recent publications
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academic article
- Carnathan, D. G., Kaushik, K., Ellebedy, A. H., Enemuo, C. A., Gebru, E. H., Dhadvai, P., Rasheed, M. A. U., Pauthner, M. G., Ozorowski, G., Ahmed, R., Burton, D. R., Ward, A. B., et al. Harnessing Activin A Adjuvanticity to Promote Antibody Responses to BG505 HIV Envelope Trimers Frontiers in Immunology 2020 11 DOI:10.3389/fimmu.2020.01213 PMID:32612608 PMCID:PMC7308430
- Nogal, B., McCoy, L. E., van Gils, M. J., Cottrell, C. A., Voss, J. E., Andrabi, R., Pauthner, M., Liang, C. H., Messmer, T., Nedellec, R., Shin, M., Turner, H. L., et al. HIV envelope trimer-elicited autologous neutralizing antibodies bind a region overlapping the N332 glycan supersite Science Advances 2020 6 DOI:10.1126/sciadv.aba0512 PMID:32548265 PMCID:PMC7274786
- Yang, Y. H. R., McCoy, L. E., van Gils, M. J., Andrabi, R., Turner, H. L., Yuan, M., Cottrell, C. A., Ozorowski, G., Voss, J., Pauthner, M., Polveroni, T. M., Messmer, T., et al. Autologous antibody responses to an HIV envelope glycan hole are not easily broadened in rabbits Journal of Virology 2020 94 DOI:10.1128/jvi.01861-19 PMID:31941772 PMCID:PMC7081899
- Pedreno-Lopez, N., Dang, C. M., Rosen, B. C., Ricciardi, M. J., Bailey, V. K., Gutman, M. J., Gonzalez-Nieto, L., Pauthner, M. G., Le, K., Song, G., Andrabi, R., Weisgrau, K. L., et al. Induction of transient virus replication facilitates antigen-independent isolation of SIV-specific monoclonal antibodies Molecular Therapy-Methods & Clinical Development 2020 16:225-237 DOI:10.1016/j.omtm.2020.01.010 PMID:32083148 PMCID:PMC7021589
- Zhao, F., Joyce, C., Burns, A., Nogal, B., Cottrell, C. A., Ramos, A., Biddle, T., Pauthner, M., Nedellec, R., Qureshi, H., Mason, R., Landais, E., et al. Mapping Neutralizing Antibody Epitope Specificities to an HIV Env Trimer in Immunized and in Infected Rhesus Macaques Cell Reports 2020 32 DOI:10.1016/j.celrep.2020.108122 PMID:32905766 PMCID:PMC7487785
- Pegu, A., Borate, B., Huang, Y., Pauthner, M. G., Hessell, A. J., Julg, B., Doria-Rose, N. A., Schmidt, S. D., Carpp, L. N., Cully, M. D., Chen, X., Shaw, G. M., et al. A meta-analysis of passive immunization studies shows that serum-neutralizing antibody titer associates with protection against SHIV challenge Cell Host & Microbe 2019 26:336-346 DOI:10.1016/j.chom.2019.08.014 PMID:31513771 PMCID:PMC6755677
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Andrabi, R., Pallesen, J., Allen, J. D., Song, G., Zhang, J., de Val, N., Gegg, G., Porter, K., Su, C., Pauthner, M., Newman, A., Bouton-Verville, H., et al. The chimpanzee SIV envelope trimer: structure and deployment as an HIV vaccine template Cell Reports 2019 27:2426-2441 DOI:10.1016/j.celrep.2019.04.082 PMID:31116986 PMCID:PMC6533203
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Cirelli, K. M., Carnathan, D. G., Nogal, B., Martin, J. T., Rodriguez, O. L., Upadhyay, A. A., Enemuo, C. A., Gebru, E. H., Choe, Y., Viviano, F., Nakao, C., Pauthner, M. G., et al. Slow delivery immunization enhances HIV neutralizing antibody and germinal center responses via modulation of immunodominance Cell 2019 177:1153-1171 DOI:10.1016/j.cell.2019.04.012 PMID:31080066
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Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers Immunity 2019 50:241-252 DOI:10.1016/j.immuni.2018.11.011 PMID:30552025 PMCID:PMC6335502
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Cao, L. W., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J. K., Menis, S., Sok, D., Bastidas, R., Park, S. K. R., Delahunty, C. M., He, L., et al. Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer Nature Communications 2018 9 DOI:10.1038/s41467-018-06121-4 PMID:30209313 PMCID:PMC6135743
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Bianchi, M., Turner, H. L., Nogal, B., Cottrell, C. A., Oyen, D., Pauthner, M., Bastidas, R., Nedellec, R., McCoy, L. E., Wilson, I. A., Burton, D. R., Ward, A. B., et al. Electron-microscopy-based epitope mapping defines specificities of polyclonal antibodies elicited during HIV-1 BG505 envelope trimer immunization Immunity 2018 49:288-300 DOI:10.1016/j.immuni.2018.07.009 PMID:30097292 PMCID:PMC6104742
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Martins, M. A., Tully, D. C., Pedreno-Lopez, N., von Bredow, B., Pauthner, M. G., Shin, Y. C., Yuan, M. L., Lima, N. S., Bean, D. J., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., et al. Mamu-B*17(+) rhesus macaques vaccinated with env, vif, and nef manifest early control of SIVmac239 replication Journal of Virology 2018 92:e00690-18 DOI:10.1128/jvi.00690-18 PMID:29875239 PMCID:PMC6069176
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Cao, L., Diedrich, J. K., Ma, Y., Wang, N., Pauthner, M., Park, S. K. R., Delahunty, C. M., McLellan, J. S., Burton, D. R., Yates III, J. R., Paulson, J. C. Global site-specific analysis of glycoprotein N-glycan processing Nature Protocols 2018 13:1196-1212 DOI:10.1038/nprot.2018.024 PMID:29725121 PMCID:PMC5941933
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Kulp, D. W., Steichen, J. M., Pauthner, M., Hu, X., Schiffner, T., Liguori, A., Cottrell, C. A., Havenar-Daughton, C., Ozorowski, G., Georgeson, E., Kalyuzhniy, O., Willis, J. R., et al. Structure-based design of native-like HIV-1 envelope trimers to silence non-neutralizing epitopes and eliminate CD4 binding Nature Communications 2017 8 DOI:10.1038/s41467-017-01549-6 PMID:29162799 PMCID:PMC5698488
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Martins, M. A., Shin, Y. C., Gonzalez-Nieto, L., Domingues, A., Gutman, M. J., Maxwell, H. S., Castro, I., Magnani, D. M., Ricciardi, M., Pedreno-Lopez, N., Bailey, V., Betancourt, D., et al. Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques PLoS Pathogens 2017 13 DOI:10.1371/journal.ppat.1006529 PMID:28732035 PMCID:PMC5540612
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Pauthner, M., Havenar-Daughton, C., Sok, D., Nkolola, J. P., Bastidas, R., Boopathy, A. V., Carnathan, D. G., Chandrashekar, A., Cirelli, K. M., Cottrell, C. A., Eroshkin, A. M., Guenaga, J., et al. Elicitation of robust tier 2 neutralizing antibody responses in nonhuman primates by HIV envelope trimer immunization using optimized approaches Immunity 2017 46:1073-1088 DOI:10.1016/j.immuni.2017.05.007 PMID:28636956 PMCID:PMC5483234
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Lee, J. H., Andrabi, R., Su, C. Y., Yasmeen, A., Julien, J. P., Kong, L., Wu, N. C., McBride, R., Sok, D., Pauthner, M., Cottrell, C. A., Nieusma, T., et al. A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure Immunity 2017 46:690-702 DOI:10.1016/j.immuni.2017.03.017 PMID:28423342 PMCID:PMC5400778
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Cao, L., Diedrich, J. K., Kulp, D. W., Pauthner, M., He, L., Park, S. K. R., Sok, D., Su, C. Y., Delahunty, C. M., Menis, S., Andrabi, R., Guenaga, J., et al. Global site-specific N-glycosylation analysis of HIV envelope glycoprotein Nature Communications 2017 8 DOI:10.1038/ncomms14954 PMID:28348411
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Havenar-Daughton, C., Carnathan, D. G., Torrents de la Peña, A., Pauthner, M., Briney, B., Reiss, S. M., Wood, J. S., Kaushik, K., van Gils, M. J., Rosales, S. L., van der Woude, P., Locci, M., et al. Direct probing of germinal center responses reveals immunological features and bottlenecks for neutralizing antibody responses to HIV Env trimer Cell Reports 2016 17:2195-2209 DOI:10.1016/j.celrep.2016.10.085 PMID:27880897 PMCID:PMC5142765
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Sok, D., Briney, B., Jardine, J. G., Kulp, D. W., Menis, S., Pauthner, M., Wood, A., Lee, E. C., Le, K. M., Jones, M., Ramos, A., Kalyuzhniy, O., et al. Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice Science 2016 353:1557-1560 DOI:10.1126/science.aah3945 PMID:27608668 PMCID:PMC5404394
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McCoy, L. E., van Gils, M. J., Ozorowski, G., Messmer, T., Briney, B., Voss, J. E., Kulp, D. W., Macauley, M. S., Sok, D., Pauthner, M., Menis, S., Cottrell, C. A., et al. Holes in the glycan shield of the native HIV Envelope are a target of trimer-elicited neutralizing antibodies Cell Reports 2016 16:2327-2338 DOI:10.1016/j.celrep.2016.07.074 PMID:27545891 PMCID:PMC5007210
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Jardine, J. G., Sok, D., Julien, J. P., Briney, B., Sarkar, A., Liang, C. H., Scherer, E. A., Henry Dunand, C. J., Adachi, Y., Diwanji, D., Hsueh, J., Jones, M., et al. Minimally mutated HIV-1 broadly neutralizing antibodies to guide reductionist vaccine design PLoS Pathogens 2016 12 DOI:10.1371/journal.ppat.1005815 PMID:27560183 PMCID:PMC4999182
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Sok, D., Pauthner, M., Briney, B., Lee, J. H., Saye-Francisco, K. L., Hsueh, J., Ramos, A., Le, K. M., Jones, M., Jardine, J. G., Bastidas, R., Sarkar, A., et al. A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans Immunity 2016 45:31-45 DOI:10.1016/j.immuni.2016.06.026 PMID:27438765 PMCID:PMC4990068
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Pauthner, M., Yeung, J., Ullman, C., Bakker, J., Wurch, T., Reichert, J. M., Lund-Johansen, F., Bradbury, A. R. M., Carter, P. J., Melis, J. P. M. Antibody engineering & therapeutics, the annual meeting of the antibody society December 7-10, 2015, San Diego, CA, USA MAbs 2016 8:617-652 DOI:10.1080/19420862.2016.1153211 PMID:26909869 PMCID:PMC4966842
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van Gils, M. J., van den Kerkhof, T. L., Ozorowski, G., Cottrell, C. A., Sok, D., Pauthner, M., Pallesen, J., de Val, N., Yasmeen, A., de Taeye, S. W., Schorcht, A., Gumbs, S., et al. An HIV-1 antibody from an elite neutralizer implicates the fusion peptide as a site of vulnerability Nature Microbiology 2016 2 DOI:10.1038/nmicrobiol.2016.199 PMID:27841852 PMCID:PMC5372380
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Jardine, J. G., Ota, T., Sok, D., Pauthner, M., Kulp, D. W., Kalyuzhniy, O., Skog, P. D., Thinnes, T. C., Bhullar, D., Briney, B., Menis, S., Jones, M., et al. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen Science 2015 349:156-161 DOI:10.1126/science.aac5894 PMID:26089355 PMCID:PMC4669217
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Asmal, M., Luedemann, C., Lavine, C. L., Mach, L. V., Balachandran, H., Brinkley, C., Denny, T. N., Lewis, M. G., Anderson, H., Pal, R., Sok, D., Le, K., et al. Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes Virology 2015 475:37-45 DOI:10.1016/j.virol.2014.10.032 PMID:25462344 PMCID:PMC4280322
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Sok, D., van Gils, M. J., Pauthner, M., Julien, J. P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex Proceedings of the National Academy of Sciences of the United States of America 2014 111:17624-17629 DOI:10.1073/pnas.1415789111 PMID:25422458 PMCID:PMC4267403
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Almagro, J. C., Gilliland, G. L., Breden, F., Scott, J. K., Sok, D., Pauthner, M., Reichert, J. M., Helguera, G., Andrabi, R., Mabry, R., Blery, M., Voss, J. E., et al. Antibody engineering and therapeutics, The Annual Meeting of the Antibody Society: December 8-12, 2013, Huntington Beach, CA MAbs 2014 6:577-618 DOI:10.4161/mabs.28421 PMID:24589717 PMCID:PMC4011904
- Frenzel, E., Doll, V., Pauthner, M., Lucking, G., Scherer, S., Ehling-Schulz, M. CodY orchestrates the expression of virulence determinants in emetic Bacillus cereus by impacting key regulatory circuits Molecular Microbiology 2012 85:67-88 DOI:10.1111/j.1365-2958.2012.08090.x PMID:22571587