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Niedernhofer, Laura
Publications in VIVO
 
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Niedernhofer, Laura

Faculty Member
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Positions

  • 2017 - 2019 Associate Professor, Molecular Medicine , Scripps Research
  • 2012 - 2019 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2012 - 2017 Associate Professor, Metabolism and Aging , Scripps Research

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Publications

recent publications

  • academic article

    • Han, Y. C., Zhou, C. M., Shen, H. X., Tan, J., Dong, Q., Zhang, L., McGowan, S. J., Zhao, J., Sowa, G. A., Kang, J. D., Niedernhofer, L. J., Robbins, P. D., et al. Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration Aging Cell  2020  DOI:10.1111/acel.13162  PMID:32567210
    • Yousefzadeh, M. J., Wilkinson, J. E., Hughes, B., Gadela, N., Ladiges, W. C., Vo, N., Niedernhofer, L. J., Huffman, D. M., Robbins, P. D. Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues Geroscience  2020 42:951-961  DOI:10.1007/s11357-020-00185-1  PMID:32285290  PMCID:PMC7286998
    • Zhao, J., Zhang, L., Lu, A. P., Han, Y. C., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X. S., Gurkar, A. U., McGowan, S. J., Angelini, L., et al. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging Aging-US  2020 12:4688-4710  DOI:10.18632/aging.102863  PMID:32201398  PMCID:PMC7138542
    • Yousefzadeh, M. J., Zhao, J., Bukata, C., Wade, E. A., McGowan, S. J., Angelini, L. A., Bank, M. P., Gurkar, A. U., McGuckian, C. A., Calubag, M. F., Kato, J. I., Burd, C. E., et al. Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice Aging Cell  2020  DOI:10.1111/acel.13094  PMID:31981461
    • Flores, R. R., Carbo, L., Kim, E., Van Meter, M., De Padilla, C. M. L., Zhao, J., Colangelo, D., Yousefzadeh, M. J., Angelini, L. A., Zhang, L., Pola, E., Vo, N., et al. Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice FASEB Journal  2019 33:9505-9515  DOI:10.1096/fj.201900420R  PMID:31170010  PMCID:PMC6662986
    • Fuhrmann-Stroissnigg, H., Santiago, F. E., Grassi, D., Ling, Y., Niedernhofer, L. J., Robbins, P. D. SA-β-galactosidase-based screening assay for the identification of senotherapeutic drugs Journal of Visualized Experiments : JoVE  2019  DOI:10.3791/58133  PMID:31305507
    • Bell-Temin, H., Yousefzadeh, M. J., Bondarenko, A., Quarles, E., Jones-Laughner, J., Robbins, P. D., Ladiges, W., Niedernhofer, L. J., Yates, N. A. Measuring biological age in mice using differential mass spectrometry Aging-Us  2019 11:1045-1061  DOI:10.18632/aging.101810  PMID:30745468  PMCID:PMC6382423
    • Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., et al. Fisetin is a senotherapeutic that extends health and lifespan EBiomedicine  2018 36:18-28  DOI:10.1016/j.ebiom.2018.09.015  PMID:30279143  PMCID:PMC6197652
    • Gurkar, A. U., Robinson, A. R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P. D., Wang, Y., Kelley, E. E., et al. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging Redox Biology  2018 18:191-199  DOI:10.1016/j.redox.2018.06.005  PMID:30031267  PMCID:PMC6076207
    • Czerwiriska, J., Nowak, M., Wojtczak, P., Dziuban-Lech, D., Ciesla, J. M., Kolata, D., Gajewska, B., Baranczyk-Kuzma, A., Robinson, A. R., Shane, H. L., Gregg, S. Q., Rigatti, L. H., et al. ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation Free Radical Biology and Medicine  2018 124:79-96  DOI:10.1016/j.freeradbiomed.2018.05.088  PMID:29860127  PMCID:PMC6098728
    • Zarakowska, E., Czerwinska, J., Tupalska, A., Yousefzadeh, M. J., Gregg, S. Q., St Croix, C. M., Niedernhofer, L. J., Foksinski, M., Gackowski, D., Szpila, A., Starczak, M., Tudek, B., et al. Oxidation products of 5-methylcytosine are decreased in senescent cells and tissues of progeroid mice Journals of Gerontology Series a-Biological Sciences and Medical Sciences  2018 73:1003-1009  DOI:10.1093/gerona/gly012  PMID:29415265
    • Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., et al. Senolytics improve physical function and increase lifespan in old age Nature Medicine  2018 24:1246-+  DOI:10.1038/s41591-018-0092-9  PMID:29988130  PMCID:PMC6082705
    • Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnsong, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., et al. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging Redox Biology  2018 17:259-273  DOI:10.1016/j.redox.2018.04.007  PMID:29747066  PMCID:PMC6006678
    • Zhao, J., Zhang, L., Mu, X., Doebelin, C., Nguyen, W., Wallace, C., Reay, D. P., McGowan, S. J., Corbo, L., Clemens, P. R., Wilson, G. M., Watkins, S. C., et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation PLoS Biology  2018 16  DOI:10.1371/journal.pbio.2004663  PMID:29889904  PMCID:PMC6013238
    • Niedernhofer, L. J., Robbins, P. D. Senotherapeutics for healthy ageing Nature Reviews Drug Discovery  2018 17  PMID:29651106
    • Yousefzadeh, M. J., Schafer, M. J., Hooten, N. N., Atkinson, E. J., Evans, M. K., Baker, D. J., Quarles, E. K., Robbins, P. D., Ladiges, W. C., LeBrasseur, N. K., Niedernhofer, L. J. Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans Aging Cell  2018 17  DOI:10.1111/acel.12706  PMID:29290100  PMCID:PMC5847863
    • Mori, T., Yousefzadeh, M. J., Faridounnia, M., Chong, J. X., Hisama, F. M., Hudgins, L., Mercado, G., Wade, E. A., Barghouthy, A. S., Lee, L., Martin, G. M., Nickerson, D. A., et al. ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes Human Mutation  2018 39:255-265  DOI:10.1002/humu.23367  PMID:29105242  PMCID:PMC5762268
    • Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D. Hsp90 inhibitors as senolytic drugs to extend healthy aging Cell Cycle  2018 17:1048-1055  DOI:10.1080/15384101.2018.1475828  PMID:29886783  PMCID:PMC6110594
    • Niedernhofer, L. J., Gurkar, A. U., Wang, Y. S., Vijg, J., Hoeijmakers, J. H. J., Robbins, P. D. Nuclear genomic instability and aging Annual Review of Biochemistry  2018 87:295-322  DOI:10.1146/annurev-biochem-062917-012239  PMID:29925262
    • Ngo, K., Pohl, P., Wang, D., Leme, A. S., Lee, J., Di, P., Roughley, P., Robbins, P. D., Niedernhofer, L. J., Sowa, G., Kang, J. D., Shapiro, S. S., et al. ADAMTS5 deficiency protects mice from chronic tobacco smoking-induced intervertebral disc degeneration Spine  2017 42:1521-1528  DOI:10.1097/brs.0000000000002258  PMID:28570296  PMCID:MC5633483
    • Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J., Robbins, P. D. The clinical potential of senolytic drugs Journal of the American Geriatrics Society  2017 65:2297-2301  DOI:10.1111/jgs.14969  PMID:28869295  PMCID:PMC5641223
    • Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., et al. Identification of HSP90 inhibitors as a novel class of senolytics Nature Communications  2017 8  DOI:10.1038/s41467-017-00314-z  PMID:28871086  PMCID:PMC5583353
    • Ngo, K., Patil, P., McGowan, S. J., Niedernhofer, L. J., Robbins, P. D., Kang, J., Sowa, G., Vo, N. Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype Mechanisms of Ageing and Development  2017 166:16-23  DOI:10.1016/j.mad.2017.08.007  PMID:28830687  PMCID:PMC5632945
    • Takayama, K., Kawakami, Y., Lavasani, M., Mu, X., Cummins, J. H., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., Niedernhofer, L. J., Huard, J. mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging Journal of Orthopaedic Research  2017 35:1375-1382  DOI:10.1002/jor.23409  PMID:27572850
    • Robbins, P. D., Niedernhofer, L. J. Advances in therapeutic approaches to extend healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging Aging Cell  2017 16:610-614  DOI:10.1111/acel.12620  PMID:28585366  PMCID:PMC5506446
    • Flores, R. R., Clauson, C. L., Cho, J., Lee, B. C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J., Robbins, P. D. Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism Aging Cell  2017 16:480-487  DOI:10.1111/acel.12571  PMID:28229533  PMCID:PMC5418207
    • Niedernhofer, L. J., Kirkland, J. L., Ladiges, W. Molecular pathology endpoints useful for aging studies Ageing Research Reviews  2017 35:241-249  DOI:10.1016/j.arr.2016.09.012  PMID:27721062  PMCID:PMC5357461
    • Huan, T., Forsberg, E. M., Rinehart, D., Johnson, C. H., Ivanisevic, J., Benton, H. P., Fang, M., Aisporna, A., Hilmers, B., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., et al. Systems biology guided by XCMS Online metabolomics Nature Methods  2017 14:461-462  PMID:28448069
    • Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T., Kirkland, J. L. New agents that target senescent cells: the flavone, fisetin, and the BCL-X-L inhibitors, A1331852 and A1155463 Aging  2017 9:955-963  DOI:10.18632/aging.101202  PMID:28273655  PMCID:PMC5391241
    • Yu, Y., Cui, Y., Niedernhofer, L. J., Wang, Y. Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage Chemical Research in Toxicology  2016 29:2008-2039  DOI:10.1021/acs.chemrestox.6b00265  PMID:27989142
    • Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N., Kirkland, J. L. Barriers to the preclinical development of therapeutics that target aging mechanisms Journals of Gerontology Series A-Biological Sciences and Medical Sciences  2016 71:1388-1394  DOI:10.1093/gerona/glw112  PMID:27535964  PMCID:PMC5055650
    • Montenegro-Burke, J. R., Phommavongsay, T., Aisporna, A. E., Huan, T., Rinehart, D., Forsberg, E., Poole, F. L., Thorgersen, M. P., Adams, M. W., Krantz, G., Fields, M. W., Northen, T. R., et al. Smartphone analytics: mobilizing the lab into the cloud for omicscale analyses Analytical Chemistry  2016 88:9753-9758  DOI:10.1021/acs.analchem.6b02676  PMID:27560777  PMCID:PMC5054939
    • Zhu, Y., Tchkonia, T., Fuhrmann-Stroissnigg, H., Dai, H. M. M., Ling, Y. Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., Wren, J. D., Niedernhofer, L. J., et al. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors Aging Cell  2016 15:428-435  DOI:10.1111/acel.12445  PMID:26711051  PMCID:PMC4854923
    • Ladiges, W., Ikeno, Y., Niedernhofer, L., McIndoe, R. A., Ciol, M. A., Ritchey, J., Liggitt, D. The Geropathology Research Network: An interdisciplinary approach for integrating pathology into research on aging Journals of Gerontology Series A-Biological Sciences and Medical Sciences  2016 71:431-434  DOI:10.1093/gerona/glv079  PMID:26243216  PMCID:PMC5014185
    • Amato, N. J., Zhai, Q., Navarro, D. C., Niedernhofer, L. J., Wang, Y. In vivo detection and replication studies of α-anomeric lesions of 2'-deoxyribonucleosides Nucleic Acids Research  2015 43:8314-8324  DOI:10.1093/nar/gkv725  PMID:26202973  PMCID:PMC4787794
    • Fu, L., Amato, N. J., Wang, P., McGowan, S. J., Niedernhofer, L. J., Wang, Y. Simultaneous quantification of methylated cytidine and adenosine in cellular and tissue RNA by Nano-Flow liquid chromatography-tandem mass spectrometry coupled with the stable isotope-dilution method Analytical Chemistry  2015 87:7653-7659  DOI:10.1021/acs.analchem.5b00951  PMID:26158405  PMCID:PMC4711271
    • Gurkar, A. U., Niedernhofer, L. J. Comparison of mice with accelerated aging caused by distinct mechanisms Experimental Gerontology  2015 68:43-50  DOI:10.1016/j.exger.2015.01.045  PMID:25617508  PMCID:PMC4464936
    • Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O'Hara, S. P., LaRusso, N. F., et al. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs Aging Cell  2015 14:644-658  DOI:10.1111/acel.12344  PMID:25754370  PMCID:PMC4531078
    • Fu, L., Guerrero, C. R., Zhong, N., Amato, N. J., Liu, Y., Liu, S., Cai, Q., Ji, D., Jin, S. G., Niedernhofer, L. J., Pfeifer, G. P., Xu, G. L., et al. Tet-mediated formation of 5-hydroxymethylcytosine in RNA Journal of the American Chemical Society  2014 136:11582-11585  DOI:10.1021/ja505305z  PMID:25073028  PMCID:PMC4140497
    • Nasto, L. A., Ngo, K., Leme, A. S., Robinson, A. R., Dong, Q., Roughley, P., Usas, A., Sowa, G. A., Pola, E., Kang, J., Niedernhofer, L. J., Shapiro, S., et al. Investigating the role of DNA damage in tobacco smoking-induced spine degeneration Spine Journal  2014 14:416-423  DOI:10.1016/j.spinee.2013.08.034  PMID:24211096  PMCID:PMC3944725
    • Tilstra, J. S., Gaddy, D. F., Zhao, J., Dave, S. H., Niedernhofer, L. J., Plevy, S. E., Robbins, P. D. Pharmacologic IKK/NF-kappa B inhibition causes antigen presenting cells to undergo TNF alpha dependent ROS-mediated programmed cell death Scientific Reports  2014 4:3631  DOI:10.1038/srep03631  PMID:24406986  PMCID:PMC3887388
    • Clauson, C., Scharer, O. D., Niedernhofer, L. Advances in understanding the complex mechanisms of DNA interstrand cross-link repair Cold Spring Harbor Perspectives in Biology  2013 5:a012732  DOI:10.1101/cshperspect.a012732  PMID:24086043  PMCID:PMC3783045
    • Karakasilioti, I., Kamileri, I., Chatzinikolaou, G., Kosteas, T., Vergadi, E., Robinson, A. R., Tsamardinos, I., Rozgaja, T. A., Siakouli, S., Tsatsanis, C., Niedernhofer, L. J., Garinis, G. A. DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria Cell Metabolism  2013 18:403-415  DOI:10.1016/j.cmet.2013.08.011  PMID:24011075  PMCID:PMC4116679
    • Vo, N., Niedernhofer, L. J., Nasto, L. A., Jacobs, L., Robbins, P. D., Kang, J., Evans, C. H. An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints Journal of Orthopaedic Research  2013 31:831-837  DOI:10.1002/jor.22204  PMID:23483579  PMCID:PMC3628921
    • You, C. J., Dai, X. X., Yuan, B. F., Wang, J., Wang, J. S., Brooks, P. J., Niedernhofer, L. J., Wang, Y. S. A quantitative assay for assessing the effects of DNA lesions on transcription Nature Chemical Biology  2012 8:817-822  DOI:10.1038/nchembio.1046  PMID:22902614  PMCID:PMC3509257
    • Nasto, L. A., Seo, H. Y., Robinson, A. R., Tilstra, J. S., Clauson, C. L., Sowa, G. A., Ngo, K., Dong, Q., Pola, E., Lee, J. Y., Niedernhofer, L. J., Kang, J. D., et al. Issls prize winner: Inhibition of nf-kappa b activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging Spine  2012 37:1819-1825  DOI:10.1097/BRS.0b013e31824ee8f7  PMID:22343279  PMCID:PMC3395770
    • DeLoia, J. A., Bhagwat, N. R., Darcy, K. M., Strange, M., Tian, C., Nuttall, K., Krivak, T. C., Niedernhofer, L. J. Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum Gynecologic Oncology  2012 126:448-454  DOI:10.1016/j.ygyno.2012.05.006  PMID:22609620  PMCID:PMC3518863
    • Matoka, D. J., Yao, V., Harya, D. S., Gregg, J. L., Robinson, A. R., Niedernhofer, L. J., Parwani, A. V., Maier, C., Bacich, D. J. Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model Prostate  2012 72:1214-1222  DOI:10.1002/pros.22472  PMID:22212909  PMCID:PMC3490419
    • Wang, J., Cao, H. C., You, C. J., Yuan, B. F., Bahde, R., Gupta, S., Nishigori, C., Niedernhofer, L. J., Brooks, P. J., Wang, Y. S. Endogenous formation and repair of oxidatively induced g (8-5m) T intrastrand cross-link lesion Nucleic Acids Research  2012 40:7368-7374  DOI:10.1093/nar/gks357  PMID:22581771  PMCID:PMC3424544
    • Wang, D., Nasto, L. A., Roughley, P., Leme, A. S., Houghton, A. M., Usas, A., Sowa, G., Lee, J., Niedernhofer, L., Shapiro, S., Kang, J., Vo, N. Spine degeneration in a murine model of chronic human tobacco smokers Osteoarthritis and Cartilage  2012 20:896-905  DOI:10.1016/j.joca.2012.04.010  PMID:22531458  PMCID:PMC3389285
    • Wang, J., Clauson, C. L., Robbins, P. D., Niedernhofer, L. J., Wang, Y. S. The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner Aging Cell  2012 11:714-716  DOI:10.1111/j.1474-9726.2012.00828.x  PMID:22530741  PMCID:PMC3399950
    • Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., Huard, J., Clemens, P. R., et al. NF-kB inhibition delays DNA damage-induced senescence and aging in mice Journal of Clinical Investigation  2012 122:2601-2612  DOI:10.1172/jci45785  PMID:22706308  PMCID:PMC3386805
    • Su, Y., Orelli, B., Madireddy, A., Niedernhofer, L. J., Scharer, O. D. Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair Journal of Biological Chemistry  2012 287:21846-21855  DOI:10.1074/jbc.M111.337899  PMID:22547097  PMCID:PMC3381147
    • Rubatt, J. M., Darcy, K. M., Tian, C. Q., Muggia, F., Dhir, R., Armstrong, D. K., Bookman, M. A., Niedernhofer, L. J., Deloia, J., Birrer, M., Krivak, T. C. Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: A gynecologic oncology group study Gynecologic Oncology  2012 125:421-426  DOI:10.1016/j.ygyno.2012.01.008  PMID:22261301  PMCID:PMC3490188
    • Smith, S. C., Robinson, A. R., Niedernhofer, L. J., Hetman, M. Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice Neurobiology of Disease  2012 45:1136-1144  DOI:10.1016/j.nbd.2011.12.036  PMID:22245387  PMCID:PMC3345809
    • Lu, A. P., Proto, J. D., Guo, L. L., Tang, Y., Lavasani, M., Tilstra, J. S., Niedernhofer, L. J., Wang, B., Guttridge, D. C., Robbins, P. D., Huard, J. NF-kB negatively impacts the myogenic potential of muscle-derived stem cells Molecular Therapy  2012 20:661-668  DOI:10.1038/mt.2011.261  PMID:22158056  PMCID:PMC3293604
    • Gregg, S. Q., Gutierrez, V., Robinson, A. R., Woodell, T., Nakao, A., Ross, M. A., Michalopoulos, G. K., Rigatti, L., Rothermel, C. E., Kamileri, I., Garinis, G., Stolz, D. B., et al. A mouse model of accelerated liver aging caused by a defect in DNA repair Hepatology  2012 55:609-621  DOI:10.1002/hep.24713  PMID:21953681  PMCID:PMC3250572
    • Lavasani, M., Robinson, A. R., Lu, A. P., Song, M. J., Feduska, J. M., Ahani, B., Tilstra, J. S., Feldman, C. H., Robbins, P. D., Niedernhofer, L. J., Huard, J. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model Nature Communications  2012 3:608  DOI:10.1038/ncomms1611  PMID:22215083  PMCID:PMC3272577
    • Vaezi, A., Wang, X. Z., Buch, S., Gooding, W., Wang, L., Seethala, R. R., Weaver, D. T., D'Andrea, A. D., Argiris, A., Romkes, M., Niedernhofer, L. J., Grandis, J. R. XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck Clinical Cancer Research  2011 17:5513-5522  DOI:10.1158/1078-0432.ccr-11-0086  PMID:21737503  PMCID:PMC3156890
    • Goss, J. R., Stolz, D. B., Robinson, A. R., Zhang, M. D., Arbujas, N., Robbins, P. D., Glorioso, J. C., Niedernhofer, L. J. Premature aging-related peripheral neuropathy in a mouse model of progeria Mechanisms of Ageing and Development  2011 132:437-442  DOI:10.1016/j.mad,2011.04.010  PMID:21596054  PMCID:PMC3179831
    • Gregg, S. Q., Robinson, A. R., Niedernhofer, L. J. Physiological consequences of defects in ercc1-xpf DNA repair endonuclease DNA Repair  2011 10:781-791  DOI:10.1016/j.dnarep.2011.04.026  PMID:21612988  PMCID:PMC3139823
    • Wang, D., Vo, N. V., Sowa, G. A., Hartman, R. A., Ngo, K., Choe, S. R., Witt, W. T., Dong, Q., Lee, J. Y., Niedernhofer, L. J., Kang, J. D. Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system Spine Journal  2011 11:139-146  DOI:10.1016/j.spinee.2010.11.017  PMID:21296298  PMCID:PMC3056334
    • Vo, N., Seo, H. Y., Robinson, A., Sowa, G., Bentley, D., Taylor, L., Studer, R., Usas, A., Huard, J., Alber, S., Watkins, S. C., Lee, J., et al. Accelerated aging of intervertebral discs in a mouse model of progeria Journal of Orthopaedic Research  2010 28:1600-1607  DOI:10.1002/jor.21153  PMID:20973062  PMCID:PMC3477798
    • Hagelstrom, R. T., Blagoev, K. B., Niedernhofer, L. J., Goodwin, E. H., Bailey, S. M. Hyper telomere recombination accelerates replicative senescence and may promote premature aging Proceedings of the National Academy of Sciences of the United States of America  2010 107:15768-15773  DOI:10.1073/pnas.1006338107  PMID:20798040  PMCID:PMC2936608
    • Ahmad, A., Enzlin, J. H., Bhagwat, N. R., Wijgers, N., Raams, A., Appledoorn, E., Theil, A. F., Hoeijmakers, J. H. J., Vermeulen, W., Jaspers, N. G. J., Scharer, O. D., Niedernhofer, L. J. Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients PLoS Genetics  2010 6:e1000871  DOI:10.1371/journal.pgen.1000871  PMID:20221251  PMCID:PMC2832669
    • Orelli, B., McClendon, T. B., Tsodikov, O. V., Ellenberger, T., Niedernhofer, L. J., Scharer, O. D. The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways Journal of Biological Chemistry  2010 285:3705-3712  DOI:10.1074/jbc.M109.067538  PMID:19940136  PMCID:PMC2823511
    • Bhagwat, N., Olsen, A. L., Wang, A. T., Hanada, K., Stuckert, P., Kanaar, R., D'Andrea, A., Niedernhofer, L. J., McHugh, P. J. XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair Molecular and Cellular Biology  2009 29:6427-6437  DOI:10.1128/mcb.00086-09  PMID:19805513  PMCID:PMC2786876
    • Bhagwat, N. R., Roginskaya, V. Y., Acquafondata, M. B., Dhir, R., Wood, R. D., Niedernhofer, L. J. Immunodetection of DNA repair endonuclease ERCC1-XPF in human tissue Cancer Research  2009 69:6831-6838  DOI:10.1158/0008-5472.can-09-1237  PMID:19723666  PMCID:PMC2739111
    • Parmar, K., D'Andrea, A., Niedernhofer, L. J. Mouse models of fanconi anemia Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis  2009 668:133-140  DOI:10.1016/j.mrfmmm.2009.03.015  PMID:19427003  PMCID:PMC2778466
    • Schumacher, B., van der Pluijm, I., Moorhouse, M. J., Kosteas, T., Robinson, A. R., Suh, Y., Breit, T. M., van Steeg, H., Niedernhofer, L. J., van Ijcken, W., Bartke, A., Spindler, S. R., et al. Delayed and accelerated aging share common longevity assurance mechanisms PLoS Genetics  2008 4:e1000161  DOI:10.1371/journal.pgen.1000161  PMID:18704162  PMCID:PMC2493043
    • Ahmad, A., Robinson, A. R., Duensing, A., van Drunen, E., Beverloo, H. B., Weisberg, D. B., Hasty, P., Hoeijmakers, J. H. J., Niedernhofer, L. J. ERCC1-XPF endonuclease facilitates DNA double-strand break repair Molecular and Cellular Biology  2008 28:5082-5092  DOI:10.1128/mcb.00293-08  PMID:18541667  PMCID:PMC2519706
    • Niedernhofer, L. J. Nucleotide excision repair deficient mouse models and neurological disease DNA Repair  2008 7:1180-1189  DOI:10.1016/j.dnarep.2007.12.006  PMID:18272436  PMCID:PMC2474780
    • Niedernhofer, L. J. Tissue-specific accelerated aging in nucleotide excision repair deficiency Mechanisms of Ageing and Development  2008 129:408-415  DOI:10.1016/j.mad.2008.04.010  PMID:18538374  PMCID:PMC2518655
    • Niedernhofer, L. J. DNA repair is crucial for maintaining hematopoietic stem cell function DNA Repair  2008 7:523-529  DOI:10.1016/j.dnarep.2007.11.012  PMID:18248857  PMCID:PMC2731414
    • Jaspers, N. G. J., Raams, A., Silengo, M. C., Wijgers, N., Niedernhofer, L. J., Robinson, A. R., Giglia-Mari, G., Hoogstraten, D., Kleijer, W. J., Hoeijmakers, J. H. J., Vermeulen, W. First reported patient with human ercc1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure American Journal of Human Genetics  2007 80:457-466  DOI:10.1086/512486  PMID:17273966  PMCID:PMC1821117
    • van der Pluijm, I., Garinis, G. A., Brandt, R. M. C., Gorgels, Tgmf, Wijnhoven, S. W., Diderich, K. E. M., de Wit, J., Mitchell, J. R., van Oostrom, C., Beems, R., Niedernhofer, L. J., Velasco, S., et al. Impaired genome maintenance suppresses the growth hormone-insulin-like growth factor 1 axis in mice with cockayne syndrome PLoS Biology  2007 5:23-38  DOI:10.1371/journal.pbio.0050002  PMID:17326724  PMCID:PMC1698505
    • Niedernhofer, L. J., Garinis, G. A., Raams, A., Lalai, A. S., Robinson, A. R., Appeldoorn, E., Odijk, H., Oostendorp, R., Ahmad, A., Van Leeuwen, W., Theil, A. F., Vermeulen, W., et al. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis Nature  2006 444:1038-1043  DOI:10.1038/nature05456  PMID:17183314
    • Dolle, M. E. T., Busuttil, R. A., Garcia, A. M., Wijnhoven, S., van Drunen, E., Niedernhofer, L. J., van der Horst, G., Hoeijmakers, J. H. J., van Steeg, H., Vijg, J. Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis  2006 596:22-35  DOI:10.1016/j.mrfmmm.2005.11.008  PMID:16472827
    • Niedernhofer, L. J., Lalai, A. S., Hoeijmakers, J. H. J. Fanconi anemia (cross)linked to DNA repair Cell  2005 123:1191-1198  DOI:10.1016/j.cell.2005.12.009  PMID:16377561
    • Prasher, J. M., Lalai, A. S., Heijmans-Antonissen, C., Ploemacher, R. E., Hoeijmakers, J. H., Touw, I. P., Niedernhofer, L. J. Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient ercc1(-/-) mice EMBO Journal  2005 24:861-871  DOI:10.1038/sj.emboj.7600542  PMID:15692571  PMCID:PMC549615
    • Schrader, C. E., Vardo, J., Linehan, E., Twarog, M. Z., Niedernhofer, L. J., Hoejimakers, H. J., Stavnezer, J. Deletion of the nucleotide excision repair gene ercc1 reduces immunoglobulin class switching and alters mutations near switch recombination junctions Journal of Experimental Medicine  2004 200:321-330  DOI:10.1084/jem.20040052  PMID:15280420  PMCID:PMC2211985
    • Niedernhofer, L. J., Odijk, H., Budzowska, M., van Drunen, E., Maas, A., Theil, A. F., de Wit, J., Jaspers, N. G. J., Beverloo, H. B., Hoeijmakers, J. H. J., Kanaar, R. The structure-specific endonuclease ercc1-xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks Molecular and Cellular Biology  2004 24:5776-5787  DOI:10.1128/mcb.24.13.5776-5787.2004  PMID:15199134
    • Zhu, X. D., Niedernhofer, L., Kuster, B., Mann, M., Hoeijmakers, J. H. J., de Lange, T. Ercc1/xpf removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes Molecular Cell  2003 12:1489-1498  DOI:10.1016/s1097-2765(03)00478-7  PMID:14690602
    • Niedernhofer, L. J., Daniels, J. S., Rouzer, C. A., Greene, R. E., Marnett, L. J. Malondialdehyde, a product of lipid peroxidation, is mutagenic in human cells Journal of Biological Chemistry  2003 278:31426-31433  DOI:10.1074/jbc.M212549200  PMID:12775726
    • Mitchell, J. R., Hoeijmakers, J. H. J., Niedernhofer, L. J. Divide and conquer: Nucleotide excision repair battles cancer and ageing Current Opinion in Cell Biology  2003 15:232-240  DOI:10.1016/s0955-0674(03)00018-8  PMID:12648680
    • Niedernhofer, L. J., Essers, J., Weeda, G., Beverloo, B., de Wit, J., Muijtjens, M., Odijk, H., Hoeijmakers, J. H. J., Kanaar, R. The structure-specific endonuclease ercc1-xpf is required for targeted gene replacement in embryonic stem cells EMBO Journal  2001 20:6540-6549  DOI:10.1093/emboj/20.22.6540  PMID:11707424  PMCID:PMC125716
    • Niedernhofer, L. J., Riley, M., SchnetzBoutaud, N., Sanduwaran, G., Chaudhary, A. K., Reddy, G. R., Marnett, L. J. Temperature-dependent formation of a conjugate between tris(hydroxymethyl)aminomethane buffer and the malondialdehyde-DNA adduct pyrimidopurinone Chemical Research in Toxicology  1997 10:556-561  DOI:10.1021/tx960191c  PMID:9168253
    • Basu, A. K., Wood, M. L., Niedernhofer, L. J., Ramos, L. A., Essigmann, J. M. Mutagenic and genotoxic effects of three vinyl chloride-induced DNA lesions: 1,N6-ethenoadenine, 3,N4-ethenocytosine, and 4-amino-5-(imidazol-2-yl)imidazole Biochemistry  1993 32:12793-12801  DOI:10.1021/bi00210a031  PMID:8251500
    • Basu, A. K., Niedernhofer, L. J., Essigmann, J. M. Deoxyhexanucleotide containing a vinyl-chloride induced dna lesion, 1,n6-ethenoadenine - synthesis, physical characterization, and incorporation into a duplex bacteriophage-m13 genome as part of an amber codon Biochemistry  1987 26:5626-5635  DOI:10.1021/bi00392a007  PMID:3314993

featured in

  • Scripps Florida Mentorship Award Honors Laura Niedernhofer and Christoph Rader  Newsletter
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Background

education and training

  • M.D. in Pathology, Vanderbilt University , School of Medicine 1998
  • Ph.D. in Biochemistry, Vanderbilt University , School of Medicine 1996
  • M.S. in Physiology, Georgetown University , School of Medicine 1991
  • B.S. in Chemistry, Duke University 1985
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Contact

full name

  • Laura Niedernhofer

geographic location

  • Scripps Florida 

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