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Nirschl, David
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Nirschl, David

Graduate Student
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Positions

  • 2019 - Head Business Partner, Medical IT, Bristol-Myers Squibb
  • 2016 - 2019 Head Business Partner, Chemistry IT, Bristol-Myers Squibb
  • 2000 - 2015 Senior Principal Scientist, Bristol-Myers Squibb

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Publications

recent publications
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  • academic article

    • Neil, W., Zipp, G., Nemeth, G., Russo, M. F., Nirschl, D. S. End-to-end sample tracking in the laboratory using a custom internet of things device SLAS Technology  2018 23:412-422  DOI:10.1177/2472630318783979  PMID:30016131
    • Kheirabadi, M., Creech, G. S., Qiao, J. X., Nirschl, D. S., Leahy, D. K., Boy, K. M., Carter, P. H., Eastgate, M. D. Leveraging a “catch-release" logic gate process for the synthesis and nonchromatographic purification of thioether- or amine-bridged macrocyclic peptides Journal of Organic Chemistry  2018 83:4323-4335  DOI:10.1021/acs.joc.7b03124  PMID:29537839
    • Jurica, E. A., Wu, X., Williams, K. N., Hernandez, A. S., Nirschl, D. S., Rampulla, R. A., Mathur, A., Zhou, M., Cao, G., Xie, C., Jacob, B., Cai, H., et al. Discovery of pyrrolidine-containing GPR40 agonists: stereochemistry effects a change in binding mode Journal of Medicinal Chemistry  2017 60:1417-1431  DOI:10.1021/acs.jmedchem.6b01559  PMID:28112924
    • Wang, Y., Yang, W., Finlay, H. J., Harikrishnan, L. S., Jiang, J., Kamau, M. G., Van Kirk, K., Nirschl, D. S., Taylor, D. S., Chen, A. Y., Yin, X., Sleph, P. G., et al. Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors Bioorganic & Medicinal Chemistry Letters  2014 24:860-864  DOI:10.1016/j.bmcl.2013.12.088  PMID:24424134
    • Duan, J. J., Lu, Z., Jiang, B., Yang, B. V., Doweyko, L. M., Nirschl, D. S., Haque, L. E., Lin, S., Brown, G., Hynes Jr., J., Tokarski, J. S., Sack, J. S., et al. Discovery of pyrrolo 1,2-b pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors Bioorganic & Medicinal Chemistry Letters  2014 24:5721-5726  DOI:10.1016/j.bmcl.2014.10.061  PMID:25453808
    • Russo, M. F., Wild, D., Hoffman, S., Paulson, J., Neil, W., Nirschl, D. S. A computational method for planning complex compound distributions under container, liquid handler, and assay constraints JALA: Journal of Laboratory Automation  2013 18:391-403  DOI:10.1177/2211068213486651  PMID:23603752
    • Sheppeck, J. E., Gilmore, J. L., Xiao, H. Y., Dhar, T. G. M., Nirschl, D., Doweyko, A. M., Sack, J. S., Corbett, M. J., Malley, M. F., Gougoutas, J. Z., McKay, L., Cunningham, M. D., et al. Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists Bioorganic & Medicinal Chemistry Letters  2013 23:5442-5447  DOI:10.1016/j.bmcl.2013.06.089  PMID:23953070
    • Miller, M. M., Liu, Y., Jiang, J., Johnson, J. A., Kamau, M., Nirschl, D. S., Wang, Y., Harikrishnan, L., Taylor, D. S., Chen, A. Y. A., Yin, X., Seethala, R., et al. Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors Bioorganic & Medicinal Chemistry Letters  2012 22:6503-6508  DOI:10.1016/j.bmcl.2012.08.011  PMID:22995620
    • Weller, H. N., Nirschl, D. S., Paulson, J. L., Hoffman, S. L., Bullock, W. H. Addressing the medicinal chemistry bottleneck: a lean approach to centralized purification ACS Combinatorial Science  2012 14:520-526  DOI:10.1021/co300075g  PMID:22909004
    • Harikrishnan, L. S., Finlay, H. J., Qiao, J. X., Kamau, M. G., Jiang, J., Wang, T. C., Li, J., Cooper, C. B., Poss, M. A., Adam, L. P., Taylor, D. S., Chen, A. Y. A., et al. Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors Journal of Medicinal Chemistry  2012 55:6162-6175  DOI:10.1021/jm300611v  PMID:22650305
    • Harikrishnan, L. S., Srivastava, N., Kayser, L. E., Nirschl, D. S., Kumaragurubaran, K., Roy, A., Gupta, A., Karmakar, S., Karatt, T., Mathur, A., Burford, N. T., Chen, J., et al. Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1) Bioorganic & Medicinal Chemistry Letters  2012 22:2287-2290  DOI:10.1016/j.bmcl.2012.01.082  PMID:22365758
    • Watterson, S. H., Langevine, C. M., Van Kirk, K., Kempson, J., Guo, J., Spergel, S. H., Das, J., Moquin, R. V., Dyckman, A. J., Nirschl, D., Gregor, K., Pattoli, M. A., et al. Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066) Bioorganic & Medicinal Chemistry Letters  2011 21:7006-7012  DOI:10.1016/j.bmcl.2011.09.111  PMID:22018461
    • Harikrishnan, L. S., Kamau, M. G., Wan, H., Inghrim, J. A., Zimmermann, K., Sang, X., Mastalerz, H. A., Johnson, W. L., Zhang, G., Lombardo, L. J., Poss, M. A., Trainor, G. L., et al. Pyrrolo[1,2-f]triazines as JAK2 inhibitors: achieving potency and selectivity for JAK2 over JAK3 Bioorganic & Medicinal Chemistry Letters  2011 21:1425-1428  DOI:10.1016/j.bmcl.2011.01.022  PMID:21282055
    • Dyckman, A. J., Langevine, C. M., Quesnelle, C., Kempson, J., Guo, J., Gill, P., Spergel, S. H., Watterson, S. H., Li, T., Nirschl, D. S., Gillooly, K. M., Pattoli, M. A., et al. Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis Bioorganic & Medicinal Chemistry Letters  2011 21:383-386  DOI:10.1016/j.bmcl.2010.10.133  PMID:21087862
    • Weller, H. N., Ebinger, K., Bullock, W., Edinger, K. J., Hermsmeier, M. A., Hoffman, S. L., Nirschl, D. S., Swann, T., Zhao, J. A., Kiplinger, J., Lefebvre, P. Orthogonality of SFC versus HPLC for small molecule library separation Journal of Combinatorial Chemistry  2010 12:877-882  DOI:10.1021/cc100118y  PMID:20923153
    • Han, Y., Ebinger, K., Vandevier, L. E., Maloney, J. W., Nirschl, D. S., Weller, H. N. Efficient and library-friendly synthesis of furo- and thieno 2,3-d pyrimidin-4-amine derivatives by microwave irradiation Tetrahedron Letters  2010 51:629-632  DOI:10.1016/j.tetlet.2009.11.071
    • Kempson, J., Spergel, S. H., Guo, J., Quesnelle, C., Gill, P., Belanger, D., Dyckman, A. J., Li, T., Watterson, S. H., Langevine, C. M., Das, J., Moquin, R. V., et al. Novel tricyclic inhibitors of IκB kinase Journal of Medicinal Chemistry  2009 52:1994-2005  DOI:10.1021/jm8015816  PMID:19267461
    • Nirschl, D. S., Hermsmeier, M. A., Silber, G., Logan, J. V., Hammar, R., Young, D. L. Enhancing the reagent selection workflow via real-time vendor inventory Journal of Combinatorial Chemistry  2009 11:206-209  DOI:10.1021/cc8001603  PMID:19053504
    • Wang, H., Ruan, Z., Li, J. J., Simpkins, L. M., Smirk, R. A., Wu, S. C., Hutchins, R. D., Nirschl, D. S., Van Kirk, K., Cooper, C. B., Sutton, J. C., Ma, Z., et al. Pyridine amides as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 Bioorganic & Medicinal Chemistry Letters  2008 18:3168-3172  DOI:10.1016/j.bmcl.2008.04.069  PMID:18485702
    • Harikrishnan, L. S., Kamau, M. G., Herpin, T. F., Morton, G. C., Liu, Y., Cooper, C. B., Salvati, M. E., Qiao, J. X., Wang, T. C., Adam, L. P., Taylor, D. S., Chen, A. Y. A., et al. 2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis Bioorganic & Medicinal Chemistry Letters  2008 18:2640-2644  DOI:10.1016/j.bmcl.2008.03.030  PMID:18374566
    • Schroeder, G. M., Chen, X. T., Williams, D. K., Nirschl, D. S., Cai, Z. W., Wei, D., Tokarski, J. S., An, Y. M., Sack, J., Chen, Z., Huynh, T., Vaccaro, W. N., et al. Identification of pyrrolo[2,1-f][1,2,4] triazine-based inhibitors of Met kinase Bioorganic & Medicinal Chemistry Letters  2008 18:1945-1951  DOI:10.1016/j.bmcl.2008.01.121  PMID:18289854
    • Dhar, T. G. M., Wrobleski, S. T., Lin, S., Furch, J. A., Nirschl, D. S., Fan, Y., Todderud, G., Pitt, S., Doweyko, A. M., Sack, J. S., Mathur, A., McKinnon, M., et al. Synthesis and SAR of p38 alpha MAP kinase inhibitors based on heterobicyclic scaffolds Bioorganic & Medicinal Chemistry Letters  2007 17:5019-5024  DOI:10.1016/j.bmcl.2007.07.029  PMID:17664068
    • Weller, H. N., Nirschl, D. S., Petrillo, E. W., Poss, M. A., Andres, C. J., Cavallaro, C. L., Echols, M. M., Grant-Young, K. A., Houston, J. G., Miller, A. V., Swann, R. T. Application of lean manufacturing concepts to drug discovery: Rapid analogue library synthesis Journal of Combinatorial Chemistry  2006 8:664-669  DOI:10.1021/cc050164h  PMID:16961404
    • Martin, M., Smith, D. K., Nirschl, D. S. A Web-based instrument monitoring system JALA (Charlottesville, Va.)  2004 9:398-403  DOI:10.1016/j.jala.2004.07.004
    • degree-related publication Gypser, A., Michel, D., Nirschl, D. S., Sharpless, K. B. Dihydroxylation of polyenes using narasaka's modification of the upjohn procedure Journal of Organic Chemistry  1998 63:7322-7327  DOI:10.1021/jo980850l  PMID:11672379
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 1994 - 2000
  • B.S. in Chemistry, University of Illinois at Urbana-Champaign 1990 - 1994

advisee of

  • graduate advising relationship

    • Sharpless, K. Barry, Ph.D.  candidacy, 1995 - 2000
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Contact

full name

  • David S Nirschl

geographic location

  • Scripps California 

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