Parsons, Loren (Larry)

Person

Positions

2010 - 2016 Associate Professor, Committee on the Neurobiology of Addictive Disorders (CNAD) , Scripps Research
1998 - 2016 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
2003 - 2009 Associate Professor, Committee on the Neurobiology of Addictive Disorders (CNAD) , Scripps Research
1998 - 2003 Assistant Professor, Neuropharmacology , Scripps Research
1995 - 1998 Senior Research Associate, Neuropharmacology , Scripps Research
1992 - 1995 Postdoctoral Fellow, Neuropharmacology , Scripps Research

Dr. Loren Parsons studies neurochemical mechanisms in drug dependence with the goal of characterizing neural pathologies that may be viable targets for a pharmacotherapy of addiction; particular focus is on the central serotonin and endocannabinoid systems.

Research Areas

Mental Illness (UMLS)

Publications
Research
Teaching
Background
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recent publications

academic article
- Agoglia, A. E., Zhu, M., Ying, R., Sidhu, H., Natividad, L. A., Wolfe, S. A., Buczynski, M. W., Contet, C., Parsons, L. H., Roberto, M., Herman, M. A. Corticotropin-releasing factor receptor-1 neurons in the lateral amygdala display selective sensitivity to acute and chronic ethanol exposure Eneuro 2020 7 DOI:10.1523/eneuro.0420-19.2020 PMID:32041742 PMCID:PMC7059189
- Pavon, F. J., Serrano, A., Stouffer, D. G., Polis, I., Roberto, M., Cravatt, B. F., Martin-Fardon, R., de Fonseca, F. R., Parsons, L. H. Ethanol-induced alterations in endocannabinoids and relevant neurotransmitters in the nucleus accumbens of fatty acid amide hydrolase knockout mice Addiction Biology 2019 24:1204-1215 DOI:10.1111/adb.12695 PMID:30421483 PMCID:PMC6551299
- Kirson, D., Oleata, C. S., Parsons, L. H., Ciccocioppo, R., Roberto, M. CB1 and ethanol effects on glutamatergic transmission in the central amygdala of male and female msP and Wistar rats Addiction Biology 2018 23:676-688 DOI:10.1111/adb.12525 PMID:28656627 PMCID:PMC5745318
- Moreno, M., Decara, J., Pavon, F. J., Stouffer, D. G., Edwards, S., Serrano, A., Suarez, J., Parsons, L. H., de Fonseca, F. R. Cannabinoid dependence induces sustained changes in GABA release in the globus pallidus without affecting dopamine release in the dorsal striatum: A dual microdialysis probe study Addiction Biology 2018 23:1251-1261 DOI:10.1111/adb.12694 PMID:30421559
- Serrano, A., Pavon, F. J., Buczynski, M. W., Schlosburg, J., Natividad, L. A., Polis, I. Y., Stouffer, D. G., Zorrilla, E. P., Roberto, M., Cravatt, B. F., Martin-Fardon, R., de Fonseca, F. R., et al. Deficient endocannabinoid signaling in the central amygdala contributes to alcohol dependence-related anxiety-like behavior and excessive alcohol intake Neuropsychopharmacology 2018 43:1840-1850 DOI:10.1038/s41386-018-0055-3 PMID:29748627 PMCID:PMC6046053
- Pavon, F. J., Serrano, A., Sidhpura, N., Polis, I., Stouffer, D., de Fonseca, F. R., Cravatt, B. F., Martin-Fardon, R., Parsons, L. H. Fatty acid amide hydrolase (FAAH) inactivation confers enhanced sensitivity to nicotine-induced dopamine release in the mouse nucleus accumbens Addiction Biology 2018 23:723-734 DOI:10.1111/adb.12531 PMID:28660730 PMCID:PMC5747548
- Natividad, L. A., Steinman, M. Q., Laredo, S. A., Irimia, C., Polis, I. Y., Lintz, R., Buczynski, M. W., Martin-Fardon, R., Roberto, M., Parsons, L. H. Phosphorylation of calcium/calmodulin-dependent protein kinase II in the rat dorsal medial prefrontal cortex is associated with alcohol-induced cognitive inflexibility Addiction Biology 2018 23:1117-1129 DOI:10.1111/adb.12568 PMID:28940879 PMCID:PMC5862723
- Berger, A. L., Henricks, A. M., Lugo, J. M., Wright, H. R., Warrick, C. R., Sticht, M. A., Morena, M., Bonilla, I., Laredo, S. A., Craft, R. M., Parsons, L. H., Grandes, P. R., et al. The lateral habenula directs coping styles under conditions of stress via recruitment of the endocannabinoid system Biological Psychiatry 2018 84:611-623 DOI:10.1016/j.biopsych.2018.04.018 PMID:29887035 PMCID:PMC6162143
- Gonzalez-Cuevas, G., Martin-Fardon, R., Kerr, T. M., Stouffer, D. G., Parsons, L. H., Hammell, D. C., Banks, S. L., Stinchcomb, A. L., Weiss, F. Unique treatment potential of cannabidiol for the prevention of relapse to drug use: preclinical proof of principle Neuropsychopharmacology 2018 43:2036-2045 DOI:10.1038/s41386-018-0050-8 PMID:29686308 PMCID:PMC6098033
- Formisano, S., Hornig, M., Yaddanapudi, K., Vasishtha, M., Parsons, L. H., Briese, T., Lipkin, W. I., Williams, B. L. Central nervous system infection with Borna disease virus causes kynurenine pathway dysregulation and neurotoxic quinolinic acid production Journal of Virology 2017 91:e00673-17 DOI:10.1128/jvi.00673-17 PMID:28446679 PMCID:PMC5487560
- Natividad, L. A., Buczynski, M. W., Herman, M. A., Kirson, D., Oleata, C. S., Irimia, C., Polis, I., Ciccocioppo, R., Roberto, M., Parsons, L. H. Constitutive increases in amygdalar corticotropin-releasing factor and fatty acid amide hydrolase drive an anxious phenotype Biological Psychiatry 2017 82:500-510 DOI:10.1016/j.biopsych.2017.01.005 PMID:28209423 PMCID:PMC5509512
- Irimia, C., Buczynski, M. W., Natividad, L. A., Laredo, S. A., Avalos, N., Parsons, L. H. Dysregulated glycine signaling contributes to increased impulsivity during protracted alcohol abstinence Journal of Neuroscience 2017 37:1853-1861 DOI:10.1523/jneurosci.2466-16.2017 PMID:28202787 PMCID:PMC5320613
- Varodayan, F. P., Soni, N., Bajo, M., Luu, G., Madamba, S. G., Schweitzer, P., Parsons, L. H., Roberto, M. Chronic ethanol exposure decreases CB1 receptor function at GABAergic synapses in the rat central amygdala Addiction Biology 2016 21:788-801 DOI:10.1111/adb.12256 PMID:25940135 PMCID:PMC4635109
- Buczynski, M. W., Herman, M. A., Hsu, K. L., Natividad, L. A., Irimia, C., Polis, I. Y., Pugh, H., Chang, J. W., Niphakis, M. J., Cravatt, B. F., Roberto, M., Parsons, L. H. Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure Proceedings of the National Academy of Sciences of the United States of America 2016 113:1086-1091 DOI:10.1073/pnas.1522672113 PMID:26755579 PMCID:PMC4743781
- Nguyen, J. D., Aarde, S. M., Vandewater, S. A., Grant, Y., Stouffer, D. G., Parsons, L. H., Cole, M., Taffe, M. A. Inhaled delivery of Δ(9)-tetrahydrocannabinol (THC) to rats by e-cigarette vapor technology Neuropharmacology 2016 109:112-120 DOI:10.1016/j.neuropharm.2016.05.021 PMID:27256501 PMCID:PMC4970926
- Curran, H. V., Freeman, T. P., Mokrysz, C., Lewis, D. A., Morgan, C. J. A., Parsons, L. H. Keep off the grass? Cannabis, cognition and addiction Nature Reviews Neuroscience 2016 17:293-306 DOI:10.1038/nrn.2016.28 PMID:27052382
- Souza-Smith, F. M., Lang, C. H., Nagy, L. E., Bailey, S. M., Parsons, L. H., Murray, G. J. Physiological processes underlying organ injury in alcohol abuse American Journal of Physiology-Endocrinology and Metabolism 2016 311:E605-E619 DOI:10.1152/ajpendo.00270.2016 PMID:27436613
- Bilbao, A., Serrano, A., Cippitelli, A., Pavon, F. J., Giuffrida, A., Suarez, J., Garcia-Marchena, N., Baixeras, E., Gómez de Heras, R., Orio, L., Alen, F., Ciccocioppo, R., et al. Role of the satiety factor oleoylethanolamide in alcoholism Addiction Biology 2016 21:859-872 DOI:10.1111/adb.12276 PMID:26037332 PMCID:PMC4668242
- Liu, J., Parsons, L., Pope, C. Comparative effects of parathion and chlorpyrifos on endocannabinoid and endocannabinoid-like lipid metabolites in rat striatum Neurotoxicology 2015 50:20-27 DOI:10.1016/j.neuro.2015.07.006 PMID:26215119 PMCID:PMC4767275
- Parsons, L. H., Hurd, Y. L. Endocannabinoid signalling in reward and addiction Nature Reviews Neuroscience 2015 16:579-594 DOI:10.1038/nrn4004 PMID:26373473 PMCID:PMC4652927
- Herman, M. A., Sidhu, H., Stouffer, D. G., Kreifeldt, M., Le, D., Cates-Gatto, C., Munoz, M. B., Roberts, A. J., Parsons, L. H., Roberto, M., Wickman, K., Slesinger, P. A., et al. GIRK3 gates activation of the mesolimbic dopaminergic pathway by ethanol Proceedings of the National Academy of Sciences of the United States of America 2015 112:7091-7096 DOI:10.1073/pnas.1416146112 PMID:25964320 PMCID:PMC4460485
- Irimia, C., Wiskerke, J., Natividad, L. A., Polis, I. Y., de Vries, T. J., Pattij, T., Parsons, L. H. Increased impulsivity in rats as a result of repeated cycles of alcohol intoxication and abstinence Addiction Biology 2015 20:263-274 DOI:10.1111/adb.12119 PMID:24341858 PMCID:PMC4061283
- Irimia, C., Polis, I. Y., Stouffer, D., Parsons, L. H. Persistent effects of chronic Δ9-THC exposure on motor impulsivity in rats Psychopharmacology 2015 232:3033-3043 DOI:10.1007/s00213-015-3942-x PMID:25925779
- De Luca, M. A., Bimpisidis, Z., Melis, M., Marti, M., Caboni, P., Valentini, V., Margiani, G., Pintori, N., Polis, I., Marsicano, G., Parsons, L. H., Di Chiara, G. Stimulation of in vivo dopamine transmission and intravenous self-administration in rats and mice by JWH-018, a Spice cannabinoid Neuropharmacology 2015 99:705-714 DOI:10.1016/j.neuropharm.2015.08.041 PMID:26327678
- Irimia, C., Tuong, R. N., Quach, T., Parsons, L. H. Impaired response inhibition in the rat 5 choice continuous performance task during protracted abstinence from chronic alcohol consumption PLoS One 2014 9:e109948 DOI:10.1371/journal.pone.0109948 PMID:25333392 PMCID:PMC4198178
- Gonzalez-Aparicio, R., Blanco, E., Serrano, A., Pavon, F. J., Parsons, L. H., Maldonado, R., Robledo, P., Fernandez-Espejo, E., de Fonseca, F. R. The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism International Journal of Neuropsychopharmacology 2014 17:455-468 DOI:10.1017/s1461145713001259 PMID:24169105
- Talantova, M., Sanz-Blasco, S., Zhang, X. F., Xia, P., Akhtar, M. W., Okamoto, S., Dziewczapolski, G., Nakamura, T., Cao, G., Pratt, A. E., Kang, Y. J., Tu, S., et al. Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss Proceedings of the National Academy of Sciences of the United States of America 2013 110:E2518-E2527 DOI:10.1073/pnas.1306832110 PMID:23776240 PMCID:PMC3704025
- Liu, J., Parsons, L., Pope, C. Comparative effects of parathion and chlorpyrifos on extracellular endocannabinoid levels in rat hippocampus: Influence on cholinergic toxicity Toxicology and Applied Pharmacology 2013 272:608-615 DOI:10.1016/j.taap.2013.07.025 PMID:23933531 PMCID:PMC3831619
- Niphakis, M. J., Cognetta III, A. B., Chang, J. W., Buczynski, M. W., Parsons, L. H., Byrne, F., Burston, J. J., Chapman, V., Cravatt, B. F. Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors ACS Chemical Neuroscience 2013 4:1322-1332 DOI:10.1021/cn400116z PMID:23731016 PMCID:PMC3778430
- Muldoon, P. P., Lichtman, A. H., Parsons, L. H., Damaj, M. I. The role of fatty acid amide hydrolase inhibition in nicotine reward and dependence Life Sciences 2013 92:458-462 DOI:10.1016/j.lfs.2012.05.015 PMID:22705310 PMCID:PMC3477273
- Buczynski, M. W., Polis, I. Y., Parsons, L. H. The volitional nature of nicotine exposure alters anandamide and oleoylethanolamide levels in the ventral tegmental area Neuropsychopharmacology 2013 38:574-584 DOI:10.1038/npp.2012.210 PMID:23169348 PMCID:PMC3572454
- Wright, M. J., Vandewater, S. A., Parsons, L. H., Taffe, M. A. delta(9)Tetrahydrocannabinol impairs reversal learning but not extra-dimensional shifts in rhesus macaques Neuroscience 2013 235:51-58 DOI:10.1016/j.neuroscience.2013.01.018 PMID:23333671 PMCID:PMC3595391
- Natividad, L. A., Buczynski, M. W., Parsons, L. H., Torres, O. V., O'Dell, L. E. Adolescent rats are resistant to adaptations in excitatory and inhibitory mechanisms that modulate mesolimbic dopamine during nicotine withdrawal Journal of Neurochemistry 2012 123:578-588 DOI:10.1111/j.1471-4159.2012.07926.x PMID:22905672 PMCID:PMC3472122
- Serrano, A., Rivera, P., Pavon, F. J., Decara, J., Suarez, J., de Fonseca, F. R., Parsons, L. H. Differential effects of single versus repeated alcohol withdrawal on the expression of endocannabinoid system-related genes in the rat amygdala Alcoholism-Clinical and Experimental Research 2012 36:984-994 DOI:10.1111/j.1530-0277.2011.01686.x PMID:22141465 PMCID:PMC3297719
- Wright, M. J., Angrish, D., Aarde, S. M., Barlow, D. J., Buczynski, M. W., Creehan, K. M., Vandewater, S. A., Parsons, L. H., Houseknecht, K. L., Dickerson, T. J., Taffe, M. A. Effect of ambient temperature on the thermoregulatory and locomotor stimulant effects of 4-methylmethcathinone in Wistar and Sprague-Dawley rats PLoS One 2012 7:e44652 DOI:10.1371/journal.pone.0044652 PMID:22952999 PMCID:PMC3432134
- Chang, J. W., Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Wang, C., Matthews, M. L., Niessen, S., Buczynski, M. W., Parsons, L. H., Cravatt, B. F. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates Chemistry & Biology 2012 19:579-588 DOI:10.1016/j.chembiol.2012.03.009 PMID:22542104 PMCID:PMC3361572
- Ramchandani, V. A., Umhau, J., Pavon, F. J., Ruiz-Velasco, V., Margas, W., Sun, H., Damadzic, R., Eskay, R., Schoor, M., Thorsell, A., Schwandt, M. L., Sommer, W. H., et al. A genetic determinant of the striatal dopamine response to alcohol in men Molecular Psychiatry 2011 16:809-817 DOI:10.1038/mp.2010.56 PMID:20479755 PMCID:PMC2925052
- Serrano, A., Parsons, L. H. Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors Pharmacology & Therapeutics 2011 132:215-241 DOI:10.1016/j.pharmthera.2011.06.005 PMID:21798285 PMCID:PMC3209522
- Sidhpura, N., Parsons, L. H. Endocannabinoid-mediated synaptic plasticity and addiction-related behavior Neuropharmacology 2011 61:1070-1087 DOI:10.1016/j.neuropharm.2011.05.034 PMID:21669214 PMCID:PMC3176941
- Roberto, M., Cruz, M. T., Gilpin, N. W., Sabin, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., Koob, G. F., Siggins, G. R., et al. Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence Biological Psychiatry 2010 67:831-839 DOI:10.1016/j.biopsych.2009.11.007 PMID:20060104 PMCID:PMC2883449
- Plaza-Zabala, A., Berrendero, F., Suarez, J., Bermudez-Silva, F. J., Fernandez-Espejo, E., Serrano, A., Pavon, F. J., Parsons, L. H., De Fonseca, F. R., Maldonado, R., Robledo, P. Effects of the endogenous PPAR-alpha agonist, oleoylethanolamide on MDMA-induced cognitive deficits in mice Synapse 2010 64:379-389 DOI:10.1002/syn.20733 PMID:20029832
- Pope, C., Mechoulam, R., Parsons, L. Endocannabinoid signaling in neurotoxicity and neuroprotection Neurotoxicology 2010 31:562-571 DOI:10.1016/j.neuro.2009.12.002 PMID:19969019 PMCID:PMC2891218
- Huitron-Resendiz, S., Henriksen, S. J., Barr, M. C., Testa, M. P., Crawford, E., Parsons, L. H., Sanchez-Alavez, M., Phillips, T. R. Methamphetamine and lentivirus interactions: reciprocal enhancement of central nervous system disease Journal of Neurovirology 2010 16:268-278 DOI:10.3109/13550284.2010.497807 PMID:20608774
- Buczynski, M. W., Parsons, L. H. Quantification of brain endocannabinoid levels: methods, interpretations and pitfalls British Journal of Pharmacology 2010 160:423-442 DOI:10.1111/j.1476-5381.2010.00787.x PMID:20590555 PMCID:PMC2931546
- Roberto, M., Cruz, M., Bajo, M., Siggins, G. R., Parsons, L. H., Schweitzer, P. The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala Neuropsychopharmacology 2010 35:1962-1972 DOI:10.1038/npp.2010.70 PMID:20463657 PMCID:PMC2904853
- Orio, L., Edwards, S., George, O., Parsons, L. H., Koob, G. F. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions Journal of Neuroscience 2009 29:4846-4857 DOI:10.1523/jneurosci.0563-09.2009 PMID:19369553 PMCID:PMC2688678
- Neumaier, J. F., McDevitt, R. A., Polis, I. Y., Parsons, L. H. Acquisition of and withdrawal from cocaine self-administration regulates 5-HT(1B) mRNA expression in rat striatum Journal of Neurochemistry 2009 111:217-227 DOI:10.1111/j.1471-4159.2009.06313.x PMID:19659573
- Villanueva, A., Yilmaz, S. M., Millington, W. R., Cutrera, R. A., Stouffer, D. G., Parsons, L. H., Cheer, J. F., Feleder, C. Central cannabinoid 1 receptor antagonist administration prevents endotoxic hypotension affecting norepinephrine release in the preoptic anterior hypothalamic area Shock 2009 32:614-620 DOI:10.1097/SHK.0b013e3181a4fd8f PMID:19295473
- Alvarez-Jaimes, L., Stouffer, D. G., Parsons, L. H. Chronic ethanol treatment potentiates ethanol-induced increases in interstitial nucleus accumbens endocannabinoid levels in rats Journal of Neurochemistry 2009 111:37-48 DOI:10.1111/j.1471-4159.2009.06301.x PMID:19650871 PMCID:PMC3946540
- Poceta, J. S., Parsons, L., Engelland, S., Kripke, D. F. Circadian rhythm of CSF monoamines and hypocretin-1 in restless legs syndrome and Parkinson's disease Sleep Medicine 2009 10:129-133 DOI:10.1016/j.sleep.2007.11.002 PMID:18207455
- Abdallah, L., Bonasera, S. J., Hopf, F. W., O'Dell, L., Giorgetti, M., Jongsma, M., Carra, S., Pierucci, M., Di Giovanni, G., Esposito, E., Parsons, L. H., Bonci, A., et al. Impact of serotonin 2C receptor null mutation on physiology and behavior associated with nigrostriatal dopamine pathway function Journal of Neuroscience 2009 29:8156-8165 DOI:10.1523/jneurosci.3905-08.2009 PMID:19553455 PMCID:PMC3077993
- Qu, Y., Saint Marie, R., Breier, M. R., Ko, D., Stouffer, D., Parsons, L. H., Swerdlow, N. R. Neural basis for a heritable phenotype: differences in the effects of apomorphine on startle gating and ventral pallidal GABA efflux in male Sprague-Dawley and Long-Evans rats Psychopharmacology 2009 207:271-280 DOI:10.1007/s00213-009-1654-9 PMID:19756524 PMCID:PMC2770636
- Long, J. Z., Li, W. W., Booker, L., Burston, J. J., Kinsey, S. G., Schlosburg, J. E., Pavon, F. J., Serrano, A. M., Selley, D. E., Parsons, L. H., Lichtman, A. H., Cravatt, B. F. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects Nature Chemical Biology 2009 5:37-44 DOI:10.1038/nchembio.129 PMID:19029917 PMCID:PMC2605181
- Alvarez-Jaimes, L., Polis, I., Parsons, L. H. Attenuation of cue-induced heroin-seeking behavior by cannabinoid CB(1) antagonist infusions into the nucleus accumbens core and prefrontal cortex, but not basolateral amygdala Neuropsychopharmacology 2008 33:2483-2493 DOI:10.1038/sj.npp.1301630 PMID:18059440
- Qu, Y., Swerdlow, N. R., Weber, M., Stouffer, D., Parsons, L. H. Quinelorane, a dopamine D3/D2 receptor agonist, reduces prepulse inhibition of startle and ventral pallidal GABA efflux: time course studies Pharmacology, Biochemistry and Behavior 2008 90:686-690 DOI:10.1016/j.pbb.2008.05.012 PMID:18579193 PMCID:PMC3250091
- Frantz, K. J., O'Dell, L. E., Parsons, L. H. Behavioral and neurochemical responses to cocaine in periadolescent and adult rats Neuropsychopharmacology 2007 32:625-637 DOI:10.1038/sj.npp.1301130 PMID:16794567
- George, O., Ghozland, S., Azar, M. R., Cottone, P., Zorrilla, E. P., Parsons, L. H., O'Dell, L. E., Richardson, H. N., Koob, G. F. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats Proceedings of the National Academy of Sciences of the United States of America 2007 104:17198-17203 DOI:10.1073/pnas.0707585104 PMID:17921249 PMCID:PMC2040467
- Ferrer, B., Bermudez-Silva, F. J., Bilbao, A., Alvarez-Jaimes, L., Sanchez-Vera, I., Giuffrida, A., Serrano, A., Baixeras, E., Khaturia, S., Navarro, M., Parsons, L. H., Piomelli, D., et al. Regulation of brain anandamide by acute administration of ethanol Biochemical Journal 2007 404:97-104 DOI:10.1042/bj20061898 PMID:17302558 PMCID:PMC1868843
- Caille, S., Alvarez-Jaimes, L., Polis, I., Stouffer, D. G., Parsons, L. H. Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration Journal of Neuroscience 2007 27:3695-3702 DOI:10.1523/jneurosci.4403-06.2007 PMID:17409233
- Breese, G. R., Criswell, H. E., Carta, M., Dodson, P. D., Hanchar, H. J., Khisti, R. T., Mameli, M., Ming, Z., Morrow, A. L., Olsen, R. W., Otis, T. S., Parsons, L. H., et al. Basis of the gabamimetic profile of ethanol Alcoholism-Clinical and Experimental Research 2006 30:731-744 DOI:10.1111/j.0145-6008.2006.00086.x PMID:16573592 PMCID:PMC2958095
- O'Dell, L. E., Manzardo, A. M., Polis, I., Stouffer, D. G., Parsons, L. H. Biphasic alterations in serotonin-1B (5-HT1B) receptor function during abstinence from extended cocaine self-administration Journal of Neurochemistry 2006 99:1363-1376 DOI:10.1111/j.1471-4159.2006.04163.x PMID:17074068
- Caille, S., Parsons, L. H. Cannabinoid modulation of opiate reinforcement through the ventral striatopallidal pathway Neuropsychopharmacology 2006 31:804-813 DOI:10.1038/sj.npp.1300848 PMID:16123766
- O'Dell, L. E., Bruijnzeel, A. W., Smith, R. T., Parsons, L. H., Merves, M. L., Goldberger, B. A., Richardson, H. N., Koob, G. F., Markou, A. Diminished nicotine withdrawal in adolescent rats: implications for vulnerability to addiction Psychopharmacology 2006 186:612-619 DOI:10.1007/s00213-006-0383-6 PMID:16598454
- Guillem, K., Vouillac, C., Azar, M. R., Parsons, L. H., Koob, G. F., Cador, M., Stinus, L. Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats European Journal of Neuroscience 2006 24:3532-3540 DOI:10.1111/j.1460-9568.2006.05217.x PMID:17229101
- Selvage, D. J., Parsons, L., Rivier, C. Role played by brainstem neurons in regulating testosterone secretion via a direct neural pathway between the hypothalamus and the testes Endocrinology 2006 147:3070-3075 DOI:10.1210/en.2005-1358 PMID:16556770
- Madden, L. J., Flynn, C. T., Zandonatti, M. A., May, M., Parsons, L. H., Katner, S. N., Henriksen, S. J., Fox, H. S. Modeling human methamphetamine exposure in nonhuman primates: chronic dosing in the rhesus macaque leads to behavioral and physiological abnormalities Neuropsychopharmacology 2005 30:350-359 DOI:10.1038/sj.npp.1300575 PMID:15483561
- Guillem, K., Vouillac, C., Azar, M. R., Parsons, L. H., Koob, G. F., Cador, M., Stinus, L. Monoamine oxidase inhibition dramatically increases the motivation to self-administer nicotine in rats Journal of Neuroscience 2005 25:8593-8600 DOI:10.1523/jneurosci.2139-05.2005 PMID:16177026
- Selvage, D. J., Lee, S. Y., Parsons, L. H., Seo, D. O., Rivier, C. L. A hypothalamic-testicular neural pathway is influenced by brain catecholamines, but not testicular blood flow Endocrinology 2004 145:1750-1759 DOI:10.1210/en.2003-1441 PMID:14684600
- Roberto, M., Schweitzer, P., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis Journal of Neuroscience 2004 24:1594-1603 DOI:10.1523/jneurosci.5077-03.2004 PMID:14973247
- Roberto, M., Madamba, S. G., Stouffer, D. G., Parsons, L. H., Siggins, G. R. Increased GABA release in the central amygdala of ethanol-dependent rats Journal of Neuroscience 2004 24:10159-10166 DOI:10.1523/jneurosci.3004-04.2004 PMID:15537886
- Caille, S., Parsons, L. H. Intravenous heroin self-administration decreases GABA efflux in the ventral pallidum: an in vivo microdialysis study in rats European Journal of Neuroscience 2004 20:593-596 DOI:10.1111/j.1460-9568.2004.03497.x PMID:15233770
- Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., O'Dell, L. E., Parsons, L. H., Sanna, P. P. Neurobiological mechanisms in the transition from drug use to drug dependence Neuroscience and Biobehavioral Reviews 2004 27:739-749 DOI:10.1016/j.neubiorev.2003.11.007 PMID:15019424
- O'Dell, L. E., Parsons, L. H. Serotonin(1B) receptors in the ventral tegmental area modulate cocaine-induced increases in nucleus accumbens dopamine levels Journal of Pharmacology and Experimental Therapeutics 2004 311:711-719 DOI:10.1124/jpet.104.069278 PMID:15226384
- Ahmed, S. H., Lin, D., Koob, G. F., Parsons, L. H. Escalation of cocaine self-administration does not depend on altered cocaine-induced nucleus accumbens dopamine levels Journal of Neurochemistry 2003 86:102-113 DOI:10.1046/j.1471-4159.2003.01833.x PMID:12807430
- Taffe, M. A., Huitron-Resendiz, S., Schroeder, R., Parsons, L. H., Henriksen, S. J., Gold, L. H. MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys Pharmacology, Biochemistry and Behavior 2003 76:141-152 DOI:10.1016/s0091-3057(03)00217-x PMID:13679227
- Caille, S., Parsons, L. H. SR141716A reduces the reinforcing properties of heroin but not heroin-induced increases in nucleus accumbens dopamine in rats European Journal of Neuroscience 2003 18:3145-3149 DOI:10.1046/j.1460-9568.2003.02961.x PMID:14656311
- Frantz, K. J., Hansson, K. J., Stouffer, D. G., Parsons, L. H. 5-HT(6) receptor antagonism potentiates the behavioral and neurochemical effects of amphetamine but not cocaine Neuropharmacology 2002 42:170-180 DOI:10.1016/s0028-3908(01)00165-4 PMID:11804613
- Lin, D., Parsons, L. H. Anxiogenic-like effect of serotonin(1B) receptor stimulation in the rat elevated plus-maze Pharmacology, Biochemistry and Behavior 2002 71:581-587 DOI:10.1016/s0091-3057(01)00712-2 PMID:11888549
- Taffe, M. A., Davis, S. A., Yuan, J., Schroeder, R., Hatzidimitriou, G., Parsons, L. H., Ricaurte, G. A., Gold, L. H. Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge Neuropsychopharmacology 2002 27:993-1005 DOI:10.1016/s0893-133x(02)00380-9 PMID:12464456
- Rocha, B. A., Goulding, E. H., O'Dell, L. E., Mead, A. N., Coufal, N. G., Parsons, L. H., Tecott, L. H. Enhanced locomotor, reinforcing, and neurochemical effects of cocaine in serotonin 5-hydroxytryptamine 2C receptor mutant mice Journal of Neuroscience 2002 22:10039-10045 PMID:12427861
- Hungund, B. L., Basavarajappa, B. S., Vadasz, C., Kunos, G., de Fonseca, F. R., Colombo, G., Serra, S., Parsons, L., Koob, G. F. Ethanol, endocannabinoids, and the cannabinoidergic signaling system Alcoholism-Clinical and Experimental Research 2002 26:565-574 DOI:10.1111/j.1530-0277.2002.tb02575.x PMID:11981134
- Parsons, L. H., Kerr, T. M., Tecott, L. H. 5-HT(1A) receptor mutant mice exhibit enhanced tonic, stress-induced and fluoxetine-induced serotonergic neurotransmission Journal of Neurochemistry 2001 77:607-617 DOI:10.1046/j.1471-4159.2001.00254.x PMID:11299323
- Weiss, F., Ciccocioppo, R., Parsons, L. H., Katner, S., Liu, X., Zorrilla, E. P., Valdez, G. R., Ben-Shahar, O., Angeletti, S., Richter, R. R. Compulsive drug-seeking behavior and relapse. Neuroadaptation, stress, and conditioning factors Annals of the New York Academy of Sciences 2001 937:1-26 DOI:10.1111/j.1749-6632.2001.tb03556.x PMID:11458532
- Taffe, M. A., Weed, M. R., Davis, S., Huitron-Resendiz, S., Schroeder, R., Parsons, L. H., Henriksen, S. J., Gold, L. H. Functional consequences of repeated (+/-)3,4-methylenedioxymethamphetamine (MDMA) treatment in rhesus monkeys Neuropsychopharmacology 2001 24:230-239 DOI:10.1016/s0893-133x(00)00185-8 PMID:11166514
- Weiss, F., Maldonado-Vlaar, C. S., Parsons, L. H., Kerr, T. M., Smith, D. L., Ben-Shahar, O. Control of cocaine-seeking behavior by drug-associated stimuli in rats: effects on recovery of extinguished operant-responding and extracellular dopamine levels in amygdala and nucleus accumbens Proceedings of the National Academy of Sciences of the United States of America 2000 97:4321-4326 DOI:10.1073/pnas.97.8.4321 PMID:10760299 PMCID:PMC18240
- Solbrig, M. V., Koob, G. F., Parsons, L. H., Kadota, T., Horscroft, N., Briese, T., Lipkin, W. I. Neurotrophic factor expression after CNS viral injury produces enhanced sensitivity to psychostimulants: potential mechanism for addiction vulnerability Journal of Neuroscience 2000 20:RC104 PMID:11050146
- Giuffrida, A., Parsons, L. H., Kerr, T. M., de Fonseca, F. R., Navarro, M., Piomelli, D. Dopamine activation of endogenous cannabinoid signaling in dorsal striatum Nature Neuroscience 1999 2:358-363 DOI:10.1038/7268 PMID:10204543
- Harrison, A. A., Parsons, L. H., Koob, G. F., Markou, A. RU 24969, a 5-HT1A/1B agonist, elevates brain stimulation reward thresholds: an effect reversed by GR 127935, a 5-HT1B/1D antagonist Psychopharmacology 1999 141:242-250 DOI:10.1007/s002130050831 PMID:10027505
- Parsons, L. H., Koob, G. F., Weiss, F. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine Synapse 1999 32:132-135 DOI:10.1002/(sici)1098-2396(199905)32:2<132::aid-syn6>3.0.co;2-v PMID:10231132
- Heisler, L. K., Chu, H. M., Brennan, T. J., Danao, J. A., Bajwa, P., Parsons, L. H., Tecott, L. H. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice Proceedings of the National Academy of Sciences of the United States of America 1998 95:15049-15054 DOI:10.1073/pnas.95.25.15049 PMID:9844013 PMCID:PMC24573
- Koob, G. F., Roberts, A. J., Schulteis, G., Parsons, L. H., Heyser, C. J., Hyytia, P., Merlo-Pich, E., Weiss, F. Neurocircuitry targets in ethanol reward and dependence Alcoholism-Clinical and Experimental Research 1998 22:3-9 DOI:10.1097/00000374-199802000-00001 PMID:9514280
- Parsons, L. H., Weiss, F., Koob, G. F. Serotonin(1B) receptor stimulation enhances cocaine reinforcement Journal of Neuroscience 1998 18:10078-10089 PMID:9822762
- Parsons, L. H., Kerr, T. M., Weiss, F. Simple microbore high-performance liquid chromatographic method for the determination of dopamine and cocaine from a single in vivo brain microdialysis sample Journal of Chromatography B 1998 709:35-45 DOI:10.1016/s0378-4347(98)00024-3 PMID:9653924
- Koob, G. F., Rocio, M., Carrera, A., Gold, L. H., Heyser, C. J., Maldonado-Irizarry, C., Markou, A., Parsons, L. H., Roberts, A. J., Schulteis, G., Stinus, L., Walker, J. R., et al. Substance dependence as a compulsive behavior Journal of Psychopharmacology 1998 12:39-48 DOI:10.1177/026988119801200106 PMID:9584967
- Raber, J., Mehta, P. P., Kreifeldt, M., Parsons, L. H., Weiss, F., Bloom, F. E., Wilson, M. C. Coloboma hyperactive mutant mice exhibit regional and transmitter-specific deficits in neurotransmission Journal of Neurochemistry 1997 68:176-186 DOI:10.1046/j.1471-4159.1997.68010176.x PMID:8978724
- Caine, S. B., Koob, G. F., Parsons, L. H., Everitt, B. J., Schwartz, J. C., Sokoloff, P. D3 receptor test in vitro predicts decreased cocaine self-administration in rats Neuroreport 1997 8:2373-2377 DOI:10.1097/00001756-199707070-00054 PMID:9243643
- Koob, G. F., Caine, S. B., Parsons, L., Markou, A., Weiss, F. Opponent process model and psychostimulant addiction Pharmacology, Biochemistry and Behavior 1997 57:513-521 DOI:10.1016/s0091-3057(96)00438-8 PMID:9218276
- Weiss, F., Parsons, L. H., Schulteis, G., Hyytia, P., Lorang, M. T., Bloom, F. E., Koob, G. F. Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats Journal of Neuroscience 1996 16:3474-3485 PMID:8627380
- Parsons, L. H., Koob, G. F., Weiss, F. Extracellular serotonin is decreased in the nucleus accumbens during withdrawal from cocaine self-administration Behavioural Brain Research 1996 73:225-228 DOI:10.1016/0166-4328(96)00101-5 PMID:8788507
- Parsons, L. H., Caine, S. B., Sokoloff, P., Schwartz, J. C., Koob, G. F., Weiss, F. Neurochemical evidence that postsynaptic nucleus accumbens D3 receptor stimulation enhances cocaine reinforcement Journal of Neurochemistry 1996 67:1078-1089 DOI:10.1046/j.1471-4159.1996.67031078.x PMID:8752115
- Parsons, L. H., Weiss, F., Koob, G. F. Serotonin(1B) receptor stimulation enhances dopamine mediated reinforcement Psychopharmacology 1996 128:150-160 DOI:10.1007/s002130050120 PMID:8956376
- Parsons, L. H., Koob, G. F., Weiss, F. Serotonin dysfunction in the nucleus accumbens of rats during withdrawal after unlimited access to intravenous cocaine Journal of Pharmacology and Experimental Therapeutics 1995 274:1182-1191 PMID:7562486
- Carrera, M. R. A., Ashley, J. A., Parsons, L. H., Wirsching, P., Koob, G. F., Janda, K. D. Suppression of psychoactive effects of cocaine by active immunization Nature 1995 378:727-730 DOI:10.1038/378727a0 PMID:7501020
- Cosford, R. J. O., Parsons, L. H., Justice, J. B. Effect of tetrodotoxin and potassium infusion on microdialysis extraction fraction and extracellular dopamine in the nucleus accumbens Neuroscience Letters 1994 178:175-178 DOI:10.1016/0304-3940(94)90753-6 PMID:7824191
- Parsons, L. H., Justice, J. B. Quantitative approaches to in vivo brain microdialysis Critical Reviews in Neurobiology 1994 8:189-220 PMID:7923396
- Parsons, L. H., Schad, C. A., Justice, J. B. Co-administration of the D2 antagonist pimozide inhibits up-regulation of dopamine release and uptake induced by repeated cocaine Journal of Neurochemistry 1993 60:376-379 DOI:10.1111/j.1471-4159.1993.tb05864.x PMID:8417161
- Parsons, L. H., Justice, J. B. Perfusate serotonin increases extracellular dopamine in the nucleus accumbens as measured by in vivo microdialysis Brain Research 1993 606:195-199 DOI:10.1016/0006-8993(93)90984-u PMID:8490716
- Parsons, L. H., Justice, J. B. Serotonin and dopamine sensitization in the nucleus accumbens, ventral tegmental area, and dorsal raphe nucleus following repeated cocaine administration Journal of Neurochemistry 1993 61:1611-1619 DOI:10.1111/j.1471-4159.1993.tb09794.x PMID:7693863
- Parsons, L. H., Justice, J. B. Extracellular concentration and in vivo recovery of dopamine in the nucleus accumbens using microdialysis Journal of Neurochemistry 1992 58:212-218 DOI:10.1111/j.1471-4159.1992.tb09298.x PMID:1727431
- Parsons, L. H., Smith, A. D., Justice, J. B. Basal extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine Synapse 1991 9:60-65 DOI:10.1002/syn.890090109 PMID:1796352
- Parsons, L. H., Smith, A. D., Justice, J. B. The in vivo microdialysis recovery of dopamine is altered independently of basal level by 6-hydroxydopamine lesions to the nucleus accumbens Journal of Neuroscience Methods 1991 40:139-147 DOI:10.1016/0165-0270(91)90063-6 PMID:1800851
- Pettit, H. O., Pan, H. T., Parsons, L. H., Justice, J. B. Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration Journal of Neurochemistry 1990 55:798-804 DOI:10.1111/j.1471-4159.1990.tb04562.x PMID:2384752

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