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Park, HaJeung
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Park, HaJeung

Non-Faculty Academic
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Positions

  • 2007 - Director, X-Ray Crystallography Core (Florida)
  • 2003 - 2006 Research Fellow, National Institute of Environmental Health Sciences , National Institutes of Health
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Publications

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  • academic article

    • Strutzenberg, T. S., Garcia-Ordonez, R. D., Novick, S. J., Park, H., Chang, M. R., Doebellin, C., He, Y., Patouret, R., Kamenecka, T. M., Griffin, P. R. HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists Elife  2019 8  DOI:10.7554/eLife.47172  PMID:31172947  PMCID:PMC6579513
    • Hwang, D.*, Nilchan, N.*, Nanna, A. R., Li, X., Cameron, M. D., Roush, W. R., Park, H., Rader, C. Site-selective antibody functionalization via orthogonally reactive arginine and lysine residues Cell Chemical Biology  2019 26:1229-1239  DOI:10.1016/j.chembiol.2019.05.010  PMID:31231031  PMCID:PMC6754284 (* = equal contribution)
    • Lee, C. W., Park, S. H., Lee, S. G., Park, H. H., Kim, H. J., Park, H., Park, H., Lee, J. H. Crystal structure of dihydrodipicolinate reductase (PaDHDPR) from Paenisporosarcina sp. TG-14: structural basis for NADPH preference as a cofactor Scientific Reports  2018 8  DOI:10.1038/s41598-018-26291-x  PMID:29786696  PMCID:PMC5962572
    • Qi, J., Li, X., Peng, H., Cook, E. M., Dadashian, E. L., Wiestner, A., Park, H., Rader, C. Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1 Proceedings of the National Academy of Sciences of the United States of America  2018 115:E5467-E5476  DOI:10.1073/pnas.1719905115  PMID:29844189
    • Lee, C. W., Park, S. H., Lee, S. G., Shin, S. C., Han, S. J., Kim, H. W., Park, H. H., Kim, S., Kim, H. J., Park, H., Park, H., Lee, J. H. Crystal structure of the inactive state of the receiver domain of Spo0A from Paenisporosarcina sp TG-14, a psychrophilic bacterium isolated from an Antarctic glacier Journal of Microbiology  2017 55:464-474  DOI:10.1007/s12275-017-6599-9  PMID:28281198
    • Park, H., Tran, T., Lee, J. H., Park, H., Disney, M. D. Controlled dehydration improves the diffraction quality of two RNA crystals BMC Structural Biology  2016 16  DOI:10.1186/s12900-016-0069-1  PMID:27809904  PMCID:PMC5093936
    • Do, H., Lee, C. W., Lee, S. G., Kang, H., Park, C. M., Kim, H. J., Park, H., Park, H., Lee, J. H. Crystal structure and modeling of the tetrahedral intermediate state of methylmalonate-semialdehyde dehydrogenase (MMSDH) from Oceanimonas doudoroffii Journal of Microbiology  2016 54:114-121  DOI:10.1007/s12275-016-5549-2  PMID:26832667
    • Yin, Y., Zheng, K., Eid, N., Howard, S., Jeong, J. H., Yi, F., Guo, J., Park, C. M., Bibian, M., Wu, W., Hernandez, P., Park, H., et al. Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors Journal of Medicinal Chemistry  2015 58:1846-1861  DOI:10.1021/jm501680m  PMID:25621531  PMCID:PMC4349585
    • Hackwon, D., Kim, S. J., Lee, C. W., Kim, H. W., Park, H. H., Kim, H. M., Park, H., Park, H., Lee, J. H. Crystal structure of UbiX, an aromatic acid decarboxylase from the psychrophilic bacterium Colwellia psychrerythraea that undergoes FMN-induced conformational changes Scientific Reports  2015 5:8196  DOI:10.1038/srep08196  PMID:25645665  PMCID:PMC4316190
    • Marciano, D. P., Kuruvilla, D. S., Boregowda, S. V., Asteian, A., Hughes, T. S., Garcia-Ordonez, R., Corzo, C. A., Khan, T. M., Novick, S. J., Park, H., Kojetin, D. J., Phinney, D. G., et al. Pharmacological repression of PPARγ promotes osteogenesis Nature Communications  2015 6:7443  DOI:10.1038/ncomms8443  PMID:26068133  PMCID:PMC4471882
    • Zheng, K., Park, C. M., Iqbal, S., Hernandez, P., Park, H., Lograsso, P. V., Feng, Y. Pyridopyrimidinone derivatives as potent and selective c-jun N-terminal kinase (JNK) inhibitors ACS Medicinal Chemistry Letters  2015 6:413-418  DOI:10.1021/ml500474d  PMID:25893042  PMCID:PMC4394340
    • Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P. Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles Scientific Reports  2015 5  DOI:10.1038/srep08047  PMID:25623238  PMCID:PMC4306959
    • Rzuczek, S. G., Park, H., Disney, M. D. A toxic RNA catalyzes the in cellulo synthesis of its own inhibitor Angewandte Chemie-International Edition  2014 53:10956-10959  DOI:10.1002/anie.201406465  PMID:25164984
    • Zheng, K., Iqbal, S., Hernandez, P., Park, H., Lograsso, P. V., Feng, Y. Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives Journal of Medicinal Chemistry  2014 57:10013-10030  DOI:10.1021/jm501256y  PMID:25393557  PMCID:PMC4266361
    • Lee, J. H., Park, H., Park, Y. H. Molecular mechanisms of host cytoskeletal rearrangements by Shigella invasins International Journal of Molecular Sciences  2014 15:18253-18266  DOI:10.3390/ijms151018253  PMID:25310650  PMCID:PMC4227214
    • Childs-Disney, J. L., Yildirim, I., Park, H., Lohman, J. R., Guan, L., Tran, T., Sarkar, P., Schatz, G. C., Disney, M. D. Structure of the myotonic dystrophy type 2 RNA and designed small molecules that reduce toxicity ACS Chemical Biology  2014 9:538-550  DOI:10.1021/cb4007387  PMID:24341895  PMCID:PMC3944380
    • Yildirim, I., Park, H., Disney, M. D., Schatz, G. C. A dynamic structural model of expanded RNA CAG repeats: A refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations Journal of the American Chemical Society  2013 135:3528-3538  DOI:10.1021/ja3108627  PMID:23441937  PMCID:PMC3625063
    • Feng, Y. B., Chambers, J. W., Iqbal, S., Koenig, M., Park, H., Cherry, L., Hernandez, P., Figuera-Losada, M., Lograsso, P. V. A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases ACS Chemical Biology  2013 8:1747-1754  DOI:10.1021/cb3006165  PMID:23751758  PMCID:PMC3759981
    • Feng, Y., Chambers, J. W., Iqbal, S., Koenig, M., Park, H., Cherry, L., Hernandez, P., Figuera-Losada, M., Lograsso, P. V. A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases ACS Chemical Biology  2013 8:1747-1754  DOI:10.1021/cb3006165  PMID:23751758  PMCID:PMC3759981
    • Mueller, G. A., Maleki, S. J., Johnson, K., Hurlburt, B. K., Cheng, H., Ruan, S., Nesbit, J. B., Pomes, A., Edwards, L. L., Schorzman, A., Deterding, L. J., Park, H., et al. Identification of Maillard reaction products on peanut allergens that influence binding to the receptor for advanced glycation end products Allergy  2013 68:1546-1554  DOI:10.1111/all.12261  PMID:24266677  PMCID:PMC3915869
    • Childs-Disney, J. L., Stepniak-Konieczna, E., Tran, T., Yildirim, I., Park, H., Chen, C. Z., Hoskins, J., Southall, N., Marugan, J. J., Patnaik, S., Zheng, W., Austin, C. P., et al. Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules Nature Communications  2013 4:2044  DOI:10.1038/ncomms3044  PMID:23806903  PMCID:PMC3710115
    • Yin, Y., Lin, L., Ruiz, C., Khan, S., Cameron, M. D., Grant, W., Pocas, J., Eid, N., Park, H., Schroter, T., Lograsso, P. V., Feng, Y. Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors Journal of Medicinal Chemistry  2013 56:3568-3581  DOI:10.1021/jm400062r  PMID:23570561
  • thesis

    • Structural studies of two heme proteins and a UV-damaged DNA, and polymerization study of canine cardiac calsequestrin 2002

featured in

  • Scripps Florida Scientists Uncover Most Detailed Picture Yet of Muscular Dystrophy Defect then Design Targeted New Drug Candidates  News Release
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Background

education and training

  • Ph.D. in Biochemistry, Washington State University 1998 - 2002
  • M.V.Sc. in Microbiology and Immunology, Seoul National University 1997 - 1999
  • D.V.M., Gyeongsang National University 1990 - 1996
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Contact

full name

  • HaJeung Park

geographic location

  • Scripps Florida 

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