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Page, Damon
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Page, Damon

Faculty Member
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Positions

  • 2016 - Associate Professor, Neuroscience , Scripps Research
  • 2011 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2011 - 2016 Assistant Professor, Neuroscience , Scripps Research
  • 2010 - 2011 Senior Analyst, Allen Institute for Brain Science

Research Areas research areas

  • Mental Illness (UMLS)

Contact

  • paged@scripps.edu

Websites

  • Damon Page, Ph.D.
  • Laboratory Website
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  • Research
  • Teaching
  • Background
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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Xu, Z. X., Kim, G. H., Tan, J. W., Riso, A. E., Sun, Y., Xu, E. Y., Liao, G. Y., Xu, H. F., Lee, S. H., Do, N. Y., Lee, C. H., Clipperton-Allen, A. E., et al. Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations Nature Communications  2020 11  DOI:10.1038/s41467-020-15530-3  PMID:32286273  PMCID:PMC7156673
    • Clipperton-Allen, A. E., Page, D. T. Connecting Genotype with Behavioral Phenotype in Mouse Models of Autism Associated with PTEN Mutations Cold Spring Harbor Perspectives in Medicine  2020 10  DOI:10.1101/cshperspect.a037010  PMID:31871231  PMCID:PMC7461765
    • Clipperton-Allen, A. E., Cohen, O. S., Aceti, M., Zucca, A., Levy, J., Ellegood, J., Lerch, J. P., Page, D. T. Pten haploinsufficiency disrupts scaling across brain areas during development in mice Translational Psychiatry  2019 9  DOI:10.1038/s41398-019-0656-6  PMID:31804455  PMCID:PMC6895202
    • Huang, W. C., Chen, Y., Page, D. T. Genetic suppression of mTOR rescues synaptic and social behavioral abnormalities in a mouse model of Pten haploinsufficiency Autism Research  2019  DOI:10.1002/aur.2186  PMID:31441226
    • Shahani, N., Huang, W. C., Varnum, M., Page, D., Subramaniam, S. Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice Neurobiology of Aging  2017 50:134-143  DOI:10.1016/j.neurobiolaging.2016.11.006  PMID:27960107  PMCID:PMC5209246
    • Clipperton-Allen, A. E., Chen, Y., Page, D. T. Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons Autism Research  2016 9:1248-1262  DOI:10.1002/aur.1641  PMID:27220363
    • Huang, W. C., Chen, Y., Page, D. T. Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome Nature Communications  2016 7  DOI:10.1038/ncomms13421  PMID:27845329
    • Huang, W. C., Abraham, R., Shim, B. S., Choe, H., Page, D. T. Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice Scientific Reports  2016 6  DOI:10.1038/srep34793  PMID:27713505  PMCID:PMC5054421
    • Swarnkar, S., Chen, Y., Pryor, W. M., Shahani, N., Page, D. T., Subramaniam, S. Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease Neurobiology of Disease  2015 82:66-77  DOI:10.1016/j.nbd.2015.05.011  PMID:26048156
    • Séjourné, J., Llaneza, D., Kuti, O. J., Page, D. T. Social behavioral deficits coincide with the onset of seizure susceptibility in mice lacking serotonin receptor 2c PLoS One  2015 10:e0136494  DOI:10.1371/journal.pone.0136494  PMID:26308619  PMCID:PMC4550412
    • Chen, Y., Huang, W. C., Sejourne, J., Clipperton-Allen, A. E., Page, D. T. Pten mutations alter brain growth trajectory and allocation of cell types through elevated β-catenin signaling Journal of Neuroscience  2015 35:10252-10267  DOI:10.1523/jneurosci.5272-14.2015  PMID:26180201
    • Clipperton-Allen, A. E., Page, D. T. Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice Genes Brain and Behavior  2015 14:145-157  DOI:10.1111/gbb.12192  PMID:25561290
    • Creson, T. K., Vaissiere, T., Rojas, C., Huang, W. C., Wang, Y. X., Petralia, R. S., Page, D. T., Miller, C. A., Rumbaugh, G. Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly Biological Psychiatry  2015 77:805-815  DOI:10.1016/j.biopsych.2014.08.001  PMID:25444158  PMCID:PMC4326604
    • Pryor, W. M., Biagioli, M., Shahani, N., Swarnkar, S., Huang, W. C., Page, D. T., MacDonald, M. E., Subramaniam, S. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease Science Signaling  2014 7  DOI:10.1126/scisignal.2005633  PMID:25351248
    • Thompson, C. L., Ng, L., Menon, V., Martinez, S., Lee, C. K., Glattfelder, K., Sunkin, S. M., Henry, A., Lau, C., Dang, C., Garcia-Lopez, R., Martinez-Ferre, A., et al. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain Neuron  2014 83:309-323  DOI:10.1016/j.neuron.2014.05.033  PMID:24952961  PMCID:PMC4319559
    • Clipperton-Allen, A. E., Page, D. T. Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests Human Molecular Genetics  2014 23:3490-3505  DOI:10.1093/hmg/ddu057  PMID:24497577
    • Zeng, H. K., Shen, E. H., Hohmann, J. G., Oh, S. W., Bernard, A., Royall, J. J., Glattfelder, K. J., Sunkin, S. M., Morris, J. A., Guillozet-Bongaarts, A. L., Smith, K. A., Ebbert, A. J., et al. Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures Cell  2012 149:483-496  DOI:10.1016/j.cell.2012.02.052  PMID:22500809  PMCID:PMC3328777
    • Hawrylycz, M., Ng, L., Page, D., Morris, J., Lau, C., Faber, S., Faber, V., Sunkin, S., Menon, V., Lein, E., Jones, A. Multi-scale correlation structure of gene expression in the brain Neural Networks  2011 24:933-942  DOI:10.1016/j.neunet.2011.06.012  PMID:21764550
    • Page, D. T. A candidate circuit approach to investigating autism Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology  2011 294:1671-1684  DOI:10.1002/ar.21473  PMID:22026018
    • Horng, S., Kreiman, G., Ellsworth, C., Page, D., Blank, M., Millen, K., Sur, M. Differential gene expression in the developing lateral geniculate nucleus and medial geniculate nucleus reveals novel roles for Zic4 and Foxp2 in visual and auditory pathway development Journal of Neuroscience  2009 29:13672-13683  DOI:10.1523/jneurosci.2127-09.2009  PMID:19864579  PMCID:PMC3395072
    • Mao, R., Page, D. T., Merzlyak, I., Kim, C., Tecott, L. H., Janak, P. H., Rubenstein, J. L. R., Sur, M. Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons Journal of Neurodevelopmental Disorders  2009 1:224-236  DOI:10.1007/s11689-009-9025-8  PMID:19816534  PMCID:PMC2758250
    • Page, D. T., Kuti, O. J., Prestia, C., Sur, M. Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior Proceedings of the National Academy of Sciences of the United States of America  2009 106:1989-1994  DOI:10.1073/pnas.0804428106  PMID:19208814  PMCID:PMC2644151
    • Page, D. T., Kuti, O. J., Sur, M. Computerized assessment of social approach behavior in mouse Frontiers in Behavioral Neuroscience  2009 3:48  DOI:10.3389/neuro.08.048.2009  PMID:20198104  PMCID:PMC2802322
    • Page, D. T., Olofsson, B. Multiple roles for apoptosis facilitating condensation of the Drosophila ventral nerve cord Genesis  2008 46:61-68  DOI:10.1002/dvg.20365  PMID:18257102
    • Olofsson, B., Page, D. T. Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity Developmental Biology  2005 279:233-243  DOI:10.1016/j.ydbio.2004.12.020  PMID:15708571
    • Page, D. T. A mode of arthropod brain evolution suggested by Drosophila commissure development Evolution & Development  2004 6:25-31  DOI:10.1111/j.1525-142X.2004.04003.x  PMID:15108815
    • Page, D. T. A function for Egf receptor signaling in expanding the developing brain in Drosophila Current Biology  2003 13:474-482  DOI:10.1016/s0960-9822(03)00094-0  PMID:12646129
    • Page, D. T. Inductive patterning of the embryonic brain in Drosophila Development  2002 129:2121-2128  PMID:11959822
    • Page, D. T. labial acts to initiate neuronal fate specification, but not axon pathfinding, in the embryonic brain of Drosophila Development Genes and Evolution  2000 210:559-563  DOI:10.1007/s004270000097  PMID:11180806
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Research

research overview

  • My laboratory is focused on understanding how the components necessary for establishing the cellular architecture of the brain (neuronal and glial cell types) are generated and how these assemble into functional circuits that underlie behavior. The mechanisms by which these processes occur are largely unknown, and yet, disruptions can have enormous societal and personal consequences in the form of neurodevelopmental and neuropsychiatric disorders. Such disorders provide a window into the basic genetic and cellular mechanisms involved in building the brain. This insight may be used in turn to benefit those affected by mental illness, pointing to molecular targets for improved diagnostics and therapeutics.

    Autism spectrum disorder (ASD) is one such disorder. ASD is characterized by a range of phenotypes, including deficits in social behavior, as well as an altered trajectory of brain growth in some cases. Clues to mechanisms come from reports that PTEN-PI3K-mTOR, monoamine, neuropeptide and synaptic signaling pathways have been implicated in ASD pathogenesis. Understanding how these risk factors influence brain and behavior will give us basic insight into how the brain develops and how this process is altered in ASD.

    Along these lines, my laboratory makes use of transgenic and knockout mice to understand the biology of how risk factors for autism and related neurodevelopmental disorders influence the development of cell types and circuits underlying behavior, and to test efficacy of potential therapeutics. The PTEN-PI3K-mTOR pathway and neural systems relevant for autism and social behavior (e.g. serotonin and oxytocin/vasopressin) are areas of focus for our work.

    We use a variety of techniques, including transgenic mice, histology, molecular cell biology, genomics, informatics, pharmacology, imaging and behavioral phenotyping.

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Teaching

advisees

  • graduate advising relationship

    • Levy, Jenna, Ph.D.  candidate, 2017 -
    • Huang, Wen-Chin, Ph.D.  candidate, 2013 - 2017
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Background

education and training

  • Massachusetts Institute of Technology , Research Fellow 2004 - 2010
  • University of Cambridge , MRC Laboratory of Molecular Biology, Research Fellow 2002 - 2004
  • Ph.D., University of Cambridge , Medical Research Council Laboratory of Molecular Biology 2002
  • B.S. in Biology, Eastern Oregon University 1999
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Contact

full name

  • Damon T. Page

geographic location

  • Scripps Florida 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0002-2687-1563

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