
    • Steinberger, P., Rader, C., Barbas III, C. F. Analysis of selected antibodies Phage display : a laboratory manual. 11.1-11.24. 2001
    • Rader, C., Barbas III, C. F. Antibody engineering Phage display : a laboratory manual. 13.1-13.15. 2001
    • Andris-Widhopf, J., Steinberger, P., Fuller, R., Rader, C., Barbas III, C. F. Generation of antibody libraries: PCR amplification and assembly of light- and heavy-chain coding sequences Phage display : a laboratory manual. 9.1-9.113. 2001
    • Andris-Widhopf, J., Rader, C., Barbas III, C. F. Generation of antibody libraries: immunization, RNA preparation, and cDNA synthesis Phage display : a laboratory manual. 8.1-8.18. 2001
    • Rader, C., Steinberger, P., Barbas III, C. F. Selection from antibody libraries Phage display : a laboratory manual. 10.1-10.20. 2001
  • patent

    • Barbas III, C. F., Shabat, D., Rader, C., List, B., Lerner, R. A., inventors; Scripps Research, assignee. Prodrug activation using catalytic antibodies World patent WO2000071556A1 (2000).

featured in

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  • Scripps Florida Mentorship Award Honors Laura Niedernhofer and Christoph Rader  Newsletter
  • Scripps Florida Scientists Awarded $1.4 Million to Develop New Therapeutic Approaches to Chronic Leukemia  News Release
  • Scripps Research Institute Appoints NIH Senior Scientist to Cancer Biology Department  News Release
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Research

research overview

  • Since 1997, 13 monoclonal antibodies (mAbs) have been approved by the FDA for cancer therapy and many more are in advanced clinical trials. To contribute to the next generation of mAbs for cancer therapy, we pursue both antibody target and drug discovery strategies.  Our target discovery efforts aim at identifying new antigens suitable for mAb therapy of cancer.  Our drug discovery efforts have the objective to develop and utilize antibody display, antibody engineering, and antibody conjugation methods for improving the potency of mAbs.  We have a particular interest in antibody technologies at the interface of chemistry and biology, including the generation of molecularly defined antibody-drug conjugates and chemically programmed bispecific antibodies.
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Teaching

advisees

  • graduate advising relationship

    • Adhikari, Ajeeth, Ph.D.  candidate, 2016 -
    • Cyr, Matthew Gerard, Ph.D.  candidate, 2018 -
    • Goydel, Rebecca S., Ph.D.  candidate, 2017 -
    • Wilson, Henry, Ph.D.  candidate, 2014 - 2019
    • Nanna, Alex, Ph.D.  candidate, 2014 - 2018
  • postdoc or fellow advising relationship

    • Nanna, Alex, Ph.D.  candidate, 2018 - 2019
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Background

education and training

  • Ph.D. in Biochemistry and Molecular Biology, University of Zurich 1995
  • M.S. in Biochemistry and Molecular Biology, University of Zurich 1991
  • B.S. in Biochemistry and Chemistry, University of Bayreuth 1988
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Contact

full name

  • Christoph Rader

geographic location

  • Scripps Florida 

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