recent publications
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academic article
- Marshall, K., Patapoutian, A. Getting a grip on touch receptors Science 2020 368:1311-1312 DOI:10.1126/science.abc7610 PMID:32554582
- Kefauver, J. M., Ward, A. B., Patapoutian, A. Discoveries in structure and physiology of mechanically activated ion channels Nature 2020 587:567-576 DOI:10.1038/s41586-020-2933-1 PMID:33239794
- Baxter, S. L., Keenan, W. T., Athanas, A. J., Proudfoot, J. A., Zangwill, L. M., Ayyagari, R., Liebmann, J. M., Girkin, C. A., Patapoutian, A., Weinreb, R. N. Investigation of associations between Piezo1 mechanoreceptor gain-of-function variants and glaucoma-related phenotypes in humans and mice Scientific Reports 2020 10 DOI:10.1038/s41598-020-76026-0 PMID:33149214 PMCID:PMC7643131
- Marshall, K. L., Saade, D., Ghitani, N., Coombs, A. M., Szczot, M., Keller, J., Ogata, T., Daou, I., Stowers, L., Bonnemann, C. G., Chesler, A. T., Patapoutian, A. PIEZO2 in sensory neurons and urothelial cells coordinates urination Nature 2020 DOI:10.1038/s41586-020-2830-7 PMID:33057202
- Song, Y., Li, D., Farrelly, O., Miles, L., Li, F., Kim, S. E., Lo, T. Y., Wang, F., Li, T., Thompson-Peer, K. L., Gong, J., Murthy, S. E., et al. The mechanosensitive ion channel piezo inhibits axon regeneration Neuron 2019 102:373-389 DOI:10.1016/j.neuron.2019.01.050 PMID:30819546 PMCID:PMC6487666
- Hoffman, B. U., Baba, Y., Griffith, T. N., Mosharov, E. V., Woo, S. H., Roybal, D. D., Karsenty, G., Patapoutian, A., Sulzer, D., Lumpkin, E. A. Merkel cells activate sensory neural pathways through adrenergic synapses Neuron 2018 100:1401-1413 DOI:10.1016/j.neuron.2018.10.034 PMID:30415995
- Nonomura, K., Lukacs, V., Sweet, D. T., Goddard, L. M., Kanie, A., Whitwam, T., Ranade, S. S., Fujimori, T., Kahn, M. L., Patapoutian, A. Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation Proceedings of the National Academy of Sciences of the United States of America 2018 115:12817-12822 DOI:10.1073/pnas.1817070115 PMID:30482854 PMCID:PMC6294938
- Jojoa-Cruz, S., Saotome, K., Murthy, S. E., Tsui, C. C. A., Sansom, M. S. P., Patapoutian, A., Ward, A. B. Cryo-EM structure of the mechanically activated ion channel OSCA1.2 Elife 2018 7 DOI:10.7554/eLife.41845 PMID:30382939 PMCID:PMC6235563
- Murthy, S. E., Dubin, A. E., Whitwam, T., Jojoa-Cruz, S., Cahalan, S. M., Mousavi, S. A. R., Ward, A. B., Patapoutian, A. OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels Elife 2018 7 DOI:10.7554/eLife.41844 PMID:30382938 PMCID:PMC6235560
- Zeng, W. Z., Marshall, K. L., Min, S., Daou, I., Chapleau, M. W., Abboud, F. M., Liberles, S. D., Patapoutian, A. PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex Science 2018 362:464-467 DOI:10.1126/science.aau6324 PMID:30361375
- Murthy, S. E., Loud, M. C., Daou, I., Marshall, K. L., Schwaller, F., Kuhnemund, J., Francisco, A. G., Keenan, W. T., Dubin, A. E., Lewin, G. R., Patapoutian, A. The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice Science Translational Medicine 2018 10 DOI:10.1126/scitranslmed.aat9897 PMID:30305457
- Kefauver, J. M., Saotome, K., Dubin, A. E., Pallesen, J., Cottrell, C. A., Cahalan, S. M., Qiu, Z., Hong, G., Crowley, C. S., Whitwam, T., Lee, W. H., Ward, A. B., et al. Structure of the human volume regulated anion channel Elife 2018 7 DOI:10.7554/eLife.38461 PMID:30095067 PMCID:PMC6086657
- Xu, J., Mathur, J., Vessieres, E., Hammack, S., Nonomura, K., Favre, J., Grimaud, L., Petrus, M., Francisco, A., Li, J., Lee, V., Xiang, F. L., et al. GPR68 senses flow and is essential for vascular physiology Cell 2018 173:762-775 DOI:10.1016/j.cell.2018.03.076 PMID:29677517 PMCID:PMC5951615
- Ma, S., Cahalan, S., LaMonte, G., Grubaugh, N. D., Zeng, W. Z., Murthy, S. E., Paytas, E., Gamini, R., Lukacs, V., Whitwam, T., Loud, M., Lohia, R., et al. Common PIEZO1 allele in African populations causes RBC dehydration and attenuates plasmodium infection Cell 2018 173:443-455 DOI:10.1016/j.cell.2018.02.047 PMID:29576450 PMCID:PMC5889333
- Saotome, K., Murthy, S. E., Kefauver, J. M., Whitwam, T., Patapoutian, A., Ward, A. B. Structure of the mechanically activated ion channel Piezo1 Nature 2018 554:481-486 DOI:10.1038/nature25453 PMID:29261642
- Murthy, S. E., Dubin, A. E., Patapoutian, A. Piezos thrive under pressure: mechanically activated ion channels in health and disease Nature Reviews Molecular Cell Biology 2017 18:771-783 DOI:10.1038/nrm.2017.92 PMID:28974772
- Dubin, A. E., Murthy, S., Lewis, A. H., Brosse, L., Cahalan, S. M., Grandl, J., Coste, B., Patapoutian, A. Editorial note to: endogenous Piezo1 can confound mechanically activated channel identification and characterization Neuron 2017 94:265-265 DOI:10.1016/j.neuron.2017.03.041 PMID:28426960
- Nonomura, K., Woo, S. H., Chang, R. B., Gillich, A., Qiu, Z., Francisco, A. G., Ranade, S. S., Liberles, S. D., Patapoutian, A. Piezo2 senses airway stretch and mediates lung inflation-induced apnoea Nature 2017 541:176-181 DOI:10.1038/nature20793 PMID:28002412 PMCID:PMC5267560
- Dubin, A. E., Murthy, S., Lewis, A. H., Brosse, L., Cahalan, S. M., Grandl, J., Coste, B., Patapoutian, A. Endogenous Piezo1 can confound mechanically activated channel identification and characterization Neuron 2017 94:266-270 DOI:10.1016/j.neuron.2017.03.039 PMID:28426961
- Wu, Z., Grillet, N., Zhao, B., Cunningham, C., Harkins-Perry, S., Coste, B., Ranade, S., Zebarjadi, N., Beurg, M., Fettiplace, R., Patapoutian, A., Mueller, U. Mechanosensory hair cells express two molecularly distinct mechanotransduction channels Nature Neuroscience 2017 20:24-33 DOI:10.1038/nn.4449 PMID:27893727 PMCID:PMC5191906
- Syeda, R., Florendo, M. N., Cox, C. D., Kefauver, J. M., Santos, J. S., Martinac, B., Patapoutian, A. Piezo1 channels are inherently mechanosensitive Cell Reports 2016 17:1739-1746 DOI:10.1016/j.celrep.2016.10.033 PMID:27829145 PMCID:PMC5129625
- Syeda, R., Qiu, Z., Dubin, A. E., Murthy, S. E., Florendo, M. N., Mason, D. E., Mathur, J., Cahalan, S. M., Peters, E. C., Montal, M., Patapoutian, A. LRRC8 proteins form volume-regulated anion channels that sense ionic strength Cell 2016 164:499-511 DOI:10.1016/j.cell.2015.12.031 PMID:26824658 PMCID:PMC4733249
- Woo, S. H., Lukacs, V., de Nooij, J. C., Zaytseva, D., Criddle, C. R., Francisco, A., Jessell, T. M., Wilkinson, K. A., Patapoutian, A. Piezo2 is the principal mechanotransduction channel for proprioception Nature Neuroscience 2015 18:1756-1762 DOI:10.1038/nn.4162 PMID:26551544 PMCID:PMC4661126
- Lukacs, V., Mathur, J., Mao, R., Bayrak-Toydemir, P., Procter, M., Cahalan, S. M., Kim, H. J., Bandell, M., Longo, N., Day, R. W., Stevenson, D. A., Patapoutian, A., et al. Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia Nature Communications 2015 6:8329 DOI:10.1038/ncomms9329 PMID:26387913 PMCID:PMC4578306
- Syeda, R., Xu, J., Dubin, A. E., Coste, B., Mathur, J., Huynh, T., Matzen, J., Lao, J., Tully, D. C., Engels, I. H., Petrassi, H. M., Schumacher, A. M., et al. Chemical activation of the mechanotransduction channel Piezo1 Elife 2015 4:e07369 DOI:10.7554/eLife.07369 PMID:26001275 PMCID:PMC4456433
- Cahalan, S. M., Lukacs, V., Ranade, S. S., Chien, S., Bandell, M., Patapoutian, A. Piezo1 links mechanical forces to red blood cell volume Elife 2015 4:e07370 DOI:10.7554/eLife.07370 PMID:26001274 PMCID:PMC4456639
- Wieskopf, J. S., Mathur, J., Limapichat, W., Post, M. R., Al-Qazzaz, M., Sorge, R. E., Martin, L. J., Zaykin, D. V., Smith, S. B., Freitas, K., Austin, J. S., Dai, F., et al. The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors Science Translational Medicine 2015 7:287ra72 DOI:10.1126/scitranslmed.3009986 PMID:25972004 PMCID:PMC5018401
- Coste, B., Murthy, S. E., Mathur, J., Schmidt, M., Mechioukhi, Y., Delmas, P., Patapoutian, A. Piezo1 ion channel pore properties are dictated by C-terminal region Nature Communications 2015 6:7223 DOI:10.1038/ncomms8223 PMID:26008989 PMCID:PMC4445471
- Woo, S. H., Lumpkin, E. A., Patapoutian, A. Merkel cells and neurons keep in touch Trends in Cell Biology 2015 25:74-81 DOI:10.1016/j.tcb.2014.10.003 PMID:25480024 PMCID:PMC4312710
- Ranade, S. S., Syeda, R., Patapoutian, A. Mechanically activated ion channels Neuron 2015 87:1162-1179 DOI:10.1016/j.neuron.2015.08.032 PMID:26402601 PMCID:PMC4582600
- Ranade, S. S., Woo, S. H., Dubin, A. E., Moshourab, R. A., Wetzel, C., Petrus, M., Mathur, J., Begay, V., Coste, B., Mainquist, J., Wilson, A. J., Francisco, A. G., et al. Piezo2 is the major transducer of mechanical forces for touch sensation in mice Nature 2014 516:121-125 DOI:10.1038/nature13980 PMID:25471886 PMCID:PMC4380172
- Ranade, S. S., Qiu, Z., Woo, S. H., Hur, S. S., Murthy, S. E., Cahalan, S. M., Xu, J., Mathur, J., Bandell, M., Coste, B., Li, Y. S. J., Chien, S., et al. Piezo1, a mechanically activated ion channel, is required for vascular development in mice Proceedings of the National Academy of Sciences of the United States of America 2014 111:10347-10352 DOI:10.1073/pnas.1409233111 PMID:24958852 PMCID:PMC4104881
- Rooney, L., Vidal, A., D'Souza, A. M., Devereux, N., Masick, B., Boissel, V., West, R., Head, V., Stringer, R., Lao, J., Petrus, M. J., Patapoutian, A., et al. Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists Journal of Medicinal Chemistry 2014 57:5129-5140 DOI:10.1021/jm401986p PMID:24884675
- Maksimovic, S., Nakatani, M., Baba, Y., Nelson, A. M., Marshall, K. L., Wellnitz, S. A., Firozi, P., Woo, S. H., Ranade, S., Patapoutian, A., Lumpkin, E. A. Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors Nature 2014 509:617-621 DOI:10.1038/nature13250 PMID:24717432 PMCID:PMC4097312
- Woo, S. H., Ranade, S., Weyer, A. D., Dubin, A. E., Baba, Y., Qiu, Z., Petrus, M., Miyamoto, T., Reddy, K., Lumpkin, E. A., Stucky, C. L., Patapoutian, A. Piezo2 is required for Merkel-cell mechanotransduction Nature 2014 509:622-626 DOI:10.1038/nature13251 PMID:24717433 PMCID:PMC4039622
- Qiu, Z., Dubin, A. E., Mathur, J., Tu, B., Reddy, K., Miraglia, L. J., Reinhardt, J., Orth, A. P., Patapoutian, A. SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel Cell 2014 157:447-458 DOI:10.1016/j.cell.2014.03.024 PMID:24725410 PMCID:PMC4023864
- Kim, S. E., Patapoutian, A., Grandl, J. Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations PLoS One 2013 8:e59593 DOI:10.1371/journal.pone.0059593 PMID:23555720 PMCID:PMC3608658
- Coste, B., Houge, G., Murray, M. F., Stitziel, N., Bandell, M., Giovanni, M. A., Philippakis, A., Hoischen, A., Riemer, G., Steen, U., Steen, V. M., Mathur, J., et al. Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis Proceedings of the National Academy of Sciences of the United States of America 2013 110:4667-4672 DOI:10.1073/pnas.1221400110 PMID:23487782 PMCID:PMC3607045
- Coste, B., Patapoutian, A. Neuroscience: Salty sensations Nature 2013 494:44-45 DOI:10.1038/nature11946 PMID:23364688
- Albuisson, J., Murthy, S. E., Bandell, M., Coste, B., Louis-dit-Picard, H., Mathur, J., Feneant-Thibault, M., Tertian, G., de Jaureguiberry, J. P., Syfuss, P. Y., Cahalan, S., Garcon, L., et al. Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels Nature Communications 2013 4:1884 DOI:10.1038/ncomms2899 PMID:23695678 PMCID:PMC3674779
- Dubin, A. E., Schmidt, M., Mathur, J., Petrus, M. J., Xiao, B. L., Coste, B., Patapoutian, A. Inflammatory signals enhance piezo2-mediated mechanosensitive currents Cell Reports 2012 2:511-517 DOI:10.1016/j.celrep.2012.07.014 PMID:22921401 PMCID:PMC3462303
- Bandell, M., Patapoutian, A. A hot new channel Nature Neuroscience 2012 15:931-933 DOI:10.1038/nn.3148 PMID:22735512
- Coste, B., Xiao, B. L., Santos, J. S., Syeda, R., Grandl, J., Spencer, K. S., Kim, S. E., Schmidt, M., Mathur, J., Dubin, A. E., Montal, M., Patapoutian, A. Piezo proteins are pore-forming subunits of mechanically activated channels Nature 2012 483:176-181 DOI:10.1038/nature10812 PMID:22343900 PMCID:PMC3297710
- Kim, S. E., Coste, B., Chadha, A., Cook, B., Patapoutian, A. The role of Drosophila Piezo in mechanical nociception Nature 2012 483:209-212 DOI:10.1038/nature10801 PMID:22343891 PMCID:PMC3297676
- Blasius, A. L., Dubin, A. E., Petrus, M. J., Lim, B. K., Narezkina, A., Criado, J. R., Wills, D. N., Xia, Y., Moresco, E. M. Y., Ehlers, C., Knowlton, K. U., Patapoutian, A., et al. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype Proceedings of the National Academy of Sciences of the United States of America 2011 108:19413-19418 DOI:10.1073/pnas.1117020108 PMID:22087007 PMCID:PMC3228463
- Miyamoto, T., Patapoutian, A. Why does morphine make you itch? Cell 2011 147:261-262 DOI:10.1016/j.cell.2011.09.026 PMID:22000005
- Miyamoto, T., Petrus, M. J., Dubin, A. E., Patapoutian, A. TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin Nature Communications 2011 2:369 DOI:10.1038/ncomms1371 PMID:21712817 PMCID:PMC3320851
- Xiao, B. L., Coste, B., Mathur, J., Patapoutian, A. Temperature-dependent STIM1 activation induces Ca(2+) influx and modulates gene expression Nature Chemical Biology 2011 7:351-358 DOI:10.1038/nchembio.558 PMID:21499266 PMCID:PMC3097298
- Xiao, B. L., Patapoutian, A. Scratching the surface: A role of pain-sensing TRPA1 in itch Nature Neuroscience 2011 14:540-542 DOI:10.1038/nn.2813 PMID:21522144
- del Camino, D., Murphy, S., Heiry, M., Barrett, L. B., Earley, T. J., Cook, C. A., Petrus, M. J., Zhao, M., D'Amours, M., Deering, N., Brenner, G. J., Costigan, M., et al. TRPA1 contributes to cold hypersensitivity Journal of Neuroscience 2010 30:15165-15174 DOI:10.1523/jneurosci.2580-10.2010 PMID:21068322 PMCID:PMC3021322
- Dubin, A. E., Patapoutian, A. Nociceptors: The sensors of the pain pathway Journal of Clinical Investigation 2010 120:3760-3772 DOI:10.1172/jci42843 PMID:21041958 PMCID:PMC2964977
- Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., Dubin, A. E., Patapoutian, A. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels Science 2010 330:55-60 DOI:10.1126/science.1193270 PMID:20813920 PMCID:PMC3062430
- Grandl, J., Kim, S. E., Uzzell, V., Bursulaya, B., Petrus, M., Bandell, M., Patapoutian, A. Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain Nature Neuroscience 2010 13:708-714 DOI:10.1038/nn.2552 PMID:20414199 PMCID:PMC2876202
- Macpherson, L. J., Patapoutian, A. Channels: Flies feel your pain Nature Chemical Biology 2010 6:252-253 DOI:10.1038/nchembio.339 PMID:20300095
- Bandell, M., Patapoutian, A. Itching for insight Cell 2009 139:1224-1226 DOI:10.1016/j.cell.2009.12.012 PMID:20064368
- Schmidt, M., Dubin, A. E., Petrus, M. J., Earley, T. J., Patapoutian, A. Nociceptive signals induce trafficking of TRPA1 to the plasma membrane Neuron 2009 64:498-509 DOI:10.1016/j.neuron.2009.09.030 PMID:19945392 PMCID:PMC2854037
- Miyamoto, T., Dubin, A. E., Petrus, M. J., Patapoutian, A. TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice PLoS One 2009 4:e7596 DOI:10.1371/journal.pone.0007596 PMID:19893614 PMCID:PMC2764051
- Mandadi, S., Sokabe, T., Shibasaki, K., Katanosaka, K., Mizuno, A., Moqrich, A., Patapoutian, A., Fukumi-Tominaga, T., Mizumura, K., Tominaga, M. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP Pflugers Archiv-European Journal of Physiology 2009 458:1093-1102 DOI:10.1007/s00424-009-0703-x PMID:19669158 PMCID:PMC2745623
- Mandadi, S., Nakanishi, S. T., Takashima, Y., Dhaka, A., Patapoutian, A., McKemy, D. D., Whelan, P. J. Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels Neuroscience 2009 162:1377-1397 DOI:10.1016/j.neuroscience.2009.05.063 PMID:19482068 PMCID:PMC2880570
- Hu, H. Z., Bandell, M., Petrus, M. J., Zhu, M. X., Patapoutian, A. Zinc activates damage-sensing TRPA1 ion channels Nature Chemical Biology 2009 5:183-190 DOI:10.1038/nchembio.146 PMID:19202543 PMCID:PMC2677965
- Hu, H. Z., Grandl, J., Bandell, M., Petrus, M., Patapoutian, A. Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4 Proceedings of the National Academy of Sciences of the United States of America 2009 106:1626-1631 DOI:10.1073/pnas.0812209106 PMID:19164517 PMCID:PMC2635798
- Dhaka, A., Uzzell, V., Dubin, A. E., Mathur, J., Petrus, M., Bandell, M., Patapoutian, A. TRPV1 is activated by both acidic and basic pH Journal of Neuroscience 2009 29:153-158 DOI:10.1523/jneurosci.4901-08.2009 PMID:19129393 PMCID:PMC2729567
- Patapoutian, A., Tate, S., Woolf, C. J. Transient receptor potential channels: Targeting pain at the source Nature Reviews Drug Discovery 2009 8:55-68 DOI:10.1038/nrd2757 PMID:19116627 PMCID:PMC2755576
- Xiao, B., Dubin, A. E., Bursulaya, B., Viswanath, V., Jegla, T. J., Patapoutian, A. Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels Journal of Neuroscience 2008 28:9640-9651 DOI:10.1523/jneurosci.2772-08.2008 PMID:18815250 PMCID:PMC2678945
- Grandl, J., Hu, H. Z., Bandell, M., Bursulaya, B., Schmidt, M., Petrus, M., Patapoutian, A. Pore region of TRPV3 ion channel is specifically required for heat activation Nature Neuroscience 2008 11:1007-1013 DOI:10.1038/nn.2169 PMID:19160498 PMCID:PMC2685190
- Dhaka, A., Earley, T. J., Watson, J., Patapoutian, A. Visualizing cold spots: TRPM8-expressing sensory neurons and their projections Journal of Neuroscience 2008 28:566-575 DOI:10.1523/jneurosci.3976-07.2008 PMID:18199758
- Petrus, M., Peier, A. M., Bandell, M., Hwang, S. W., Huynh, T., Olney, N., Jegla, T., Patapoutian, A. A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition Molecular Pain 2007 3:40 DOI:10.1186/1744-8069-3-40 PMID:18086313 PMCID:PMC2222610
- Macpherson, L. J., Xiao, B., Kwan, K. Y., Petrus, M. J., Dubin, A. E., Hwang, S., Cravatt, B., Corey, D. P., Patapoutian, A. An ion channel essential for sensing chemical damage Journal of Neuroscience 2007 27:11412-11415 DOI:10.1523/jneurosci.3600-07.2007 PMID:17942735
- Bandell, M., Macpherson, L. J., Patapoutian, A. From chills to chilis: Mechanisms for thermosensation and chemesthesis via thermoTRPs Current Opinion in Neurobiology 2007 17:490-497 DOI:10.1016/j.conb.2007.07.014 PMID:17706410 PMCID:PMC2080617
- Dhaka, A., Murray, A. N., Mathur, J., Earley, T. J., Petrus, M. J., Patapoutian, A. TRPM8 is required for cold sensation in mice Neuron 2007 54:371-378 DOI:10.1016/j.neuron.2007.02.024 PMID:17481391
- Kindt, K. S., Viswanath, V., Macpherson, L., Quast, K., Hu, H. Z., Patapoutian, A., Schafer, W. R. Caenorhabditis elegans TRPA-1 functions in mechanosensation Nature Neuroscience 2007 10:568-577 DOI:10.1038/nn1886 PMID:17450139
- Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F., Patapoutian, A. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines Nature 2007 445:541-545 DOI:10.1038/nature05544 PMID:17237762
- McCleverty, C. J., Koesema, E., Patapoutian, A., Lesley, S. A., Kreusch, A. Crystal structure of the human TRPV2 channel ankyrin repeat domain Protein Science 2006 15:2201-2206 DOI:10.1110/ps.062357206 PMID:16882997 PMCID:PMC2242602
- Saghatelian, A., McKinney, M. K., Bandell, M., Patapoutian, A., Cravatt, B. F. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels Biochemistry 2006 45:9007-9015 DOI:10.1021/bi0608008 PMID:16866345
- Macpherson, L. J., Hwang, S. W., Miyamoto, T., Dubin, A. E., Patapoutian, A., Story, G. M. More than cool: promiscuous relationships of menthol and other sensory compounds Molecular and Cellular Neuroscience 2006 32:335-343 DOI:10.1016/j.mcn.2006.05.005 PMID:16829128
- Patapoutian, A.*, Macpherson, L.* Channeling pain Nature Medicine 2006 12:506-507 DOI:10.1038/nm0506-506 PMID:16675993 (* = equal contribution)
- Bandell, M., Dubin, A. E., Petrus, M. J., Orth, A., Mathur, J., Hwang, S. W., Patapoutian, A. High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol Nature Neuroscience 2006 9:493-500 DOI:10.1038/nn1665 PMID:16520735
- Dhaka, A., Viswanath, V., Patapoutian, A. TRP ion channels and temperature sensation Annual Review of Neuroscience 2006 29:135-161 DOI:10.1146/annurev.neuro.29.051605.112958 PMID:16776582
- Macpherson, L. J., Geierstanger, B. H., Viswanath, V., Bandell, M., Eid, S. R., Hwang, S., Patapoutian, A. The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin Current Biology 2005 15:929-934 DOI:10.1016/j/cub.2005.04.018 PMID:15916949
- Moqrich, A., Hwang, S. W., Earley, T. J., Petrus, M. J., Murray, A. N., Spencer, K. S. R., Andahazy, M., Story, G. M., Patapoutian, A. Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin Science 2005 307:1468-1472 DOI:10.1126/science.1108609 PMID:15746429
- Rosenzweig, M., Brennan, K. M., Tayler, T. D., Phelps, P. O., Patapoutian, A., Garrity, P. A. The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis Genes & Development 2005 19:419-424 DOI:10.1101/gad.1278205 PMID:15681611 PMCID:PMC548941
- Patapoutian, A. TRP channels and thermosensation Chemical Senses 2005 30:i193-i194 DOI:10.1093/chemse/bjh180 PMID:15738110
- Patapoutian, A., Wood, J. N. Mechanisms of nociception: molecules to behaviour Journal of Neurobiology 2004 61:1-2 DOI:10.1002/neu.20092
- Moqrich, A., Earley, T. J., Watson, J., Andahazy, M., Backus, C., Martin-Zanca, D., Wright, D. E., Reichardt, L. F., Patapoutian, A. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate Nature Neuroscience 2004 7:812-818 DOI:10.1038/nn1283 PMID:15247919 PMCID:PMC2693051
- Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., Patapoutian, A. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin Neuron 2004 41:849-857 DOI:10.1016/s0896-6273(04)00150-3 PMID:15046718
- Viswanath, V., Story, G. M., Peier, A. M., Petrus, M. J., Hwang, S. W., Patapoutian, A., Jegla, T. Ion channels: Opposite thermosensor in fruitfly and mouse Nature 2003 423:822-823 DOI:10.1038/423822a PMID:12815418
- Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., McIntyre, P., Jegla, T., et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures Cell 2003 112:819-829 DOI:10.1016/s0092-8674(03)00158-2 PMID:12654248
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- Su, A. I., Cooke, M. P., Ching, K. A., Hakak, Y., Walker, J. R., Wiltshire, T., Orth, A. P., Vega, R. G., Sapinoso, L. M., Moqrich, A., Patapoutian, A., Hampton, G. M., et al. Large-scale analysis of the human and mouse transcriptomes Proceedings of the National Academy of Sciences of the United States of America 2002 99:4465-4470 DOI:10.1073/pnas.012025199 PMID:11904358 PMCID:PMC123671
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- Patapoutian, A. Making the pain connection Neuron 2001 31:4-6 DOI:10.1016/s0896-6273(01)00352-x PMID:11498043
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- Patapoutian, A., Reichardt, L. F. Roles of Wnt proteins in neural development and maintenance Current Opinion in Neurobiology 2000 10:392-399 DOI:10.1016/s0959-4388(00)00100-8 PMID:10851180
- Patapoutian, A., Backus, C., Kispert, A., Reichardt, L. F. Regulation of neurotrophin-3 expression by epithelial mesenchymal interactions: the role of Wnt factors Science 1999 283:1180-1183 DOI:10.1126/science.283.5405.1180 PMID:10024246 PMCID:PMC2710127
- Farinas, I., Wilkinson, G. A., Backus, C., Reichardt, L. F., Patapoutian, A. Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo Neuron 1998 21:325-334 DOI:10.1016/s0896-6273(00)80542-5 PMID:9728914 PMCID:PMC2711510
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- Patapoutian, A., Yoon, J. K., Miner, J. H., Wang, S. L., Stark, K., Wold, B. Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome Development 1995 121:3347-3358 PMID:7588068
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