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Paxman, Ryan
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Paxman, Ryan

Graduate Student
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Publications

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  • academic article

    • degree-related publication Rius, B., Mesgarzadeh, J. S., Romine, I. C., Paxman, R. J., Kelly, J. W., Wiseman, R. L. Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion Blood Advances  2021 5:1037-1049  DOI:10.1182/bloodadvances.2020002813  PMID:33599742  PMCID:PMC7903236
    • degree-related publication Grandjean, J. M. D., Madhavan, A., Cech, L., Seguinot, B. O., Paxman, R. J., Smith, E., Scampavia, L., Powers, E. T., Cooley, C. B., Plate, L., Spicer, T. P., Kelly, J. W., et al. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming Nature Chemical Biology  2020  DOI:10.1038/s41589-020-0584-z  PMID:32690944
    • degree-related publication Nelson, L. T., Paxman, R. J., Xu, J., Webb, B., Powers, E. T., Kelly, J. W. Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma Amyloid-Journal of Protein Folding Disorders  2020  DOI:10.1080/13506129.2020.1808783  PMID:32811187
    • degree-related publication Blackwood, E. A., Azizi, K., Thuerauf, D. J., Paxman, R. J., Plate, L., Kelly, J. W., Wiseman, R. L., Glembotski, C. C. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis Nature Communications  2019 10  DOI:10.1038/s41467-018-08129-2  PMID:30643122  PMCID:PMC6331617
    • degree-related publication Paxman, R., Plate, L., Blackwood, E. A., Glembotski, C., Powers, E. T., Wiseman, R. L., Kelly, J. W. Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins Elife  2018 7  DOI:10.7554/eLife.37168  PMID:30084354  PMCID:PMC6080950
    • degree-related publication Kroeger, H., Grimsey, N., Paxman, R., Chiang, W. C., Plate, L., Jones, Y., Shaw, P. X., Trejo, J., Tsang, S. H., Powers, E., Kelly, J. W., Wiseman, R. L., et al. The unfolded protein response regulator ATF6 promotes mesodermal differentiation Science Signaling  2018 11  DOI:10.1126/scisignal.aan5785  PMID:29440509
    • degree-related publication Plate, L., Paxman, R. J., Wiseman, R. L., Kelly, J. W. Modulating protein quality control Elife  2016 5  DOI:10.7554/eLife.18431  PMID:27435959  PMCID:PMC4954752
    • degree-related publication Plate, L., Cooley, C. B., Chen, J. J., Paxman, R. J., Gallagher, C. M., Madoux, F., Genereux, J. C., Dobbs, W., Garza, D., Spicer, T. P., Scampavia, L., Brown, S. J., et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Elife  2016 5  DOI:10.7554/eLife.15550  PMID:27435961  PMCID:PMC4954754
    • Lawrence, P. B., Gavrilov, Y., Matthews, S. S., Langlois, M. I., Shental-Bechor, D., Greenblatt, H. M., Pandey, B. K., Smith, M. S., Paxman, R., Torgerson, C. D., Merrell, J. P., Ritz, C. C., et al. Criteria for selecting PEGylation sites on proteins for higher thermodynamic and proteolytic stability Journal of the American Chemical Society  2014 136:17547-17560  DOI:10.1021/ja5095183  PMID:25409346
    • Chao, S. H., Matthews, S. S., Paxman, R., Aksimentiev, A., Gruebele, M., Price, J. L. Two structural scenarios for protein stabilization by PEG Journal of Physical Chemistry B  2014 118:8388-8395  DOI:10.1021/jp502234s  PMID:24821319
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Background

education and training

  • Ph.D. in Chemical Biology, Scripps Research 2014 -
  • B.S. in Biochemistry, Brigham Young University 2008 - 2014

advisee of

  • graduate advising relationship

    • Kelly, Jeffery, Ph.D.  candidacy, 2015 -
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Contact

full name

  • Ryan James Paxman

geographic location

  • Scripps California 

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