recent publications
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academic article
- Neil, W., Zipp, G., Nemeth, G., Russo, M. F., Nirschl, D. S. End-to-end sample tracking in the laboratory using a custom internet of things device SLAS Technology 2018 23:412-422 DOI:10.1177/2472630318783979 PMID:30016131
- Kheirabadi, M., Creech, G. S., Qiao, J. X., Nirschl, D. S., Leahy, D. K., Boy, K. M., Carter, P. H., Eastgate, M. D. Leveraging a “catch-release" logic gate process for the synthesis and nonchromatographic purification of thioether- or amine-bridged macrocyclic peptides Journal of Organic Chemistry 2018 83:4323-4335 DOI:10.1021/acs.joc.7b03124 PMID:29537839
- Jurica, E. A., Wu, X., Williams, K. N., Hernandez, A. S., Nirschl, D. S., Rampulla, R. A., Mathur, A., Zhou, M., Cao, G., Xie, C., Jacob, B., Cai, H., et al. Discovery of pyrrolidine-containing GPR40 agonists: stereochemistry effects a change in binding mode Journal of Medicinal Chemistry 2017 60:1417-1431 DOI:10.1021/acs.jmedchem.6b01559 PMID:28112924
- Wang, Y., Yang, W., Finlay, H. J., Harikrishnan, L. S., Jiang, J., Kamau, M. G., Van Kirk, K., Nirschl, D. S., Taylor, D. S., Chen, A. Y., Yin, X., Sleph, P. G., et al. Diphenylpyridylethanamine (DPPE)-based aminoheterocycles as cholesteryl ester transfer protein inhibitors Bioorganic & Medicinal Chemistry Letters 2014 24:860-864 DOI:10.1016/j.bmcl.2013.12.088 PMID:24424134
- Duan, J. J., Lu, Z., Jiang, B., Yang, B. V., Doweyko, L. M., Nirschl, D. S., Haque, L. E., Lin, S., Brown, G., Hynes Jr., J., Tokarski, J. S., Sack, J. S., et al. Discovery of pyrrolo 1,2-b pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors Bioorganic & Medicinal Chemistry Letters 2014 24:5721-5726 DOI:10.1016/j.bmcl.2014.10.061 PMID:25453808
- Russo, M. F., Wild, D., Hoffman, S., Paulson, J., Neil, W., Nirschl, D. S. A computational method for planning complex compound distributions under container, liquid handler, and assay constraints JALA: Journal of Laboratory Automation 2013 18:391-403 DOI:10.1177/2211068213486651 PMID:23603752
- Sheppeck, J. E., Gilmore, J. L., Xiao, H. Y., Dhar, T. G. M., Nirschl, D., Doweyko, A. M., Sack, J. S., Corbett, M. J., Malley, M. F., Gougoutas, J. Z., McKay, L., Cunningham, M. D., et al. Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists Bioorganic & Medicinal Chemistry Letters 2013 23:5442-5447 DOI:10.1016/j.bmcl.2013.06.089 PMID:23953070
- Weller, H. N., Nirschl, D. S., Paulson, J. L., Hoffman, S. L., Bullock, W. H. Addressing the medicinal chemistry bottleneck: a lean approach to centralized purification ACS Combinatorial Science 2012 14:520-526 DOI:10.1021/co300075g PMID:22909004
- Harikrishnan, L. S., Finlay, H. J., Qiao, J. X., Kamau, M. G., Jiang, J., Wang, T. C., Li, J., Cooper, C. B., Poss, M. A., Adam, L. P., Taylor, D. S., Chen, A. Y. A., et al. Diphenylpyridylethanamine (DPPE) derivatives as cholesteryl ester transfer protein (CETP) inhibitors Journal of Medicinal Chemistry 2012 55:6162-6175 DOI:10.1021/jm300611v PMID:22650305
- Harikrishnan, L. S., Srivastava, N., Kayser, L. E., Nirschl, D. S., Kumaragurubaran, K., Roy, A., Gupta, A., Karmakar, S., Karatt, T., Mathur, A., Burford, N. T., Chen, J., et al. Identification and optimization of small molecule antagonists of vasoactive intestinal peptide receptor-1 (VIPR1) Bioorganic & Medicinal Chemistry Letters 2012 22:2287-2290 DOI:10.1016/j.bmcl.2012.01.082 PMID:22365758
- Miller, M. M., Liu, Y., Jiang, J., Johnson, J. A., Kamau, M., Nirschl, D. S., Wang, Y., Harikrishnan, L., Taylor, D. S., Chen, A. Y. A., Yin, X., Seethala, R., et al. Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors Bioorganic & Medicinal Chemistry Letters 2012 22:6503-6508 DOI:10.1016/j.bmcl.2012.08.011 PMID:22995620
- Dyckman, A. J., Langevine, C. M., Quesnelle, C., Kempson, J., Guo, J., Gill, P., Spergel, S. H., Watterson, S. H., Li, T., Nirschl, D. S., Gillooly, K. M., Pattoli, M. A., et al. Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis Bioorganic & Medicinal Chemistry Letters 2011 21:383-386 DOI:10.1016/j.bmcl.2010.10.133 PMID:21087862
- Watterson, S. H., Langevine, C. M., Van Kirk, K., Kempson, J., Guo, J., Spergel, S. H., Das, J., Moquin, R. V., Dyckman, A. J., Nirschl, D., Gregor, K., Pattoli, M. A., et al. Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066) Bioorganic & Medicinal Chemistry Letters 2011 21:7006-7012 DOI:10.1016/j.bmcl.2011.09.111 PMID:22018461
- Harikrishnan, L. S., Kamau, M. G., Wan, H., Inghrim, J. A., Zimmermann, K., Sang, X., Mastalerz, H. A., Johnson, W. L., Zhang, G., Lombardo, L. J., Poss, M. A., Trainor, G. L., et al. Pyrrolo[1,2-f]triazines as JAK2 inhibitors: achieving potency and selectivity for JAK2 over JAK3 Bioorganic & Medicinal Chemistry Letters 2011 21:1425-1428 DOI:10.1016/j.bmcl.2011.01.022 PMID:21282055
- Han, Y., Ebinger, K., Vandevier, L. E., Maloney, J. W., Nirschl, D. S., Weller, H. N. Efficient and library-friendly synthesis of furo- and thieno 2,3-d pyrimidin-4-amine derivatives by microwave irradiation Tetrahedron Letters 2010 51:629-632 DOI:10.1016/j.tetlet.2009.11.071
- Weller, H. N., Ebinger, K., Bullock, W., Edinger, K. J., Hermsmeier, M. A., Hoffman, S. L., Nirschl, D. S., Swann, T., Zhao, J. A., Kiplinger, J., Lefebvre, P. Orthogonality of SFC versus HPLC for small molecule library separation Journal of Combinatorial Chemistry 2010 12:877-882 DOI:10.1021/cc100118y PMID:20923153
- Nirschl, D. S., Hermsmeier, M. A., Silber, G., Logan, J. V., Hammar, R., Young, D. L. Enhancing the reagent selection workflow via real-time vendor inventory Journal of Combinatorial Chemistry 2009 11:206-209 DOI:10.1021/cc8001603 PMID:19053504
- Kempson, J., Spergel, S. H., Guo, J., Quesnelle, C., Gill, P., Belanger, D., Dyckman, A. J., Li, T., Watterson, S. H., Langevine, C. M., Das, J., Moquin, R. V., et al. Novel tricyclic inhibitors of IκB kinase Journal of Medicinal Chemistry 2009 52:1994-2005 DOI:10.1021/jm8015816 PMID:19267461
- Harikrishnan, L. S., Kamau, M. G., Herpin, T. F., Morton, G. C., Liu, Y., Cooper, C. B., Salvati, M. E., Qiao, J. X., Wang, T. C., Adam, L. P., Taylor, D. S., Chen, A. Y. A., et al. 2-Arylbenzoxazoles as novel cholesteryl ester transfer protein inhibitors: optimization via array synthesis Bioorganic & Medicinal Chemistry Letters 2008 18:2640-2644 DOI:10.1016/j.bmcl.2008.03.030 PMID:18374566
- Schroeder, G. M., Chen, X. T., Williams, D. K., Nirschl, D. S., Cai, Z. W., Wei, D., Tokarski, J. S., An, Y. M., Sack, J., Chen, Z., Huynh, T., Vaccaro, W. N., et al. Identification of pyrrolo[2,1-f][1,2,4] triazine-based inhibitors of Met kinase Bioorganic & Medicinal Chemistry Letters 2008 18:1945-1951 DOI:10.1016/j.bmcl.2008.01.121 PMID:18289854
- Wang, H., Ruan, Z., Li, J. J., Simpkins, L. M., Smirk, R. A., Wu, S. C., Hutchins, R. D., Nirschl, D. S., Van Kirk, K., Cooper, C. B., Sutton, J. C., Ma, Z., et al. Pyridine amides as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 Bioorganic & Medicinal Chemistry Letters 2008 18:3168-3172 DOI:10.1016/j.bmcl.2008.04.069 PMID:18485702
- Dhar, T. G. M., Wrobleski, S. T., Lin, S., Furch, J. A., Nirschl, D. S., Fan, Y., Todderud, G., Pitt, S., Doweyko, A. M., Sack, J. S., Mathur, A., McKinnon, M., et al. Synthesis and SAR of p38 alpha MAP kinase inhibitors based on heterobicyclic scaffolds Bioorganic & Medicinal Chemistry Letters 2007 17:5019-5024 DOI:10.1016/j.bmcl.2007.07.029 PMID:17664068
- Weller, H. N., Nirschl, D. S., Petrillo, E. W., Poss, M. A., Andres, C. J., Cavallaro, C. L., Echols, M. M., Grant-Young, K. A., Houston, J. G., Miller, A. V., Swann, R. T. Application of lean manufacturing concepts to drug discovery: Rapid analogue library synthesis Journal of Combinatorial Chemistry 2006 8:664-669 DOI:10.1021/cc050164h PMID:16961404
- Martin, M., Smith, D. K., Nirschl, D. S. A Web-based instrument monitoring system JALA (Charlottesville, Va.) 2004 9:398-403 DOI:10.1016/j.jala.2004.07.004
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Gypser, A., Michel, D., Nirschl, D. S., Sharpless, K. B.
Dihydroxylation of polyenes using narasaka's modification of the upjohn procedure
Journal of Organic Chemistry
1998
63:7322-7327
DOI:10.1021/jo980850l
PMID:11672379