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Pauthner, Matthias

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• 2017 - Postdoctoral Research Associate, Scripps Research

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  • Carnathan, D. G., Kaushik, K., Ellebedy, A. H., Enemuo, C. A., Gebru, E. H., Dhadvai, P., Rasheed, M. A. U., Pauthner, M. G., Ozorowski, G., Ahmed, R., Burton, D. R., Ward, A. B., et al. Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers Frontiers in Immunology  2020 11  DOI:10.3389/fimmu.2020.01213  PMID:32612608  PMCID:PMC7308430
  • Nogal, B., McCoy, L. E., van Gils, M. J., Cottrell, C. A., Voss, J. E., Andrabi, R., Pauthner, M., Liang, C. H., Messmer, T., Nedellec, R., Shin, M., Turner, H. L., et al. HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite Science Advances  2020 6  DOI:10.1126/sciadv.aba0512  PMID:32548265  PMCID:PMC7274786
  • Yang, Y. H. R., McCoy, L. E., van Gils, M. J., Andrabi, R., Turner, H. L., Yuan, M., Cottrell, C. A., Ozorowski, G., Voss, J., Pauthner, M., Polveroni, T. M., Messmer, T., et al. Autologous antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits Journal of Virology  2020 94  DOI:10.1128/jvi.01861-19  PMID:31941772  PMCID:PMC7081899
  • Pedreno-Lopez, N., Dang, C. M., Rosen, B. C., Ricciardi, M. J., Bailey, V. K., Gutman, M. J., Gonzalez-Nieto, L., Pauthner, M. G., Le, K., Song, G., Andrabi, R., Weisgrau, K. L., et al. Induction of transient virus replication facilitates antigen-independent isolation of SIV-specific monoclonal antibodies Molecular Therapy-Methods & Clinical Development  2020 16:225-237  DOI:10.1016/j.omtm.2020.01.010  PMID:32083148  PMCID:PMC7021589
  • Zhao, F., Joyce, C., Burns, A., Nogal, B., Cottrell, C. A., Ramos, A., Biddle, T., Pauthner, M., Nedellec, R., Qureshi, H., Mason, R., Landais, E., et al. Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques Cell Reports  2020 32  DOI:10.1016/j.celrep.2020.108122  PMID:32905766  PMCID:PMC7487785
  • Martins, Mauricio A., Gonzalez-Nieto, Lucas, Ricciardi, Michael J., Bailey, Varian K., Dang, Christine M., Bischof, Georg F., Pedreno-Lopez, Nuria, Pauthner, M., Burton, D., Parks, Christopher L., Earl, Patricia and Moss, Bernard, Rakasz, Eva G., et al. Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome Journal of Virology  2020 94  DOI:10.1128/jvi.00979-20  PMID:33028714  PMCID:PMC7925177
  • Pegu, A., Borate, B., Huang, Y., Pauthner, M. G., Hessell, A. J., Julg, B., Doria-Rose, N. A., Schmidt, S. D., Carpp, L. N., Cully, M. D., Chen, X., Shaw, G. M., et al. A meta-analysis of passive immunization studies shows that serum-neutralizing antibody titer associates with protection against SHIV challenge Cell Host & Microbe  2019 26:336-346  DOI:10.1016/j.chom.2019.08.014  PMID:31513771  PMCID:PMC6755677
  • Andrabi, R., Pallesen, J., Allen, J. D., Song, G., Zhang, J., de Val, N., Gegg, G., Porter, K., Su, C., Pauthner, M., Newman, A., Bouton-Verville, H., et al. The chimpanzee SIV envelope trimer: structure and deployment as an HIV vaccine template Cell Reports  2019 27:2426-2441  DOI:10.1016/j.celrep.2019.04.082  PMID:31116986  PMCID:PMC6533203
  • Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Nakao, C., Pauthner, M. G., et al. Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance Cell  2019 177:1153-1171  DOI:10.1016/j.cell.2019.04.012  PMID:31080066
  • Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers Immunity  2019 50:241-252  DOI:10.1016/j.immuni.2018.11.011  PMID:30552025  PMCID:PMC6335502
  • Cao, L. W., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J. K., Menis, S., Sok, D., Bastidas, R., Park, S. K. R., Delahunty, C. M., He, L., et al. Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer Nature Communications  2018 9  DOI:10.1038/s41467-018-06121-4  PMID:30209313  PMCID:PMC6135743
  • Bianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M., Bastidas, R., Nedellec, R., McCoy, L. E., Wilson, I. A., Burton, D. R., Ward, A. B., et al. Electron-microscopy-based epitope mapping defines specificities of polyclonal antibodies elicited during HIV-1 BG505 envelope trimer immunization Immunity  2018 49:288-300  DOI:10.1016/j.immuni.2018.07.009  PMID:30097292  PMCID:PMC6104742
  • Martins, M. A., Tully, D. C., Pedreno-Lopez, N., von Bredow, B., Pauthner, M. G., Shin, Y. C., Yuan, M. L., Lima, N. S., Bean, D. J., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., et al. Mamu-B*17(+) rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication Journal of Virology  2018 92:e00690-18  DOI:10.1128/jvi.00690-18  PMID:29875239  PMCID:PMC6069176
  • Cao, L., Diedrich, J. K., Ma, Y., Wang, N., Pauthner, M., Park, S. K. R., Delahunty, C. M., McLellan, J. S., Burton, D. R., Yates III, J. R., Paulson, J. C. Global site-specific analysis of glycoprotein N-glycan processing Nature Protocols  2018 13:1196-1212  DOI:10.1038/nprot.2018.024  PMID:29725121  PMCID:PMC5941933
  • Kulp, D. W., Steichen, J. M., Pauthner, M., Hu, X., Schiffner, T., Liguori, A., Cottrell, C. A., Havenar-Daughton, C., Ozorowski, G., Georgeson, E., Kalyuzhniy, O., Willis, J. R., et al. Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding Nature Communications  2017 8  DOI:10.1038/s41467-017-01549-6  PMID:29162799  PMCID:PMC5698488
  • Martins, M. A., Shin, Y. C., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Castro, I., Magnani, D. M., Ricciardi, M., Pedreno-Lopez, N., Bailey, V., Betancourt, D., et al. Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques PLoS Pathogens  2017 13  DOI:10.1371/journal.ppat.1006529  PMID:28732035  PMCID:PMC5540612
  • Pauthner, M., Havenar-Daughton, C., Sok, D., Nkolola, J. P., Bastidas, R., Boopathy, A. V., Carnathan, D. G., Chandrashekar, A., Cirelli, K. M., Cottrell, C. A., Eroshkin, A. M., Guenaga, J., et al. Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches Immunity  2017 46:1073-1088  DOI:10.1016/j.immuni.2017.05.007  PMID:28636956  PMCID:PMC5483234
  • Lee, J. H., Andrabi, R., Su, C. Y., Yasmeen, A., Julien, J. P., Kong, L., Wu, N. C., McBride, R., Sok, D., Pauthner, M., Cottrell, C. A., Nieusma, T., et al. A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure Immunity  2017 46:690-702  DOI:10.1016/j.immuni.2017.03.017  PMID:28423342  PMCID:PMC5400778
  • Cao, L., Diedrich, J. K., Kulp, D. W., Pauthner, M., He, L., Park, S. K. R., Sok, D., Su, C. Y., Delahunty, C. M., Menis, S., Andrabi, R., Guenaga, J., et al. Global site-specific N-glycosylation analysis of HIV envelope glycoprotein Nature Communications  2017 8  DOI:10.1038/ncomms14954  PMID:28348411
  • Havenar-Daughton, C., Carnathan, D. G., Torrents de la Peña, A., Pauthner, M., Briney, B., Reiss, S. M., Wood, J. S., Kaushik, K., van Gils, M. J., Rosales, S. L., van der Woude, P., Locci, M., et al. Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer Cell Reports  2016 17:2195-2209  DOI:10.1016/j.celrep.2016.10.085  PMID:27880897  PMCID:PMC5142765
  • Sok, D., Briney, B., Jardine, J. G., Kulp, D. W., Menis, S., Pauthner, M., Wood, A., Lee, E. C., Le, K. M., Jones, M., Ramos, A., Kalyuzhniy, O., et al. Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice Science  2016 353:1557-1560  DOI:10.1126/science.aah3945  PMID:27608668  PMCID:PMC5404394
  • McCoy, L. E., van Gils, M. J., Ozorowski, G., Messmer, T., Briney, B., Voss, J. E., Kulp, D. W., Macauley, M. S., Sok, D., Pauthner, M., Menis, S., Cottrell, C. A., et al. Holes in the glycan shield of the native HIV Envelope are a target of trimer-elicited neutralizing antibodies Cell Reports  2016 16:2327-2338  DOI:10.1016/j.celrep.2016.07.074  PMID:27545891  PMCID:PMC5007210
  • Jardine, J. G., Sok, D., Julien, J. P., Briney, B., Sarkar, A., Liang, C. H., Scherer, E. A., Henry Dunand, C. J., Adachi, Y., Diwanji, D., Hsueh, J., Jones, M., et al. Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design PLoS Pathogens  2016 12  DOI:10.1371/journal.ppat.1005815  PMID:27560183  PMCID:PMC4999182
  • Sok, D., Pauthner, M., Briney, B., Lee, J. H., Saye-Francisco, K. L., Hsueh, J., Ramos, A., Le, K. M., Jones, M., Jardine, J. G., Bastidas, R., Sarkar, A., et al. A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans Immunity  2016 45:31-45  DOI:10.1016/j.immuni.2016.06.026  PMID:27438765  PMCID:PMC4990068
  • Pauthner, M., Yeung, J., Ullman, C., Bakker, J., Wurch, T., Reichert, J. M., Lund-Johansen, F., Bradbury, A. R. M., Carter, P. J., Melis, J. P. M. Antibody engineering & therapeutics, the annual meeting of the antibody society December 7-10, 2015, San Diego, CA, USA MAbs  2016 8:617-652  DOI:10.1080/19420862.2016.1153211  PMID:26909869  PMCID:PMC4966842
  • van Gils, M. J., van den Kerkhof, T. L., Ozorowski, G., Cottrell, C. A., Sok, D., Pauthner, M., Pallesen, J., de Val, N., Yasmeen, A., de Taeye, S. W., Schorcht, A., Gumbs, S., et al. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability Nature Microbiology  2016 2  DOI:10.1038/nmicrobiol.2016.199  PMID:27841852  PMCID:PMC5372380
  • Jardine, J. G., Ota, T., Sok, D., Pauthner, M., Kulp, D. W., Kalyuzhniy, O., Skog, P. D., Thinnes, T. C., Bhullar, D., Briney, B., Menis, S., Jones, M., et al. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen Science  2015 349:156-161  DOI:10.1126/science.aac5894  PMID:26089355  PMCID:PMC4669217
  • Asmal, M., Luedemann, C., Lavine, C. L., Mach, L. V., Balachandran, H., Brinkley, C., Denny, T. N., Lewis, M. G., Anderson, H., Pal, R., Sok, D., Le, K., et al. Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes Virology  2015 475:37-45  DOI:10.1016/j.virol.2014.10.032  PMID:25462344  PMCID:PMC4280322
  • Sok, D., van Gils, M. J., Pauthner, M., Julien, J. P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex Proceedings of the National Academy of Sciences of the United States of America  2014 111:17624-17629  DOI:10.1073/pnas.1415789111  PMID:25422458  PMCID:PMC4267403
  • Almagro, J. C., Gilliland, G. L., Breden, F., Scott, J. K., Sok, D., Pauthner, M., Reichert, J. M., Helguera, G., Andrabi, R., Mabry, R., Blery, M., Voss, J. E., et al. Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CA MAbs  2014 6:577-618  DOI:10.4161/mabs.28421  PMID:24589717  PMCID:PMC4011904
  • Frenzel, E., Doll, V., Pauthner, M., Lucking, G., Scherer, S., Ehling-Schulz, M. CodY orchestrates the expression of virulence determinants in emetic Bacillus cereus by impacting key regulatory circuits Molecular Microbiology  2012 85:67-88  DOI:10.1111/j.1365-2958.2012.08090.x  PMID:22571587

• chapter

  • Pauthner, M. G., Hangartner, L. Broadly Neutralizing Antibodies to Highly Antigenically Variable Viruses as Templates for Vaccine Design Vaccination Strategies against Highly Variable Pathogens. 31-87. 2020  DOI:10.1007/82_2020_221

Background

education and training

• Ph.D. in Immunology, Scripps Research 2012 - 2017
• University of Erlangen-Nuremberg , Immunology 2010 - 2012
• M.S. in Cell/Cellular and Molecular Biology, Georgia Institute of Technology 2009 - 2010
• B.Sc. in Biochemistry, Biophysics and Molecular Biology, Technical University of Munich 2006 - 2009

advisee of

• graduate advising relationship

  • Burton, Dennis, Ph.D.  candidacy, 2013 - 2017

• postdoc or fellow advising relationship

  • Andersen, Kristian G., Ph.D.  candidacy, 2017 -

Contact

full name

• Matthias Georg Pauthner

geographic location

• Scripps California 

Additional Document Info

start page

• 1557

end page

• 1560

volume

• 353

issue

• 6307