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Parsons, Loren (Larry)
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Parsons, Loren (Larry)

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Positions

  • 2010 - 2016 Associate Professor, Committee on the Neurobiology of Addictive Disorders (CNAD) , Scripps Research
  • 1998 - 2016 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2003 - 2009 Associate Professor, Committee on the Neurobiology of Addictive Disorders (CNAD) , Scripps Research
  • 1998 - 2003 Assistant Professor, Neuropharmacology , Scripps Research
  • 1995 - 1998 Senior Research Associate, Neuropharmacology , Scripps Research
  • 1992 - 1995 Postdoctoral Fellow, Neuropharmacology , Scripps Research
Dr. Loren Parsons studies neurochemical mechanisms in drug dependence with the goal of characterizing neural pathologies that may be viable targets for a pharmacotherapy of addiction; particular focus is on the central serotonin and endocannabinoid systems.

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  • Mental Illness (UMLS)
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Publications

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    • Agoglia, A. E., Zhu, M., Ying, R., Sidhu, H., Natividad, L. A., Wolfe, S. A., Buczynski, M. W., Contet, C., Parsons, L. H., Roberto, M., Herman, M. A. Corticotropin-releasing factor receptor-1 neurons in the lateral amygdala display selective sensitivity to acute and chronic ethanol exposure Eneuro  2020 7  DOI:10.1523/eneuro.0420-19.2020  PMID:32041742  PMCID:PMC7059189
    • Pavon, F. J., Polis, I., Stouffer, D. G., Roberto, M., Martin-Fardon, R., de Fonseca, F. R., Parsons, L. H., Serrano, A. COX-2 Inhibition Antagonizes Intra-Accumbens 2-Arachidonoylglycerol-Mediated Reduction in Ethanol Self-Administration in Rats Alcoholism-Clinical and Experimental Research  2020  DOI:10.1111/acer.14456  PMID:32944989
    • Pavon, F. J., Serrano, A., Stouffer, D. G., Polis, I., Roberto, M., Cravatt, B. F., Martin-Fardon, R., de Fonseca, F. R., Parsons, L. H. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice Addiction Biology  2019 24:1204-1215  DOI:10.1111/adb.12695  PMID:30421483  PMCID:PMC6551299
    • Moreno, M., Decara, J., Pavon, F. J., Stouffer, D. G., Edwards, S., Serrano, A., Suarez, J., Parsons, L. H., de Fonseca, F. R. Cannabinoid dependence induces sustained changes in GABA release in the globus pallidus without affecting dopamine release in the dorsal striatum: A dual microdialysis probe study Addiction Biology  2018 23:1251-1261  DOI:10.1111/adb.12694  PMID:30421559
    • Berger, A. L., Henricks, A. M., Lugo, J. M., Wright, H. R., Warrick, C. R., Sticht, M. A., Morena, M., Bonilla, I., Laredo, S. A., Craft, R. M., Parsons, L. H., Grandes, P. R., et al. The lateral habenula directs coping styles under conditions of stress via recruitment of the endocannabinoid system Biological Psychiatry  2018 84:611-623  DOI:10.1016/j.biopsych.2018.04.018  PMID:29887035  PMCID:PMC6162143
    • Natividad, L. A., Steinman, M. Q., Laredo, S. A., Irimia, C., Polis, I. Y., Lintz, R., Buczynski, M. W., Martin-Fardon, R., Roberto, M., Parsons, L. H. Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility Addiction Biology  2018 23:1117-1129  DOI:10.1111/adb.12568  PMID:28940879  PMCID:PMC5862723
    • Gonzalez-Cuevas, G., Martin-Fardon, R., Kerr, T. M., Stouffer, D. G., Parsons, L. H., Hammell, D. C., Banks, S. L., Stinchcomb, A. L., Weiss, F. Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle Neuropsychopharmacology  2018 43:2036-2045  DOI:10.1038/s41386-018-0050-8  PMID:29686308  PMCID:PMC6098033
    • Serrano, A., Pavon, F. J., Buczynski, M. W., Schlosburg, J., Natividad, L. A., Polis, I. Y., Stouffer, D. G., Zorrilla, E. P., Roberto, M., Cravatt, B. F., Martin-Fardon, R., de Fonseca, F. R., et al. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake Neuropsychopharmacology  2018 43:1840-1850  DOI:10.1038/s41386-018-0055-3  PMID:29748627  PMCID:PMC6046053
    • Kirson, D., Oleata, C. S., Parsons, L. H., Ciccocioppo, R., Roberto, M. CB1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats Addiction Biology  2018 23:676-688  DOI:10.1111/adb.12525  PMID:28656627  PMCID:PMC5745318
    • Pavon, F. J., Serrano, A., Sidhpura, N., Polis, I., Stouffer, D., de Fonseca, F. R., Cravatt, B. F., Martin-Fardon, R., Parsons, L. H. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens Addiction Biology  2018 23:723-734  DOI:10.1111/adb.12531  PMID:28660730  PMCID:PMC5747548
    • Natividad, L. A., Buczynski, M. W., Herman, M. A., Kirson, D., Oleata, C. S., Irimia, C., Polis, I., Ciccocioppo, R., Roberto, M., Parsons, L. H. Constitutive increases in amygdalar corticotropin-releasing factor and fatty acid amide hydrolase drive an anxious phenotype Biological Psychiatry  2017 82:500-510  DOI:10.1016/j.biopsych.2017.01.005  PMID:28209423  PMCID:PMC5509512
    • Formisano, S., Hornig, M., Yaddanapudi, K., Vasishtha, M., Parsons, L. H., Briese, T., Lipkin, W. I., Williams, B. L. Central nervous system infection with Borna disease virus causes kynurenine pathway dysregulation and neurotoxic quinolinic acid production Journal of Virology  2017 91:e00673-17  DOI:10.1128/jvi.00673-17  PMID:28446679  PMCID:PMC5487560
    • Irimia, C., Buczynski, M. W., Natividad, L. A., Laredo, S. A., Avalos, N., Parsons, L. H. Dysregulated glycine signaling contributes to increased impulsivity during protracted alcohol abstinence Journal of Neuroscience  2017 37:1853-1861  DOI:10.1523/jneurosci.2466-16.2017  PMID:28202787  PMCID:PMC5320613
    • Nguyen, J. D., Aarde, S. M., Vandewater, S. A., Grant, Y., Stouffer, D. G., Parsons, L. H., Cole, M., Taffe, M. A. Inhaled delivery of Δ(9)-tetrahydrocannabinol (THC) to rats by e-cigarette vapor technology Neuropharmacology  2016 109:112-120  DOI:10.1016/j.neuropharm.2016.05.021  PMID:27256501  PMCID:PMC4970926
    • Souza-Smith, F. M., Lang, C. H., Nagy, L. E., Bailey, S. M., Parsons, L. H., Murray, G. J. Physiological processes underlying organ injury in alcohol abuse American Journal of Physiology-Endocrinology and Metabolism  2016 311:E605-E619  DOI:10.1152/ajpendo.00270.2016  PMID:27436613
    • Varodayan, F. P., Soni, N., Bajo, M., Luu, G., Madamba, S. G., Schweitzer, P., Parsons, L. H., Roberto, M. Chronic ethanol exposure decreases CB1 receptor function at GABAergic synapses in the rat central amygdala Addiction Biology  2016 21:788-801  DOI:10.1111/adb.12256  PMID:25940135  PMCID:PMC4635109
    • Bilbao, A., Serrano, A., Cippitelli, A., Pavon, F. J., Giuffrida, A., Suarez, J., Garcia-Marchena, N., Baixeras, E., Gómez de Heras, R., Orio, L., Alen, F., Ciccocioppo, R., et al. Role of the satiety factor oleoylethanolamide in alcoholism Addiction Biology  2016 21:859-872  DOI:10.1111/adb.12276  PMID:26037332  PMCID:PMC4668242
    • Curran, H. V., Freeman, T. P., Mokrysz, C., Lewis, D. A., Morgan, C. J. A., Parsons, L. H. Keep off the grass? Cannabis, cognition and addiction Nature Reviews Neuroscience  2016 17:293-306  DOI:10.1038/nrn.2016.28  PMID:27052382
    • Buczynski, M. W., Herman, M. A., Hsu, K. L., Natividad, L. A., Irimia, C., Polis, I. Y., Pugh, H., Chang, J. W., Niphakis, M. J., Cravatt, B. F., Roberto, M., Parsons, L. H. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure Proceedings of the National Academy of Sciences of the United States of America  2016 113:1086-1091  DOI:10.1073/pnas.1522672113  PMID:26755579  PMCID:PMC4743781
    • De Luca, M. A., Bimpisidis, Z., Melis, M., Marti, M., Caboni, P., Valentini, V., Margiani, G., Pintori, N., Polis, I., Marsicano, G., Parsons, L. H., Di Chiara, G. Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid Neuropharmacology  2015 99:705-714  DOI:10.1016/j.neuropharm.2015.08.041  PMID:26327678
    • Parsons, L. H., Hurd, Y. L. Endocannabinoid signalling in reward and addiction Nature Reviews Neuroscience  2015 16:579-594  DOI:10.1038/nrn4004  PMID:26373473  PMCID:PMC4652927
    • Liu, J., Parsons, L., Pope, C. Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum Neurotoxicology  2015 50:20-27  DOI:10.1016/j.neuro.2015.07.006  PMID:26215119  PMCID:PMC4767275
    • Irimia, C., Polis, I. Y., Stouffer, D., Parsons, L. H. Persistent effects of chronic Δ9-THC exposure on motor impulsivity in rats Psychopharmacology  2015 232:3033-3043  DOI:10.1007/s00213-015-3942-x  PMID:25925779
    • Herman, M. A., Sidhu, H., Stouffer, D. G., Kreifeldt, M., Le, D., Cates-Gatto, C., Munoz, M. B., Roberts, A. J., Parsons, L. H., Roberto, M., Wickman, K., Slesinger, P. A., et al. GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol Proceedings of the National Academy of Sciences of the United States of America  2015 112:7091-7096  DOI:10.1073/pnas.1416146112  PMID:25964320  PMCID:PMC4460485
    • Irimia, C., Wiskerke, J., Natividad, L. A., Polis, I. Y., de Vries, T. J., Pattij, T., Parsons, L. H. Increased impulsivity in rats as a result of repeated cycles of alcohol intoxication and abstinence Addiction Biology  2015 20:263-274  DOI:10.1111/adb.12119  PMID:24341858  PMCID:PMC4061283
    • Irimia, C., Tuong, R. N., Quach, T., Parsons, L. H. Impaired response inhibition in the rat 5 choice continuous performance task during protracted abstinence from chronic alcohol consumption PLoS One  2014 9:e109948  DOI:10.1371/journal.pone.0109948  PMID:25333392  PMCID:PMC4198178
    • Gonzalez-Aparicio, R., Blanco, E., Serrano, A., Pavon, F. J., Parsons, L. H., Maldonado, R., Robledo, P., Fernandez-Espejo, E., de Fonseca, F. R. The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism International Journal of Neuropsychopharmacology  2014 17:455-468  DOI:10.1017/s1461145713001259  PMID:24169105
    • Liu, J., Parsons, L., Pope, C. Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels in rat hippocampus: Influence on cholinergic toxicity Toxicology and Applied Pharmacology  2013 272:608-615  DOI:10.1016/j.taap.2013.07.025  PMID:23933531  PMCID:PMC3831619
    • Niphakis, M. J., Cognetta III, A. B., Chang, J. W., Buczynski, M. W., Parsons, L. H., Byrne, F., Burston, J. J., Chapman, V., Cravatt, B. F. Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors ACS Chemical Neuroscience  2013 4:1322-1332  DOI:10.1021/cn400116z  PMID:23731016  PMCID:PMC3778430
    • Talantova, M., Sanz-Blasco, S., Zhang, X. F., Xia, P., Akhtar, M. W., Okamoto, S., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., Kang, Y. J., Tu, S., et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss Proceedings of the National Academy of Sciences of the United States of America  2013 110:E2518-E2527  DOI:10.1073/pnas.1306832110  PMID:23776240  PMCID:PMC3704025
    • Wright, M. J., Vandewater, S. A., Parsons, L. H., Taffe, M. A. delta(9)Tetrahydrocannabinol impairs reversal learning but not extra-dimensional shifts in rhesus macaques Neuroscience  2013 235:51-58  DOI:10.1016/j.neuroscience.2013.01.018  PMID:23333671  PMCID:PMC3595391
    • Muldoon, P. P., Lichtman, A. H., Parsons, L. H., Damaj, M. I. The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence Life Sciences  2013 92:458-462  DOI:10.1016/j.lfs.2012.05.015  PMID:22705310  PMCID:PMC3477273
    • Buczynski, M. W., Polis, I. Y., Parsons, L. H. The volitional nature of nicotine exposure alters anandamide and oleoylethanolamide levels in the ventral tegmental area Neuropsychopharmacology  2013 38:574-584  DOI:10.1038/npp.2012.210  PMID:23169348  PMCID:PMC3572454
    • Natividad, L. A., Buczynski, M. W., Parsons, L. H., Torres, O. V., O'Dell, L. E. Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal Journal of Neurochemistry  2012 123:578-588  DOI:10.1111/j.1471-4159.2012.07926.x  PMID:22905672  PMCID:PMC3472122
    • Wright, M. J., Angrish, D., Aarde, S. M., Barlow, D. J., Buczynski, M. W., Creehan, K. M., Vandewater, S. A., Parsons, L. H., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats PLoS One  2012 7:e44652  DOI:10.1371/journal.pone.0044652  PMID:22952999  PMCID:PMC3432134
    • Serrano, A., Rivera, P., Pavon, F. J., Decara, J., Suarez, J., de Fonseca, F. R., Parsons, L. H. Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala Alcoholism-Clinical and Experimental Research  2012 36:984-994  DOI:10.1111/j.1530-0277.2011.01686.x  PMID:22141465  PMCID:PMC3297719
    • Chang, J. W., Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Wang, C., Matthews, M. L., Niessen, S., Buczynski, M. W., Parsons, L. H., Cravatt, B. F. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates Chemistry & Biology  2012 19:579-588  DOI:10.1016/j.chembiol.2012.03.009  PMID:22542104  PMCID:PMC3361572
    • Serrano, A., Parsons, L. H. Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors Pharmacology & Therapeutics  2011 132:215-241  DOI:10.1016/j.pharmthera.2011.06.005  PMID:21798285  PMCID:PMC3209522
    • Sidhpura, N., Parsons, L. H. Endocannabinoid-mediated synaptic plasticity and addiction-related behavior Neuropharmacology  2011 61:1070-1087  DOI:10.1016/j.neuropharm.2011.05.034  PMID:21669214  PMCID:PMC3176941
    • Ramchandani, V. A., Umhau, J., Pavon, F. J., Ruiz-Velasco, V., Margas, W., Sun, H., Damadzic, R., Eskay, R., Schoor, M., Thorsell, A., Schwandt, M. L., Sommer, W. H., et al. A genetic determinant of the striatal dopamine response to alcohol in men Molecular Psychiatry  2011 16:809-817  DOI:10.1038/mp.2010.56  PMID:20479755  PMCID:PMC2925052
    • Pope, C., Mechoulam, R., Parsons, L. Endocannabinoid signaling in neurotoxicity and neuroprotection Neurotoxicology  2010 31:562-571  DOI:10.1016/j.neuro.2009.12.002  PMID:19969019  PMCID:PMC2891218
    • Huitron-Resendiz, S., Henriksen, S. J., Barr, M. C., Testa, M. P., Crawford, E., Parsons, L. H., Sanchez-Alavez, M., Phillips, T. R. Methamphetamine and lentivirus interactions: reciprocal enhancement of central nervous system disease Journal of Neurovirology  2010 16:268-278  DOI:10.3109/13550284.2010.497807  PMID:20608774
    • Roberto, M., Cruz, M., Bajo, M., Siggins, G. R., Parsons, L. H., Schweitzer, P. The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala Neuropsychopharmacology  2010 35:1962-1972  DOI:10.1038/npp.2010.70  PMID:20463657  PMCID:PMC2904853
    • Buczynski, M. W., Parsons, L. H. Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls British Journal of Pharmacology  2010 160:423-442  DOI:10.1111/j.1476-5381.2010.00787.x  PMID:20590555  PMCID:PMC2931546
    • Roberto, M., Cruz, M. T., Gilpin, N. W., Sabin, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., et al. Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence Biological Psychiatry  2010 67:831-839  DOI:10.1016/j.biopsych.2009.11.007  PMID:20060104  PMCID:PMC2883449
    • Plaza-Zabala, A., Berrendero, F., Suarez, J., Bermudez-Silva, F. J., Fernandez-Espejo, E., Serrano, A., Pavon, F. J., Parsons, L. H., De Fonseca, F. R., Maldonado, R., Robledo, P. Effects of the endogenous PPAR-alpha agonist, oleoylethanolamide on MDMA-induced cognitive deficits in mice Synapse  2010 64:379-389  DOI:10.1002/syn.20733  PMID:20029832
    • Villanueva, A., Yilmaz, S. M., Millington, W. R., Cutrera, R. A., Stouffer, D. G., Parsons, L. H., Cheer, J. F., Feleder, C. Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area Shock  2009 32:614-620  DOI:10.1097/SHK.0b013e3181a4fd8f  PMID:19295473
    • Qu, Y., Saint Marie, R., Breier, M. R., Ko, D., Stouffer, D., Parsons, L. H., Swerdlow, N. R. Neural basis for a heritable phenotype: differences in the effects of apomorphine on startle gating and ventral pallidal GABA efflux in male Sprague-Dawley and Long-Evans rats Psychopharmacology  2009 207:271-280  DOI:10.1007/s00213-009-1654-9  PMID:19756524  PMCID:PMC2770636
    • Neumaier, J. F., McDevitt, R. A., Polis, I. Y., Parsons, L. H. Acquisition of and withdrawal from cocaine self-administration regulates 5-HT(1B) mRNA expression in rat striatum Journal of Neurochemistry  2009 111:217-227  DOI:10.1111/j.1471-4159.2009.06313.x  PMID:19659573
    • Alvarez-Jaimes, L., Stouffer, D. G., Parsons, L. H. Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats Journal of Neurochemistry  2009 111:37-48  DOI:10.1111/j.1471-4159.2009.06301.x  PMID:19650871  PMCID:PMC3946540
    • Abdallah, L., Bonasera, S. J., Hopf, F. W., O'Dell, L., Giorgetti, M., Jongsma, M., Carra, S., Pierucci, M., Di Giovanni, G., Esposito, E., Parsons, L. H., Bonci, A., et al. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function Journal of Neuroscience  2009 29:8156-8165  DOI:10.1523/jneurosci.3905-08.2009  PMID:19553455  PMCID:PMC3077993
    • Orio, L., Edwards, S., George, O., Parsons, L. H., Koob, G. F. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions Journal of Neuroscience  2009 29:4846-4857  DOI:10.1523/jneurosci.0563-09.2009  PMID:19369553  PMCID:PMC2688678
    • Poceta, J. S., Parsons, L., Engelland, S., Kripke, D. F. Circadian rhythm of CSF monoamines and hypocretin-1 in restless legs syndrome and Parkinson's disease Sleep Medicine  2009 10:129-133  DOI:10.1016/j.sleep.2007.11.002  PMID:18207455
    • Long, J. Z., Li, W. W., Booker, L., Burston, J. J., Kinsey, S. G., Schlosburg, J. E., Pavon, F. J., Serrano, A. M., Selley, D. E., Parsons, L. H., Lichtman, A. H., Cravatt, B. F. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects Nature Chemical Biology  2009 5:37-44  DOI:10.1038/nchembio.129  PMID:19029917  PMCID:PMC2605181
    • Qu, Y., Swerdlow, N. R., Weber, M., Stouffer, D., Parsons, L. H. Quinelorane, a dopamine D3/D2 receptor agonist, reduces prepulse inhibition of startle and ventral pallidal GABA efflux: time course studies Pharmacology, Biochemistry and Behavior  2008 90:686-690  DOI:10.1016/j.pbb.2008.05.012  PMID:18579193  PMCID:PMC3250091
    • Alvarez-Jaimes, L., Polis, I., Parsons, L. H. Attenuation of cue-induced heroin-seeking behavior by cannabinoid CB(1) antagonist infusions into the nucleus accumbens core and prefrontal cortex, but not basolateral amygdala Neuropsychopharmacology  2008 33:2483-2493  DOI:10.1038/sj.npp.1301630  PMID:18059440
    • George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., Koob, G. F. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats Proceedings of the National Academy of Sciences of the United States of America  2007 104:17198-17203  DOI:10.1073/pnas.0707585104  PMID:17921249  PMCID:PMC2040467
    • Ferrer, B., Bermudez-Silva, F. J., Bilbao, A., Alvarez-Jaimes, L., Sanchez-Vera, I., Giuffrida, A., Serrano, A., Baixeras, E., Khaturia, S., Navarro, M., Parsons, L. H., Piomelli, D., et al. Regulation of brain anandamide by acute administration of ethanol Biochemical Journal  2007 404:97-104  DOI:10.1042/bj20061898  PMID:17302558  PMCID:PMC1868843
    • Caille, S., Alvarez-Jaimes, L., Polis, I., Stouffer, D. G., Parsons, L. H. Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration Journal of Neuroscience  2007 27:3695-3702  DOI:10.1523/jneurosci.4403-06.2007  PMID:17409233
    • Frantz, K. J., O'Dell, L. E., Parsons, L. H. Behavioral and neurochemical responses to cocaine in periadolescent and adult rats Neuropsychopharmacology  2007 32:625-637  DOI:10.1038/sj.npp.1301130  PMID:16794567
    • O'Dell, L. E., Manzardo, A. M., Polis, I., Stouffer, D. G., Parsons, L. H. Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration Journal of Neurochemistry  2006 99:1363-1376  DOI:10.1111/j.1471-4159.2006.04163.x  PMID:17074068
    • Guillem, K., Vouillac, C., Azar, M. R., Parsons, L. H., Koob, G. F., Cador, M., Stinus, L. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats European Journal of Neuroscience  2006 24:3532-3540  DOI:10.1111/j.1460-9568.2006.05217.x  PMID:17229101
    • O'Dell, L. E., Bruijnzeel, A. W., Smith, R. T., Parsons, L. H., Merves, M. L., Goldberger, B. A., Richardson, H. N., Koob, G. F., Markou, A. Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction Psychopharmacology  2006 186:612-619  DOI:10.1007/s00213-006-0383-6  PMID:16598454
    • Selvage, D. J., Parsons, L., Rivier, C. Role played by brainstem neurons in regulating testosterone secretion via a direct neural pathway between the hypothalamus and the testes Endocrinology  2006 147:3070-3075  DOI:10.1210/en.2005-1358  PMID:16556770
    • Breese, G. R., Criswell, H. E., Carta, M., Dodson, P. D., Hanchar, H. J., Khisti, R. T., Mameli, M., Ming, Z., Morrow, A. L., Olsen, R. W., Otis, T. S., Parsons, L. H., et al. Basis of the gabamimetic profile of ethanol Alcoholism-Clinical and Experimental Research  2006 30:731-744  DOI:10.1111/j.0145-6008.2006.00086.x  PMID:16573592  PMCID:PMC2958095
    • Caille, S., Parsons, L. H. Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway Neuropsychopharmacology  2006 31:804-813  DOI:10.1038/sj.npp.1300848  PMID:16123766
    • Guillem, K., Vouillac, C., Azar, M. R., Parsons, L. H., Koob, G. F., Cador, M., Stinus, L. Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats Journal of Neuroscience  2005 25:8593-8600  DOI:10.1523/jneurosci.2139-05.2005  PMID:16177026
    • Madden, L. J., Flynn, C. T., Zandonatti, M. A., May, M., Parsons, L. H., Katner, S. N., Henriksen, S. J., Fox, H. S. Modeling human methamphetamine exposure in nonhuman primates: chronic dosing in the rhesus macaque leads to behavioral and physiological abnormalities Neuropsychopharmacology  2005 30:350-359  DOI:10.1038/sj.npp.1300575  PMID:15483561
    • Roberto, M., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Increased GABA release in the central amygdala of ethanol-dependent rats Journal of Neuroscience  2004 24:10159-10166  DOI:10.1523/jneurosci.3004-04.2004  PMID:15537886
    • O'Dell, L. E., Parsons, L. H. Serotonin(1B) receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels Journal of Pharmacology and Experimental Therapeutics  2004 311:711-719  DOI:10.1124/jpet.104.069278  PMID:15226384
    • Caille, S., Parsons, L. H. Intravenous heroin self-administration decreases GABA efflux in the ventral pallidum: an in vivo microdialysis study in rats European Journal of Neuroscience  2004 20:593-596  DOI:10.1111/j.1460-9568.2004.03497.x  PMID:15233770
    • Selvage, D. J., Lee, S. Y., Parsons, L. H., Seo, D. O., Rivier, C. L. A hypothalamic-testicular neural pathway is influenced by brain catecholamines, but not testicular blood flow Endocrinology  2004 145:1750-1759  DOI:10.1210/en.2003-1441  PMID:14684600
    • Roberto, M., Schweitzer, P., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis Journal of Neuroscience  2004 24:1594-1603  DOI:10.1523/jneurosci.5077-03.2004  PMID:14973247
    • Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., O'Dell, L. E., Parsons, L. H., Sanna, P. P. Neurobiological mechanisms in the transition from drug use to drug dependence Neuroscience and Biobehavioral Reviews  2004 27:739-749  DOI:10.1016/j.neubiorev.2003.11.007  PMID:15019424
    • Caille, S., Parsons, L. H. SR141716A reduces the reinforcing properties of heroin but not heroin-induced increases in nucleus accumbens dopamine in rats European Journal of Neuroscience  2003 18:3145-3149  DOI:10.1046/j.1460-9568.2003.02961.x  PMID:14656311
    • Taffe, M. A., Huitron-Resendiz, S., Schroeder, R., Parsons, L. H., Henriksen, S. J., Gold, L. H. MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys Pharmacology, Biochemistry and Behavior  2003 76:141-152  DOI:10.1016/s0091-3057(03)00217-x  PMID:13679227
    • Ahmed, S. H., Lin, D., Koob, G. F., Parsons, L. H. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels Journal of Neurochemistry  2003 86:102-113  DOI:10.1046/j.1471-4159.2003.01833.x  PMID:12807430
    • Taffe, M. A., Davis, S. A., Yuan, J., Schroeder, R., Hatzidimitriou, G., Parsons, L. H., Ricaurte, G. A., Gold, L. H. Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge Neuropsychopharmacology  2002 27:993-1005  DOI:10.1016/s0893-133x(02)00380-9  PMID:12464456
    • Rocha, B. A., Goulding, E. H., O'Dell, L. E., Mead, A. N., Coufal, N. G., Parsons, L. H., Tecott, L. H. Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice Journal of Neuroscience  2002 22:10039-10045  PMID:12427861
    • Lin, D., Parsons, L. H. Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze Pharmacology, Biochemistry and Behavior  2002 71:581-587  DOI:10.1016/s0091-3057(01)00712-2  PMID:11888549
    • Hungund, B. L., Basavarajappa, B. S., Vadasz, C., Kunos, G., de Fonseca, F. R., Colombo, G., Serra, S., Parsons, L., Koob, G. F. Ethanol, endocannabinoids, and the cannabinoidergic signaling system Alcoholism-Clinical and Experimental Research  2002 26:565-574  DOI:10.1111/j.1530-0277.2002.tb02575.x  PMID:11981134
    • Frantz, K. J., Hansson, K. J., Stouffer, D. G., Parsons, L. H. 5-HT(6) receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine Neuropharmacology  2002 42:170-180  DOI:10.1016/s0028-3908(01)00165-4  PMID:11804613
    • Parsons, L. H., Kerr, T. M., Tecott, L. H. 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission Journal of Neurochemistry  2001 77:607-617  DOI:10.1046/j.1471-4159.2001.00254.x  PMID:11299323
    • Taffe, M. A., Weed, M. R., Davis, S., Huitron-Resendiz, S., Schroeder, R., Parsons, L. H., Henriksen, S. J., Gold, L. H. Functional consequences of repeated (+/-)3,4-methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys Neuropsychopharmacology  2001 24:230-239  DOI:10.1016/s0893-133x(00)00185-8  PMID:11166514
    • Weiss, F., Ciccocioppo, R., Parsons, L. H., Katner, S., Liu, X., Zorrilla, E. P., Valdez, G. R., Ben-Shahar, O., Angeletti, S., Richter, R. R. Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors Annals of the New York Academy of Sciences  2001 937:1-26  DOI:10.1111/j.1749-6632.2001.tb03556.x  PMID:11458532
    • Solbrig, M. V., Koob, G. F., Parsons, L. H., Kadota, T., Horscroft, N., Briese, T., Lipkin, W. I. Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability Journal of Neuroscience  2000 20:RC104  PMID:11050146
    • Weiss, F., Maldonado-Vlaar, C. S., Parsons, L. H., Kerr, T. M., Smith, D. L., Ben-Shahar, O. Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens Proceedings of the National Academy of Sciences of the United States of America  2000 97:4321-4326  DOI:10.1073/pnas.97.8.4321  PMID:10760299  PMCID:PMC18240
    • Parsons, L. H., Koob, G. F., Weiss, F. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine Synapse  1999 32:132-135  DOI:10.1002/(sici)1098-2396(199905)32:2<132::aid-syn6>3.0.co;2-v  PMID:10231132
    • Giuffrida, A., Parsons, L. H., Kerr, T. M., de Fonseca, F. R., Navarro, M., Piomelli, D. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum Nature Neuroscience  1999 2:358-363  DOI:10.1038/7268  PMID:10204543
    • Harrison, A. A., Parsons, L. H., Koob, G. F., Markou, A. RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist Psychopharmacology  1999 141:242-250  DOI:10.1007/s002130050831  PMID:10027505
    • Heisler, L. K., Chu, H. M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., Tecott, L. H. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice Proceedings of the National Academy of Sciences of the United States of America  1998 95:15049-15054  DOI:10.1073/pnas.95.25.15049  PMID:9844013  PMCID:PMC24573
    • Parsons, L. H., Weiss, F., Koob, G. F. Serotonin(1B) receptor stimulation enhances cocaine reinforcement Journal of Neuroscience  1998 18:10078-10089  PMID:9822762
    • Koob, G. F., Rocio, M., Carrera, A., Gold, L. H., Heyser, C. J., Maldonado-Irizarry, C., Markou, A., Parsons, L. H., Roberts, A. J., Schulteis, G., Stinus, L., Walker, J. R., et al. Substance dependence as a compulsive behavior Journal of Psychopharmacology  1998 12:39-48  DOI:10.1177/026988119801200106  PMID:9584967
    • Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyytia, P., Merlo-Pich, E., Weiss, F. Neurocircuitry targets in ethanol reward and dependence Alcoholism-Clinical and Experimental Research  1998 22:3-9  DOI:10.1097/00000374-199802000-00001  PMID:9514280
    • Parsons, L. H., Kerr, T. M., Weiss, F. Simple microbore high-performance liquid chromatographic method for the determination of dopamine and cocaine from a single in vivo brain microdialysis sample Journal of Chromatography B  1998 709:35-45  DOI:10.1016/s0378-4347(98)00024-3  PMID:9653924
    • Caine, S. B., Koob, G. F., Parsons, L. H., Everitt, B. J., Schwartz, J. C., Sokoloff, P. D3 receptor test in vitro predicts decreased cocaine self-administration in rats Neuroreport  1997 8:2373-2377  DOI:10.1097/00001756-199707070-00054  PMID:9243643
    • Koob, G. F., Caine, S. B., Parsons, L., Markou, A., Weiss, F. Opponent process model and psychostimulant addiction Pharmacology, Biochemistry and Behavior  1997 57:513-521  DOI:10.1016/s0091-3057(96)00438-8  PMID:9218276
    • Raber, J., Mehta, P. P., Kreifeldt, M., Parsons, L. H., Weiss, F., Bloom, F. E., Wilson, M. C. Coloboma hyperactive mutant mice exhibit regional and transmitter-specific deficits in neurotransmission Journal of Neurochemistry  1997 68:176-186  DOI:10.1046/j.1471-4159.1997.68010176.x  PMID:8978724
    • Parsons, L. H., Koob, G. F., Weiss, F. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration Behavioural Brain Research  1996 73:225-228  DOI:10.1016/0166-4328(96)00101-5  PMID:8788507
    • Parsons, L. H., Weiss, F., Koob, G. F. Serotonin(1B) receptor stimulation enhances dopamine mediated reinforcement Psychopharmacology  1996 128:150-160  DOI:10.1007/s002130050120  PMID:8956376
    • Weiss, F., Parsons, L. H., Schulteis, G., Hyytia, P., Lorang, M. T., Bloom, F. E., Koob, G. F. Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats Journal of Neuroscience  1996 16:3474-3485  PMID:8627380
    • Parsons, L. H., Caine, S. B., Sokoloff, P., Schwartz, J. C., Koob, G. F., Weiss, F. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement Journal of Neurochemistry  1996 67:1078-1089  DOI:10.1046/j.1471-4159.1996.67031078.x  PMID:8752115
    • Carrera, M. R. A., Ashley, J. A., Parsons, L. H., Wirsching, P., Koob, G. F., Janda, K. D. Suppression of psychoactive effects of cocaine by active immunization Nature  1995 378:727-730  DOI:10.1038/378727a0  PMID:7501020
    • Parsons, L. H., Koob, G. F., Weiss, F. Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine Journal of Pharmacology and Experimental Therapeutics  1995 274:1182-1191  PMID:7562486
    • Cosford, R. J. O., Parsons, L. H., Justice, J. B. Effect of tetrodotoxin and potassium infusion on microdialysis extraction fraction and extracellular dopamine in the nucleus accumbens Neuroscience Letters  1994 178:175-178  DOI:10.1016/0304-3940(94)90753-6  PMID:7824191
    • Parsons, L. H., Justice, J. B. Quantitative approaches to in vivo brain microdialysis Critical Reviews in Neurobiology  1994 8:189-220  PMID:7923396
    • Parsons, L. H., Justice, J. B. Serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area, and dorsal raphe nucleus following repeated cocaine administration Journal of Neurochemistry  1993 61:1611-1619  DOI:10.1111/j.1471-4159.1993.tb09794.x  PMID:7693863
    • Parsons, L. H., Justice, J. B. Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis Brain Research  1993 606:195-199  DOI:10.1016/0006-8993(93)90984-u  PMID:8490716
    • Parsons, L. H., Schad, C. A., Justice, J. B. Co-administration of the D2 antagonist pimozide inhibits up-regulation of dopamine release and uptake induced by repeated cocaine Journal of Neurochemistry  1993 60:376-379  DOI:10.1111/j.1471-4159.1993.tb05864.x  PMID:8417161
    • Parsons, L. H., Justice, J. B. Extracellular concentration and in vivo recovery of dopamine in the nucleus accumbens using microdialysis Journal of Neurochemistry  1992 58:212-218  DOI:10.1111/j.1471-4159.1992.tb09298.x  PMID:1727431
    • Parsons, L. H., Smith, A. D., Justice, J. B. The in vivo microdialysis recovery of dopamine is altered independently of basal level by 6-hydroxydopamine lesions to the nucleus accumbens Journal of Neuroscience Methods  1991 40:139-147  DOI:10.1016/0165-0270(91)90063-6  PMID:1800851
    • Parsons, L. H., Smith, A. D., Justice, J. B. Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine Synapse  1991 9:60-65  DOI:10.1002/syn.890090109  PMID:1796352
    • Pettit, H. O., Pan, H. T., Parsons, L. H., Justice, J. B. Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration Journal of Neurochemistry  1990 55:798-804  DOI:10.1111/j.1471-4159.1990.tb04562.x  PMID:2384752

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  • Serotonin Receptors and Drug Abuse  Newsletter
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Research

research overview

  • Our research is focused on the neurochemical mechanisms contributing to drug reward, dependence and relapse with a goal of identifying novel pharmacotherapeutic targets for addiction. Current projects seek to characterize alterations in motivation, affective state and cognitive function resulting from long-term drug exposure with a particular focus on dependence-related disruptions in the function and influence of the endogenous cannabinoid system.
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Teaching

advisees

  • graduate advising relationship

    • Irimia, Cristina, Ph.D.  candidate, 2009 - 2014
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Background

education and training

  • Ph.D. in Chemistry, Emory University 1992
  • B.A. in Chemistry, Whitman College 1988
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Contact

full name

  • Loren H. Parsons

geographic location

  • Scripps California 

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