Oldstone, Michael

Faculty Member

Positions

Professor, Immunology and Microbiology , The Scripps Research Institute 2017 -
Resident Scholar (Professor), The University of Alabama (Tuscaloosa) , The University of Alabama System 2007 -
Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , The Scripps Research Institute 1997 -
Head, Viral-Immunobiology Laboratory, The Scripps Research Institute 1989 -
Head: Pathogenesis (Virology) Affinity Group, The Scripps Research Institute 1987 -
Adjunct Professor, Department of Neurosciences, School of Medicine, University of California, San Diego 1978 -
Member, Department of Immunology, Scripps Clinic and Research Foundation 1977 -
Professor, Immunology and Microbial Science (IMS) , The Scripps Research Institute 2008 - 2017
Adjunct Professor of Virology, Department of Infectology, Scripps Florida , The Scripps Research Institute 2004 - 2017
Professor, Molecular and Integrative Neurosciences (MIND) , The Scripps Research Institute 1989 - 2008
Associate Member, Department of Immunopathology, Scripps Clinic and Research Foundation 1972 - 1976
Assistant Member, Department of Experimental Pathology,, Scripps Clinic and Research Foundation 1969 - 1971

Dr. Michael Oldstone studies the interaction of viruses and the immune system, how viruses persist and the resultant disease, how a non-lytic virus alters the differentiation function of the infected cell, investigates infectious protein folding disease and uses transgenic mouse models to understand human diseases. Included are molecular explorations for how viruses suppress the immune system or on the other side of the coin, induce autoimmunity.

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Michael B.A. Oldstone, M.D.

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academic article
- Smelkinson, M. G., Guichard, A., Teijaro, J. R., Malur, M., Loureiro, M. E., Jain, P., Ganesan, S., Zuniga, E. I., Krug, R. M., Oldstone, M. B., Bier, E. Influenza NS1 directly modulates Hedgehog signaling during infection PLoS Pathogens 2017 13 DOI:10.1371/journal.ppat.1006588 PMID:28837667
- Marro, B. S., Ware, B. C., Zak, J., de la Torre, J. C., Rosen, H., Oldstone, M. B. A. Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling Proceedings of the National Academy of Sciences of the United States of America 2017 114:3708-3713 DOI:10.1073/pnas.1700878114 PMID:28325871 PMCID:PMC5389329
- Ng, C. T., Mendoza, J. L., Garcia, K. C. Alpha and beta type 1 interferon signaling: passage for diverse biologic outcomes Cell 2016 164:349-352 DOI:10.1016/j.cell.2015.12.027 PMID:26824652 PMCID:PMC4733246
- Goba, A., Khan, S. H., Fonnie, M., Fullah, M., Moigboi, A., Kovoma, A., Sinnah, V., Yoko, N., Rogers, H., Safai, S., Momoh, M., Koroma, V., et al. An outbreak of Ebola virus disease in the Lassa fever zone Journal of Infectious Diseases 2016 214:S110-S121 DOI:10.1093/infdis/jiw239 PMID:27402779 PMCID:PMC5050470
- Hastie, K. M., Igonet, S., Sullivan, B. M., Legrand, P., Zandonatti, M. A., Robinson, J. E., Garry, R. F., Rey, F. A., Oldstone, M. B., Saphire, E. O. Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV Nature Structural & Molecular Biology 2016 23:513-521 DOI:10.1038/nsmb.3210 PMID:27111888 PMCID:PMC4945123
- Teijaro, J. R., Studer, S., Leaf, N., Kiosses, W. B., Nguyen, N., Matsuki, K., Negishi, H., Taniguchi, T., Oldstone, M. B. A., Rosen, H. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-alpha autoamplification Proceedings of the National Academy of Sciences of the United States of America 2016 113:1351-1356 DOI:10.1073/pnas.1525356113 PMID:26787880 PMCID:PMC4747766
- Oldstone, M. B. A. The Anatomy of a Career in Science DNA and Cell Biology 2016 35:109-117 PMID:26836569
- Oldstone, M. B. A. A Jekyll and Hyde profile: Type 1 interferon signaling plays a prominent role in the initiation and maintenance of a persistent virus infection Journal of Infectious Diseases 2015 212:S31-S36 DOI:10.1093/infdis/jiu501 PMID:26116728 PMCID:PMC4574552
- Ng, C. T., Sullivan, B. M., Teijaro, J. R., Lee, A. M., Welch, M., Rice, S., Sheehan, K. C. F., Schreiber, R. D., Oldstone, M. B. A. Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection Cell Host & Microbe 2015 17:653-661 DOI:10.1016/j.chom.2015.04.005 PMID:25974304 PMCID:PMC4432251
- Sullivan, B. M., Teijaro, J. R., de la Torre, J. C., Oldstone, M. B. A. Early virus-host interactions dictate the course of a persistent infection PLoS Pathogens 2015 11 DOI:10.1371/journal.ppat.1004588 PMID:25569216 PMCID:PMC4287607
- Siggs, O. M., Popkin, D. L., Krebs, P., Li, X., Tang, M., Zhan, X., Zeng, M., Lin, P., Xia, Y., Oldstone, M. B. A., Cornall, R. J., Beutler, B. Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection Proceedings of the National Academy of Sciences of the United States of America 2015 112:E5706-E5714 DOI:10.1073/pnas.1515619112 PMID:26438836 PMCID:PMC4620900
- Walsh, K. B., Teijaro, J. R., Brock, L. G., Fremgen, D. M., Collins, P. L., Rosen, H., Oldstone, M. B. A. Animal model of respiratory syncytial virus: CD8(+) T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy Journal of Virology 2014 88:6281-6293 DOI:10.1128/jvi.00464-14 PMID:24672024
- Oldstone, M. B. A., Rosen, H. Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule Current Topics in Microbiology and Immunology 2014 378:129-147 DOI:10.1007/978-3-319-05879-5_6 PMID:24728596
- Ng, C. T., Oldstone, M. B. A. IL-10: achieving balance during persistent viral infection Current Topics in Microbiology and Immunology 2014 380:129-144 DOI:10.1007/978-3-662-43492-5_6 PMID:25004816
- Teijaro, J. R., Walsh, K. B., Rice, S., Rosen, H., Oldstone, M. B. A. Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection Proceedings of the National Academy of Sciences of the United States of America 2014 111:3799-3804 DOI:10.1073/pnas.1400593111 PMID:24572573 PMCID:PMC3956176
- Teijaro, J. R., Walsh, K. B., Long, J. P., Tordoff, K. P., Stark, G. V., Eisfeld, A. J., Kawaoka, Y., Rosen, H., Oldstone, M. B. A. Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy Virology 2014 452:152-157 DOI:10.1016/j.virol.2014.01.003 PMID:24606692 PMCID:PMC3954990
- Baccala, R., Welch, M. J., Gonzalez-Quintial, R., Walsh, K. B., Teijaro, J. R., Nguyen, A., Ng, C. T., Sullivan, B. M., Zarpellon, A., Ruggeri, Z. M., de la Torre, J. C., Theofilopoulos, A. N., et al. Type I interferon is a therapeutic target for virus-induced lethal vascular damage Proceedings of the National Academy of Sciences of the United States of America 2014 111:8925-8930 DOI:10.1073/pnas.1408148111 PMID:24889626 PMCID:PMC4066519
- Walsh, K. B., Sidney, J., Welch, M., Fremgen, D. M., Sette, A., Oldstone, M. B. A. CD8(+) T-Cell Epitope Mapping for Pneumonia Virus of Mice in H-2(b) Mice Journal of Virology 2013 87:9949-9952 DOI:10.1128/jvi.00339-13 PMID:23824814 PMCID:PMC3754129
- Bett, C., Kurt, T. D., Lucero, M., Trejo, M., Rozemuller, A. J., Kong, Q. Z., Nilsson, K. P. R., Masliah, E., Oldstone, M. B., Sigurdson, C. J. Defining the conformational features of anchorless, poorly neuroinvasive prions PLoS Pathogens 2013 9:e1003280 DOI:10.1371/journal.ppat.1003280 PMID:23637596 PMCID:PMC3630170
- Oldstone, M. B. A., Teijaro, J. R., Walsh, K. B., Rosen, H. Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection Virology 2013 435:92-101 DOI:10.1016/j.virol.2012.09.039 PMID:23217619 PMCID:PMC3523270
- Sullivan, B. M., Welch, M. J., Lemke, G., Oldstone, M. B. A. Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus? Journal of Virology 2013 87:4071-4074 DOI:10.1128/jvi.03268-12 PMID:23325690 PMCID:PMC3624193
- Priola, S. A., Ward, A. E., McCall, S. A., Trifilo, M., Choi, Y. P., Solforosi, L., Williamson, R. A., Cruite, J. T., Oldstone, M. B. A. Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease Journal of Virology 2013 87:9501-9510 DOI:10.1128/jvi.00692-13 PMID:23785217 PMCID:PMC3754135
- Oldstone, M. B. A. Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza Proceedings of the National Academy of Sciences of the United States of America 2013 110:42-45 DOI:10.1073/pnas.1222025110 PMID:23341590 PMCID:PMC3600446
- Kang, S. G., Liu, W. H., Lu, P., Jin, H. Y., Lim, H. W., Shepherd, J., Fremgen, D., Verdin, E., Oldstone, M. B. A., Qi, H., Teijaro, J. R., Xiao, C. MicroRNAs of the miR-17 similar to 92 family are critical regulators of T-FH differentiation Nature Immunology 2013 14:849-857 DOI:10.1038/ni.2648 PMID:23812097 PMCID:PMC3740954
- Chabot, S., Fakhfakh, A., Beland, K., Lamarre, A., Oldstone, M. B. A., Alvarez, F., Djilali-Saiah, I. Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes Journal of Autoimmunity 2013 42:19-28 DOI:10.1016/j.jaut.2012.10.002 PMID:23137675 PMCID:PMC4465814
- Ng, C. T., Snell, L. M., Brooks, D. G., Oldstone, M. B. A. Networking at the level of host immunity: immune cell interactions during persistent viral infections Cell Host & Microbe 2013 13:652-664 DOI:10.1016/j.chom.2013.05.014 PMID:23768490 PMCID:PMC3713852
- Lee, A. M., Cruite, J., Welch, M. J., Sullivan, B., Oldstone, M. B. A. Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus Virology 2013 442:114-121 DOI:10.1016/j.virol.2013.04.010 PMID:23684417 PMCID:PMC3686847
- Teijaro, J. R., Ng, C., Lee, A. M., Sullivan, B. M., Sheehan, K. C. F., Welch, M., Schreiber, R. D., de la Torre, J. C., Oldstone, M. B. A. Persistent LCMV infection is controlled by blockade of type I interferon signaling Science 2013 340:207-211 DOI:10.1126/science.1235214 PMID:23580529 PMCID:PMC3640797
- Rosen, H., Stevens, R. C., Hanson, M., Roberts, E., Oldstone, M. B. A. Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence Annual Review of Biochemistry 2013 82:637-662 DOI:10.1146/annurev-biochem-062411-130916 PMID:23527695
- Burri, D. J., Pasquato, A., da Palma, J. R., Igonet, S., Oldstone, M. B. A., Kunz, S. The role of proteolytic processing and the stable signal peptide in expression of the old world arenavirus envelope glycoprotein ectodomain Virology 2013 436:127-133 DOI:10.1016/j.virol.2012.10.038 PMID:23218200 PMCID:PMC3545064
- Matheu, M. P., Teijaro, J. R., Walsh, K. B., Greenberg, M. L., Marsolais, D., Parker, I., Rosen, H., Oldstone, M. B. A., Cahalan, M. D. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy PLoS One 2013 8:e58033 DOI:10.1371/journal.pone.0058033 PMID:23533579 PMCID:PMC3606384
- Welch, M. J., Teijaro, J. R., Lewicki, H. A., Colonna, M., Oldstone, M. B. A. CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection. Virology 2012 429:163-170 DOI:10.1016/j.virol.2012.04.006 PMID:22579352 PMCID:PMC3571684
- Siggs, O. M., Cruite, J. T., Du, X., Rutschmann, S., Masliah, E., Beutler, B., Oldstone, M. B. A. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease Proceedings of the National Academy of Sciences of the United States of America 2012 109:13733-13738 DOI:10.1073/pnas.1211499109 PMID:22869751 PMCID:PMC3427069
- Ng, C. T., Nayak, B. P., Schmedt, C., Oldstone, M. B. A. Immortalized clones of fibroblastic reticular cells activate virus-specific t cells during virus infection Proceedings of the National Academy of Sciences of the United States of America 2012 109:7823-7828 DOI:10.1073/pnas.1205850109 PMID:22550183 PMCID:PMC3356638
- Ng, C. T., Oldstone, M. B. A. Infected cd8 alpha(-) dendritic cells are the predominant source of il-10 during establishment of persistent viral infection Proceedings of the National Academy of Sciences of the United States of America 2012 109:14116-14121 DOI:10.1073/pnas.1211910109 PMID:22893686 PMCID:PMC3435180
- Oldstone, M. B. A., Edelmann, K. H., McGavern, D. B., Cruite, J. T., Welch, M. J. Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes PLoS Pathogens 2012 8:e1003044 DOI:10.1371/journal.ppat.1003044 PMID:23209415 PMCID:PMC3510245
- Mahal, S. P., Jablonski, J., Suponitsky-Kroyter, I., Oelschlegel, A. M., Herva, M. E., Oldstone, M., Weissmann, C. Propagation of rml prions in mice expressing prp devoid of gpi anchor leads to formation of a novel, stable prion strain PLoS Pathogens 2012 8:e1002746 DOI:10.1371/journal.ppat.1002746 PMID:22685404 PMCID:PMC3369955
- Blasius, A. L., Krebs, P., Sullivan, B. M., Oldstone, M. B., Popkin, D. L. Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection PLoS Pathogens 2012 8:e1002915 DOI:10.1371/journal.ppat.1002915 PMID:23028315 PMCID:PMC3441671
- Walsh, K. B., Teijaro, J. R., Zuniga, E. I., Welch, M. J., Fremgen, D. M., Blackburn, S. D., von Tiehl, K. F., Wherry, E. J., Flavell, R. A., Oldstone, M. B. A. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection Cell Host & Microbe 2012 11:643-653 DOI:10.1016/j.chom.2012.04.016 PMID:22704624 PMCID:PMC3377981
- Hara, Y., Balci-Hayta, B., Yoshida-Moriguchi, T., Kanagawa, M., de Bernabe, D. B. V., Gundesli, H., Willer, T., Satz, J. S., Crawford, R. W., Burden, S. J., Kunz, S., Oldstone, M. B. A., et al. A dystroglycan mutation associated with limb-girdle muscular dystrophy New England Journal of Medicine 2011 364:939-946 DOI:10.1056/NEJMoa1006939 PMID:21388311 PMCID:PMC3071687
- Oldstone, M. B. A., Campbell, K. P. Decoding arenavirus pathogenesis: Essential roles for alpha-dystroglycan-virus interactions and the immune response Virology 2011 411:170-179 DOI:10.1016/j.virol.2010.11.023 PMID:21185048 PMCID:PMC3071849
- Krebs, P., Crozat, K., Popkin, D., Oldstone, M. B., Beutler, B. Disruption of myd88 signaling suppresses hemophagocytic lymphohistiocytosis in mice Blood 2011 117:6582-6588 DOI:10.1182/blood-2011-01-329607 PMID:21551232 PMCID:PMC3123024
- Teijaro, J. R., Walsh, K. B., Cahalan, S., Fremgen, D. M., Roberts, E., Scott, F., Martinborough, E., Peach, R., Oldstone, M. B. A., Rosen, H. Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Cell 2011 146:979-990 DOI:10.1016/j.cell.2011.08.015 PMID:21925319 PMCID:PMC3176439
- Popkin, D. L., Teijaro, J. R., Lee, A. M., Lewicki, H., Emonet, S., de la Torre, J. C., Oldstone, M. Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: Protein production, antibody production, and in vivo assessment of biological function of genes of interest Journal of Virology 2011 85:7928-7932 DOI:10.1128/jvi.00486-11 PMID:21613399 PMCID:PMC3147893
- Lee, A. M., Paulsson, J. F., Cruite, J., Andaya, A. A., Trifilo, M. J., Oldstone, M. B. A. Extraneural manifestations of prion infection in gpi-anchorless transgenic mice Virology 2011 411:1-8 DOI:10.1016/j.virol.2010.12.012 PMID:21227476 PMCID:PMC3039103
- Popkin, D. L., Teijaro, J. R., Sullivan, B. M., Urata, S., Rutschmann, S., de la Torre, J. C., Kunz, S., Beutler, B., Oldstone, M. Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner Cell Host & Microbe 2011 9:212-222 DOI:10.1016/j.chom.2011.02.006 PMID:21402360 PMCID:PMC3058147
- Hara, Y., Kanagawa, M., Kunz, S., Yoshida-Moriguchi, T., Satz, J. S., Kobayashi, Y. M., Zhu, Z. H., Burden, S. J., Oldstone, M. B. A., Campbell, K. P. Like-acetylglucosaminyltransferase (large)-dependent modification of dystroglycan at thr-317/319 is required for laminin binding and arenavirus infection Proceedings of the National Academy of Sciences of the United States of America 2011 108:17426-17431 DOI:10.1073/pnas.1114836108 PMID:21987822 PMCID:PMC3198351
- Sullivan, B. M., Emonet, S. F., Welch, M. J., Lee, A. M., Campbell, K. P., de la Torre, J. C., Oldstone, M. B. Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence Proceedings of the National Academy of Sciences of the United States of America 2011 108:2969-2974 DOI:10.1073/pnas.1019304108 PMID:21270335 PMCID:PMC3041138
- Walsh, K. B., Teijaro, J. R., Rosen, H., Oldstone, M. B. A. Quelling the storm: Utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm Immunologic Research 2011 51:15-25 DOI:10.1007/s12026-011-8240-z PMID:21901448
- Ward, S. V., George, C. X., Welch, M. J., Liou, L. Y., Hahm, B., Lewicki, H., de la Torre, J. C., Samuel, C. E., Oldstone, M. B. RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis Proceedings of the National Academy of Sciences of the United States of America 2011 108:331-336 DOI:10.1073/pnas.1017241108 PMID:21173229 PMCID:PMC3017198
- Walsh, K. B., Teijaro, J. R., Wilker, P. R., Jatzek, A., Fremgen, D. M., Das, S. C., Watanabe, T., Hatta, M., Shinya, K., Suresh, M., Kawaoka, Y., Rosen, H., et al. Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus Proceedings of the National Academy of Sciences of the United States of America 2011 108:12018-12023 DOI:10.1073/pnas.1107024108 PMID:21715659 PMCID:PMC3142000
- Ng, C. T., Sullivan, B. M., Oldstone, M. B. A. The role of dendritic cells in viral persistence Current Opinion in Virology 2011 1:160-166 DOI:10.1016/j.coviro.2011.05.006 PMID:21909344 PMCID:PMC3167161
- Liou, L. Y., Walsh, K. B., Vartanian, A. R., de Bernabe, D. B. V., Welch, M., Campbell, K. P., Oldstone, M. B. A., Kunz, S. Functional glycosylation of dystroglycan is crucial for thymocyte development in the mouse PLoS One 2010 5:e9915 DOI:10.1371/journal.pone.0009915 PMID:20369005 PMCID:PMC2848029
- Brooks, D. G., Walsh, K. B., Elsaesser, H., Oldstone, M. B. A. Il-10 directly suppresses cd4 but not cd8 t cell effector and memory responses following acute viral infection Proceedings of the National Academy of Sciences of the United States of America 2010 107:3018-3023 DOI:10.1073/pnas.0914500107 PMID:20133700 PMCID:PMC2840337
- Alter, G., Kavanagh, D., Rihn, S., Luteijn, R., Brooks, D., Oldstone, M., van Lunzen, J., Altfeld, M. Il-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of hiv infection Journal of Clinical Investigation 2010 120:1905-1913 DOI:10.1172/jci40913 PMID:20440075 PMCID:PMC2877944
- Yoshida-Moriguchi, T., Yu, L. P., Stalnaker, S. H., Davis, S., Kunz, S., Madson, M., Oldstone, M. B. A., Schachter, H., Wells, L., Campbell, K. P. O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding Science 2010 327:88-92 DOI:10.1126/science.1180512 PMID:20044576 PMCID:PMC2978000
- Walsh, K. B., Marsolais, D., Welch, M. J., Rosen, H., Oldstone, M. B. A. Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection Virology 2010 397:260-269 DOI:10.1016/j.virol.2009.08.043 PMID:19962171 PMCID:PMC2821988
- Marsolais, D., Hahm, B., Walsh, K. B., Edelmann, K. H., McGavern, D., Hatta, Y., Kawaoka, Y., Rosen, H., Oldstone, M. B. A. A critical role for the sphingosine analog aal-r in dampening the cytokine response during influenza virus infection Proceedings of the National Academy of Sciences of the United States of America 2009 106:1560-1565 DOI:10.1073/pnas.0812689106 PMID:19164548 PMCID:PMC2635800
- Horwitz, M. S., Efrat, S., Christen, U., von Herrath, M. G., Oldstone, M. B. A. Adenovirus e3 mhc inhibitory genes but not tnf/fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes Proceedings of the National Academy of Sciences of the United States of America 2009 106:19450-19454 DOI:10.1073/pnas.0910648106 PMID:19887639 PMCID:PMC2780797
- Oldstone, M. B. A. Anatomy of viral persistence PLoS Pathogens 2009 5:e1000523 DOI:10.1371/journal.ppat.1000523 PMID:19649277 PMCID:PMC2713431
- Han, R., Kanagawa, M., Yoshida-Moriguchi, T., Rader, E. P., Ng, R. A., Michele, D. E., Muirhead, D. E., Kunz, S., Moore, S. A., Iannaccone, S. T., Miyake, K., McNeil, P. L. Basal lamina strengthens cell membrane integrity via the laminin g domain-binding motif of alpha-dystroglycan Proceedings of the National Academy of Sciences of the United States of America 2009 106:12573-12579 DOI:10.1073/pnas.0906545106 PMID:19633189 PMCID:PMC2715328
- Whitby, L. R., Lee, A. M., Kunz, S., Oldstone, M. B. A., Boger, D. L. Characterization of lassa virus cell entry inhibitors: Determination of the active enantiomer by asymmetric synthesis Bioorganic & Medicinal Chemistry Letters 2009 19:3771-3774 DOI:10.1016/j.bmcl.2009.04.098 PMID:19428249 PMCID:PMC2742202
- Oldstone, M. B. A. Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control Current Topics in Microbiology and Immunology 2009 330:31-54 DOI:10.1007/978-3-540-70617-5_2 PMID:19203103
- Race, B., Meade-White, K., Oldstone, M. B. A., Race, R., Chesebro, B. Detection of prion infectivity in fat tissues of scrapie-infected mice PLoS Pathogens 2008 4:e1000232 DOI:10.1371/journal.ppat.1000232 PMID:19057664 PMCID:PMC2585054
- Brooks, D. G., Ha, S. J., Elsaesser, H., Sharpe, A. H., Freeman, G. J., Oldstone, M. B. A. IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection Proceedings of the National Academy of Sciences of the United States of America 2008 105:20428-20433 DOI:10.1073/pnas.0811139106 PMID:19075244 PMCID:PMC2629263
- Brooks, D. G., Lee, A. M., Elsaesser, H., McGavern, D. B., Oldstone, M. B. A. Il-10 blockade facilitates DNA vaccine-induced t cell responses and enhances clearance of persistent virus infection Journal of Experimental Medicine 2008 205:533-541 DOI:10.1084/jem.20071948 PMID:18332180 PMCID:PMC2275377
- Liou, L. Y., Blasius, A. L., Welch, M. J., Colonna, M., Oldstone, M. B. A., Zuniga, E. I. In vivo conversion of bm plasmacytoid dc into cd11b(+) conventional dc during virus infection European Journal of Immunology 2008 38:3388-3394 DOI:10.1002/eji.200838282 PMID:18979509 PMCID:PMC2897746
- Marsolais, D., Hahm, B., Edelmann, K. H., Walsh, K. B., Guerrero, M., Hatta, Y., Kawaoka, Y., Roberts, E., Oldstone, M. B. A., Rosen, H. Local not systemic modulation of dendritic cell s1p receptors in lung blunts virus-specific immune responses to influenza Molecular Pharmacology 2008 74:896-903 DOI:10.1124/mol.108.048769 PMID:18577684 PMCID:PMC2574812
- Zuniga, E. I., Liou, L. Y., Mack, L., Mendoza, M., Oldstone, M. B. A. Persistent virus infection inhibits type i interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections Cell Host & Microbe 2008 4:374-386 DOI:10.1016/j.chom.2008.08.016 PMID:18854241 PMCID:PMC2875928
- Trifilo, M. J., Sanchez-Alavez, M., Solforosi, L., Bernard-Trifilo, J., Kunz, S., McGavern, D., Oldstone, M. B. A. Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway Journal of Virology 2008 82:9890-9899 DOI:10.1128/jvi.00486-08 PMID:18667494 PMCID:PMC2566293
- Lee, A. M., Rojek, J. M., Spiropoulou, C. F., Gundersen, A. T., Jin, W., Shaginian, A., York, J., Nunberg, J. H., Boger, D. L., Oldstone, M. B. A., Kunz, S. Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses Journal of Biological Chemistry 2008 283:18734-18742 DOI:10.1074/jbc.M802089200 PMID:18474596 PMCID:PMC2441566
- Oldstone, M. B. A. A suspenseful game of 'hide and seek' between virus and host Nature Immunology 2007 8:325-327 DOI:10.1038/ni0407-325 PMID:17375090
- Trifilo, M. J., Ying, G., Teng, C., Oldstone, M. B. A. Chronic wasting disease of deer and elk in transgenic mice: Oral transmission and pathobiology Virology 2007 365:136-143 DOI:10.1016/j.virol.2007.03.032 PMID:17451773 PMCID:PMC1950321
- Homann, D., Lewicki, H., Brooks, D., Eberlein, J., Mallet-Designe, V., Teyton, L., Oldstone, M. B. A. Mapping and restriction of a dominant viral CD4(+) T cell core epitope by both MHC class I and MHC class II Virology 2007 363:113-123 DOI:10.1016/j.virol.2006.12.025 PMID:17320138 PMCID:PMC1976554
- Hahm, B., Cho, J. H., Oldstone, M. B. A. Measles virus-dendritic cell interaction via slam inhibits innate immunity: Selective signaling through tlr4 but not other tlrs mediates suppression of il-12 synthesis Virology 2007 358:251-257 DOI:10.1016/j.virol.2006.10.04 PMID:17070884
- Rojek, J. M., Campbell, K. P., Oldstone, M. B. A., Kunz, S. Old world arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell Molecular Biology of the Cell 2007 18:4493-4507 DOI:10.1091/mbc.E07-04-0374 PMID:17761532 PMCID:PMC2043543
- Ahmed, R., Oldstone, M. B. A., Palese, P. Protective immunity and susceptibility to infectious diseases: Lessons from the 1918 influenza pandemic Nature Immunology 2007 8:1188-1193 DOI:10.1038/ni1530 PMID:17952044
- Meade-White, K., Race, B., Trifilo, M., Bossers, A., Favara, C., Lacasse, R., Miller, M., Williams, E., Oldstone, M., Race, R., Chesebro, B. Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein Journal of Virology 2007 81:4533-4539 DOI:10.1128/jvi.02762-06 PMID:17314157
- Rothlin, C. V., Ghosh, S., Zuniga, E. I., Oldstone, M. B. A., Lemke, G. Tam receptors are pleiotropic inhibitors of the innate immune response Cell 2007 131:1124-1136 DOI:10.1016/j.cell.2007.10.034 PMID:18083102
- Zuniga, E. I., Hahm, B., Oldstone, M. B. A. Type i interferon during viral infections: Multiple triggers for a multifunctional mediator Current Topics in Microbiology and Immunology 2007 316:337-357 PMID:17969455
- Oldstone, M. B. A. Vaccine: the controversial story of medicine's greatest lifesaver Nature 2007 448:137 DOI:10.1038/448137a
- Georgel, P., Jiang, Z. F., Kunz, S., Janssen, E., Mols, J., Hoebe, K., Bahram, S., Oldstone, M. B. A., Beutler, B. Vesicular stomatitis virus glycoprotein g activates a specific antiviral toll-like receptor 4-dependent pathway Virology 2007 362:304-313 DOI:10.1016/j.virol.2006.12.032 PMID:17292937
- Lauterbach, H., Zuniga, E. I., Truong, P., Oldstone, M. B. A., McGavern, D. B. Adoptive immunotherapy induces cns dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection Journal of Experimental Medicine 2006 203:1963-1975 DOI:10.1084/jem.20060039 PMID:16847068 PMCID:PMC2118382
- Kunz, S., Rojek, J. M., Roberts, A. J., McGavern, D. B., Oldstone, M. B. A., de la Torre, J. C. Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus Journal of Virology 2006 80:9082-9092 DOI:10.1128/jvi.00795-06 PMID:16940520
- Tishon, A., Lewicki, H., Andaya, A., McGavern, D., Martin, L., Oldstone, M. B. A. Cd4 t cell control primary measles virus infection of the cns: Regulation is dependent on combined activity with either cd8 t cells or with b cells: Cd4, cd8 or b cells alone are ineffective Virology 2006 347:234-245 DOI:10.1016/j.virol.2006.01.050 PMID:16529787
- Trifilo, M. J., Hahm, B., Zuniga, E. I., Edelmann, K. H., Oldstone, M. B. A. Dendritic cell inhibition: Memoirs from immunosuppressive viruses Journal of Infectious Diseases 2006 194:S3-S10 DOI:10.1086/505355 PMID:16921469
- Brooks, D. G., Trifilo, M. J., Edelmann, K. H., Teyton, L., McGavern, D. B., Oldstone, M. B. A. Interleukin-10 determines viral clearance or persistence in vivo Nature Medicine 2006 12:1301-1309 DOI:10.1038/nm1492 PMID:17041596 PMCID:PMC2535582
- Homann, D., Dummer, W., Wolfe, T., Rodrigo, E., Theofilopoulos, A. N., Oldstone, M. B. A., von Herrath, M. G. Lack of intrinsic ctla-4 expression has minimal effect on regulation of antiviral t-cell immunity Journal of Virology 2006 80:270-280 DOI:10.1128/jvi.80.1.270-280.2006 PMID:16352552
- Go, E. P., Wikoff, W. R., Shen, Z. X., O'Maille, G., Morita, H., Conrads, T. P., Nordstrom, A., Trauger, S. A., Uritboonthai, W., Lucas, D. A., Chan, K. C., Veenstra, T. D., et al. Mass spectrometry reveals specific and global molecular transformations during viral infection Journal of Proteome Research 2006 5:2405-2416 DOI:10.1021/pr060215t PMID:16944953 PMCID:PMC2566936
- Trifilo, M. J., Yajima, T., Gu, Y. S., Dalton, N., Peterson, K. L., Race, R. E., Meade-White, K., Portis, J. L., Masliah, E., Knowlton, K. U., Chesebro, B., Oldstone, M. B. A. Prion-induced amyloid heart disease with high blood infectivity in transgenic mice Science 2006 313:94-97 DOI:10.1126/science.1128635 PMID:16825571 PMCID:PMC1820586
- Brooks, D. G., McGavern, D. B., Oldstone, M. B. A. Reprogramming of antiviral t cells prevents inactivation and restores t cell activity during persistent viral infection Journal of Clinical Investigation 2006 116:1675-1685 DOI:10.1172/jci26856 PMID:16710479
- Oldstone, M. B. A. Viral persistence: Parameters, mechanisms and future predictions Virology 2006 344:111-118 DOI:10.1016/j.virol.2005.09.028 PMID:16364742
- Oldstone, M. B. A., Dales, S., Tishon, A., Lewicki, H., Martin, L. A role for dual viral hits in causation of subacute sclerosing panencephalitis Journal of Experimental Medicine 2005 202:1185-1190 DOI:10.1084/jem.20051376 PMID:16260490 PMCID:PMC1350947
- Chesebro, B., Trifilo, M., Race, R., Meade-White, K., Teng, C., LaCasse, R., Raymond, L., Favara, C., Baron, G., Priola, S., Caughey, B., Masliah, E., et al. Anchorless prion protein results in infectious amyloid disease without clinical scrapie Science 2005 308:1435-1439 DOI:10.1126/science.1110837 PMID:15933194
- Oldstone, M. B. A. Book review: Spores, plagues, and history: the story of anthrax Bulletin of the History of Medicine 2005 79:381-383 DOI:10.1353/bhm.2005.0083
- Kunz, S., Rojek, J. M., Perez, M., Spiropoulou, C. F., Oldstone, M. B. A. Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan Journal of Virology 2005 79:5979-5987 DOI:10.1128/jvi.79.10.5979-5987.2005 PMID:15857984
- Zuniga, E. I., Hahm, B., Edelmann, K. H., Oldstone, M. B. A. Immunosuppressive viruses and dendritic cells: a multifront war ASM News 2005 71:285-290
- Brooks, D. G., Teyton, L., Oldstone, M. B. A., McGavern, D. B. Intrinsic functional dysregulation of CD4 T cells occurs rapidly following persistent viral infection Journal of Virology 2005 79:10514-10527 DOI:10.1128/jvi.79.16.10514-10527.2005 PMID:16051844 PMCID:PMC1182641
- Rhode, A., Pauza, M. E., Barral, A. M., Rodrigo, E., Oldstone, M. B. A., von Herrath, M. G., Christen, U. Islet-specific expression of cxcl10 causes spontaneous islet infiltration and accelerates diabetes development Journal of Immunology 2005 175:3516-3524 PMID:16148094
- Criado, J. R., Sanchez-Alavez, M., Conti, B., Giacchino, J. L., Wills, D. N., Henriksen, S. J., Race, R., Manson, J. C., Chesebro, B., Oldstone, M. B. A. Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons Neurobiology of Disease 2005 19:255-265 DOI:10.1016/j.nbd.2004.01.001 PMID:15837581
- Oldstone, M. B. A. Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry Current Topics in Microbiology and Immunology 2005 296:65-87 PMID:16329191
- Oldstone, M. B. A. Molecular mimicry, microbial infection, and autoimmune disease: evolution of the concept Current Topics in Microbiology and Immunology 2005 296:1-17 PMID:16329189
- Kunz, S., Rojek, J. M., Kanagawa, M., Spiroroulou, C. F., Barresi, R., Campbell, K. P., Oldstone, M. B. A. Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase large is critical for virus binding Journal of Virology 2005 79:14282-14296 DOI:10.1128/jvi.79.22.14282-14296.2005 PMID:16254363
- Hahm, B., Trifilo, M. J., Zuniga, E. I., Oldstone, M. B. A. Viruses evade the immune system through type i interferon-mediated stat2-dependent, but stat1-independent, signaling Immunity 2005 22:247-257 DOI:10.1016/j.immuni.2005.01.005 PMID:15723812
- Christen, U., Edelmann, K. H., McGavern, D. B., Wolfe, T., Coon, B., Teague, M. K., Miler, S. D., Oldstone, M. B. A., von Herrath, M. G. A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes Journal of Clinical Investigation 2004 114:1290-1298 DOI:10.1172/jci200422557 PMID:15520861
- Zuniga, E. I., McGavern, D. B., Pruneda-Paz, J. L., Teng, C., Oldstone, M. B. A. Bone marrow plasmacytoid dendritic cells can differentiate into myeloid dendritic cells upon virus infection Nature Immunology 2004 5:1227-1234 DOI:10.1038/ni1136 PMID:15531885
- Solforosi, L., Criado, J. R., McGavern, D. B., Wirz, S., Sanchez-Alavez, M., Sugama, S., DeGiorgio, L. A., Volpe, B. T., Wiseman, E., Abalos, G., Masliah, E., Gilden, D., et al. Cross-linking cellular prion protein triggers neuronal apoptosis in vivo Science 2004 303:1514-1516 DOI:10.1126/science.1094273 PMID:14752167
- Christen, U., Benke, D., Wolfe, T., Rodrigo, E., Rhode, A., Hughes, A. C., Oldstone, M. B. A., von Herrath, M. G. Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient Journal of Clinical Investigation 2004 113:74-84 DOI:10.1172/jci200417005 PMID:14702111 PMCID:PMC300760
- Naniche, D., Garenne, M., Rae, C., Manchester, M., Buchta, R., Brodine, S. K., Oldstone, M. B. A. Decrease in measles virus-specific cd4 t cell memory in vaccinated subjects Journal of Infectious Diseases 2004 190:1387-1395 DOI:10.1086/424571 PMID:15378430
- Edelmann, K. H., Richardson-Burns, S., Alexopoulou, L., Tyler, K. L., Flavell, R. A., Oldstone, M. B. A. Does toll-like receptor 3 play a biological role in virus infections? Virology 2004 322:231-238 DOI:10.1016/j.virol.2004.01.033 PMID:15110521
- Kunz, S., Calder, L., Oldstone, M. B. A. Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virus Virology 2004 325:207-215 DOI:10.1016/j.virol.2004.04.044 PMID:15246261
- Oldstone, M. B. A. Future trends in neurovirology: Neuronal survival during virus infection and analysis of virus-specific t cells in central nervous system tissues Journal of Neurovirology 2004 10:207-215 DOI:10.1080/13550280490468438 PMID:15371150
- Lenz, D. C., Kurz, S. K., Lemmens, E., Schoenberger, S. P., Sprent, J., Oldstone, M. B. A., Homann, D. Il-7 regulates basal homeostatic proliferation of antiviral cd4(+)t cell memory Proceedings of the National Academy of Sciences of the United States of America 2004 101:9357-9362 DOI:10.1073/pnas.0400640101 PMID:15197277 PMCID:PMC438981
- Oldstone, M. B. A. MMR and autism: what parents need to know Nature 2004 432:275-276 DOI:10.1038/432275a
- Oldstone, M. B. A. MMR science & fiction: exploring a vaccine crisis Nature 2004 432:275-276 DOI:10.1038/432275a
- Hahm, B., Arbour, N., Oldstone, M. B. A. Measles virus interacts with human slam receptor on dendritic cells to cause immuno suppression Virology 2004 323:292-302 DOI:10.1016/j.virol.2004.03.011 PMID:15193925 PMCID:PMC5050034
- Kanagawa, M., Saito, F., Kunz, S., Yoshida-Moriguchi, T., Barresi, R., Kobayashi, Y. M., Muschler, J., Dumanski, J. P., Michele, D. E., Oldstone, M. B. A., Campbell, K. P. Molecular recognition by large is essential for expression of functional dystroglycan Cell 2004 117:953-964 DOI:10.1016/j.cell.2004.06.003 PMID:15210115
- Kunz, S., Sevilla, N., Rojek, J. M., Oldstone, M. B. A. Use of alternative receptors different than alpha-dystroglycan by selected isolates of lymphocytic choriomeningitis virus Virology 2004 325:432-445 DOI:10.1016/j.virol.2004.05.009 PMID:15246281
- Sevilla, N., McGavern, D. B., Teng, C., Kunz, S., Oldstone, M. B. A. Viral targeting of hematopoietic progenitors and inhibition of dc maturation as a dual strategy for immune subversion Journal of Clinical Investigation 2004 113:737-745 DOI:10.1172/jci20243 PMID:14991072
- Homann, D., McGavern, D. B., Oldstone, M. B. A. Visualizing the viral burden: Phenotypic and functional alterations of t cells and apcs during persistent infection Journal of Immunology 2004 172:6239-6250 PMID:15128812
- Arbour, N., Holz, A., Sipe, J. C., Naniche, D., Romine, J. S., Zyroff, J., Oldstone, M. B. A. A new approach for evaluating antigen-specific t cell responses to myelin antigens during the course of multiple sclerosis Journal of Neuroimmunology 2003 137:197-209 DOI:10.1016/s0165-5728(03)00080-8 PMID:12667664
- Kunz, S., Campbell, K. P., Oldstone, M. B. A. Alpha-dystroglycan can mediate arenavirus infection in the absence of beta-dystroglycan Virology 2003 316:213-220 DOI:10.1016/s0042-6822(03)00592-0 PMID:14644604
- Christen, U., McGavern, D. B., Luster, A. D., von Herrath, M. G., Oldstone, M. B. A. Among cxcr3 chemokines, ifn-gamma-inducible protein of 10 kda (cxc chemokine ligand (cxcl) 10) but not monokine induced by ifn-gamma (cxcl9) imprints a pattern for the subsequent development of autoimmune disease Journal of Immunology 2003 171:6838-6845 PMID:14662890
- Mallet-Designe, V. I., Stratmann, T., Homann, D., Carbone, F., Oldstone, M. B. A., Teyton, L. Detection of low-avidity CD4(+) T cells using recombinant artificial APC: following the antiovalbumin immune response Journal of Immunology 2003 170:123-131 PMID:12496391
- Sevilla, N., Kunz, S., McGavern, D., Oldstone, M. B. A. Infection of dendritic cells by lymphocytic choriomeningitis virus Current Topics in Microbiology and Immunology 2003 276:125-144 PMID:12797446
- Slifka, M. K., Homann, D., Tishon, A., Pagarigan, R., Oldstone, M. B. A. Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection Journal of Clinical Investigation 2003 111:805-810 DOI:10.1172/jci200313603 PMID:12639986
- Hahm, B., Arbour, N., Naniche, D., Homann, D., Manchester, M., Oldstone, M. B. A. Measles virus infects and suppresses proliferation of t lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule Journal of Virology 2003 77:3505-3515 DOI:10.1128/jvi.77.6.3505-3515.2003 PMID:12610126
- Kunz, S., Edelmann, K. H., de la Torre, J. C., Gorney, R., Oldstone, M. B. A. Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions Virology 2003 314:168-178 DOI:10.1016/s0042-6822(03)00421-5 PMID:14517070
- Slifka, M. K., Blattman, J. N., Sourdive, D. J. D., Liu, F., Huffman, D. L., Wolfe, T., Hughes, A., Oldstone, M. B. A., Ahmed, R., von Herrath, M. G. Preferential escape of subdominant cd8(+) t cells during negative selection results in an altered antiviral t cell hierarchy Journal of Immunology 2003 170:1231-1239 PMID:12538681
- Stratmann, T., Martin-Orozco, N., Mallet-Designe, V., Poirot, L., McGavern, D., Losyev, G., Dobbs, C. M., Oldstone, M. B. A., Yoshida, K., Kikutani, H., Mathis, D., Benoist, C., et al. Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity Journal of Clinical Investigation 2003 112:902-914 DOI:10.1172/jci200318337 PMID:12975475 PMCID:PMC193666
- Lewicki, H., Tishon, A., Homann, D., Mazarguil, H., Laval, F., Asensio, V. C., Campbell, I. L., DeArmond, S., Coon, B., Teng, C., Gairin, J. E., Oldstone, M. B. A. T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies Journal of Virology 2003 77:3799-3808 DOI:10.1128/jvi.77.6.3799-3808.2003 PMID:12610154
- Rambukkana, A., Kunz, S., Min, J., Campbell, K. P., Oldstone, M. B. A. Targeting schwann cells by nonlytic arenaviral infection selectively inhibits myelination Proceedings of the National Academy of Sciences of the United States of America 2003 100:16071-16076 DOI:10.1073/pnas.2232366100 PMID:14657400 PMCID:PMC307694
- Oldstone, M. B. A. Arenaviruses i - the epidemiology, molecular and cell biology of arenaviruses - preface Arenaviruses I 2002 262:V-XII PMID:11987810
- Oldstone, M. B. A. Biology and pathogenesis of lymphocytic choriomeningitis virus infection Arenaviruses II 2002 263:83-117 PMID:11987822
- Oldstone, M. B. A., Race, R., Thomas, D., Lewicki, H., Homann, D., Smelt, S., Holz, A., Koni, P., Lo, D., Chesebro, B., Flavell, R. Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: Evidence against dendritic cell involvement in neuroinvasion Journal of Virology 2002 76:4357-4363 DOI:10.1128/jvi.76.9.4357-4363.2002 PMID:11932402
- McGavern, D. B., Christen, U., Oldstone, M. B. A. Molecular anatomy of antigen-specific cd8(+) t cell engagement and synapse formation in vivo Nature Immunology 2002 3:918-925 DOI:10.1038/ni843 PMID:12352968 PMCID:PMC2481514
- Spiropoulou, C. F., Kunz, S., Rollin, P. E., Campbell, K. P., Oldstone, M. B. A. New world arenavirus clade c, but not clade a and b viruses, utilizes alpha-dystroglycan as its major receptor Journal of Virology 2002 76:5140-5146 DOI:10.1128/jvi.76.10.5140-5146.2002 PMID:11967329
- Oldstone, M. B. A., Homann, D., Lewicki, H., Stevenson, D. One, two, or three step: Measles virus receptor dance Virology 2002 299:162-163 DOI:10.1006/viro.2002.1507 PMID:12202218
- Kunz, S., Borrow, P., Oldstone, M. B. A. Receptor structure, binding, and cell entry of arenaviruses Arenaviruses I 2002 262:111-137 PMID:11987803
- McGavern, D. B., Homann, D., Oldstone, M. B. A. T cells in the central nervous system: The delicate balance between viral clearance and disease Journal of Infectious Diseases 2002 186:S145-S151 DOI:10.1086/344264 PMID:12424690
- Oldstone, M. B. A. Travels along the viral-immunobiology highway Immunological Reviews 2002 185:54-68 DOI:10.1034/j.1600-065X.2002.18507.x PMID:12190922
- Arbour, N., Naniche, D., Homann, D., Davis, R. J., Flavell, R. A., Oldstone, M. B. A. c-Jun NH2-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity Journal of Experimental Medicine 2002 195:801-810 DOI:10.1084/jem.20011481 PMID:11927625 PMCID:PMC2193720
- Oldstone, M. B. A., Lewicki, H., Homann, D., Nguyen, C., Julien, S., Gairin, J. E. Common antiviral cytotoxic t-lymphocyte epitope for diverse arenaviruses Journal of Virology 2001 75:6273-6278 DOI:10.1128/jvi.75.14.6273-6278.2001 PMID:11413293
- Holz, A., Brett, K., Oldstone, M. B. A. Constitutive beta cell expression of il-12 does not perturb self-tolerance but intensifies established autoimmune diabetes Journal of Clinical Investigation 2001 108:1749-1758 DOI:10.1172/jci200113915 PMID:11748258
- Smelt, S. C., Borrow, P., Kunz, S., Cao, W., Tishon, A., Lewicki, H., Campbell, K. P., Oldstone, M. B. A. Differences in affinity of binding of lymphocytic choriomeningitis virus strains to the cellular receptor alpha-dystroglycan correlate with viral tropism and disease kinetics Journal of Virology 2001 75:448-457 DOI:10.1128/jvi.75.1.448-457.2001 PMID:11119613
- Homann, D., Teyton, L., Oldstone, M. B. A. Differential regulation of antiviral T-cell immunity results in stable CD8(+) but declining CD4(+) T-cell memory Nature Medicine 2001 7:913-919 DOI:10.1038/90950 PMID:11479623
- Patterson, J. B., Manchester, M., Oldstone, M. B. A. Disease model: Dissecting the pathogenesis of the measles virus Trends in Molecular Medicine 2001 7:85-88 DOI:10.1016/s1471-4914(01)01918-9 PMID:11286761
- Bureau, J. F., Le Goff, S., Thomas, D., Parlow, A. F., de la Torre, J. C., Homann, D., Brahic, M., Oldstone, M. B. A. Disruption of differentiated functions during viral infection in vivo - v. Mapping of a locus involved in susceptibility of mice to growth hormone deficiency due to persistent lymphocytic choriomeningitis virus infection Virology 2001 281:61-66 DOI:10.1006/viro.2000.0800 PMID:11222096
- Patterson, J. B., Cornu, T. I., Redwine, J., Dales, S., Lewicki, H., Holz, A., Thomas, D., Billeter, M. A., Oldstone, M. B. A. Evidence that the hypermutated m protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive cns disease Virology 2001 291:215-225 DOI:10.1006/viro.2001.1182 PMID:11878891
- Kunz, S., Sevilla, N., McGavern, D. B., Campbell, K. P., Oldstone, M. B. A. Molecular analysis of the interaction of lcmv with its cellular receptor alpha-dystroglycan Journal of Cell Biology 2001 155:301-310 DOI:10.1083/jcb.200104103 PMID:11604425 PMCID:PMC2198839
- Hudrisier, D., Riond, J., Burlet-Schiltz, O., von Herrath, M. G., Lewicki, H., Monsarrat, B., Oldstone, M. B. A., Gairin, J. E. Structural and functional identification of major histocompatibility complex class i-restricted self-peptides as naturally occurring molecular mimics of viral antigens - possible role in cd8(+) t cell-mediated, virus-induced autoimmune disease Journal of Biological Chemistry 2001 276:19396-19403 DOI:10.1074/jbc.M008864200 PMID:11278441
- Manchester, M., Eto, D. S., Valsamakis, A., Liton, P. B., Fernandez-Munoz, R., Rota, P. A., Bellini, W. J., Forthal, D. N., Oldstone, M. B. A. Clinical isolates of measles virus use cd46 as a cellular receptor? Journal of Virology 2000 74:3967-3974 DOI:10.1128/jvi.74.9.3967-3974.2000 PMID:10756008
- Berger, D. P., Homann, D., Oldstone, M. B. A. Defining parameters for successful immunocytotherapy of persistent viral infection Virology 2000 266:257-263 DOI:10.1006/viro.1999.0074 PMID:10639312
- Race, R., Oldstone, M., Chesebro, B. Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: Role of prion protein expression in peripheral nerves and spleen Journal of Virology 2000 74:828-833 DOI:10.1128/jvi.74.2.828-833.2000 PMID:10623745
- Naniche, D., Yeh, A., Eto, D., Manchester, M., Friedman, R. M., Oldstone, M. B. A. Evasion of host defenses by measles virus: Wild-type measles virus infection interferes with induction of alpha/beta interferon production Journal of Virology 2000 74:7478-7484 DOI:10.1128/jvi.74.16.7478-7484.2000 PMID:10906201
- Naniche, D., Oldstone, M. B. A. Generalized immunosuppression: How viruses undermine the immune response Cellular and Molecular Life Sciences 2000 57:1399-1407 DOI:10.1007/pl00000625 PMID:11078019
- Sevilla, N., Kunz, S., Holz, A., Lewicki, H., Homann, D., Yamada, H., Campbell, K. P., de la Torre, J. C., Oldstone, M. B. A. Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells Journal of Experimental Medicine 2000 192:1249-1260 DOI:10.1084/jem.192.9.1249 PMID:11067874
- Holz, A., Bielekova, B., Martin, R., Oldstone, M. B. A. Myelin-associated oligodendrocytic basic protein: Identification of an encephalitogenic epitope and association with multiple sclerosis Journal of Immunology 2000 164:1103-1109 PMID:10623862
- Lee, K. J., Novella, I. S., Teng, M. N., Oldstone, M. B. A., de la Torre, J. C. NP and l proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs Journal of Virology 2000 74:3470-3477 DOI:10.1128/jvi.74.8.3470-3477.2000 PMID:10729120
- Holz, A., Dyrberg, T., Hagopian, W., Homann, D., von Herrath, M., Oldstone, M. B. A. Neither b lymphocytes nor antibodies directed against self antigens of the islets of langerhans are required for development of virus-induced autoimmune diabetes Journal of Immunology 2000 165:5945-5953 PMID:11067957
- Tishon, A., LaFace, D. M., Lewicki, H., van Binnendijk, R. S., Osterhaus, A., Oldstone, M. B. A. Transgenic mice expressing human hla and cd8 molecules generate hla-restricted measles virus cytotoxic t lymphocytes of the same specificity as humans with natural measles virus infection Virology 2000 275:286-293 DOI:10.1006/viro.2000.0517 PMID:10998329
- Patterson, J. B., Thomas, D., Lewicki, H., Billeter, M. A., Oldstone, M. B. A. V and c proteins of measles virus function as virulence factors in vivo Virology 2000 267:80-89 DOI:10.1006/viro.1999.0118 PMID:10648185
- von Herrath, M. G., Berger, D. P., Homann, D., Tishon, T., Sette, A., Oldstone, M. B. A. Vaccination to treat persistent viral infection Virology 2000 268:411-419 DOI:10.1006/viro.1999.0130 PMID:10704349
- Oldstone, M. B. A., Levine, A. J. Virology in the next millennium Cell 2000 100:139-142 DOI:10.1016/s0092-8674(00)81690-6 PMID:10647938
- Sevilla, N., Homann, D., von Herrath, M., Rodriguez, F., Harkins, S., Whitton, J. L., Oldstone, M. B. A. Virus-induced diabetes in a transgenic model: Role of cross-reacting viruses and quantitation of effector t cells needed to cause disease Journal of Virology 2000 74:3284-3292 DOI:10.1128/jvi.74.7.3284-3292.2000 PMID:10708445
- Naniche, D., Reed, S. I., Oldstone, M. B. A. Cell cycle arrest during measles virus infection: A g(0)-like block leads to suppression of retinoblastoma protein expression Journal of Virology 1999 73:1894-1901 PMID:9971768 PMCID:PMC104430
- Eto, D. S., Oldstone, M. B. A., Manchester, M. Characterization of the inflammatory response during acute measles encephalitis in nse-cd46 transgenic mice Journal of Neuroimmunology 1999 96:207-217 DOI:10.1016/s0165-5728(99)00036-3 PMID:10337919
- Horwitz, M. S., Evans, C. F., Klier, F. G., Oldstone, M. B. A. Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the central nervous system: Astrocytes fail to express major histocompatibility complex class i and ii molecules Laboratory Investigation 1999 79:235-242 PMID:10068211
- Hudrisier, D., Riond, J., Mazarguil, H., Oldstone, M. B. A., Gairin, J. E. Genetically encoded and post-translationally modified forms of a major histocompatibility complex class i-restricted antigen bearing a glycosylation motif are independently processed and co-presented to cytotoxic t lymphocytes Journal of Biological Chemistry 1999 274:36274-36280 DOI:10.1074/jbc.274.51.36274 PMID:10593916
- Homann, D., Dyrberg, T., Petersen, J., Oldstone, M. B. A., von Herrath, M. G. Insulin in oral immune "tolerance": A one-amino acid change in the b chain makes the difference Journal of Immunology 1999 163:1833-1838 PMID:10438916
- Berger, D. P., Naniche, D., Crowley, M. T., Koni, P. A., Flavell, R. A., Oldstone, M. B. A. Lymphotoxin-beta-deficient mice show defective antiviral immunity Virology 1999 260:136-147 DOI:10.1006/viro.1999.9811 PMID:10405365
- Oldstone, M. B. A., Lewicki, H., Thomas, D., Tishon, A., Dales, S., Patterson, J., Manchester, M., Homann, D., Naniche, D., Holz, A. Measles virus infection in a transgenic model: Virus-induced immunosuppression and central nervous system disease Cell 1999 98:629-640 DOI:10.1016/s0092-8674(00)80050-1 PMID:10490102
- Puglielli, M. T., Browning, J. L., Brewer, A. W., Schreiber, R. D., Shieh, W. J., Altman, J. D., Oldstone, M. B. A., Zaki, S. R., Ahmed, R. Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway Nature Medicine 1999 5:1370-1374 PMID:10581078
- Patterson, J. B., Scheiflinger, F., Manchester, M., Yilma, T., Oldstone, M. B. A. Structural and functional studies of the measles virus hemagglutinin: Identification of a novel site required for cd46 interaction Virology 1999 256:142-151 DOI:10.1006/viro.1999.9644 PMID:10087234
- Oldstone, M. B. A., von Herrath, M., Lewicki, H., Hudrisier, D., Whitton, J. L., Gairin, J. E. Use of a high-affinity peptide that aborts mhc-restricted cytotoxic t lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo Virology 1999 256:246-257 DOI:10.1006/viro.1998.9593 PMID:10191190
- Borrow, P., Tough, D. F., Eto, D., Tishon, A., Grewal, I. S., Sprent, J., Flavell, R. A., Oldstone, M. B. A. Cd40 ligand-mediated interactions are involved in the generation of memory cd8(+) cytotoxic t lymphocytes (ctl) but are not required for the maintenance of ctl memory following virus infection Journal of Virology 1998 72:7440-7449 PMID:9696840
- Homann, D., Tishon, A., Berger, D. P., Weigle, W. O., von Herrath, M. G., Oldstone, M. B. A. Evidence for an underlying cd4 helper and cd8 t-cell defect in b-cell-deficient mice: Failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from mu mt/mu mt mice Journal of Virology 1998 72:9208-9216 PMID:9765468 PMCID:PMC110340
- Cao, W., Henry, M. D., Borrow, P., Yamada, H., Elder, J. H., Ravkov, E. V., Nichol, S. T., Compans, R. W., Campbell, K. P., Oldstone, M. B. A. Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and lassa fever virus Science 1998 282:2079-2081 DOI:10.1126/science.282.5396.2079 PMID:9851928
- von Herrath, M. G., Coon, B., Lewicki, H., Mazarguil, H., Gairin, J. E., Oldstone, M. B. A. In vivo treatment with a mhc class i-restricted blocking peptide can prevent virus-induced autoimmune diabetes Journal of Immunology 1998 161:5087-5096 PMID:9794447
- Oldstone, M. B. A. Molecular mimicry and immune-mediated diseases FASEB Journal 1998 12:1255-1265 PMID:9761770
- von Herrath, M. G., Holz, A., Homann, D., Oldstone, M. B. A. Role of viruses in type i diabetes Seminars in Immunology 1998 10:87-100 DOI:10.1006/smim.1997.0108 PMID:9529659
- Oldstone, M. B. Viral persistence: Mechanisms and consequences Current Opinion in Microbiology 1998 1:436-441 DOI:10.1016/s1369-5274(98)80062-3 PMID:10066504
- Rall, G. F., Manchester, M., Daniels, L. R., Callahan, E. M., Belman, A. R., Oldstone, M. B. A. A transgenic mouse model for measles virus infection of the brain Proceedings of the National Academy of Sciences of the United States of America 1997 94:4659-4663 DOI:10.1073/pnas.94.9.4659 PMID:9114047
- Borrow, P., Lewicki, H., Wei, X. P., Horwitz, M. S., Peffer, N., Meyers, H., Nelson, J. A., Gairin, J. E., Hahn, B. H., Oldstone, M. B. A., Shaw, G. M. Antiviral pressure exerted by hiv-1-specific cytotoxic t lymphocytes (ctls) during primary infection demonstrated by rapid selection of ctl escape virus Nature Medicine 1997 3:205-211 DOI:10.1038/nm0297-205 PMID:9018240
- Raeber, A. J., Race, R. E., Brandner, S., Priola, S. A., Sailer, A., Bessen, R. A., Mucke, L., Manson, J., Aguzzi, A., Oldstone, M. B. A., Weissmann, C., Chesebro, B. Astrocyte-specific expression of hamster prion protein (prp) renders prp knockout mice susceptible to hamster scrapie EMBO Journal 1997 16:6057-6065 DOI:10.1093/emboj/16.20.6057 PMID:9321385 PMCID:PMC1326289
- Brot, M. D., Rall, G. F., Oldstone, M. B. A., Koob, G. F., Gold, L. H. Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice Journal of Neurovirology 1997 3:265-273 PMID:9291234
- VonHerrath, M. G., Efrat, S., Oldstone, M. B. A., Horwitz, M. S. Expression of adenoviral e3 transgenes in beta cells prevents autoimmune diabetes Proceedings of the National Academy of Sciences of the United States of America 1997 94:9808-9813 DOI:10.1073/pnas.94.18.9808 PMID:9275207
- Oldstone, M. B. A. How viruses escape from cytotoxic t lymphocytes: Molecular parameters and players Virology 1997 234:179-185 DOI:10.1006/viro.1997.8674 PMID:9268148
- von Herrath, M. G., Oldstone, M. B. A. Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus Journal of Experimental Medicine 1997 185:531-539 DOI:10.1084/jem.185.3.531 PMID:9053453
- VonHerrath, M. G., Coon, B., Oldstone, M. B. A. Low-affinity cytotoxic t-lymphocytes require ifn-gamma to clear an acute viral infection Virology 1997 229:349-359 DOI:10.1006/viro.1997.8442 PMID:9126248
- Manchester, M., Gairin, J. E., Patterson, J. E., Alvarez, J., Liszewski, M. K., Eto, D. S., Atkinson, J. P., Oldstone, M. B. A. Measles virus recognizes its receptor, cd46, via two distinct binding domains within scr1-2 Virology 1997 233:174-184 DOI:10.1006/viro.1997.8581 PMID:9201227
- von Herrath, M. G., Homann, D., Gairin, J. E., Oldstone, M. B. A. Pathogenesis and treatment of virus-induced autoimmune diabetes: novel insights gained from the RIP-LCMV transgenic mouse model Biochemical Society Transactions 1997 25:630-635 PMID:9191170
- Horwitz, M. S., Evans, C. F., McGavern, D. B., Rodriguez, M., Oldstone, M. B. A. Primary demyelination in transgenic mice expressing interferon-gamma Nature Medicine 1997 3:1037-1041 DOI:10.1038/nm0997-1037 PMID:9288735
- Grewal, I. S., Borrow, P., Pamer, E. G., Oldstone, M. B. A., Flavell, R. A. The cd40-cd154 system in anti-infective host defense Current Opinion in Immunology 1997 9:491-497 DOI:10.1016/s0952-7915(97)80100-8 PMID:9287184
- Hudrisier, D., Oldstone, M. B. A., Gairin, J. E. The signal sequence of lymphocytic choriomeningitis virus contains an immunodominant cytotoxic t cell epitope that is restricted by both h-2d(b) and h-2k(b) molecules Virology 1997 234:62-73 DOI:10.1006/viro.1997.8627 PMID:9234947
- Cao, W., Oldstone, M. B. A., DelaTorre, J. C. Viral persistent infection affects both transcriptional and posttranscriptional regulation of neuron-specific molecule GAP43 Virology 1997 230:147-154 DOI:10.1006/viro.1997.8458 PMID:9143270
- Oldstone, M. B. A. Viruses and autoimmune diseases Scandinavian Journal of Immunology 1997 46:320-325 DOI:10.1046/j.1365-3083.1997.d01-145.x PMID:9350280
- Tishon, A., Manchester, M., Scheiflinger, F., Oldstone, M. B. A. A model of measles virus-induced immunosuppression: Enhanced susceptibility of neonatal human pbls Nature Medicine 1996 2:1250-1254 DOI:10.1038/nm1196-1250 PMID:8898755
- Teng, M. N., Borrow, P., Oldstone, M. B. A., delaTorre, J. C. A single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with the ability to cause growth hormone deficiency syndrome Journal of Virology 1996 70:8438-8443 PMID:8970965 PMCID:PMC190933
- delaTorre, J. C., Oldstone, M. B. A. Anatomy of viral persistence: mechanisms of persistence and associated disease Advances in Virus Research 1996 46:311-343 DOI:10.1016/S0065-3527(08)60075-5 PMID:8824703
- Hudrisier, D., Mazarguil, H., Laval, F., Oldstone, M. B. A., Gairin, J. E. Binding of viral antigens to major histocompatibility complex class i h-2d(b) molecules is controlled by dominant negative elements at peptide non-anchor residues - implications for peptide selection and presentation Journal of Biological Chemistry 1996 271:17829-17836 PMID:8663374
- von Herrath, M. G., Yokoyama, M., Dockter, J., Oldstone, M. B. A., Whitton, J. L. Cd4-deficient mice have reduced levels of memory cytotoxic t lymphocytes after immunization and show diminished resistance to subsequent virus challenge Journal of Virology 1996 70:1072-1079 PMID:8551565 PMCID:PMC189913
- Borrow, P., Tishon, A., Lee, S., Xu, J. C., Grewal, I. S., Oldstone, M. B. A., Flavell, R. A. Cd40l-deficient mice show deficits in antiviral immunity and have an impaired memory cd8(+) ctl response Journal of Experimental Medicine 1996 183:2129-2142 DOI:10.1084/jem.183.5.2129 PMID:8642323
- Waters, J. B., Oldstone, M. B. A., Hahn, K. M. Changes in the cytoplasmic structure of ctls during target cell recognition and killing Journal of Immunology 1996 157:3396-3403 PMID:8871637
- Dockter, J., Evans, C. F., Tishon, A., Oldstone, M. B. A. Competitive selection in vivo by a cell for one variant over another: Implications for rna virus quasispecies in vivo Journal of Virology 1996 70:1799-1803 PMID:8627703 PMCID:PMC190006
- von Herrath, M. G., Dyrberg, T., Oldstone, M. B. A. Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice Journal of Clinical Investigation 1996 98:1324-1331 DOI:10.1172/jci118919 PMID:8823297
- Oldstone, M. B. A. Principles of viral pathogenesis Cell 1996 87:799-801 DOI:10.1016/s0092-8674(00)81987-x PMID:8945507
- Steinhauer, D. A., Martin, J., Lin, Y. P., Wharton, S. A., Oldstone, M. B. A., Skehel, J. J., Wiley, D. C. Studies using double mutants of the conformational transitions in influenza hemagglutinin required for its membrane fusion activity Proceedings of the National Academy of Sciences of the United States of America 1996 93:12873-12878 DOI:10.1073/pnas.93.23.12873 PMID:8917512
- Teng, M. N., Oldstone, M. B. A., DelaTorre, J. C. Suppression of lymphocytic choriomeningitis virus-induced growth hormone deficiency syndrome by disease-negative virus variants Virology 1996 223:113-119 DOI:10.1006/viro.1996.0460 PMID:8806545
- Eddleston, M., de la Torre, J. C., Campbell, I. L., Oldstone, M. B. The M22 antibody identifies highly activated reactive astrocytes responding to central nervous system disease Acta Neuropathologica 1996 91:298-308 DOI:10.1007/s004010050429 PMID:8834543
- Lee, M. S., Sawyer, S., Arnush, M., Krahl, T., vonHerrath, M., Oldstone, M. B. A., Sarvetnick, N. Transforming growth factor-beta fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice Transplantation 1996 61:1112-1113 PMID:8623195
- von Herrath, M. G., Evans, C. F., Horwitz, M. S., Oldstone, M. B. A. Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of langerhans and the central nervous system Immunological Reviews 1996 152:111-143 PMID:8930670
- BuesaGomez, J., Teng, M. N., Oldstone, C. E., Oldstone, M. B. A., DelaTorre, J. C. Variants able to cause growth hormone deficiency syndrome are present within the disease-nil WE strain of lymphocytic choriomeningitis virus Journal of Virology 1996 70:8988-8992 PMID:8971029 PMCID:PMC190997
- Guidotti, L. G., Borrow, P., Hobbs, M. V., Matzke, B., Gresser, I., Oldstone, M. B. A., Chisari, F. V. Viral cross talk: Intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver Proceedings of the National Academy of Sciences of the United States of America 1996 93:4589-4594 DOI:10.1073/pnas.93.10.4589 PMID:8643448
- Evans, C. F., Horwitz, M. S., Hobbs, M. V., Oldstone, M. B. A. Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease Journal of Experimental Medicine 1996 184:2371-2384 DOI:10.1084/jem.184.6.2371 PMID:8976191
- delaTorre, J. C., Mallory, M., Brot, M., Gold, L., Koob, G., Oldstone, M. B. A., Masliah, E. Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells Virology 1996 220:508-515 DOI:10.1006/viro.1996.0340 PMID:8661403
- von Herrath, M. G., Oldstone, M. B. A. Virus-induced autoimmune disease Current Opinion in Immunology 1996 8:878-885 DOI:10.1016/S0952-7915(96)80019-7 PMID:8994870
- Oldstone, M. B. A., vonHerrath, M., Evans, C. F., Horwitz, M. S. Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis Current Topics in Microbiology and Immunology 1996 206:67-83 DOI:10.1007/978-3-642-85208-4_5 PMID:8608726
- Oldstone, M. B. A., von Herrath, M. Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and other autoimmune diseases APMIS 1996 104:689-697 DOI:10.1111/j.1699-0463.1996.tb04930.x PMID:8980618
- Tishon, A., Lewicki, H., Rall, G., Vonherrath, M., Oldstone, M. B. A. An essential role for type-1 interferon-gamma in terminating persistent viral-infection Virology 1995 212:244-250 DOI:10.1006/viro.1995.1477 PMID:7676639
- Lewicki, H. A., Vonherrath, M. G., Evans, C. F., Whitton, J. L., Oldstone, M. B. A. CTL escape viral variants. II. Biologic activity in vivo Virology 1995 211:443-450 DOI:10.1006/viro.1995.1426 PMID:7645248
- von Herrath, M. G., Guerder, S., Lewicki, H., Flavell, R. A., Oldstone, M. B. A. Coexpression of b7-1 and viral (''self'') transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes Immunity 1995 3:727-738 DOI:10.1016/1074-7613(95)90062-4 PMID:8777718
- Rall, G. F., Mucke, L., Oldstone, M. B. A. Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo Journal of Experimental Medicine 1995 182:1201-1212 DOI:10.1084/jem.182.5.1201 PMID:7595191 PMCID:PMC2192211
- Lewicki, H., Tishon, A., Borrow, P., Evans, C. F., Gairin, J. E., Hahn, K. M., Jewell, D. A., Wilson, I. A., Oldstone, M. B. A. Ctl escape viral variants .1. Generation and molecular characterization Virology 1995 210:29-40 DOI:10.1006/viro.1995.1314 PMID:7793078
- Oldstone, M. B. A., Lewicki, H., Borrow, P., Hudrisier, D., Gairin, J. E. Discriminated selection among viral peptides with the appropriate anchor residues - implications for the size of the cytotoxic t-lymphocyte repertoire and control of viral-infection Journal of Virology 1995 69:7423-7429 PMID:7494247 PMCID:PMC189679
- Vonherrath, M. G., Allison, J., Miller, Jfap, Oldstone, M. B. A. Focal expression of interleukin-2 does not break unresponsiveness to self (viral) antigen expressed in beta-cells but enhances development of autoimmune-disease (diabetes) after initiation of an anti-self immune-response Journal of Clinical Investigation 1995 95:477-485 DOI:10.1172/jci117688 PMID:7860729
- Borrow, P., Oldstone, M. B. A. Measles-virus - mononuclear cell-interactions Measles Virus 1995 191:85-100 PMID:7789164
- Manchester, M., Valsamakis, A., Kaufman, R., Liszewski, M. K., Alvarez, J., Atkinson, J. P., Lublin, D. M., Oldstone, M. B. A. Measles-virus and c3 binding-sites are distinct on membrane cofactor protein (cd46) Proceedings of the National Academy of Sciences of the United States of America 1995 92:2303-2307 DOI:10.1073/pnas.92.6.2303 PMID:7534417
- Race, R. E., Priola, S. A., Bessen, R. A., Ernst, D., Dockter, J., Rall, G. F., Mucke, L., Chesebro, B., Oldstone, M. B. A. Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent Neuron 1995 15:1183-1191 DOI:10.1016/0896-6273(95)90105-1 PMID:7576660
- Gairin, J. E., Mazarguil, H., Hudrisier, D., Oldstone, M. B. A. Optimal lymphocytic choriomeningitis virus sequences restricted by h-2d(b) major histocompatibility complex class-i molecules and presented to cytotoxic t-lymphocytes Journal of Virology 1995 69:2297-2305 PMID:7533855 PMCID:PMC188900
- Hudrisier, D., Mazarguil, H., Oldstone, M. B. A., Gairin, J. E. Relative implication of peptide residues in binding to major histocompatibility complex class-i h-2d(b) - application to the design of high-affinity, allele-specific peptides Molecular Immunology 1995 32:895-907 DOI:10.1016/0161-5890(95)00043-e PMID:7565816
- Vonherrath, M. G., Oldstone, M. B. A. Role of viruses in the loss of tolerance to self-antigens and in autoimmune-diseases Trends in Microbiology 1995 3:424-430 DOI:10.1016/s0966-842x(00)88995-7 PMID:8574515
- Lee, M. S., Vonherrath, M., Reiser, H., Oldstone, M. B. A., Sarvetnick, N. Sensitization to self (virus) antigen by in-situ expression of murine interferon-gamma Journal of Clinical Investigation 1995 95:486-492 DOI:10.1172/jci117689 PMID:7860730
- Vonherrath, M., Oldstone, M. B. A., Fox, H. S. Simian immunodeficiency virus (siv)-specific ctl in cerebrospinal-fluid and brains of siv-infected rhesus macaques Journal of Immunology 1995 154:5582-5589 PMID:7730657
- Borrow, P., Evans, C. F., Oldstone, M. B. A. Virus-induced immunosuppression - immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression Journal of Virology 1995 69:1059-1070 PMID:7815484 PMCID:PMC188677
- Ada, G., Albrecht, P., Beale, J., Bellini, W. J., Bloom, B., Choppin, P. W., Chu, C. M., Clements, C. J., Cutts, F., Dequadros, C., Gellin, B. G., Griffin, D. E., et al. A Bellagio consensus. Children's Vaccine Initiative Ad Hoc Committe on an investment strategy for measles control Journal of Infectious Diseases 1994 170:S63-S66 DOI:10.1093/infdis/170.Supplement_1.S63 PMID:7930755
- Rall, G. F., Mucke, L., Nerenberg, M., Oldstone, M. B. A. A transgenic mouse model to assess the interaction of cytotoxic t-lymphocytes with virally infected, class-i mhc-expressing astrocytes Journal of Neuroimmunology 1994 52:61-68 DOI:10.1016/0165-5728(94)90163-5 PMID:8207120
- Campbell, I. L., Eddleston, M., Kemper, P., Oldstone, M. B. A., Hobbs, M. V. Activation of cerebral cytokine gene-expression and its correlation with onset of reactive astrocyte and acute-phase response gene-expression in scrapie Journal of Virology 1994 68:2383-2387 PMID:8139024 PMCID:PMC236715
- Hahn, K., Debiasio, R., Tishon, A., Lewicki, H., Gairin, J. E., Larocca, G., Taylor, D. L., Oldstone, M. Antigen presentation and cytotoxic t-lymphocyte killing studied in individual, living cells Virology 1994 201:330-340 DOI:10.1006/viro.1994.1298 PMID:8184542
- Gold, L. H., Brot, M. D., Polis, I., Schroeder, R., Tishon, A., Delatorre, J. C., Oldstone, M. B. A., Koob, G. F. Behavioral-effects of persistent lymphocytic choriomeningitis virus-infection in mice Behavioral and Neural Biology 1994 62:100-109 DOI:10.1016/s0163-1047(05)80031-7 PMID:7993301
- Campbell, I. L., Hobbs, M. V., Kemper, P., Oldstone, M. B. A. Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis Journal of Immunology 1994 152:716-723 PMID:8283046
- Buesagomez, J., Delatorre, J. C., Dyrberg, T., Landinolsson, M., Mauseth, R. S., Lernmark, A., Oldstone, M. B. A. Failure to detect genomic viral sequences in pancreatic tissues from 2 children with acute-onset diabetes-mellitus Journal of Medical Virology 1994 42:193-197 DOI:10.1002/jmv.1890420217 PMID:8158114
- Vonherrath, M. G., Dockter, J., Oldstone, M. B. A. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model Immunity 1994 1:231-242 DOI:10.1016/1074-7613(94)90101-5 PMID:7889411
- Campbell, I. L., Hobbs, M. V., Dockter, J., Oldstone, M. B. A., Allison, J. Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice American Journal of Pathology 1994 145:157-166 PMID:8030746 PMCID:PMC1887304
- Doherty, P. C., Hou, S., Evans, C. F., Whitton, J. L., Oldstone, M. B. A., Blackman, M. A. Limiting the available t-cell receptor repertoire modifies acute lymphocytic choriomeningitis virus-induced immunopathology Journal of Neuroimmunology 1994 51:147-152 DOI:10.1016/0165-5728(94)90076-0 PMID:8182114
- Borrow, P., Oldstone, M. B. A. Mechanism of lymphocytic choriomeningitis virus entry into cells Virology 1994 198:1-9 DOI:10.1006/viro.1994.1001 PMID:8259643
- Manchester, M., Liszewski, M. K., Atkinson, J. P., Oldstone, M. B. A. Multiple isoforms of cd46 (membrane cofactor protein) serve as receptors for measles-virus Proceedings of the National Academy of Sciences of the United States of America 1994 91:2161-2165 DOI:10.1073/pnas.91.6.2161 PMID:8134365
- Lee, M. S., Wogensen, L., Shizuru, J., Oldstone, M. B. A., Sarvetnick, N. Pancreatic-islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction Journal of Clinical Investigation 1994 93:1332-1338 DOI:10.1172/jci117092 PMID:8132775
- Horwitz, M. S., Yanagi, Y., Oldstone, M. B. A. T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity Journal of Virology 1994 68:352-357 PMID:7504738 PMCID:PMC236295
- Vonherrath, M. G., Dockter, J., Nerenberg, M., Gairin, J. E., Oldstone, M. B. A. Thymic selection and adaptability of cytotoxic t-lymphocyte responses in transgenic mice expressing a viral protein in the thymus Journal of Experimental Medicine 1994 180:1901-1910 DOI:10.1084/jem.180.5.1901 PMID:7525843
- Evans, C. F., Borrow, P., Delatorre, J. C., Oldstone, M. B. A. Virus-induced immunosuppression - kinetic-analysis of the selection of a mutation associated with viral persistence Journal of Virology 1994 68:7367-7373 PMID:7933120 PMCID:PMC237179
- Borrow, P., Lewicki, H., Hahn, B. H., Shaw, G. M., Oldstone, M. B. A. Virus-specific cd8+ cytotoxic t-lymphocyte activity associated with control of viremia in primary human-immunodeficiency-virus type-1 infection Journal of Virology 1994 68:6103-6110 PMID:8057491 PMCID:PMC237022
- Whitton, J. L., Sheng, N., Oldstone, M. B. A., McKee, T. A. A string-of-beads vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge Journal of Virology 1993 67:348-352 PMID:7677954 PMCID:PMC237369
- Eddleston, M., Delatorre, J. C., Oldstone, M. B. A., Loskutoff, D. J., Edgington, T. S., Mackman, N. Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis Journal of Clinical Investigation 1993 92:349-358 DOI:10.1172/jci116573 PMID:8326003 PMCID:PMC293611
- Laufer, T. M., Vonherrath, M. G., Grusby, M. J., Oldstone, M. B. A., Glimcher, L. H. Autoimmune diabetes can be induced in transgenic major histocompatibility complex class-ii-deficient mice Journal of Experimental Medicine 1993 178:589-596 DOI:10.1084/jem.178.2.589 PMID:8101862
- Evans, C. F., Rall, G. F., Killeen, N., Littman, D., Oldstone, M. B. A. Cd2-deficient mice generate virus-specific cytotoxic t-lymphocytes upon infection with lymphocytic choriomeningitis virus Journal of Immunology 1993 151:6259-6264 PMID:7902375
- Tishon, A., Eddleston, M., Delatorre, J. C., Oldstone, M. B. A. Cytotoxic T-lymphocytes cleanse viral gene-products from individually infected neurons and lymphocytes in mice persistently infected with lymphocytic choriomeningitis virus Virology 1993 197:463-467 DOI:10.1006/viro.1993.1613 PMID:8212586
- Oldstone, M. B. A., Rall, G. F. Mechanism and consequence of viral persistence in cells of the immune-system and neurons Intervirology 1993 35:116-121 PMID:8407238
- Eddleston, M., Delatorre, J. C., Xu, J. Y., Dorfman, N., Notkins, A., Zollapazner, S., Oldstone, M. B. A. Molecular mimicry accompanying HIV-1 infection - human monoclonal-antibodies that bind to gp41 and to astrocytes AIDS Research and Human Retroviruses 1993 9:939-944 DOI:10.1089/aid.1993.9.939 PMID:7506553
- Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B. A., Mucke, L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin-6 Proceedings of the National Academy of Sciences of the United States of America 1993 90:10061-10065 DOI:10.1073/pnas.90.21.10061 PMID:7694279 PMCID:PMC47713
- Delatorre, J. C., Rall, G., Oldstone, C., Sanna, P. P., Borrow, P., Oldstone, M. B. A. Replication of lymphocytic choriomeningitis virus is restricted in terminally differentiated neurons Journal of Virology 1993 67:7350-7359 PMID:8230458 PMCID:PMC238199
- Oldstone, M. B. A., Southern, P. J. Trafficking of activated cytotoxic t-lymphocytes into the central-nervous-system - use of a transgenic model Journal of Neuroimmunology 1993 46:25-32 DOI:10.1016/0165-5728(93)90230-v PMID:8360331
- Oldstone, M. B. A., Tishon, A., Eddleston, M., Delatorre, J. C., McKee, T., Whitton, J. L. Vaccination to prevent persistent viral infection Journal of Virology 1993 67:4372-4378 PMID:8510226 PMCID:PMC237809
- Gairin, J. E., Oldstone, M. B. A. Virus and cytotoxic t-lymphocytes - crucial role of viral peptide secondary structure in major histocompatibility complex class-i interactions Journal of Virology 1993 67:2903-2907 PMID:7682632 PMCID:PMC237616
- Tishon, A., Borrow, P., Evans, C., Oldstone, M. B. A. Virus-induced immunosuppression .1. Age at infection relates to a selective or generalized defect Virology 1993 195:397-405 DOI:10.1006/viro.1993.1389 PMID:8393233
- Oldstone, M. B. A. Viruses and diseases of the 21st-century American Journal of Pathology 1993 143:1241-1249 PMID:8238240 PMCID:PMC1887167
- Littaua, R. A., Oldstone, M. B. A., Takeda, A., Ennis, F. A. A cd4+ cytotoxic lymphocyte-t clone to a conserved epitope on human-immunodeficiency-virus type-1 p24 - cytotoxic activity and secretion of interleukin-2 and interleukin-6 Journal of Virology 1992 66:608-611 PMID:1370094
- Oldstone, M. B. A., Tishon, A., Geckeler, R., Lewicki, H., Whitton, J. L. A common antiviral cytotoxic lymphocyte-t epitope for diverse major histocompatibility complex haplotypes - implications for vaccination Proceedings of the National Academy of Sciences of the United States of America 1992 89:2752-2755 DOI:10.1073/pnas.89.7.2752 PMID:1372990
- Borrow, P., Oldstone, M. B. A. Characterization of lymphocytic choriomeningitis virus-binding protein(s) - a candidate cellular receptor for the virus Journal of Virology 1992 66:7270-7281 PMID:1331520 PMCID:PMC240431
- Gairin, J. E., Oldstone, M. B. A. Design of high-affinity major histocompatibility complex-specific antagonist peptides that inhibit cytotoxic lymphocyte-t activity - implications for control of viral disease Journal of Virology 1992 66:6755-6762 PMID:1383569 PMCID:PMC240172
- Yanagi, Y., Tishon, A., Lewicki, H., Cubitt, B. A., Oldstone, M. B. A. Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule Journal of Virology 1992 66:2527-2531 PMID:1372370 PMCID:PMC289052
- Lohr, M., Bergstrome, B., Maekawa, R., Oldstone, M. B. A., Kloppel, G. Human cytomegalovirus in the pancreas of patients with type-2 diabetes - is there a relation to clinical-features, messenger-rna and protein expression of insulin, somatostatin, and mhc class-ii Virchows Archiv A-Pathological Anatomy and Histopathology 1992 421:371-378 DOI:10.1007/bf01606908 PMID:1360719
- Yanagi, Y., Cubitt, B. A., Oldstone, M. B. A. Measles-virus inhibits mitogen-induced t-cell proliferation but does not directly perturb the t-cell activation process inside the cell Virology 1992 187:280-289 DOI:10.1016/0042-6822(92)90316-h PMID:1736530
- Joly, E., Oldstone, M. B. A. Neuronal cells are deficient in loading peptides onto mhc class-i molecules Neuron 1992 8:1185-1190 DOI:10.1016/0896-6273(92)90138-4 PMID:1610569
- Lewicki, H., McKee, T. A., Tishon, A., Salvato, M., Whitton, J. L., Oldstone, M. B. A. Novel lcmv-specific h-2k restricted ctl clones recognize internal viral gene-products and cause cns disease Journal of Neuroimmunology 1992 41:15-20 DOI:10.1016/0165-5728(92)90190-v PMID:1281166
- Wirth, J. J., Amalfitano, A., Gross, R., Oldstone, M. B. A., Fluck, M. M. Organ-specific and age-specific replication of polyomavirus in mice Journal of Virology 1992 66:3278-3286 PMID:1316447 PMCID:PMC241105
- Delatorre, J. C., Oldstone, M. B. A. Selective disruption of growth-hormone transcription machinery by viral-infection Proceedings of the National Academy of Sciences of the United States of America 1992 89:9939-9943 PMID:1409723 PMCID:PMC50249
- Mucke, L., Oldstone, M. B. A. The expression of major histocompatibility complex (mhc) class-i antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (lcmv) Journal of Neuroimmunology 1992 36:193-198 DOI:10.1016/0165-5728(92)90050-u PMID:1732281
- Littaua, R. A., Oldstone, M. B. A., Takeda, A., Debouck, C., Wong, J. T., Tuazon, C. U., Moss, B., Kievits, F., Ennis, F. A. An hla-c-restricted cd8+ cytotoxic lymphocyte-t clone recognizes a highly conserved epitope on human-immunodeficiency-virus type-1 gag Journal of Virology 1991 65:4051-4056 PMID:1712857 PMCID:PMC248836
- Yamada, M., Zurbriggen, A., Oldstone, M. B. A., Fujinami, R. S. Common immunological determinant between human-immunodeficiency-virus type-1 gp41 and astrocytes Journal of Virology 1991 65:1370-1376 PMID:1704927 PMCID:PMC239914
- Joly, E., Oldstone, M. B. A. Generation of a functional cdna-encoding the ldh2 class-i molecule by using a single-ltr retroviral shuttle vector Gene 1991 97:213-221 DOI:10.1016/0378-1119(91)90054-f PMID:1705528
- Borrow, P., Tishon, A., Oldstone, M. B. A. Infection of lymphocytes by a virus that aborts cytotoxic lymphocyte-t activity and establishes persistent infection Journal of Experimental Medicine 1991 174:203-212 DOI:10.1084/jem.174.1.203 PMID:1905339
- Joly, E., Oldstone, M. B. A. Manufacture of a functional cdna for the h-2db molecule using a retroviral shuttle vector Immunogenetics 1991 34:62-65 DOI:10.1007/bf00212315 PMID:1713192
- Oldstone, M. B. A., Tishon, A., Lewicki, H., Dyson, H. J., Feher, V. A., Assamunt, N., Wright, P. E. Mapping the anatomy of the immunodominant domain of the human immunodeficiency virus gp41 transmembrane protein: peptide conformation analysis using monoclonal antibodies and proton nuclear magnetic resonance spectroscopy Journal of Virology 1991 65:1727-1734 PMID:2002540 PMCID:PMC239977
- Oldstone, M. B. A. Molecular anatomy of viral persistence Journal of Virology 1991 65:6381-6386 PMID:1719227 PMCID:PMC250674
- Salvato, M., Borrow, P., Shimomaye, E., Oldstone, M. B. A. Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence Journal of Virology 1991 65:1863-1869 PMID:1840619 PMCID:PMC239996
- Gairin, J. E., Joly, E., Oldstone, M. B. A. Persistent infection with lymphocytic choriomeningitis virus enhances expression of mhc class-i glycoprotein on cultured mouse-brain endothelial-cells Journal of Immunology 1991 146:3953-3957 PMID:2033264
- Mucke, L., Oldstone, M. B. A., Morris, J. C., Nerenberg, M. I. Rapid activation of astrocyte-specific expression of gfap-lacz transgene by focal injury New Biologist 1991 3:465-474 PMID:1883812
- Tishon, A., Salmi, A., Ahmed, R., Oldstone, M. B. A. Role of viral strains and host genes in determining levels of immune-complexes in a model system - implications for hiv-infection AIDS Research and Human Retroviruses 1991 7:963-969 DOI:10.1089/aid.1991.7.963 PMID:1812945
- Delatorre, J. C., Borrow, P., Oldstone, M. B. A. Viral persistence and disease - cytopathology in the absence of cytolysis British Medical Bulletin 1991 47:838-851 PMID:1794088
- Joly, E., Mucke, L., Oldstone, M. B. A. Viral persistence in neurons explained by lack of major histocompatibility class-1 expression Science 1991 253:1283-1285 DOI:10.1126/science.1891717 PMID:1891717
- Oldstone, M. B. A., Nerenberg, M., Southern, P., Price, J., Lewicki, H. Virus-infection triggers insulin-dependent diabetes-mellitus in a transgenic model - role of anti-self (virus) immune-response Cell 1991 65:319-331 DOI:10.1016/0092-8674(91)90165-u PMID:1901765
- Lathey, J. L., Agosti, J. M., Nelson, J. A., Corey, L., Gregory, S. A., Morrissey, J. H., Edgington, T. S., Oldstone, M. B. A. A selective defect in tissue factor messenger-rna expression in monocytes from aids patients Clinical Immunology and Immunopathology 1990 54:1-13 DOI:10.1016/0090-1229(90)90001-7 PMID:2293902
- Oldstone, M. B. A., Tishon, A., Schwimmbeck, P. L., Shyp, S., Lewicki, H., Dyrberg, T. Cytotoxic lymphocytes-t do not control lymphocytic choriomeningitis virus-infection of bb diabetes-prone rats Journal of General Virology 1990 71:785-791 DOI:10.1099/0022-1317-71-4-785 PMID:2324708
- Lohr, J. M., Oldstone, M. B. A. Detection of cytomegalovirus nucleic-acid sequences in pancreas in type-2 diabetes Lancet 1990 336:644-648 DOI:10.1016/0140-6736(90)92145-8 PMID:1975850
- Dyrberg, T., Petersen, J. S., Oldstone, M. B. A. Immunological cross-reactivity between mimicking epitopes on a virus protein and a human autoantigen depends on a single amino-acid residue Clinical Immunology and Immunopathology 1990 54:290-297 DOI:10.1016/0090-1229(90)90090-d PMID:1688524
- Shyp, S., Tishon, A., Oldstone, M. B. A. Inhibition of diabetes in bb rats by virus-infection .2. Effect of virus-infection on the immune-response to nonviral and viral-antigens Immunology 1990 69:501-507 PMID:2335372 PMCID:PMC1385619
- Lohr, J. M., Nelson, J. A., Oldstone, M. B. A. Is herpes-simplex virus associated with peptic-ulcer disease Journal of Virology 1990 64:2168-2174 PMID:2157877 PMCID:PMC249375
- Tishon, A., Oldstone, M. B. A. Perturbation of differentiated functions during viral infection in vivo. In vivo relationship of host genes and lymphocytic choriomeningitis virus to growth hormone deficiency American Journal of Pathology 1990 137:965-969 PMID:2221020 PMCID:PMC1877543
- Yanagi, Y., Maekawa, R., Cook, T., Kanagawa, O., Oldstone, M. B. A. Restricted v-segment usage in t-cell receptors from cytotoxic lymphocytes-t specific for a major epitope of lymphocytic choriomeningitis virus Journal of Virology 1990 64:5919-5926 PMID:1700830 PMCID:PMC248763
- Gnann, J. W., Oldstone, M. B. A. Using synthetic peptide reagents to distinguish infections caused by different hiv strains Current Topics in Microbiology and Immunology 1990 160:131-143 PMID:2191839
- Klavinskis, L. S., Whitton, J. L., Joly, E., Oldstone, M. B. A. Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope Virology 1990 178:393-400 DOI:10.1016/0042-6822(90)90336-p PMID:1699348
- Oldstone, M. B. A. Viral persistence and immune dysfunction Hospital Practice 1990 25:81-85, 88, 91 passim PMID:2110177
- Oldstone, M. B. A. Viruses as therapeutic agents .1. Treatment of nonobese insulin-dependent diabetes mice with virus prevents insulin-dependent diabetes-mellitus while maintaining general immune competence Journal of Experimental Medicine 1990 171:2077-2089 DOI:10.1084/jem.171.6.2077 PMID:1972180
- Oldstone, M. B. A., Ahmed, R., Salvato, M. Viruses as therapeutic agents .2. Viral reassortants map prevention of insulin-dependent diabetes-mellitus to the small rna of lymphocytic choriomeningitis virus Journal of Experimental Medicine 1990 171:2091-2100 DOI:10.1084/jem.171.6.2091 PMID:2191074
- Whitton, J. L., Oldstone, M. B. A. Class-i mhc can present an endogenous peptide to cyto-toxic lymphocytes-t Journal of Experimental Medicine 1989 170:1033-1038 DOI:10.1084/jem.170.3.1033 PMID:2475568
- Husby, G., Tsuchiya, N., Schwimmbeck, P. L., Keat, A., Pahle, J. A., Oldstone, M. B. A., Williams, R. C. Cross-reactive epitope with klebsiella-pneumoniae nitrogenase in articular tissue of hla-b27+ patients with ankylosing-spondylitis Arthritis and Rheumatism 1989 32:437-445 DOI:10.1002/anr.1780320413 PMID:2468338
- Gnann, J. W., Smith, L. L., Oldstone, M. B. A. Custom-designed synthetic peptide immunoassays for distinguishing hiv type-1 and type-2 infections Methods in Enzymology 1989 178:693-714 PMID:2481220
- Klavinskis, L. S., Geckeler, R., Oldstone, M. B. A. Cytotoxic T lymphocyte control of acute lymphocytic choriomeningitis virus infection: interferon gamma, but not tumour necrosis factor alpha, displays antiviral activity in vivo Journal of General Virology 1989 70:3317-3325 DOI:10.1099/0022-1317-70-12-3317 PMID:2514255
- Klavinskis, L. S., Tishon, A., Oldstone, M. B. A. Efficiency and effectiveness of cloned virus-specific cytotoxic T lymphocytes in vivo Journal of Immunology 1989 143:2013-2016 PMID:2476492
- Chang, C. P., Vesole, D. H., Nelson, J., Oldstone, M. B. A., Stinski, M. F. Identification and expression of a human cytomegalo-virus early glycoprotein Journal of Virology 1989 63:3330-3337 PMID:2545908 PMCID:PMC250906
- Young, L. H. Y., Klavinskis, L. S., Oldstone, M. B. A., Young, J. D. E. In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection Journal of Experimental Medicine 1989 169:2159-2171 DOI:10.1084/jem.169.6.2159 PMID:2471775 PMCID:PMC2189355
- Schwimmbeck, P. L., Oldstone, M. B. A. Klebsiella pneumoniae and hla-b27-associated diseases of reiters-syndrome and ankylosing-spondylitis Current Topics in Microbiology and Immunology 1989 145:45-56 PMID:2680296
- Klavinskis, L. S., Oldstone, M. B. A. Lymphocytic choriomeningitis virus selectively alters differentiated but not housekeeping functions - block in expression of growth-hormone gene is at the level of transcriptional initiation Virology 1989 168:232-235 DOI:10.1016/0042-6822(89)90262-6 PMID:2916325
- Whitton, J. L., Tishon, A., Lewicki, H., Gebhard, J., Cook, T., Salvato, M., Joly, E., Oldstone, M. B. A. Molecular analyses of a 5-amino-acid cyto-toxic lymphocyte-t (ctl) epitope - an immunodominant region which induces nonreciprocal ctl cross-reactivity Journal of Virology 1989 63:4303-4310 PMID:2476570 PMCID:PMC251046
- Schwimmbeck, P. L., Dyrberg, T., Drachman, D. B., Oldstone, M. B. A. Molecular mimicry and myasthenia-gravis - an autoantigenic site of the acetylcholine-receptor alpha-subunit that has biologic activity and reacts immunochemically with herpes-simplex virus Journal of Clinical Investigation 1989 84:1174-1180 DOI:10.1172/jci114282 PMID:2551924
- Oldstone, M. B. A. Molecular mimicry as a mechanism for the cause and as a probe uncovering etiologic agent(s) of autoimmune-disease Current Topics in Microbiology and Immunology 1989 145:127-135 PMID:2805785
- Fujinami, R. S., Oldstone, M. B. A. Molecular mimicry as a mechanism for virus-induced autoimmunity Immunologic Research 1989 8:3-15 DOI:10.1007/bf02918552 PMID:2647867
- Klavinskis, L. S., Whitton, J. L., Oldstone, M. B. A. Molecularly engineered vaccine which expresses an immunodominant t-cell epitope induces cyto-toxic lymphocytes-t that confer protection from lethal virus-infection Journal of Virology 1989 63:4311-4316 PMID:2476571 PMCID:PMC251047
- Joly, E., Salvato, M., Whitton, J. L., Oldstone, M. B. A. Polymorphism of cyto-toxic lymphocyte-t clones that recognize a defined 9-amino-acid immunodominant domain of lymphocytic choriomeningitis virus glycoprotein Journal of Virology 1989 63:1845-1851 PMID:2467990 PMCID:PMC250594
- Schrier, R. D., Gnann, J. W., Landes, R., Lockshin, C., Richman, D., McCutchan, A., Kennedy, C., Oldstone, M. B. A., Nelson, J. A. T-cell recognition of hiv synthetic peptides in a natural infection Journal of Immunology 1989 142:1166-1176 PMID:2783706
- Salvato, M., Shimomaye, E., Oldstone, M. B. A. The primary structure of the lymphocytic choriomeningitis virus l-gene encodes a putative rna-polymerase Virology 1989 169:377-384 DOI:10.1016/0042-6822(89)90163-3 PMID:2705303
- Oldstone, M. B. A. Viral alteration of cell function Scientific American 1989 261:42-48 PMID:2569234
- Oldstone, M. B. A. Viral persistence Cell 1989 56:517-520 DOI:10.1016/0092-8674(89)90573-4 PMID:2645053
- Oldstone, M. B. A. Virus-induced autoimmunity: molecular mimicry as a route to autoimmune disease Journal of Autoimmunity 1989 2:187-194 DOI:10.1016/0896-8411(89)90130-3 PMID:2673272
- McChesney, M. B., Fujinami, R. S., Lerche, N. W., Marx, P. A., Oldstone, M. B. A. Virus-induced immunosuppression - infection of peripheral-blood mononuclear-cells and suppression of immunoglobulin-synthesis during natural measles-virus infection of rhesus-monkeys Journal of Infectious Diseases 1989 159:757-760 PMID:2784472
- McChesney, M. B., Oldstone, M. B. A. Virus-induced immunosuppression: infections with measles virus and human immunodeficiency virus Advances in Immunology 1989 45:335-380 DOI:10.1016/S0065-2776(08)60696-3 PMID:2665441
- Oldstone, M. B. A. Viruses can cause disease in the absence of morphological evidence of cell injury - implication for uncovering new diseases in the future Journal of Infectious Diseases 1989 159:384-389 PMID:2644376
- Lipkin, W. I., Villarreal, L. P., Oldstone, M. B. A. Whole animal section insitu hybridization and protein blotting - new tools in molecular analysis of animal-models for human-disease Current Topics in Microbiology and Immunology 1989 143:33-54 PMID:2670459
- Schwimmbeck, P. L., Dyrberg, T., Oldstone, M. B. A. Abrogation of diabetes in bb rats by acute virus-infection - association of viral-lymphocyte interactions Journal of Immunology 1988 140:3394-3400 PMID:3283232
- Whitton, J. L., Southern, P. J., Oldstone, M. B. A. Analyses of the cyto-toxic lymphocyte-t responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus Virology 1988 162:321-327 DOI:10.1016/0042-6822(88)90471-0 PMID:3257596
- Lipkin, W. I., Schwimmbeck, P. L., Oldstone, M. B. A. Antibody to synthetic somatostatin-28(1-12) - immunoreactivity with somatostatin in brain is dependent on orientation of immunizing peptide Journal of Histochemistry & Cytochemistry 1988 36:447-451 PMID:2450123
- Schrier, R. D., Gnann, J. W., Langlois, A. J., Shriver, K., Nelson, J. A., Oldstone, M. B. A. B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus Journal of Virology 1988 62:2531-2536 PMID:3260630 PMCID:PMC253681
- Oldstone, M. B. A., Whitton, J. L., Lewicki, H., Tishon, A. Fine dissection of a 9 amino-acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class-i-restricted h-2db cyto-toxic lymphocytes-t Journal of Experimental Medicine 1988 168:559-570 DOI:10.1084/jem.168.2.559 PMID:2457647
- Nelson, J. A., Reynoldskohler, C., Oldstone, M. B. A., Wiley, C. A. Hiv and hcmv coinfect brain-cells in patients with aids Virology 1988 165:286-290 DOI:10.1016/0042-6822(88)90685-x PMID:2838967
- Gnann, J. W., Ahlmen, J., Svalander, C., Olding, L., Oldstone, M. B. A., Nelson, J. A. Inflammatory cells in transplanted kidneys are infected by human cytomegalo-virus American Journal of Pathology 1988 132:239-248 PMID:2840830 PMCID:PMC1880719
- Dyrberg, T., Schwimmbeck, P. L., Oldstone, M. B. A. Inhibition of diabetes in bb rats by virus-infection Journal of Clinical Investigation 1988 81:928-931 DOI:10.1172/jci113405 PMID:3343348
- Whitton, J. L., Gebhard, J. R., Lewicki, H., Tishon, A., Oldstone, M. B. A. Molecular definition of a major cyto-toxic lymphocyte-t epitope in the glycoprotein of lymphocytic choriomeningitis virus Journal of Virology 1988 62:687-695 PMID:2448497 PMCID:PMC253621
- Schwimmbeck, P. L., Oldstone, M. B. A. Molecular mimicry between human-leukocyte antigen b27 and klebsiella - consequences for spondyloarthropathies American Journal of Medicine 1988 85:51-53 DOI:10.1016/0002-9343(88)90385-3
- Lipkin, W. I., Carbone, K. M., Wilson, M. C., Duchala, C. S., Narayan, O., Oldstone, M. B. A. Neurotransmitter abnormalities in borna disease Brain Research 1988 475:366-370 DOI:10.1016/0006-8993(88)90627-0 PMID:2905625
- Ahmed, R., Oldstone, M. B. A. Organ-specific selection of viral variants during chronic infection Journal of Experimental Medicine 1988 167:1719-1724 DOI:10.1084/jem.167.5.1719 PMID:3367096
- Klavinskis, L. S., Notkins, A. L., Oldstone, M. B. A. Persistent viral-infection of the thyroid-gland - alteration of thyroid-function in the absence of tissue-injury Endocrinology 1988 122:567-575 PMID:3338413
- Oldstone, M. B. A. Prevention of type-i diabetes in nonobese diabetic mice by virus-infection Science 1988 239:500-502 DOI:10.1126/science.3277269 PMID:3277269
- Fujinami, R. S., Nelson, J. A., Walker, L., Oldstone, M. B. A. Sequence homology and immunological cross-reactivity of human cytomegalo-virus with hla-dr beta-chain - a means for graft-rejection and immunosuppression Journal of Virology 1988 62:100-105 PMID:2446012 PMCID:PMC250506
- McChesney, M. B., Altman, A., Oldstone, M. B. A. Suppression of lymphocyte-t function by measles-virus is due to cell-cycle arrest in g1 Journal of Immunology 1988 140:1269-1273 PMID:2449499
- Lipkin, W. I., Battenberg, E. L. F., Bloom, F. E., Oldstone, M. B. A. Viral infection of neurons can depress neurotransmitter mRNA levels without histologic injury Brain Research 1988 451:333-339 DOI:10.1016/0006-8993(88)90779-2 PMID:2908027
- Oldstone, M. B. A., Salvato, M., Tishon, A., Lewicki, H. Virus lymphocyte interactions .3. Biologic parameters of a virus variant that fails to generate ctl and establishes persistent infection in immunocompetent hosts Virology 1988 164:507-516 DOI:10.1016/0042-6822(88)90565-x PMID:2967012
- Salvato, M., Shimomaye, E., Southern, P., Oldstone, M. B. A. Virus lymphocyte interactions .4. Molecular characterization of lcmv armstrong (ctl+) small genomic segment and that of its variant, clone-13 (ctl-) Virology 1988 164:517-522 DOI:10.1016/0042-6822(88)90566-1 PMID:3259346
- Tishon, A., Southern, P. J., Oldstone, M. B. A. Virus-lymphocyte interactions .2. Expression of viral sequences during the course of persistent lymphocytic choriomeningitis virus-infection and their localization to the lymphocyte-l3t4 subset Journal of Immunology 1988 140:1280-1284 PMID:2963865
- Lathey, J. L., Oldstone, M. B. A. Weight-loss in obese mice persistently infected with lymphocytic choriomeningitis virus is not associated with elevated tumor necrosis factor cachectin activity in peritoneal-macrophages American Journal of Pathology 1988 132:586-592 PMID:3414785 PMCID:PMC1880743
- Chen, J. H., Kono, D. H., Yong, Z., Park, M. S., Oldstone, Mmba, Yu, D. T. Y. A Yersinia-pseudotuberculosis protein which cross-reacts with HLA-B27 Journal of Immunology 1987 139:3003-3011 PMID:2444647
- Schwimmbeck, P. L., Yu, D. T. Y., Oldstone, M. B. A. Autoantibodies to hla b27 in the sera of hla b27 patients with ankylosing-spondylitis and reiters-syndrome - molecular mimicry with klebsiella-pneumoniae as potential mechanism of autoimmune-disease Journal of Experimental Medicine 1987 166:173-181 DOI:10.1084/jem.166.1.173 PMID:2439632
- Gnann, J. W., Schwimmbeck, P. L., Nelson, J. A., Truax, A. B., Oldstone, M. B. A. Diagnosis of aids by using a 12-amino acid peptide representing an immunodominant epitope of the human-immunodeficiency-virus Journal of Infectious Diseases 1987 156:261-267 PMID:2439614
- Gnann, J. W., Nelson, J. A., Oldstone, M. B. A. Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human-immunodeficiency-virus Journal of Virology 1987 61:2639-2641 PMID:2439707 PMCID:PMC255715
- Oldstone, M. B. A. Immunotherapy for virus-infection Current Topics in Microbiology and Immunology 1987 134:211-221 PMID:3495409
- Klavinskis, L. S., Oldstone, M. B. A. Lymphocytic choriomeningitis virus can persistently infect thyroid epithelial-cells and perturb thyroid-hormone production Journal of General Virology 1987 68:1867-1873 DOI:10.1099/0022-1317-68-7-1867 PMID:3598562
- McChesney, M. B., Kehrl, J. H., Valsamakis, A., Fauci, A. S., Oldstone, M. B. A. Measles-virus infection of lymphocytes-b permits cellular activation but blocks progression through the cell-cycle Journal of Virology 1987 61:3441-3447 PMID:3499518 PMCID:PMC255940
- Oldstone, M. B. A. Molecular basis of viral persistence AIDS Research and Human Retroviruses 1987 3:207-211 DOI:10.1089/aid.1987.3.207 PMID:3318885
- Southern, P. J., Singh, M. K., Riviere, Y., Jacoby, D. R., Buchmeier, M. J., Oldstone, M. B. A. Molecular characterization of the genomic-s rna segment from lymphocytic choriomeningitis virus Virology 1987 157:145-155 DOI:10.1016/0042-6822(87)90323-0 PMID:3824905
- Oldstone, M. B. A. Molecular mimicry and autoimmune-disease Cell 1987 50:819-820 DOI:10.1016/0092-8674(87)90507-1 PMID:3621346
- Patterson, S., Byrne, J. A., Lampert, P. W., Oldstone, M. B. A. Morphological analysis of the interactions between lymphocytic choriomeningitis virus-specific cloned cytotoxic t-cells and virus-infected targets Laboratory Investigation 1987 57:29-36 PMID:3496491
- Tishon, A., Oldstone, M. B. A. Persistent virus infection associated with chemical manifestations of diabetes. II. Role of viral strain, environmental insult, and host genetics American Journal of Pathology 1987 126:61-72 PMID:2949622 PMCID:PMC1899557
- Valsamakis, A., Riviere, Y., Oldstone, M. B. A. Perturbation of differentiated functions in vivo during persistent viral infection. III. Decreased growth hormone mRNA Virology 1987 156:214-220 DOI:10.1016/0042-6822(87)90400-4 PMID:3811236
- Buchmeier, M. J., Southern, P. J., Parekh, B. S., Wooddell, M. K., Oldstone, M. B. A. Site-specific antibodies define a cleavage site conserved among arenavirus gp-c glycoproteins Journal of Virology 1987 61:982-985 PMID:3546729 PMCID:PMC254053
- Francis, S. J., Southern, P. J., Valsamakis, A., Oldstone, M. B. A. State of viral genome and proteins during persistent lymphocytic choriomeningitis virus-infection Current Topics in Microbiology and Immunology 1987 133:67-88 PMID:2435462
- Gnann, J. W., McCormick, J. B., Mitchell, S., Nelson, J. A., Oldstone, M. B. A. Synthetic peptide immunoassay distinguishes hiv type-1 and hiv type-2 infections Science 1987 237:1346-1349 DOI:10.1126/science.2888192 PMID:2888192
- Oldstone, M. B. A. The arenaviruses: an introduction Current Topics in Microbiology and Immunology 1987 134:1-4 DOI:10.1007/978-3-642-71726-0_1 PMID:3581897
- Ahmed, R., King, C. C., Oldstone, M. B. A. Virus-lymphocyte interaction: T cells of the helper subset are infected with lymphocytic choriomeningitis virus during persistent infection in vivo Journal of Virology 1987 61:1571-1576 PMID:2952807 PMCID:PMC254137
- McChesney, M. B., Oldstone, M. B. A. Viruses perturb lymphocyte functions - selected principles characterizing virus-induced immunosuppression Annual Review of Immunology 1987 5:279-304 DOI:10.1146/annurev.immunol.5.1.279 PMID:3036182
- Lipkin, W. I., Oldstone, M. B. A. Analysis of endogenous and exogenous antigens in the nervous-system using whole animal sections Journal of Neuroimmunology 1986 11:251-257 PMID:2420825
- Francis, S. J., Singh, M. K., Oldstone, M. B. A., Southern, P. J. Analysis of lymphocytic choriomeningitis virus gene expression in acutely and persistently infected mice Medical Microbiology and Immunology 1986 175:105-108 DOI:10.1007/bf02122426 PMID:3724658
- Riviere, Y., Southern, P. J., Ahmed, R., Oldstone, M. B. A. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. V. Recognition is restricted to gene products encoded by the viral S RNA segment Journal of Immunology 1986 136:304-307 PMID:3484391
- Byrne, J. A., Oldstone, M. B. A. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. VI. Migration and activity in vivo in acute and persistent infection Journal of Immunology 1986 136:698-704 PMID:2416821
- Wiley, C. A., Schrier, R. D., Nelson, J. A., Lampert, P. W., Oldstone, M. B. A. Cellular-localization of human immunodeficiency virus-infection within the brains of acquired-immune-deficiency-syndrome patients Proceedings of the National Academy of Sciences of the United States of America 1986 83:7089-7093 DOI:10.1073/pnas.83.18.7089 PMID:3018755
- Oldstone, M. B. A., Blount, P., Southern, P. J., Lampert, P. W. Cytoimmunotherapy for persistent virus-infection reveals a unique clearance pattern from the central-nervous-system Nature 1986 321:239-243 DOI:10.1038/321239a0 PMID:3086743
- Valsamakis, V., Southern, P., Blount, P., Ahmed, R., Buchmeier, M. J., Oldstone, M. B. A. Dissecting the molecular anatomy of persistent infection with lymphocytic choriomeningitis virus Medical Microbiology and Immunology 1986 175:97-99 DOI:10.1007/bf02122424 PMID:3724670
- Blount, P., Elder, J., Lipkin, W. I., Southern, P. J., Buchmeier, M. J., Oldstone, M. B. A. Dissecting the molecular anatomy of the nervous system: analysis of RNA and protein expression in whole body sections of laboratory animals Brain Research 1986 382:257-265 DOI:10.1016/0006-8993(86)91335-1 PMID:2428441
- Oldstone, M. B. A. Distortion of cell functions by noncytotoxic viruses Hospital Practice 1986 21:82-92 PMID:3088015
- Riviere, Y., Oldstone, M. B. A. Genetic reassortants of lymphocytic choriomeningitis virus - unexpected disease and mechanism of pathogenesis Journal of Virology 1986 59:363-368 PMID:2426464 PMCID:PMC253085
- Wiley, C. A., Schrier, R. D., Denaro, F. J., Nelson, J. A., Lampert, P. W., Oldstone, M. B. A. Localization of cytomegalovirus proteins and genome during fulminant central-nervous-system infection in an aids patient Journal of Neuropathology and Experimental Neurology 1986 45:127-140 DOI:10.1097/00005072-198603000-00003 PMID:3005516
- Buchmeier, M. J., Southern, P. J., Parekh, B. S., Oldstone, M. B. A. Molecular and topographic analysis of the glycoproteins of lymphocytic choriomeningitis virus Medical Microbiology and Immunology 1986 175:71-72 DOI:10.1007/bf02122418 PMID:2425233
- Srinivasappa, J., Saegusa, J., Prabhakar, B. S., Gentry, M. K., Buchmeier, M. J., Wiktor, T. J., Koprowski, H., Oldstone, M. B. A., Notkins, A. L. Molecular mimicry - frequency of reactivity of monoclonal antiviral antibodies with normal-tissues Journal of Virology 1986 57:397-401 PMID:3753614 PMCID:PMC252745
- Dyrberg, T., Oldstone, M. B. A. Peptides as antigens - importance of orientation Journal of Experimental Medicine 1986 164:1344-1349 DOI:10.1084/jem.164.4.1344 PMID:3760779
- Dyrberg, T., Oldstone, M. B. A. Peptides as probes to study molecular mimicry and virus-induced autoimmunity Current Topics in Microbiology and Immunology 1986 130:25-37 PMID:3536327
- Klavinskis, L. S., Oldstone, M. B. A. Perturbation of endocrine functions during persistent infection of mice with lymphocytic choriomeningitis virus Medical Microbiology and Immunology 1986 175:117-119 DOI:10.1007/bf02122429 PMID:3724660
- Schrier, R. D., Oldstone, M. B. A. Recent clinical isolates of cytomegalovirus suppress human cytomegalovirus-specific human-leukocyte antigen-restricted cytotoxic lymphocyte-t activity Journal of Virology 1986 59:127-131 PMID:3012111 PMCID:PMC253047
- Schrier, R. D., Rice, G. P. A., Oldstone, M. B. A. Suppression of natural-killer cell-activity and t-cell proliferation by fresh isolates of human cytomegalovirus Journal of Infectious Diseases 1986 153:1084-1091 PMID:2422296
- Riviere, Y., Ahmed, R., Oldstone, M. B. A. The use of lymphocytic choriomeningitis virus reassortants to map viral genes causing virulence Medical Microbiology and Immunology 1986 175:191-192 DOI:10.1007/bf02122448 PMID:3724665
- McChesney, M. B., Fujinami, R. S., Lampert, P. W., Oldstone, M. B. A. Viruses disrupt functions of human-lymphocytes .2. Measles-virus suppresses antibody-production by acting on lymphocytes-b Journal of Experimental Medicine 1986 163:1331-1336 PMID:3486248 PMCID:PMC2188085
- Fujinami, R. S., Oldstone, M. B. A. Amino-acid homology between the encephalitogenic site of myelin basic-protein and virus - mechanism for autoimmunity Science 1985 230:1043-1045 DOI:10.1126/science.2414848 PMID:2414848
- Anderson, J., Byrne, J. A., Schreiber, R., Patterson, S., Oldstone, M. B. A. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus and in vitro properties Journal of Virology 1985 53:552-560 PMID:3918175 PMCID:PMC254670
- Sissons, J. G. P., Colby, S. D., Harrison, W. O., Oldstone, M. B. A. Cytotoxic lymphocytes generated in vivo with acute measles virus infection Clinical Immunology and Immunopathology 1985 34:60-68 DOI:10.1016/0090-1229(85)90007-8 PMID:3871183
- Schrier, R. D., Nelson, J. A., Oldstone, M. B. A. Detection of human cytomegalo-virus in peripheral-blood lymphocytes in a natural infection Science 1985 230:1048-1051 DOI:10.1126/science.2997930 PMID:2997930
- Riviere, Y., Ahmed, R., Southern, P. J., Buchmeier, M. J., Oldstone, M. B. A. Genetic-mapping of lymphocytic choriomeningitis virus pathogenicity - virulence in guinea-pigs is associated with the l rna segment Journal of Virology 1985 55:704-709 PMID:4020963 PMCID:PMC255050
- Rice, G. P. A., Woelfel, E. L., Talbot, P. J., Braheny, S. L., Sipe, J. C., Knobler, R. L., Merigan, T. C., Oldstone, M. B. A. Immunological complications in multiple-sclerosis patients receiving interferon Annals of Neurology 1985 18:439-442 DOI:10.1002/ana.410180405 PMID:2416266
- Oldstone, M. B. A., Ahmed, R., Buchmeier, M. J., Blount, P., Tishon, A. Perturbation of differentiated functions during viral infection in vivo. I. Relationship of lymphocytic choriomeningitis virus and host strains to growth hormone deficiency Virology 1985 142:158-174 DOI:10.1016/0042-6822(85)90430-1 PMID:2414901
- Riviere, Y., Ahmed, R., Southern, P., Oldstone, M. B. A. Perturbation of differentiated functions during viral infection in vivo. II. Viral reassortants map growth hormone defect to the S RNA of the lymphocytic choriomeningitis virus genome Virology 1985 142:175-182 DOI:10.1016/0042-6822(85)90431-3 PMID:4060570
- Riviere, Y., Ahmed, R., Southern, P. J., Buchmeier, M. J., Dutko, F. J., Oldstone, M. B. A. The s rna segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoprotein-1 and glycoprotein-2 Journal of Virology 1985 53:966-968 PMID:3973970 PMCID:PMC254733
- Oldstone, M. B. A., Ahmed, R., Byrne, J., Buchmeier, M. J., Riviere, Y., Southern, P. Virus and immune-responses - lymphocytic choriomeningitis virus as a prototype model of viral pathogenesis British Medical Bulletin 1985 41:70-74 PMID:3882190
- Rodriguez, M., Garrett, R. S., Raitt, M., Lampert, P. W., Oldstone, M. B. A. Virus persists in beta-cells of islets of langerhans and infection is associated with chemical manifestations of diabetes .2. Morphologic observations American Journal of Pathology 1985 121:497-504 PMID:3907367 PMCID:PMC1887922
- Sipe, J. C., Knobler, R. L., Braheny, S. L., Rice, G. P. A., Panitch, H. S., Oldstone, M. B. A. A neurologic rating-scale (nrs) for use in multiple-sclerosis Neurology 1984 34:1368-1372 PMID:6541311
- Southern, P. J., Blount, P., Oldstone, M. B. A. Analysis of persistent virus-infections by insitu hybridization to whole-mouse sections Nature 1984 312:555-558 DOI:10.1038/312555a0 PMID:6504163
- Fujinami, R. S., Norrby, E., Oldstone, M. B. A. Antigenic modulation induced by monoclonal-antibodies - antibodies to measles-virus hemagglutinin alters expression of other viral polypeptides in infected-cells Journal of Immunology 1984 132:2618-2621 PMID:6546943
- Byrne, J. A., Ahmed, R., Oldstone, M. B. A. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants Journal of Immunology 1984 133:433-439 PMID:6202788
- Byrne, J. A., Oldstone, M. B. A. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo Journal of Virology 1984 51:682-686 PMID:6332201 PMCID:PMC255828
- Knobler, R. L., Panitch, H. S., Braheny, S. L., Sipe, J. C., Rice, G. P. A., Huddlestone, J. R., Francis, G. S., Hooper, C. J., Kaminlewis, R. M., Johnson, K. P., Oldstone, M. B. A., Merigan, T. C. Clinical-trial of natural alpha interferon in multiple-sclerosis Annals of the New York Academy of Sciences 1984 436:382-388 DOI:10.1111/j.1749-6632.1984.tb14809.x PMID:6398020
- Rice, G. P. A., Schrier, R. D., Oldstone, M. B. A. Cytomegalovirus infects human-lymphocytes and monocytes - virus expression is restricted to immediate-early gene-products Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 1984 81:6134-6138 DOI:10.1073/pnas.81.19.6134 PMID:6091137
- Rice, G. P. A., Finney, D., Braheny, S. L., Knobler, R. L., Sipe, J. C., Oldstone, M. B. A. Disease-activity markers in multiple-sclerosis - another look at suppressor cells defined by monoclonal antibody-okt4, antibody-okt5, and antibody okt8 Journal of Neuroimmunology 1984 6:75-84 DOI:10.1016/0165-5728(84)90028-6 PMID:6233298
- Knobler, R. L., Tunison, L. A., Oldstone, M. B. A. Host genetic-control of mouse hepatitis-virus type-4 (jhm strain) replication .1. Restriction of virus amplification and spread in macrophages from resistant mice Journal of General Virology 1984 65:1543-1548 DOI:10.1099/0022-1317-65-9-1543 PMID:6088681
- Jacoby, D. R., Olding, L. B., Oldstone, M. B. A. Immunological regulation of fetal maternal balance Advances in Immunology 1984 35:157-208 DOI:10.1016/s0065-2776(08)60576-3 PMID:6235725
- Ahmed, R., Salmi, A., Butler, L. D., Chiller, J. M., Oldstone, M. B. A. Selection of genetic-variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice - role in suppression of cyto-toxic lymphocyte-t response and viral persistence Journal of Experimental Medicine 1984 160:521-540 DOI:10.1084/jem.160.2.521 PMID:6332167
- Knobler, R. L., Panitch, H. S., Braheny, S. L., Sipe, J. C., Rice, G. P. A., Huddlestone, J. R., Francis, G. S., Hooper, C. J., Kaminlewis, R. M., Johnson, K. P., Oldstone, M. B. A., Merigan, T. C. Systemic alpha-interferon therapy of multiple-sclerosis Neurology 1984 34:1273-1279 PMID:6384817
- Rice, G. P. A., Sipe, J. C., Braheny, S. L., Knobler, R. L., Finney, D. A., Oldstone, M. B. A. The failure of monoclonal antibody-defined lymphocyte subsets to monitor disease-activity in patients with multiple-sclerosis Annals of the New York Academy of Sciences 1984 436:271-280 DOI:10.1111/j.1749-6632.1984.tb14799.x PMID:6241819
- Oldstone, M. B. A., Rodriguez, M., Daughaday, W. H., Lampert, P. W. Viral perturbation of endocrine function - disordered cell-function leads to disturbed homeostasis and disease Nature 1984 307:278-281 DOI:10.1038/307278a0 PMID:6694729
- Ahmed, R., Byrne, J. A., Oldstone, M. B. A. Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains Journal of Virology 1984 51:34-41 PMID:6610062 PMCID:PMC254395
- Casali, P., Rice, G. P. A., Oldstone, M. B. A. Viruses disrupt functions of human-lymphocytes - effects of measles-virus and influenza-virus on lymphocyte-mediated killing and antibody-production Journal of Experimental Medicine 1984 159:1322-1337 DOI:10.1084/jem.159.5.1322 PMID:6716049
- Rice, G. P. A., Casali, P., Oldstone, M. B. A. A new solid-phase enzyme-linked immunosorbent-assay for specific antibodies to measles-virus Journal of Infectious Diseases 1983 147:1055-1059 PMID:6343523
- Fujinami, R. S., Oldstone, M. B. A. Antigenic modulation - a mechanism of viral persistence Progress in Brain Research 1983 59:105-111 PMID:6198676
- Jacoby, D. R., Oldstone, M. B. A. Delineation of suppressor and helper activity within the okt4-defined lymphocyte-t subset in human newborns Journal of Immunology 1983 131:1765-1770 PMID:6225798
- Dutko, F. J., Oldstone, M. B. A. Genomic and biological variation among commonly used lymphocytic choriomeningitis virus-strains Journal of General Virology 1983 64:1689-1698 DOI:10.1099/0022-1317-64-8-1689 PMID:6875516
- Casali, P., Oldstone, M. B. A. Immune-complexes in viral-infection Current Topics in Microbiology and Immunology 1983 104:7-48 PMID:6307599
- Dales, S., Fujinami, R. S., Oldstone, M. B. A. Infection with vaccinia favors the selection of hybridomas synthesizing autoantibodies against intermediate filaments, one of them cross-reacting with the virus hemagglutinin Journal of Immunology 1983 131:1546-1553 PMID:6684139
- Oldstone, M. B. A., Fujinami, R. S., Tishon, A., Finney, D., Powell, H. C., Lampert, P. W. Mapping of the major histocompatibility complex and viral-antigens on the plasma-membrane of a measles virus-infected cell Virology 1983 127:426-437 DOI:10.1016/0042-6822(83)90155-1 PMID:6575495
- Fujinami, R. S., Oldstone, M. B. A., Wroblewska, Z., Frankel, M. E., Koprowski, H. Molecular mimicry in virus-infection - crossreaction of measles-virus phosphoprotein or of herpes-simplex virus protein with human intermediate filaments Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 1983 80:2346-2350 DOI:10.1073/pnas.80.8.2346 PMID:6300911
- Rice, G. P. A., Casali, P., Merigan, T. C., Oldstone, M. B. A. Natural-killer cell-activity in patients with multiple-sclerosis given alpha-interferon Annals of Neurology 1983 14:333-338 DOI:10.1002/ana.410140312 PMID:6638954
- Oldstone, M. B. A., Jensen, F., Elder, J., Dixon, F. J., Lampert, P. W. Pathogenesis of the slow disease of the central nervous-system associated with wild mouse virus .3. Role of input virus and mcf recombinants in disease Virology 1983 128:154-165 DOI:10.1016/0042-6822(83)90326-4 PMID:6308890
- Rodriguez, M., Vonwedel, R. J., Garrett, R. S., Lampert, P. W., Oldstone, M. B. A. Pituitary dwarfism in mice persistently infected with lymphocytic choriomeningitis virus Laboratory Investigation 1983 49:48-53 PMID:6865330
- Dales, S., Fujinami, R. S., Oldstone, M. B. A. Serologic relatedness between thy-1.2 and actin revealed by monoclonal-antibody Journal of Immunology 1983 131:1332-1338 PMID:6136544
- Rosenthal, K. L., Oldstone, M. B. A., Hengartner, H., Zinkernagel, R. M. Specificity of in vitro cyto-toxic t-cell clones directed against vesicular stomatitis-virus Journal of Immunology 1983 131:475-478 PMID:6190924
- Rodriguez, M., Buchmeier, M. J., Oldstone, M. B. A., Lampert, P. W. Ultrastructural-localization of viral-antigens in the cns of mice persistently infected with lymphocytic choriomeningitis virus (lcmv) American Journal of Pathology 1983 110:95-100 PMID:6336906 PMCID:PMC1916133
- Oldstone, M. B. A., Tishon, A., Buchmeier, M. J. Virus-induced immune complex disease: genetic control of C1q binding complexes in the circulation of mice persistently infected with lymphocytic choriomeningitis virus Journal of Immunology 1983 130:912-918 PMID:6217255
- Cooper, N. R., Oldstone, M. B. A. Virus-infected cells, igg, and the alternative complement pathway Immunology Today 1983 4:107-108 DOI:10.1016/0167-5699(83)90018-x PMID:25291475
- Knobler, R. L., Haspel, M. V., Duboisdalcq, M., Lampert, P. W., Oldstone, M. B. A. Host and virus factors associated with CNS cellular tropism leading to encephalomyelitis or demyelination induced by the JHM strain of mouse hepatitis virus Advances in Experimental Medicine and Biology 1982 142:341-348 DOI:10.1007/978-1-4757-0456-3_28 PMID:6278890
- Oldstone, M. B. A. Immunopathology of persistent viral infections Hospital Practice 1982 17:61-72
- Abb, J., Deinhardt, F., Zander, H., Tenser, R. B., Rapp, F., Goust, J. M., Fudenberg, H. H., Vilcek, J., Ho, M., Merigan, T. C., Oldstone, M. B. A., Jackson, G. G. Infectious Diseases Society of America. Trials of interferon therapy for multiple sclerosis Journal of Infectious Diseases 1982 146:109-115 PMID:6177805
- Dales, S., Oldstone, M. B. A. Localization at high-resolution of antibody-induced mobilization of vaccinia virus hemagglutinin and the major histocompatibility antigens on the plasma-membrane of infected-cells Journal of Experimental Medicine 1982 156:1435-1447 DOI:10.1084/jem.156.5.1435 PMID:7130903
- Casali, P., Oldstone, M. B. A. Mechanisms of killing of measles virus-infected cells by human-lymphocytes - interferon associated and unassociated cell-mediated cyto-toxicity Cellular Immunology 1982 70:330-344 DOI:10.1016/0008-8749(82)90334-3 PMID:6181900
- Oldstone, M. B. A., Buchmeier, M. J. Restricted expression of viral glycoprotein in cells of persistently infected mice Nature 1982 300:360-362 DOI:10.1038/300360a0 PMID:7144891
- Knobler, R. L., Tunison, L. A., Lampert, P. W., Oldstone, M. B. A. Selected mutants of mouse hepatitis-virus type-4 (jhm-strain) induce different cns diseases - pathobiology of disease induced by wild-type and mutant-ts8 and mutant-ts15 in balb/c and sjl/j mice American Journal of Pathology 1982 109:157-168 PMID:6291396 PMCID:PMC1916093
- Huddlestone, J. R., Oldstone, M. B. A. Suppressor T cells are activated in vivo in patients with multiple sclerosis coinciding with remission from acute attack Journal of Immunology 1982 129:915-917 PMID:6213712
- Sissons, J. G. P., Schreiber, R. D., Cooper, N. R., Oldstone, M. B. A. The role of antibody and complement in lysing virus-infected cells Medical Microbiology and Immunology 1982 170:221-227 DOI:10.1007/bf02123312 PMID:7048046
- Knobler, R. L., Lampert, P. W., Oldstone, M. B. A. Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of mhv-4 Nature 1982 298:279-280 DOI:10.1038/298279a0 PMID:6283382
- Oldstone, M. B. A., Sinha, Y. N., Blount, P., Tishon, A., Rodriguez, M., Vonwedel, R., Lampert, P. W. Virus-induced alterations in homeostasis: alteration in differentiated functions of infected cells in vivo Science 1982 218:1125-1127 DOI:10.1126/science.7146898 PMID:7146898
- Dutko, F. J., Oldstone, M. B. A. Cytomegalovirus causes a latent infection in undifferentiated cells and is activated by induction of cell-differentiation Journal of Experimental Medicine 1981 154:1636-1651 DOI:10.1084/jem.154.5.1636 PMID:6271894
- Fujinami, R. S., Oldstone, M. B. A. Failure to cleave measles-virus fusion protein in lymphoid-cells - a possible mechanism for viral persistence in lymphocytes Journal of Experimental Medicine 1981 154:1489-1499 DOI:10.1084/jem.154.5.1489 PMID:6895382
- Hoffman, P. M., Robbins, D. S., Oldstone, M. B. A., Gibbs, C. J., Gajdusek, D. C. Humoral immunity in guamanians with amyotrophic lateral sclerosis and parkinsonism-dementia Annals of Neurology 1981 10:193-196 DOI:10.1002/ana.410100210 PMID:7283404
- Fujinami, R. S., Sissons, J. G. P., Oldstone, M. B. A. Immune reactive measles virus polypeptides on the cell's surface: turnover and relationship of the glycoproteins to each other and to HLA determinants Journal of Immunology 1981 127:935-940 PMID:6167634
- Casali, P., Sissons, J. G. P., Buchmeier, M. J., Oldstone, M. B. A. In vitro generation of human cytotoxic lymphocytes by virus. Viral glycoproteins induce nonspecific cell-mediated cytotoxicity without release of interferon Journal of Experimental Medicine 1981 154:840-855 DOI:10.1084/jem.154.3.840 PMID:7276828 PMCID:PMC2186447
- Harfast, B., Huddlestone, J. R., Casali, P., Merigan, T. C., Oldstone, M. B. A. Interferon acts directly on human lymphocytes-b to modulate immunoglobulin-synthesis Journal of Immunology 1981 127:2146-2150 PMID:6170691
- Buchmeier, M. J., Lewicki, H. A., Tomori, O., Oldstone, M. B. A. Monoclonal-antibodies to lymphocytic choriomeningitis and pichinde viruses - generation, characterization, and cross-reactivity with other arenaviruses Virology 1981 113:73-85 DOI:10.1016/0042-6822(81)90137-9 PMID:6267791
- Knobler, R. L., Haspel, M. V., Oldstone, M. B. A. Mouse hepatitis-virus type-4 (jhm strain)-induced fatal central nervous-system disease .1. Genetic-control and the murine neuron as the susceptible site of disease Journal of Experimental Medicine 1981 153:832-843 DOI:10.1084/jem.153.4.832 PMID:6265583
- Harfast, B., Huddlestone, J. R., Braheny, S., Seybold, M. E., Oldstone, M. B. A. Myasthenia-gravis - in vitro immunoglobulin production with pokeweed mitogen challenge and lymphocyte-b and lymphocyte-t competence Clinical Immunology and Immunopathology 1981 20:336-345 DOI:10.1016/0090-1229(81)90144-6 PMID:6210478
- Casali, P., Sissons, J. G. P., Fujinami, R. S., Oldstone, M. B. A. Purification of measles-virus glycoproteins and their integration into artificial lipid-membranes Journal of General Virology 1981 54:161-171 DOI:10.1099/0022-1317-54-1-161 PMID:7288404
- Knobler, R. L., Duboisdalcq, M., Haspel, M. V., Claysmith, A. P., Lampert, P. W., Oldstone, M. B. A. Selective localization of wild-type and mutant mouse hepatitis-virus (jhm strain) antigens in cns tissue by fluorescence, light and electron-microscopy Journal of Neuroimmunology 1981 1:81-92 DOI:10.1016/0165-5728(81)90010-2 PMID:6276437
- Fujinami, R. S., Oldstone, M. B. A. Alterations in expression of measles-virus polypeptides by antibody - molecular events in antibody-induced antigenic modulation Journal of Immunology 1980 125:78-85 PMID:7381212
- Sissons, J. G. P., Oldstone, M. B. A., Schreiber, R. D. Antibody-independent activation of the alternative complement pathway by measles virus-infected cells Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences 1980 77:559-562 DOI:10.1073/pnas.77.1.559 PMID:6928644
- Oldstone, M. B. A., Tishon, A., Dutko, F. J., Kennedy, S. I. T., Holland, J. J., Lampert, P. W. Does the major histocompatibility complex serve as a specific receptor for semliki forest virus Journal of Virology 1980 34:256-265 PMID:7373708 PMCID:PMC288691
- Sissons, J. G. P., Oldstone, M. B. A. Killing of virus-infected cells by cyto-toxic lymphocytes Journal of Infectious Diseases 1980 142:114-119 PMID:6249872
- Oldstone, M. B. A., Jensen, F., Dixon, F. J., Lampert, P. W. Pathogenesis of the slow disease of the central nervous-system associated with wild mouse virus .2. Role of virus and host gene-products Virology 1980 107:180-193 DOI:10.1016/0042-6822(80)90283-4 PMID:6255677
- Brautigam, A. R., Oldstone, M. B. A. Replication of murine cytomegalovirus in reproductive tissues American Journal of Pathology 1980 98:213-223 PMID:6243206 PMCID:PMC1903396
- Doyle, L. B., Doyle, M. V., Oldstone, M. B. A. Susceptibility of newborn mice with h-2k backgrounds to lymphocytic choriomeningitis virus-infection Immunology 1980 40:589-596 PMID:6776035 PMCID:PMC1458105
- Oldstone, M. B. A., Buchmeier, M. J., Doyle, M. V., Tishon, A. Virus-induced immune complex disease: specific anti-viral antibody and C1q binding material in the circulation during persistent lymphocytic choriomeningitis virus infection Journal of Immunology 1980 124:831-838 PMID:6444319
- Huddlestone, J. R., Lampert, P. W., Oldstone, M. B. A. Virus-lymphocyte interactions - infection of tg and tm subsets by measles-virus Clinical Immunology and Immunopathology 1980 15:502-509 DOI:10.1016/0090-1229(80)90062-8 PMID:6966202
- Sissons, J. G. P., Cooper, N. R., Oldstone, M. B. A. Alternative complement pathway-mediated lysis of measles-virus infected-cells - induction by igg antibody bound to individual viral glycoproteins and comparative efficacy of f(ab')2 and fab' fragments Journal of Immunology 1979 123:2144-2149 PMID:489977
- Oldstone, M. B. A., Lampert, P. W. Antibody mediated complement dependent lysis of virus-infected cells Springer Seminars in Immunopathology 1979 2:261-283
- Fujinami, R. S., Oldstone, M. B. A. Antiviral antibody reacting on the plasma membrane alters measles virus expression inside the cell Nature 1979 279:529-530 DOI:10.1038/279529a0 PMID:450095
- Huddlestone, J. R., Merigan, T. C., Oldstone, M. B. A. Induction and kinetics of natural killer cells in humans following interferon therapy Nature 1979 282:417-419 DOI:10.1038/282417a0 PMID:503223
- Huddlestone, J. R., Oldstone, M. B. A. Lymphocyte-mediated cytotoxicity to measles-virus in patients with multiple-sclerosis Clinical Immunology and Immunopathology 1979 13:444-451 DOI:10.1016/0090-1229(79)90087-4 PMID:487666
- Sissons, J. G. P., Schreiber, R. D., Perrin, L. H., Cooper, N. R., Mullereberhard, H. J., Oldstone, M. B. A. Lysis of measles virus-infected cells by the purified cytolytic alternative complement pathway and antibody Journal of Experimental Medicine 1979 150:445-454 PMID:479760 PMCID:PMC2185658
- Dutko, F. J., Oldstone, M. B. A. Murine cytomegalo-virus infects spermatogenic cells Proceedings of the National Academy of Sciences of the United States of America 1979 76:2988-2991 DOI:10.1073/pnas.76.6.2988 PMID:223164
- Brautigam, A. R., Dutko, F. J., Olding, L. B., Oldstone, M. B. A. Pathogenesis of murine cytomegalo-virus infection - macrophage as a permissive cell for cytomegalo-virus infection, replication and latency Journal of General Virology 1979 44:349-359 DOI:10.1099/0022-1317-44-2-349 PMID:230287
- Buchmeier, M. J., Oldstone, M. B. A. Protein-structure of lymphocytic choriomeningitis virus - evidence for a cell-associated precursor of the virion glycopeptides Virology 1979 99:111-120 DOI:10.1016/0042-6822(79)90042-4 PMID:494491
- Huddlestone, J. R., Oldstone, M. B. A. T-suppressor lymphocytes-(tg) fluctuate in parallel with changes in the clinical course of patients with multiple-sclerosis Journal of Immunology 1979 123:1615-1618 PMID:314466
- Perrin, L. H., Reynolds, D., Zinkernagel, R., Oldstone, M. B. A. Generation of virus-specific cytolytic activity in human peripheral lymphocytes after vaccination with vaccinia virus and measles-virus Medical Microbiology and Immunology 1978 166:71-79 DOI:10.1007/bf02121136 PMID:723792
- Oldstone, M. B. A., Tishon, A. Immunological injury in measles-virus infection .4. Antigenic modulation and abrogation of lymphocyte lysis of virus-infected cells Clinical Immunology and Immunopathology 1978 9:55-62 DOI:10.1016/0090-1229(78)90120-4 PMID:618410
- Doyle, M. V., Oldstone, M. B. A. Interactions between viruses and lymphocytes. I. In vivo replication of lymphocytic choriomeningitis virus in mononuclear cells during both chronic and acute viral infections Journal of Immunology 1978 121:1262-1269 PMID:308960
- Buchmeier, M. J., Elder, J. H., Oldstone, M. B. A. Protein-structure of lymphocytic choriomeningitis virus - identification of virus structural and cell associated polypeptides Virology 1978 89:133-145 DOI:10.1016/0042-6822(78)90047-8 PMID:685174
- Haspel, M. V., Lampert, P. W., Oldstone, M. B. A. Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination Proceedings of the National Academy of Sciences of the United States of America 1978 75:4033-4036 DOI:10.1073/pnas.75.8.4033 PMID:279022
- Buchmeier, M. J., Oldstone, M. B. A. Virus-induced immune complex disease: identification of specific viral antigens and antibodies deposited in complexes during chronic lymphocytic choriomeningitis virus infection Journal of Immunology 1978 120:1297-1304 PMID:76662
- Oldstone, M. B. A., Tishon, A., Moretta, L. Active thymus derived suppressor lymphocytes in human cord blood Nature 1977 269:333-335 DOI:10.1038/269333a0 PMID:302917
- Oldstone, M. B. A., Holmstoen, J., Welsh, R. M. Alterations of acetylcholine enzymes in neuroblastoma-cells persistently infected with lymphocytic choriomeningitis virus Journal of Cellular Physiology 1977 91:459-472 DOI:10.1002/jcp.1040910316 PMID:193868
- Perrin, L. H., Oldstone, M. B. A. Formation and fate of virus antigen-antibody complexes Journal of Immunology 1977 118:316-322 PMID:830754
- Haspel, M. V., Pellegrino, M. A., Lampert, P. W., Oldstone, M. B. A. Human histocompatibility determinants and virus-antigens - effect of measles-virus infection on hla expression Journal of Experimental Medicine 1977 146:146-156 DOI:10.1084/jem.146.1.146 PMID:68989
- Perrin, L. H., Zinkernagel, R. M., Oldstone, M. B. A. Immune-response in humans after vaccination with vaccinia virus - generation of a virus-specific cytotoxic activity by human peripheral lymphocytes Journal of Experimental Medicine 1977 146:949-969 DOI:10.1084/jem.146.4.949 PMID:302316
- Perrin, L. H., Tishon, A., Oldstone, M. B. A. Immunological injury in measles-virus infection .3. Presence and characterization of human cytotoxic lymphocytes Journal of Immunology 1977 118:282-290 PMID:830751
- Hoffsten, P. E., Oldstone, M. B. A., Dixon, F. J. Immunopathology of adoptive immunization in mice chronically infected with lymphocytic choriomeningitis virus Clinical Immunology and Immunopathology 1977 7:44-52 DOI:10.1016/0090-1229(77)90028-9 PMID:852153
- Welsh, R. M., Oldstone, M. B. A. Inhibition of immunological injury of cultured-cells infected with lymphocytic choriomeningitis virus - role of defective interfering virus in regulating viral antigenic expression Journal of Experimental Medicine 1977 145:1449-1468 DOI:10.1084/jem.145.6.1449 PMID:301173
- Merigan, T. C., Oldstone, M. B. A., Welsh, R. M. Interferon-production during lymphocytic choriomeningitis virus-infection of nude and normal mice Nature 1977 268:67-68 DOI:10.1038/268067a0 PMID:301989
- Oldstone, M. B. A., Lampert, P. W., Lee, S., Dixon, F. J. Pathogenesis of slow disease of central nervous-system associated with wm-1504-e virus American Journal of Pathology 1977 88:193-212 PMID:195470 PMCID:PMC2032160
- Welsh, R. M., Lampert, P. W., Oldstone, M. B. A. Prevention of virus-induced cerebellar disease by defective-interfering lymphocytic choriomeningitis virus Journal of Infectious Diseases 1977 136:391-399 PMID:903677
- Welsh, R. M., Lampert, P. W., Burner, P. A., Oldstone, M. B. A. Antibody-complement interactions with purified lymphocytic choriomeningitis virus Virology 1976 73:59-71 DOI:10.1016/0042-6822(76)90060-x PMID:986722
- Oldstone, M. B. A., Delvillano, B. C., Dixon, F. J. Autologous immune-responses to major oncornavirus polypeptides in unmanipulated akr-j mice Journal of Virology 1976 18:176-181 PMID:176459 PMCID:PMC515536
- Zinkernagel, R. M., Oldstone, M. B. A. Cells that express viral-antigens but lack h-2 determinants are not lysed by immune thymus-derived lymphocytes but are lysed by other antiviral immune attack mechanisms Proceedings of the National Academy of Sciences of the United States of America 1976 73:3666-3670 DOI:10.1073/pnas.73.10.3666 PMID:1086476
- Oldstone, M. B. A., Perrin, L. H., Wilson, C. B., Norris, F. H. Evidence for immune-complex formation in patients with amyotrophic lateral sclerosis Lancet 1976 2:169-172 PMID:73795
- Oldstone, M. B. A., Haspel, M. V., Pellegrino, M. A., Kingsbury, D. T., Olding, L. Histocompatibility complex and virus infection latency and activation Transplantation Reviews 1976 31:225-239 PMID:785728
- Welsh, R. M., Jensen, F. C., Cooper, N. R., Oldstone, M. B. A. Inactivation and lysis of oncornaviruses by human-serum Virology 1976 74:432-440 DOI:10.1016/0042-6822(76)90349-4 PMID:62448
- Holland, J. J., Villarreal, L. P., Welsh, R. M., Oldstone, M. B. A., Kohne, D., Lazzarini, R., Scolnick, E. Long-term persistent vesicular stomatitis-virus and rabies virus-infection of cells in vitro Journal of General Virology 1976 33:193-211 DOI:10.1099/0022-1317-33-2-193 PMID:186559
- Cooper, N. R., Jensen, F. C., Welsh, R. M., Oldstone, M. B. A. Lysis of rna tumor-viruses by human-serum - direct antibody-independent triggering of classical complement pathway Journal of Experimental Medicine 1976 144:970-984 DOI:10.1084/jem.144.4.970 PMID:62019
- Joseph, B. S., Perrin, L. H., Oldstone, M. B. A. Measurement of virus antigens on surfaces of hela-cells persistently infected with wild-type and vaccine strains of measles-virus by radioimmune assay Journal of General Virology 1976 30:329-337 DOI:10.1099/0022-1317-30-3-329 PMID:1255135
- Perrin, L. H., Joseph, B. S., Cooper, N. R., Oldstone, M. B. A. Mechanism of injury of virus-infected cells by antiviral antibody and complement - participation of igg, f(ab')2, and alternative complement pathway Journal of Experimental Medicine 1976 143:1027-1041 DOI:10.1084/jem.143.5.1027 PMID:177712
- Olding, L. B., Kingsbury, D. T., Oldstone, M. B. A. Pathogenesis of cytomegalovirus infection. Distribution of viral products, immune complexes and autoimmunity during latent murine infection Journal of General Virology 1976 33:267-280 DOI:10.1099/0022-1317-33-2-267 PMID:186563
- Jondai, M., Klein, G., Oldstone, M. B. A., Bokish, V., Yefenof, E. Surface markers on human b and t lymphocytes .8. Association between complement and epstein-barr virus receptors on human lymphoid-cells Scandinavian Journal of Immunology 1976 5:401-410 DOI:10.1111/j.1365-3083.1976.tb00294.x PMID:59946
- Yefenof, E., Klein, G., Jondal, M., Oldstone, M. B. A. Surface markers on human b-lymphocytes and t-lymphocytes .9. 2-color immunofluorescence studies on association between ebv receptors and complement receptors on surface of lymphoid-cell lines International Journal of Cancer 1976 17:693-700 DOI:10.1002/ijc.2910170602 PMID:181330
- Olding, L. B., Oldstone, M. B. A. Thymus-derived peripheral lymphocytes from human newborns inhibit division of their mothers' lymphocytes Journal of Immunology 1976 116:682-686 PMID:1082891
- Lampert, P. W., Joseph, B. S., Oldstone, M. B. A. Antibody-induced capping of measles-virus antigens on plasma-membrane studied by electron-microscopy Journal of Virology 1975 15:1248-1255 PMID:49437 PMCID:PMC354580
- Welsh, R. M., Burner, P. A., Holland, J. J., Oldstone, M. B. A., Thompson, H. A., Villarreal, L. P. Comparison of biochemical and biological properties of standard and defective lymphocytic choriomeningitis virus Bulletin of the World Health Organization 1975 52:403-408 PMID:60182 PMCID:PMC2366663
- Welsh, R. M., Cooper, N. R., Jensen, F. C., Oldstone, M. B. A. Human-serum lyses rna tumor-viruses Nature 1975 257:612-614 DOI:10.1038/257612a0 PMID:170540
- Oldstone, M. B. A. Immune-complexes in cancer - demonstration of complexes in mice bearing neuroblastomas Journal of the National Cancer Institute 1975 54:223-228 PMID:1089793
- Joseph, B. S., Oldstone, M. B. A. Immunological injury in measles-virus infection .2. Suppression of immune injury through antigenic modulation Journal of Experimental Medicine 1975 142:864-876 DOI:10.1084/jem.142.4.864 PMID:1176889
- Joseph, B. S., Cooper, N. R., Oldstone, M. B. A. Immunological injury of cultured-cells infected with measles-virus Journal of Experimental Medicine 1975 141:761-774 PMID:1092789 PMCID:PMC2189741
- Olding, L. B., Jensen, F. C., Oldstone, M. B. A. Pathogenesis of cytomegalovirus-infection .1. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction Journal of Experimental Medicine 1975 141:561-572 DOI:10.1084/jem.141.3.561 PMID:163887
- Oldstone, M. B. A., Welsh, R. M., Joseph, B. S. Pathogenic mechanisms of tissue injury in persistent viral-infections Annals of the New York Academy of Sciences 1975 256:65-72 DOI:10.1111/j.1749-6632.1975.tb36035.x PMID:169724
- Oldstone, M. B. A. Relationship between major histocompatibility antigens and disease - possible associations with human arenavirus diseases Bulletin of the World Health Organization 1975 52:479-486 PMID:60183 PMCID:PMC2366647
- Joseph, B. S., Lampert, P. W., Oldstone, M. B. A. Replication and persistence of measles-virus in defined subpopulations of human leukocytes Journal of Virology 1975 16:1638-1649 PMID:1081602 PMCID:PMC355773
- Oldstone, M. B. A., Bokisch, V. A., Dixon, F. J., Barbosa, L. H., Fuccillo, D., Sever, J. L. Subacute sclerosing panencephalitis - destruction of human brain-cells by antibody and complement in an autologous system Clinical Immunology and Immunopathology 1975 4:52-58 DOI:10.1016/0090-1229(75)90039-2 PMID:1092498
- Norris, F. H., Aguilar, M. J., Colton, R. P., Oldstone, M. B. A., Cremer, N. E. Tubular particles in a case of recurrent lymphocytic meningitis followed by amyotrophic lateral sclerosis Journal of Neuropathology and Experimental Neurology 1975 34:133-147 DOI:10.1097/00005072-197503000-00002 PMID:1123648
- Oldstone, M. B. A. Virus neutralization and virus-induced immune-complex disease - virus-antibody union resulting in immunoprotection or immunological injury - 2 sides of same coin Progress in Medical Virology 1975 19:84-119 PMID:164055
- Oldstone, M. B., Dixon, F. J. Aging and chronic virus-infection - is there a relationship Federation Proceedings 1974 33:2057-2059 PMID:4420504
- Joseph, B. S., Oldstone, M. B. Antibody-induced redistribution of measles-virus antigens on cell-surface Journal of Immunology 1974 113:1205-1209 PMID:4606230
- Oldstone, M. B., Tishon, A., Chiller, J. M. Chronic virus-infection and immune responsiveness .2. Lactic-dehydrogenase virus-infection and immune-response to non-viral antigens Journal of Immunology 1974 112:370-375 PMID:4590825
- Hollis, V. W., Aoki, T., Barrera, O., Oldstone, M. B., Dixon, F. J. Detection of naturally occurring antibodies to rna-dependent DNA-polymerase of murine leukemia-virus in kidney eluates of akr mice Journal of Virology 1974 13:448-454 PMID:4129792 PMCID:PMC355315
- Joseph, B. S., Oldstone, M. B. Expression of selected antigens on surface of cultured neural cells Brain Research 1974 80:421-434 DOI:10.1016/0006-8993(74)91027-0 PMID:4138443
- Cooper, N. R., Polley, M. J., Oldstone, M. B. Failure of terminal complement components to induce lysis of moloney virus transformed lymphocytes Journal of Immunology 1974 112:866-868 PMID:4855965
- Oldstone, M. B., Cooper, N. R., Larson, D. L. Formation and biologic role of polyoma virus-antibody complexes - critical role for complement Journal of Experimental Medicine 1974 140:549-565 DOI:10.1084/jem.140.2.549 PMID:4367757
- McDevitt, H. O., Oldstone, M. B., Pincus, T. Histocompatibility-linked genetic-control of specific immune-responses to viral-infection Transplantation Reviews 1974 19:209-225 PMID:4135405
- Oldstone, M. B. A., Theofilopoulos, A. N., Gunven, P., Klein, G. Immune-complexes associated with neoplasia - presence of epstein-barr virus antigen-antibody complexes in burkitts-lymphoma Intervirology 1974 4:292-302 PMID:4377147
- Olding, L. B., Benirschke, K., Oldstone, M. B. Inhibition of mitosis of lymphocytes from human adults by lymphocytes from human newborns Clinical Immunology and Immunopathology 1974 3:79-89 DOI:10.1016/0090-1229(74)90025-7 PMID:4279793
- Olding, L. B., Oldstone, M. B. Lymphocytes from human newborns abrogate mitosis of their mother's lymphocytes Nature 1974 249:161-162 DOI:10.1038/249161a0 PMID:4275485
- Lampert, P. W., Oldstone, M. B. Pathology of choroid-plexus in spontaneous immune-complex disease and chronic viral-infections Virchows Archiv. Abteilung A, Pathologische Anatomie 1974 363:21-32 DOI:10.1007/bf00432202
- Oldstone, M. B., Dixon, F. J. Change in susceptibility of c3h-hej mice to lcm virus-infection Journal of Immunology 1973 111:1613-1615 PMID:4583080
- Oldstone, M. B., Tishon, A., Chiller, J. M., Weigle, W. O., Dixon, F. J. Effect of chronic viral-infection on immune system .1. Comparison of immune responsiveness of mice chronically infected with lcm virus with that of noninfected mice Journal of Immunology 1973 110:1268-1278 PMID:4121421
- Oldstone, M. B., Dixon, F. J., Mitchell, G. F., McDevitt, H. O. Histocompatibility-linked genetic-control of disease susceptibility - murine lymphocytic choriomeningitis virus-infection Journal of Experimental Medicine 1973 137:1201-1212 DOI:10.1084/jem.137.5.1201 PMID:4702099
- Lampert, P. W., Oldstone, M. B. Host immunoglobulin-g and complement deposits in choroid-plexus during spontaneous immune complex disease Science 1973 180:408-410 DOI:10.1126/science.180.4084.408 PMID:4267048
- Oldstone, M. B., Yamazaki, S., Niwa, A., Notkins, A. L. In vitro detection of cells infected with lactic dehydrogenase virus (LDV) by fluorescein-labeled antibody to LDV Intervirology 1973 2:261-265 DOI:10.1159/000149431 PMID:4604591
- Oldstone, M. B., Dixon, F. J. Disease accompanying in utero viral infection. The role of maternal antibody in tissue injury after transplacental infection with lymphocytic choriomeningitis virus Journal of Experimental Medicine 1972 135:827-838 DOI:10.1084/jem.135.4.827 PMID:4259667 PMCID:PMC2139158
- Oldstone, M. B., Dixon, F. J. Inhibition of antibodies to nuclear antigen and to DNA in new zealand mice infected with lactate dehydrogenase virus Science 1972 175:784-786 DOI:10.1126/science.175.4023.784 PMID:4536694
- Oldstone, M. B., Aoki, T., Dixon, F. J. The antibody response of mice to murine leukemia virus in spontaneous infection: Absence of classical immunologic tolerance (akr mice-complement-fixing antibodies-lymphocytic choriomeningitis virus-immunofluorescence-glomerular deposits of antigen-antibody complexes) Proceedings of the National Academy of Sciences of the United States of America 1972 69:134-138 DOI:10.1073/pnas.69.1.134 PMID:4550501 PMCID:PMC427561
- Oldstone, M. B., Aoki, T., Dixon, F. J. Activation of spontaneous murine leukemia virus-related antigen by lymphocytic choriomeningitis virus Science 1971 174:843-845 DOI:10.1126/science.174.4011.843 PMID:4330471
- Oldstone, M. B., Dixon, F. J. Acute viral infection: Tissue injury mediated by anti-viral antibody through a complement effector system Journal of Immunology 1971 107:1274-1280 PMID:5000724
- Oldstone, M. B. Autoimmunity and viruses--fact or fiction: Persistent lcm viral infection, anti-lcm viral immune response, and tissue injury American Journal of Clinical Pathology 1971 56:299-302 PMID:5094495
- Lerner, R. A., Oldstone, M. B., Cooper, N. R. Cell cycle-dependent immune lysis of moloney virus-transformed lymphocytes: Presence of viral antigen, accessibility to antibody, and complement activation Proceedings of the National Academy of Sciences of the United States of America 1971 68:2584-2588 DOI:10.1073/pnas.68.10.2584 PMID:4944633 PMCID:PMC389473
- Oldstone, M. B., Dixon, F. J. Immune complex disease in chronic viral infections Journal of Experimental Medicine 1971 134:32-40 PMID:19867377 PMCID:PMC2139060
- Oldstone, M. B., Dixon, F. J. Lactic dehydrogenase virus-induced immune complex type of glomerulonephritis Journal of Immunology 1971 106:1260-1263 PMID:4102403
- Dixon, F. J., Oldstone, M. B., Tonietti, G. Pathogenesis of immune complex glomerulonephritis of new zealand mice Journal of Experimental Medicine 1971 134:65-71 PMID:19867382 PMCID:PMC2139082
- Oldstone, M. B., Dixon, F. J. Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. Ii. Relationship of the anti-lymphocytic choriomeningitis immune response to tissue injury in chronic lymphocytic choriomeningitis disease Journal of Experimental Medicine 1970 131:1-19 DOI:10.1084/jem.131.1.1 PMID:5460613 PMCID:PMC2138769
- Oldstone, M. B., Dixon, F. J. Persistent lymphocytic choriomeningitis viral infection. 3. Virus-anti-viral antibody complexes and associated chronic disease following transplacental infection Journal of Immunology 1970 105:829-837 PMID:4990436
- Tonietti, G., Oldstone, M. B., Dixon, F. J. The effect of induced chronic viral infections on the immunologic diseases of new zealand mice Journal of Experimental Medicine 1970 132:89-109 DOI:10.1084/jem.132.1.89 PMID:4323748 PMCID:PMC2138747
- Oldstone, M. B., Dixon, F. J. Tissue injury in lymphocytic choriomeningitis viral infection: Virus-induced immunologically specific release of a cytotoxic factor from immune lymphoid cells Virology 1970 42:805-813 DOI:10.1016/0042-6822(70)90330-2 PMID:4992354
- Sutton, G. G., Oldstone, M. B. Evidence against pyridoxine deficiency as mechanism of penicillin seizures Neurology 1969 19:859-864 PMID:5816879
- Oldstone, M. B., Dixon, F. J. Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice Journal of Experimental Medicine 1969 129:483-505 DOI:10.1084/jem.129.3.483 PMID:4179834 PMCID:PMC2138618
- Dixon, F. J., Oldstone, M. B., Tonietti, G. Virus-induced immune-complex-type glomerulonephritis Transplantation Proceedings 1969 1:945-948 PMID:4939689
- Oldstone, M. B., Dixon, F. J. Direct immunofluorescent tissue culture assay for lymphocytic choriomeningitis virus Journal of Immunology 1968 100:1135-1138 PMID:4967592
- Oldstone, M. B., Dixon, F. J. Immunohistochemical study of allergic encephalomyelitis American Journal of Pathology 1968 52:251-263 PMID:4169739 PMCID:PMC2013335
- Oldstone, M. B., Dixon, F. J. Susceptibility of different mouse strains to lymphocytic choriomeningitis virus Journal of Immunology 1968 100:355-357 PMID:4966455
- Oldstone, M. B., Dixon, F. J. Lymphocytic choriomeningitis: Production of antibody by "tolerant" infected mice Science 1967 158:1193-1195 DOI:10.1126/science.158.3805.1193 PMID:4862090
- Oldstone, M. B. Hospital-acquired staphylococcal infection. Role of airborne organisms. 9-Month review of all admissions and surgical procedures American Surgeon 1966 32:391-394 PMID:5929671
- Oldstone, M. B., Nelson, E. Central nervous system manifestations of penicillin toxicity in man Neurology 1966 16:693-700 DOI:10.1212/WNL.16.7.693 PMID:5949436
- Oldstone, M. B. Disturbance of pituitary-adrenal interrelationships in benign intracranial hypertension (pseudotumor cerebri) Journal of Clinical Endocrinology & Metabolism 1966 26:1366-1369 DOI:10.1210/jcem-26-12-1366 PMID:4289594
- Oldstone, M. B. The endocrinological aspects of benign intracranial hypertension Archives of Neurology 1966 15:362-366 DOI:10.1001/archneur.1966.00470160028004 PMID:4287942
- Wood, W. H., Oldstone, M., Schultz, R. B. A re-evaluation of blood culture as an autopsy procedure American Journal of Clinical Pathology 1965 43:241-247 PMID:14270966
- Israel, J., Oldstone, M., Levenson, S., Frank, E. D., Fine, J. Mechanism of action of staphylococcal toxin in rabbits Proceedings of the Society for Experimental Biology and Medicine 1961 108:709-711 DOI:10.3181/00379727-108-27043
- Wisseman, C. L., Oldstone, M. B., Pazourek, L., Boccuti, A., James, H. Studies on rickettsial toxins. V. Dissimilarity between action of rickettsial mouse lethal toxin and bacterial endotoxin in mice Journal of Immunology 1961 86:613-617 PMID:13786026
- Oldstone, M. B. A. Altered reactivity to Escherichia coli endotoxin of mice subjected to sub-lethal tourniquet treatment Proceedings of the Society for Experimental Biology and Medicine 1959 102:256-258 DOI:10.3181/00379727-102-25211 PMID:14428624
chapter
- Oldstone, M. B. A. An odyssey to viral pathogenesis Annual Review of Pathology: Mechanisms of Disease, Vol 11. 1-19. 2016 DOI:10.1146/annurev-pathol-012615-044107
- Rall, G. F., Oldstone, M. B. A. Virus-neuron-cytotoxic T lymphocyte interactions HIV and Dementia. 261-273. 1995

editor of

chapter
- Chemical and genetic tools to explore S1P biology Sphingosine-1-phosphate signaling in immunology and infectious diseases. 55-83. 2014
edited book
- Oldstone, M. B. A., Rosen, H., eds. Sphingosine-1-phosphate signaling in immunology and infectious diseases Current Topics in Microbiology and Immunology. 2014

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