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Petrascheck, Michael
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Petrascheck, Michael

Faculty Member
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Positions

  • 2017 - Associate Professor (Joint Appointment), Neuroscience , Scripps Research
  • 2017 - Associate Professor (Joint Appointment), Dorris Neuroscience Center , Scripps Research
  • 2017 - Associate Professor, Molecular Medicine , Scripps Research
  • 2009 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2017 Assistant Professor (Joint Appointment), Neuroscience , Scripps Research
  • 2017 Assistant Professor, Molecular Medicine , Scripps Research
  • 2013 - 2017 Assistant Professor (Joint Appointment), Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2010 - 2017 Assistant Professor (Joint Appointment), Dorris Neuroscience Center , Scripps Research
  • 2009 - 2017 Assistant Professor, Chemical Physiology , Scripps Research
  • 2002 - 2009 Postdoctoral Fellow with Dr. Linda Buck, Fred Hutchinson Cancer Research Center
  • 2002 Staff Scientist, ESBATech
Dr. Michael Petrascheck studies the connection between aging and age-related disease by testing small molecules that have been found to increase lifespan in C.elegans for effects on various models of age-related disease.

Contact

  • pscheck@scripps.edu

Websites

  • Michael Petrascheck, Ph.D.
  • Laboratory Website
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  • Background
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Publications

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  • Publications without PubMed PMIDs

  • academic article

    • Strong, R., Miller, R. A., Bogue, M., Fernandez, E., Javors, M. A., Libert, S., Marinez, P. A., Murphy, M. P., Musi, N., Nelson, J. F., Petrascheck, M., Reifsnyder, P., et al. Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects Aging Cell  2020 19  DOI:10.1111/acel.13269  PMID:33145977  PMCID:PMC7681050
    • Currais, A., Huang, L., Petrascheck, M., Maher, P., Schubert, D. A chemical biology approach to identifying molecular pathways associated with aging Geroscience  2020  DOI:10.1007/s11357-020-00238-5  PMID:32705410
    • Perez-Gomez, A., Buxbaum, J. N., Petrascheck, M. The aging transcriptome: read between the lines Current Opinion in Neurobiology  2020 63:170-175  DOI:10.1016/j.conb.2020.05.001  PMID:32563038  PMCID:PMC7484127
    • Currais, A., Huang, L., Goldberg, J., Petrascheck, M., Ates, G., Pinto-Duarte, A., Shokhirev, M. N., Schubert, D., Maher, P. Elevating acetyl-CoA levels reduces aspects of brain aging Elife  2019 8  DOI:10.7554/eLife.47866  PMID:31742554  PMCID:PMC6882557
    • Chen, A. L., Lum, K. M., Lara-Gonzalez, P., Ogasawara, D., Cognetta III, A. B., To, A., Parsons, W. H., Simon, G. M., Desai, A., Petrascheck, M., Bar-Peled, L., Cravatt, B. F. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan Nature Chemical Biology  2019 15:453-462  DOI:10.1038/s41589-019-0243-4  PMID:30911178  PMCID:PMC6548519
    • Ahuja, G., Bartsch, D., Yao, W., Geissen, S., Frank, S., Aguirre, A., Russ, N., Messling, J. E., Dodzian, J., Lagerborg, K. A., Vargas, N. E., Muck, J. S., et al. Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart EMBO Reports  2019 20  DOI:10.15252/embr.201847407  PMID:30886000  PMCID:PMC6446199
    • Perez-Gomez, A., Carretero, M., Weber, N., Peterka, V., To, A., Titova, V., Solis, G., Osborn, O., Petrascheck, M. A phenotypic Caenorhabditis elegans screen identifies a selective suppressor of antipsychotic-induced hyperphagia Nature Communications  2018 9  DOI:10.1038/s41467-018-07684-y  PMID:30532051  PMCID:PMC6288085
    • Schubert, D., Currais, A., Goldberg, J., Finley, K., Petrascheck, M., Maher, P. Geroneuroprotectors: effective geroprotectors for the brain Trends in Pharmacological Sciences  2018 39:1004-1007  DOI:10.1016/j.tips.2018.09.008  PMID:30446211
    • Solis, G. M., Kardakaris, R., Valentine, E. R., Bar-Peled, L., Chen, A. L., Blewett, M. M., McCormick, M. A., Williamson, J. R., Kennedy, B., Cravatt, B. F., Petrascheck, M. Translation attenuation by minocycline enhances longevity and proteostasis in old post-stress-responsive organisms Elife  2018 7  DOI:10.7554/eLife.40314  PMID:30479271  PMCID:PMC6257811
    • Goldberg, J., Currais, A., Prior, M., Fischer, W., Chiruta, C., Ratliff, E., Daugherty, D., Dargusch, R., Finley, K., Esparza-Molto, P. B., Cuezva, J. M., Maher, P., et al. The mitochondrial ATP synthase is a shared drug target for aging and dementia Aging Cell  2018 17  DOI:10.1111/acel.12715  PMID:29316249  PMCID:PMC5847861
    • Barardo, D., Thornton, D., Thoppil, H., Walsh, M., Sharifi, S., Ferreira, S., Anzic, A., Fernandes, M., Monteiro, P., Grum, T., Cordeiro, R., De-Souza, E. A., et al. The DrugAge database of aging-related drugs Aging Cell  2017 16:594-597  DOI:10.1111/acel.12585  PMID:28299908  PMCID:PMC5418190
    • Carretero, M., Solis, G. M., Petrascheck, M. C. elegans as model for drug discovery Current Topics in Medicinal Chemistry  2017 17:2067-2076  DOI:10.2174/1568026617666170131114401  PMID:28137208
    • Rangaraju, S., Levey, D. F., Nho, K., Jain, N., Andrews, K. D., Le-Niculescu, H., Salomon, D. R., Saykin, A. J., Petrascheck, M., Niculescu, A. B. Mood, stress and longevity: convergence on ANK3 Molecular Psychiatry  2016 21:1037-1049  DOI:10.1038/mp.2016.65  PMID:27217151
    • Yepuri, G., Sukhovershin, R., Nazari-Shafti, T. Z., Petrascheck, M., Ghebre, Y. T., Cooke, J. P. Proton pump inhibitors accelerate endothelial senescence Circulation Research  2016 118:E36-E42  DOI:10.1161/circresaha.116.308807  PMID:27166251  PMCID:PMC4902745
    • Ivanisevic, J., Stauch, K. L., Petrascheck, M., Benton, H. P., Epstein, A. A., Fang, M., Gorantla, S., Tran, M., Hoang, L., Kurczy, M. E., Boska, M. D., Gendelman, H. E., et al. Metabolic drift in the aging brain Aging  2016 8:1000-1020  DOI:10.18632/aging.100961  PMID:27182841  PMCID:PMC4931850
    • McQuary, P. R., Liao, C. Y., Chang, J. T., Kumsta, C., She, X., Davis, A., Chu, C. C., Gelino, S., Gomez-Amaro, R. L., Petrascheck, M., Brill, L. M., Ladiges, W. C., et al. C. elegans S6K mutants require a creatine-kinase-like effector for lifespan extension Cell Reports  2016 14:2059-2067  DOI:10.1016/j.celrep.2016.02.012  PMID:26923601  PMCID:PMC4823261
    • Rangaraju, S., Solis, G. M., Andersson, S. I., Gomez-Amaro, R. L., Kardakaris, R., Broaddus, C. D., Niculescu III, A. B., Petrascheck, M. Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non-cell-autonomous stress response Aging Cell  2015 14:971-981  DOI:10.1111/acel.12379  PMID:26255886  PMCID:PMC4693466
    • Rangaraju, S., Solis, G. M., Thompson, R. C., Gomez-Amaro, R. L., Kurian, L., Encalada, S. E., Niculescu, A. B., Salomon, D. R., Petrascheck, M. Suppression of transcriptional drift extends C-elegans lifespan by postponing the onset of mortality Elife  2015 4:e08833  DOI:10.7554/eLife.08833  PMID:26623667  PMCID:PMC4720515
    • Gomez-Amaro, R. L., Valentine, E. R., Carretero, M., LeBoeuf, S. E., Rangaraju, S., Broaddus, C. D., Solis, G. M., Williamson, J. R., Petrascheck, M. Measuring food intake and nutrient absorption in Caenorhabditis elegans Genetics  2015 200:443-454  DOI:10.1534/genetics.115.175851  PMID:25903497  PMCID:PMC4492371
    • Carretero, M., Gomez-Amaro, R. L., Petrascheck, M. Pharmacological classes that extend lifesapn of Caenorhabditis elegans Frontiers in Genetics  2015 6  DOI:10.3389/fgene.2015.00077  PMID:25784926
    • Chin, R. M., Fu, X., Pai, M. Y., Vergnes, L., Hwang, H., Deng, G., Diep, S., Lomenick, B., Meli, V. S., Monsalve, G. C., Hu, E., Whelan, S. A., et al. The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR Nature  2014 510:397-401  DOI:10.1038/nature13264  PMID:24828042  PMCID:PMC4263271
    • Ye, X., Linton, J. M., Schork, N. J., Buck, L. B., Petrascheck, M. A pharmacological network for lifespan extension in Caenorhabditis elegans Aging Cell  2014 13:206-215  DOI:10.1111/acel.12163  PMID:24134630  PMCID:PMC3955372
    • Solis, G. M., Petrascheck, M. Measuring Caenorhabditis elegans life span in 96 well microtiter plates Journal of Visualized Experiments : JoVE  2011  DOI:10.3791/2496  PMID:21445049  PMCID:PMC3197298
    • Petrascheck, M., Ye, X., Buck, L. B. A High-Throughput Screen for Chemicals that Increase the Lifespan of Caenorhabditis elegans Annals of the New York Academy of Sciences  2009 1170:698-701  DOI:10.1111/j.1749-6632.2009.04377.x  PMID:19686215
    • Petrascheck, M., Ye, X. L., Buck, L. B. An antidepressant that extends lifespan in adult caenorhabditis elegans Nature  2007 450:553-556  DOI:10.1038/nature05991  PMID:18033297
    • Petrascheck, M., Escher, D., Mahmoudi, T., Verrijzer, C. P., Schaffner, W., Barberis, A. DNA looping induced by a transcriptional enhancer in vivo Nucleic Acids Research  2005 33:3743-3750  DOI:10.1093/nar/gki689  PMID:16002789  PMCID:PMC1174898
    • Gunde, T., Tanner, S., der Maur, A. A., Petrascheck, M., Barberis, A. Quenching accumulation of toxic galactose-1-phosphate as a system to select disruption of protein-protein interactions in vivo Biotechniques  2004 37:844-852  PMID:15560141
    • Sieber, P., Petrascheck, M., Barberis, A., Schneitz, K. Organ polarity in arabidopsis. Nozzle physically interacts with members of the yabby family Plant Physiology  2004 135:2172-2185  DOI:10.1104/pp.104.040154  PMID:15299139  PMCID:PMC520788
    • Petrascheck, M., Castagna, F., Barberis, A. Two-hybrid selection assay to identify proteins interacting with polymerase ii transcription factors and regulators Biotechniques  2001 30:296-298, 300, 302  PMID:11233598

featured in

  • Two Scripps Research Scientists Receive $1.5 Million NIH Innovator Awards  Newsletter
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Research

research overview

  • Old age is accompanied by a deterioration of tissues and organs, increased susceptibility to disease, and an exponential increase in mortality. The last years have seen great progress in unraveling the mechanisms underlying aging. It has become clear that aging is regulated by various genetic pathways which when properly manipulated lead to increases in lifespan. These findings raise the exciting possibility that age related diseases could be treated by targeting aging pathways instead of the disease itself.

    To investigate this possibility we have screened for small molecules that extend lifespan in C.elegans. The power of the small molecule approach lies in its enormous flexibility. Small molecules can be tested in cell lines, various model organisms, different models of age related disease, in combination with each other, or in combination with mutations known to affect aging and lifespan. Using life-extending small molecules as probes we can now start to investigate the molecular connection between aging and age-related diseases.
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Teaching

advisees

  • graduate advising relationship

    • Clay, Khalyd, Ph.D.  candidate, 2018 -
    • Solis, Gregory, Ph.D.  candidate, 2013 - 2018
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Background

education and training

  • Ph.D. in Molecular Biology, University of Zurich , Institute of Molecular Biology, with Dr. Alcide Barberis and Dr. Walter Schaffner 2001

awards and honors

  • Faculty of 1000 Biology: evaluations for Petrascheck M et al Nature 2007 Nov 22 450 (7169) :553-6, 2007
  • Faculty of 1000 Biology: evaluations for Petrascheck M et al Nucleic Acids Res 2005 33 (12) :3743-50, 2005
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Contact

full name

  • Michael Petrascheck

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0002-1010-145X

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