recent publications
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academic article
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Rius, B., Mesgarzadeh, J. S., Romine, I. C., Paxman, R. J., Kelly, J. W., Wiseman, R. L. Pharmacologic targeting of plasma cell endoplasmic reticulum proteostasis to reduce amyloidogenic light chain secretion Blood Advances 2021 5:1037-1049 DOI:10.1182/bloodadvances.2020002813 PMID:33599742 PMCID:PMC7903236
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Grandjean, J. M. D., Madhavan, A., Cech, L., Seguinot, B. O., Paxman, R. J., Smith, E., Scampavia, L., Powers, E. T., Cooley, C. B., Plate, L., Spicer, T. P., Kelly, J. W., et al. Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming Nature Chemical Biology 2020 DOI:10.1038/s41589-020-0584-z PMID:32690944
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Nelson, L. T., Paxman, R. J., Xu, J., Webb, B., Powers, E. T., Kelly, J. W. Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma Amyloid-Journal of Protein Folding Disorders 2020 DOI:10.1080/13506129.2020.1808783 PMID:32811187
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Blackwood, E. A., Azizi, K., Thuerauf, D. J., Paxman, R. J., Plate, L., Kelly, J. W., Wiseman, R. L., Glembotski, C. C. Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis Nature Communications 2019 10 DOI:10.1038/s41467-018-08129-2 PMID:30643122 PMCID:PMC6331617
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Paxman, R., Plate, L., Blackwood, E. A., Glembotski, C., Powers, E. T., Wiseman, R. L., Kelly, J. W. Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins Elife 2018 7 DOI:10.7554/eLife.37168 PMID:30084354 PMCID:PMC6080950
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Kroeger, H., Grimsey, N., Paxman, R., Chiang, W. C., Plate, L., Jones, Y., Shaw, P. X., Trejo, J., Tsang, S. H., Powers, E., Kelly, J. W., Wiseman, R. L., et al. The unfolded protein response regulator ATF6 promotes mesodermal differentiation Science Signaling 2018 11 DOI:10.1126/scisignal.aan5785 PMID:29440509
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Plate, L., Paxman, R. J., Wiseman, R. L., Kelly, J. W. Modulating protein quality control Elife 2016 5 DOI:10.7554/eLife.18431 PMID:27435959 PMCID:PMC4954752
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Plate, L., Cooley, C. B., Chen, J. J., Paxman, R. J., Gallagher, C. M., Madoux, F., Genereux, J. C., Dobbs, W., Garza, D., Spicer, T. P., Scampavia, L., Brown, S. J., et al. Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation Elife 2016 5 DOI:10.7554/eLife.15550 PMID:27435961 PMCID:PMC4954754
- Lawrence, P. B., Gavrilov, Y., Matthews, S. S., Langlois, M. I., Shental-Bechor, D., Greenblatt, H. M., Pandey, B. K., Smith, M. S., Paxman, R., Torgerson, C. D., Merrell, J. P., Ritz, C. C., et al. Criteria for selecting PEGylation sites on proteins for higher thermodynamic and proteolytic stability Journal of the American Chemical Society 2014 136:17547-17560 DOI:10.1021/ja5095183 PMID:25409346
- Chao, S. H., Matthews, S. S., Paxman, R., Aksimentiev, A., Gruebele, M., Price, J. L. Two structural scenarios for protein stabilization by PEG Journal of Physical Chemistry B 2014 118:8388-8395 DOI:10.1021/jp502234s PMID:24821319
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