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Oldstone, Michael
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Oldstone, Michael

Faculty Member
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Positions

  • 2017 - Professor, Immunology and Microbiology , Scripps Research
  • 2007 - Resident Scholar (Professor), The University of Alabama (Tuscaloosa) , The University of Alabama System
  • 1997 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 1989 - Head, Viral-Immunobiology Laboratory, Scripps Research
  • 1987 - Head: Pathogenesis (Virology) Affinity Group, Scripps Research
  • 1978 - Adjunct Professor, Department of Neurosciences, School of Medicine, University of California, San Diego
  • 1977 - Member, Department of Immunology, Scripps Clinic and Research Foundation
  • 2008 - 2017 Professor, Immunology and Microbial Science (IMS) , Scripps Research
  • 2004 - 2017 Adjunct Professor of Virology, Department of Infectology, Scripps Florida , Scripps Research
  • 1989 - 2008 Professor, Molecular and Integrative Neurosciences (MIND) , Scripps Research
  • 1972 - 1976 Associate Member, Department of Immunopathology, Scripps Clinic and Research Foundation
  • 1969 - 1971 Assistant Member, Department of Experimental Pathology,, Scripps Clinic and Research Foundation
Dr. Michael Oldstone studies the interaction of viruses and the immune system, how viruses persist and the resultant disease, how a non-lytic virus alters the differentiation function of the infected cell, investigates infectious protein folding disease and uses transgenic mouse models to understand human diseases. Included are molecular explorations for how viruses suppress the immune system or on the other side of the coin, induce autoimmunity.

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  • Michael B.A. Oldstone, M.D.
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Publications

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    • Sullivan, B. M., Sakabe, S., Hartnett, J. N., Ngo, N., Goba, A., Momoh, M., Sandi, J. D., Kanneh, L., Cubitt, B., Garcia, S. D., Ware, B. C., Kotliar, D., et al. High crossreactivity of human T cell responses between Lassa virus lineages PLoS Pathogens  2020 16  DOI:10.1371/journal.ppat.1008352; 10.1371/journal.ppat.1008352.r001; 10.1371/journal.ppat.1008352.r002; 10.1371/journal.ppat.1008352.r003; 10.1371/journal.ppat.1008352.r004  PMID:32142546  PMCID:PMC7080273
    • Marro, B. S., Zak, J., Zavareh, R. B., Teijaro, J. R., Lairson, L. L., Oldstone, M. B. A. Discovery of small molecules for the reversal of T cell exhaustion Cell Reports  2019 29:3293-3302  DOI:10.1016/j.celrep.2019.10.119  PMID:31801090  PMCID:PMC6931400
    • Ware, B. C., Sullivan, B. M., LaVergne, S., Marro, B. S., Egashira, T., Campbell, K. P., Elder, J., Oldstone, M. B. A. A unique variant of lymphocytic choriomeningitis virus that induces pheromone binding protein MUP: Critical role for CTL Proceedings of the National Academy of Sciences of the United States of America  2019 116:18001-18008  DOI:10.1073/pnas.1907070116  PMID:31427525  PMCID:PMC6731760
    • Marro, B. S., Legrain, S., Ware, B. C., Oldstone, M. B. A. Macrophage IFN-I signaling promotes autoreactive T cell infiltration into islets in type 1 diabetes model JCI Insight  2019 4  DOI:10.1172/jci.insight.125067  PMID:30674713
    • Gonzalez-Quintial, R., Nguyen, A., Kono, D. H., Oldstone, M. B. A., Theofilopoulos, A. N., Baccala, R. Lupus acceleration by a MAVS-activating RNA virus requires endosomal TLR signaling and host genetic predisposition PLoS One  2018 13  DOI:10.1371/journal.pone.0203118  PMID:30199535  PMCID:PMC6130858
    • Oldstone, M. B. A., Ware, B. C., Horton, L. E., Welch, M. J., Aiolfi, R., Zarpellon, A., Ruggeri, Z. M., Sullivan, B. M. Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics Proceedings of the National Academy of Sciences of the United States of America  2018 115:E7814-E7823  DOI:10.1073/pnas.1804674115  PMID:30061383  PMCID:PMC6099862
    • Sakabe, S., Sullivan, B. M., Hartnett, J. N., Robles-Sikisaka, R., Gangavarapu, K., Cubitt, B., Ware, B. C., Kotliar, D., Branco, L. M., Goba, A., Momoh, M., Sandi, J. D., et al. Analysis of CD8(+) T cell response during the 2013-2016 Ebola epidemic in West Africa Proceedings of the National Academy of Sciences of the United States of America  2018 115:E7578-E7586  DOI:10.1073/pnas.1806200115  PMID:30038008  PMCID:PMC6094108
    • Smelkinson, M. G., Guichard, A., Teijaro, J. R., Malur, M., Loureiro, M. E., Jain, P., Ganesan, S., Zuniga, E. I., Krug, R. M., Oldstone, M. B., Bier, E. Influenza NS1 directly modulates Hedgehog signaling during infection PLoS Pathogens  2017 13  DOI:10.1371/journal.ppat.1006588  PMID:28837667
    • Marro, B. S., Ware, B. C., Zak, J., de la Torre, J. C., Rosen, H., Oldstone, M. B. A. Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling Proceedings of the National Academy of Sciences of the United States of America  2017 114:3708-3713  DOI:10.1073/pnas.1700878114  PMID:28325871  PMCID:PMC5389329
    • Goba, A., Khan, S. H., Fonnie, M., Fullah, M., Moigboi, A., Kovoma, A., Sinnah, V., Yoko, N., Rogers, H., Safai, S., Momoh, M., Koroma, V., et al. An outbreak of Ebola virus disease in the Lassa fever zone Journal of Infectious Diseases  2016 214:S110-S121  DOI:10.1093/infdis/jiw239  PMID:27402779  PMCID:PMC5050470
    • Hastie, K. M., Igonet, S., Sullivan, B. M., Legrand, P., Zandonatti, M. A., Robinson, J. E., Garry, R. F., Rey, F. A., Oldstone, M. B., Saphire, E. O. Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus LCMV Nature Structural & Molecular Biology  2016 23:513-521  DOI:10.1038/nsmb.3210  PMID:27111888  PMCID:PMC4945123
    • Oldstone, M. B. A. The Anatomy of a Career in Science DNA and Cell Biology  2016 35:109-117  PMID:26836569
    • Teijaro, J. R., Studer, S., Leaf, N., Kiosses, W. B., Nguyen, N., Matsuki, K., Negishi, H., Taniguchi, T., Oldstone, M. B. A., Rosen, H. S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-alpha autoamplification Proceedings of the National Academy of Sciences of the United States of America  2016 113:1351-1356  DOI:10.1073/pnas.1525356113  PMID:26787880  PMCID:PMC4747766
    • Ng, C. T., Mendoza, J. L., Garcia, K. C. Alpha and beta type 1 interferon signaling: passage for diverse biologic outcomes Cell  2016 164:349-352  DOI:10.1016/j.cell.2015.12.027  PMID:26824652  PMCID:PMC4733246
    • Siggs, O. M., Popkin, D. L., Krebs, P., Li, X., Tang, M., Zhan, X., Zeng, M., Lin, P., Xia, Y., Oldstone, M. B. A., Cornall, R. J., Beutler, B. Mutation of the ER retention receptor KDELR1 leads to cell-intrinsic lymphopenia and a failure to control chronic viral infection Proceedings of the National Academy of Sciences of the United States of America  2015 112:E5706-E5714  DOI:10.1073/pnas.1515619112  PMID:26438836  PMCID:PMC4620900
    • Oldstone, M. B. A. A Jekyll and Hyde profile: Type 1 interferon signaling plays a prominent role in the initiation and maintenance of a persistent virus infection Journal of Infectious Diseases  2015 212:S31-S36  DOI:10.1093/infdis/jiu501  PMID:26116728  PMCID:PMC4574552
    • Ng, C. T., Sullivan, B. M., Teijaro, J. R., Lee, A. M., Welch, M., Rice, S., Sheehan, K. C. F., Schreiber, R. D., Oldstone, M. B. A. Blockade of interferon Beta, but not interferon alpha, signaling controls persistent viral infection Cell Host & Microbe  2015 17:653-661  DOI:10.1016/j.chom.2015.04.005  PMID:25974304  PMCID:PMC4432251
    • Sullivan, B. M., Teijaro, J. R., de la Torre, J. C., Oldstone, M. B. A. Early virus-host interactions dictate the course of a persistent infection PLoS Pathogens  2015 11  DOI:10.1371/journal.ppat.1004588  PMID:25569216  PMCID:PMC4287607
    • Baccala, R., Welch, M. J., Gonzalez-Quintial, R., Walsh, K. B., Teijaro, J. R., Nguyen, A., Ng, C. T., Sullivan, B. M., Zarpellon, A., Ruggeri, Z. M., de la Torre, J. C., Theofilopoulos, A. N., et al. Type I interferon is a therapeutic target for virus-induced lethal vascular damage Proceedings of the National Academy of Sciences of the United States of America  2014 111:8925-8930  DOI:10.1073/pnas.1408148111  PMID:24889626  PMCID:PMC4066519
    • Walsh, K. B., Teijaro, J. R., Brock, L. G., Fremgen, D. M., Collins, P. L., Rosen, H., Oldstone, M. B. A. Animal model of respiratory syncytial virus: CD8(+) T cells cause a cytokine storm that is chemically tractable by sphingosine-1-phosphate 1 receptor agonist therapy Journal of Virology  2014 88:6281-6293  DOI:10.1128/jvi.00464-14  PMID:24672024
    • Teijaro, J. R., Walsh, K. B., Rice, S., Rosen, H., Oldstone, M. B. A. Mapping the innate signaling cascade essential for cytokine storm during influenza virus infection Proceedings of the National Academy of Sciences of the United States of America  2014 111:3799-3804  DOI:10.1073/pnas.1400593111  PMID:24572573  PMCID:PMC3956176
    • Teijaro, J. R., Walsh, K. B., Long, J. P., Tordoff, K. P., Stark, G. V., Eisfeld, A. J., Kawaoka, Y., Rosen, H., Oldstone, M. B. A. Protection of ferrets from pulmonary injury due to H1N1 2009 influenza virus infection: immunopathology tractable by sphingosine-1-phosphate 1 receptor agonist therapy Virology  2014 452:152-157  DOI:10.1016/j.virol.2014.01.003  PMID:24606692  PMCID:PMC3954990
    • Oldstone, M. B. A., Rosen, H. Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule Current Topics in Microbiology and Immunology  2014 378:129-147  DOI:10.1007/978-3-319-05879-5_6  PMID:24728596
    • Ng, C. T., Oldstone, M. B. A. IL-10: achieving balance during persistent viral infection Current Topics in Microbiology and Immunology  2014 380:129-144  DOI:10.1007/978-3-662-43492-5_6  PMID:25004816
    • Walsh, K. B., Sidney, J., Welch, M., Fremgen, D. M., Sette, A., Oldstone, M. B. A. CD8(+) T-Cell Epitope Mapping for Pneumonia Virus of Mice in H-2(b) Mice Journal of Virology  2013 87:9949-9952  DOI:10.1128/jvi.00339-13  PMID:23824814  PMCID:PMC3754129
    • Priola, S. A., Ward, A. E., McCall, S. A., Trifilo, M., Choi, Y. P., Solforosi, L., Williamson, R. A., Cruite, J. T., Oldstone, M. B. A. Lack of prion infectivity in fixed heart tissue from patients with Creutzfeldt-Jakob disease or amyloid heart disease Journal of Virology  2013 87:9501-9510  DOI:10.1128/jvi.00692-13  PMID:23785217  PMCID:PMC3754135
    • Kang, S. G., Liu, W. H., Lu, P., Jin, H. Y., Lim, H. W., Shepherd, J., Fremgen, D., Verdin, E., Oldstone, M. B. A., Qi, H., Teijaro, J. R., Xiao, C. MicroRNAs of the miR-17 similar to 92 family are critical regulators of T-FH differentiation Nature Immunology  2013 14:849-857  DOI:10.1038/ni.2648  PMID:23812097  PMCID:PMC3740954
    • Lee, A. M., Cruite, J., Welch, M. J., Sullivan, B., Oldstone, M. B. A. Pathogenesis of Lassa fever virus infection: I. Susceptibility of mice to recombinant Lassa Gp/LCMV chimeric virus Virology  2013 442:114-121  DOI:10.1016/j.virol.2013.04.010  PMID:23684417  PMCID:PMC3686847
    • Ng, C. T., Snell, L. M., Brooks, D. G., Oldstone, M. B. A. Networking at the level of host immunity: immune cell interactions during persistent viral infections Cell Host & Microbe  2013 13:652-664  DOI:10.1016/j.chom.2013.05.014  PMID:23768490  PMCID:PMC3713852
    • Chabot, S., Fakhfakh, A., Beland, K., Lamarre, A., Oldstone, M. B. A., Alvarez, F., Djilali-Saiah, I. Mouse liver-specific CD8(+) T-cells encounter their cognate antigen and acquire capacity to destroy target hepatocytes Journal of Autoimmunity  2013 42:19-28  DOI:10.1016/j.jaut.2012.10.002  PMID:23137675  PMCID:PMC4465814
    • Teijaro, J. R., Ng, C., Lee, A. M., Sullivan, B. M., Sheehan, K. C. F., Welch, M., Schreiber, R. D., de la Torre, J. C., Oldstone, M. B. A. Persistent LCMV infection is controlled by blockade of type I interferon signaling Science  2013 340:207-211  DOI:10.1126/science.1235214  PMID:23580529  PMCID:PMC3640797
    • Bett, C., Kurt, T. D., Lucero, M., Trejo, M., Rozemuller, A. J., Kong, Q. Z., Nilsson, K. P. R., Masliah, E., Oldstone, M. B., Sigurdson, C. J. Defining the conformational features of anchorless, poorly neuroinvasive prions PLoS Pathogens  2013 9:e1003280  DOI:10.1371/journal.ppat.1003280  PMID:23637596  PMCID:PMC3630170
    • Sullivan, B. M., Welch, M. J., Lemke, G., Oldstone, M. B. A. Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus? Journal of Virology  2013 87:4071-4074  DOI:10.1128/jvi.03268-12  PMID:23325690  PMCID:PMC3624193
    • Matheu, M. P., Teijaro, J. R., Walsh, K. B., Greenberg, M. L., Marsolais, D., Parker, I., Rosen, H., Oldstone, M. B. A., Cahalan, M. D. Three phases of CD8 T cell response in the lung following H1N1 influenza infection and sphingosine 1 phosphate agonist therapy PLoS One  2013 8:e58033  DOI:10.1371/journal.pone.0058033  PMID:23533579  PMCID:PMC3606384
    • Oldstone, M. B. A. Lessons learned and concepts formed from study of the pathogenesis of the two negative-strand viruses lymphocytic choriomeningitis and influenza Proceedings of the National Academy of Sciences of the United States of America  2013 110:42-45  DOI:10.1073/pnas.1222025110  PMID:23341590  PMCID:PMC3600446
    • Burri, D. J., Pasquato, A., da Palma, J. R., Igonet, S., Oldstone, M. B. A., Kunz, S. The role of proteolytic processing and the stable signal peptide in expression of the old world arenavirus envelope glycoprotein ectodomain Virology  2013 436:127-133  DOI:10.1016/j.virol.2012.10.038  PMID:23218200  PMCID:PMC3545064
    • Oldstone, M. B. A., Teijaro, J. R., Walsh, K. B., Rosen, H. Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection Virology  2013 435:92-101  DOI:10.1016/j.virol.2012.09.039  PMID:23217619  PMCID:PMC3523270
    • Rosen, H., Stevens, R. C., Hanson, M., Roberts, E., Oldstone, M. B. A. Sphingosine-1-phosphate and its receptors: Structure, signaling, and influence Annual Review of Biochemistry  2013 82:637-662  DOI:10.1146/annurev-biochem-062411-130916  PMID:23527695
    • Oldstone, M. B. A., Edelmann, K. H., McGavern, D. B., Cruite, J. T., Welch, M. J. Molecular anatomy and number of antigen specific CD8 T cells required to cause type 1 diabetes PLoS Pathogens  2012 8:e1003044  DOI:10.1371/journal.ppat.1003044  PMID:23209415  PMCID:PMC3510245
    • Ng, C. T., Oldstone, M. B. A. Infected cd8 alpha(-) dendritic cells are the predominant source of il-10 during establishment of persistent viral infection Proceedings of the National Academy of Sciences of the United States of America  2012 109:14116-14121  DOI:10.1073/pnas.1211910109  PMID:22893686  PMCID:PMC3435180
    • Siggs, O. M., Cruite, J. T., Du, X., Rutschmann, S., Masliah, E., Beutler, B., Oldstone, M. B. A. Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease Proceedings of the National Academy of Sciences of the United States of America  2012 109:13733-13738  DOI:10.1073/pnas.1211499109  PMID:22869751  PMCID:PMC3427069
    • Welch, M. J., Teijaro, J. R., Lewicki, H. A., Colonna, M., Oldstone, M. B. A. CD8 T cell defect of TNF-α and IL-2 in DNAM-1 deficient mice delays clearance in vivo of a persistent virus infection. Virology  2012 429:163-170  DOI:10.1016/j.virol.2012.04.006  PMID:22579352  PMCID:PMC3571684
    • Walsh, K. B., Teijaro, J. R., Zuniga, E. I., Welch, M. J., Fremgen, D. M., Blackburn, S. D., von Tiehl, K. F., Wherry, E. J., Flavell, R. A., Oldstone, M. B. A. Toll-like receptor 7 is required for effective adaptive immune responses that prevent persistent virus infection Cell Host & Microbe  2012 11:643-653  DOI:10.1016/j.chom.2012.04.016  PMID:22704624  PMCID:PMC3377981
    • Mahal, S. P., Jablonski, J., Suponitsky-Kroyter, I., Oelschlegel, A. M., Herva, M. E., Oldstone, M., Weissmann, C. Propagation of rml prions in mice expressing prp devoid of gpi anchor leads to formation of a novel, stable prion strain PLoS Pathogens  2012 8:e1002746  DOI:10.1371/journal.ppat.1002746  PMID:22685404  PMCID:PMC3369955
    • Ng, C. T., Nayak, B. P., Schmedt, C., Oldstone, M. B. A. Immortalized clones of fibroblastic reticular cells activate virus-specific t cells during virus infection Proceedings of the National Academy of Sciences of the United States of America  2012 109:7823-7828  DOI:10.1073/pnas.1205850109  PMID:22550183  PMCID:PMC3356638
    • Blasius, A. L., Krebs, P., Sullivan, B. M., Oldstone, M. B., Popkin, D. L. Slc15a4, a gene required for pDC sensing of TLR ligands, is required to control persistent viral infection PLoS Pathogens  2012 8:e1002915  DOI:10.1371/journal.ppat.1002915  PMID:23028315  PMCID:PMC3441671
    • Hara, Y., Kanagawa, M., Kunz, S., Yoshida-Moriguchi, T., Satz, J. S., Kobayashi, Y. M., Zhu, Z. H., Burden, S. J., Oldstone, M. B. A., Campbell, K. P. Like-acetylglucosaminyltransferase (large)-dependent modification of dystroglycan at thr-317/319 is required for laminin binding and arenavirus infection Proceedings of the National Academy of Sciences of the United States of America  2011 108:17426-17431  DOI:10.1073/pnas.1114836108  PMID:21987822  PMCID:PMC3198351
    • Walsh, K. B., Teijaro, J. R., Rosen, H., Oldstone, M. B. A. Quelling the storm: Utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm Immunologic Research  2011 51:15-25  DOI:10.1007/s12026-011-8240-z  PMID:21901448
    • Teijaro, J. R., Walsh, K. B., Cahalan, S., Fremgen, D. M., Roberts, E., Scott, F., Martinborough, E., Peach, R., Oldstone, M. B. A., Rosen, H. Endothelial cells are central orchestrators of cytokine amplification during influenza virus infection Cell  2011 146:979-990  DOI:10.1016/j.cell.2011.08.015  PMID:21925319  PMCID:PMC3176439
    • Ng, C. T., Sullivan, B. M., Oldstone, M. B. A. The role of dendritic cells in viral persistence Current Opinion in Virology  2011 1:160-166  DOI:10.1016/j.coviro.2011.05.006  PMID:21909344  PMCID:PMC3167161
    • Popkin, D. L., Teijaro, J. R., Lee, A. M., Lewicki, H., Emonet, S., de la Torre, J. C., Oldstone, M. Expanded potential for recombinant trisegmented lymphocytic choriomeningitis viruses: Protein production, antibody production, and in vivo assessment of biological function of genes of interest Journal of Virology  2011 85:7928-7932  DOI:10.1128/jvi.00486-11  PMID:21613399  PMCID:PMC3147893
    • Walsh, K. B., Teijaro, J. R., Wilker, P. R., Jatzek, A., Fremgen, D. M., Das, S. C., Watanabe, T., Hatta, M., Shinya, K., Suresh, M., Kawaoka, Y., Rosen, H., et al. Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus Proceedings of the National Academy of Sciences of the United States of America  2011 108:12018-12023  DOI:10.1073/pnas.1107024108  PMID:21715659  PMCID:PMC3142000
    • Krebs, P., Crozat, K., Popkin, D., Oldstone, M. B., Beutler, B. Disruption of myd88 signaling suppresses hemophagocytic lymphohistiocytosis in mice Blood  2011 117:6582-6588  DOI:10.1182/blood-2011-01-329607  PMID:21551232  PMCID:PMC3123024
    • Popkin, D. L., Teijaro, J. R., Sullivan, B. M., Urata, S., Rutschmann, S., de la Torre, J. C., Kunz, S., Beutler, B., Oldstone, M. Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner Cell Host & Microbe  2011 9:212-222  DOI:10.1016/j.chom.2011.02.006  PMID:21402360  PMCID:PMC3058147
    • Oldstone, M. B. A., Campbell, K. P. Decoding arenavirus pathogenesis: Essential roles for alpha-dystroglycan-virus interactions and the immune response Virology  2011 411:170-179  DOI:10.1016/j.virol.2010.11.023  PMID:21185048  PMCID:PMC3071849
    • Hara, Y., Balci-Hayta, B., Yoshida-Moriguchi, T., Kanagawa, M., de Bernabe, D. B. V., Gundesli, H., Willer, T., Satz, J. S., Crawford, R. W., Burden, S. J., Kunz, S., Oldstone, M. B. A., et al. A dystroglycan mutation associated with limb-girdle muscular dystrophy New England Journal of Medicine  2011 364:939-946  DOI:10.1056/NEJMoa1006939  PMID:21388311  PMCID:PMC3071687
    • Lee, A. M., Paulsson, J. F., Cruite, J., Andaya, A. A., Trifilo, M. J., Oldstone, M. B. A. Extraneural manifestations of prion infection in gpi-anchorless transgenic mice Virology  2011 411:1-8  DOI:10.1016/j.virol.2010.12.012  PMID:21227476  PMCID:PMC3039103
    • Sullivan, B. M., Emonet, S. F., Welch, M. J., Lee, A. M., Campbell, K. P., de la Torre, J. C., Oldstone, M. B. Point mutation in the glycoprotein of lymphocytic choriomeningitis virus is necessary for receptor binding, dendritic cell infection, and long-term persistence Proceedings of the National Academy of Sciences of the United States of America  2011 108:2969-2974  DOI:10.1073/pnas.1019304108  PMID:21270335  PMCID:PMC3041138
    • Ward, S. V., George, C. X., Welch, M. J., Liou, L. Y., Hahm, B., Lewicki, H., de la Torre, J. C., Samuel, C. E., Oldstone, M. B. RNA editing enzyme adenosine deaminase is a restriction factor for controlling measles virus replication that also is required for embryogenesis Proceedings of the National Academy of Sciences of the United States of America  2011 108:331-336  DOI:10.1073/pnas.1017241108  PMID:21173229  PMCID:PMC3017198
    • Alter, G., Kavanagh, D., Rihn, S., Luteijn, R., Brooks, D., Oldstone, M., van Lunzen, J., Altfeld, M. Il-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of hiv infection Journal of Clinical Investigation  2010 120:1905-1913  DOI:10.1172/jci40913  PMID:20440075  PMCID:PMC2877944
    • Liou, L. Y., Walsh, K. B., Vartanian, A. R., de Bernabe, D. B. V., Welch, M., Campbell, K. P., Oldstone, M. B. A., Kunz, S. Functional glycosylation of dystroglycan is crucial for thymocyte development in the mouse PLoS One  2010 5:e9915  DOI:10.1371/journal.pone.0009915  PMID:20369005  PMCID:PMC2848029
    • Walsh, K. B., Marsolais, D., Welch, M. J., Rosen, H., Oldstone, M. B. A. Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection Virology  2010 397:260-269  DOI:10.1016/j.virol.2009.08.043  PMID:19962171  PMCID:PMC2821988
    • Brooks, D. G., Walsh, K. B., Elsaesser, H., Oldstone, M. B. A. Il-10 directly suppresses cd4 but not cd8 t cell effector and memory responses following acute viral infection Proceedings of the National Academy of Sciences of the United States of America  2010 107:3018-3023  DOI:10.1073/pnas.0914500107  PMID:20133700  PMCID:PMC2840337
    • Yoshida-Moriguchi, T., Yu, L. P., Stalnaker, S. H., Davis, S., Kunz, S., Madson, M., Oldstone, M. B. A., Schachter, H., Wells, L., Campbell, K. P. O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding Science  2010 327:88-92  DOI:10.1126/science.1180512  PMID:20044576  PMCID:PMC2978000
    • Han, R., Kanagawa, M., Yoshida-Moriguchi, T., Rader, E. P., Ng, R. A., Michele, D. E., Muirhead, D. E., Kunz, S., Moore, S. A., Iannaccone, S. T., Miyake, K., McNeil, P. L. Basal lamina strengthens cell membrane integrity via the laminin g domain-binding motif of alpha-dystroglycan Proceedings of the National Academy of Sciences of the United States of America  2009 106:12573-12579  DOI:10.1073/pnas.0906545106  PMID:19633189  PMCID:PMC2715328
    • Whitby, L. R., Lee, A. M., Kunz, S., Oldstone, M. B. A., Boger, D. L. Characterization of lassa virus cell entry inhibitors: Determination of the active enantiomer by asymmetric synthesis Bioorganic & Medicinal Chemistry Letters  2009 19:3771-3774  DOI:10.1016/j.bmcl.2009.04.098  PMID:19428249  PMCID:PMC2742202
    • Oldstone, M. B. A. Anatomy of viral persistence PLoS Pathogens  2009 5:e1000523  DOI:10.1371/journal.ppat.1000523  PMID:19649277  PMCID:PMC2713431
    • Marsolais, D., Hahm, B., Walsh, K. B., Edelmann, K. H., McGavern, D., Hatta, Y., Kawaoka, Y., Rosen, H., Oldstone, M. B. A. A critical role for the sphingosine analog aal-r in dampening the cytokine response during influenza virus infection Proceedings of the National Academy of Sciences of the United States of America  2009 106:1560-1565  DOI:10.1073/pnas.0812689106  PMID:19164548  PMCID:PMC2635800
    • Horwitz, M. S., Efrat, S., Christen, U., von Herrath, M. G., Oldstone, M. B. A. Adenovirus e3 mhc inhibitory genes but not tnf/fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes Proceedings of the National Academy of Sciences of the United States of America  2009 106:19450-19454  DOI:10.1073/pnas.0910648106  PMID:19887639  PMCID:PMC2780797
    • Oldstone, M. B. A. Modeling subacute sclerosing panencephalitis in a transgenic mouse system: uncoding pathogenesis of disease and illuminating components of immune control Current Topics in Microbiology and Immunology  2009 330:31-54  DOI:10.1007/978-3-540-70617-5_2  PMID:19203103
    • Brooks, D. G., Ha, S. J., Elsaesser, H., Sharpe, A. H., Freeman, G. J., Oldstone, M. B. A. IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection Proceedings of the National Academy of Sciences of the United States of America  2008 105:20428-20433  DOI:10.1073/pnas.0811139106  PMID:19075244  PMCID:PMC2629263
    • Race, B., Meade-White, K., Oldstone, M. B. A., Race, R., Chesebro, B. Detection of prion infectivity in fat tissues of scrapie-infected mice PLoS Pathogens  2008 4:e1000232  DOI:10.1371/journal.ppat.1000232  PMID:19057664  PMCID:PMC2585054
    • Liou, L. Y., Blasius, A. L., Welch, M. J., Colonna, M., Oldstone, M. B. A., Zuniga, E. I. In vivo conversion of bm plasmacytoid dc into cd11b(+) conventional dc during virus infection European Journal of Immunology  2008 38:3388-3394  DOI:10.1002/eji.200838282  PMID:18979509  PMCID:PMC2897746
    • Zuniga, E. I., Liou, L. Y., Mack, L., Mendoza, M., Oldstone, M. B. A. Persistent virus infection inhibits type i interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections Cell Host & Microbe  2008 4:374-386  DOI:10.1016/j.chom.2008.08.016  PMID:18854241  PMCID:PMC2875928
    • Trifilo, M. J., Sanchez-Alavez, M., Solforosi, L., Bernard-Trifilo, J., Kunz, S., McGavern, D., Oldstone, M. B. A. Scrapie-induced defects in learning and memory of transgenic mice expressing anchorless prion protein are associated with alterations in the gamma aminobutyric acid-ergic pathway Journal of Virology  2008 82:9890-9899  DOI:10.1128/jvi.00486-08  PMID:18667494  PMCID:PMC2566293
    • Lee, A. M., Rojek, J. M., Spiropoulou, C. F., Gundersen, A. T., Jin, W., Shaginian, A., York, J., Nunberg, J. H., Boger, D. L., Oldstone, M. B. A., Kunz, S. Unique small molecule entry inhibitors of hemorrhagic fever arenaviruses Journal of Biological Chemistry  2008 283:18734-18742  DOI:10.1074/jbc.M802089200  PMID:18474596  PMCID:PMC2441566
    • Brooks, D. G., Lee, A. M., Elsaesser, H., McGavern, D. B., Oldstone, M. B. A. Il-10 blockade facilitates DNA vaccine-induced t cell responses and enhances clearance of persistent virus infection Journal of Experimental Medicine  2008 205:533-541  DOI:10.1084/jem.20071948  PMID:18332180  PMCID:PMC2275377
    • Marsolais, D., Hahm, B., Edelmann, K. H., Walsh, K. B., Guerrero, M., Hatta, Y., Kawaoka, Y., Roberts, E., Oldstone, M. B. A., Rosen, H. Local not systemic modulation of dendritic cell s1p receptors in lung blunts virus-specific immune responses to influenza Molecular Pharmacology  2008 74:896-903  DOI:10.1124/mol.108.048769  PMID:18577684  PMCID:PMC2574812
    • Rothlin, C. V., Ghosh, S., Zuniga, E. I., Oldstone, M. B. A., Lemke, G. Tam receptors are pleiotropic inhibitors of the innate immune response Cell  2007 131:1124-1136  DOI:10.1016/j.cell.2007.10.034  PMID:18083102
    • Rojek, J. M., Campbell, K. P., Oldstone, M. B. A., Kunz, S. Old world arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cell Molecular Biology of the Cell  2007 18:4493-4507  DOI:10.1091/mbc.E07-04-0374  PMID:17761532  PMCID:PMC2043543
    • Ahmed, R., Oldstone, M. B. A., Palese, P. Protective immunity and susceptibility to infectious diseases: Lessons from the 1918 influenza pandemic Nature Immunology  2007 8:1188-1193  DOI:10.1038/ni1530  PMID:17952044
    • Trifilo, M. J., Ying, G., Teng, C., Oldstone, M. B. A. Chronic wasting disease of deer and elk in transgenic mice: Oral transmission and pathobiology Virology  2007 365:136-143  DOI:10.1016/j.virol.2007.03.032  PMID:17451773  PMCID:PMC1950321
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    • Homann, D., Lewicki, H., Brooks, D., Eberlein, J., Mallet-Designe, V., Teyton, L., Oldstone, M. B. A. Mapping and restriction of a dominant viral CD4(+) T cell core epitope by both MHC class I and MHC class II Virology  2007 363:113-123  DOI:10.1016/j.virol.2006.12.025  PMID:17320138  PMCID:PMC1976554
    • Georgel, P., Jiang, Z. F., Kunz, S., Janssen, E., Mols, J., Hoebe, K., Bahram, S., Oldstone, M. B. A., Beutler, B. Vesicular stomatitis virus glycoprotein g activates a specific antiviral toll-like receptor 4-dependent pathway Virology  2007 362:304-313  DOI:10.1016/j.virol.2006.12.032  PMID:17292937
    • Meade-White, K., Race, B., Trifilo, M., Bossers, A., Favara, C., Lacasse, R., Miller, M., Williams, E., Oldstone, M., Race, R., Chesebro, B. Resistance to chronic wasting disease in transgenic mice expressing a naturally occurring allelic variant of deer prion protein Journal of Virology  2007 81:4533-4539  DOI:10.1128/jvi.02762-06  PMID:17314157
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    • Hahm, B., Cho, J. H., Oldstone, M. B. A. Measles virus-dendritic cell interaction via slam inhibits innate immunity: Selective signaling through tlr4 but not other tlrs mediates suppression of il-12 synthesis Virology  2007 358:251-257  DOI:10.1016/j.virol.2006.10.04  PMID:17070884
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    • Kunz, S., Rojek, J. M., Roberts, A. J., McGavern, D. B., Oldstone, M. B. A., de la Torre, J. C. Altered central nervous system gene expression caused by congenitally acquired persistent infection with lymphocytic choriomeningitis virus Journal of Virology  2006 80:9082-9092  DOI:10.1128/jvi.00795-06  PMID:16940520
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    • Tishon, A., Lewicki, H., Andaya, A., McGavern, D., Martin, L., Oldstone, M. B. A. Cd4 t cell control primary measles virus infection of the cns: Regulation is dependent on combined activity with either cd8 t cells or with b cells: Cd4, cd8 or b cells alone are ineffective Virology  2006 347:234-245  DOI:10.1016/j.virol.2006.01.050  PMID:16529787
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    • Oldstone, M. B. A., Dales, S., Tishon, A., Lewicki, H., Martin, L. A role for dual viral hits in causation of subacute sclerosing panencephalitis Journal of Experimental Medicine  2005 202:1185-1190  DOI:10.1084/jem.20051376  PMID:16260490  PMCID:PMC1350947
    • Kunz, S., Rojek, J. M., Kanagawa, M., Spiroroulou, C. F., Barresi, R., Campbell, K. P., Oldstone, M. B. A. Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase large is critical for virus binding Journal of Virology  2005 79:14282-14296  DOI:10.1128/jvi.79.22.14282-14296.2005  PMID:16254363
    • Rhode, A., Pauza, M. E., Barral, A. M., Rodrigo, E., Oldstone, M. B. A., von Herrath, M. G., Christen, U. Islet-specific expression of cxcl10 causes spontaneous islet infiltration and accelerates diabetes development Journal of Immunology  2005 175:3516-3524  PMID:16148094
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    • Criado, J. R., Sanchez-Alavez, M., Conti, B., Giacchino, J. L., Wills, D. N., Henriksen, S. J., Race, R., Manson, J. C., Chesebro, B., Oldstone, M. B. A. Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons Neurobiology of Disease  2005 19:255-265  DOI:10.1016/j.nbd.2004.01.001  PMID:15837581
    • Kunz, S., Rojek, J. M., Perez, M., Spiropoulou, C. F., Oldstone, M. B. A. Characterization of the interaction of lassa fever virus with its cellular receptor alpha-dystroglycan Journal of Virology  2005 79:5979-5987  DOI:10.1128/jvi.79.10.5979-5987.2005  PMID:15857984
    • Hahm, B., Trifilo, M. J., Zuniga, E. I., Oldstone, M. B. A. Viruses evade the immune system through type i interferon-mediated stat2-dependent, but stat1-independent, signaling Immunity  2005 22:247-257  DOI:10.1016/j.immuni.2005.01.005  PMID:15723812
    • Oldstone, M. B. A. Book review: Spores, plagues, and history: the story of anthrax Bulletin of the History of Medicine  2005 79:381-383  DOI:10.1353/bhm.2005.0083
    • Oldstone, M. B. A. Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry Current Topics in Microbiology and Immunology  2005 296:65-87  PMID:16329191
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    • Oldstone, M. B. A. MMR and autism: what parents need to know Nature  2004 432:275-276  DOI:10.1038/432275a
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    • Christen, U., Edelmann, K. H., McGavern, D. B., Wolfe, T., Coon, B., Teague, M. K., Miler, S. D., Oldstone, M. B. A., von Herrath, M. G. A viral epitope that mimics a self antigen can accelerate but nit initiate autoimmune diabetes Journal of Clinical Investigation  2004 114:1290-1298  DOI:10.1172/jci200422557  PMID:15520861
    • Naniche, D., Garenne, M., Rae, C., Manchester, M., Buchta, R., Brodine, S. K., Oldstone, M. B. A. Decrease in measles virus-specific cd4 t cell memory in vaccinated subjects Journal of Infectious Diseases  2004 190:1387-1395  DOI:10.1086/424571  PMID:15378430
    • Kunz, S., Calder, L., Oldstone, M. B. A. Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virus Virology  2004 325:207-215  DOI:10.1016/j.virol.2004.04.044  PMID:15246261
    • Kunz, S., Sevilla, N., Rojek, J. M., Oldstone, M. B. A. Use of alternative receptors different than alpha-dystroglycan by selected isolates of lymphocytic choriomeningitis virus Virology  2004 325:432-445  DOI:10.1016/j.virol.2004.05.009  PMID:15246281
    • Kanagawa, M., Saito, F., Kunz, S., Yoshida-Moriguchi, T., Barresi, R., Kobayashi, Y. M., Muschler, J., Dumanski, J. P., Michele, D. E., Oldstone, M. B. A., Campbell, K. P. Molecular recognition by large is essential for expression of functional dystroglycan Cell  2004 117:953-964  DOI:10.1016/j.cell.2004.06.003  PMID:15210115
    • Lenz, D. C., Kurz, S. K., Lemmens, E., Schoenberger, S. P., Sprent, J., Oldstone, M. B. A., Homann, D. Il-7 regulates basal homeostatic proliferation of antiviral cd4(+)t cell memory Proceedings of the National Academy of Sciences of the United States of America  2004 101:9357-9362  DOI:10.1073/pnas.0400640101  PMID:15197277  PMCID:PMC438981
    • Hahm, B., Arbour, N., Oldstone, M. B. A. Measles virus interacts with human slam receptor on dendritic cells to cause immuno suppression Virology  2004 323:292-302  DOI:10.1016/j.virol.2004.03.011  PMID:15193925  PMCID:PMC5050034
    • Homann, D., McGavern, D. B., Oldstone, M. B. A. Visualizing the viral burden: Phenotypic and functional alterations of t cells and apcs during persistent infection Journal of Immunology  2004 172:6239-6250  PMID:15128812
    • Edelmann, K. H., Richardson-Burns, S., Alexopoulou, L., Tyler, K. L., Flavell, R. A., Oldstone, M. B. A. Does toll-like receptor 3 play a biological role in virus infections? Virology  2004 322:231-238  DOI:10.1016/j.virol.2004.01.033  PMID:15110521
    • Solforosi, L., Criado, J. R., McGavern, D. B., Wirz, S., Sanchez-Alavez, M., Sugama, S., DeGiorgio, L. A., Volpe, B. T., Wiseman, E., Abalos, G., Masliah, E., Gilden, D., et al. Cross-linking cellular prion protein triggers neuronal apoptosis in vivo Science  2004 303:1514-1516  DOI:10.1126/science.1094273  PMID:14752167
    • Sevilla, N., McGavern, D. B., Teng, C., Kunz, S., Oldstone, M. B. A. Viral targeting of hematopoietic progenitors and inhibition of dc maturation as a dual strategy for immune subversion Journal of Clinical Investigation  2004 113:737-745  DOI:10.1172/jci20243  PMID:14991072
    • Christen, U., Benke, D., Wolfe, T., Rodrigo, E., Rhode, A., Hughes, A. C., Oldstone, M. B. A., von Herrath, M. G. Cure of prediabetic mice by viral infections involves lymphocyte recruitment along an IP-10 gradient Journal of Clinical Investigation  2004 113:74-84  DOI:10.1172/jci200417005  PMID:14702111  PMCID:PMC300760
    • Oldstone, M. B. A. Future trends in neurovirology: Neuronal survival during virus infection and analysis of virus-specific t cells in central nervous system tissues Journal of Neurovirology  2004 10:207-215  DOI:10.1080/13550280490468438  PMID:15371150
    • Rambukkana, A., Kunz, S., Min, J., Campbell, K. P., Oldstone, M. B. A. Targeting schwann cells by nonlytic arenaviral infection selectively inhibits myelination Proceedings of the National Academy of Sciences of the United States of America  2003 100:16071-16076  DOI:10.1073/pnas.2232366100  PMID:14657400  PMCID:PMC307694
    • Christen, U., McGavern, D. B., Luster, A. D., von Herrath, M. G., Oldstone, M. B. A. Among cxcr3 chemokines, ifn-gamma-inducible protein of 10 kda (cxc chemokine ligand (cxcl) 10) but not monokine induced by ifn-gamma (cxcl9) imprints a pattern for the subsequent development of autoimmune disease Journal of Immunology  2003 171:6838-6845  PMID:14662890
    • Kunz, S., Campbell, K. P., Oldstone, M. B. A. Alpha-dystroglycan can mediate arenavirus infection in the absence of beta-dystroglycan Virology  2003 316:213-220  DOI:10.1016/s0042-6822(03)00592-0  PMID:14644604
    • Kunz, S., Edelmann, K. H., de la Torre, J. C., Gorney, R., Oldstone, M. B. A. Mechanisms for lymphocytic choriomeningitis virus glycoprotein cleavage, transport, and incorporation into virions Virology  2003 314:168-178  DOI:10.1016/s0042-6822(03)00421-5  PMID:14517070
    • Stratmann, T., Martin-Orozco, N., Mallet-Designe, V., Poirot, L., McGavern, D., Losyev, G., Dobbs, C. M., Oldstone, M. B. A., Yoshida, K., Kikutani, H., Mathis, D., Benoist, C., et al. Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity Journal of Clinical Investigation  2003 112:902-914  DOI:10.1172/jci200318337  PMID:12975475  PMCID:PMC193666
    • Arbour, N., Holz, A., Sipe, J. C., Naniche, D., Romine, J. S., Zyroff, J., Oldstone, M. B. A. A new approach for evaluating antigen-specific t cell responses to myelin antigens during the course of multiple sclerosis Journal of Neuroimmunology  2003 137:197-209  DOI:10.1016/s0165-5728(03)00080-8  PMID:12667664
    • Slifka, M. K., Homann, D., Tishon, A., Pagarigan, R., Oldstone, M. B. A. Measles virus infection results in suppression of both innate and adaptive immune responses to secondary bacterial infection Journal of Clinical Investigation  2003 111:805-810  DOI:10.1172/jci200313603  PMID:12639986
    • Hahm, B., Arbour, N., Naniche, D., Homann, D., Manchester, M., Oldstone, M. B. A. Measles virus infects and suppresses proliferation of t lymphocytes from transgenic mice bearing human signaling lymphocytic activation molecule Journal of Virology  2003 77:3505-3515  DOI:10.1128/jvi.77.6.3505-3515.2003  PMID:12610126
    • Lewicki, H., Tishon, A., Homann, D., Mazarguil, H., Laval, F., Asensio, V. C., Campbell, I. L., DeArmond, S., Coon, B., Teng, C., Gairin, J. E., Oldstone, M. B. A. T cells infiltrate the brain in murine and human transmissible spongiform encephalopathies Journal of Virology  2003 77:3799-3808  DOI:10.1128/jvi.77.6.3799-3808.2003  PMID:12610154
    • Slifka, M. K., Blattman, J. N., Sourdive, D. J. D., Liu, F., Huffman, D. L., Wolfe, T., Hughes, A., Oldstone, M. B. A., Ahmed, R., von Herrath, M. G. Preferential escape of subdominant cd8(+) t cells during negative selection results in an altered antiviral t cell hierarchy Journal of Immunology  2003 170:1231-1239  PMID:12538681
    • Mallet-Designe, V. I., Stratmann, T., Homann, D., Carbone, F., Oldstone, M. B. A., Teyton, L. Detection of low-avidity CD4(+) T cells using recombinant artificial APC: following the antiovalbumin immune response Journal of Immunology  2003 170:123-131  PMID:12496391
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    • McGavern, D. B., Homann, D., Oldstone, M. B. A. T cells in the central nervous system: The delicate balance between viral clearance and disease Journal of Infectious Diseases  2002 186:S145-S151  DOI:10.1086/344264  PMID:12424690
    • McGavern, D. B., Christen, U., Oldstone, M. B. A. Molecular anatomy of antigen-specific cd8(+) t cell engagement and synapse formation in vivo Nature Immunology  2002 3:918-925  DOI:10.1038/ni843  PMID:12352968  PMCID:PMC2481514
    • Oldstone, M. B. A., Homann, D., Lewicki, H., Stevenson, D. One, two, or three step: Measles virus receptor dance Virology  2002 299:162-163  DOI:10.1006/viro.2002.1507  PMID:12202218
    • Oldstone, M. B. A. Travels along the viral-immunobiology highway Immunological Reviews  2002 185:54-68  DOI:10.1034/j.1600-065X.2002.18507.x  PMID:12190922
    • Oldstone, M. B. A., Race, R., Thomas, D., Lewicki, H., Homann, D., Smelt, S., Holz, A., Koni, P., Lo, D., Chesebro, B., Flavell, R. Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: Evidence against dendritic cell involvement in neuroinvasion Journal of Virology  2002 76:4357-4363  DOI:10.1128/jvi.76.9.4357-4363.2002  PMID:11932402
    • Spiropoulou, C. F., Kunz, S., Rollin, P. E., Campbell, K. P., Oldstone, M. B. A. New world arenavirus clade c, but not clade a and b viruses, utilizes alpha-dystroglycan as its major receptor Journal of Virology  2002 76:5140-5146  DOI:10.1128/jvi.76.10.5140-5146.2002  PMID:11967329
    • Arbour, N., Naniche, D., Homann, D., Davis, R. J., Flavell, R. A., Oldstone, M. B. A. c-Jun NH2-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity Journal of Experimental Medicine  2002 195:801-810  DOI:10.1084/jem.20011481  PMID:11927625  PMCID:PMC2193720
    • Oldstone, M. B. A. Arenaviruses i - the epidemiology, molecular and cell biology of arenaviruses - preface Arenaviruses I  2002 262:V-XII  PMID:11987810
    • Oldstone, M. B. A. Biology and pathogenesis of lymphocytic choriomeningitis virus infection Arenaviruses II  2002 263:83-117  PMID:11987822
    • Kunz, S., Borrow, P., Oldstone, M. B. A. Receptor structure, binding, and cell entry of arenaviruses Arenaviruses I  2002 262:111-137  PMID:11987803
    • Patterson, J. B., Cornu, T. I., Redwine, J., Dales, S., Lewicki, H., Holz, A., Thomas, D., Billeter, M. A., Oldstone, M. B. A. Evidence that the hypermutated m protein of a subacute sclerosing panencephalitis measles virus actively contributes to the chronic progressive cns disease Virology  2001 291:215-225  DOI:10.1006/viro.2001.1182  PMID:11878891
    • Holz, A., Brett, K., Oldstone, M. B. A. Constitutive beta cell expression of il-12 does not perturb self-tolerance but intensifies established autoimmune diabetes Journal of Clinical Investigation  2001 108:1749-1758  DOI:10.1172/jci200113915  PMID:11748258
    • Kunz, S., Sevilla, N., McGavern, D. B., Campbell, K. P., Oldstone, M. B. A. Molecular analysis of the interaction of lcmv with its cellular receptor alpha-dystroglycan Journal of Cell Biology  2001 155:301-310  DOI:10.1083/jcb.200104103  PMID:11604425  PMCID:PMC2198839
    • Homann, D., Teyton, L., Oldstone, M. B. A. Differential regulation of antiviral T-cell immunity results in stable CD8(+) but declining CD4(+) T-cell memory Nature Medicine  2001 7:913-919  DOI:10.1038/90950  PMID:11479623
    • Oldstone, M. B. A., Lewicki, H., Homann, D., Nguyen, C., Julien, S., Gairin, J. E. Common antiviral cytotoxic t-lymphocyte epitope for diverse arenaviruses Journal of Virology  2001 75:6273-6278  DOI:10.1128/jvi.75.14.6273-6278.2001  PMID:11413293
    • Hudrisier, D., Riond, J., Burlet-Schiltz, O., von Herrath, M. G., Lewicki, H., Monsarrat, B., Oldstone, M. B. A., Gairin, J. E. Structural and functional identification of major histocompatibility complex class i-restricted self-peptides as naturally occurring molecular mimics of viral antigens - possible role in cd8(+) t cell-mediated, virus-induced autoimmune disease Journal of Biological Chemistry  2001 276:19396-19403  DOI:10.1074/jbc.M008864200  PMID:11278441
    • Bureau, J. F., Le Goff, S., Thomas, D., Parlow, A. F., de la Torre, J. C., Homann, D., Brahic, M., Oldstone, M. B. A. Disruption of differentiated functions during viral infection in vivo - v. Mapping of a locus involved in susceptibility of mice to growth hormone deficiency due to persistent lymphocytic choriomeningitis virus infection Virology  2001 281:61-66  DOI:10.1006/viro.2000.0800  PMID:11222096
    • Patterson, J. B., Manchester, M., Oldstone, M. B. A. Disease model: Dissecting the pathogenesis of the measles virus Trends in Molecular Medicine  2001 7:85-88  DOI:10.1016/s1471-4914(01)01918-9  PMID:11286761
    • Smelt, S. C., Borrow, P., Kunz, S., Cao, W., Tishon, A., Lewicki, H., Campbell, K. P., Oldstone, M. B. A. Differences in affinity of binding of lymphocytic choriomeningitis virus strains to the cellular receptor alpha-dystroglycan correlate with viral tropism and disease kinetics Journal of Virology  2001 75:448-457  DOI:10.1128/jvi.75.1.448-457.2001  PMID:11119613
    • Holz, A., Dyrberg, T., Hagopian, W., Homann, D., von Herrath, M., Oldstone, M. B. A. Neither b lymphocytes nor antibodies directed against self antigens of the islets of langerhans are required for development of virus-induced autoimmune diabetes Journal of Immunology  2000 165:5945-5953  PMID:11067957
    • Sevilla, N., Kunz, S., Holz, A., Lewicki, H., Homann, D., Yamada, H., Campbell, K. P., de la Torre, J. C., Oldstone, M. B. A. Immunosuppression and resultant viral persistence by specific viral targeting of dendritic cells Journal of Experimental Medicine  2000 192:1249-1260  DOI:10.1084/jem.192.9.1249  PMID:11067874
    • Tishon, A., LaFace, D. M., Lewicki, H., van Binnendijk, R. S., Osterhaus, A., Oldstone, M. B. A. Transgenic mice expressing human hla and cd8 molecules generate hla-restricted measles virus cytotoxic t lymphocytes of the same specificity as humans with natural measles virus infection Virology  2000 275:286-293  DOI:10.1006/viro.2000.0517  PMID:10998329
    • Naniche, D., Oldstone, M. B. A. Generalized immunosuppression: How viruses undermine the immune response Cellular and Molecular Life Sciences  2000 57:1399-1407  DOI:10.1007/pl00000625  PMID:11078019
    • Naniche, D., Yeh, A., Eto, D., Manchester, M., Friedman, R. M., Oldstone, M. B. A. Evasion of host defenses by measles virus: Wild-type measles virus infection interferes with induction of alpha/beta interferon production Journal of Virology  2000 74:7478-7484  DOI:10.1128/jvi.74.16.7478-7484.2000  PMID:10906201
    • Manchester, M., Eto, D. S., Valsamakis, A., Liton, P. B., Fernandez-Munoz, R., Rota, P. A., Bellini, W. J., Forthal, D. N., Oldstone, M. B. A. Clinical isolates of measles virus use cd46 as a cellular receptor? Journal of Virology  2000 74:3967-3974  DOI:10.1128/jvi.74.9.3967-3974.2000  PMID:10756008
    • Lee, K. J., Novella, I. S., Teng, M. N., Oldstone, M. B. A., de la Torre, J. C. NP and l proteins of lymphocytic choriomeningitis virus (LCMV) are sufficient for efficient transcription and replication of LCMV genomic RNA analogs Journal of Virology  2000 74:3470-3477  DOI:10.1128/jvi.74.8.3470-3477.2000  PMID:10729120
    • Sevilla, N., Homann, D., von Herrath, M., Rodriguez, F., Harkins, S., Whitton, J. L., Oldstone, M. B. A. Virus-induced diabetes in a transgenic model: Role of cross-reacting viruses and quantitation of effector t cells needed to cause disease Journal of Virology  2000 74:3284-3292  DOI:10.1128/jvi.74.7.3284-3292.2000  PMID:10708445
    • von Herrath, M. G., Berger, D. P., Homann, D., Tishon, T., Sette, A., Oldstone, M. B. A. Vaccination to treat persistent viral infection Virology  2000 268:411-419  DOI:10.1006/viro.1999.0130  PMID:10704349
    • Patterson, J. B., Thomas, D., Lewicki, H., Billeter, M. A., Oldstone, M. B. A. V and c proteins of measles virus function as virulence factors in vivo Virology  2000 267:80-89  DOI:10.1006/viro.1999.0118  PMID:10648185
    • Berger, D. P., Homann, D., Oldstone, M. B. A. Defining parameters for successful immunocytotherapy of persistent viral infection Virology  2000 266:257-263  DOI:10.1006/viro.1999.0074  PMID:10639312
    • Holz, A., Bielekova, B., Martin, R., Oldstone, M. B. A. Myelin-associated oligodendrocytic basic protein: Identification of an encephalitogenic epitope and association with multiple sclerosis Journal of Immunology  2000 164:1103-1109  PMID:10623862
    • Oldstone, M. B. A., Levine, A. J. Virology in the next millennium Cell  2000 100:139-142  DOI:10.1016/s0092-8674(00)81690-6  PMID:10647938
    • Race, R., Oldstone, M., Chesebro, B. Entry versus blockade of brain infection following oral or intraperitoneal scrapie administration: Role of prion protein expression in peripheral nerves and spleen Journal of Virology  2000 74:828-833  DOI:10.1128/jvi.74.2.828-833.2000  PMID:10623745
    • Hudrisier, D., Riond, J., Mazarguil, H., Oldstone, M. B. A., Gairin, J. E. Genetically encoded and post-translationally modified forms of a major histocompatibility complex class i-restricted antigen bearing a glycosylation motif are independently processed and co-presented to cytotoxic t lymphocytes Journal of Biological Chemistry  1999 274:36274-36280  DOI:10.1074/jbc.274.51.36274  PMID:10593916
    • Puglielli, M. T., Browning, J. L., Brewer, A. W., Schreiber, R. D., Shieh, W. J., Altman, J. D., Oldstone, M. B. A., Zaki, S. R., Ahmed, R. Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway Nature Medicine  1999 5:1370-1374  PMID:10581078
    • Oldstone, M. B. A., Lewicki, H., Thomas, D., Tishon, A., Dales, S., Patterson, J., Manchester, M., Homann, D., Naniche, D., Holz, A. Measles virus infection in a transgenic model: Virus-induced immunosuppression and central nervous system disease Cell  1999 98:629-640  DOI:10.1016/s0092-8674(00)80050-1  PMID:10490102
    • Homann, D., Dyrberg, T., Petersen, J., Oldstone, M. B. A., von Herrath, M. G. Insulin in oral immune "tolerance": A one-amino acid change in the b chain makes the difference Journal of Immunology  1999 163:1833-1838  PMID:10438916
    • Berger, D. P., Naniche, D., Crowley, M. T., Koni, P. A., Flavell, R. A., Oldstone, M. B. A. Lymphotoxin-beta-deficient mice show defective antiviral immunity Virology  1999 260:136-147  DOI:10.1006/viro.1999.9811  PMID:10405365
    • Eto, D. S., Oldstone, M. B. A., Manchester, M. Characterization of the inflammatory response during acute measles encephalitis in nse-cd46 transgenic mice Journal of Neuroimmunology  1999 96:207-217  DOI:10.1016/s0165-5728(99)00036-3  PMID:10337919
    • Oldstone, M. B. A., von Herrath, M., Lewicki, H., Hudrisier, D., Whitton, J. L., Gairin, J. E. Use of a high-affinity peptide that aborts mhc-restricted cytotoxic t lymphocyte activity against multiple viruses in vitro and virus-induced immunopathologic disease in vivo Virology  1999 256:246-257  DOI:10.1006/viro.1998.9593  PMID:10191190
    • Patterson, J. B., Scheiflinger, F., Manchester, M., Yilma, T., Oldstone, M. B. A. Structural and functional studies of the measles virus hemagglutinin: Identification of a novel site required for cd46 interaction Virology  1999 256:142-151  DOI:10.1006/viro.1999.9644  PMID:10087234
    • Naniche, D., Reed, S. I., Oldstone, M. B. A. Cell cycle arrest during measles virus infection: A g(0)-like block leads to suppression of retinoblastoma protein expression Journal of Virology  1999 73:1894-1901  PMID:9971768  PMCID:PMC104430
    • Horwitz, M. S., Evans, C. F., Klier, F. G., Oldstone, M. B. A. Detailed in vivo analysis of interferon-gamma induced major histocompatibility complex expression in the central nervous system: Astrocytes fail to express major histocompatibility complex class i and ii molecules Laboratory Investigation  1999 79:235-242  PMID:10068211
    • Cao, W., Henry, M. D., Borrow, P., Yamada, H., Elder, J. H., Ravkov, E. V., Nichol, S. T., Compans, R. W., Campbell, K. P., Oldstone, M. B. A. Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and lassa fever virus Science  1998 282:2079-2081  DOI:10.1126/science.282.5396.2079  PMID:9851928
    • Homann, D., Tishon, A., Berger, D. P., Weigle, W. O., von Herrath, M. G., Oldstone, M. B. A. Evidence for an underlying cd4 helper and cd8 t-cell defect in b-cell-deficient mice: Failure to clear persistent virus infection after adoptive immunotherapy with virus-specific memory cells from mu mt/mu mt mice Journal of Virology  1998 72:9208-9216  PMID:9765468  PMCID:PMC110340
    • von Herrath, M. G., Coon, B., Lewicki, H., Mazarguil, H., Gairin, J. E., Oldstone, M. B. A. In vivo treatment with a mhc class i-restricted blocking peptide can prevent virus-induced autoimmune diabetes Journal of Immunology  1998 161:5087-5096  PMID:9794447
    • Oldstone, M. B. A. Molecular mimicry and immune-mediated diseases FASEB Journal  1998 12:1255-1265  PMID:9761770
    • Borrow, P., Tough, D. F., Eto, D., Tishon, A., Grewal, I. S., Sprent, J., Flavell, R. A., Oldstone, M. B. A. Cd40 ligand-mediated interactions are involved in the generation of memory cd8(+) cytotoxic t lymphocytes (ctl) but are not required for the maintenance of ctl memory following virus infection Journal of Virology  1998 72:7440-7449  PMID:9696840
    • Oldstone, M. B. Viral persistence: Mechanisms and consequences Current Opinion in Microbiology  1998 1:436-441  DOI:10.1016/s1369-5274(98)80062-3  PMID:10066504
    • von Herrath, M. G., Holz, A., Homann, D., Oldstone, M. B. A. Role of viruses in type i diabetes Seminars in Immunology  1998 10:87-100  DOI:10.1006/smim.1997.0108  PMID:9529659
    • Raeber, A. J., Race, R. E., Brandner, S., Priola, S. A., Sailer, A., Bessen, R. A., Mucke, L., Manson, J., Aguzzi, A., Oldstone, M. B. A., Weissmann, C., Chesebro, B. Astrocyte-specific expression of hamster prion protein (prp) renders prp knockout mice susceptible to hamster scrapie EMBO Journal  1997 16:6057-6065  DOI:10.1093/emboj/16.20.6057  PMID:9321385  PMCID:PMC1326289
    • Oldstone, M. B. A. Viruses and autoimmune diseases Scandinavian Journal of Immunology  1997 46:320-325  DOI:10.1046/j.1365-3083.1997.d01-145.x  PMID:9350280
    • VonHerrath, M. G., Efrat, S., Oldstone, M. B. A., Horwitz, M. S. Expression of adenoviral e3 transgenes in beta cells prevents autoimmune diabetes Proceedings of the National Academy of Sciences of the United States of America  1997 94:9808-9813  DOI:10.1073/pnas.94.18.9808  PMID:9275207
    • Horwitz, M. S., Evans, C. F., McGavern, D. B., Rodriguez, M., Oldstone, M. B. A. Primary demyelination in transgenic mice expressing interferon-gamma Nature Medicine  1997 3:1037-1041  DOI:10.1038/nm0997-1037  PMID:9288735
    • Brot, M. D., Rall, G. F., Oldstone, M. B. A., Koob, G. F., Gold, L. H. Deficits in discriminated learning remain despite clearance of long-term persistent viral infection in mice Journal of Neurovirology  1997 3:265-273  PMID:9291234
    • Grewal, I. S., Borrow, P., Pamer, E. G., Oldstone, M. B. A., Flavell, R. A. The cd40-cd154 system in anti-infective host defense Current Opinion in Immunology  1997 9:491-497  DOI:10.1016/s0952-7915(97)80100-8  PMID:9287184
    • Hudrisier, D., Oldstone, M. B. A., Gairin, J. E. The signal sequence of lymphocytic choriomeningitis virus contains an immunodominant cytotoxic t cell epitope that is restricted by both h-2d(b) and h-2k(b) molecules Virology  1997 234:62-73  DOI:10.1006/viro.1997.8627  PMID:9234947
    • Manchester, M., Gairin, J. E., Patterson, J. E., Alvarez, J., Liszewski, M. K., Eto, D. S., Atkinson, J. P., Oldstone, M. B. A. Measles virus recognizes its receptor, cd46, via two distinct binding domains within scr1-2 Virology  1997 233:174-184  DOI:10.1006/viro.1997.8581  PMID:9201227
    • Rall, G. F., Manchester, M., Daniels, L. R., Callahan, E. M., Belman, A. R., Oldstone, M. B. A. A transgenic mouse model for measles virus infection of the brain Proceedings of the National Academy of Sciences of the United States of America  1997 94:4659-4663  DOI:10.1073/pnas.94.9.4659  PMID:9114047
    • Cao, W., Oldstone, M. B. A., DelaTorre, J. C. Viral persistent infection affects both transcriptional and posttranscriptional regulation of neuron-specific molecule GAP43 Virology  1997 230:147-154  DOI:10.1006/viro.1997.8458  PMID:9143270
    • VonHerrath, M. G., Coon, B., Oldstone, M. B. A. Low-affinity cytotoxic t-lymphocytes require ifn-gamma to clear an acute viral infection Virology  1997 229:349-359  DOI:10.1006/viro.1997.8442  PMID:9126248
    • Borrow, P., Lewicki, H., Wei, X. P., Horwitz, M. S., Peffer, N., Meyers, H., Nelson, J. A., Gairin, J. E., Hahn, B. H., Oldstone, M. B. A., Shaw, G. M. Antiviral pressure exerted by hiv-1-specific cytotoxic t lymphocytes (ctls) during primary infection demonstrated by rapid selection of ctl escape virus Nature Medicine  1997 3:205-211  DOI:10.1038/nm0297-205  PMID:9018240
    • Oldstone, M. B. A. How viruses escape from cytotoxic t lymphocytes: Molecular parameters and players Virology  1997 234:179-185  DOI:10.1006/viro.1997.8674  PMID:9268148
    • von Herrath, M. G., Oldstone, M. B. A. Interferon-gamma is essential for destruction of beta cells and development of insulin-dependent diabetes mellitus Journal of Experimental Medicine  1997 185:531-539  DOI:10.1084/jem.185.3.531  PMID:9053453
    • von Herrath, M. G., Homann, D., Gairin, J. E., Oldstone, M. B. A. Pathogenesis and treatment of virus-induced autoimmune diabetes: novel insights gained from the RIP-LCMV transgenic mouse model Biochemical Society Transactions  1997 25:630-635  PMID:9191170
    • Teng, M. N., Borrow, P., Oldstone, M. B. A., delaTorre, J. C. A single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with the ability to cause growth hormone deficiency syndrome Journal of Virology  1996 70:8438-8443  PMID:8970965  PMCID:PMC190933
    • BuesaGomez, J., Teng, M. N., Oldstone, C. E., Oldstone, M. B. A., DelaTorre, J. C. Variants able to cause growth hormone deficiency syndrome are present within the disease-nil WE strain of lymphocytic choriomeningitis virus Journal of Virology  1996 70:8988-8992  PMID:8971029  PMCID:PMC190997
    • Evans, C. F., Horwitz, M. S., Hobbs, M. V., Oldstone, M. B. A. Viral infection of transgenic mice expressing a viral protein in oligodendrocytes leads to chronic central nervous system autoimmune disease Journal of Experimental Medicine  1996 184:2371-2384  DOI:10.1084/jem.184.6.2371  PMID:8976191
    • Oldstone, M. B. A. Principles of viral pathogenesis Cell  1996 87:799-801  DOI:10.1016/s0092-8674(00)81987-x  PMID:8945507
    • Steinhauer, D. A., Martin, J., Lin, Y. P., Wharton, S. A., Oldstone, M. B. A., Skehel, J. J., Wiley, D. C. Studies using double mutants of the conformational transitions in influenza hemagglutinin required for its membrane fusion activity Proceedings of the National Academy of Sciences of the United States of America  1996 93:12873-12878  DOI:10.1073/pnas.93.23.12873  PMID:8917512
    • Tishon, A., Manchester, M., Scheiflinger, F., Oldstone, M. B. A. A model of measles virus-induced immunosuppression: Enhanced susceptibility of neonatal human pbls Nature Medicine  1996 2:1250-1254  DOI:10.1038/nm1196-1250  PMID:8898755
    • Waters, J. B., Oldstone, M. B. A., Hahn, K. M. Changes in the cytoplasmic structure of ctls during target cell recognition and killing Journal of Immunology  1996 157:3396-3403  PMID:8871637
    • Oldstone, M. B. A., von Herrath, M. Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and other autoimmune diseases APMIS  1996 104:689-697  DOI:10.1111/j.1699-0463.1996.tb04930.x  PMID:8980618
    • Teng, M. N., Oldstone, M. B. A., DelaTorre, J. C. Suppression of lymphocytic choriomeningitis virus-induced growth hormone deficiency syndrome by disease-negative virus variants Virology  1996 223:113-119  DOI:10.1006/viro.1996.0460  PMID:8806545
    • Hudrisier, D., Mazarguil, H., Laval, F., Oldstone, M. B. A., Gairin, J. E. Binding of viral antigens to major histocompatibility complex class i h-2d(b) molecules is controlled by dominant negative elements at peptide non-anchor residues - implications for peptide selection and presentation Journal of Biological Chemistry  1996 271:17829-17836  PMID:8663374
    • delaTorre, J. C., Mallory, M., Brot, M., Gold, L., Koob, G., Oldstone, M. B. A., Masliah, E. Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells Virology  1996 220:508-515  DOI:10.1006/viro.1996.0340  PMID:8661403
    • Guidotti, L. G., Borrow, P., Hobbs, M. V., Matzke, B., Gresser, I., Oldstone, M. B. A., Chisari, F. V. Viral cross talk: Intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver Proceedings of the National Academy of Sciences of the United States of America  1996 93:4589-4594  DOI:10.1073/pnas.93.10.4589  PMID:8643448
    • Borrow, P., Tishon, A., Lee, S., Xu, J. C., Grewal, I. S., Oldstone, M. B. A., Flavell, R. A. Cd40l-deficient mice show deficits in antiviral immunity and have an impaired memory cd8(+) ctl response Journal of Experimental Medicine  1996 183:2129-2142  DOI:10.1084/jem.183.5.2129  PMID:8642323
    • Lee, M. S., Sawyer, S., Arnush, M., Krahl, T., vonHerrath, M., Oldstone, M. B. A., Sarvetnick, N. Transforming growth factor-beta fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice Transplantation  1996 61:1112-1113  PMID:8623195
    • Dockter, J., Evans, C. F., Tishon, A., Oldstone, M. B. A. Competitive selection in vivo by a cell for one variant over another: Implications for rna virus quasispecies in vivo Journal of Virology  1996 70:1799-1803  PMID:8627703  PMCID:PMC190006
    • Eddleston, M., de la Torre, J. C., Campbell, I. L., Oldstone, M. B. The M22 antibody identifies highly activated reactive astrocytes responding to central nervous system disease Acta Neuropathologica  1996 91:298-308  DOI:10.1007/s004010050429  PMID:8834543
    • delaTorre, J. C., Oldstone, M. B. A. Anatomy of viral persistence: mechanisms of persistence and associated disease Advances in Virus Research  1996 46:311-343  DOI:10.1016/S0065-3527(08)60075-5  PMID:8824703
    • von Herrath, M. G., Yokoyama, M., Dockter, J., Oldstone, M. B. A., Whitton, J. L. Cd4-deficient mice have reduced levels of memory cytotoxic t lymphocytes after immunization and show diminished resistance to subsequent virus challenge Journal of Virology  1996 70:1072-1079  PMID:8551565  PMCID:PMC189913
    • von Herrath, M. G., Dyrberg, T., Oldstone, M. B. A. Oral insulin treatment suppresses virus-induced antigen-specific destruction of beta cells and prevents autoimmune diabetes in transgenic mice Journal of Clinical Investigation  1996 98:1324-1331  DOI:10.1172/jci118919  PMID:8823297
    • von Herrath, M. G., Evans, C. F., Horwitz, M. S., Oldstone, M. B. A. Using transgenic mouse models to dissect the pathogenesis of virus-induced autoimmune disorders of the islets of langerhans and the central nervous system Immunological Reviews  1996 152:111-143  PMID:8930670
    • von Herrath, M. G., Oldstone, M. B. A. Virus-induced autoimmune disease Current Opinion in Immunology  1996 8:878-885  DOI:10.1016/S0952-7915(96)80019-7  PMID:8994870
    • Oldstone, M. B. A., vonHerrath, M., Evans, C. F., Horwitz, M. S. Virus-induced autoimmune disease: transgenic approach to mimic insulin-dependent diabetes mellitus and multiple sclerosis Current Topics in Microbiology and Immunology  1996 206:67-83  DOI:10.1007/978-3-642-85208-4_5  PMID:8608726
    • Oldstone, M. B. A., Lewicki, H., Borrow, P., Hudrisier, D., Gairin, J. E. Discriminated selection among viral peptides with the appropriate anchor residues - implications for the size of the cytotoxic t-lymphocyte repertoire and control of viral-infection Journal of Virology  1995 69:7423-7429  PMID:7494247  PMCID:PMC189679
    • Rall, G. F., Mucke, L., Oldstone, M. B. A. Consequences of cytotoxic T lymphocyte interaction with major histocompatibility complex class I-expressing neurons in vivo Journal of Experimental Medicine  1995 182:1201-1212  DOI:10.1084/jem.182.5.1201  PMID:7595191  PMCID:PMC2192211
    • Race, R. E., Priola, S. A., Bessen, R. A., Ernst, D., Dockter, J., Rall, G. F., Mucke, L., Chesebro, B., Oldstone, M. B. A. Neuron-specific expression of a hamster prion protein minigene in transgenic mice induces susceptibility to hamster scrapie agent Neuron  1995 15:1183-1191  DOI:10.1016/0896-6273(95)90105-1  PMID:7576660
    • Vonherrath, M. G., Oldstone, M. B. A. Role of viruses in the loss of tolerance to self-antigens and in autoimmune-diseases Trends in Microbiology  1995 3:424-430  DOI:10.1016/s0966-842x(00)88995-7  PMID:8574515
    • Tishon, A., Lewicki, H., Rall, G., Vonherrath, M., Oldstone, M. B. A. An essential role for type-1 interferon-gamma in terminating persistent viral-infection Virology  1995 212:244-250  DOI:10.1006/viro.1995.1477  PMID:7676639
    • Lewicki, H. A., Vonherrath, M. G., Evans, C. F., Whitton, J. L., Oldstone, M. B. A. CTL escape viral variants. II. Biologic activity in vivo Virology  1995 211:443-450  DOI:10.1006/viro.1995.1426  PMID:7645248
    • Hudrisier, D., Mazarguil, H., Oldstone, M. B. A., Gairin, J. E. Relative implication of peptide residues in binding to major histocompatibility complex class-i h-2d(b) - application to the design of high-affinity, allele-specific peptides Molecular Immunology  1995 32:895-907  DOI:10.1016/0161-5890(95)00043-e  PMID:7565816
    • Lewicki, H., Tishon, A., Borrow, P., Evans, C. F., Gairin, J. E., Hahn, K. M., Jewell, D. A., Wilson, I. A., Oldstone, M. B. A. Ctl escape viral variants .1. Generation and molecular characterization Virology  1995 210:29-40  DOI:10.1006/viro.1995.1314  PMID:7793078
    • Vonherrath, M., Oldstone, M. B. A., Fox, H. S. Simian immunodeficiency virus (siv)-specific ctl in cerebrospinal-fluid and brains of siv-infected rhesus macaques Journal of Immunology  1995 154:5582-5589  PMID:7730657
    • Gairin, J. E., Mazarguil, H., Hudrisier, D., Oldstone, M. B. A. Optimal lymphocytic choriomeningitis virus sequences restricted by h-2d(b) major histocompatibility complex class-i molecules and presented to cytotoxic t-lymphocytes Journal of Virology  1995 69:2297-2305  PMID:7533855  PMCID:PMC188900
    • Manchester, M., Valsamakis, A., Kaufman, R., Liszewski, M. K., Alvarez, J., Atkinson, J. P., Lublin, D. M., Oldstone, M. B. A. Measles-virus and c3 binding-sites are distinct on membrane cofactor protein (cd46) Proceedings of the National Academy of Sciences of the United States of America  1995 92:2303-2307  DOI:10.1073/pnas.92.6.2303  PMID:7534417
    • Vonherrath, M. G., Allison, J., Miller, Jfap, Oldstone, M. B. A. Focal expression of interleukin-2 does not break unresponsiveness to self (viral) antigen expressed in beta-cells but enhances development of autoimmune-disease (diabetes) after initiation of an anti-self immune-response Journal of Clinical Investigation  1995 95:477-485  DOI:10.1172/jci117688  PMID:7860729
    • Lee, M. S., Vonherrath, M., Reiser, H., Oldstone, M. B. A., Sarvetnick, N. Sensitization to self (virus) antigen by in-situ expression of murine interferon-gamma Journal of Clinical Investigation  1995 95:486-492  DOI:10.1172/jci117689  PMID:7860730
    • Borrow, P., Evans, C. F., Oldstone, M. B. A. Virus-induced immunosuppression - immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression Journal of Virology  1995 69:1059-1070  PMID:7815484  PMCID:PMC188677
    • von Herrath, M. G., Guerder, S., Lewicki, H., Flavell, R. A., Oldstone, M. B. A. Coexpression of b7-1 and viral (''self'') transgenes in pancreatic beta cells can break peripheral ignorance and lead to spontaneous autoimmune diabetes Immunity  1995 3:727-738  DOI:10.1016/1074-7613(95)90062-4  PMID:8777718
    • Borrow, P., Oldstone, M. B. A. Measles-virus - mononuclear cell-interactions Measles Virus  1995 191:85-100  PMID:7789164
    • Ada, G., Albrecht, P., Beale, J., Bellini, W. J., Bloom, B., Choppin, P. W., Chu, C. M., Clements, C. J., Cutts, F., Dequadros, C., Gellin, B. G., Griffin, D. E., et al. A Bellagio consensus. Children's Vaccine Initiative Ad Hoc Committe on an investment strategy for measles control Journal of Infectious Diseases  1994 170:S63-S66  DOI:10.1093/infdis/170.Supplement_1.S63  PMID:7930755
    • Vonherrath, M. G., Dockter, J., Nerenberg, M., Gairin, J. E., Oldstone, M. B. A. Thymic selection and adaptability of cytotoxic t-lymphocyte responses in transgenic mice expressing a viral protein in the thymus Journal of Experimental Medicine  1994 180:1901-1910  DOI:10.1084/jem.180.5.1901  PMID:7525843
    • Evans, C. F., Borrow, P., Delatorre, J. C., Oldstone, M. B. A. Virus-induced immunosuppression - kinetic-analysis of the selection of a mutation associated with viral persistence Journal of Virology  1994 68:7367-7373  PMID:7933120  PMCID:PMC237179
    • Gold, L. H., Brot, M. D., Polis, I., Schroeder, R., Tishon, A., Delatorre, J. C., Oldstone, M. B. A., Koob, G. F. Behavioral-effects of persistent lymphocytic choriomeningitis virus-infection in mice Behavioral and Neural Biology  1994 62:100-109  DOI:10.1016/s0163-1047(05)80031-7  PMID:7993301
    • Borrow, P., Lewicki, H., Hahn, B. H., Shaw, G. M., Oldstone, M. B. A. Virus-specific cd8+ cytotoxic t-lymphocyte activity associated with control of viremia in primary human-immunodeficiency-virus type-1 infection Journal of Virology  1994 68:6103-6110  PMID:8057491  PMCID:PMC237022
    • Campbell, I. L., Hobbs, M. V., Dockter, J., Oldstone, M. B. A., Allison, J. Islet inflammation and hyperplasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice American Journal of Pathology  1994 145:157-166  PMID:8030746  PMCID:PMC1887304
    • Rall, G. F., Mucke, L., Nerenberg, M., Oldstone, M. B. A. A transgenic mouse model to assess the interaction of cytotoxic t-lymphocytes with virally infected, class-i mhc-expressing astrocytes Journal of Neuroimmunology  1994 52:61-68  DOI:10.1016/0165-5728(94)90163-5  PMID:8207120
    • Hahn, K., Debiasio, R., Tishon, A., Lewicki, H., Gairin, J. E., Larocca, G., Taylor, D. L., Oldstone, M. Antigen presentation and cytotoxic t-lymphocyte killing studied in individual, living cells Virology  1994 201:330-340  DOI:10.1006/viro.1994.1298  PMID:8184542
    • Vonherrath, M. G., Dockter, J., Oldstone, M. B. A. How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model Immunity  1994 1:231-242  DOI:10.1016/1074-7613(94)90101-5  PMID:7889411
    • Doherty, P. C., Hou, S., Evans, C. F., Whitton, J. L., Oldstone, M. B. A., Blackman, M. A. Limiting the available t-cell receptor repertoire modifies acute lymphocytic choriomeningitis virus-induced immunopathology Journal of Neuroimmunology  1994 51:147-152  DOI:10.1016/0165-5728(94)90076-0  PMID:8182114
    • Campbell, I. L., Eddleston, M., Kemper, P., Oldstone, M. B. A., Hobbs, M. V. Activation of cerebral cytokine gene-expression and its correlation with onset of reactive astrocyte and acute-phase response gene-expression in scrapie Journal of Virology  1994 68:2383-2387  PMID:8139024  PMCID:PMC236715
    • Manchester, M., Liszewski, M. K., Atkinson, J. P., Oldstone, M. B. A. Multiple isoforms of cd46 (membrane cofactor protein) serve as receptors for measles-virus Proceedings of the National Academy of Sciences of the United States of America  1994 91:2161-2165  DOI:10.1073/pnas.91.6.2161  PMID:8134365
    • Lee, M. S., Wogensen, L., Shizuru, J., Oldstone, M. B. A., Sarvetnick, N. Pancreatic-islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction Journal of Clinical Investigation  1994 93:1332-1338  DOI:10.1172/jci117092  PMID:8132775
    • Buesagomez, J., Delatorre, J. C., Dyrberg, T., Landinolsson, M., Mauseth, R. S., Lernmark, A., Oldstone, M. B. A. Failure to detect genomic viral sequences in pancreatic tissues from 2 children with acute-onset diabetes-mellitus Journal of Medical Virology  1994 42:193-197  DOI:10.1002/jmv.1890420217  PMID:8158114
    • Campbell, I. L., Hobbs, M. V., Kemper, P., Oldstone, M. B. A. Cerebral expression of multiple cytokine genes in mice with lymphocytic choriomeningitis Journal of Immunology  1994 152:716-723  PMID:8283046
    • Borrow, P., Oldstone, M. B. A. Mechanism of lymphocytic choriomeningitis virus entry into cells Virology  1994 198:1-9  DOI:10.1006/viro.1994.1001  PMID:8259643
    • Horwitz, M. S., Yanagi, Y., Oldstone, M. B. A. T-cell receptors from virus-specific cytotoxic T lymphocytes recognizing a single immunodominant nine-amino-acid viral epitope show marked diversity Journal of Virology  1994 68:352-357  PMID:7504738  PMCID:PMC236295
    • Evans, C. F., Rall, G. F., Killeen, N., Littman, D., Oldstone, M. B. A. Cd2-deficient mice generate virus-specific cytotoxic t-lymphocytes upon infection with lymphocytic choriomeningitis virus Journal of Immunology  1993 151:6259-6264  PMID:7902375
    • Delatorre, J. C., Rall, G., Oldstone, C., Sanna, P. P., Borrow, P., Oldstone, M. B. A. Replication of lymphocytic choriomeningitis virus is restricted in terminally differentiated neurons Journal of Virology  1993 67:7350-7359  PMID:8230458  PMCID:PMC238199
    • Tishon, A., Eddleston, M., Delatorre, J. C., Oldstone, M. B. A. Cytotoxic T-lymphocytes cleanse viral gene-products from individually infected neurons and lymphocytes in mice persistently infected with lymphocytic choriomeningitis virus Virology  1993 197:463-467  DOI:10.1006/viro.1993.1613  PMID:8212586
    • Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P., Inglis, J. D., Oldstone, M. B. A., Mucke, L. Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin-6 Proceedings of the National Academy of Sciences of the United States of America  1993 90:10061-10065  DOI:10.1073/pnas.90.21.10061  PMID:7694279  PMCID:PMC47713
    • Oldstone, M. B. A. Viruses and diseases of the 21st-century American Journal of Pathology  1993 143:1241-1249  PMID:8238240  PMCID:PMC1887167
    • Eddleston, M., Delatorre, J. C., Xu, J. Y., Dorfman, N., Notkins, A., Zollapazner, S., Oldstone, M. B. A. Molecular mimicry accompanying HIV-1 infection - human monoclonal-antibodies that bind to gp41 and to astrocytes AIDS Research and Human Retroviruses  1993 9:939-944  DOI:10.1089/aid.1993.9.939  PMID:7506553
    • Laufer, T. M., Vonherrath, M. G., Grusby, M. J., Oldstone, M. B. A., Glimcher, L. H. Autoimmune diabetes can be induced in transgenic major histocompatibility complex class-ii-deficient mice Journal of Experimental Medicine  1993 178:589-596  DOI:10.1084/jem.178.2.589  PMID:8101862
    • Tishon, A., Borrow, P., Evans, C., Oldstone, M. B. A. Virus-induced immunosuppression .1. Age at infection relates to a selective or generalized defect Virology  1993 195:397-405  DOI:10.1006/viro.1993.1389  PMID:8393233
    • Eddleston, M., Delatorre, J. C., Oldstone, M. B. A., Loskutoff, D. J., Edgington, T. S., Mackman, N. Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis Journal of Clinical Investigation  1993 92:349-358  DOI:10.1172/jci116573  PMID:8326003  PMCID:PMC293611
    • Oldstone, M. B. A., Southern, P. J. Trafficking of activated cytotoxic t-lymphocytes into the central-nervous-system - use of a transgenic model Journal of Neuroimmunology  1993 46:25-32  DOI:10.1016/0165-5728(93)90230-v  PMID:8360331
    • Oldstone, M. B. A., Tishon, A., Eddleston, M., Delatorre, J. C., McKee, T., Whitton, J. L. Vaccination to prevent persistent viral infection Journal of Virology  1993 67:4372-4378  PMID:8510226  PMCID:PMC237809
    • Gairin, J. E., Oldstone, M. B. A. Virus and cytotoxic t-lymphocytes - crucial role of viral peptide secondary structure in major histocompatibility complex class-i interactions Journal of Virology  1993 67:2903-2907  PMID:7682632  PMCID:PMC237616
    • Whitton, J. L., Sheng, N., Oldstone, M. B. A., McKee, T. A. A string-of-beads vaccine, comprising linked minigenes, confers protection from lethal-dose virus challenge Journal of Virology  1993 67:348-352  PMID:7677954  PMCID:PMC237369
    • Oldstone, M. B. A., Rall, G. F. Mechanism and consequence of viral persistence in cells of the immune-system and neurons Intervirology  1993 35:116-121  PMID:8407238
    • Borrow, P., Oldstone, M. B. A. Characterization of lymphocytic choriomeningitis virus-binding protein(s) - a candidate cellular receptor for the virus Journal of Virology  1992 66:7270-7281  PMID:1331520  PMCID:PMC240431
    • Gairin, J. E., Oldstone, M. B. A. Design of high-affinity major histocompatibility complex-specific antagonist peptides that inhibit cytotoxic lymphocyte-t activity - implications for control of viral disease Journal of Virology  1992 66:6755-6762  PMID:1383569  PMCID:PMC240172
    • Lohr, M., Bergstrome, B., Maekawa, R., Oldstone, M. B. A., Kloppel, G. Human cytomegalovirus in the pancreas of patients with type-2 diabetes - is there a relation to clinical-features, messenger-rna and protein expression of insulin, somatostatin, and mhc class-ii Virchows Archiv A-Pathological Anatomy and Histopathology  1992 421:371-378  DOI:10.1007/bf01606908  PMID:1360719
    • Lewicki, H., McKee, T. A., Tishon, A., Salvato, M., Whitton, J. L., Oldstone, M. B. A. Novel lcmv-specific h-2k restricted ctl clones recognize internal viral gene-products and cause cns disease Journal of Neuroimmunology  1992 41:15-20  DOI:10.1016/0165-5728(92)90190-v  PMID:1281166
    • Delatorre, J. C., Oldstone, M. B. A. Selective disruption of growth-hormone transcription machinery by viral-infection Proceedings of the National Academy of Sciences of the United States of America  1992 89:9939-9943  PMID:1409723  PMCID:PMC50249
    • Joly, E., Oldstone, M. B. A. Neuronal cells are deficient in loading peptides onto mhc class-i molecules Neuron  1992 8:1185-1190  DOI:10.1016/0896-6273(92)90138-4  PMID:1610569
    • Wirth, J. J., Amalfitano, A., Gross, R., Oldstone, M. B. A., Fluck, M. M. Organ-specific and age-specific replication of polyomavirus in mice Journal of Virology  1992 66:3278-3286  PMID:1316447  PMCID:PMC241105
    • Oldstone, M. B. A., Tishon, A., Geckeler, R., Lewicki, H., Whitton, J. L. A common antiviral cytotoxic lymphocyte-t epitope for diverse major histocompatibility complex haplotypes - implications for vaccination Proceedings of the National Academy of Sciences of the United States of America  1992 89:2752-2755  DOI:10.1073/pnas.89.7.2752  PMID:1372990
    • Yanagi, Y., Tishon, A., Lewicki, H., Cubitt, B. A., Oldstone, M. B. A. Diversity of T-cell receptors in virus-specific cytotoxic T lymphocytes recognizing three distinct viral epitopes restricted by a single major histocompatibility complex molecule Journal of Virology  1992 66:2527-2531  PMID:1372370  PMCID:PMC289052
    • Yanagi, Y., Cubitt, B. A., Oldstone, M. B. A. Measles-virus inhibits mitogen-induced t-cell proliferation but does not directly perturb the t-cell activation process inside the cell Virology  1992 187:280-289  DOI:10.1016/0042-6822(92)90316-h  PMID:1736530
    • Mucke, L., Oldstone, M. B. A. The expression of major histocompatibility complex (mhc) class-i antigens in the brain differs markedly in acute and persistent infections with lymphocytic choriomeningitis virus (lcmv) Journal of Neuroimmunology  1992 36:193-198  DOI:10.1016/0165-5728(92)90050-u  PMID:1732281
    • Littaua, R. A., Oldstone, M. B. A., Takeda, A., Ennis, F. A. A cd4+ cytotoxic lymphocyte-t clone to a conserved epitope on human-immunodeficiency-virus type-1 p24 - cytotoxic activity and secretion of interleukin-2 and interleukin-6 Journal of Virology  1992 66:608-611  PMID:1370094
    • Oldstone, M. B. A. Molecular anatomy of viral persistence Journal of Virology  1991 65:6381-6386  PMID:1719227  PMCID:PMC250674
    • Tishon, A., Salmi, A., Ahmed, R., Oldstone, M. B. A. Role of viral strains and host genes in determining levels of immune-complexes in a model system - implications for hiv-infection AIDS Research and Human Retroviruses  1991 7:963-969  DOI:10.1089/aid.1991.7.963  PMID:1812945
    • Delatorre, J. C., Borrow, P., Oldstone, M. B. A. Viral persistence and disease - cytopathology in the absence of cytolysis British Medical Bulletin  1991 47:838-851  PMID:1794088
    • Joly, E., Mucke, L., Oldstone, M. B. A. Viral persistence in neurons explained by lack of major histocompatibility class-1 expression Science  1991 253:1283-1285  DOI:10.1126/science.1891717  PMID:1891717
    • Littaua, R. A., Oldstone, M. B. A., Takeda, A., Debouck, C., Wong, J. T., Tuazon, C. U., Moss, B., Kievits, F., Ennis, F. A. An hla-c-restricted cd8+ cytotoxic lymphocyte-t clone recognizes a highly conserved epitope on human-immunodeficiency-virus type-1 gag Journal of Virology  1991 65:4051-4056  PMID:1712857  PMCID:PMC248836
    • Borrow, P., Tishon, A., Oldstone, M. B. A. Infection of lymphocytes by a virus that aborts cytotoxic lymphocyte-t activity and establishes persistent infection Journal of Experimental Medicine  1991 174:203-212  DOI:10.1084/jem.174.1.203  PMID:1905339
    • Joly, E., Oldstone, M. B. A. Manufacture of a functional cdna for the h-2db molecule using a retroviral shuttle vector Immunogenetics  1991 34:62-65  DOI:10.1007/bf00212315  PMID:1713192
    • Gairin, J. E., Joly, E., Oldstone, M. B. A. Persistent infection with lymphocytic choriomeningitis virus enhances expression of mhc class-i glycoprotein on cultured mouse-brain endothelial-cells Journal of Immunology  1991 146:3953-3957  PMID:2033264
    • Mucke, L., Oldstone, M. B. A., Morris, J. C., Nerenberg, M. I. Rapid activation of astrocyte-specific expression of gfap-lacz transgene by focal injury New Biologist  1991 3:465-474  PMID:1883812
    • Oldstone, M. B. A., Nerenberg, M., Southern, P., Price, J., Lewicki, H. Virus-infection triggers insulin-dependent diabetes-mellitus in a transgenic model - role of anti-self (virus) immune-response Cell  1991 65:319-331  DOI:10.1016/0092-8674(91)90165-u  PMID:1901765
    • Oldstone, M. B. A., Tishon, A., Lewicki, H., Dyson, H. J., Feher, V. A., Assamunt, N., Wright, P. E. Mapping the anatomy of the immunodominant domain of the human immunodeficiency virus gp41 transmembrane protein: peptide conformation analysis using monoclonal antibodies and proton nuclear magnetic resonance spectroscopy Journal of Virology  1991 65:1727-1734  PMID:2002540  PMCID:PMC239977
    • Salvato, M., Borrow, P., Shimomaye, E., Oldstone, M. B. A. Molecular basis of viral persistence: a single amino acid change in the glycoprotein of lymphocytic choriomeningitis virus is associated with suppression of the antiviral cytotoxic T-lymphocyte response and establishment of persistence Journal of Virology  1991 65:1863-1869  PMID:1840619  PMCID:PMC239996
    • Yamada, M., Zurbriggen, A., Oldstone, M. B. A., Fujinami, R. S. Common immunological determinant between human-immunodeficiency-virus type-1 gp41 and astrocytes Journal of Virology  1991 65:1370-1376  PMID:1704927  PMCID:PMC239914
    • Joly, E., Oldstone, M. B. A. Generation of a functional cdna-encoding the ldh2 class-i molecule by using a single-ltr retroviral shuttle vector Gene  1991 97:213-221  DOI:10.1016/0378-1119(91)90054-f  PMID:1705528
    • Yanagi, Y., Maekawa, R., Cook, T., Kanagawa, O., Oldstone, M. B. A. Restricted v-segment usage in t-cell receptors from cytotoxic lymphocytes-t specific for a major epitope of lymphocytic choriomeningitis virus Journal of Virology  1990 64:5919-5926  PMID:1700830  PMCID:PMC248763
    • Tishon, A., Oldstone, M. B. A. Perturbation of differentiated functions during viral infection in vivo. In vivo relationship of host genes and lymphocytic choriomeningitis virus to growth hormone deficiency American Journal of Pathology  1990 137:965-969  PMID:2221020  PMCID:PMC1877543
    • Klavinskis, L. S., Whitton, J. L., Joly, E., Oldstone, M. B. A. Vaccination and protection from a lethal viral infection: identification, incorporation, and use of a cytotoxic T lymphocyte glycoprotein epitope Virology  1990 178:393-400  DOI:10.1016/0042-6822(90)90336-p  PMID:1699348
    • Lohr, J. M., Oldstone, M. B. A. Detection of cytomegalovirus nucleic-acid sequences in pancreas in type-2 diabetes Lancet  1990 336:644-648  DOI:10.1016/0140-6736(90)92145-8  PMID:1975850
    • Oldstone, M. B. A. Viruses as therapeutic agents .1. Treatment of nonobese insulin-dependent diabetes mice with virus prevents insulin-dependent diabetes-mellitus while maintaining general immune competence Journal of Experimental Medicine  1990 171:2077-2089  DOI:10.1084/jem.171.6.2077  PMID:1972180
    • Oldstone, M. B. A., Ahmed, R., Salvato, M. Viruses as therapeutic agents .2. Viral reassortants map prevention of insulin-dependent diabetes-mellitus to the small rna of lymphocytic choriomeningitis virus Journal of Experimental Medicine  1990 171:2091-2100  DOI:10.1084/jem.171.6.2091  PMID:2191074
    • Oldstone, M. B. A. Viral persistence and immune dysfunction Hospital Practice  1990 25:81-85, 88, 91 passim  PMID:2110177
    • Lohr, J. M., Nelson, J. A., Oldstone, M. B. A. Is herpes-simplex virus associated with peptic-ulcer disease Journal of Virology  1990 64:2168-2174  PMID:2157877  PMCID:PMC249375
    • Oldstone, M. B. A., Tishon, A., Schwimmbeck, P. L., Shyp, S., Lewicki, H., Dyrberg, T. Cytotoxic lymphocytes-t do not control lymphocytic choriomeningitis virus-infection of bb diabetes-prone rats Journal of General Virology  1990 71:785-791  DOI:10.1099/0022-1317-71-4-785  PMID:2324708
    • Shyp, S., Tishon, A., Oldstone, M. B. A. Inhibition of diabetes in bb rats by virus-infection .2. Effect of virus-infection on the immune-response to nonviral and viral-antigens Immunology  1990 69:501-507  PMID:2335372  PMCID:PMC1385619
    • Dyrberg, T., Petersen, J. S., Oldstone, M. B. A. Immunological cross-reactivity between mimicking epitopes on a virus protein and a human autoantigen depends on a single amino-acid residue Clinical Immunology and Immunopathology  1990 54:290-297  DOI:10.1016/0090-1229(90)90090-d  PMID:1688524
    • Lathey, J. L., Agosti, J. M., Nelson, J. A., Corey, L., Gregory, S. A., Morrissey, J. H., Edgington, T. S., Oldstone, M. B. A. A selective defect in tissue factor messenger-rna expression in monocytes from aids patients Clinical Immunology and Immunopathology  1990 54:1-13  DOI:10.1016/0090-1229(90)90001-7  PMID:2293902
    • Gnann, J. W., Oldstone, M. B. A. Using synthetic peptide reagents to distinguish infections caused by different hiv strains Current Topics in Microbiology and Immunology  1990 160:131-143  PMID:2191839
    • Klavinskis, L. S., Geckeler, R., Oldstone, M. B. A. Cytotoxic T lymphocyte control of acute lymphocytic choriomeningitis virus infection: interferon gamma, but not tumour necrosis factor alpha, displays antiviral activity in vivo Journal of General Virology  1989 70:3317-3325  DOI:10.1099/0022-1317-70-12-3317  PMID:2514255
    • Whitton, J. L., Tishon, A., Lewicki, H., Gebhard, J., Cook, T., Salvato, M., Joly, E., Oldstone, M. B. A. Molecular analyses of a 5-amino-acid cyto-toxic lymphocyte-t (ctl) epitope - an immunodominant region which induces nonreciprocal ctl cross-reactivity Journal of Virology  1989 63:4303-4310  PMID:2476570  PMCID:PMC251046
    • Schwimmbeck, P. L., Dyrberg, T., Drachman, D. B., Oldstone, M. B. A. Molecular mimicry and myasthenia-gravis - an autoantigenic site of the acetylcholine-receptor alpha-subunit that has biologic activity and reacts immunochemically with herpes-simplex virus Journal of Clinical Investigation  1989 84:1174-1180  DOI:10.1172/jci114282  PMID:2551924
    • Klavinskis, L. S., Whitton, J. L., Oldstone, M. B. A. Molecularly engineered vaccine which expresses an immunodominant t-cell epitope induces cyto-toxic lymphocytes-t that confer protection from lethal virus-infection Journal of Virology  1989 63:4311-4316  PMID:2476571  PMCID:PMC251047
    • Klavinskis, L. S., Tishon, A., Oldstone, M. B. A. Efficiency and effectiveness of cloned virus-specific cytotoxic T lymphocytes in vivo Journal of Immunology  1989 143:2013-2016  PMID:2476492
    • Whitton, J. L., Oldstone, M. B. A. Class-i mhc can present an endogenous peptide to cyto-toxic lymphocytes-t Journal of Experimental Medicine  1989 170:1033-1038  DOI:10.1084/jem.170.3.1033  PMID:2475568
    • Chang, C. P., Vesole, D. H., Nelson, J., Oldstone, M. B. A., Stinski, M. F. Identification and expression of a human cytomegalo-virus early glycoprotein Journal of Virology  1989 63:3330-3337  PMID:2545908  PMCID:PMC250906
    • Oldstone, M. B. A. Viral alteration of cell function Scientific American  1989 261:42-48  PMID:2569234
    • Oldstone, M. B. A. Virus-induced autoimmunity: molecular mimicry as a route to autoimmune disease Journal of Autoimmunity  1989 2:187-194  DOI:10.1016/0896-8411(89)90130-3  PMID:2673272
    • Joly, E., Salvato, M., Whitton, J. L., Oldstone, M. B. A. Polymorphism of cyto-toxic lymphocyte-t clones that recognize a defined 9-amino-acid immunodominant domain of lymphocytic choriomeningitis virus glycoprotein Journal of Virology  1989 63:1845-1851  PMID:2467990  PMCID:PMC250594
    • Husby, G., Tsuchiya, N., Schwimmbeck, P. L., Keat, A., Pahle, J. A., Oldstone, M. B. A., Williams, R. C. Cross-reactive epitope with klebsiella-pneumoniae nitrogenase in articular tissue of hla-b27+ patients with ankylosing-spondylitis Arthritis and Rheumatism  1989 32:437-445  DOI:10.1002/anr.1780320413  PMID:2468338
    • Salvato, M., Shimomaye, E., Oldstone, M. B. A. The primary structure of the lymphocytic choriomeningitis virus l-gene encodes a putative rna-polymerase Virology  1989 169:377-384  DOI:10.1016/0042-6822(89)90163-3  PMID:2705303
    • McChesney, M. B., Fujinami, R. S., Lerche, N. W., Marx, P. A., Oldstone, M. B. A. Virus-induced immunosuppression - infection of peripheral-blood mononuclear-cells and suppression of immunoglobulin-synthesis during natural measles-virus infection of rhesus-monkeys Journal of Infectious Diseases  1989 159:757-760  PMID:2784472
    • Oldstone, M. B. A. Viruses can cause disease in the absence of morphological evidence of cell injury - implication for uncovering new diseases in the future Journal of Infectious Diseases  1989 159:384-389  PMID:2644376
    • Oldstone, M. B. A. Viral persistence Cell  1989 56:517-520  DOI:10.1016/0092-8674(89)90573-4  PMID:2645053
    • Schrier, R. D., Gnann, J. W., Landes, R., Lockshin, C., Richman, D., McCutchan, A., Kennedy, C., Oldstone, M. B. A., Nelson, J. A. T-cell recognition of hiv synthetic peptides in a natural infection Journal of Immunology  1989 142:1166-1176  PMID:2783706
    • Klavinskis, L. S., Oldstone, M. B. A. Lymphocytic choriomeningitis virus selectively alters differentiated but not housekeeping functions - block in expression of growth-hormone gene is at the level of transcriptional initiation Virology  1989 168:232-235  DOI:10.1016/0042-6822(89)90262-6  PMID:2916325
    • Gnann, J. W., Smith, L. L., Oldstone, M. B. A. Custom-designed synthetic peptide immunoassays for distinguishing hiv type-1 and type-2 infections Methods in Enzymology  1989 178:693-714  PMID:2481220
    • Young, L. H. Y., Klavinskis, L. S., Oldstone, M. B. A., Young, J. D. E. In vivo expression of perforin by CD8+ lymphocytes during an acute viral infection Journal of Experimental Medicine  1989 169:2159-2171  DOI:10.1084/jem.169.6.2159  PMID:2471775  PMCID:PMC2189355
    • Schwimmbeck, P. L., Oldstone, M. B. A. Klebsiella pneumoniae and hla-b27-associated diseases of reiters-syndrome and ankylosing-spondylitis Current Topics in Microbiology and Immunology  1989 145:45-56  PMID:2680296
    • Oldstone, M. B. A. Molecular mimicry as a mechanism for the cause and as a probe uncovering etiologic agent(s) of autoimmune-disease Current Topics in Microbiology and Immunology  1989 145:127-135  PMID:2805785
    • Fujinami, R. S., Oldstone, M. B. A. Molecular mimicry as a mechanism for virus-induced autoimmunity Immunologic Research  1989 8:3-15  DOI:10.1007/bf02918552  PMID:2647867
    • McChesney, M. B., Oldstone, M. B. A. Virus-induced immunosuppression: infections with measles virus and human immunodeficiency virus Advances in Immunology  1989 45:335-380  DOI:10.1016/S0065-2776(08)60696-3  PMID:2665441
    • Lipkin, W. I., Villarreal, L. P., Oldstone, M. B. A. Whole animal section insitu hybridization and protein blotting - new tools in molecular analysis of animal-models for human-disease Current Topics in Microbiology and Immunology  1989 143:33-54  PMID:2670459
    • Schwimmbeck, P. L., Oldstone, M. B. A. Molecular mimicry between human-leukocyte antigen b27 and klebsiella - consequences for spondyloarthropathies American Journal of Medicine  1988 85:51-53  DOI:10.1016/0002-9343(88)90385-3
    • Lipkin, W. I., Carbone, K. M., Wilson, M. C., Duchala, C. S., Narayan, O., Oldstone, M. B. A. Neurotransmitter abnormalities in borna disease Brain Research  1988 475:366-370  DOI:10.1016/0006-8993(88)90627-0  PMID:2905625
    • Lathey, J. L., Oldstone, M. B. A. Weight-loss in obese mice persistently infected with lymphocytic choriomeningitis virus is not associated with elevated tumor necrosis factor cachectin activity in peritoneal-macrophages American Journal of Pathology  1988 132:586-592  PMID:3414785  PMCID:PMC1880743
    • Schrier, R. D., Gnann, J. W., Langlois, A. J., Shriver, K., Nelson, J. A., Oldstone, M. B. A. B- and T-lymphocyte responses to an immunodominant epitope of human immunodeficiency virus Journal of Virology  1988 62:2531-2536  PMID:3260630  PMCID:PMC253681
    • Oldstone, M. B. A., Whitton, J. L., Lewicki, H., Tishon, A. Fine dissection of a 9 amino-acid glycoprotein epitope, a major determinant recognized by lymphocytic choriomeningitis virus-specific class-i-restricted h-2db cyto-toxic lymphocytes-t Journal of Experimental Medicine  1988 168:559-570  DOI:10.1084/jem.168.2.559  PMID:2457647
    • Gnann, J. W., Ahlmen, J., Svalander, C., Olding, L., Oldstone, M. B. A., Nelson, J. A. Inflammatory cells in transplanted kidneys are infected by human cytomegalo-virus American Journal of Pathology  1988 132:239-248  PMID:2840830  PMCID:PMC1880719
    • Nelson, J. A., Reynoldskohler, C., Oldstone, M. B. A., Wiley, C. A. Hiv and hcmv coinfect brain-cells in patients with aids Virology  1988 165:286-290  DOI:10.1016/0042-6822(88)90685-x  PMID:2838967
    • Oldstone, M. B. A., Salvato, M., Tishon, A., Lewicki, H. Virus lymphocyte interactions .3. Biologic parameters of a virus variant that fails to generate ctl and establishes persistent infection in immunocompetent hosts Virology  1988 164:507-516  DOI:10.1016/0042-6822(88)90565-x  PMID:2967012
    • Salvato, M., Shimomaye, E., Southern, P., Oldstone, M. B. A. Virus lymphocyte interactions .4. Molecular characterization of lcmv armstrong (ctl+) small genomic segment and that of its variant, clone-13 (ctl-) Virology  1988 164:517-522  DOI:10.1016/0042-6822(88)90566-1  PMID:3259346
    • Schwimmbeck, P. L., Dyrberg, T., Oldstone, M. B. A. Abrogation of diabetes in bb rats by acute virus-infection - association of viral-lymphocyte interactions Journal of Immunology  1988 140:3394-3400  PMID:3283232
    • Ahmed, R., Oldstone, M. B. A. Organ-specific selection of viral variants during chronic infection Journal of Experimental Medicine  1988 167:1719-1724  DOI:10.1084/jem.167.5.1719  PMID:3367096
    • Lipkin, W. I., Schwimmbeck, P. L., Oldstone, M. B. A. Antibody to synthetic somatostatin-28(1-12) - immunoreactivity with somatostatin in brain is dependent on orientation of immunizing peptide Journal of Histochemistry & Cytochemistry  1988 36:447-451  PMID:2450123
    • Dyrberg, T., Schwimmbeck, P. L., Oldstone, M. B. A. Inhibition of diabetes in bb rats by virus-infection Journal of Clinical Investigation  1988 81:928-931  DOI:10.1172/jci113405  PMID:3343348
    • Whitton, J. L., Gebhard, J. R., Lewicki, H., Tishon, A., Oldstone, M. B. A. Molecular definition of a major cyto-toxic lymphocyte-t epitope in the glycoprotein of lymphocytic choriomeningitis virus Journal of Virology  1988 62:687-695  PMID:2448497  PMCID:PMC253621
    • McChesney, M. B., Altman, A., Oldstone, M. B. A. Suppression of lymphocyte-t function by measles-virus is due to cell-cycle arrest in g1 Journal of Immunology  1988 140:1269-1273  PMID:2449499
    • Tishon, A., Southern, P. J., Oldstone, M. B. A. Virus-lymphocyte interactions .2. Expression of viral sequences during the course of persistent lymphocytic choriomeningitis virus-infection and their localization to the lymphocyte-l3t4 subset Journal of Immunology  1988 140:1280-1284  PMID:2963865
    • Whitton, J. L., Southern, P. J., Oldstone, M. B. A. Analyses of the cyto-toxic lymphocyte-t responses to glycoprotein and nucleoprotein components of lymphocytic choriomeningitis virus Virology  1988 162:321-327  DOI:10.1016/0042-6822(88)90471-0  PMID:3257596
    • Klavinskis, L. S., Notkins, A. L., Oldstone, M. B. A. Persistent viral-infection of the thyroid-gland - alteration of thyroid-function in the absence of tissue-injury Endocrinology  1988 122:567-575  PMID:3338413
    • Oldstone, M. B. A. Prevention of type-i diabetes in nonobese diabetic mice by virus-infection Science  1988 239:500-502  DOI:10.1126/science.3277269  PMID:3277269
    • Fujinami, R. S., Nelson, J. A., Walker, L., Oldstone, M. B. A. Sequence homology and immunological cross-reactivity of human cytomegalo-virus with hla-dr beta-chain - a means for graft-rejection and immunosuppression Journal of Virology  1988 62:100-105  PMID:2446012  PMCID:PMC250506
    • Lipkin, W. I., Battenberg, E. L. F., Bloom, F. E., Oldstone, M. B. A. Viral infection of neurons can depress neurotransmitter mRNA levels without histologic injury Brain Research  1988 451:333-339  DOI:10.1016/0006-8993(88)90779-2  PMID:2908027
    • Chen, J. H., Kono, D. H., Yong, Z., Park, M. S., Oldstone, Mmba, Yu, D. T. Y. A Yersinia-pseudotuberculosis protein which cross-reacts with HLA-B27 Journal of Immunology  1987 139:3003-3011  PMID:2444647
    • McChesney, M. B., Kehrl, J. H., Valsamakis, A., Fauci, A. S., Oldstone, M. B. A. Measles-virus infection of lymphocytes-b permits cellular activation but blocks progression through the cell-cycle Journal of Virology  1987 61:3441-3447  PMID:3499518  PMCID:PMC255940
    • Oldstone, M. B. A. Molecular mimicry and autoimmune-disease Cell  1987 50:819-820  DOI:10.1016/0092-8674(87)90507-1  PMID:3621346
    • Gnann, J. W., McCormick, J. B., Mitchell, S., Nelson, J. A., Oldstone, M. B. A. Synthetic peptide immunoassay distinguishes hiv type-1 and hiv type-2 infections Science  1987 237:1346-1349  DOI:10.1126/science.2888192  PMID:2888192
    • Gnann, J. W., Schwimmbeck, P. L., Nelson, J. A., Truax, A. B., Oldstone, M. B. A. Diagnosis of aids by using a 12-amino acid peptide representing an immunodominant epitope of the human-immunodeficiency-virus Journal of Infectious Diseases  1987 156:261-267  PMID:2439614
    • Gnann, J. W., Nelson, J. A., Oldstone, M. B. A. Fine mapping of an immunodominant domain in the transmembrane glycoprotein of human-immunodeficiency-virus Journal of Virology  1987 61:2639-2641  PMID:2439707  PMCID:PMC255715
    • Schwimmbeck, P. L., Yu, D. T. Y., Oldstone, M. B. A. Autoantibodies to hla b27 in the sera of hla b27 patients with ankylosing-spondylitis and reiters-syndrome - molecular mimicry with klebsiella-pneumoniae as potential mechanism of autoimmune-disease Journal of Experimental Medicine  1987 166:173-181  DOI:10.1084/jem.166.1.173  PMID:2439632
    • Klavinskis, L. S., Oldstone, M. B. A. Lymphocytic choriomeningitis virus can persistently infect thyroid epithelial-cells and perturb thyroid-hormone production Journal of General Virology  1987 68:1867-1873  DOI:10.1099/0022-1317-68-7-1867  PMID:3598562
    • Patterson, S., Byrne, J. A., Lampert, P. W., Oldstone, M. B. A. Morphological analysis of the interactions between lymphocytic choriomeningitis virus-specific cloned cytotoxic t-cells and virus-infected targets Laboratory Investigation  1987 57:29-36  PMID:3496491
    • Buchmeier, M. J., Southern, P. J., Parekh, B. S., Wooddell, M. K., Oldstone, M. B. A. Site-specific antibodies define a cleavage site conserved among arenavirus gp-c glycoproteins Journal of Virology  1987 61:982-985  PMID:3546729  PMCID:PMC254053
    • Southern, P. J., Singh, M. K., Riviere, Y., Jacoby, D. R., Buchmeier, M. J., Oldstone, M. B. A. Molecular characterization of the genomic-s rna segment from lymphocytic choriomeningitis virus Virology  1987 157:145-155  DOI:10.1016/0042-6822(87)90323-0  PMID:3824905
    • Valsamakis, A., Riviere, Y., Oldstone, M. B. A. Perturbation of differentiated functions in vivo during persistent viral infection. III. Decreased growth hormone mRNA Virology  1987 156:214-220  DOI:10.1016/0042-6822(87)90400-4  PMID:3811236
    • Oldstone, M. B. A. Immunotherapy for virus-infection Current Topics in Microbiology and Immunology  1987 134:211-221  PMID:3495409
    • Oldstone, M. B. A. Molecular basis of viral persistence AIDS Research and Human Retroviruses  1987 3:207-211  DOI:10.1089/aid.1987.3.207  PMID:3318885
    • Tishon, A., Oldstone, M. B. A. Persistent virus infection associated with chemical manifestations of diabetes. II. Role of viral strain, environmental insult, and host genetics American Journal of Pathology  1987 126:61-72  PMID:2949622  PMCID:PMC1899557
    • Francis, S. J., Southern, P. J., Valsamakis, A., Oldstone, M. B. A. State of viral genome and proteins during persistent lymphocytic choriomeningitis virus-infection Current Topics in Microbiology and Immunology  1987 133:67-88  PMID:2435462
    • Oldstone, M. B. A. The arenaviruses: an introduction Current Topics in Microbiology and Immunology  1987 134:1-4  DOI:10.1007/978-3-642-71726-0_1  PMID:3581897
    • Ahmed, R., King, C. C., Oldstone, M. B. A. Virus-lymphocyte interaction: T cells of the helper subset are infected with lymphocytic choriomeningitis virus during persistent infection in vivo Journal of Virology  1987 61:1571-1576  PMID:2952807  PMCID:PMC254137
    • McChesney, M. B., Oldstone, M. B. A. Viruses perturb lymphocyte functions - selected principles characterizing virus-induced immunosuppression Annual Review of Immunology  1987 5:279-304  DOI:10.1146/annurev.immunol.5.1.279  PMID:3036182
    • Dyrberg, T., Oldstone, M. B. A. Peptides as antigens - importance of orientation Journal of Experimental Medicine  1986 164:1344-1349  DOI:10.1084/jem.164.4.1344  PMID:3760779
    • Blount, P., Elder, J., Lipkin, W. I., Southern, P. J., Buchmeier, M. J., Oldstone, M. B. A. Dissecting the molecular anatomy of the nervous system: analysis of RNA and protein expression in whole body sections of laboratory animals Brain Research  1986 382:257-265  DOI:10.1016/0006-8993(86)91335-1  PMID:2428441
    • Wiley, C. A., Schrier, R. D., Nelson, J. A., Lampert, P. W., Oldstone, M. B. A. Cellular-localization of human immunodeficiency virus-infection within the brains of acquired-immune-deficiency-syndrome patients Proceedings of the National Academy of Sciences of the United States of America  1986 83:7089-7093  DOI:10.1073/pnas.83.18.7089  PMID:3018755
    • Riviere, Y., Oldstone, M. B. A. Genetic reassortants of lymphocytic choriomeningitis virus - unexpected disease and mechanism of pathogenesis Journal of Virology  1986 59:363-368  PMID:2426464  PMCID:PMC253085
    • Oldstone, M. B. A. Distortion of cell functions by noncytotoxic viruses Hospital Practice  1986 21:82-92  PMID:3088015
    • Schrier, R. D., Oldstone, M. B. A. Recent clinical isolates of cytomegalovirus suppress human cytomegalovirus-specific human-leukocyte antigen-restricted cytotoxic lymphocyte-t activity Journal of Virology  1986 59:127-131  PMID:3012111  PMCID:PMC253047
    • Schrier, R. D., Rice, G. P. A., Oldstone, M. B. A. Suppression of natural-killer cell-activity and t-cell proliferation by fresh isolates of human cytomegalovirus Journal of Infectious Diseases  1986 153:1084-1091  PMID:2422296
    • Oldstone, M. B. A., Blount, P., Southern, P. J., Lampert, P. W. Cytoimmunotherapy for persistent virus-infection reveals a unique clearance pattern from the central-nervous-system Nature  1986 321:239-243  DOI:10.1038/321239a0  PMID:3086743
    • Lipkin, W. I., Oldstone, M. B. A. Analysis of endogenous and exogenous antigens in the nervous-system using whole animal sections Journal of Neuroimmunology  1986 11:251-257  PMID:2420825
    • McChesney, M. B., Fujinami, R. S., Lampert, P. W., Oldstone, M. B. A. Viruses disrupt functions of human-lymphocytes .2. Measles-virus suppresses antibody-production by acting on lymphocytes-b Journal of Experimental Medicine  1986 163:1331-1336  PMID:3486248  PMCID:PMC2188085
    • Wiley, C. A., Schrier, R. D., Denaro, F. J., Nelson, J. A., Lampert, P. W., Oldstone, M. B. A. Localization of cytomegalovirus proteins and genome during fulminant central-nervous-system infection in an aids patient Journal of Neuropathology and Experimental Neurology  1986 45:127-140  DOI:10.1097/00005072-198603000-00003  PMID:3005516
    • Francis, S. J., Singh, M. K., Oldstone, M. B. A., Southern, P. J. Analysis of lymphocytic choriomeningitis virus gene expression in acutely and persistently infected mice Medical Microbiology and Immunology  1986 175:105-108  DOI:10.1007/bf02122426  PMID:3724658
    • Riviere, Y., Southern, P. J., Ahmed, R., Oldstone, M. B. A. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. V. Recognition is restricted to gene products encoded by the viral S RNA segment Journal of Immunology  1986 136:304-307  PMID:3484391
    • Byrne, J. A., Oldstone, M. B. A. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. VI. Migration and activity in vivo in acute and persistent infection Journal of Immunology  1986 136:698-704  PMID:2416821
    • Valsamakis, V., Southern, P., Blount, P., Ahmed, R., Buchmeier, M. J., Oldstone, M. B. A. Dissecting the molecular anatomy of persistent infection with lymphocytic choriomeningitis virus Medical Microbiology and Immunology  1986 175:97-99  DOI:10.1007/bf02122424  PMID:3724670
    • Buchmeier, M. J., Southern, P. J., Parekh, B. S., Oldstone, M. B. A. Molecular and topographic analysis of the glycoproteins of lymphocytic choriomeningitis virus Medical Microbiology and Immunology  1986 175:71-72  DOI:10.1007/bf02122418  PMID:2425233
    • Srinivasappa, J., Saegusa, J., Prabhakar, B. S., Gentry, M. K., Buchmeier, M. J., Wiktor, T. J., Koprowski, H., Oldstone, M. B. A., Notkins, A. L. Molecular mimicry - frequency of reactivity of monoclonal antiviral antibodies with normal-tissues Journal of Virology  1986 57:397-401  PMID:3753614  PMCID:PMC252745
    • Dyrberg, T., Oldstone, M. B. A. Peptides as probes to study molecular mimicry and virus-induced autoimmunity Current Topics in Microbiology and Immunology  1986 130:25-37  PMID:3536327
    • Klavinskis, L. S., Oldstone, M. B. A. Perturbation of endocrine functions during persistent infection of mice with lymphocytic choriomeningitis virus Medical Microbiology and Immunology  1986 175:117-119  DOI:10.1007/bf02122429  PMID:3724660
    • Riviere, Y., Ahmed, R., Oldstone, M. B. A. The use of lymphocytic choriomeningitis virus reassortants to map viral genes causing virulence Medical Microbiology and Immunology  1986 175:191-192  DOI:10.1007/bf02122448  PMID:3724665
    • Fujinami, R. S., Oldstone, M. B. A. Amino-acid homology between the encephalitogenic site of myelin basic-protein and virus - mechanism for autoimmunity Science  1985 230:1043-1045  DOI:10.1126/science.2414848  PMID:2414848
    • Anderson, J., Byrne, J. A., Schreiber, R., Patterson, S., Oldstone, M. B. A. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus and in vitro properties Journal of Virology  1985 53:552-560  PMID:3918175  PMCID:PMC254670
    • Sissons, J. G. P., Colby, S. D., Harrison, W. O., Oldstone, M. B. A. Cytotoxic lymphocytes generated in vivo with acute measles virus infection Clinical Immunology and Immunopathology  1985 34:60-68  DOI:10.1016/0090-1229(85)90007-8  PMID:3871183
    • Schrier, R. D., Nelson, J. A., Oldstone, M. B. A. Detection of human cytomegalo-virus in peripheral-blood lymphocytes in a natural infection Science  1985 230:1048-1051  DOI:10.1126/science.2997930  PMID:2997930
    • Riviere, Y., Ahmed, R., Southern, P. J., Buchmeier, M. J., Oldstone, M. B. A. Genetic-mapping of lymphocytic choriomeningitis virus pathogenicity - virulence in guinea-pigs is associated with the l rna segment Journal of Virology  1985 55:704-709  PMID:4020963  PMCID:PMC255050
    • Rice, G. P. A., Woelfel, E. L., Talbot, P. J., Braheny, S. L., Sipe, J. C., Knobler, R. L., Merigan, T. C., Oldstone, M. B. A. Immunological complications in multiple-sclerosis patients receiving interferon Annals of Neurology  1985 18:439-442  DOI:10.1002/ana.410180405  PMID:2416266
    • Oldstone, M. B. A., Ahmed, R., Buchmeier, M. J., Blount, P., Tishon, A. Perturbation of differentiated functions during viral infection in vivo. I. Relationship of lymphocytic choriomeningitis virus and host strains to growth hormone deficiency Virology  1985 142:158-174  DOI:10.1016/0042-6822(85)90430-1  PMID:2414901
    • Riviere, Y., Ahmed, R., Southern, P., Oldstone, M. B. A. Perturbation of differentiated functions during viral infection in vivo. II. Viral reassortants map growth hormone defect to the S RNA of the lymphocytic choriomeningitis virus genome Virology  1985 142:175-182  DOI:10.1016/0042-6822(85)90431-3  PMID:4060570
    • Riviere, Y., Ahmed, R., Southern, P. J., Buchmeier, M. J., Dutko, F. J., Oldstone, M. B. A. The s rna segment of lymphocytic choriomeningitis virus codes for the nucleoprotein and glycoprotein-1 and glycoprotein-2 Journal of Virology  1985 53:966-968  PMID:3973970  PMCID:PMC254733
    • Oldstone, M. B. A., Ahmed, R., Byrne, J., Buchmeier, M. J., Riviere, Y., Southern, P. Virus and immune-responses - lymphocytic choriomeningitis virus as a prototype model of viral pathogenesis British Medical Bulletin  1985 41:70-74  PMID:3882190
    • Rodriguez, M., Garrett, R. S., Raitt, M., Lampert, P. W., Oldstone, M. B. A. Virus persists in beta-cells of islets of langerhans and infection is associated with chemical manifestations of diabetes .2. Morphologic observations American Journal of Pathology  1985 121:497-504  PMID:3907367  PMCID:PMC1887922
    • Sipe, J. C., Knobler, R. L., Braheny, S. L., Rice, G. P. A., Panitch, H. S., Oldstone, M. B. A. A neurologic rating-scale (nrs) for use in multiple-sclerosis Neurology  1984 34:1368-1372  PMID:6541311
    • Southern, P. J., Blount, P., Oldstone, M. B. A. Analysis of persistent virus-infections by insitu hybridization to whole-mouse sections Nature  1984 312:555-558  DOI:10.1038/312555a0  PMID:6504163
    • Fujinami, R. S., Norrby, E., Oldstone, M. B. A. Antigenic modulation induced by monoclonal-antibodies - antibodies to measles-virus hemagglutinin alters expression of other viral polypeptides in infected-cells Journal of Immunology  1984 132:2618-2621  PMID:6546943
    • Byrne, J. A., Ahmed, R., Oldstone, M. B. A. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus. I. Generation and recognition of virus strains and H-2b mutants Journal of Immunology  1984 133:433-439  PMID:6202788
    • Byrne, J. A., Oldstone, M. B. A. Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo Journal of Virology  1984 51:682-686  PMID:6332201  PMCID:PMC255828
    • Knobler, R. L., Panitch, H. S., Braheny, S. L., Sipe, J. C., Rice, G. P. A., Huddlestone, J. R., Francis, G. S., Hooper, C. J., Kaminlewis, R. M., Johnson, K. P., Oldstone, M. B. A., Merigan, T. C. Clinical-trial of natural alpha interferon in multiple-sclerosis Annals of the New York Academy of Sciences  1984 436:382-388  DOI:10.1111/j.1749-6632.1984.tb14809.x  PMID:6398020
    • Rice, G. P. A., Schrier, R. D., Oldstone, M. B. A. Cytomegalovirus infects human-lymphocytes and monocytes - virus expression is restricted to immediate-early gene-products Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  1984 81:6134-6138  DOI:10.1073/pnas.81.19.6134  PMID:6091137
    • Rice, G. P. A., Finney, D., Braheny, S. L., Knobler, R. L., Sipe, J. C., Oldstone, M. B. A. Disease-activity markers in multiple-sclerosis - another look at suppressor cells defined by monoclonal antibody-okt4, antibody-okt5, and antibody okt8 Journal of Neuroimmunology  1984 6:75-84  DOI:10.1016/0165-5728(84)90028-6  PMID:6233298
    • Knobler, R. L., Tunison, L. A., Oldstone, M. B. A. Host genetic-control of mouse hepatitis-virus type-4 (jhm strain) replication .1. Restriction of virus amplification and spread in macrophages from resistant mice Journal of General Virology  1984 65:1543-1548  DOI:10.1099/0022-1317-65-9-1543  PMID:6088681
    • Jacoby, D. R., Olding, L. B., Oldstone, M. B. A. Immunological regulation of fetal maternal balance Advances in Immunology  1984 35:157-208  DOI:10.1016/s0065-2776(08)60576-3  PMID:6235725
    • Ahmed, R., Salmi, A., Butler, L. D., Chiller, J. M., Oldstone, M. B. A. Selection of genetic-variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice - role in suppression of cyto-toxic lymphocyte-t response and viral persistence Journal of Experimental Medicine  1984 160:521-540  DOI:10.1084/jem.160.2.521  PMID:6332167
    • Knobler, R. L., Panitch, H. S., Braheny, S. L., Sipe, J. C., Rice, G. P. A., Huddlestone, J. R., Francis, G. S., Hooper, C. J., Kaminlewis, R. M., Johnson, K. P., Oldstone, M. B. A., Merigan, T. C. Systemic alpha-interferon therapy of multiple-sclerosis Neurology  1984 34:1273-1279  PMID:6384817
    • Rice, G. P. A., Sipe, J. C., Braheny, S. L., Knobler, R. L., Finney, D. A., Oldstone, M. B. A. The failure of monoclonal antibody-defined lymphocyte subsets to monitor disease-activity in patients with multiple-sclerosis Annals of the New York Academy of Sciences  1984 436:271-280  DOI:10.1111/j.1749-6632.1984.tb14799.x  PMID:6241819
    • Oldstone, M. B. A., Rodriguez, M., Daughaday, W. H., Lampert, P. W. Viral perturbation of endocrine function - disordered cell-function leads to disturbed homeostasis and disease Nature  1984 307:278-281  DOI:10.1038/307278a0  PMID:6694729
    • Ahmed, R., Byrne, J. A., Oldstone, M. B. A. Virus specificity of cytotoxic T lymphocytes generated during acute lymphocytic choriomeningitis virus infection: role of the H-2 region in determining cross-reactivity for different lymphocytic choriomeningitis virus strains Journal of Virology  1984 51:34-41  PMID:6610062  PMCID:PMC254395
    • Casali, P., Rice, G. P. A., Oldstone, M. B. A. Viruses disrupt functions of human-lymphocytes - effects of measles-virus and influenza-virus on lymphocyte-mediated killing and antibody-production Journal of Experimental Medicine  1984 159:1322-1337  DOI:10.1084/jem.159.5.1322  PMID:6716049
    • Rice, G. P. A., Casali, P., Oldstone, M. B. A. A new solid-phase enzyme-linked immunosorbent-assay for specific antibodies to measles-virus Journal of Infectious Diseases  1983 147:1055-1059  PMID:6343523
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    • Casali, P., Oldstone, M. B. A. Immune-complexes in viral-infection Current Topics in Microbiology and Immunology  1983 104:7-48  PMID:6307599
    • Dales, S., Fujinami, R. S., Oldstone, M. B. A. Infection with vaccinia favors the selection of hybridomas synthesizing autoantibodies against intermediate filaments, one of them cross-reacting with the virus hemagglutinin Journal of Immunology  1983 131:1546-1553  PMID:6684139
    • Oldstone, M. B. A., Fujinami, R. S., Tishon, A., Finney, D., Powell, H. C., Lampert, P. W. Mapping of the major histocompatibility complex and viral-antigens on the plasma-membrane of a measles virus-infected cell Virology  1983 127:426-437  DOI:10.1016/0042-6822(83)90155-1  PMID:6575495
    • Fujinami, R. S., Oldstone, M. B. A., Wroblewska, Z., Frankel, M. E., Koprowski, H. Molecular mimicry in virus-infection - crossreaction of measles-virus phosphoprotein or of herpes-simplex virus protein with human intermediate filaments Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  1983 80:2346-2350  DOI:10.1073/pnas.80.8.2346  PMID:6300911
    • Rice, G. P. A., Casali, P., Merigan, T. C., Oldstone, M. B. A. Natural-killer cell-activity in patients with multiple-sclerosis given alpha-interferon Annals of Neurology  1983 14:333-338  DOI:10.1002/ana.410140312  PMID:6638954
    • Oldstone, M. B. A., Jensen, F., Elder, J., Dixon, F. J., Lampert, P. W. Pathogenesis of the slow disease of the central nervous-system associated with wild mouse virus .3. Role of input virus and mcf recombinants in disease Virology  1983 128:154-165  DOI:10.1016/0042-6822(83)90326-4  PMID:6308890
    • Rodriguez, M., Vonwedel, R. J., Garrett, R. S., Lampert, P. W., Oldstone, M. B. A. Pituitary dwarfism in mice persistently infected with lymphocytic choriomeningitis virus Laboratory Investigation  1983 49:48-53  PMID:6865330
    • Dales, S., Fujinami, R. S., Oldstone, M. B. A. Serologic relatedness between thy-1.2 and actin revealed by monoclonal-antibody Journal of Immunology  1983 131:1332-1338  PMID:6136544
    • Rosenthal, K. L., Oldstone, M. B. A., Hengartner, H., Zinkernagel, R. M. Specificity of in vitro cyto-toxic t-cell clones directed against vesicular stomatitis-virus Journal of Immunology  1983 131:475-478  PMID:6190924
    • Rodriguez, M., Buchmeier, M. J., Oldstone, M. B. A., Lampert, P. W. Ultrastructural-localization of viral-antigens in the cns of mice persistently infected with lymphocytic choriomeningitis virus (lcmv) American Journal of Pathology  1983 110:95-100  PMID:6336906  PMCID:PMC1916133
    • Oldstone, M. B. A., Tishon, A., Buchmeier, M. J. Virus-induced immune complex disease: genetic control of C1q binding complexes in the circulation of mice persistently infected with lymphocytic choriomeningitis virus Journal of Immunology  1983 130:912-918  PMID:6217255
    • Cooper, N. R., Oldstone, M. B. A. Virus-infected cells, igg, and the alternative complement pathway Immunology Today  1983 4:107-108  DOI:10.1016/0167-5699(83)90018-x  PMID:25291475
    • Knobler, R. L., Haspel, M. V., Duboisdalcq, M., Lampert, P. W., Oldstone, M. B. A. Host and virus factors associated with CNS cellular tropism leading to encephalomyelitis or demyelination induced by the JHM strain of mouse hepatitis virus Advances in Experimental Medicine and Biology  1982 142:341-348  DOI:10.1007/978-1-4757-0456-3_28  PMID:6278890
    • Oldstone, M. B. A. Immunopathology of persistent viral infections Hospital Practice  1982 17:61-72
    • Abb, J., Deinhardt, F., Zander, H., Tenser, R. B., Rapp, F., Goust, J. M., Fudenberg, H. H., Vilcek, J., Ho, M., Merigan, T. C., Oldstone, M. B. A., Jackson, G. G. Infectious Diseases Society of America. Trials of interferon therapy for multiple sclerosis Journal of Infectious Diseases  1982 146:109-115  PMID:6177805
    • Dales, S., Oldstone, M. B. A. Localization at high-resolution of antibody-induced mobilization of vaccinia virus hemagglutinin and the major histocompatibility antigens on the plasma-membrane of infected-cells Journal of Experimental Medicine  1982 156:1435-1447  DOI:10.1084/jem.156.5.1435  PMID:7130903
    • Casali, P., Oldstone, M. B. A. Mechanisms of killing of measles virus-infected cells by human-lymphocytes - interferon associated and unassociated cell-mediated cyto-toxicity Cellular Immunology  1982 70:330-344  DOI:10.1016/0008-8749(82)90334-3  PMID:6181900
    • Oldstone, M. B. A., Buchmeier, M. J. Restricted expression of viral glycoprotein in cells of persistently infected mice Nature  1982 300:360-362  DOI:10.1038/300360a0  PMID:7144891
    • Knobler, R. L., Tunison, L. A., Lampert, P. W., Oldstone, M. B. A. Selected mutants of mouse hepatitis-virus type-4 (jhm-strain) induce different cns diseases - pathobiology of disease induced by wild-type and mutant-ts8 and mutant-ts15 in balb/c and sjl/j mice American Journal of Pathology  1982 109:157-168  PMID:6291396  PMCID:PMC1916093
    • Huddlestone, J. R., Oldstone, M. B. A. Suppressor T cells are activated in vivo in patients with multiple sclerosis coinciding with remission from acute attack Journal of Immunology  1982 129:915-917  PMID:6213712
    • Sissons, J. G. P., Schreiber, R. D., Cooper, N. R., Oldstone, M. B. A. The role of antibody and complement in lysing virus-infected cells Medical Microbiology and Immunology  1982 170:221-227  DOI:10.1007/bf02123312  PMID:7048046
    • Knobler, R. L., Lampert, P. W., Oldstone, M. B. A. Virus persistence and recurring demyelination produced by a temperature-sensitive mutant of mhv-4 Nature  1982 298:279-280  DOI:10.1038/298279a0  PMID:6283382
    • Oldstone, M. B. A., Sinha, Y. N., Blount, P., Tishon, A., Rodriguez, M., Vonwedel, R., Lampert, P. W. Virus-induced alterations in homeostasis: alteration in differentiated functions of infected cells in vivo Science  1982 218:1125-1127  DOI:10.1126/science.7146898  PMID:7146898
    • Dutko, F. J., Oldstone, M. B. A. Cytomegalovirus causes a latent infection in undifferentiated cells and is activated by induction of cell-differentiation Journal of Experimental Medicine  1981 154:1636-1651  DOI:10.1084/jem.154.5.1636  PMID:6271894
    • Fujinami, R. S., Oldstone, M. B. A. Failure to cleave measles-virus fusion protein in lymphoid-cells - a possible mechanism for viral persistence in lymphocytes Journal of Experimental Medicine  1981 154:1489-1499  DOI:10.1084/jem.154.5.1489  PMID:6895382
    • Hoffman, P. M., Robbins, D. S., Oldstone, M. B. A., Gibbs, C. J., Gajdusek, D. C. Humoral immunity in guamanians with amyotrophic lateral sclerosis and parkinsonism-dementia Annals of Neurology  1981 10:193-196  DOI:10.1002/ana.410100210  PMID:7283404
    • Fujinami, R. S., Sissons, J. G. P., Oldstone, M. B. A. Immune reactive measles virus polypeptides on the cell's surface: turnover and relationship of the glycoproteins to each other and to HLA determinants Journal of Immunology  1981 127:935-940  PMID:6167634
    • Casali, P., Sissons, J. G. P., Buchmeier, M. J., Oldstone, M. B. A. In vitro generation of human cytotoxic lymphocytes by virus. Viral glycoproteins induce nonspecific cell-mediated cytotoxicity without release of interferon Journal of Experimental Medicine  1981 154:840-855  DOI:10.1084/jem.154.3.840  PMID:7276828  PMCID:PMC2186447
    • Harfast, B., Huddlestone, J. R., Casali, P., Merigan, T. C., Oldstone, M. B. A. Interferon acts directly on human lymphocytes-b to modulate immunoglobulin-synthesis Journal of Immunology  1981 127:2146-2150  PMID:6170691
    • Buchmeier, M. J., Lewicki, H. A., Tomori, O., Oldstone, M. B. A. Monoclonal-antibodies to lymphocytic choriomeningitis and pichinde viruses - generation, characterization, and cross-reactivity with other arenaviruses Virology  1981 113:73-85  DOI:10.1016/0042-6822(81)90137-9  PMID:6267791
    • Knobler, R. L., Haspel, M. V., Oldstone, M. B. A. Mouse hepatitis-virus type-4 (jhm strain)-induced fatal central nervous-system disease .1. Genetic-control and the murine neuron as the susceptible site of disease Journal of Experimental Medicine  1981 153:832-843  DOI:10.1084/jem.153.4.832  PMID:6265583
    • Harfast, B., Huddlestone, J. R., Braheny, S., Seybold, M. E., Oldstone, M. B. A. Myasthenia-gravis - in vitro immunoglobulin production with pokeweed mitogen challenge and lymphocyte-b and lymphocyte-t competence Clinical Immunology and Immunopathology  1981 20:336-345  DOI:10.1016/0090-1229(81)90144-6  PMID:6210478
    • Casali, P., Sissons, J. G. P., Fujinami, R. S., Oldstone, M. B. A. Purification of measles-virus glycoproteins and their integration into artificial lipid-membranes Journal of General Virology  1981 54:161-171  DOI:10.1099/0022-1317-54-1-161  PMID:7288404
    • Knobler, R. L., Duboisdalcq, M., Haspel, M. V., Claysmith, A. P., Lampert, P. W., Oldstone, M. B. A. Selective localization of wild-type and mutant mouse hepatitis-virus (jhm strain) antigens in cns tissue by fluorescence, light and electron-microscopy Journal of Neuroimmunology  1981 1:81-92  DOI:10.1016/0165-5728(81)90010-2  PMID:6276437
    • Fujinami, R. S., Oldstone, M. B. A. Alterations in expression of measles-virus polypeptides by antibody - molecular events in antibody-induced antigenic modulation Journal of Immunology  1980 125:78-85  PMID:7381212
    • Sissons, J. G. P., Oldstone, M. B. A., Schreiber, R. D. Antibody-independent activation of the alternative complement pathway by measles virus-infected cells Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  1980 77:559-562  DOI:10.1073/pnas.77.1.559  PMID:6928644
    • Oldstone, M. B. A., Tishon, A., Dutko, F. J., Kennedy, S. I. T., Holland, J. J., Lampert, P. W. Does the major histocompatibility complex serve as a specific receptor for semliki forest virus Journal of Virology  1980 34:256-265  PMID:7373708  PMCID:PMC288691
    • Sissons, J. G. P., Oldstone, M. B. A. Killing of virus-infected cells by cyto-toxic lymphocytes Journal of Infectious Diseases  1980 142:114-119  PMID:6249872
    • Oldstone, M. B. A., Jensen, F., Dixon, F. J., Lampert, P. W. Pathogenesis of the slow disease of the central nervous-system associated with wild mouse virus .2. Role of virus and host gene-products Virology  1980 107:180-193  DOI:10.1016/0042-6822(80)90283-4  PMID:6255677
    • Brautigam, A. R., Oldstone, M. B. A. Replication of murine cytomegalovirus in reproductive tissues American Journal of Pathology  1980 98:213-223  PMID:6243206  PMCID:PMC1903396
    • Doyle, L. B., Doyle, M. V., Oldstone, M. B. A. Susceptibility of newborn mice with h-2k backgrounds to lymphocytic choriomeningitis virus-infection Immunology  1980 40:589-596  PMID:6776035  PMCID:PMC1458105
    • Oldstone, M. B. A., Buchmeier, M. J., Doyle, M. V., Tishon, A. Virus-induced immune complex disease: specific anti-viral antibody and C1q binding material in the circulation during persistent lymphocytic choriomeningitis virus infection Journal of Immunology  1980 124:831-838  PMID:6444319
    • Huddlestone, J. R., Lampert, P. W., Oldstone, M. B. A. Virus-lymphocyte interactions - infection of tg and tm subsets by measles-virus Clinical Immunology and Immunopathology  1980 15:502-509  DOI:10.1016/0090-1229(80)90062-8  PMID:6966202
    • Sissons, J. G. P., Cooper, N. R., Oldstone, M. B. A. Alternative complement pathway-mediated lysis of measles-virus infected-cells - induction by igg antibody bound to individual viral glycoproteins and comparative efficacy of f(ab')2 and fab' fragments Journal of Immunology  1979 123:2144-2149  PMID:489977
    • Oldstone, M. B. A., Lampert, P. W. Antibody mediated complement dependent lysis of virus-infected cells Springer Seminars in Immunopathology  1979 2:261-283
    • Fujinami, R. S., Oldstone, M. B. A. Antiviral antibody reacting on the plasma membrane alters measles virus expression inside the cell Nature  1979 279:529-530  DOI:10.1038/279529a0  PMID:450095
    • Huddlestone, J. R., Merigan, T. C., Oldstone, M. B. A. Induction and kinetics of natural killer cells in humans following interferon therapy Nature  1979 282:417-419  DOI:10.1038/282417a0  PMID:503223
    • Huddlestone, J. R., Oldstone, M. B. A. Lymphocyte-mediated cytotoxicity to measles-virus in patients with multiple-sclerosis Clinical Immunology and Immunopathology  1979 13:444-451  DOI:10.1016/0090-1229(79)90087-4  PMID:487666
    • Sissons, J. G. P., Schreiber, R. D., Perrin, L. H., Cooper, N. R., Mullereberhard, H. J., Oldstone, M. B. A. Lysis of measles virus-infected cells by the purified cytolytic alternative complement pathway and antibody Journal of Experimental Medicine  1979 150:445-454  PMID:479760  PMCID:PMC2185658
    • Dutko, F. J., Oldstone, M. B. A. Murine cytomegalo-virus infects spermatogenic cells Proceedings of the National Academy of Sciences of the United States of America  1979 76:2988-2991  DOI:10.1073/pnas.76.6.2988  PMID:223164
    • Brautigam, A. R., Dutko, F. J., Olding, L. B., Oldstone, M. B. A. Pathogenesis of murine cytomegalo-virus infection - macrophage as a permissive cell for cytomegalo-virus infection, replication and latency Journal of General Virology  1979 44:349-359  DOI:10.1099/0022-1317-44-2-349  PMID:230287
    • Buchmeier, M. J., Oldstone, M. B. A. Protein-structure of lymphocytic choriomeningitis virus - evidence for a cell-associated precursor of the virion glycopeptides Virology  1979 99:111-120  DOI:10.1016/0042-6822(79)90042-4  PMID:494491
    • Huddlestone, J. R., Oldstone, M. B. A. T-suppressor lymphocytes-(tg) fluctuate in parallel with changes in the clinical course of patients with multiple-sclerosis Journal of Immunology  1979 123:1615-1618  PMID:314466
    • Perrin, L. H., Reynolds, D., Zinkernagel, R., Oldstone, M. B. A. Generation of virus-specific cytolytic activity in human peripheral lymphocytes after vaccination with vaccinia virus and measles-virus Medical Microbiology and Immunology  1978 166:71-79  DOI:10.1007/bf02121136  PMID:723792
    • Oldstone, M. B. A., Tishon, A. Immunological injury in measles-virus infection .4. Antigenic modulation and abrogation of lymphocyte lysis of virus-infected cells Clinical Immunology and Immunopathology  1978 9:55-62  DOI:10.1016/0090-1229(78)90120-4  PMID:618410
    • Doyle, M. V., Oldstone, M. B. A. Interactions between viruses and lymphocytes. I. In vivo replication of lymphocytic choriomeningitis virus in mononuclear cells during both chronic and acute viral infections Journal of Immunology  1978 121:1262-1269  PMID:308960
    • Buchmeier, M. J., Elder, J. H., Oldstone, M. B. A. Protein-structure of lymphocytic choriomeningitis virus - identification of virus structural and cell associated polypeptides Virology  1978 89:133-145  DOI:10.1016/0042-6822(78)90047-8  PMID:685174
    • Haspel, M. V., Lampert, P. W., Oldstone, M. B. A. Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyelination Proceedings of the National Academy of Sciences of the United States of America  1978 75:4033-4036  DOI:10.1073/pnas.75.8.4033  PMID:279022
    • Buchmeier, M. J., Oldstone, M. B. A. Virus-induced immune complex disease: identification of specific viral antigens and antibodies deposited in complexes during chronic lymphocytic choriomeningitis virus infection Journal of Immunology  1978 120:1297-1304  PMID:76662
    • Oldstone, M. B. A., Tishon, A., Moretta, L. Active thymus derived suppressor lymphocytes in human cord blood Nature  1977 269:333-335  DOI:10.1038/269333a0  PMID:302917
    • Oldstone, M. B. A., Holmstoen, J., Welsh, R. M. Alterations of acetylcholine enzymes in neuroblastoma-cells persistently infected with lymphocytic choriomeningitis virus Journal of Cellular Physiology  1977 91:459-472  DOI:10.1002/jcp.1040910316  PMID:193868
    • Perrin, L. H., Oldstone, M. B. A. Formation and fate of virus antigen-antibody complexes Journal of Immunology  1977 118:316-322  PMID:830754
    • Haspel, M. V., Pellegrino, M. A., Lampert, P. W., Oldstone, M. B. A. Human histocompatibility determinants and virus-antigens - effect of measles-virus infection on hla expression Journal of Experimental Medicine  1977 146:146-156  DOI:10.1084/jem.146.1.146  PMID:68989
    • Perrin, L. H., Zinkernagel, R. M., Oldstone, M. B. A. Immune-response in humans after vaccination with vaccinia virus - generation of a virus-specific cytotoxic activity by human peripheral lymphocytes Journal of Experimental Medicine  1977 146:949-969  DOI:10.1084/jem.146.4.949  PMID:302316
    • Perrin, L. H., Tishon, A., Oldstone, M. B. A. Immunological injury in measles-virus infection .3. Presence and characterization of human cytotoxic lymphocytes Journal of Immunology  1977 118:282-290  PMID:830751
    • Hoffsten, P. E., Oldstone, M. B. A., Dixon, F. J. Immunopathology of adoptive immunization in mice chronically infected with lymphocytic choriomeningitis virus Clinical Immunology and Immunopathology  1977 7:44-52  DOI:10.1016/0090-1229(77)90028-9  PMID:852153
    • Welsh, R. M., Oldstone, M. B. A. Inhibition of immunological injury of cultured-cells infected with lymphocytic choriomeningitis virus - role of defective interfering virus in regulating viral antigenic expression Journal of Experimental Medicine  1977 145:1449-1468  DOI:10.1084/jem.145.6.1449  PMID:301173
    • Merigan, T. C., Oldstone, M. B. A., Welsh, R. M. Interferon-production during lymphocytic choriomeningitis virus-infection of nude and normal mice Nature  1977 268:67-68  DOI:10.1038/268067a0  PMID:301989
    • Oldstone, M. B. A., Lampert, P. W., Lee, S., Dixon, F. J. Pathogenesis of slow disease of central nervous-system associated with wm-1504-e virus American Journal of Pathology  1977 88:193-212  PMID:195470  PMCID:PMC2032160
    • Welsh, R. M., Lampert, P. W., Oldstone, M. B. A. Prevention of virus-induced cerebellar disease by defective-interfering lymphocytic choriomeningitis virus Journal of Infectious Diseases  1977 136:391-399  PMID:903677
    • Welsh, R. M., Lampert, P. W., Burner, P. A., Oldstone, M. B. A. Antibody-complement interactions with purified lymphocytic choriomeningitis virus Virology  1976 73:59-71  DOI:10.1016/0042-6822(76)90060-x  PMID:986722
    • Oldstone, M. B. A., Delvillano, B. C., Dixon, F. J. Autologous immune-responses to major oncornavirus polypeptides in unmanipulated akr-j mice Journal of Virology  1976 18:176-181  PMID:176459  PMCID:PMC515536
    • Zinkernagel, R. M., Oldstone, M. B. A. Cells that express viral-antigens but lack h-2 determinants are not lysed by immune thymus-derived lymphocytes but are lysed by other antiviral immune attack mechanisms Proceedings of the National Academy of Sciences of the United States of America  1976 73:3666-3670  DOI:10.1073/pnas.73.10.3666  PMID:1086476
    • Oldstone, M. B. A., Perrin, L. H., Wilson, C. B., Norris, F. H. Evidence for immune-complex formation in patients with amyotrophic lateral sclerosis Lancet  1976 2:169-172  PMID:73795
    • Oldstone, M. B. A., Haspel, M. V., Pellegrino, M. A., Kingsbury, D. T., Olding, L. Histocompatibility complex and virus infection latency and activation Transplantation Reviews  1976 31:225-239  PMID:785728
    • Welsh, R. M., Jensen, F. C., Cooper, N. R., Oldstone, M. B. A. Inactivation and lysis of oncornaviruses by human-serum Virology  1976 74:432-440  DOI:10.1016/0042-6822(76)90349-4  PMID:62448
    • Holland, J. J., Villarreal, L. P., Welsh, R. M., Oldstone, M. B. A., Kohne, D., Lazzarini, R., Scolnick, E. Long-term persistent vesicular stomatitis-virus and rabies virus-infection of cells in vitro Journal of General Virology  1976 33:193-211  DOI:10.1099/0022-1317-33-2-193  PMID:186559
    • Cooper, N. R., Jensen, F. C., Welsh, R. M., Oldstone, M. B. A. Lysis of rna tumor-viruses by human-serum - direct antibody-independent triggering of classical complement pathway Journal of Experimental Medicine  1976 144:970-984  DOI:10.1084/jem.144.4.970  PMID:62019
    • Joseph, B. S., Perrin, L. H., Oldstone, M. B. A. Measurement of virus antigens on surfaces of hela-cells persistently infected with wild-type and vaccine strains of measles-virus by radioimmune assay Journal of General Virology  1976 30:329-337  DOI:10.1099/0022-1317-30-3-329  PMID:1255135
    • Perrin, L. H., Joseph, B. S., Cooper, N. R., Oldstone, M. B. A. Mechanism of injury of virus-infected cells by antiviral antibody and complement - participation of igg, f(ab')2, and alternative complement pathway Journal of Experimental Medicine  1976 143:1027-1041  DOI:10.1084/jem.143.5.1027  PMID:177712
    • Olding, L. B., Kingsbury, D. T., Oldstone, M. B. A. Pathogenesis of cytomegalovirus infection. Distribution of viral products, immune complexes and autoimmunity during latent murine infection Journal of General Virology  1976 33:267-280  DOI:10.1099/0022-1317-33-2-267  PMID:186563
    • Jondai, M., Klein, G., Oldstone, M. B. A., Bokish, V., Yefenof, E. Surface markers on human b and t lymphocytes .8. Association between complement and epstein-barr virus receptors on human lymphoid-cells Scandinavian Journal of Immunology  1976 5:401-410  DOI:10.1111/j.1365-3083.1976.tb00294.x  PMID:59946
    • Yefenof, E., Klein, G., Jondal, M., Oldstone, M. B. A. Surface markers on human b-lymphocytes and t-lymphocytes .9. 2-color immunofluorescence studies on association between ebv receptors and complement receptors on surface of lymphoid-cell lines International Journal of Cancer  1976 17:693-700  DOI:10.1002/ijc.2910170602  PMID:181330
    • Olding, L. B., Oldstone, M. B. A. Thymus-derived peripheral lymphocytes from human newborns inhibit division of their mothers' lymphocytes Journal of Immunology  1976 116:682-686  PMID:1082891
    • Lampert, P. W., Joseph, B. S., Oldstone, M. B. A. Antibody-induced capping of measles-virus antigens on plasma-membrane studied by electron-microscopy Journal of Virology  1975 15:1248-1255  PMID:49437  PMCID:PMC354580
    • Welsh, R. M., Burner, P. A., Holland, J. J., Oldstone, M. B. A., Thompson, H. A., Villarreal, L. P. Comparison of biochemical and biological properties of standard and defective lymphocytic choriomeningitis virus Bulletin of the World Health Organization  1975 52:403-408  PMID:60182  PMCID:PMC2366663
    • Welsh, R. M., Cooper, N. R., Jensen, F. C., Oldstone, M. B. A. Human-serum lyses rna tumor-viruses Nature  1975 257:612-614  DOI:10.1038/257612a0  PMID:170540
    • Oldstone, M. B. A. Immune-complexes in cancer - demonstration of complexes in mice bearing neuroblastomas Journal of the National Cancer Institute  1975 54:223-228  PMID:1089793
    • Joseph, B. S., Oldstone, M. B. A. Immunological injury in measles-virus infection .2. Suppression of immune injury through antigenic modulation Journal of Experimental Medicine  1975 142:864-876  DOI:10.1084/jem.142.4.864  PMID:1176889
    • Joseph, B. S., Cooper, N. R., Oldstone, M. B. A. Immunological injury of cultured-cells infected with measles-virus Journal of Experimental Medicine  1975 141:761-774  PMID:1092789  PMCID:PMC2189741
    • Olding, L. B., Jensen, F. C., Oldstone, M. B. A. Pathogenesis of cytomegalovirus-infection .1. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction Journal of Experimental Medicine  1975 141:561-572  DOI:10.1084/jem.141.3.561  PMID:163887
    • Oldstone, M. B. A., Welsh, R. M., Joseph, B. S. Pathogenic mechanisms of tissue injury in persistent viral-infections Annals of the New York Academy of Sciences  1975 256:65-72  DOI:10.1111/j.1749-6632.1975.tb36035.x  PMID:169724
    • Oldstone, M. B. A. Relationship between major histocompatibility antigens and disease - possible associations with human arenavirus diseases Bulletin of the World Health Organization  1975 52:479-486  PMID:60183  PMCID:PMC2366647
    • Joseph, B. S., Lampert, P. W., Oldstone, M. B. A. Replication and persistence of measles-virus in defined subpopulations of human leukocytes Journal of Virology  1975 16:1638-1649  PMID:1081602  PMCID:PMC355773
    • Oldstone, M. B. A., Bokisch, V. A., Dixon, F. J., Barbosa, L. H., Fuccillo, D., Sever, J. L. Subacute sclerosing panencephalitis - destruction of human brain-cells by antibody and complement in an autologous system Clinical Immunology and Immunopathology  1975 4:52-58  DOI:10.1016/0090-1229(75)90039-2  PMID:1092498
    • Norris, F. H., Aguilar, M. J., Colton, R. P., Oldstone, M. B. A., Cremer, N. E. Tubular particles in a case of recurrent lymphocytic meningitis followed by amyotrophic lateral sclerosis Journal of Neuropathology and Experimental Neurology  1975 34:133-147  DOI:10.1097/00005072-197503000-00002  PMID:1123648
    • Oldstone, M. B. A. Virus neutralization and virus-induced immune-complex disease - virus-antibody union resulting in immunoprotection or immunological injury - 2 sides of same coin Progress in Medical Virology  1975 19:84-119  PMID:164055
    • Oldstone, M. B., Dixon, F. J. Aging and chronic virus-infection - is there a relationship Federation Proceedings  1974 33:2057-2059  PMID:4420504
    • Joseph, B. S., Oldstone, M. B. Antibody-induced redistribution of measles-virus antigens on cell-surface Journal of Immunology  1974 113:1205-1209  PMID:4606230
    • Oldstone, M. B., Tishon, A., Chiller, J. M. Chronic virus-infection and immune responsiveness .2. Lactic-dehydrogenase virus-infection and immune-response to non-viral antigens Journal of Immunology  1974 112:370-375  PMID:4590825
    • Hollis, V. W., Aoki, T., Barrera, O., Oldstone, M. B., Dixon, F. J. Detection of naturally occurring antibodies to rna-dependent DNA-polymerase of murine leukemia-virus in kidney eluates of akr mice Journal of Virology  1974 13:448-454  PMID:4129792  PMCID:PMC355315
    • Joseph, B. S., Oldstone, M. B. Expression of selected antigens on surface of cultured neural cells Brain Research  1974 80:421-434  DOI:10.1016/0006-8993(74)91027-0  PMID:4138443
    • Cooper, N. R., Polley, M. J., Oldstone, M. B. Failure of terminal complement components to induce lysis of moloney virus transformed lymphocytes Journal of Immunology  1974 112:866-868  PMID:4855965
    • Oldstone, M. B., Cooper, N. R., Larson, D. L. Formation and biologic role of polyoma virus-antibody complexes - critical role for complement Journal of Experimental Medicine  1974 140:549-565  DOI:10.1084/jem.140.2.549  PMID:4367757
    • McDevitt, H. O., Oldstone, M. B., Pincus, T. Histocompatibility-linked genetic-control of specific immune-responses to viral-infection Transplantation Reviews  1974 19:209-225  PMID:4135405
    • Oldstone, M. B. A., Theofilopoulos, A. N., Gunven, P., Klein, G. Immune-complexes associated with neoplasia - presence of epstein-barr virus antigen-antibody complexes in burkitts-lymphoma Intervirology  1974 4:292-302  PMID:4377147
    • Olding, L. B., Benirschke, K., Oldstone, M. B. Inhibition of mitosis of lymphocytes from human adults by lymphocytes from human newborns Clinical Immunology and Immunopathology  1974 3:79-89  DOI:10.1016/0090-1229(74)90025-7  PMID:4279793
    • Olding, L. B., Oldstone, M. B. Lymphocytes from human newborns abrogate mitosis of their mother's lymphocytes Nature  1974 249:161-162  DOI:10.1038/249161a0  PMID:4275485
    • Lampert, P. W., Oldstone, M. B. Pathology of choroid-plexus in spontaneous immune-complex disease and chronic viral-infections Virchows Archiv. Abteilung A, Pathologische Anatomie  1974 363:21-32  DOI:10.1007/bf00432202
    • Oldstone, M. B., Dixon, F. J. Change in susceptibility of c3h-hej mice to lcm virus-infection Journal of Immunology  1973 111:1613-1615  PMID:4583080
    • Oldstone, M. B., Tishon, A., Chiller, J. M., Weigle, W. O., Dixon, F. J. Effect of chronic viral-infection on immune system .1. Comparison of immune responsiveness of mice chronically infected with lcm virus with that of noninfected mice Journal of Immunology  1973 110:1268-1278  PMID:4121421
    • Oldstone, M. B., Dixon, F. J., Mitchell, G. F., McDevitt, H. O. Histocompatibility-linked genetic-control of disease susceptibility - murine lymphocytic choriomeningitis virus-infection Journal of Experimental Medicine  1973 137:1201-1212  DOI:10.1084/jem.137.5.1201  PMID:4702099
    • Lampert, P. W., Oldstone, M. B. Host immunoglobulin-g and complement deposits in choroid-plexus during spontaneous immune complex disease Science  1973 180:408-410  DOI:10.1126/science.180.4084.408  PMID:4267048
    • Oldstone, M. B., Yamazaki, S., Niwa, A., Notkins, A. L. In vitro detection of cells infected with lactic dehydrogenase virus (LDV) by fluorescein-labeled antibody to LDV Intervirology  1973 2:261-265  DOI:10.1159/000149431  PMID:4604591
    • Oldstone, M. B., Dixon, F. J. Disease accompanying in utero viral infection. The role of maternal antibody in tissue injury after transplacental infection with lymphocytic choriomeningitis virus Journal of Experimental Medicine  1972 135:827-838  DOI:10.1084/jem.135.4.827  PMID:4259667  PMCID:PMC2139158
    • Oldstone, M. B., Dixon, F. J. Inhibition of antibodies to nuclear antigen and to DNA in new zealand mice infected with lactate dehydrogenase virus Science  1972 175:784-786  DOI:10.1126/science.175.4023.784  PMID:4536694
    • Oldstone, M. B., Aoki, T., Dixon, F. J. The antibody response of mice to murine leukemia virus in spontaneous infection: Absence of classical immunologic tolerance (akr mice-complement-fixing antibodies-lymphocytic choriomeningitis virus-immunofluorescence-glomerular deposits of antigen-antibody complexes) Proceedings of the National Academy of Sciences of the United States of America  1972 69:134-138  DOI:10.1073/pnas.69.1.134  PMID:4550501  PMCID:PMC427561
    • Oldstone, M. B., Aoki, T., Dixon, F. J. Activation of spontaneous murine leukemia virus-related antigen by lymphocytic choriomeningitis virus Science  1971 174:843-845  DOI:10.1126/science.174.4011.843  PMID:4330471
    • Oldstone, M. B., Dixon, F. J. Acute viral infection: Tissue injury mediated by anti-viral antibody through a complement effector system Journal of Immunology  1971 107:1274-1280  PMID:5000724
    • Oldstone, M. B. Autoimmunity and viruses--fact or fiction: Persistent lcm viral infection, anti-lcm viral immune response, and tissue injury American Journal of Clinical Pathology  1971 56:299-302  PMID:5094495
    • Lerner, R. A., Oldstone, M. B., Cooper, N. R. Cell cycle-dependent immune lysis of moloney virus-transformed lymphocytes: Presence of viral antigen, accessibility to antibody, and complement activation Proceedings of the National Academy of Sciences of the United States of America  1971 68:2584-2588  DOI:10.1073/pnas.68.10.2584  PMID:4944633  PMCID:PMC389473
    • Oldstone, M. B., Dixon, F. J. Immune complex disease in chronic viral infections Journal of Experimental Medicine  1971 134:32-40  PMID:19867377  PMCID:PMC2139060
    • Oldstone, M. B., Dixon, F. J. Lactic dehydrogenase virus-induced immune complex type of glomerulonephritis Journal of Immunology  1971 106:1260-1263  PMID:4102403
    • Dixon, F. J., Oldstone, M. B., Tonietti, G. Pathogenesis of immune complex glomerulonephritis of new zealand mice Journal of Experimental Medicine  1971 134:65-71  PMID:19867382  PMCID:PMC2139082
    • Oldstone, M. B., Dixon, F. J. Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. Ii. Relationship of the anti-lymphocytic choriomeningitis immune response to tissue injury in chronic lymphocytic choriomeningitis disease Journal of Experimental Medicine  1970 131:1-19  DOI:10.1084/jem.131.1.1  PMID:5460613  PMCID:PMC2138769
    • Oldstone, M. B., Dixon, F. J. Persistent lymphocytic choriomeningitis viral infection. 3. Virus-anti-viral antibody complexes and associated chronic disease following transplacental infection Journal of Immunology  1970 105:829-837  PMID:4990436
    • Tonietti, G., Oldstone, M. B., Dixon, F. J. The effect of induced chronic viral infections on the immunologic diseases of new zealand mice Journal of Experimental Medicine  1970 132:89-109  DOI:10.1084/jem.132.1.89  PMID:4323748  PMCID:PMC2138747
    • Oldstone, M. B., Dixon, F. J. Tissue injury in lymphocytic choriomeningitis viral infection: Virus-induced immunologically specific release of a cytotoxic factor from immune lymphoid cells Virology  1970 42:805-813  DOI:10.1016/0042-6822(70)90330-2  PMID:4992354
    • Sutton, G. G., Oldstone, M. B. Evidence against pyridoxine deficiency as mechanism of penicillin seizures Neurology  1969 19:859-864  PMID:5816879
    • Oldstone, M. B., Dixon, F. J. Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. I. Relationship of antibody production to disease in neonatally infected mice Journal of Experimental Medicine  1969 129:483-505  DOI:10.1084/jem.129.3.483  PMID:4179834  PMCID:PMC2138618
    • Dixon, F. J., Oldstone, M. B., Tonietti, G. Virus-induced immune-complex-type glomerulonephritis Transplantation Proceedings  1969 1:945-948  PMID:4939689
    • Oldstone, M. B., Dixon, F. J. Direct immunofluorescent tissue culture assay for lymphocytic choriomeningitis virus Journal of Immunology  1968 100:1135-1138  PMID:4967592
    • Oldstone, M. B., Dixon, F. J. Immunohistochemical study of allergic encephalomyelitis American Journal of Pathology  1968 52:251-263  PMID:4169739  PMCID:PMC2013335
    • Oldstone, M. B., Dixon, F. J. Susceptibility of different mouse strains to lymphocytic choriomeningitis virus Journal of Immunology  1968 100:355-357  PMID:4966455
    • Oldstone, M. B., Dixon, F. J. Lymphocytic choriomeningitis: Production of antibody by "tolerant" infected mice Science  1967 158:1193-1195  DOI:10.1126/science.158.3805.1193  PMID:4862090
    • Oldstone, M. B. Hospital-acquired staphylococcal infection. Role of airborne organisms. 9-Month review of all admissions and surgical procedures American Surgeon  1966 32:391-394  PMID:5929671
    • Oldstone, M. B., Nelson, E. Central nervous system manifestations of penicillin toxicity in man Neurology  1966 16:693-700  DOI:10.1212/WNL.16.7.693  PMID:5949436
    • Oldstone, M. B. Disturbance of pituitary-adrenal interrelationships in benign intracranial hypertension (pseudotumor cerebri) Journal of Clinical Endocrinology & Metabolism  1966 26:1366-1369  DOI:10.1210/jcem-26-12-1366  PMID:4289594
    • Oldstone, M. B. The endocrinological aspects of benign intracranial hypertension Archives of Neurology  1966 15:362-366  DOI:10.1001/archneur.1966.00470160028004  PMID:4287942
    • Wood, W. H., Oldstone, M., Schultz, R. B. A re-evaluation of blood culture as an autopsy procedure American Journal of Clinical Pathology  1965 43:241-247  PMID:14270966
    • Israel, J., Oldstone, M., Levenson, S., Frank, E. D., Fine, J. Mechanism of action of staphylococcal toxin in rabbits Proceedings of the Society for Experimental Biology and Medicine  1961 108:709-711  DOI:10.3181/00379727-108-27043
    • Wisseman, C. L., Oldstone, M. B., Pazourek, L., Boccuti, A., James, H. Studies on rickettsial toxins. V. Dissimilarity between action of rickettsial mouse lethal toxin and bacterial endotoxin in mice Journal of Immunology  1961 86:613-617  PMID:13786026
    • Oldstone, M. B. A. Altered reactivity to Escherichia coli endotoxin of mice subjected to sub-lethal tourniquet treatment Proceedings of the Society for Experimental Biology and Medicine  1959 102:256-258  DOI:10.3181/00379727-102-25211  PMID:14428624
  • chapter

    • Oldstone, M. B. A. An odyssey to viral pathogenesis Annual Review of Pathology: Mechanisms of Disease, Vol 11. 1-19. 2016  DOI:10.1146/annurev-pathol-012615-044107
    • Rall, G. F., Oldstone, M. B. A. Virus-neuron-cytotoxic T lymphocyte interactions HIV and Dementia. 261-273. 1995

editor of

  • chapter

    • Chemical and genetic tools to explore S1P biology Sphingosine-1-phosphate signaling in immunology and infectious diseases. 55-83. 2014
  • edited book

    • Oldstone, M. B. A., Rosen, H., eds. Sphingosine-1-phosphate signaling in immunology and infectious diseases Current Topics in Microbiology and Immunology. 2014

featured in

  • A New Twist on the Mad Cow: Scientists at The Scripps Research Institute Discover the Normal Prion Protein May Contribute Directly to Disease  News Release
  • Profile of Michael B. A. Oldstone (PNAS)  Article
  • Team Discovers Treatable Mechanism Responsible for Often Deadly Response to Flu  Newsletter
  • Three Scripps Research Scientists Elected to National Academy of Sciences  News Release
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Research

research overview

  • Viral Pathogenesis

    The Viral-Immunobiology Laboratory, under the direction of Michael Oldstone, is interested in understanding the molecular basis of how viruses infect cells, how the immune response aborts viruses, how viruses wrestle control away from the immune system to establish persistent infections, how persistent infection is initiated and maintained, and the mechanism of how such infections cause disease. Because viruses have different lifestyles, our studies focus on lessons taught primarily to three negative-strand viruses, lymphocytic choriomeningitis, measles and influenza viruses, and their interactions with the host's immune, nervous, and pulmonary system. The laboratory is also involved in prion disease pathogenesis.

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Background

education and training

  • M.D. in Medicine, University of Maryland, College Park , School of Medicine 1961
  • Ph.D. in Biochemistry, Johns Hopkins University , Pratt Institute of Biochemistry, M.D./Ph.D. program 1959
  • B.A. in English and History, The University of Alabama (Tuscaloosa) 1954

awards and honors

  • Gallo Award, conferred by Global Virus Network, 2018
  • Member (National Academy of Sciences), conferred by National Academy of Sciences, 2008
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Contact

full name

  • Michael B. Oldstone

geographic location

  • Scripps California 

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