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Puthanveettil, Sathyanarayanan
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Puthanveettil, Sathyanarayanan

Faculty Member
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Positions

  • 2015 - Associate Professor, Neuroscience , Scripps Research
  • 2010 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2010 - 2015 Assistant Professor, Neuroscience , Scripps Research
  • 2005 - 2010 Associate Research Scientist, Columbia University
  • 2002 - 2004 Postdoctoral Fellow with Dr. Eric Kandel, Columbia University
Dr. Puthanveettil uses an integrated approach that combines high throughput biology, electrophysiology and behavior to investigate the molecular and cellular basis of long-term memory storage and cognitive disorders.

Contact

  • sputhanv@scripps.edu

Websites

  • Sathyanarayanan Puthanveettil, Ph.D.
  • Laboratory Website
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  • Research
  • Teaching
  • Background
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Publications

recent publications
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  • academic article

    • Swarnkar, S., Avchalumov, Y., Espadas, I., Grinman, E., Liu, X. A., Raveendra, B. L., Zucca, A., Mediouni, S., Sadhu, A., Valente, S., Page, D., Miller, K., et al. Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation Cell Reports  2021 36  DOI:10.1016/j.celrep.2021.109369  PMID:34260917  PMCID:PMC8319835
    • Puthanveettil, S. V. The emerging RNA-centric world of neurobiology RNA Biology  2021 18:933-935  DOI:10.1080/15476286.2021.1930367  PMID:34142924  PMCID:PMC8216184
    • Grinman, E., Nakahata, Y., Avchalumov, Y., Espadas, I., Swarnkar, S., Yasuda, R., Puthanveettil, S. V. Activity-regulated synaptic targeting of lncRNA ADEPTR mediates structural plasticity by localizing Sptn1 and AnkB in dendrites Science Advances  2021 7  DOI:10.1126/sciadv.abf0605  PMID:33863727  PMCID:PMC8051873
    • Joseph, N. F., Swarnkar, S., Puthanveettil, S. V. Double Duty: Mitotic Kinesins and Their Post-Mitotic Functions in Neurons Cells  2021 10  DOI:10.3390/cells10010136  PMID:33445569  PMCID:PMC7827351
    • Joseph, N. F., Zucca, A., Wingfield, J. L., Espadas, I., Page, D., Puthanveettil, S. V. Molecular motor KIF3B in the prelimbic cortex constrains the consolidation of contextual fear memory Molecular Brain  2021 14  DOI:10.1186/s13041-021-00873-9  PMID:34749771  PMCID:PMC8573985
    • Joseph, N. F., Grinman, E., Swarnkar, S., Puthanveettil, S. V. Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons Frontiers in Cellular Neuroscience  2020 14  DOI:10.3389/fncel.2020.521199  PMID:33192305  PMCID:PMC7604319
    • Varkuti, B. H., Kepiro, M., Liu, Z., Vick, K., Avchalumov, Y., Pacifico, R., MacMullen, C. M., Kamenecka, T. M., Puthanveettil, S. V., Davis, R. L. Neuron-based high-content assay and screen for CNS active mitotherapeutics Science Advances  2020 6  DOI:10.1126/sciadv.aaw8702  PMID:31934620  PMCID:PMC6949038
    • Grinman, E., Espadas, I., Puthanveettil, S. V. Emerging roles for long noncoding RNAs in learning, memory and associated disorders Neurobiology of Learning and Memory  2019 163  DOI:10.1016/j.nlm.2019.107034  PMID:31176693
    • Badal, K. K., Akhmedov, K., Lamoureux, P., Liu, X. A., Reich, A., Fallahi-Sichani, M., Swarnkar, S., Miller, K. E., Puthanveettil, S. V. Synapse formation activates a transcriptional program for persistent enhancement in the bi-directional transport of mitochondria Cell Reports  2019 26:507-517  DOI:10.1016/j.celrep.2018.12.073  PMID:30650345
    • Swarnkar, S., Avchalumov, Y., Raveendra, B. L., Grinman, E., Puthanveettil, S. V. Kinesin family of proteins Kif11 and Kif21B Act as inhibitory constraints of excitatory synaptic transmission through distinct mechanisms Scientific Reports  2018 8  DOI:10.1038/s41598-018-35634-7  PMID:30479371  PMCID:PMC6258692
    • Raveendra, B. L., Swarnkar, S., Avchalumov, Y., Liu, X. A., Grinman, E., Badal, K., Reich, A., Pascal, B. D., Puthanveettil, S. V. Long noncoding RNA GM12371 acts as a transcriptional regulator of synapse function Proceedings of the National Academy of Sciences of the United States of America  2018 115:E10197-E10205  DOI:10.1073/pnas.1722587115  PMID:30297415  PMCID:PMC6205475
    • Miller, K. E., Liu, X. A., Puthanveettil, S. V. Automated measurement of fast mitochondrial transport in neurons Frontiers in Cellular Neuroscience  2015 9:435  DOI:10.3389/fncel.2015.00435  PMID:26578890  PMCID:PMC4630299
    • Rumbaugh, G., Sillivan, S. E., Ozkan, E. D., Rojas, C. S., Hubbs, C. R., Kilgore, M., Kudugunti, S., Puthanveettil, S. V., Sweatt, J. D., Rusche, J., Miller, C. A. Pharmacological selectivity within class I histone deacetylases predicts effects on synaptic function and memory rescue Neuropsychopharmacology  2015 40:2307-2316  DOI:10.1038/npp.2015.93  PMID:25837283  PMCID:PMC4538358
    • Kadakkuzha, B. M., Liu, X. A., McCrate, J., Shankar, G., Rizzo, V., Afinogenova, A., Young, B., Fallahi, M., Carvalloza, A. C., Raveendra, B., Puthanveettil, S. V. Transcriptome analyses of adult mouse brain reveal enrichment of IncRNAs in specific brain regions and neuronal populations Frontiers in Cellular Neuroscience  2015 9:63  DOI:10.3389/fncel.2015.00063  PMID:25798087  PMCID:PMC4351618
    • Rizzo, V., Richman, J., Puthanveettil, S. V. Dissecting mechanisms of brain aging by studying the intrinsic excitability of neurons Frontiers in Aging Neuroscience  2015 6  DOI:10.3389/fnagi.2014.00337  PMID:25610394  PMCID:PMC4285138
    • Liu, X. A., Kadakkuzha, B., Pascal, B., Steckler, C., Akhmedov, K., Yan, L., Chalmers, M., Puthanveettil, S. V. New approach to capture and characterize synaptic proteome Proceedings of the National Academy of Sciences of the United States of America  2014 111:16154-16159  DOI:10.1073/pnas.1401483111  PMID:25352669  PMCID:PMC4234550
    • Kadakkuzha, B. M., Spicer, T. P., Chase, P., Richman, J. B., Hodder, P., Puthanveettil, S. V. High-throughput screening for small molecule modulators of motor protein Kinesin Assay and Drug Development Technologies  2014 12:470-480  DOI:10.1089/adt.2014.579  PMID:25383721
    • Choi, Y. B., Kadakkuzha, B. M., Liu, X. A., Akhmedov, K., Kandel, E. R., Puthanveettil, S. V. Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in Aplysia PLoS One  2014 9:e103004  DOI:10.1371/journal.pone.0103004  PMID:25054562  PMCID:PMC4108396
    • Akhmedov, K., Kadakkuzha, B. M., Puthanveettil, S. V. Aplysia Ganglia preparation for electrophysiological and molecular analyses of single neurons Journal of Visualized Experiments : JoVE  2014 e51075  DOI:10.3791/51075  PMID:24457225  PMCID:PMC4089395
    • Akhmedov, K., Rizzo, V., Kadakkuzha, B. M., Carter, C. J., Magoski, N. S., Capo, T. R., Puthanveettil, S. V. Decreased response to acetylcholine during aging of aplysia neuron R15 PLoS One  2013 8:e84793  DOI:10.1371/journal.pone.0084793  PMID:24386417  PMCID:PMC3874043
    • Kadakkuzha, B. M., Akhmedov, K., Capo, T. R., Carvalloza, A. C., Fallahi, M., Puthanveettil, S. V. Age-associated bidirectional modulation of gene expression in single identified R15 neuron of Aplysia BMC Genomics  2013 14:880  DOI:10.1186/1471-2164-14-880  PMID:24330282  PMCID:PMC3909179
    • Puthanveettil, S. V. RNA transport and long-term memory storage RNA Biology  2013 10:1765-1770  DOI:10.4161/rna.27391  PMID:24356491  PMCID:PMC3917979
    • Puthanveettil, S. V., Antonov, I., Kalachikov, S., Rajasethupathy, P., Choi, Y. B., Kohn, A. B., Citarella, M., Yu, F. H., Karl, K. A., Kinet, M., Morozova, I., Russo, J. J., et al. A strategy to capture and characterize the synaptic transcriptome Proceedings of the National Academy of Sciences of the United States of America  2013 110:7464-7469  DOI:10.1073/pnas.1304422110  PMID:23589870  PMCID:PMC3645558
    • Kadakkuzha, B. M., Puthanveettil, S. V. Genomics and proteomics in solving brain complexity Molecular Biosystems  2013 9:1807-1821  DOI:10.1039/c3mb25391k  PMID:23615871
    • Liu, X. A., Rizzo, V., Puthanveettil, S. V. Pathologies of axonal transport in neurodegenerative diseases Translational Neuroscience  2012 3:355-372  DOI:10.2478/s13380-012-0044-7  PMID:23750323  PMCID:PMC3674637
    • Choi, Y. B., Li, H. L., Kassabov, S. R., Jin, I., Puthanveettil, S. V., Karl, K. A., Lu, Y., Kim, J. H., Bailey, C. H., Kandel, E. R. Neurexin-neuroligin transsynaptic interaction mediates learning-related synaptic remodeling and long-term facilitation in aplysia Neuron  2011 70:468-481  DOI:10.1016/j.neuron.2011.03.020  PMID:21555073  PMCID:PMC3136118
    • Rajasethupathy, P., Fiumara, F., Sheridan, R., Betel, D., Puthanveettil, S. V., Russo, J. J., Sander, C., Tuschl, T., Kandel, E. Characterization of small RNAs in aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB Neuron  2009 63:803-817  DOI:10.1016/j.neuron.2009.05.029  PMID:19778509  PMCID:PMC2875683
    • Puthanveettil, S. V., Monje, F. J., Miniaci, M. C., Choi, Y. B., Karl, K. A., Khandros, E., Gawinowicz, M. A., Sheetz, M. P., Kandel, E. R. A new component in synaptic plasticity: Upregulation of kinesin in the neurons of the gill-withdrawal reflex Cell  2008 135:960-973  DOI:10.1016/j.cell.2008.11.003  PMID:19041756  PMCID:PMC2635114
    • Miniaci, M. C., Kim, J. H., Puthanveettil, S. V., Si, K., Zhu, H. X., Kandel, E. R., Bailey, C. H. Sustained CPEB-dependent local protein synthesis is required to stabilize synaptic growth for persistence of long-term facilitation in Aplysia Neuron  2008 59:1024-1036  DOI:10.1016/j.neuron.2008.07.036  PMID:18817739  PMCID:PMC3442368
    • Touzani, K., Puthanveettil, S. V., Kandel, E. R. Consolidation of learning strategies during spatial working memory task requires protein synthesis in the prefrontal cortex Proceedings of the National Academy of Sciences of the United States of America  2007 104:5632-5637  DOI:10.1073/pnas.0611554104  PMID:17369358  PMCID:PMC1838463
    • Moroz, L. L., Edwards, J. R., Puthanveettil, S. V., Kohn, A. B., Hla, T., Heyland, A., Knudsen, L., Sahni, A., Yu, F. H., Liu, L., Jezzini, S., Lovell, P., et al. Neuronal transcriptome of aplysia: Neuronal compartments and circuitry Cell  2006 127:1453-1467  DOI:10.1016/j.cell.2006.09.052  PMID:17190607  PMCID:PMC4024467
    • Marti, A. A., Li, X. X., Jockusch, S., Li, Z. M., Raveendra, B., Kalachikov, S., Russo, J. J., Morozova, I., Puthanveettil, S. V., Ju, J. Y., Turro, N. J. Pyrene binary probes for unambiguous detection of mrna using time-resolved fluorescence spectroscopy Nucleic Acids Research  2006 34:3161-3168  DOI:10.1093/nar/gkl406  PMID:16769776  PMCID:PMC1477857

featured in

  • Sathyanarayanan Puthanveettil Appointed to Scripps Research Faculty  Newsletter
  • Scripps Florida Scientists Offer New Insight into Neuron Changes Brought About by Aging  News Release
  • Scripps Research Scientist Wins Pair of Grants to Study Critical Component of Memory  News Release
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Research

research overview

  • Molecular Logic For The Storage and Maintenance Of Long-Term Memory

    The long-term goal of my laboratory is to understand the molecular and cellular basis of memory storage and cognitive disorders. At the cellular level there are two hallmarks of long-term memory storage: experience-dependent activation of gene expression in the nucleus, and local activation of translation at specific synapses.

    Previously I have demonstrated in Eric Kandel’s laboratory that activation of fast axonal transport in pre- and post- synaptic neurons during learning is another critical component of long-term memory storage. Activation of molecular transport to synapses is a rate limiting step and coordinates nuclear and synaptic processes during memory storage. The transported cargos include organelles, proteins, mRNAs, and noncoding RNAs.

    In an effort to learn what gene products are transported in specific neurons in response to activity, how they are transported, how they are stored for later use, and eventually when and how they are utilized at specific synapses during learning and memory storage, my laboratory uses an integrated approach that combines several high throughput techniques such as genomics and proteomics with electrophysiology, biochemistry, and imaging. A comprehensive understanding of transported cargos will help us in elucidating signaling pathways at the synapse and mechanisms underlying synaptic dysfunction. Animal models such as Aplysia and mice are used to tackle these questions at the cellular and systems levels. In addition, we explore these questions using mouse models for cognitive disorders such as Alzheimer’s and Huntington’s disease.

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Teaching

advisees

  • graduate advising relationship

    • Grinman, Eddie, Ph.D.  candidate, 2016 -
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Background

education and training

  • B.S. in Biology, Kerala Agricultural University
  • M.S. in Biotechnology, Tamil Nadu Agricultural University
  • Ph.D. in Biology, Washington State University
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Contact

full name

  • Sathyanarayanan Puthanveettil

geographic location

  • Scripps Florida 

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