recent publications
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academic article
- Strong, R., Miller, R. A., Bogue, M., Fernandez, E., Javors, M. A., Libert, S., Marinez, P. A., Murphy, M. P., Musi, N., Nelson, J. F., Petrascheck, M., Reifsnyder, P., et al. Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects Aging Cell 2020 19 DOI:10.1111/acel.13269 PMID:33145977 PMCID:PMC7681050
- Currais, A., Huang, L., Petrascheck, M., Maher, P., Schubert, D. A chemical biology approach to identifying molecular pathways associated with aging Geroscience 2020 DOI:10.1007/s11357-020-00238-5 PMID:32705410
- Perez-Gomez, A., Buxbaum, J. N., Petrascheck, M. The aging transcriptome: read between the lines Current Opinion in Neurobiology 2020 63:170-175 DOI:10.1016/j.conb.2020.05.001 PMID:32563038 PMCID:PMC7484127
- Currais, A., Huang, L., Goldberg, J., Petrascheck, M., Ates, G., Pinto-Duarte, A., Shokhirev, M. N., Schubert, D., Maher, P. Elevating acetyl-CoA levels reduces aspects of brain aging Elife 2019 8 DOI:10.7554/eLife.47866 PMID:31742554 PMCID:PMC6882557
- Chen, A. L., Lum, K. M., Lara-Gonzalez, P., Ogasawara, D., Cognetta III, A. B., To, A., Parsons, W. H., Simon, G. M., Desai, A., Petrascheck, M., Bar-Peled, L., Cravatt, B. F. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan Nature Chemical Biology 2019 15:453-462 DOI:10.1038/s41589-019-0243-4 PMID:30911178 PMCID:PMC6548519
- Ahuja, G., Bartsch, D., Yao, W., Geissen, S., Frank, S., Aguirre, A., Russ, N., Messling, J. E., Dodzian, J., Lagerborg, K. A., Vargas, N. E., Muck, J. S., et al. Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart EMBO Reports 2019 20 DOI:10.15252/embr.201847407 PMID:30886000 PMCID:PMC6446199
- Perez-Gomez, A., Carretero, M., Weber, N., Peterka, V., To, A., Titova, V., Solis, G., Osborn, O., Petrascheck, M. A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia Nature Communications 2018 9 DOI:10.1038/s41467-018-07684-y PMID:30532051 PMCID:PMC6288085
- Schubert, D., Currais, A., Goldberg, J., Finley, K., Petrascheck, M., Maher, P. Geroneuroprotectors: effective geroprotectors for the brain Trends in Pharmacological Sciences 2018 39:1004-1007 DOI:10.1016/j.tips.2018.09.008 PMID:30446211
- Solis, G. M., Kardakaris, R., Valentine, E. R., Bar-Peled, L., Chen, A. L., Blewett, M. M., McCormick, M. A., Williamson, J. R., Kennedy, B., Cravatt, B. F., Petrascheck, M. Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms Elife 2018 7 DOI:10.7554/eLife.40314 PMID:30479271 PMCID:PMC6257811
- Goldberg, J., Currais, A., Prior, M., Fischer, W., Chiruta, C., Ratliff, E., Daugherty, D., Dargusch, R., Finley, K., Esparza-Molto, P. B., Cuezva, J. M., Maher, P., et al. The mitochondrial ATP synthase is a shared drug target for aging and dementia Aging Cell 2018 17 DOI:10.1111/acel.12715 PMID:29316249 PMCID:PMC5847861
- Barardo, D., Thornton, D., Thoppil, H., Walsh, M., Sharifi, S., Ferreira, S., Anzic, A., Fernandes, M., Monteiro, P., Grum, T., Cordeiro, R., De-Souza, E. A., et al. The DrugAge database of aging-related drugs Aging Cell 2017 16:594-597 DOI:10.1111/acel.12585 PMID:28299908 PMCID:PMC5418190
- Carretero, M., Solis, G. M., Petrascheck, M. C. elegans as model for drug discovery Current Topics in Medicinal Chemistry 2017 17:2067-2076 DOI:10.2174/1568026617666170131114401 PMID:28137208
- Rangaraju, S., Levey, D. F., Nho, K., Jain, N., Andrews, K. D., Le-Niculescu, H., Salomon, D. R., Saykin, A. J., Petrascheck, M., Niculescu, A. B. Mood, stress and longevity: convergence on ANK3 Molecular Psychiatry 2016 21:1037-1049 DOI:10.1038/mp.2016.65 PMID:27217151
- Yepuri, G., Sukhovershin, R., Nazari-Shafti, T. Z., Petrascheck, M., Ghebre, Y. T., Cooke, J. P. Proton pump inhibitors accelerate endothelial senescence Circulation Research 2016 118:E36-E42 DOI:10.1161/circresaha.116.308807 PMID:27166251 PMCID:PMC4902745
- Ivanisevic, J., Stauch, K. L., Petrascheck, M., Benton, H. P., Epstein, A. A., Fang, M., Gorantla, S., Tran, M., Hoang, L., Kurczy, M. E., Boska, M. D., Gendelman, H. E., et al. Metabolic drift in the aging brain Aging 2016 8:1000-1020 DOI:10.18632/aging.100961 PMID:27182841 PMCID:PMC4931850
- McQuary, P. R., Liao, C. Y., Chang, J. T., Kumsta, C., She, X., Davis, A., Chu, C. C., Gelino, S., Gomez-Amaro, R. L., Petrascheck, M., Brill, L. M., Ladiges, W. C., et al. C. elegans S6K mutants require a creatine-kinase-like effector for lifespan extension Cell Reports 2016 14:2059-2067 DOI:10.1016/j.celrep.2016.02.012 PMID:26923601 PMCID:PMC4823261
- Rangaraju, S., Solis, G. M., Andersson, S. I., Gomez-Amaro, R. L., Kardakaris, R., Broaddus, C. D., Niculescu III, A. B., Petrascheck, M. Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response Aging Cell 2015 14:971-981 DOI:10.1111/acel.12379 PMID:26255886 PMCID:PMC4693466
- Rangaraju, S., Solis, G. M., Thompson, R. C., Gomez-Amaro, R. L., Kurian, L., Encalada, S. E., Niculescu, A. B., Salomon, D. R., Petrascheck, M. Suppression of transcriptional drift extends C-elegans lifespan by postponing the onset of mortality Elife 2015 4:e08833 DOI:10.7554/eLife.08833 PMID:26623667 PMCID:PMC4720515
- Gomez-Amaro, R. L., Valentine, E. R., Carretero, M., LeBoeuf, S. E., Rangaraju, S., Broaddus, C. D., Solis, G. M., Williamson, J. R., Petrascheck, M. Measuring food intake and nutrient absorption in Caenorhabditis elegans Genetics 2015 200:443-454 DOI:10.1534/genetics.115.175851 PMID:25903497 PMCID:PMC4492371
- Carretero, M., Gomez-Amaro, R. L., Petrascheck, M. Pharmacological classes that extend lifesapn of Caenorhabditis elegans Frontiers in Genetics 2015 6 DOI:10.3389/fgene.2015.00077 PMID:25784926
- Chin, R. M., Fu, X., Pai, M. Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V. S., Monsalve, G. C., Hu, E., Whelan, S. A., et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR Nature 2014 510:397-401 DOI:10.1038/nature13264 PMID:24828042 PMCID:PMC4263271
- Ye, X., Linton, J. M., Schork, N. J., Buck, L. B., Petrascheck, M. A pharmacological network for lifespan extension in Caenorhabditis elegans Aging Cell 2014 13:206-215 DOI:10.1111/acel.12163 PMID:24134630 PMCID:PMC3955372
- Solis, G. M., Petrascheck, M. Measuring Caenorhabditis elegans life span in 96 well microtiter plates Journal of Visualized Experiments : JoVE 2011 DOI:10.3791/2496 PMID:21445049 PMCID:PMC3197298
- Petrascheck, M., Ye, X., Buck, L. B. A High-Throughput Screen for Chemicals that Increase the Lifespan of Caenorhabditis elegans Annals of the New York Academy of Sciences 2009 1170:698-701 DOI:10.1111/j.1749-6632.2009.04377.x PMID:19686215
- Petrascheck, M., Ye, X. L., Buck, L. B. An antidepressant that extends lifespan in adult caenorhabditis elegans Nature 2007 450:553-556 DOI:10.1038/nature05991 PMID:18033297
- Petrascheck, M., Escher, D., Mahmoudi, T., Verrijzer, C. P., Schaffner, W., Barberis, A. DNA looping induced by a transcriptional enhancer in vivo Nucleic Acids Research 2005 33:3743-3750 DOI:10.1093/nar/gki689 PMID:16002789 PMCID:PMC1174898
- Gunde, T., Tanner, S., der Maur, A. A., Petrascheck, M., Barberis, A. Quenching accumulation of toxic galactose-1-phosphate as a system to select disruption of protein-protein interactions in vivo Biotechniques 2004 37:844-852 PMID:15560141
- Sieber, P., Petrascheck, M., Barberis, A., Schneitz, K. Organ polarity in arabidopsis. Nozzle physically interacts with members of the yabby family Plant Physiology 2004 135:2172-2185 DOI:10.1104/pp.104.040154 PMID:15299139 PMCID:PMC520788
- Petrascheck, M., Castagna, F., Barberis, A. Two-hybrid selection assay to identify proteins interacting with polymerase ii transcription factors and regulators Biotechniques 2001 30:296-298, 300, 302 PMID:11233598
