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Paulson, James
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Paulson, James

Faculty Member
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Positions

  • 2017 - Professor (Joint Appointment), Immunology and Microbiology , Scripps Research
  • 2017 - Co-Chair, Molecular Medicine , Scripps Research
  • 2017 - Professor, Molecular Medicine , Scripps Research
  • 1999 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2013 - 2017 Chairman, Cell and Molecular Biology (CMB) , Scripps Research
  • 2007 - 2017 Professor (Joint Appointment), Chemical Physiology , Scripps Research
  • 1999 - 2017 Professor (Joint Appointment), Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2014 - 2015 Acting President & CEO, Scripps Research
  • 1999 - 2012 Professor (Joint Appointment), Molecular Biology , Scripps Research
  • 1996 - 1999 Vice President, Chief Scientific Officer, General Manager (Glytec Division), Member of Board of Directors, Cytel Corporation
  • 1990 - 1996 Vice President of Research & Development, Member of Board of Directors, Cytel Corporation
  • 1985 - 1990 Professor and Vice-Chair, Department of Biological Chemistry, School of Medicine, University of California, Los Angeles
  • 1981 - 1985 Associate Professor, Department of Biological Chemistry, School of Medicine, University of California, Los Angeles
  • 1978 - 1981 Assistant Professor, Department of Biological Chemistry, University of California, Los Angeles
  • 1974 - 1978 Postdoctoral Fellow / Research Associate, Department of Biochemistry, Duke University
Dr. James Paulson studies carbohydrate recognition and the molecular biology of carbohydrate binding proteins, like CD22, which mediate key aspects of cell signaling in the immune system.

Research Areas research areas

  • Cancer (UMLS)

Contact

  • jpaulson@scripps.edu

Websites

  • Faculty Member page: James C. Paulson, Ph.D.
  • Paulson Laboratory
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Publications

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    • Weiss, M., Ott, D., Karagiannis, T., Weishaupt, M., Niemietz, M., Eller, S., Lott, M., Martinez-Orts, M., Canales, A., Razi, N., Paulson, J., Unverzagt, C. Efficient Chemoenzymatic Synthesis of N-Glycans with a β1,4-Galactosylated Bisecting GlcNAc Motif Chembiochem  2020  DOI:10.1002/cbic.202000268  PMID:32597008
    • Lee, S., Yang, Y. A., Milano, S. K., Nguyen, T., Ahn, C., Sim, J. H., Thompson, A. J., Hillpot, E. C., Yoo, G., Paulson, J. C., Song, J. Salmonella Typhoid Toxin PltB Subunit and Its Non-typhoidal Salmonella Ortholog Confer Differential Host Adaptation and Virulence Cell Host & Microbe  2020 27:937-946  DOI:10.1016/j.chom.2020.04.005  PMID:32396840  PMCID:PMC7292776
    • Eggink, D., Spronken, M., van der Woude, R., Buzink, J., Broszeit, F., McBride, R., Pawestri, H. A., Setiawaty, V., Paulson, J. C., Boons, G. J., Fouchier, R. A. M., Russell, C. A., et al. Phenotypic Effects of Substitutions within the Receptor Binding Site of Highly Pathogenic Avian Influenza H5N1 Virus Observed during Human Infection Journal of Virology  2020 94  DOI:10.1128/jvi.00195-20  PMID:32321815  PMCID:PMC7307160
    • Thompson, A. J., Cao, L., Ma, Y., Wang, X., Diedrich, J. K., Kikuchi, C., Willis, S., Worth, C., McBride, R., Yates III, J. R., Paulson, J. C. Human Influenza Virus Hemagglutinins Contain Conserved Oligomannose N-Linked Glycans Allowing Potent Neutralization by Lectins Cell Host & Microbe  2020 27:725-735  DOI:10.1016/j.chom.2020.03.009  PMID:32298658  PMCID:PMC7158820
    • Herfst, S., Zhang, J., Richard, M., McBride, R., Lexmond, P., Bestebroer, T. M., Spronken, M. I. J., de Meulder, D., van den Brand, J. M., Rosu, M. E., Martin, S. R., Gamblin, S. J., et al. Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals Cell Host & Microbe  2020 28:602-613  DOI:10.1016/j.chom.2020.08.011  PMID:33031770  PMCID:PMC7556738
    • Duan, S., Paulson, J. C. Siglecs as Immune Cell Checkpoints in Disease Annual Review of Immunology  2020 38:365-395  DOI:10.1146/annurev-immunol-102419-035900  PMID:31986070
    • Zhu, X., Turner, H. L., Lang, S., McBride, R., Bangaru, S., Gilchuk, I. M., Yu, W., Paulson, J. C., Crowe, J. E., Ward, A. B., Wilson, I. A. Structural basis of protection against H7N9 influenza virus by human anti-N9 neuraminidase antibodies Cell Host & Microbe  2019 26:729-738  DOI:10.1016/j.chom.2019.10.002  PMID:31757767  PMCID:PMC6908751
    • Bhattacherjee, A., Rodrigues, E., Jung, J., Luzentales-Simpson, M., Enterina, J. R., Galleguillos, D., St Laurent, C. D., Nakhaei-Nejad, M., Fuchsberger, F. F., Streith, L., Wang, Q., Kawasaki, N., et al. Repression of phagocytosis by human CD33 is not conserved with mouse CD33 Communications Biology  2019 2  DOI:10.1038/s42003-019-0698-6  PMID:31815204  PMCID:PMC6890642
    • Nycholat, C. M., Duan, S., Knuplez, E., Worth, C., Elich, M., Yao, A., O'Sullivan, J., McBride, R., Wei, Y., Fernandes, S. M., Zhu, Z., Schnaar, R. L., et al. A sulfonamide sialoside analogue for targeting siglec-8 and -F on immune cells Journal of the American Chemical Society  2019 141:14032-14037  DOI:10.1021/jacs.9b05769  PMID:31460762
    • Neelamegham, S., Aoki-Kinoshita, K., Bolton, E., Frank, M., Lisacek, F., Lutteke, T., O'Boyle, N., Packer, N. H., Stanley, P., Toukach, P., Varki, A., Woods, R. J., et al. Updates to the Symbol Nomenclature for Glycans guidelines Glycobiology  2019 29:620-624  DOI:10.1093/glycob/cwz045  PMID:31184695
    • Narimatsu, Y., Joshi, H. J., Nason, R., Van Coillie, J., Karlsson, R., Sun, L., Ye, Z., Chen, Y. H., Schjoldager, K. T., Steentoft, C., Furukawa, S., Bensing, B. A., et al. An atlas of human glycosylation pathways enables display of the human glycome by gene engineered cells Molecular Cell  2019 75:394-407  DOI:10.1016/j.molcel.2019.05.017  PMID:31227230  PMCID:PMC6660356
    • Wu, N. C., Lv, H., Thompson, A. J., Wu, D. C., Ng, W. W. S., Kadam, R. U., Lin, C. W., Nycholat, C. M., McBride, R., Liang, W., Paulson, J. C., Mok, C. K. P., et al. Preventing an antigenically disruptive mutation in egg-based H3N2 seasonal influenza vaccines by mutational incompatibility Cell Host & Microbe  2019 25:836-844  DOI:10.1016/j.chom.2019.04.013  PMID:31151913
    • Bednar, K. J., Nycholat, C. M., Rao, T. S., Paulson, J. C., Fung-Leung, W. P., Macauley, M. S. Exploiting CD22 to selectively tolerize autoantibody producing B-cells in rheumatoid arthritis ACS Chemical Biology  2019 14:644-654  DOI:10.1021/acschembio.8b01018  PMID:30835424
    • Duan, S., Koziol-White, C. J., Jester Jr., W. F., Nycholat, C. M., Macauley, M. S., Panettieri Jr., R. A., Paulson, J. C. CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen Journal of Clinical Investigation  2019 129:1387-1401  DOI:10.1172/jci125456  PMID:30645205  PMCID:PMC6391081
    • Obadan, A. O., Santos, J., Ferreri, L., Thompson, A. J., Carnaccini, S., Geiger, G., Reiche, A. S. G., Rajao, D. S., Paulson, J. C., Perez, D. R. Flexibility in vitro of amino acid 226 in the receptor-binding site of an H9 subtype influenza A virus and its effect in vivo on virus replication, tropism, and transmission Journal of Virology  2019 93:e02011-18  DOI:10.1128/jvi.02011-18  PMID:30567980  PMCID:PMC6401463
    • Thompson, A. J., de Vries, R. P., Paulson, J. C. Virus recognition of glycan receptors Current Opinion in Virology  2019 34:117-129  DOI:10.1016/j.coviro.2019.01.004  PMID:30849709  PMCID:PMC6476673
    • Santos, J. J. S., Abente, E. J., Obadan, A. O., Thompson, A. J., Ferreri, L., Geiger, G., Gonzalez-Reiche, A. S., Lewis, N. S., Burke, D. F., Rajao, D. S., Paulson, J. C., Vincent, A. L., et al. Plasticity of amino acid residue 145 near the receptor binding site of H3 swine influenza A viruses and Its impact on receptor binding and antibody recognition Journal of Virology  2019 93:e01413-18  DOI:10.1128/jvi.01413-18  PMID:30355680  PMCID:PMC6321904
    • de Toro, B. F., Peng, W. J., Thompson, A. J., Dominguez, G., Canada, F. J., Perez-Castells, J., Paulson, J. C., Jimenez-Barbero, J., Canales, A. Avenues to characterize the interactions of extended N-glycans with proteins by NMR spectroscopy: the influenza hemagglutinin case Angewandte Chemie-International Edition  2018 57:15051-15055  DOI:10.1002/anie.201807162  PMID:30238596  PMCID:PMC6282704
    • Gao, Z., Thompson, A. J., Paulson, J. C., Withers, S. G. Proximity Ligation-Based Fluorogenic Imaging Agents for Neuraminidases Angewandte Chemie-International Edition  2018 57:13538-13541  DOI:10.1002/anie.201808196  PMID:30216626
    • Gonzalez-Gil, A., Porell, R. N., Fernandes, S. M., Wei, Y. D., Yu, H. F., Carroll, D. J., McBride, R., Paulson, J. C., Tiemeyer, M., Aoki, K., Bochner, B. S., Schnaar, R. L. Sialylated keratan sulfate proteoglycans are Siglec-8 ligands in human airways Glycobiology  2018 28:786-801  DOI:10.1093/glycob/cwy057  PMID:29924315  PMCID:PMC6142871
    • Cao, L. W., Pauthner, M., Andrabi, R., Rantalainen, K., Berndsen, Z., Diedrich, J. K., Menis, S., Sok, D., Bastidas, R., Park, S. K. R., Delahunty, C. M., He, L., et al. Differential processing of HIV envelope glycans on the virus and soluble recombinant trimer Nature Communications  2018 9  DOI:10.1038/s41467-018-06121-4  PMID:30209313  PMCID:PMC6135743
    • Guo, H., Rabouw, H., Slomp, A., Dai, M., van der Vegt, F., van Lent, J. W. M., McBride, R., Paulson, J. C., de Groot, R. J., van Kuppeveld, F. J. M., de Vries, E., de Haan, C. A. M. Kinetic analysis of the influenza A virus HA/NA balance reveals contribution of NA to virus-receptor binding and NA-dependent rolling on receptor-containing surfaces PLoS Pathogens  2018 14  DOI:10.1371/journal.ppat.1007233  PMID:30102740  PMCID:PMC6107293
    • Havenar-Daughton, C., Sarkar, A., Kulp, D. W., Toy, L., Hu, X., Deresa, I., Kalyuzhniy, O., Kaushik, K., Upadhyay, A. A., Menis, S., Landais, E., Cao, L., et al. The human naive B cell repertoire contains distinct subclasses for a germline-targeting HIV-1 vaccine immunogen Science Translational Medicine  2018 10  DOI:10.1126/scitranslmed.aat0381  PMID:29973404
    • Imai, H., Dinis, J. M., Zhong, G., Moncla, L. H., Lopes, T. J. S., McBride, R., Thompson, A. J., Peng, W., Le, M. T. Q., Hanson, A., Lauck, M., Sakai-Tagawa, Y., et al. Diversity of influenza A(H5N1) viruses in infected humans, Northern Vietnam, 2004-2010 Emerging Infectious Diseases  2018 24:1228-1238  DOI:10.3201/eid2407.171441  PMID:29912683
    • Rantalainen, K., Berndsen, Z. T., Murrell, S., Cao, L., Omorodion, O., Torres, J. L., Wu, M., Umotoy, J., Copps, J., Poignard, P., Landais, E., Paulson, J. C., et al. Co-evolution of HIV envelope and apex-targeting neutralizing antibody lineage provides benchmarks for vaccine design Cell Reports  2018 23:3249-3261  DOI:10.1016/j.celrep.2018.05.046  PMID:29898396  PMCID:PMC6019700
    • Cao, L., Diedrich, J. K., Ma, Y., Wang, N., Pauthner, M., Park, S. K. R., Delahunty, C. M., McLellan, J. S., Burton, D. R., Yates III, J. R., Paulson, J. C. Global site-specific analysis of glycoprotein N-glycan processing Nature Protocols  2018 13:1196-1212  DOI:10.1038/nprot.2018.024  PMID:29725121  PMCID:PMC5941933
    • Peng, W., Bouwman, K. M., McBride, R., Grant, O. C., Woods, R. J., Verheije, M. H., Paulson, J. C., de Vries, R. P. Enhanced human-type receptor binding by ferret-transmissible H5N1 with a K193T mutation Journal of Virology  2018 92:e02016-17  DOI:10.1128/jvi.02016-17  PMID:29491160  PMCID:PMC5923085
    • Wu, N. C., Thompson, A. J., Xie, J., Lin, C. W., Nycholat, C. M., Zhu, X., Lerner, R. A., Paulson, J. C., Wilson, I. A. A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site Nature Communications  2018 9  DOI:10.1038/s41467-018-03663-5  PMID:29593268  PMCID:PMC5871881
    • Sun, Y., Hong, S., Xie, R., Huang, R., Lei, R., Cheng, B., Sun, D. E., Du, Y., Nycholat, C. M., Paulson, J. C., Chen, X. Mechanistic investigation and multiplexing of liposome-assisted metabolic glycan labeling Journal of the American Chemical Society  2018 140:3592-3602  DOI:10.1021/jacs.7b10990  PMID:29446631
    • Yang, Y. A., Lee, S., Zhao, J., Thompson, A. J., McBride, R., Tsogtbaatar, B., Paulson, J. C., Nussinov, R., Deng, L., Song, J. In vivo tropism of Salmonella Typhi toxin to cells expressing a multiantennal glycan receptor Nature Microbiology  2018 3:155-163  DOI:10.1038/s41564-017-0076-4  PMID:29203881
    • Spiller, F., Nycholat, C. M., Kikuchi, C., Paulson, J. C., Macauley, M. S. Murine red blood cells lack ligands for B cell Siglecs, allowing strong activation by erythrocyte surface antigens Journal of Immunology  2018 200:949-956  DOI:10.4049/jimmunol.1701257  PMID:29288201  PMCID:PMC5780208
    • Han, K. H., Arlian, B. M., Macauley, M. S., Paulson, J. C., Lerner, R. A. Migration-based selections of antibodies that convert bone marrow into trafficking microglia-like cells that reduce brain amyloid β Proceedings of the National Academy of Sciences of the United States of America  2018 115:E372-E381  DOI:10.1073/pnas.1719259115  PMID:29295920  PMCID:PMC5777004
    • Hatta, M., Zhong, G., Gao, Y., Nakajima, N., Fan, S., Chiba, S., Deering, K. M., Ito, M., Imai, M., Kiso, M., Nakatsu, S., Lopes, T. J., et al. Characterization of a feline influenza A(H7N2) virus Emerging Infectious Diseases  2018 24:75-86  DOI:10.3201/eid2401.171240  PMID:29260686  PMCID:PMC5749472
    • Imai, M., Watanabe, T., Kiso, M., Nakajima, N., Yamayoshi, S., Iwatsuki-Horimoto, K., Hatta, M., Yamada, S., Ito, M., Sakai-Tagawa, Y., Shirakura, M., Takashita, E., et al. A highly pathogenic avian H7N9 influenza virus isolated from a human Is lethal in some ferrets infected via respiratory droplets Cell Host & Microbe  2017 22:615-626  DOI:10.1016/j.chom.2017.09.008  PMID:29056430
    • Taubenschmid, J., Stadlmann, J., Jost, M., Klokk, T. I., Rillahan, C. D., Leibbrandt, A., Mechtler, K., Paulson, J. C., Jude, J., Zuber, J., Sandvig, K., Elling, U., et al. A vital sugar code for ricin toxicity Cell Research  2017 27:1351-1364  DOI:10.1038/cr.2017.116  PMID:28925387  PMCID:PMC5674155
    • Bednar, K. J., Shanina, E., Ballet, R., Connors, E. P., Duan, S., Juan, J., Arlian, B. M., Kulis, M. D., Butcher, E. C., Fung-Leung, W. P., Rao, T. S., Paulson, J. C., et al. Human CD22 inhibits murine B cell receptor activation in a human CD22 transgenic mouse model Journal of Immunology  2017 199:3116-3128  DOI:10.4049/jimmunol.1700898  PMID:28972089  PMCID:PMC5679471
    • Li, W., Hulswit, R. J. G., Widjaja, I., Raj, V. S., McBride, R., Peng, W., Widagdo, W., Tortorici, M. A., van Dieren, B., Lang, Y., van Lent, J. W. M., Paulson, J. C., et al. Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein Proceedings of the National Academy of Sciences of the United States of America  2017 114:E8508-E8517  DOI:10.1073/pnas.1712592114  PMID:28923942  PMCID:PMC5635925
    • Wu, N. C., Zost, S. J., Thompson, A. J., Oyen, D., Nycholat, C. M., McBride, R., Paulson, J. C., Hensley, S. E., Wilson, I. A. A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine PLoS Pathogens  2017 13  DOI:10.1371/journal.ppat.1006682  PMID:29059230  PMCID:PMC5667890
    • Tiemeyer, M., Aoki, K., Paulson, J., Cummings, R. D., York, W. S., Karlsson, N. G., Lisacek, F., Packer, N. H., Campbell, M. P., Aoki, N. P., Fujita, A., Matsubara, M., et al. GlyTouCan: an accessible glycan structure repository Glycobiology  2017 27:915-919  DOI:10.1093/glycob/cwx066  PMID:28922742
    • Peng, W. J., Paulson, J. C. CD22 ligands on a natural N-glycan scaffold efficiently deliver toxins to B-lymphoma cells Journal of the American Chemical Society  2017 139:12450-12458  DOI:10.1021/jacs.7b03208  PMID:28829594
    • de Vries, R. P., Tzarum, N., Peng, W., Thompson, A. J., Wickramasinghe, I. N. A., de la Pena, A. T. T., van Breemen, M. J., Bouwman, K. M., Zhu, X., McBride, R., Yu, W., Sanders, R. W., et al. A single mutation in Taiwanese H6N1 influenza hemagglutinin switches binding to human-type receptors EMBO Molecular Medicine  2017 9:1314-1325  DOI:10.15252/emmm.201707726  PMID:28694323  PMCID:PMC5582370
    • Pang, L., Macauley, M. S., Arlian, B. M., Nycholat, C. M., Paulson, J. C. Encapsulating an immunosuppressant enhances tolerance induction by Siglec-engaging tolerogenic liposomes ChemBioChem  2017 18:1226-1233  DOI:10.1002/cbic.201600702  PMID:28231415  PMCID:PMC5496789
    • de Vries, R. P., Peng, W., Grant, O. C., Thompson, A. J., Zhu, X., Bouwman, K. M., de la Pena, A. T. T., van Breemen, M. J., Wickramasinghe, I. N. A., de Haan, C. A. M., Yu, W., McBride, R., et al. Three mutations switch H7N9 influenza to human-type receptor specificity PLoS Pathogens  2017 13  DOI:10.1371/journal.ppat.1006390  PMID:28617868  PMCID:PMC5472306
    • Tzarum, N., McBride, R., Nycholat, C. M., Peng, W., Paulson, J. C., Wilson, I. A. Unique structural features of influenza virus H15 hemagglutinin Journal of Virology  2017 91:e00046-17  DOI:10.1128/jvi.00046-17  PMID:28404848
    • Dai, M., McBride, R., Dortmans, J.C., Peng, W., Bakkers, M. J., de Groot, R. J., van Kuppeveld, F. J., Paulson, J. C., de Vries, E., de Haan, C. A. Mutation of the second sialic acid-binding site, resulting in reduced neuraminidase activity, preceded the emergence of H7N9 influenza A virus Journal of Virology  2017 91:e00049-17  DOI:10.1128/jvi.00049-17  PMID:28202753  PMCID:PMC5391454
    • Lee, J. H., Andrabi, R., Su, C. Y., Yasmeen, A., Julien, J. P., Kong, L., Wu, N. C., McBride, R., Sok, D., Pauthner, M., Cottrell, C. A., Nieusma, T., et al. A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure Immunity  2017 46:690-702  DOI:10.1016/j.immuni.2017.03.017  PMID:28423342  PMCID:PMC5400778
    • Tzarum, N., de Vries, R. P., Peng, W., Thompson, A. J., Bouwman, K. M., McBride, R., Yu, W., Zhu, X., Verheije, M. H., Paulson, J. C., Wilson, I. A. The 150-loop restricts the host specificity of human H10N8 influenza virus Cell Reports  2017 19:235-245  DOI:10.1016/j.celrep.2017.03.054  PMID:28402848  PMCID:PMC5452617
    • Polonskaya, Z., Deng, S., Sarkar, A., Kain, L., Comellas-Aragones, M., McKay, C. S., Kaczanowska, K., Holt, M., McBride, R., Palomo, V., Self, K. M., Taylor, S., et al. T cells control the generation of nanomolar-affinity anti-glycan antibodies Journal of Clinical Investigation  2017 127:1491-1504  DOI:10.1172/jci91192  PMID:28287405  PMCID:PMC5373877
    • Liu, Y., McBride, R., Stoll, M., Palma, A. S., Silva, L., Agravat, S., Aoki-Kinoshita, K. F., Campbell, M. P., Costello, C. E., Dell, A., Haslam, S. M., Karlsson, N. G., et al. The minimum information required for a glycomics experiment (MIRAGE) project: Improving the standards for reporting glycan microarray-based data Glycobiology  2017 27:280-284  DOI:10.1093/glycob/cww118  PMID:27993942
    • Cao, L., Diedrich, J. K., Kulp, D. W., Pauthner, M., He, L., Park, S. K. R., Sok, D., Su, C. Y., Delahunty, C. M., Menis, S., Andrabi, R., Guenaga, J., et al. Global site-specific N-glycosylation analysis of HIV envelope glycoprotein Nature Communications  2017 8  DOI:10.1038/ncomms14954  PMID:28348411
    • Guo, H., de Vries, E., McBride, R., Dekkers, J., Peng, W., Bouwman, K. M., Nycholat, C., Verheije, M. H., Paulson, J. C., van Kuppeveld, F. J. M., de Haan, C. A. M. Highly pathogenic influenza A(H5Nx) viruses with altered H5 receptor-binding specificity Emerging Infectious Diseases  2017 23:220-231  DOI:10.3201/eid2302.161072  PMID:27869615  PMCID:PMC5324792
    • Zanin, M., Kocer, Z. A., Poulson, R. L., Gabbard, J. D., Howerth, E. W., Jones, C. A., Friedman, K., Seiler, J., Danner, A., Kercher, L., McBride, R., Paulson, J. C., et al. Potential for low-pathogenic avian H7 influenza A viruses to replicate and cause disease in a mammalian model Journal of Virology  2017 91  DOI:10.1128/jvi.01934-16  PMID:27852855  PMCID:PMC5244340
    • Hanske, J., Schulze, J., Aretz, J., McBride, R., Loll, B., Schmidt, H., Knirel, Y., Rabsch, W., Wahl, M. C., Paulson, J. C., Rademacher, C. Bacterial polysaccharide specificity of the pattern recognition receptor langerin is highly species- dependent Journal of Biological Chemistry  2017 292:862-871  DOI:10.1074/jbc.M116.751750  PMID:27903635  PMCID:PMC5247659
    • Peng, W., de Vries, R. P., Grant, O. C., Thompson, A. J., McBride, R., Tsogtbaatar, B., Lee, P. S., Razi, N., Wilson, I. A., Woods, R. J., Paulson, J. C. Recent H3N2 viruses have evolved specificity for extended, branched human-type receptors, conferring potential for increased avidity Cell Host & Microbe  2017 21:23-34  DOI:10.1016/j.chom.2016.11.004  PMID:28017661  PMCID:PMC5233592
    • Wu, N. C., Xie, J., Zheng, T., Nycholat, C. M., Grande, G., Paulson, J. C., Lerner, R. A., Wilson, I. A. Diversity of functionally permissive sequences in the receptor-binding site of influenza hemagglutinin Cell Host & Microbe  2017 21:742-753  DOI:10.1016/j.chom.2017.05.011  PMID:28618270
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    • Blixt, O., Brown, J., Schur, M. J., Wakarchuk, W., Paulson, J. C. Efficient preparation of natural and synthetic galactosides with a recombinant beta-1,4-galactosyltransferase-/udp-4 '-gal epimerase fusion protein Journal of Organic Chemistry  2001 66:2442-2448  DOI:10.1021/jo0057809  PMID:11281786
    • Alexander, J., del Guercio, M. F., Maewal, A., Qiao, L., Fikes, J., Chesnut, R. W., Paulson, J., Bundle, D. R., DeFrees, S., Sette, A. Linear padre t helper epitope and carbohydrate b cell epitope conjugates induce specific high titer igg antibody responses Journal of Immunology  2000 164:1625-1633  PMID:10640784
    • Ito, T., Couceiro, Jnss, Kelm, S., Baum, L. G., Krauss, S., Castrucci, M. R., Donatelli, I., Kida, H., Paulson, J. C., Webster, R. G., Kawaoka, Y. Molecular basis for the generation in pigs of influenza a viruses with pandemic potential Journal of Virology  1998 72:7367-7373  PMID:9696833  PMCID:PMC109961
    • Talbott, G. A., Sharar, S. R., Paulson, J. C., Harlan, J. M., Winn, R. K. Antibiotic therapy determines subcutaneous escherichia coli abscess formation after cd18 inhibition in rabbits Journal of Burn Care & Rehabilitation  1998 19:284-291  DOI:10.1097/00004630-199807000-00003  PMID:9710724
    • Datta, A. K., Sinha, A., Paulson, J. C. Mutation of the sialyltransferase s-sialylmotif alters the kinetics of the donor and acceptor substrates Journal of Biological Chemistry  1998 273:9608-9614  DOI:10.1074/jbc.273.16.9608  PMID:9545292
    • Hennet, T., Chui, D., Paulson, J. C., Marth, J. D. Immune regulation by the st6gal sialyltransferase Proceedings of the National Academy of Sciences of the United States of America  1998 95:4504-4509  DOI:10.1073/pnas.95.8.4504  PMID:9539767
    • Datta, A. K., Paulson, J. C. Sialylmotifs of sialyltransferases Indian Journal of Biochemistry & Biophysics  1997 34:157-165  PMID:9343944
    • Tsuji, S., Datta, A. K., Paulson, J. C. Systematic nomenclature for sialyltransferases Glycobiology  1996 6:v-vii  PMID:8953271
    • Wakefield, T. W., Strieter, R. M., Downing, L. J., Kadell, A. M., Wilke, C. A., Burdick, M. D., Wrobleski, S. K., Phillips, M. L., Paulson, J. C., Anderson, D. C., Greenfield, L. J. P-selectin and tnf inhibition reduce venous thrombosis inflammation Journal of Surgical Research  1996 64:26-31  DOI:10.1006/jsre.1996.0301  PMID:8806469
    • Tojo, S. J., Yokota, S., Koike, H., Schultz, J., Hamazume, Y., Misugi, E., Yamada, K., Hayashi, M., Paulson, J. C., Morooka, S. Reduction of rat myocardial ischemia and reperfusion injury by sialyl lewis x oligosaccharide and anti-rat p-selectin antibodies Glycobiology  1996 6:463-469  DOI:10.1093/glycob/6.4.463  PMID:8842711
    • Sjoberg, E. R., Kitagawa, H., Glushka, J., vanHalbeek, H., Paulson, J. C. Molecular cloning of a developmentally regulated n-acetylgalactosamine alpha 2,6-sialyltransferase specific for sialylated glycoconjugates Journal of Biological Chemistry  1996 271:7450-7459  PMID:8631773
    • Kitagawa, H., Mattei, M. G., Paulson, J. C. Genomic organization and chromosomal mapping of the gal beta 1,3galnac/gal beta 1,4glcnac alpha 2,3-sialyltransferase Journal of Biological Chemistry  1996 271:931-938  PMID:8557707
    • Murohara, T., Margiotta, J., Phillips, L. M., Paulson, J. C., DeFrees, S., Zalipsky, S., Guo, L. S. S., Lefer, A. M. Cardioprotection by liposome-conjugated sialyl lewis(x)-oligosaccharide in myocardial ischaemia and reperfusion injury Cardiovascular Research  1995 30:965-974  DOI:10.1016/s0008-6363(95)00157-3  PMID:8746213
    • Williams, M. A., Kitagawa, H., Datta, A. K., Paulson, J. C., Jamieson, J. C. Large-scale expression of recombinant sialyttransferases and comparison of their kinetic-properties with native enzymes Glycoconjugate Journal  1995 12:755-761  DOI:10.1007/bf00731235  PMID:8748151
    • Phillips, M. L., Schwartz, B. R., Etzioni, A., Bayer, R., Ochs, H. D., Paulson, J. C., Harlan, J. M. Neutrophil adhesion in leukocyte adhesion deficiency syndrome type 2 Journal of Clinical Investigation  1995 96:2898-2906  DOI:10.1172/jci118361  PMID:8675661
    • Datta, A. K., Paulson, J. C. The sialyltransferase sialylmotif participates in binding the donor substrate cmp-neuac Journal of Biological Chemistry  1995 270:1497-1500  PMID:7829476
    • Defrees, S. A., Kosch, W., Way, W., Paulson, J. C., Sabesan, S., Halcomb, R. L., Huang, D. H., Ichikawa, Y., Wong, C. H. Ligand recognition by e-selectin - synthesis, inhibitory activity, and conformational-analysis of bivalent sialyl-lewis-x analogs Journal of the American Chemical Society  1995 117:66-79  DOI:10.1021/ja00106a008
    • Leigh, M. W., Connor, R. J., Kelm, S., Baum, L. G., Paulson, J. C. Receptor specificity of influenza-virus influences severity of illness in ferrets Vaccine  1995 13:1468-1473  DOI:10.1016/0264-410x(95)00004-k  PMID:8578828
    • Winn, R. K., Paulson, J. C., Harlan, J. M. A monoclonal antibody to P-selectin ameliorates injury associated with hemorrhagic shock in rabbits American Journal of Physiology-Heart and Circulatory Physiology  1994 267:H2391-H2397  PMID:7528995
    • Skurk, C., Buerke, M., Guo, J. P., Paulson, J., Lefer, A. M. Sialyl Lewisx-containing oligosaccharide exerts beneficial effects in murine traumatic shock American Journal of Physiology-Heart and Circulatory Physiology  1994 267:H2124-H2131  PMID:7528988
    • Connor, R. J., Kawaoka, Y., Webster, R. G., Paulson, J. C. Receptor specificity in human, avian, and equine h2 and h3 influenza-virus isolates Virology  1994 205:17-23  DOI:10.1006/viro.1994.1615  PMID:7975212
    • Kurose, I., Pothoulakis, C., Lamont, J. T., Anderson, D. C., Paulson, J. C., Miyasaka, M., Wolf, R., Granger, D. N. Clostridium-difficile toxin a-induced microvascular dysfunction - role of histamine Journal of Clinical Investigation  1994 94:1919-1926  DOI:10.1172/jci117542  PMID:7962537
    • Zimmerman, B. J., Paulson, J. C., Arrhenius, T. S., Gaeta, F. C. A., Granger, D. N. Thrombin receptor peptide-mediated leukocyte rolling in rat mesenteric venules - roles of p-selectin and sialyl-lewis-x American Journal of Physiology  1994 267:H1049-H1053  PMID:7522405
    • Kitagawa, H., Paulson, J. C. Differential expression of 5 sialyltransferase genes in human tissues Journal of Biological Chemistry  1994 269:17872-17878  PMID:8027041
    • Jerome, S. N., Dore, M., Paulson, J. C., Smith, C. W., Korthuis, R. J. P-selectin and icam-1-dependent adherence reactions - role in the genesis of postischemic no-reflow American Journal of Physiology  1994 266:H1316-H1321  PMID:7514358
    • Asako, H., Kurose, I., Wolf, R., Defrees, S., Zheng, Z. L., Phillips, M. L., Paulson, J. C., Granger, D. N. Role of h1 receptors and p-selectin in histamine-induced leukocyte rolling and adhesion in postcapillary venules Journal of Clinical Investigation  1994 93:1508-1515  DOI:10.1172/jci117129  PMID:7512982
    • Zimmerman, B. J., Holt, J. W., Paulson, J. C., Anderson, D. C., Miyasaka, M., Tamatani, T., Todd, R. F., Rusche, J. R., Granger, D. N. Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules American Journal of Physiology  1994 266:H847-H853  PMID:8160832
    • Seekamp, A., Till, G. O., Mulligan, M. S., Paulson, J. C., Anderson, D. C., Miyasaka, M., Ward, P. A. Role of selectins in local and remote tissue injury following ischemia and reperfusion American Journal of Pathology  1994 144:592-598  PMCID:PMC7510457
    • Gaudino, J. J., Paulson, J. C. A novel and efficient synthesis of neolacto series gangliosides 3'-nlm(1) and 6'nlm(1) Journal of the American Chemical Society  1994 116:1149-1150  DOI:10.1021/ja00082a054
    • Schuster, M., Wang, P., Paulson, J. C., Wong, C. H. Solid-phase chemical-enzymatic synthesis of glycopeptides and oligosaccharides Journal of the American Chemical Society  1994 116:1135-1136  DOI:10.1021/ja00082a047
    • Kurose, I., Anderson, D. C., Miyasaka, M., Tamatani, T., Paulson, J. C., Todd, R. F., Rusche, J. R., Granger, D. N. Molecular determinants of reperfusion-induced leukocyte adhesion and vascular protein leakage Circulation Research  1994 74:336-343  PMID:7507416
    • Kitagawa, H., Paulson, J. C. Cloning of a novel alpha-2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups Journal of Biological Chemistry  1994 269:1394-1401  PMID:8288606
    • Unverzagt, C., Kelm, S., Paulson, J. C. Chemical and enzymatic-synthesis of multivalent sialoglycopeptides Carbohydrate Research  1994 251:285-301  DOI:10.1016/0008-6215(94)84292-2  PMID:8149376
    • Sabesan, S., Paulson, J. C., Weinstein, J. Separation of gal-beta-1,4glcnac-alpha-2,6-sialyltransferase and gal-beta-1,3(4)glcnac-alpha-2,3-sialyltransferase by affinity-chromatography Methods in Enzymology  1994 247:237-243  PMID:7898356
    • Aubin, Y., Ito, Y., Paulson, J. C., Prestegard, J. H. Structure and dynamics of the sialic-acid moiety of g(m3)-ganglioside at the surface of a magnetically oriented membrane Biochemistry  1993 32:13405-13413  DOI:10.1021/bi00212a005  PMID:8257677
    • Sharar, S. R., Sasaki, S. S., Flaherty, L. C., Paulson, J. C., Harlan, J. M., Winn, R. K. P-selectin blockade does not impair leukocyte host-defense against bacterial peritonitis and soft-tissue infection in rabbits Journal of Immunology  1993 151:4982-4988  PMID:7691961
    • Wallace, J. L., McKnight, W., Miyasaka, M., Tamatani, T., Paulson, J., Anderson, D. C., Granger, D. N., Kubes, P. Role of endothelial adhesion molecules in nsaid-induced gastric-mucosal injury American Journal of Physiology  1993 265:G993-G998  PMID:7694504
    • Winn, R. K., Liggitt, D., Vedder, N. B., Paulson, J. C., Harlan, J. M. Anti-p-selectin monoclonal-antibody attenuates reperfusion injury to the rabbit ear Journal of Clinical Investigation  1993 92:2042-2047  DOI:10.1172/jci116799  PMID:7691890
    • Palmer, D. H., Paulson, J. C., Lanelarsen, C. L., Peulen, V. K., Olson, J. D. Endoscopic carpal-tunnel release - a comparison of 2 techniques with open release Arthroscopy  1993 9:498-508  DOI:10.1016/s0749-8063(05)80396-2  PMID:8280321
    • Ito, Y., Paulson, J. C. Combined use of trans-sialidase and sialyltransferase for enzymatic-synthesis of alpha-neuac2-- 3-beta-gal-or Journal of the American Chemical Society  1993 115:7862-7863  DOI:10.1021/ja00070a036
    • Nelson, J., Couceiro, S. S., Paulson, J. C., Baum, L. G. Influenza-virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium - the role of the host-cell in selection of hemagglutinin receptor specificity Virus Research  1993 29:155-165  PMID:8212857
    • Mulligan, M. S., Lowe, J. B., Larsen, R. D., Paulson, J., Zheng, Z. L., Defrees, S., Maemura, K., Fukuda, M., Ward, P. A. Protective effects of sialylated oligosaccharides in immune-complex induced acute lung injury Journal of Experimental Medicine  1993 178:623-631  DOI:10.1084/jem.178.2.623  PMID:7688029
    • Kitagawa, H., Paulson, J. C. Cloning and expression of human gal-beta-1,3(4)glcnac alpha-2,3-sialyltransferase Biochemical and Biophysical Research Communications  1993 194:375-382  DOI:10.1006/bbrc.1993.1830  PMID:8333853
    • Mulligan, M. S., Paulson, J. C., Defrees, S., Zheng, Z. L., Lowe, J. B., Ward, P. A. Protective effects of oligosaccharides in P-selectin-dependent lung injury Nature  1993 364:149-151  DOI:10.1038/364149a0  PMID:7686631
    • Kurose, I., Kubes, P., Wolf, R., Anderson, D. C., Paulson, J., Miyasaka, M., Granger, D. N. Inhibition of nitric-oxide production - mechanisms of vascular albumin leakage Circulation Research  1993 73:164-171  PMID:7685251
    • Livingston, B. D., Paulson, J. C. Polymerase chain-reaction cloning of a developmentally-regulated member of the sialyltransferase gene family Journal of Biological Chemistry  1993 268:11504-11507  PMID:7685014
    • Herrmann, G. F., Ichikawa, Y., Wandrey, C., Gaeta, F. C. A., Paulson, J. C., Wong, C. H. A new multienzyme system for a one-pot synthesis of sialyl oligosaccharides - combined use of beta-galactosidase and alpha(2,6)-sialyltransferase coupled with regeneration insitu of cmp-sialic acid Tetrahedron Letters  1993 34:3091-3094  DOI:10.1016/s0040-4039(00)93387-2
    • Ito, Y., Gaudino, J. J., Paulson, J. C. Synthesis of bioactive sialosides Pure and Applied Chemistry  1993 65:753-762  DOI:10.1351/pac199365040753
    • Gillespie, W., Paulson, J. C., Kelm, S., Pang, M., Baum, L. G. Regulation of alpha-2,3-sialyltransferase expression correlates with conversion of peanut agglutinin (pna)+ to pna- phenotype in developing thymocytes Journal of Biological Chemistry  1993 268:3801-3804  PMID:8440675
    • Ito, Y., Paulson, J. C. A novel strategy for synthesis of ganglioside-gm3 using an enzymatically produced sialoside glycosyl donor Journal of the American Chemical Society  1993 115:1603-1605  DOI:10.1021/ja00057a071
    • von Andrian, U. H., Berger, E. M., Ramezani, L., Chambers, J. D., Ochs, H. D., Harlan, J. M., Paulson, J. C., Etzioni, A., Arfors, K. E. In vivo behavior of neutrophils from two patients with distinct inherited leukocyte adhesion deficiency syndromes Journal of Clinical Investigation  1993 91:2893-2897  DOI:10.1172/jci116535  PMID:7685776  PMCID:PMC443360
    • Etzioni, A., Frydman, M., Pollack, S., Avidor, I., Phillips, M. L., Paulson, J. C., Gershonibaruch, R. Recurrent severe infections caused by a novel leukocyte adhesion deficiency New England Journal of Medicine  1992 327:1789-1792  DOI:10.1056/nejm199212173272505  PMID:1279426
    • Ichikawa, Y., Lin, Y. C., Dumas, D. P., Shen, G. J., Garciajunceda, E., Williams, M. A., Bayer, R., Ketcham, C., Walker, L. E., Paulson, J. C., Wong, C. H. Chemical-enzymatic synthesis and conformational-analysis of sialyl lewis-x and derivatives Journal of the American Chemical Society  1992 114:9283-9298  DOI:10.1021/ja00050a007
    • Sabesan, S., Duus, J. O., Neira, S., Domaille, P., Kelm, S., Paulson, J. C., Bock, K. Cluster sialoside inhibitors for influenza-virus - synthesis, NMR, and biological studies Journal of the American Chemical Society  1992 114:8363-8375  DOI:10.1021/ja00048a004
    • Gillespie, W., Kelm, S., Paulson, J. C. Cloning and expression of the gal-beta-1,3galnac alpha-2,3-sialyltransferase Journal of Biological Chemistry  1992 267:21004-21010  PMID:1383214
    • Wen, D. X., Livingston, B. D., Medzihradszky, K. F., Kelm, S., Burlingame, A. L., Paulson, J. C. Primary structure of gal-beta-1,3(4)glcnac alpha-2,3-sialyltransferase determined by mass-spectrometry sequence-analysis and molecular-cloning - evidence for a protein motif in the sialyltransferase gene family Journal of Biological Chemistry  1992 267:21011-21019  PMID:1400416
    • Mulligan, M. S., Polley, M. J., Bayer, R. J., Nunn, M. F., Paulson, J. C., Ward, P. A. Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140) Journal of Clinical Investigation  1992 90:1600-1607  DOI:10.1172/jci116029  PMID:1383277  PMCID:PMC443208
    • Herrler, G., Gross, H. J., Imhof, A., Brossmer, R., Milks, G., Paulson, J. C. A synthetic sialic-acid analog is recognized by influenza-c virus as a receptor determinant but is resistant to the receptor-destroying enzyme Journal of Biological Chemistry  1992 267:12501-12505  PMID:1618756
    • Colley, K. J., Lee, E. U., Paulson, J. C. The signal anchor and stem regions of the beta-galactoside alpha-2,6-sialyltransferase may each act to localize the enzyme to the golgi-apparatus Journal of Biological Chemistry  1992 267:7784-7793  PMID:1560012
    • Kelm, S., Paulson, J. C., Rose, U., Brossmer, R., Schmid, W., Bandgar, B. P., Schreiner, E., Hartmann, M., Zbiral, E. Use of sialic-acid analogs to define functional-groups involved in binding to the influenza-virus hemagglutinin European Journal of Biochemistry  1992 205:147-153  DOI:10.1111/j.1432-1033.1992.tb16762.x  PMID:1555576
    • Svensson, E. C., Conley, P. B., Paulson, J. C. Regulated expression of alpha-2,6-sialyltransferase by the liver-enriched transcription factors hnf-1, dbp, and lap Journal of Biological Chemistry  1992 267:3466-3472  PMID:1737800
    • Wen, D. X., Svensson, E. C., Paulson, J. C. Tissue-specific alternative splicing of the beta-galactoside alpha-2,6-sialyltransferase gene Journal of Biological Chemistry  1992 267:2512-2518  PMID:1733948
    • Nishi, T., Weinstein, J., Gillespie, W. M., Paulson, J. C. Complete primary structure of porcine tenascin - detection of tenascin transcripts in adult submaxillary-glands European Journal of Biochemistry  1991 202:643-648  DOI:10.1111/j.1432-1033.1991.tb16418.x  PMID:1722152
    • Sabesan, S., Bock, K., Paulson, J. C. Conformational-analysis of sialyloligosaccharides Carbohydrate Research  1991 218:27-54  DOI:10.1016/0008-6215(91)84084-r  PMID:1802388
    • Kodama, H., Baum, L. G., Paulson, J. C. Synthesis of linkage-specific sialoside substrates for colorimetric assay of neuraminidases Carbohydrate Research  1991 218:111-119  DOI:10.1016/0008-6215(91)84090-2  PMID:1802382
    • Sabesan, S., Duus, J. O., Domaille, P., Kelm, S., Paulson, J. C. Synthesis of cluster sialoside inhibitors for influenza-virus Journal of the American Chemical Society  1991 113:5865-5866  DOI:10.1021/ja00015a052
    • Polley, M. J., Phillips, M. L., Wayner, E., Nudelman, E., Singhal, A. K., Hakomori, S. I., Paulson, J. C. Cd62 and endothelial-cell leukocyte adhesion molecule-1 (elam-1) recognize the same carbohydrate ligand, sialyl-lewis-x Proceedings of the National Academy of Sciences of the United States of America  1991 88:6224-6228  DOI:10.1073/pnas.88.14.6224  PMID:1712483
    • Crocker, P. R., Kelm, S., Dubois, C., Martin, B., McWilliam, A. S., Shotton, D. M., Paulson, J. C., Gordon, S. Purification and properties of sialoadhesin, a sialic acid-binding receptor of murine tissue macrophages EMBO Journal  1991 10:1661-1669  PMID:2050106  PMCID:PMC452836
    • Pozsgay, V., Brisson, J. R., Jennings, H. J., Allen, S., Paulson, J. C. Synthetic oligosaccharides related to group-b streptococcal polysaccharides .5. Combined chemical and enzymatic-synthesis of a pentasaccharide repeating unit of the capsular polysaccharide of type-iii group-b streptococcus and one-dimensional and 2-dimensional NMR spectroscopic studies Journal of Organic Chemistry  1991 56:3377-3385  DOI:10.1021/jo00010a037
    • Pozsgay, V., Gaudino, J., Paulson, J. C., Jennings, H. J. Synthetic oligosaccharides related to group-b streptococcal polysaccharides .6. Chemoenzymatic synthesis of a branching decasaccharide fragment of the capsular polysaccharide of type-iii group-b streptococcus Bioorganic & Medicinal Chemistry Letters  1991 1:391-394  DOI:10.1016/s0960-894x(00)80262-0
    • Baum, L. G., Paulson, J. C. The n2 neuraminidase of human influenza-virus has acquired a substrate-specificity complementary to the hemagglutinin receptor specificity Virology  1991 180:10-15  DOI:10.1016/0042-6822(91)90003-t  PMID:1984642
    • Unverzagt, C., Kunz, H., Paulson, J. C. High-efficiency synthesis of sialyloligosaccharides and sialoglycopeptides Journal of the American Chemical Society  1990 112:9308-9309  DOI:10.1021/ja00181a037
    • Svensson, E. C., Soreghan, B., Paulson, J. C. Organization of the beta-galactoside alpha-2,6-sialyltransferase gene - evidence for the transcriptional regulation of terminal glycosylation Journal of Biological Chemistry  1990 265:20863-20868  PMID:2249992
    • Phillips, M. L., Nudelman, E., Gaeta, F. C. A., Perez, M., Singhal, A. K., Hakomori, S. I., Paulson, J. C. Elam-1 mediates cell-adhesion by recognition of a carbohydrate ligand, sialyl-lex Science  1990 250:1130-1132  DOI:10.1126/science.1701274  PMID:1701274
    • Baum, L. G., Paulson, J. C. Sialyloligosaccharides of the respiratory epithelium in the selection of human influenza virus receptor specificity Acta Histochemica Supplement  1990 35-38  PMID:2091044
    • Herrler, G., Gross, H. J., Milks, G., Paulson, J. C., Klenk, H. D., Brossmer, R. Use of a sialic acid analogue to analyze the importance of the receptor-destroying enzyme for the interaction of influenza c virus with cells Acta Histochemica Supplement  1990 40:39-41  PMID:1965334
    • Colley, K. J., Lee, E. U., Adler, B., Browne, J. K., Paulson, J. C. Conversion of a golgi-apparatus sialyltransferase to a secretory protein by replacement of the nh2-terminal signal anchor with a signal peptide Journal of Biological Chemistry  1989 264:17619-17622  PMID:2808334
    • Paulson, J. C., Colley, K. J. Glycosyltransferases - structure, localization, and control of cell type-specific glycosylation Journal of Biological Chemistry  1989 264:17615-17618  PMID:2681181
    • Gross, H. J., Rose, U., Krause, J. M., Paulson, J. C., Schmid, K., Feeney, R. E., Brossmer, R. Transfer of synthetic sialic-acid analogs to n-linked and o-linked glycoprotein glycans using 4 different mammalian sialytransferases Biochemistry  1989 28:7386-7392  DOI:10.1021/bi00444a036  PMID:2510824
    • Lee, E. U., Roth, J., Paulson, J. C. Alteration of terminal glycosylation sequences on n-linked oligosaccharides of chinese-hamster ovary cells by expression of beta-galactoside alpha-2,6-sialyltransferase Journal of Biological Chemistry  1989 264:13848-13855  PMID:2668274
    • Paulson, J. C., Weinstein, J., Schauer, A. Tissue-specific expression of sialyltransferases Journal of Biological Chemistry  1989 264:10931-10934  PMID:2738054
    • Paulson, J. C. Glycoproteins - what are the sugar chains for Trends in Biochemical Sciences  1989 14:272-276  DOI:10.1016/0968-0004(89)90062-5  PMID:2672447
    • Hanaoka, K., Pritchett, T. J., Takasaki, S., Kochibe, N., Sabesan, S., Paulson, J. C., Kobata, A. 4-O-acetyl-N-acetylneuraminic acid in the N-linked carbohydrate structures of equine and guinea pig alpha 2-macroglobulins, potent inhibitors of influenza virus infection Journal of Biological Chemistry  1989 264:9842-9849  PMID:2470764
    • Pritchett, T. J., Paulson, J. C. Basis for the potent inhibition of influenza-virus infection by equine and guinea-pig alpha-2-macroglobulin Journal of Biological Chemistry  1989 264:9850-9858  PMID:2470765
    • Weis, W., Brown, J. H., Cusack, S., Paulson, J. C., Skehel, J. J., Wiley, D. C. Structure of the influenza-virus hemagglutinin complexed with its receptor, sialic-acid Nature  1988 333:426-431  DOI:10.1038/333426a0  PMID:3374584
    • Taatjes, D. J., Roth, J., Weinstein, J., Paulson, J. C. Post-golgi apparatus localization and regional expression of rat intestinal sialyltransferase detected by immunoelectron microscopy with polypeptide epitope-purified antibody Journal of Biological Chemistry  1988 263:6302-6309  PMID:2452161
    • Ravindranaths, M. H., Paulson, J. C., Irie, R. F. Human-melanoma antigen o-acetylated ganglioside-gd3 is recognized by cancer-antennarius lectin Journal of Biological Chemistry  1988 263:2079-2086  PMID:3339003
    • Weinstein, J., Lee, E. U., McEntee, K., Lai, P. H., Paulson, J. C. Primary structure of beta-galactoside alpha-2,6-sialyltransferase - conversion of membrane-bound enzyme to soluble forms by cleavage of the nh2-terminal signal anchor Journal of Biological Chemistry  1987 262:17735-17743  PMID:3121604
    • Gross, H. J., Bunsch, A., Paulson, J. C., Brossmer, R. Activation and transfer of novel synthetic 9-substituted sialic acids European Journal of Biochemistry  1987 168:595-602  DOI:10.1111/j.1432-1033.1987.tb13458.x  PMID:3665935
    • Taatjes, D. J., Roth, J., Weinstein, J., Paulson, J. C., Shaper, N. L., Shaper, J. H. Codistribution of galactosyltransferase and sialyltransferase - reorganization of trans golgi-apparatus elements in hepatocytes in intact liver and cell-culture European Journal of Cell Biology  1987 44:187-194  PMID:3121331
    • Pritchett, T. J., Brossmer, R., Rose, U., Paulson, J. C. Recognition of mono-valent sialosides by influenza-virus h-3 hemagglutinin Virology  1987 160:502-506  DOI:10.1016/0042-6822(87)90026-2  PMID:3660590
    • Paulson, J. C., Weinstein, J., Ujita, E. L., Riggs, K. J., Lai, P. H. The membrane-binding domain of a rat-liver golgi sialyltransferase Biochemical Society Transactions  1987 15:618-620  PMID:3315771
    • Daniels, R. S., Jeffries, S., Yates, P., Schild, G. C., Rogers, G. N., Paulson, J. C., Wharton, S. A., Douglas, A. R., Skehel, J. J., Wiley, D. C. The receptor-binding and membrane-fusion properties of influenza-virus variants selected using anti-hemagglutinin monoclonal-antibodies EMBO Journal  1987 6:1459-1465  PMID:3608984  PMCID:PMC553952
    • Ravindranath, M. H., Paulson, J. C. O-acetylsialic acid-specific lectin from the crab cancer-anntenarius Methods in Enzymology  1987 138:520-527  PMID:3600345
    • Paulson, J. C., Rogers, G. N. Resialylated erythrocytes for assessment of the specificity of sialyloligosaccharide binding-proteins Methods in Enzymology  1987 138:162-168  PMID:3600320
    • Roth, J., Taatjes, D. J., Weinstein, J., Paulson, J. C., Greenwell, P., Watkins, W. M. Differential subcompartmentation of terminal glycosylation in the golgi-apparatus of intestinal absorptive and goblet cells Journal of Biological Chemistry  1986 261:14307-14312  PMID:3095318
    • Kelm, S., Shukla, A. K., Paulson, J. C., Schauer, R. Reconstitution of the masking effect of sialic-acid groups on sialidase-treated erythrocytes by the action of sialyltransferases Carbohydrate Research  1986 149:59-64  DOI:10.1016/s0008-6215(00)90369-0  PMID:3089604
    • Rogers, G. N., Herrler, G., Paulson, J. C., Klenk, H. D. Influenza-c virus uses 9-o-acetyl-n-acetylneuraminic acid as a high-affinity receptor determinant for attachment to cells Journal of Biological Chemistry  1986 261:5947-5951  PMID:3700379
    • Sabesan, S., Paulson, J. C. Combined chemical and enzymatic-synthesis of sialyloligosaccharides and characterization by 500-mhz h-1 and c-13 NMR-spectroscopy Journal of the American Chemical Society  1986 108:2068-2080  DOI:10.1021/ja00268a056
    • Roth, J., Taatjes, D. J., Lucocq, J. M., Weinstein, J., Paulson, J. C. Demonstration of an extensive tras-tubular network continuous with the golgi-apparatus stack that may function in glycosylation Cell  1985 43:287-295  DOI:10.1016/0092-8674(85)90034-0  PMID:3000603
    • Carroll, S. M., Paulson, J. C. Differential infection of receptor-modified host-cells by receptor-specific influenza-viruses Virus Research  1985 3:165-179  DOI:10.1016/0168-1702(85)90006-1  PMID:4060886
    • Rogers, G. N., Daniels, R. S., Skehel, J. J., Wiley, D. C., Wang, X. F., Higa, H. H., Paulson, J. C. Host-mediated selection of influenza-virus receptor variants - sialic acid alpha-2,6gal-specific clones of a/duck/ukraine/1/63 revert to sialic acid-alpha-2,3gal-specific wild-type inovo Journal of Biological Chemistry  1985 260:7362-7367  PMID:3997874
    • Higa, H. H., Rogers, G. N., Paulson, J. C. Influenza-virus hemagglutinins differentiate between receptor determinants bearing n-acetylneuraminic, n-glycollylneuraminic, and n,o-diacetylneuraminic acids Virology  1985 144:279-282  DOI:10.1016/0042-6822(85)90325-3  PMID:4060591
    • Ravindranath, M. H., Higa, H. H., Cooper, E. L., Paulson, J. C. Purification and characterization of an o-acetylsialic acid-specific lectin from a marine crab cancer-antennarius Journal of Biological Chemistry  1985 260:8850-8856  PMID:4019458
    • Higa, H. H., Paulson, J. C., Weinstein, J. Sialylation of glycoprotein oligosaccharides with n-acetylneuraminic, n-glycolylneuraminic, and n-o-diacetylneuraminic acids Journal of Biological Chemistry  1985 260:8838-8849  PMID:4019457
    • Daniels, R. S., Douglas, A. R., Skehel, J. J., Wiley, D. C., Naeve, C. W., Webster, R. G., Rogers, G. N., Paulson, J. C. Antigenic analyses of influenza-virus hemagglutinins with different receptor-binding specificities Virology  1984 138:174-177  DOI:10.1016/0042-6822(84)90158-2  PMID:6208680
    • Paulson, J. C., Weinstein, J., Desouzaesilva, U. Biosynthesis of a disialylated sequence in n-linked oligosaccharides - identification of an n-acetylglucosaminide (alpha-2- 6)-sialyltransferase in golgi-apparatus from rat-liver European Journal of Biochemistry  1984 140:523-530  DOI:10.1111/j.1432-1033.1984.tb08133.x  PMID:6547092
    • Loomes, L. M., Uemura, K., Childs, R. A., Paulson, J. C., Rogers, G. N., Scudder, P. R., Michalski, J. C., Hounsell, E. F., Taylorrobinson, D., Feizi, T. Erythrocyte receptors for mycoplasma-pneumoniae are sialylated oligosaccharides of ii antigen type Nature  1984 307:560-563  DOI:10.1038/307560a0  PMID:6420710
    • Tai, T., Cahan, L. D., Paulson, J. C., Saxton, R. E., Irie, R. F. Human monoclonal-antibody against ganglioside gd2 - use in development of enzyme-linked immunosorbent-assay for the monitoring of anti-gd2 in cancer-patients Journal of the National Cancer Institute  1984 73:627-633  PMID:6206271
    • Paulson, J. C., Rogers, G. N., Carroll, S. M., Higa, H. H., Pritchett, T., Milks, G., Sabesan, S. Selection of influenza-virus variants based on sialyloligosaccharide receptor specificity Pure and Applied Chemistry  1984 56:797-805  DOI:10.1351/pac198456070797
    • Rogers, G. N., Pritchett, T. J., Lane, J. L., Paulson, J. C. Differential sensitivity of human, avian, and equine influenza-a viruses to a glycoprotein inhibitor of infection - selection of receptor specific variants Virology  1983 131:394-408  DOI:10.1016/0042-6822(83)90507-x  PMID:6197808
    • Tai, T., Paulson, J. C., Cahan, L. D., Irie, R. F. Ganglioside gm2 as a human-tumor antigen (ofa-i-1) Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  1983 80:5392-5396  DOI:10.1073/pnas.80.17.5392  PMID:6193515
    • Rogers, G. N., Paulson, J. C. Receptor determinants of human and animal influenza-virus isolates - differences in receptor specificity of the hemagglutinin-h-3 based on species of origin Virology  1983 127:361-373  DOI:10.1016/0042-6822(83)90150-2  PMID:6868370
    • Cahan, L. D., Singh, R., Paulson, J. C. Sialyloligosaccharide receptors of binding variants of polyoma-virus Virology  1983 130:281-289  DOI:10.1016/0042-6822(83)90083-1  PMID:6316632
    • Rogers, G. N., Paulson, J. C., Daniels, R. S., Skehel, J. J., Wilson, I. A., Wiley, D. C. Single amino-acid substitutions in influenza hemagglutinin change receptor-binding specificity Nature  1983 304:76-78  DOI:10.1038/304076a0  PMID:6191220
    • Corfield, A. P., Higa, H., Paulson, J. C., Schauer, R. The specificity of viral and bacterial sialidases for alpha-(2-3)-linked and alpha-(2-6)-linked sialic acids in glycoproteins Biochimica et Biophysica Acta  1983 744:121-126  DOI:10.1016/0167-4838(83)90080-8  PMID:6301560
    • Carroll, S. M., Paulson, J. C. Complete metal-ion requirement of influenza-virus n1 neuraminidases Archives of Virology  1982 71:273-277  DOI:10.1007/bf01314879  PMID:6808973
    • Paulson, J. C., Weinstein, J., Desouzaesilva, U. Identification of a gal-beta-1 - 3glcnac alpha-2 - 3 sialyltransferase in rat-liver Journal of Biological Chemistry  1982 257:4034-4037  PMID:7068622
    • Cahan, L. D., Irie, R. F., Singh, R., Cassidenti, A., Paulson, J. C. Identification of a human neuroectodermal tumor-antigen (ofa-i-2) as ganglioside gd2 Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  1982 79:7629-7633  DOI:10.1073/pnas.79.24.7629  PMID:6296843
    • Paulson, J. C., Weinstein, J., Dorland, L., Vanhalbeek, H., Vliegenthart, J. F. G. Newcastle-disease virus contains a linkage-specific glycoprotein sialidase - application to the localization of sialic-acid residues in n-linked oligosaccharides of alpha-1 acid glycoprotein Journal of Biological Chemistry  1982 257:2734-2738  PMID:7061446
    • Weinstein, J., Desouzaesilva, U., Paulson, J. C. Purification of a gal-beta-1- 4glcnac alpha-2- 6 sialyltransferase and a gal-beta-1- 3(4)glcnac alpha-2- 3 sialyltransferase to homogeneity from rat-liver Journal of Biological Chemistry  1982 257:3835-3844
    • Sadler, J. E., Beyer, T. A., Oppenheimer, C. L., Paulson, J. C., Prieels, J. P., Rearick, J. I., Hill, R. L. Purification of mammalian glycosyltransferases Methods in Enzymology  1982 83:458-514  PMID:6808302
    • Weinstein, J., Desouzaesilva, U., Paulson, J. C. Sialylation of glycoprotein oligosaccharides n-linked to asparagine - enzymatic characterization of a gal-beta-1- 3(4)glcnac alpha-2- 3 sialyltransferase and a gal-beta-1- 4glcnac alpha-2- 6 sialyltransferase from rat-liver Journal of Biological Chemistry  1982 257:3845-3853
    • Berger, E. G., Buddecke, E., Kamerling, J. P., Kobata, A., Paulson, J. C., Vliegenthart, J. F. G. Structure, biosynthesis and functions of glycoprotein glycans Experientia  1982 38:1129-1162  DOI:10.1007/bf01959725  PMID:6754417
    • Carroll, S. M., Higa, H. H., Paulson, J. C. Different cell-surface receptor determinants of antigenically similar influenza-virus hemagglutinins Journal of Biological Chemistry  1981 256:8357-8363  PMID:6167577
    • Fried, H., Cahan, L. D., Paulson, J. C. Polyoma-virus recognizes specific sialyloligosaccharide receptors on host-cells Virology  1981 109:188-192  DOI:10.1016/0042-6822(81)90485-2  PMID:6258307
    • Markwell, M. A. K., Svennerholm, L., Paulson, J. C. Specific gangliosides function as host-cell receptors for sendai virus Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  1981 78:5406-5410  DOI:10.1073/pnas.78.9.5406  PMID:6272300
    • Cahan, L. D., Paulson, J. C. Polyoma-virus adsorbs to specific sialyloligosaccharide receptors on erythrocytes Virology  1980 103:505-509  DOI:10.1016/0042-6822(80)90208-1  PMID:6247827
    • Markwell, M. A. K., Paulson, J. C. Sendai virus utilizes specific sialyloligosaccharides as host-cell receptor determinants Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  1980 77:5693-5697  DOI:10.1073/pnas.77.10.5693  PMID:6255459
    • Beyer, T. A., Rearick, J. I., Paulson, J. C., Prieels, J. P., Sadler, J. E., Hill, R. L. Biosynthesis of mammalian glycoproteins - glycosylation pathways in the synthesis of the nonreducing terminal sequences Journal of Biological Chemistry  1979 254:2531-2541
    • Sodetz, J. M., Paulson, J. C., McKee, P. A. Carbohydrate composition and identification of blood group A, B, and H oligosaccharide structures on human Factor VIII/von Willebrand factor Journal of Biological Chemistry  1979 254:754-760  PMID:315409
    • Rearick, J. I., Sadler, J. E., Paulson, J. C., Hill, R. L. Enzymatic characterization of beta-d-galactoside alpha-2- 3 sialytransferase from porcine sub-maxillary gland Journal of Biological Chemistry  1979 254:4444-4451  PMID:438198
    • Sadler, J. E., Rearick, J. I., Paulson, J. C., Hill, R. L. Purification to homogeneity of a beta-galactoside alpha-2- 3 sialytransferase and partial-purification of an alpha-n-acetylgalactosaminide alpha-2- 6 sialytransferase from porcine sub-maxillary glands Journal of Biological Chemistry  1979 254:4434-4442  PMID:438196
    • Paulson, J. C., Sadler, J. E., Hill, R. L. Restoration of specific myxovirus receptors to asialoerythrocytes by incorporation of sialic-acid with pure sialytransferases Journal of Biological Chemistry  1979 254:2120-2124  PMID:422571
    • Sadler, J. E., Paulson, J. C., Hill, R. L. Role of sialic-acid in the expression of human mn blood-group antigens Journal of Biological Chemistry  1979 254:2112-2119  PMID:422570
    • Sodetz, J. M., Paulson, J. C., Pizzo, S. V., McKee, P. A. Carbohydrate on human factor viii von willebrand factor - impairment of function by removal of specific galactose residues Journal of Biological Chemistry  1978 253:7202-7206  PMID:100492
    • Prieels, J. P., Pizzo, S. V., Glasgow, L. R., Paulson, J. C., Hill, R. L. Hepatic receptor that specifically binds oligosaccharides containing fucosyl alpha1- 3 n-acetylglucosamine linkages Proceedings of the National Academy of Sciences of the United States of America  1978 75:2215-2219  DOI:10.1073/pnas.75.5.2215  PMID:276862
    • Vaneldik, L. J., Paulson, J. C., Green, R. W., Smith, R. E. Influence of carbohydrate on antigenicity of envelope glycoprotein of avian-myeloblastosis virus and b77 avian-sarcoma virus Virology  1978 86:193-204  DOI:10.1016/0042-6822(78)90020-x  PMID:208246
    • Paulson, J. C., Prieels, J. P., Glasgow, L. R., Hill, R. L. Sialyltransferases and fucosyltransferases in biosynthesis of asparaginyl-linked oligosaccharides in glycoproteins - mutually exclusive glycosylation by beta-galactoside -alpha-2- 6-sialyltransferase and n-acetylglucosaminide -alpha-1- 3-fucosyltransferase Journal of Biological Chemistry  1978 253:5617-5624  PMID:27517
    • Paulson, J. C., Rearick, J. I., Hill, R. L. Enzymatic properties of beta-d-galactoside alpha-2- 6 sialyltransferase from bovine colostrum Journal of Biological Chemistry  1977 252:2363-2371  PMID:849933
    • McClure, W. O., Paulson, J. C. Interaction of colchicine and some related alkaloids with rat-brain tubulin Molecular Pharmacology  1977 13:560-575  PMID:559920
    • Paulson, J. C., Beranek, W. E., Hill, R. L. Purification of a sialyltransferase from bovine colostrum by affinity chromatography on cdp-agarose Journal of Biological Chemistry  1977 252:2356-2362  PMID:849932
    • Paulson, J. C., Hill, R. L., Tanabe, T., Ashwell, G. Reactivation of asialo-rabbit liver binding-protein by resialylation with beta-d-galactoside alpha2- 6 sialyltransferase Journal of Biological Chemistry  1977 252:8624-8628  PMID:411790
    • Glasgow, L. R., Paulson, J. C., Hill, R. L. Systematic purification of 5 glycosidases from streptococcus-(diplococcus)-pneumoniae Journal of Biological Chemistry  1977 252:8615-8623  PMID:21878
    • Paulson, J. C., McClure, W. O. Inhibition of axoplasmic-transport by colchicine, podophyllotoxin, and vinblastine - effect on microtubules Annals of the New York Academy of Sciences  1975 253:517-527  DOI:10.1111/j.1749-6632.1975.tb19225.x  PMID:50035
    • Paulson, J. C., McClure, W. O. Microtubules and axoplasmic-transport - inhibition of transport by podophyllotoxin - interaction with microtubule protein Journal of Cell Biology  1975 67:461-467  DOI:10.1083/jcb.67.2.461  PMID:53233
    • Paulson, J. C., McClure, W. O. Lack of correlation between hallucinogenesis and inhibition of axoplasmic-transport Molecular Pharmacology  1974 10:419-424  PMID:4137280
    • Paulson, J. C., McClure, W. O. Microtubules and axoplasmic-transport Brain Research  1974 73:333-337  DOI:10.1016/0006-8993(74)91053-1  PMID:4133901
    • Paulson, J. C., McClure, W. O. Inhibition of axoplasmic transport by mescaline and other trimethoxyphenylalkylamines Molecular Pharmacology  1973 9:41-50  PMID:4119560
    • Paulson, J. C. Adaptation of oxygen flask method for ashing of cellulosic materials Analytical Chemistry  1963 35:1558-1559  DOI:10.1021/ac60203a070
  • thesis

    • Paulson, J. C. Detection and quantitation of drug-induced inhibition of rapid axoplasmic transport 1974

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Affiliation

member of

  • Society for Glycobiology Member 2010 -
  • The American Society for Biochemistry and Molecular Biology Member 2010 -
  • The American Society for Clinical Investigation Member 2010 -
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Research

research overview

  • Carbohydrate Binding Proteins in Regulation Of Immune Function

    Carbohydrate binding proteins are increasingly recognized to mediate key aspects of cell trafficking and cell signaling in the immune system. At least three families of carbohydrate binding proteins are known to mediate cellular communication among leukocytes. The siglec family now has thirteen members which are expressed on the surface of various white blood cells (e.g. B cells, NK cells, eosinophils, monocytes etc.), and all recognize sialic acid (NeuAc) containing carbohydrate ligands. The best understood for its function is CD22 (siglec-2), which is known to be a negative regulator of B cell receptor signaling. The carbohydrate ligand of CD22 is the sequence NeuAca2,6Gal on N-linked oligosaccharides of glycoproteins. It is required for normal CD22 function since its absence in mutant mice results in marked immuno-suppression in response to vaccination. Our goal is to elucidate the roles of siglec receptors in immune function, and to define biochemical basis for how the interaction with their carbohydrate ligands modulate their function.

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Teaching

advisees

  • graduate advising relationship

    • Elich, Mila, Ph.D.  candidate, 2014 -
    • Kikuchi, Chika, Ph.D.  candidate, 2018 -
    • Duan, Shiteng, Ph.D.  candidate, 2014 - 2019
    • Rillahan, Cory, Ph.D.  candidate, 2008 - 2012
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Service

professional service activities

  • Society for Glycobiology Member
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Background

education and training

  • Ph.D. in Biochemistry, University of Illinois at Urbana-Champaign 1974
  • M.S. in Biochemistry, University of Illinois at Urbana-Champaign 1971
  • A.B. in Chemistry/Biology, MacMurray College 1970

awards and honors

  • Fellowship of the American Association for the Advancement of Science, conferred by American Association for the Advancement of Science, 2016
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Contact

full name

  • James C. Paulson

geographic location

  • Scripps California 

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