recent publications
-
academic article
- Xu, Z. X., Kim, G. H., Tan, J. W., Riso, A. E., Sun, Y., Xu, E. Y., Liao, G. Y., Xu, H. F., Lee, S. H., Do, N. Y., Lee, C. H., Clipperton-Allen, A. E., et al. Elevated protein synthesis in microglia causes autism-like synaptic and behavioral aberrations Nature Communications 2020 11 DOI:10.1038/s41467-020-15530-3 PMID:32286273 PMCID:PMC7156673
- Clipperton-Allen, A. E., Page, D. T. Connecting Genotype with Behavioral Phenotype in Mouse Models of Autism Associated with PTEN Mutations Cold Spring Harbor Perspectives in Medicine 2020 10 DOI:10.1101/cshperspect.a037010 PMID:31871231 PMCID:PMC7461765
- Clipperton-Allen, A. E., Cohen, O. S., Aceti, M., Zucca, A., Levy, J., Ellegood, J., Lerch, J. P., Page, D. T. Pten haploinsufficiency disrupts scaling across brain areas during development in mice Translational Psychiatry 2019 9 DOI:10.1038/s41398-019-0656-6 PMID:31804455 PMCID:PMC6895202
- Huang, W. C., Chen, Y., Page, D. T. Genetic suppression of mTOR rescues synaptic and social behavioral abnormalities in a mouse model of Pten haploinsufficiency Autism Research 2019 DOI:10.1002/aur.2186 PMID:31441226
- Shahani, N., Huang, W. C., Varnum, M., Page, D., Subramaniam, S. Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice Neurobiology of Aging 2017 50:134-143 DOI:10.1016/j.neurobiolaging.2016.11.006 PMID:27960107 PMCID:PMC5209246
- Clipperton-Allen, A. E., Chen, Y., Page, D. T. Autism-relevant behaviors are minimally impacted by conditional deletion of Pten in oxytocinergic neurons Autism Research 2016 9:1248-1262 DOI:10.1002/aur.1641 PMID:27220363
- Huang, W. C., Chen, Y., Page, D. T. Hyperconnectivity of prefrontal cortex to amygdala projections in a mouse model of macrocephaly/autism syndrome Nature Communications 2016 7 DOI:10.1038/ncomms13421 PMID:27845329
- Huang, W. C., Abraham, R., Shim, B. S., Choe, H., Page, D. T. Zika virus infection during the period of maximal brain growth causes microcephaly and corticospinal neuron apoptosis in wild type mice Scientific Reports 2016 6 DOI:10.1038/srep34793 PMID:27713505 PMCID:PMC5054421
- Swarnkar, S., Chen, Y., Pryor, W. M., Shahani, N., Page, D. T., Subramaniam, S. Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease Neurobiology of Disease 2015 82:66-77 DOI:10.1016/j.nbd.2015.05.011 PMID:26048156
- Séjourné, J., Llaneza, D., Kuti, O. J., Page, D. T. Social behavioral deficits coincide with the onset of seizure susceptibility in mice lacking serotonin receptor 2c PLoS One 2015 10:e0136494 DOI:10.1371/journal.pone.0136494 PMID:26308619 PMCID:PMC4550412
- Chen, Y., Huang, W. C., Sejourne, J., Clipperton-Allen, A. E., Page, D. T. Pten mutations alter brain growth trajectory and allocation of cell types through elevated β-catenin signaling Journal of Neuroscience 2015 35:10252-10267 DOI:10.1523/jneurosci.5272-14.2015 PMID:26180201
- Clipperton-Allen, A. E., Page, D. T. Decreased aggression and increased repetitive behavior in Pten haploinsufficient mice Genes Brain and Behavior 2015 14:145-157 DOI:10.1111/gbb.12192 PMID:25561290
- Creson, T. K., Vaissiere, T., Rojas, C., Huang, W. C., Wang, Y. X., Petralia, R. S., Page, D. T., Miller, C. A., Rumbaugh, G. Syngap1 haploinsufficiency damages a postnatal critical period of pyramidal cell structural maturation linked to cortical circuit assembly Biological Psychiatry 2015 77:805-815 DOI:10.1016/j.biopsych.2014.08.001 PMID:25444158 PMCID:PMC4326604
- Pryor, W. M., Biagioli, M., Shahani, N., Swarnkar, S., Huang, W. C., Page, D. T., MacDonald, M. E., Subramaniam, S. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease Science Signaling 2014 7 DOI:10.1126/scisignal.2005633 PMID:25351248
- Thompson, C. L., Ng, L., Menon, V., Martinez, S., Lee, C. K., Glattfelder, K., Sunkin, S. M., Henry, A., Lau, C., Dang, C., Garcia-Lopez, R., Martinez-Ferre, A., et al. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain Neuron 2014 83:309-323 DOI:10.1016/j.neuron.2014.05.033 PMID:24952961 PMCID:PMC4319559
- Clipperton-Allen, A. E., Page, D. T. Pten haploinsufficient mice show broad brain overgrowth but selective impairments in autism-relevant behavioral tests Human Molecular Genetics 2014 23:3490-3505 DOI:10.1093/hmg/ddu057 PMID:24497577
- Zeng, H. K., Shen, E. H., Hohmann, J. G., Oh, S. W., Bernard, A., Royall, J. J., Glattfelder, K. J., Sunkin, S. M., Morris, J. A., Guillozet-Bongaarts, A. L., Smith, K. A., Ebbert, A. J., et al. Large-scale cellular-resolution gene profiling in human neocortex reveals species-specific molecular signatures Cell 2012 149:483-496 DOI:10.1016/j.cell.2012.02.052 PMID:22500809 PMCID:PMC3328777
- Hawrylycz, M., Ng, L., Page, D., Morris, J., Lau, C., Faber, S., Faber, V., Sunkin, S., Menon, V., Lein, E., Jones, A. Multi-scale correlation structure of gene expression in the brain Neural Networks 2011 24:933-942 DOI:10.1016/j.neunet.2011.06.012 PMID:21764550
- Page, D. T. A candidate circuit approach to investigating autism Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology 2011 294:1671-1684 DOI:10.1002/ar.21473 PMID:22026018
- Horng, S., Kreiman, G., Ellsworth, C., Page, D., Blank, M., Millen, K., Sur, M. Differential gene expression in the developing lateral geniculate nucleus and medial geniculate nucleus reveals novel roles for Zic4 and Foxp2 in visual and auditory pathway development Journal of Neuroscience 2009 29:13672-13683 DOI:10.1523/jneurosci.2127-09.2009 PMID:19864579 PMCID:PMC3395072
- Mao, R., Page, D. T., Merzlyak, I., Kim, C., Tecott, L. H., Janak, P. H., Rubenstein, J. L. R., Sur, M. Reduced conditioned fear response in mice that lack Dlx1 and show subtype-specific loss of interneurons Journal of Neurodevelopmental Disorders 2009 1:224-236 DOI:10.1007/s11689-009-9025-8 PMID:19816534 PMCID:PMC2758250
- Page, D. T., Kuti, O. J., Prestia, C., Sur, M. Haploinsufficiency for Pten and Serotonin transporter cooperatively influences brain size and social behavior Proceedings of the National Academy of Sciences of the United States of America 2009 106:1989-1994 DOI:10.1073/pnas.0804428106 PMID:19208814 PMCID:PMC2644151
- Page, D. T., Kuti, O. J., Sur, M. Computerized assessment of social approach behavior in mouse Frontiers in Behavioral Neuroscience 2009 3:48 DOI:10.3389/neuro.08.048.2009 PMID:20198104 PMCID:PMC2802322
- Page, D. T., Olofsson, B. Multiple roles for apoptosis facilitating condensation of the Drosophila ventral nerve cord Genesis 2008 46:61-68 DOI:10.1002/dvg.20365 PMID:18257102
- Olofsson, B., Page, D. T. Condensation of the central nervous system in embryonic Drosophila is inhibited by blocking hemocyte migration or neural activity Developmental Biology 2005 279:233-243 DOI:10.1016/j.ydbio.2004.12.020 PMID:15708571
- Page, D. T. A mode of arthropod brain evolution suggested by Drosophila commissure development Evolution & Development 2004 6:25-31 DOI:10.1111/j.1525-142X.2004.04003.x PMID:15108815
- Page, D. T. A function for Egf receptor signaling in expanding the developing brain in Drosophila Current Biology 2003 13:474-482 DOI:10.1016/s0960-9822(03)00094-0 PMID:12646129
- Page, D. T. Inductive patterning of the embryonic brain in Drosophila Development 2002 129:2121-2128 PMID:11959822
- Page, D. T. labial acts to initiate neuronal fate specification, but not axon pathfinding, in the embryonic brain of Drosophila Development Genes and Evolution 2000 210:559-563 DOI:10.1007/s004270000097 PMID:11180806