recent publications
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academic article
- Grandjean, J. M. D., Madhavan, A., Cech, L., Seguinot, B. O., Paxman, R. J., Smith, E., Scampavia, L., Powers, E. T., Cooley, C. B., Plate, L., Spicer, T. P., Kelly, J. W., et al. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming Nature Chemical Biology 2020 DOI:10.1038/s41589-020-0584-z PMID:32690944
- Nelson, L. T., Paxman, R. J., Xu, J., Webb, B., Powers, E. T., Kelly, J. W. Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma Amyloid-Journal of Protein Folding Disorders 2020 DOI:10.1080/13506129.2020.1808783 PMID:32811187
- Ibrahim, L., Mesgarzadeh, J., Xu, I., Powers, E. T., Wiseman, R. L., Bollong, M. J. Defining the Functional Targets of Cap'n'collar Transcription Factors NRF1, NRF2, and NRF3 Antioxidants 2020 9 DOI:10.3390/antiox9101025 PMID:33096892 PMCID:PMC7588902
- Pobre, K. F. R., Powers, D. L., Ghosh, K., Gierasch, L. M., Powers, E. T. Kinetic versus thermodynamic control of mutational effects on protein homeostasis: A perspective from computational modeling and experiment Protein Science 2019 28:1324-1339 DOI:10.1002/pro.3639 PMID:31074892 PMCID:PMC6566562
- Monteiro, C., Mesgazardeh, J. S., Anselmo, J., Fernandes, J., Novais, M., Rodrigues, C., Brighty, G. J., Powers, D. L., Powers, E. T., Coelho, T., Kelly, J. W. Predictive model of response to tafamidis in hereditary ATTR polyneuropathy JCI Insight 2019 4 DOI:10.1172/jci.insight.126526 PMID:31217346
- Grandjean, J. M. D., Plate, L., Morimoto, R. I., Bollong, M. J., Powers, E. T., Wiseman, R. L. Deconvoluting stress-responsive proteostasis signaling pathways for pharmacologic activation using targeted RNA sequencing ACS Chemical Biology 2019 14:784-795 DOI:10.1021/acschembio.9b00134 PMID:30821953 PMCID:PMC6474822
- Lampkin, B. J., Monteiro, C., Powers, E. T., Bouc, P. M., Kelly, J. W., VanVeller, B. A designed protein binding-pocket to control excited-state intramolecular proton transfer fluorescence Organic & Biomolecular Chemistry 2019 17:1076-1080 DOI:10.1039/c8ob02673d PMID:30534794
- Paxman, R., Plate, L., Blackwood, E. A., Glembotski, C., Powers, E. T., Wiseman, R. L., Kelly, J. W. Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins Elife 2018 7 DOI:10.7554/eLife.37168 PMID:30084354 PMCID:PMC6080950
- Kroeger, H., Grimsey, N., Paxman, R., Chiang, W. C., Plate, L., Jones, Y., Shaw, P. X., Trejo, J., Tsang, S. H., Powers, E., Kelly, J. W., Wiseman, R. L., et al. The unfolded protein response regulator ATF6 promotes mesodermal differentiation Science Signaling 2018 11 DOI:10.1126/scisignal.aan5785 PMID:29440509
- Morgan, G. J., Burkhardt, D. H., Kelly, J. W., Powers, E. T. Translation efficiency is maintained at elevated temperature in Escherichia coli Journal of Biological Chemistry 2018 293:777-793 DOI:10.1074/jbc.RA117.000284 PMID:29183994 PMCID:PMC5777253
- Mortenson, D. E., Brighty, G. J., Plate, L., Bare, G., Chen, W., Li, S. H., Wang, H., Cravatt, B. F., Forli, S., Powers, E. T., Sharpless, K. B., Wilson, I. A., et al. "Inverse drug discovery" strategy to identify proteins that are targeted by latent electrophiles as exemplified by aryl fluorosulfates Journal of the American Chemical Society 2018 140:200-210 DOI:10.1021/jacs.7b08366
- Schonhoft, J. D., Monteiro, C., Plate, L., Eisele, Y. S., Kelly, J. M., Boland, D., Parker, C. G., Cravatt, B. F., Teruya, S., Helmke, S., Maurer, M., Berk, J., et al. Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients Science Translational Medicine 2017 9 DOI:10.1126/scitranslmed.aam7621 PMID:28904227
- Connelly, S., Mortenson, D. E., Choi, S., Wilson, I. A., Powers, E. T., Kelly, J. W., Johnson, S. M. Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors Bioorganic & Medicinal Chemistry Letters 2017 27:3441-3449 DOI:10.1016/j.bmcl.2017.05.080 PMID:28625364
- Chen, K. C., Qu, S., Chowdhury, S., Noxon, I. C., Schonhoft, J. D., Plate, L., Powers, E. T., Kelly, J. W., Lander, G. C., Wiseman, R. L. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer EMBO Journal 2017 36:2296-2309 DOI:10.15252/embj.201695616
- Ardejani, M. S., Powers, E. T., Kelly, J. W. Using cooperatively folded peptides to measure interaction energies and conformational propensities Accounts of Chemical Research 2017 50:1875-1882 DOI:10.1021/acs.accounts.7b00195 PMID:28723063 PMCID:PMC5584629
- Hingorani, K. S., Metcalf, M. C., Deming, D. T., Garman, S. C., Powers, E. T., Gierasch, L. M. Ligand-promoted protein folding by biased kinetic partitioning Nature Chemical Biology 2017 13:369-371 PMID:28218913 PMCID:PMC5362304
- Plate, L., Cooley, C. B., Chen, J. J., Paxman, R. J., Gallagher, C. M., Madoux, F., Genereux, J. C., Dobbs, W., Garza, D., Spicer, T. P., Scampavia, L., Brown, S. J., et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Elife 2016 5 DOI:10.7554/eLife.15550 PMID:27435961 PMCID:PMC4954754
- Chen, W., Kong, L., Connelly, S., Liu, Y., Wilson, I. A., Powers, E. T., Kelly, J. W. Stabilizing the C(H)2 domain of an antibody by engineering in an enhanced aromatic sequon ACS Chemical Biology 2016 11:1852-1861 DOI:10.1021/acschembio.5b01035 PMID:27128252 PMCID:PMC4852379
- Hsu, C. H., Park, S., Mortenson, D. E., Foley, B. L., Wang, X., Woods, R. J., Case, D. A., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. The dependence of carbohydrate-aromatic interaction strengths on the structure of the carbohydrate Journal of the American Chemical Society 2016 138:7636-7648 DOI:10.1021/jacs.6b02879 PMID:27249581 PMCID:PMC4924591
- Chen, W., Dong, J., Plate, L., Mortenson, D. E., Brighty, G. J., Li, S., Liu, Y., Galmozzi, A., Lee, P. S., Hulce, J. J., Cravatt, B. F., Saez, E., et al. Arylfluorosulfates inactivate intracellular lipid binding protein(s) through chemoselective SuFEx reaction with a binding site Tyr residue Journal of the American Chemical Society 2016 138:7353-7364 DOI:10.1021/jacs.6b02960 PMID:27191344 PMCID:PMC4909538
- Eisele, Y. S., Monteiro, C., Fearns, C., Encalada, S. E., Wiseman, R. L., Powers, E. T., Kelly, J. W. Targeting protein aggregation for the treatment of degenerative diseases Nature Reviews Drug Discovery 2015 14:759-780 DOI:10.1038/nrd4593 PMID:26338154 PMCID:PMC4628595
- Murray, A. N., Chen, W., Antonopoulos, A., Wiseman, R. L., Dell, A., Haslam, S. M., Powers, D. L., Powers, E. T., Kelly, J. W. Enhanced aromatic sequons increase oligosaccharyltransferase glycosylation efficiency and glycan homogeneity Chemistry & Biology 2015 22:1052-1062 DOI:10.1016/j.chembiol.2015.06.017 PMID:26190824 PMCID:PMC4546532
- Powers, E. T. Translation: An O-GlcNAc stamp of approval Nature Chemical Biology 2015 11:307-308 DOI:10.1038/nchembio.1777 PMID:25774940
- Cho, Y., Zhang, X., Pobre, K. F. R., Liu, Y., Powers, D. L., Kelly, J. W., Gierasch, L. M., Powers, E. T. Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli Cell Reports 2015 11:321-333 DOI:10.1016/j.celrep.2015.03.018 PMID:25843722 PMCID:PMC4401642
- Hebert, D. N., Lamriben, L., Powers, E. T., Kelly, J. W. The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis Nature Chemical Biology 2014 10:902-910 PMID:25325701 PMCID:PMC4232232
- Ryno, L. M., Genereux, J. C., Naito, T., Morimoto, R. I., Powers, E. T., Shoulders, M. D., Wiseman, R. L. Characterizing the altered cellular proteome induced by the stress-independent activation of heat shock factor 1 ACS Chemical Biology 2014 9:1273-1283 DOI:10.1021/cb500062n PMID:24689980 PMCID:PMC4076015
- Baranczak, A., Connelly, S., Liu, Y., Choi, S., Grimster, N. P., Powers, E. T., Wilson, I. A., Kelly, J. W. Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging: what we know and what we need to learn Biopolymers 2014 101:484-495 DOI:10.1002/bip.22407 PMID:24105107 PMCID:PMC4128284
- Rappley, I., Monteiro, C., Novais, M., Baranczak, A., Solis, G., Wiseman, R. L., Helmke, S., Maurer, M. S., Coelho, T., Powers, E. T., Kelly, J. W. Quantification of transthyretin kinetic stability in human plasma using subunit exchange Biochemistry 2014 53:1993-2006 DOI:10.1021/bi500171j PMID:24661308 PMCID:PMC3977577
- Chen, W., Enck, S., Price, J. L., Powers, D. L., Powers, E. T., Wong, C. H., Dyson, H. J., Kelly, J. W. Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins Journal of the American Chemical Society 2013 135:9877-9884 DOI:10.1021/ja4040472 PMID:23742246 PMCID:PMC3715148
- Talantova, M., Sanz-Blasco, S., Zhang, X. F., Xia, P., Akhtar, M. W., Okamoto, S., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., Kang, Y. J., Tu, S., et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss Proceedings of the National Academy of Sciences of the United States of America 2013 110:E2518-E2527 DOI:10.1073/pnas.1306832110 PMID:23776240 PMCID:PMC3704025
- Penchala, S. C., Connelly, S., Wang, Y., Park, M. S., Zhao, L., Baranczak, A., Rappley, I., Vogel, H., Liedtke, M., Witteles, R. M., Powers, E. T., Reixach, N., et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin Proceedings of the National Academy of Sciences of the United States of America 2013 110:9992-9997 DOI:10.1073/pnas.1300761110 PMID:23716704 PMCID:PMC3683741
- Grimster, N. P., Connelly, S., Baranczak, A., Dong, J. J., Krasnova, L. B., Sharpless, K. B., Powers, E. T., Wilson, I. A., Kelly, J. W. Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate Journal of the American Chemical Society 2013 135:5656-5668 DOI:10.1021/ja311729d PMID:23350654 PMCID:PMC3630275
- Powers, E. T., Balch, W. E. Diversity in the origins of proteostasis networks: a driver for protein function in evolution Nature Reviews Molecular Cell Biology 2013 14:237-248 DOI:10.1038/nrm3542 PMID:23463216 PMCID:PMC3718298
- Johnson, S. M., Connelly, S., Fearns, C., Powers, E. T., Kelly, J. W. The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug Journal of Molecular Biology 2012 421:185-203 DOI:10.1016/j.jmb.2011.12.060 PMID:22244854 PMCID:PMC3350832
- Bulawa, C. E., Connelly, S., Devit, M., Wang, L., Weigel, C., Fleming, J. A., Packman, J., Powers, E. T., Wiseman, R. L., Foss, T. R., Wilson, I. A., Kelly, J. W., et al. Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade Proceedings of the National Academy of Sciences of the United States of America 2012 109:9629-9634 DOI:10.1073/pnas.1121005109 PMID:22645360 PMCID:PMC3386102
- Powers, E. T., Powers, D. L., Gierasch, L. M. FoldEco: A model for proteostasis in E. coli Cell Reports 2012 1:265-276 DOI:10.1016/j.celrep.2012.02.011 PMID:22509487 PMCID:PMC3324317
- Price, J. L., Culyba, E. K., Chen, W., Murray, A. N., Hanson, S. R., Wong, C. H., Powers, E. T., Kelly, J. W. N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability Biopolymers 2012 98:195-211 DOI:10.1002/bip.22030 PMID:22782562 PMCID:PMC3539202
- Orwig, S. D., Tan, Y. L., Grimster, N. P., Yu, Z. Q., Powers, E. T., Kelly, J. W., Lieberman, R. L. Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-β-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease Biochemistry 2011 50:10647-10657 DOI:10.1021/bi201619z PMID:22047104 PMCID:PMC3235649
- Price, J. L., Powers, E. T., Kelly, J. W. N-PEGylation of a reverse turn is stabilizing in multiple sequence contexts, unlike N-GlcNAcylation ACS Chemical Biology 2011 6:1188-1192 DOI:10.1021/cb200277u PMID:21939258 PMCID:PMC3220771
- Lee, J., Culyba, E. K., Powers, E. T., Kelly, J. W. Amyloid-beta forms fibrils by nucleated conformational conversion of oligomers Nature Chemical Biology 2011 7:602-609 DOI:10.1038/nchembio.624 PMID:21804535 PMCID:PMC3158298
- Alhamadsheh, M. M., Connelly, S., Cho, A., Reixach, N., Powers, E. T., Pan, D. W., Wilson, I. A., Kelly, J. W., Graef, I. A. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity Science Translational Medicine 2011 3:97ra81 DOI:10.1126/scitranslmed.3002473 PMID:21865539 PMCID:PMC3227540
- Price, J. L., Powers, D. L., Powers, E. T., Kelly, J. W. Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts Proceedings of the National Academy of Sciences of the United States of America 2011 108:14127-14132 DOI:10.1073/pnas.1105880108 PMID:21825145 PMCID:PMC3161607
- Groenning, M., Campos, R. I., Fagerberg, C., Rasmussen, A. A., Eriksen, U. H., Powers, E. T., Hammarstrom, P. Thermodynamic stability and denaturation kinetics of a benign natural transthyretin mutant identified in a danish kindred Amyloid-Journal of Protein Folding Disorders 2011 18:35-46 DOI:10.3109/13506129.2011.560215 PMID:21406045
- Solomon, J. P., Bourgault, S., Powers, E. T., Kelly, J. W. Heparin binds 8 kDa gelsolin cross-β-sheet oligomers and accelerates amyloidogenesis by hastening fibril extension Biochemistry 2011 50:2486-2498 DOI:10.1021/bi101905n PMID:21348501 PMCID:PMC3068913
- Powers, E. T., Balch, W. E. Protein folding: Protection from the outside Nature 2011 471:42-43 DOI:10.1038/471042a PMID:21368816
- Culyba, E. K., Price, J. L., Hanson, S. R., Dhar, A., Wong, C. H., Gruebele, M., Powers, E. T., Kelly, J. W. Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns Science 2011 331:571-575 DOI:10.1126/science.1198461 PMID:21292975 PMCID:PMC3099596
- Price, J. L., Shental-Bechor, D., Dhar, A., Turner, M. J., Powers, E. T., Gruebele, M., Levy, Y., Kelly, J. W. Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics Journal of the American Chemical Society 2010 132:15359-15367 DOI:10.1021/ja106896t PMID:20936810 PMCID:PMC2965790
- Solomon, J. P., Yonemoto, I. T., Murray, A. N., Price, J. L., Powers, E. T., Balch, W. E., Kelly, J. W. The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic Biochemistry 2009 48:11370-11380 DOI:10.1021/bi901368e PMID:19904968 PMCID:PMC2907741
- Usui, K., Hulleman, J. D., Paulsson, J. F., Siegel, S. J., Powers, E. T., Kelly, J. W. Site-specific modification of Alzheimer's peptides by cholesterol oxidation products enhances aggregation energetics and neurotoxicity Proceedings of the National Academy of Sciences of the United States of America 2009 106:18563-18568 DOI:10.1073/pnas.0804758106 PMID:19841277 PMCID:PMC2774025
- Hutt, D. M., Powers, E. T., Balch, W. E. The proteostasis boundary in misfolding diseases of membrane traffic FEBS Letters 2009 583:2639-2646 DOI:10.1016/j.febslet.2009.07.014 PMID:19708088 PMCID:PMC2805282
- Fuller, A. A., Du, D., Liu, F., Davoren, J. E., Bhabha, G., Kroon, G., Case, D. A., Dyson, H. J., Powers, E. T., Wipf, P., Gruebele, M., Kelly, J. W. Evaluating beta-turn mimics as beta-sheet folding nucleators Proceedings of the National Academy of Sciences of the United States of America 2009 106:11067-11072 DOI:10.1073/pnas.0813012106 PMID:19541614 PMCID:PMC2708776
- Gao, J. M., Bosco, D. A., Powers, E. T., Kelly, J. W. Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins Nature Structural & Molecular Biology 2009 16:684-690 DOI:10.1038/nsmb.1610 PMID:19525973 PMCID:PMC2754385
- Hanson, S. R., Culyba, E. K., Hsu, T. L., Wong, C. H., Kelly, J. W., Powers, E. T. The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability Proceedings of the National Academy of Sciences of the United States of America 2009 106:3131-3136 DOI:10.1073/pnas.0810318105 PMID:19204290 PMCID:PMC2651298
- Powers, E. T., Morimoto, R. I., Dillin, A., Kelly, J. W., Balch, W. E. Biological and chemical approaches to diseases of proteostasis deficiency Annual Review of Biochemistry 2009 78:959-991 DOI:10.1146/annurev.biochem.052308.114844 PMID:19298183
- Powers, E. T., Balch, W. E. Costly mistakes: translational infidelity and protein homeostasis Cell 2008 134:204-206 DOI:10.1016/j.cell.2008.07.005 PMID:18662533
- Babbes, A. R. H., Powers, E. T., Kelly, J. W. Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis Biochemistry 2008 47:6969-6984 DOI:10.1021/bi800636q PMID:18537267 PMCID:PMC2667099
- Powers, E. T., Powers, D. L. Mechanisms of protein fibril formation: Nucleated polymerization with competing off-pathway aggregation Biophysical Journal 2008 94:379-391 DOI:10.1529/biophysj.107.117168 PMID:17890392 PMCID:PMC2157252
- Jager, M., Deechongkit, S., Koepf, E. K., Nguyen, H., Gao, J. M., Powers, E. T., Gruebele, M., Kelly, J. W. Understanding the mechanism of beta-sheet folding from a chemical and biological perspective Biopolymers 2008 90:751-758 DOI:10.1002/bip.21101 PMID:18844292
- Wiseman, R. L., Powers, E. T., Buxbaum, J. N., Kelly, J. W., Balch, W. E. An adaptable standard for protein export from the endoplasmic reticulum Cell 2007 131:809-821 DOI:10.1016/j.cell.2007.10.025 PMID:18022373
- Wiseman, R. L., Koulov, A., Powers, E., Kelly, J. W., Balch, W. E. Protein energetics in maturation of the early secretory pathway Current Opinion in Cell Biology 2007 19:359-367 DOI:10.1016/j.ceb.2007.05.005 PMID:17686625 PMCID:PMC2094714
- Siegel, S. J., Bieschke, J., Powers, E. T., Kelly, J. W. The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation Biochemistry 2007 46:1503-1510 DOI:10.1021/bi061853s PMID:17279615 PMCID:PMC2530822
- Bieschke, J., Zhang, Q. H., Bosco, D. A., Lerner, R. A., Powers, E. T., Wentworth, P., Kelly, J. W. Small molecule oxidation products trigger disease-associated protein misfolding Accounts of Chemical Research 2006 39:611-619 DOI:10.1021/ar0500766 PMID:16981677
- Powers, E. T. The kinetics of nucleated polymerizations at high concentrations: Amyloid fibril formation near and above the "supercritical concentration'' Biophysical Journal 2006 91:122-132 DOI:10.1529/biophysj.105.073767 PMID:16603497 PMCID:PMC1479066
- Deechongkit, S., Nguyen, H., Jager, M., Powers, E. T., Gruebele, M., Kelly, J. W. Beta-sheet folding mechanisms from perturbation energetics Current Opinion in Structural Biology 2006 16:94-101 DOI:10.1016/j.sbi.2006.01.014 PMID:16442278
- Bosco, D. A., Fowler, D. M., Zhang, Q. H., Nieva, J., Powers, E. T., Wentworth, P., Lerner, R. A., Kelly, J. W. Elevated levels of oxidized cholesterol metabolites in lewy body disease brains accelerate alpha-synuclein fibrilization Nature Chemical Biology 2006 2:249-253 DOI:10.1038/nchembio782 PMID:16565714
- Wiseman, R. L., Powers, E. T., Kelly, J. W. Partitioning conformational intermediates between competing refolding and aggregation pathways: Insights into transthyretin amyloid disease Biochemistry 2005 44:16612-16623 DOI:10.1021/bi0511484 PMID:16342952 PMCID:PMC2532856
- Frankenfield, K. N., Powers, E. T., Kelly, J. W. Influence of the N-terminal domain on the aggregation properties of the prion protein Protein Science 2005 14:2154-2166 DOI:10.1110/ps.051434005 PMID:16046631 PMCID:PMC2279327
- Deechongkit, S., Powers, E. T., You, S. L., Kelly, J. W. Controlling the morphology of cross beta-sheet assemblies by rational design Journal of the American Chemical Society 2005 127:8562-8570 DOI:10.1021/ja050558c PMID:15941292
- Petrassi, H. M., Johnson, S. M., Purkey, H. E., Chiang, K. P., Walkup, T., Jiang, X., Powers, E. T., Kelly, J. W. Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: Kinetic stabilization of the native state Journal of the American Chemical Society 2005 127:6662-6671 DOI:10.1021/ja044351f PMID:15869287
- Bieschke, J., Zhang, Q. H., Powers, E. T., Lerner, R. A., Kelly, J. W. Oxidative metabolites accelerate Alzheimer's amyloidogenesis by a two-step mechanism, eliminating the requirement for nucleation Biochemistry 2005 44:4977-4983 DOI:10.1021/bi0501030 PMID:15794636
- Razavi, H., Powers, E. T., Purkey, H. E., Adamski-Werner, S. L., Chiang, K. P., Dendle, M. T. A., Kelly, J. W. Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors Bioorganic & Medicinal Chemistry Letters 2005 15:1075-1078 DOI:10.1016/j.bmcl.2004.12.022 PMID:15686915
- Powers, E. T., Deechongkit, S., Kelly, J. W. Backbone-backbone H-bonds make context-dependent contributions to protein folding kinetics and thermodynamics: lessons from amide-to-ester mutations Advances in Protein Chemistry 2005 72:39-78 DOI:10.1016/s0065-3233(05)72002-7 PMID:16581372
- Deechongkit, S., Nguyen, H., Powers, E. T., Dawson, P. E., Gruebele, M., Kelly, J. W. Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics Nature 2004 430:101-105 DOI:10.1038/nature02611 PMID:15229605
- Hurshman, A. R., White, J. T., Powers, E. T., Kelly, J. W. Transthyretin aggregation under partially denaturing conditions is a downhill polymerization Biochemistry 2004 43:7365-7381 DOI:10.1021/bi049621l PMID:15182180
- Zhang, Q. H., Powers, E. T., Nieva, J., Huff, M. E., Dendle, M. A., Bieschke, J., Glabe, C. G., Eschenmoser, A., Wentworth, P., Lerner, R. A., Kelly, J. W. Metabolite-initiated protein misfolding may trigger Alzheimer's disease Proceedings of the National Academy of Sciences of the United States of America 2004 101:4752-4757 DOI:10.1073/pnas.0400924101 PMID:15034169 PMCID:PMC387320
- Powers, E. T., Powers, D. L. A perspective on mechanisms of protein tetramer formation Biophysical Journal 2003 85:3587-3599 DOI:10.1016/s0006-3495(03)74777-8 PMID:14645052
- Lu, J. R., Perumal, S., Powers, E. T., Kelly, J. W., Webster, J. R. P., Penfold, J. Adsorption of beta-hairpin peptides on the surface of water: A neutron reflection study Journal of the American Chemical Society 2003 125:3751-3757 DOI:10.1021/ja0292290 PMID:12656605
- Colfer, S., Kelly, J. W., Powers, E. T. Factors governing the self-assembly of a beta-hairpin peptide at the air-water interface Langmuir 2003 19:1312-1318 DOI:10.1021/la0207668
- Hammarstrom, P.*, Wiseman, R. L.*, Powers, E. T., Kelly, J. W. Prevention of transthyretin amyloid disease by changing protein misfolding energetics Science 2003 299:713-716 DOI:10.1126/science.1079589 PMID:12560553 (* = equal contribution)
- DiDonato, M., Craig, L., Huff, M. E., Thayer, M. M., Cardoso, R. M. F., Kassmann, C. J., Lo, T. P., Bruns, C. K., Powers, E. T., Kelly, J. W., Getzoff, E. D., Tainer, J. A. ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization Journal of Molecular Biology 2003 332:601-615 DOI:10.1016/s0022-2836(03)00889-1 PMID:12963370
- Razavi, H., Palaninathan, S. K., Powers, E. T., Wiseman, R. L., Purkey, H. E., Mohamedmohaideen, N. N., Deechongkit, S., Chiang, K. P., Dendle, M. T. A., Sacchettini, J. C., Kelly, J. W. Benzoxazoles as transthyretin amyloid fibril inhibitors: Synthesis, evaluation, and mechanism of action Angewandte Chemie-International Edition 2003 42:2758-2761 DOI:10.1002/anie.200351179 PMID:12820260
- Hammarstrom, P., Jiang, X., Hurshman, A. R., Powers, E. T., Kelly, J. W. Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity Proceedings of the National Academy of Sciences of the United States of America 2002 99:16427-16432 DOI:10.1073/pnas.202495199 PMID:12351683 PMCID:PMC139904
- Oza, V. B., Smith, C., Raman, P., Koepf, E. K., Lashuel, H. A., Petrassi, H. M., Chiang, K. P., Powers, E. T., Sachettinni, J., Kelly, J. W. Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors Journal of Medicinal Chemistry 2002 45:321-332 DOI:10.1021/jm010257n PMID:11784137
- Powers, E. T., Yang, S. I., Lieber, C. M., Kelly, J. W. Ordered Langmuir-Blodgett films of amphiphilic beta-hairpin peptides imaged by atomic force microscopy Angewandte Chemie-International Edition 2002 41:127-130 DOI:10.1002/1521-3773(20020104)41:1<127::aid-anie127>3.0.co;2-f PMID:12491460
- Kaul, R., Angeles, A. R., Jager, M., Powers, E. T., Kelly, J. W. Incorporating beta-turns and a turn mimetic out of context in loop 1 of the WW domain affords cooperatively folded beta-sheets Journal of the American Chemical Society 2001 123:5206-5212 DOI:10.1021/ja0102890 PMID:11457382
- Powers, E. T., Kelly, J. W. Medium-dependent self-assembly of an amphiphilic peptide: Direct observation of peptide phase domains at the air-water interface Journal of the American Chemical Society 2001 123:775-776 DOI:10.1021/ja005528i PMID:11456608
- Zerkowski, J. A., Powers, E. T., Kemp, D. S. A permutation test for stabilization of polypeptide helices by sequence-dependent side chain interactions: Characterization of a helix initiation site within the myohemerythrin sequence 76-87 Journal of the American Chemical Society 1997 119:1153-1154 DOI:10.1021/ja962642l
- Rossi, F. M., Powers, E. T., Yoon, R., Rosenberg, L., Meinwald, J. Preparation of 2,3-diamino acids: Stereocontrolled synthesis of an aminated analog of the taxol side chain Tetrahedron 1996 52:10279-10286 DOI:10.1016/0040-4020(96)00562-5
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chapter
- Johnson, S. M., Wiseman, R. L., Reixach, N., Paulsson, J. F., Choi, S., Powers, E. T., Buxbaum, J. N., Kelly, J. W. Understanding and ameliorating the TTR amyloidoses Protein Misfolding Diseases. 967-1003. 2010 DOI:10.1002/9780470572702.ch45