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Patapoutian, Ardem
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Patapoutian, Ardem

Faculty Member
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Positions

  • 2017 - Professor, Neuroscience , Scripps Research
  • 2013 - 2013 HHMI Investigator, Howard Hughes Medical Institute , University of California, San Francisco
  • 2010 - Professor, Dorris Neuroscience Center , Scripps Research
  • 2006 - Director of Discovery Research, Genomics Institute of the Novartis Research Foundation (GNF)
  • 2001 - Adjunct Professor, Graduate Program in Neurosciences, University of California, San Diego
  • 2000 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2013 - 2017 Professor, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2008 - 2012 Professor, Cell Biology , Scripps Research
  • 2005 - 2008 Associate Professor, Cell Biology , Scripps Research
  • 2002 - 2005 Head of Neuroscience, Genomics Institute of the Novartis Research Foundation (GNF)
  • 2000 - 2005 Assistant Professor, Cell Biology , Scripps Research
  • 1996 - 2000 Postdoctoral Fellow with Dr. Louis Reichardt, University of California, San Francisco
Dr. Ardem Patapoutian studies the molecular basis of the sense of touch by using genomics, imaging, and transgenic technologies to identify and characterize ion channel proteins involved in the perception of distinct thermal, mechanical, and chemical stimuli.

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  • ardem@scripps.edu

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  • Ardem Patapoutian, Ph.D.
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Publications

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    • Marshall, K., Patapoutian, A. Getting a grip on touch receptors Science  2020 368:1311-1312  DOI:10.1126/science.abc7610  PMID:32554582
    • Marshall, K. L., Saade, D., Ghitani, N., Coombs, A. M., Szczot, M., Keller, J., Ogata, T., Daou, I., Stowers, L., Bonnemann, C. G., Chesler, A. T., Patapoutian, A. PIEZO2 in sensory neurons and urothelial cells coordinates urination Nature  2020  DOI:10.1038/s41586-020-2830-7  PMID:33057202
    • Song, Y., Li, D., Farrelly, O., Miles, L., Li, F., Kim, S. E., Lo, T. Y., Wang, F., Li, T., Thompson-Peer, K. L., Gong, J., Murthy, S. E., et al. The mechanosensitive ion channel piezo inhibits axon regeneration Neuron  2019 102:373-389  DOI:10.1016/j.neuron.2019.01.050  PMID:30819546  PMCID:PMC6487666
    • Hoffman, B. U., Baba, Y., Griffith, T. N., Mosharov, E. V., Woo, S. H., Roybal, D. D., Karsenty, G., Patapoutian, A., Sulzer, D., Lumpkin, E. A. Merkel cells activate sensory neural pathways through adrenergic synapses Neuron  2018 100:1401-1413  DOI:10.1016/j.neuron.2018.10.034  PMID:30415995
    • Nonomura, K., Lukacs, V., Sweet, D. T., Goddard, L. M., Kanie, A., Whitwam, T., Ranade, S. S., Fujimori, T., Kahn, M. L., Patapoutian, A. Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation Proceedings of the National Academy of Sciences of the United States of America  2018 115:12817-12822  DOI:10.1073/pnas.1817070115  PMID:30482854  PMCID:PMC6294938
    • Jojoa-Cruz, S., Saotome, K., Murthy, S. E., Tsui, C. C. A., Sansom, M. S. P., Patapoutian, A., Ward, A. B. Cryo-EM structure of the mechanically activated ion channel OSCA1.2 Elife  2018 7  DOI:10.7554/eLife.41845  PMID:30382939  PMCID:PMC6235563
    • Murthy, S. E., Dubin, A. E., Whitwam, T., Jojoa-Cruz, S., Cahalan, S. M., Mousavi, S. A. R., Ward, A. B., Patapoutian, A. OSCA/TMEM63 are an evolutionarily conserved family of mechanically activated ion channels Elife  2018 7  DOI:10.7554/eLife.41844  PMID:30382938  PMCID:PMC6235560
    • Zeng, W. Z., Marshall, K. L., Min, S., Daou, I., Chapleau, M. W., Abboud, F. M., Liberles, S. D., Patapoutian, A. PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex Science  2018 362:464-467  DOI:10.1126/science.aau6324  PMID:30361375
    • Murthy, S. E., Loud, M. C., Daou, I., Marshall, K. L., Schwaller, F., Kuhnemund, J., Francisco, A. G., Keenan, W. T., Dubin, A. E., Lewin, G. R., Patapoutian, A. The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice Science Translational Medicine  2018 10  DOI:10.1126/scitranslmed.aat9897  PMID:30305457
    • Kefauver, J. M., Saotome, K., Dubin, A. E., Pallesen, J., Cottrell, C. A., Cahalan, S. M., Qiu, Z., Hong, G., Crowley, C. S., Whitwam, T., Lee, W. H., Ward, A. B., et al. Structure of the human volume regulated anion channel Elife  2018 7  DOI:10.7554/eLife.38461  PMID:30095067  PMCID:PMC6086657
    • Xu, J., Mathur, J., Vessieres, E., Hammack, S., Nonomura, K., Favre, J., Grimaud, L., Petrus, M., Francisco, A., Li, J., Lee, V., Xiang, F. L., et al. GPR68 senses flow and is essential for vascular physiology Cell  2018 173:762-775  DOI:10.1016/j.cell.2018.03.076  PMID:29677517  PMCID:PMC5951615
    • Ma, S., Cahalan, S., LaMonte, G., Grubaugh, N. D., Zeng, W. Z., Murthy, S. E., Paytas, E., Gamini, R., Lukacs, V., Whitwam, T., Loud, M., Lohia, R., et al. Common PIEZO1 allele in African populations causes RBC dehydration and attenuates plasmodium infection Cell  2018 173:443-455  DOI:10.1016/j.cell.2018.02.047  PMID:29576450  PMCID:PMC5889333
    • Saotome, K., Murthy, S. E., Kefauver, J. M., Whitwam, T., Patapoutian, A., Ward, A. B. Structure of the mechanically activated ion channel Piezo1 Nature  2018 554:481-486  DOI:10.1038/nature25453  PMID:29261642
    • Murthy, S. E., Dubin, A. E., Patapoutian, A. Piezos thrive under pressure: mechanically activated ion channels in health and disease Nature Reviews Molecular Cell Biology  2017 18:771-783  DOI:10.1038/nrm.2017.92  PMID:28974772
    • Dubin, A. E., Murthy, S., Lewis, A. H., Brosse, L., Cahalan, S. M., Grandl, J., Coste, B., Patapoutian, A. Editorial note to: endogenous Piezo1 can confound mechanically activated channel identification and characterization Neuron  2017 94:265-265  DOI:10.1016/j.neuron.2017.03.041  PMID:28426960
    • Nonomura, K., Woo, S. H., Chang, R. B., Gillich, A., Qiu, Z., Francisco, A. G., Ranade, S. S., Liberles, S. D., Patapoutian, A. Piezo2 senses airway stretch and mediates lung inflation-induced apnoea Nature  2017 541:176-181  DOI:10.1038/nature20793  PMID:28002412  PMCID:PMC5267560
    • Dubin, A. E., Murthy, S., Lewis, A. H., Brosse, L., Cahalan, S. M., Grandl, J., Coste, B., Patapoutian, A. Endogenous Piezo1 can confound mechanically activated channel identification and characterization Neuron  2017 94:266-270  DOI:10.1016/j.neuron.2017.03.039  PMID:28426961
    • Wu, Z., Grillet, N., Zhao, B., Cunningham, C., Harkins-Perry, S., Coste, B., Ranade, S., Zebarjadi, N., Beurg, M., Fettiplace, R., Patapoutian, A., Mueller, U. Mechanosensory hair cells express two molecularly distinct mechanotransduction channels Nature Neuroscience  2017 20:24-33  DOI:10.1038/nn.4449  PMID:27893727  PMCID:PMC5191906
    • Syeda, R., Florendo, M. N., Cox, C. D., Kefauver, J. M., Santos, J. S., Martinac, B., Patapoutian, A. Piezo1 channels are inherently mechanosensitive Cell Reports  2016 17:1739-1746  DOI:10.1016/j.celrep.2016.10.033  PMID:27829145  PMCID:PMC5129625
    • Syeda, R., Qiu, Z., Dubin, A. E., Murthy, S. E., Florendo, M. N., Mason, D. E., Mathur, J., Cahalan, S. M., Peters, E. C., Montal, M., Patapoutian, A. LRRC8 proteins form volume-regulated anion channels that sense ionic strength Cell  2016 164:499-511  DOI:10.1016/j.cell.2015.12.031  PMID:26824658  PMCID:PMC4733249
    • Woo, S. H., Lukacs, V., de Nooij, J. C., Zaytseva, D., Criddle, C. R., Francisco, A., Jessell, T. M., Wilkinson, K. A., Patapoutian, A. Piezo2 is the principal mechanotransduction channel for proprioception Nature Neuroscience  2015 18:1756-1762  DOI:10.1038/nn.4162  PMID:26551544  PMCID:PMC4661126
    • Lukacs, V., Mathur, J., Mao, R., Bayrak-Toydemir, P., Procter, M., Cahalan, S. M., Kim, H. J., Bandell, M., Longo, N., Day, R. W., Stevenson, D. A., Patapoutian, A., et al. Impaired PIEZO1 function in patients with a novel autosomal recessive congenital lymphatic dysplasia Nature Communications  2015 6:8329  DOI:10.1038/ncomms9329  PMID:26387913  PMCID:PMC4578306
    • Syeda, R., Xu, J., Dubin, A. E., Coste, B., Mathur, J., Huynh, T., Matzen, J., Lao, J., Tully, D. C., Engels, I. H., Petrassi, H. M., Schumacher, A. M., et al. Chemical activation of the mechanotransduction channel Piezo1 Elife  2015 4:e07369  DOI:10.7554/eLife.07369  PMID:26001275  PMCID:PMC4456433
    • Cahalan, S. M., Lukacs, V., Ranade, S. S., Chien, S., Bandell, M., Patapoutian, A. Piezo1 links mechanical forces to red blood cell volume Elife  2015 4:e07370  DOI:10.7554/eLife.07370  PMID:26001274  PMCID:PMC4456639
    • Wieskopf, J. S., Mathur, J., Limapichat, W., Post, M. R., Al-Qazzaz, M., Sorge, R. E., Martin, L. J., Zaykin, D. V., Smith, S. B., Freitas, K., Austin, J. S., Dai, F., et al. The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors Science Translational Medicine  2015 7:287ra72  DOI:10.1126/scitranslmed.3009986  PMID:25972004  PMCID:PMC5018401
    • Coste, B., Murthy, S. E., Mathur, J., Schmidt, M., Mechioukhi, Y., Delmas, P., Patapoutian, A. Piezo1 ion channel pore properties are dictated by C-terminal region Nature Communications  2015 6:7223  DOI:10.1038/ncomms8223  PMID:26008989  PMCID:PMC4445471
    • Woo, S. H., Lumpkin, E. A., Patapoutian, A. Merkel cells and neurons keep in touch Trends in Cell Biology  2015 25:74-81  DOI:10.1016/j.tcb.2014.10.003  PMID:25480024  PMCID:PMC4312710
    • Ranade, S. S., Syeda, R., Patapoutian, A. Mechanically activated ion channels Neuron  2015 87:1162-1179  DOI:10.1016/j.neuron.2015.08.032  PMID:26402601  PMCID:PMC4582600
    • Ranade, S. S., Woo, S. H., Dubin, A. E., Moshourab, R. A., Wetzel, C., Petrus, M., Mathur, J., Begay, V., Coste, B., Mainquist, J., Wilson, A. J., Francisco, A. G., et al. Piezo2 is the major transducer of mechanical forces for touch sensation in mice Nature  2014 516:121-125  DOI:10.1038/nature13980  PMID:25471886  PMCID:PMC4380172
    • Ranade, S. S., Qiu, Z., Woo, S. H., Hur, S. S., Murthy, S. E., Cahalan, S. M., Xu, J., Mathur, J., Bandell, M., Coste, B., Li, Y. S. J., Chien, S., et al. Piezo1, a mechanically activated ion channel, is required for vascular development in mice Proceedings of the National Academy of Sciences of the United States of America  2014 111:10347-10352  DOI:10.1073/pnas.1409233111  PMID:24958852  PMCID:PMC4104881
    • Rooney, L., Vidal, A., D'Souza, A. M., Devereux, N., Masick, B., Boissel, V., West, R., Head, V., Stringer, R., Lao, J., Petrus, M. J., Patapoutian, A., et al. Discovery, optimization, and biological evaluation of 5-(2-(trifluoromethyl)phenyl)indazoles as a novel class of transient receptor potential A1 (TRPA1) antagonists Journal of Medicinal Chemistry  2014 57:5129-5140  DOI:10.1021/jm401986p  PMID:24884675
    • Maksimovic, S., Nakatani, M., Baba, Y., Nelson, A. M., Marshall, K. L., Wellnitz, S. A., Firozi, P., Woo, S. H., Ranade, S., Patapoutian, A., Lumpkin, E. A. Epidermal Merkel cells are mechanosensory cells that tune mammalian touch receptors Nature  2014 509:617-621  DOI:10.1038/nature13250  PMID:24717432  PMCID:PMC4097312
    • Woo, S. H., Ranade, S., Weyer, A. D., Dubin, A. E., Baba, Y., Qiu, Z., Petrus, M., Miyamoto, T., Reddy, K., Lumpkin, E. A., Stucky, C. L., Patapoutian, A. Piezo2 is required for Merkel-cell mechanotransduction Nature  2014 509:622-626  DOI:10.1038/nature13251  PMID:24717433  PMCID:PMC4039622
    • Qiu, Z., Dubin, A. E., Mathur, J., Tu, B., Reddy, K., Miraglia, L. J., Reinhardt, J., Orth, A. P., Patapoutian, A. SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel Cell  2014 157:447-458  DOI:10.1016/j.cell.2014.03.024  PMID:24725410  PMCID:PMC4023864
    • Kim, S. E., Patapoutian, A., Grandl, J. Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations PLoS One  2013 8:e59593  DOI:10.1371/journal.pone.0059593  PMID:23555720  PMCID:PMC3608658
    • Coste, B., Houge, G., Murray, M. F., Stitziel, N., Bandell, M., Giovanni, M. A., Philippakis, A., Hoischen, A., Riemer, G., Steen, U., Steen, V. M., Mathur, J., et al. Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis Proceedings of the National Academy of Sciences of the United States of America  2013 110:4667-4672  DOI:10.1073/pnas.1221400110  PMID:23487782  PMCID:PMC3607045
    • Coste, B., Patapoutian, A. Neuroscience: Salty sensations Nature  2013 494:44-45  DOI:10.1038/nature11946  PMID:23364688
    • Albuisson, J., Murthy, S. E., Bandell, M., Coste, B., Louis-dit-Picard, H., Mathur, J., Feneant-Thibault, M., Tertian, G., de Jaureguiberry, J. P., Syfuss, P. Y., Cahalan, S., Garcon, L., et al. Dehydrated hereditary stomatocytosis linked to gain-of-function mutations in mechanically activated PIEZO1 ion channels Nature Communications  2013 4:1884  DOI:10.1038/ncomms2899  PMID:23695678  PMCID:PMC3674779
    • Dubin, A. E., Schmidt, M., Mathur, J., Petrus, M. J., Xiao, B. L., Coste, B., Patapoutian, A. Inflammatory signals enhance piezo2-mediated mechanosensitive currents Cell Reports  2012 2:511-517  DOI:10.1016/j.celrep.2012.07.014  PMID:22921401  PMCID:PMC3462303
    • Bandell, M., Patapoutian, A. A hot new channel Nature Neuroscience  2012 15:931-933  DOI:10.1038/nn.3148  PMID:22735512
    • Coste, B., Xiao, B. L., Santos, J. S., Syeda, R., Grandl, J., Spencer, K. S., Kim, S. E., Schmidt, M., Mathur, J., Dubin, A. E., Montal, M., Patapoutian, A. Piezo proteins are pore-forming subunits of mechanically activated channels Nature  2012 483:176-181  DOI:10.1038/nature10812  PMID:22343900  PMCID:PMC3297710
    • Kim, S. E., Coste, B., Chadha, A., Cook, B., Patapoutian, A. The role of Drosophila Piezo in mechanical nociception Nature  2012 483:209-212  DOI:10.1038/nature10801  PMID:22343891  PMCID:PMC3297676
    • Blasius, A. L., Dubin, A. E., Petrus, M. J., Lim, B. K., Narezkina, A., Criado, J. R., Wills, D. N., Xia, Y., Moresco, E. M. Y., Ehlers, C., Knowlton, K. U., Patapoutian, A., et al. Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype Proceedings of the National Academy of Sciences of the United States of America  2011 108:19413-19418  DOI:10.1073/pnas.1117020108  PMID:22087007  PMCID:PMC3228463
    • Miyamoto, T., Patapoutian, A. Why does morphine make you itch? Cell  2011 147:261-262  DOI:10.1016/j.cell.2011.09.026  PMID:22000005
    • Miyamoto, T., Petrus, M. J., Dubin, A. E., Patapoutian, A. TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin Nature Communications  2011 2:369  DOI:10.1038/ncomms1371  PMID:21712817  PMCID:PMC3320851
    • Xiao, B. L., Coste, B., Mathur, J., Patapoutian, A. Temperature-dependent STIM1 activation induces Ca(2+) influx and modulates gene expression Nature Chemical Biology  2011 7:351-358  DOI:10.1038/nchembio.558  PMID:21499266  PMCID:PMC3097298
    • Xiao, B. L., Patapoutian, A. Scratching the surface: A role of pain-sensing TRPA1 in itch Nature Neuroscience  2011 14:540-542  DOI:10.1038/nn.2813  PMID:21522144
    • del Camino, D., Murphy, S., Heiry, M., Barrett, L. B., Earley, T. J., Cook, C. A., Petrus, M. J., Zhao, M., D'Amours, M., Deering, N., Brenner, G. J., Costigan, M., et al. TRPA1 contributes to cold hypersensitivity Journal of Neuroscience  2010 30:15165-15174  DOI:10.1523/jneurosci.2580-10.2010  PMID:21068322  PMCID:PMC3021322
    • Dubin, A. E., Patapoutian, A. Nociceptors: The sensors of the pain pathway Journal of Clinical Investigation  2010 120:3760-3772  DOI:10.1172/jci42843  PMID:21041958  PMCID:PMC2964977
    • Coste, B., Mathur, J., Schmidt, M., Earley, T. J., Ranade, S., Petrus, M. J., Dubin, A. E., Patapoutian, A. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels Science  2010 330:55-60  DOI:10.1126/science.1193270  PMID:20813920  PMCID:PMC3062430
    • Grandl, J., Kim, S. E., Uzzell, V., Bursulaya, B., Petrus, M., Bandell, M., Patapoutian, A. Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain Nature Neuroscience  2010 13:708-714  DOI:10.1038/nn.2552  PMID:20414199  PMCID:PMC2876202
    • Macpherson, L. J., Patapoutian, A. Channels: Flies feel your pain Nature Chemical Biology  2010 6:252-253  DOI:10.1038/nchembio.339  PMID:20300095
    • Bandell, M., Patapoutian, A. Itching for insight Cell  2009 139:1224-1226  DOI:10.1016/j.cell.2009.12.012  PMID:20064368
    • Schmidt, M., Dubin, A. E., Petrus, M. J., Earley, T. J., Patapoutian, A. Nociceptive signals induce trafficking of TRPA1 to the plasma membrane Neuron  2009 64:498-509  DOI:10.1016/j.neuron.2009.09.030  PMID:19945392  PMCID:PMC2854037
    • Miyamoto, T., Dubin, A. E., Petrus, M. J., Patapoutian, A. TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice PLoS One  2009 4:e7596  DOI:10.1371/journal.pone.0007596  PMID:19893614  PMCID:PMC2764051
    • Mandadi, S., Sokabe, T., Shibasaki, K., Katanosaka, K., Mizuno, A., Moqrich, A., Patapoutian, A., Fukumi-Tominaga, T., Mizumura, K., Tominaga, M. TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP Pflugers Archiv-European Journal of Physiology  2009 458:1093-1102  DOI:10.1007/s00424-009-0703-x  PMID:19669158  PMCID:PMC2745623
    • Mandadi, S., Nakanishi, S. T., Takashima, Y., Dhaka, A., Patapoutian, A., McKemy, D. D., Whelan, P. J. Locomotor networks are targets of modulation by sensory transient receptor potential vanilloid 1 and transient receptor potential melastatin 8 channels Neuroscience  2009 162:1377-1397  DOI:10.1016/j.neuroscience.2009.05.063  PMID:19482068  PMCID:PMC2880570
    • Hu, H. Z., Bandell, M., Petrus, M. J., Zhu, M. X., Patapoutian, A. Zinc activates damage-sensing TRPA1 ion channels Nature Chemical Biology  2009 5:183-190  DOI:10.1038/nchembio.146  PMID:19202543  PMCID:PMC2677965
    • Hu, H. Z., Grandl, J., Bandell, M., Petrus, M., Patapoutian, A. Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4 Proceedings of the National Academy of Sciences of the United States of America  2009 106:1626-1631  DOI:10.1073/pnas.0812209106  PMID:19164517  PMCID:PMC2635798
    • Dhaka, A., Uzzell, V., Dubin, A. E., Mathur, J., Petrus, M., Bandell, M., Patapoutian, A. TRPV1 is activated by both acidic and basic pH Journal of Neuroscience  2009 29:153-158  DOI:10.1523/jneurosci.4901-08.2009  PMID:19129393  PMCID:PMC2729567
    • Patapoutian, A., Tate, S., Woolf, C. J. Transient receptor potential channels: Targeting pain at the source Nature Reviews Drug Discovery  2009 8:55-68  DOI:10.1038/nrd2757  PMID:19116627  PMCID:PMC2755576
    • Xiao, B., Dubin, A. E., Bursulaya, B., Viswanath, V., Jegla, T. J., Patapoutian, A. Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels Journal of Neuroscience  2008 28:9640-9651  DOI:10.1523/jneurosci.2772-08.2008  PMID:18815250  PMCID:PMC2678945
    • Grandl, J., Hu, H. Z., Bandell, M., Bursulaya, B., Schmidt, M., Petrus, M., Patapoutian, A. Pore region of TRPV3 ion channel is specifically required for heat activation Nature Neuroscience  2008 11:1007-1013  DOI:10.1038/nn.2169  PMID:19160498  PMCID:PMC2685190
    • Dhaka, A., Earley, T. J., Watson, J., Patapoutian, A. Visualizing cold spots: TRPM8-expressing sensory neurons and their projections Journal of Neuroscience  2008 28:566-575  DOI:10.1523/jneurosci.3976-07.2008  PMID:18199758
    • Petrus, M., Peier, A. M., Bandell, M., Hwang, S. W., Huynh, T., Olney, N., Jegla, T., Patapoutian, A. A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition Molecular Pain  2007 3:40  DOI:10.1186/1744-8069-3-40  PMID:18086313  PMCID:PMC2222610
    • Macpherson, L. J., Xiao, B., Kwan, K. Y., Petrus, M. J., Dubin, A. E., Hwang, S., Cravatt, B., Corey, D. P., Patapoutian, A. An ion channel essential for sensing chemical damage Journal of Neuroscience  2007 27:11412-11415  DOI:10.1523/jneurosci.3600-07.2007  PMID:17942735
    • Bandell, M., Macpherson, L. J., Patapoutian, A. From chills to chilis: Mechanisms for thermosensation and chemesthesis via thermoTRPs Current Opinion in Neurobiology  2007 17:490-497  DOI:10.1016/j.conb.2007.07.014  PMID:17706410  PMCID:PMC2080617
    • Dhaka, A., Murray, A. N., Mathur, J., Earley, T. J., Petrus, M. J., Patapoutian, A. TRPM8 is required for cold sensation in mice Neuron  2007 54:371-378  DOI:10.1016/j.neuron.2007.02.024  PMID:17481391
    • Kindt, K. S., Viswanath, V., Macpherson, L., Quast, K., Hu, H. Z., Patapoutian, A., Schafer, W. R. Caenorhabditis elegans TRPA-1 functions in mechanosensation Nature Neuroscience  2007 10:568-577  DOI:10.1038/nn1886  PMID:17450139
    • Macpherson, L. J., Dubin, A. E., Evans, M. J., Marr, F., Schultz, P. G., Cravatt, B. F., Patapoutian, A. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines Nature  2007 445:541-545  DOI:10.1038/nature05544  PMID:17237762
    • McCleverty, C. J., Koesema, E., Patapoutian, A., Lesley, S. A., Kreusch, A. Crystal structure of the human TRPV2 channel ankyrin repeat domain Protein Science  2006 15:2201-2206  DOI:10.1110/ps.062357206  PMID:16882997  PMCID:PMC2242602
    • Saghatelian, A., McKinney, M. K., Bandell, M., Patapoutian, A., Cravatt, B. F. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels Biochemistry  2006 45:9007-9015  DOI:10.1021/bi0608008  PMID:16866345
    • Macpherson, L. J., Hwang, S. W., Miyamoto, T., Dubin, A. E., Patapoutian, A., Story, G. M. More than cool: promiscuous relationships of menthol and other sensory compounds Molecular and Cellular Neuroscience  2006 32:335-343  DOI:10.1016/j.mcn.2006.05.005  PMID:16829128
    • Patapoutian, A.*, Macpherson, L.* Channeling pain Nature Medicine  2006 12:506-507  DOI:10.1038/nm0506-506  PMID:16675993 (* = equal contribution)
    • Bandell, M., Dubin, A. E., Petrus, M. J., Orth, A., Mathur, J., Hwang, S. W., Patapoutian, A. High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol Nature Neuroscience  2006 9:493-500  DOI:10.1038/nn1665  PMID:16520735
    • Dhaka, A., Viswanath, V., Patapoutian, A. TRP ion channels and temperature sensation Annual Review of Neuroscience  2006 29:135-161  DOI:10.1146/annurev.neuro.29.051605.112958  PMID:16776582
    • Macpherson, L. J., Geierstanger, B. H., Viswanath, V., Bandell, M., Eid, S. R., Hwang, S., Patapoutian, A. The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin Current Biology  2005 15:929-934  DOI:10.1016/j/cub.2005.04.018  PMID:15916949
    • Moqrich, A., Hwang, S. W., Earley, T. J., Petrus, M. J., Murray, A. N., Spencer, K. S. R., Andahazy, M., Story, G. M., Patapoutian, A. Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin Science  2005 307:1468-1472  DOI:10.1126/science.1108609  PMID:15746429
    • Rosenzweig, M., Brennan, K. M., Tayler, T. D., Phelps, P. O., Patapoutian, A., Garrity, P. A. The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis Genes & Development  2005 19:419-424  DOI:10.1101/gad.1278205  PMID:15681611  PMCID:PMC548941
    • Patapoutian, A. TRP channels and thermosensation Chemical Senses  2005 30:i193-i194  DOI:10.1093/chemse/bjh180  PMID:15738110
    • Patapoutian, A., Wood, J. N. Mechanisms of nociception: molecules to behaviour Journal of Neurobiology  2004 61:1-2  DOI:10.1002/neu.20092
    • Moqrich, A., Earley, T. J., Watson, J., Andahazy, M., Backus, C., Martin-Zanca, D., Wright, D. E., Reichardt, L. F., Patapoutian, A. Expressing TrkC from the TrkA locus causes a subset of dorsal root ganglia neurons to switch fate Nature Neuroscience  2004 7:812-818  DOI:10.1038/nn1283  PMID:15247919  PMCID:PMC2693051
    • Bandell, M., Story, G. M., Hwang, S. W., Viswanath, V., Eid, S. R., Petrus, M. J., Earley, T. J., Patapoutian, A. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin Neuron  2004 41:849-857  DOI:10.1016/s0896-6273(04)00150-3  PMID:15046718
    • Viswanath, V., Story, G. M., Peier, A. M., Petrus, M. J., Hwang, S. W., Patapoutian, A., Jegla, T. Ion channels: Opposite thermosensor in fruitfly and mouse Nature  2003 423:822-823  DOI:10.1038/423822a  PMID:12815418
    • Story, G. M., Peier, A. M., Reeve, A. J., Eid, S. R., Mosbacher, J., Hricik, T. R., Earley, T. J., Hergarden, A. C., Andersson, D. A., Hwang, S. W., McIntyre, P., Jegla, T., et al. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures Cell  2003 112:819-829  DOI:10.1016/s0092-8674(03)00158-2  PMID:12654248
    • Patapoutian, A., Peier, A. M., Story, G. M., Viswanath, V. ThermoTRP channels and beyond: Mechanisms of temperature sensation Nature Reviews Neuroscience  2003 4:529-539  DOI:10.1038/nrn1141  PMID:12838328
    • Peier, A. M., Reeve, A. J., Andersson, D. A., Moqrich, A., Earley, T. J., Hergarden, A. C., Story, G. M., Colley, S., Hogenesch, J. B., McIntyre, P., Bevan, S., Patapoutian, A. A heat-sensitive TRP channel expressed in keratinocytes Science  2002 296:2046-2049  DOI:10.1126/science.1073140  PMID:12016205
    • Su, A. I., Cooke, M. P., Ching, K. A., Hakak, Y., Walker, J. R., Wiltshire, T., Orth, A. P., Vega, R. G., Sapinoso, L. M., Moqrich, A., Patapoutian, A., Hampton, G. M., et al. Large-scale analysis of the human and mouse transcriptomes Proceedings of the National Academy of Sciences of the United States of America  2002 99:4465-4470  DOI:10.1073/pnas.012025199  PMID:11904358  PMCID:PMC123671
    • Peier, A. M., Moqrich, A., Hergarden, A. C., Reeve, A. J., Andersson, D. A., Story, G. M., Earley, T. J., Dragoni, I., McIntyre, P., Bevan, S., Patapoutian, A. A TRP channel that senses cold stimuli and menthol Cell  2002 108:705-715  DOI:10.1016/s0092-8674(02)00652-9  PMID:11893340
    • Patapoutian, A. Making the pain connection Neuron  2001 31:4-6  DOI:10.1016/s0896-6273(01)00352-x  PMID:11498043
    • Patapoutian, A., Reichardt, L. F. Trk receptors: mediators of neurotrophin action Current Opinion in Neurobiology  2001 11:272-280  DOI:10.1016/s0959-4388(00)00208-7  PMID:11399424
    • Patapoutian, A., Reichardt, L. F. Roles of Wnt proteins in neural development and maintenance Current Opinion in Neurobiology  2000 10:392-399  DOI:10.1016/s0959-4388(00)00100-8  PMID:10851180
    • Patapoutian, A., Backus, C., Kispert, A., Reichardt, L. F. Regulation of neurotrophin-3 expression by epithelial mesenchymal interactions: the role of Wnt factors Science  1999 283:1180-1183  DOI:10.1126/science.283.5405.1180  PMID:10024246  PMCID:PMC2710127
    • Farinas, I., Wilkinson, G. A., Backus, C., Reichardt, L. F., Patapoutian, A. Characterization of neurotrophin and Trk receptor functions in developing sensory ganglia: direct NT-3 activation of TrkB neurons in vivo Neuron  1998 21:325-334  DOI:10.1016/s0896-6273(00)80542-5  PMID:9728914  PMCID:PMC2711510
    • Patapoutian, A., Wold, B. J., Wagner, R. A. Evidence for developmentally programmed transdifferentiation in mouse esophageal muscle Science  1995 270:1818-1821  DOI:10.1126/science.270.5243.1818  PMID:8525375
    • Patapoutian, A., Yoon, J. K., Miner, J. H., Wang, S. L., Stark, K., Wold, B. Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome Development  1995 121:3347-3358  PMID:7588068
    • Patapoutian, A., Miner, J. H., Lyons, G. E., Wold, B. Isolated sequences from the linked Myf-5 and MRF4 genes drive distinct patterns of muscle-specific expression in transgenic mice Development  1993 118:61-69  PMID:8375340
    • Verma, R., Patapoutian, A., Gordon, C. B., Campbell, J. L. Identification and purification of a factor that binds to the Mlu I cell cycle box of yeast DNA replication genes Proceedings of the National Academy of Sciences of the United States of America  1991 88:7155-7159  DOI:10.1073/pnas.88.16.7155  PMID:1871128  PMCID:PMC52252
    • Pignoni, F., Baldarelli, R. M., Steingrimsson, E., Diaz, R. J., Patapoutian, A., Merriam, J. R., Lengyel, J. A. The Drosophila gene tailless is expressed at the embryonic termini and is a member of the steroid receptor superfamily Cell  1990 62:151-163  DOI:10.1016/0092-8674(90)90249-e  PMID:2364433

featured in

  • HHMI Selects 27 of the Nation’s Top Biomedical Scientists  News Release
  • Scripps Research Institute Dedicates Dorris Neuroscience Center  News Release
  • Scripps Research Scientists Discover New Molecular Pathway Involved in Wound Healing and Temperature Sensation  News Release
  • Scripps Research Scientists Identify Protein that Sends ‘Painful Touch’ Signals  News Release
  • Team Solves Decades-Old Mystery of How Cells Keep from Bursting  News Release
  • The Scripps Research Institute’s Ardem Patapoutian Named HHMI Investigator  News Release
  • Work of Four TSRI Scientists Contribute in Science Magazine's Top-Ten Breakthroughs of Year  Newsletter
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Research

research overview

  • The sense of touch consists of the perception of discrete types of thermal, mechanical, and chemical stimuli. However, little is known about the molecular basis of touch perception. Our lab is characterizing the genes involved in the first step of touch sensation: those that encode the molecular sensors of touch stimuli. With the completion of the human genome project, we have powerful new methods to identify these elusive sensory molecules. We recently identified the first gene involved in our ability to sense cold temperatures. This gene, trpm8, encodes for a protein present at the plasma membrane of cold-sensing neurons that belongs to the Transient Receptor Potential (TRP) channel family. Interestingly, TRPM8 is also activated by menthol, a commonly-used cooling compound. We are continuing to identify additional sensory receptors, and working towards understanding the mechanism of activation of these channels. Another direction in the lab is to understand how these sensory neurons become specialized during development. We are using transgenic and genomic technologies to address these questions.
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Teaching

advisees

  • graduate advising relationship

    • Wang, Yu, Ph.D.  candidate, 2018 -
    • Kefauver, Jennifer, Ph.D.  candidate, 2013 - 2018
    • Kim, Sung Eun, Ph.D.  candidate, 2009 - 2013
    • Ranade, Sanjeev, Ph.D.  candidate, 2007 - 2013
    • Miyamoto, Takashi, Ph.D.  candidate, 2005 - 2011
    • Macpherson, Lindsey, Ph.D.  candidate, 2004 - 2007
  • postdoc or fellow advising relationship

    • Cahalan, Stuart Morgan, Ph.D.  candidate, 2011 - 2016
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Background

education and training

  • Ph.D. in Biology, California Institute of Technology , with Dr. Barbara Wold 1990 - 1996
  • B.S. in Molecular, Cellular & Development Biology, University of California, Los Angeles , magna cum laude, with Dr. Judy A. Lengyel 1987 - 1990

awards and honors

  • Lewis S. Rosenstiel Award, 2019
  • Fellowship of the American Association for the Advancement of Science, 2016
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Contact

full name

  • Ardem S. Patapoutian

geographic location

  • Scripps California 

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