recent publications
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academic article
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Rius, B., Mesgarzadeh, J. S., Romine, I. C., Paxman, R. J., Kelly, J. W., Wiseman, R. L.
Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion
Blood Advances
2021
5:1037-1049
DOI:10.1182/bloodadvances.2020002813
PMID:33599742
PMCID:PMC7903236
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Grandjean, J. M. D., Madhavan, A., Cech, L., Seguinot, B. O., Paxman, R. J., Smith, E., Scampavia, L., Powers, E. T., Cooley, C. B., Plate, L., Spicer, T. P., Kelly, J. W., et al.
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
Nature Chemical Biology
2020
DOI:10.1038/s41589-020-0584-z
PMID:32690944
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Nelson, L. T., Paxman, R. J., Xu, J., Webb, B., Powers, E. T., Kelly, J. W.
Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma
Amyloid-Journal of Protein Folding Disorders
2020
DOI:10.1080/13506129.2020.1808783
PMID:32811187
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Blackwood, E. A., Azizi, K., Thuerauf, D. J., Paxman, R. J., Plate, L., Kelly, J. W., Wiseman, R. L., Glembotski, C. C.
Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis
Nature Communications
2019
10
DOI:10.1038/s41467-018-08129-2
PMID:30643122
PMCID:PMC6331617
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Paxman, R., Plate, L., Blackwood, E. A., Glembotski, C., Powers, E. T., Wiseman, R. L., Kelly, J. W.
Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins
Elife
2018
7
DOI:10.7554/eLife.37168
PMID:30084354
PMCID:PMC6080950
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Kroeger, H., Grimsey, N., Paxman, R., Chiang, W. C., Plate, L., Jones, Y., Shaw, P. X., Trejo, J., Tsang, S. H., Powers, E., Kelly, J. W., Wiseman, R. L., et al.
The unfolded protein response regulator ATF6 promotes mesodermal differentiation
Science Signaling
2018
11
DOI:10.1126/scisignal.aan5785
PMID:29440509
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Plate, L., Paxman, R. J., Wiseman, R. L., Kelly, J. W.
Modulating protein quality control
Elife
2016
5
DOI:10.7554/eLife.18431
PMID:27435959
PMCID:PMC4954752
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Plate, L., Cooley, C. B., Chen, J. J., Paxman, R. J., Gallagher, C. M., Madoux, F., Genereux, J. C., Dobbs, W., Garza, D., Spicer, T. P., Scampavia, L., Brown, S. J., et al.
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
Elife
2016
5
DOI:10.7554/eLife.15550
PMID:27435961
PMCID:PMC4954754
- Lawrence, P. B., Gavrilov, Y., Matthews, S. S., Langlois, M. I., Shental-Bechor, D., Greenblatt, H. M., Pandey, B. K., Smith, M. S., Paxman, R., Torgerson, C. D., Merrell, J. P., Ritz, C. C., et al. Criteria for selecting PEGylation sites on proteins for higher thermodynamic and proteolytic stability Journal of the American Chemical Society 2014 136:17547-17560 DOI:10.1021/ja5095183 PMID:25409346
- Chao, S. H., Matthews, S. S., Paxman, R., Aksimentiev, A., Gruebele, M., Price, J. L. Two structural scenarios for protein stabilization by PEG Journal of Physical Chemistry B 2014 118:8388-8395 DOI:10.1021/jp502234s PMID:24821319
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