recent publications
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academic article
- Han, Y. C., Zhou, C. M., Shen, H. X., Tan, J., Dong, Q., Zhang, L., McGowan, S. J., Zhao, J., Sowa, G. A., Kang, J. D., Niedernhofer, L. J., Robbins, P. D., et al. Attenuation of ataxia telangiectasia mutated signalling mitigates age-associated intervertebral disc degeneration Aging Cell 2020 DOI:10.1111/acel.13162 PMID:32567210
- Yousefzadeh, M. J., Wilkinson, J. E., Hughes, B., Gadela, N., Ladiges, W. C., Vo, N., Niedernhofer, L. J., Huffman, D. M., Robbins, P. D. Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues Geroscience 2020 42:951-961 DOI:10.1007/s11357-020-00185-1 PMID:32285290 PMCID:PMC7286998
- Zhao, J., Zhang, L., Lu, A. P., Han, Y. C., Colangelo, D., Bukata, C., Scibetta, A., Yousefzadeh, M. J., Li, X. S., Gurkar, A. U., McGowan, S. J., Angelini, L., et al. ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging Aging-US 2020 12:4688-4710 DOI:10.18632/aging.102863 PMID:32201398 PMCID:PMC7138542
- Yousefzadeh, M. J., Zhao, J., Bukata, C., Wade, E. A., McGowan, S. J., Angelini, L. A., Bank, M. P., Gurkar, A. U., McGuckian, C. A., Calubag, M. F., Kato, J. I., Burd, C. E., et al. Tissue specificity of senescent cell accumulation during physiologic and accelerated aging of mice Aging Cell 2020 DOI:10.1111/acel.13094 PMID:31981461
- Flores, R. R., Carbo, L., Kim, E., Van Meter, M., De Padilla, C. M. L., Zhao, J., Colangelo, D., Yousefzadeh, M. J., Angelini, L. A., Zhang, L., Pola, E., Vo, N., et al. Adenoviral gene transfer of a single-chain IL-23 induces psoriatic arthritis-like symptoms in NOD mice FASEB Journal 2019 33:9505-9515 DOI:10.1096/fj.201900420R PMID:31170010 PMCID:PMC6662986
- Fuhrmann-Stroissnigg, H., Santiago, F. E., Grassi, D., Ling, Y., Niedernhofer, L. J., Robbins, P. D. SA-β-galactosidase-based screening assay for the identification of senotherapeutic drugs Journal of Visualized Experiments : JoVE 2019 DOI:10.3791/58133 PMID:31305507
- Bell-Temin, H., Yousefzadeh, M. J., Bondarenko, A., Quarles, E., Jones-Laughner, J., Robbins, P. D., Ladiges, W., Niedernhofer, L. J., Yates, N. A. Measuring biological age in mice using differential mass spectrometry Aging-Us 2019 11:1045-1061 DOI:10.18632/aging.101810 PMID:30745468 PMCID:PMC6382423
- Yousefzadeh, M. J., Zhu, Y., McGowan, S. J., Angelini, L., Fuhrmann-Stroissnigg, H., Xu, M., Ling, Y. Y., Melos, K. I., Pirtskhalava, T., Inman, C. L., McGuckian, C., Wade, E. A., et al. Fisetin is a senotherapeutic that extends health and lifespan EBiomedicine 2018 36:18-28 DOI:10.1016/j.ebiom.2018.09.015 PMID:30279143 PMCID:PMC6197652
- Gurkar, A. U., Robinson, A. R., Cui, Y., Li, X., Allani, S. K., Webster, A., Muravia, M., Fallahi, M., Weissbach, H., Robbins, P. D., Wang, Y., Kelley, E. E., et al. Dysregulation of DAF-16/FOXO3A-mediated stress responses accelerates oxidative DNA damage induced aging Redox Biology 2018 18:191-199 DOI:10.1016/j.redox.2018.06.005 PMID:30031267 PMCID:PMC6076207
- Czerwiriska, J., Nowak, M., Wojtczak, P., Dziuban-Lech, D., Ciesla, J. M., Kolata, D., Gajewska, B., Baranczyk-Kuzma, A., Robinson, A. R., Shane, H. L., Gregg, S. Q., Rigatti, L. H., et al. ERCC1-deficient cells and mice are hypersensitive to lipid peroxidation Free Radical Biology and Medicine 2018 124:79-96 DOI:10.1016/j.freeradbiomed.2018.05.088 PMID:29860127 PMCID:PMC6098728
- Zarakowska, E., Czerwinska, J., Tupalska, A., Yousefzadeh, M. J., Gregg, S. Q., St Croix, C. M., Niedernhofer, L. J., Foksinski, M., Gackowski, D., Szpila, A., Starczak, M., Tudek, B., et al. Oxidation products of 5-methylcytosine are decreased in senescent cells and tissues of progeroid mice Journals of Gerontology Series a-Biological Sciences and Medical Sciences 2018 73:1003-1009 DOI:10.1093/gerona/gly012 PMID:29415265
- Xu, M., Pirtskhalava, T., Farr, J. N., Weigand, B. M., Palmer, A. K., Weivoda, M. M., Inman, C. L., Ogrodnik, M. B., Hachfeld, C. M., Fraser, D. G., Onken, J. L., Johnson, K. O., et al. Senolytics improve physical function and increase lifespan in old age Nature Medicine 2018 24:1246-+ DOI:10.1038/s41591-018-0092-9 PMID:29988130 PMCID:PMC6082705
- Robinson, A. R., Yousefzadeh, M. J., Rozgaja, T. A., Wang, J., Li, X., Tilstra, J. S., Feldman, C. H., Gregg, S. Q., Johnsong, C. H., Skoda, E. M., Frantz, M. C., Bell-Temin, H., et al. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging Redox Biology 2018 17:259-273 DOI:10.1016/j.redox.2018.04.007 PMID:29747066 PMCID:PMC6006678
- Zhao, J., Zhang, L., Mu, X., Doebelin, C., Nguyen, W., Wallace, C., Reay, D. P., McGowan, S. J., Corbo, L., Clemens, P. R., Wilson, G. M., Watkins, S. C., et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation PLoS Biology 2018 16 DOI:10.1371/journal.pbio.2004663 PMID:29889904 PMCID:PMC6013238
- Niedernhofer, L. J., Robbins, P. D. Senotherapeutics for healthy ageing Nature Reviews Drug Discovery 2018 17 PMID:29651106
- Yousefzadeh, M. J., Schafer, M. J., Hooten, N. N., Atkinson, E. J., Evans, M. K., Baker, D. J., Quarles, E. K., Robbins, P. D., Ladiges, W. C., LeBrasseur, N. K., Niedernhofer, L. J. Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans Aging Cell 2018 17 DOI:10.1111/acel.12706 PMID:29290100 PMCID:PMC5847863
- Mori, T., Yousefzadeh, M. J., Faridounnia, M., Chong, J. X., Hisama, F. M., Hudgins, L., Mercado, G., Wade, E. A., Barghouthy, A. S., Lee, L., Martin, G. M., Nickerson, D. A., et al. ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes Human Mutation 2018 39:255-265 DOI:10.1002/humu.23367 PMID:29105242 PMCID:PMC5762268
- Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D. Hsp90 inhibitors as senolytic drugs to extend healthy aging Cell Cycle 2018 17:1048-1055 DOI:10.1080/15384101.2018.1475828 PMID:29886783 PMCID:PMC6110594
- Niedernhofer, L. J., Gurkar, A. U., Wang, Y. S., Vijg, J., Hoeijmakers, J. H. J., Robbins, P. D. Nuclear genomic instability and aging Annual Review of Biochemistry 2018 87:295-322 DOI:10.1146/annurev-biochem-062917-012239 PMID:29925262
- Ngo, K., Pohl, P., Wang, D., Leme, A. S., Lee, J., Di, P., Roughley, P., Robbins, P. D., Niedernhofer, L. J., Sowa, G., Kang, J. D., Shapiro, S. S., et al. ADAMTS5 deficiency protects mice from chronic tobacco smoking-induced intervertebral disc degeneration Spine 2017 42:1521-1528 DOI:10.1097/brs.0000000000002258 PMID:28570296 PMCID:MC5633483
- Kirkland, J. L., Tchkonia, T., Zhu, Y., Niedernhofer, L. J., Robbins, P. D. The clinical potential of senolytic drugs Journal of the American Geriatrics Society 2017 65:2297-2301 DOI:10.1111/jgs.14969 PMID:28869295 PMCID:PMC5641223
- Fuhrmann-Stroissnigg, H., Ling, Y. Y., Zhao, J., McGowan, S. J., Zhu, Y., Brooks, R. W., Grassi, D., Gregg, S. Q., Stripay, J. L., Dorronsoro, A., Corbo, L., Tang, P., et al. Identification of HSP90 inhibitors as a novel class of senolytics Nature Communications 2017 8 DOI:10.1038/s41467-017-00314-z PMID:28871086 PMCID:PMC5583353
- Ngo, K., Patil, P., McGowan, S. J., Niedernhofer, L. J., Robbins, P. D., Kang, J., Sowa, G., Vo, N. Senescent intervertebral disc cells exhibit perturbed matrix homeostasis phenotype Mechanisms of Ageing and Development 2017 166:16-23 DOI:10.1016/j.mad.2017.08.007 PMID:28830687 PMCID:PMC5632945
- Takayama, K., Kawakami, Y., Lavasani, M., Mu, X., Cummins, J. H., Yurube, T., Kuroda, R., Kurosaka, M., Fu, F. H., Robbins, P. D., Niedernhofer, L. J., Huard, J. mTOR signaling plays a critical role in the defects observed in muscle-derived stem/progenitor cells isolated from a murine model of accelerated aging Journal of Orthopaedic Research 2017 35:1375-1382 DOI:10.1002/jor.23409 PMID:27572850
- Robbins, P. D., Niedernhofer, L. J. Advances in therapeutic approaches to extend healthspan: a perspective from the 2nd Scripps Symposium on the Biology of Aging Aging Cell 2017 16:610-614 DOI:10.1111/acel.12620 PMID:28585366 PMCID:PMC5506446
- Flores, R. R., Clauson, C. L., Cho, J., Lee, B. C., McGowan, S. J., Baker, D. J., Niedernhofer, L. J., Robbins, P. D. Expansion of myeloid-derived suppressor cells with aging in the bone marrow of mice through a NF-κB-dependent mechanism Aging Cell 2017 16:480-487 DOI:10.1111/acel.12571 PMID:28229533 PMCID:PMC5418207
- Niedernhofer, L. J., Kirkland, J. L., Ladiges, W. Molecular pathology endpoints useful for aging studies Ageing Research Reviews 2017 35:241-249 DOI:10.1016/j.arr.2016.09.012 PMID:27721062 PMCID:PMC5357461
- Huan, T., Forsberg, E. M., Rinehart, D., Johnson, C. H., Ivanisevic, J., Benton, H. P., Fang, M., Aisporna, A., Hilmers, B., Poole, F. L., Thorgersen, M. P., Adams, M. W. W., et al. Systems biology guided by XCMS Online metabolomics Nature Methods 2017 14:461-462 PMID:28448069
- Zhu, Y., Doornebal, E. J., Pirtskhalava, T., Giorgadze, N., Wentworth, M., Fuhrmann-Stroissnigg, H., Niedernhofer, L. J., Robbins, P. D., Tchkonia, T., Kirkland, J. L. New agents that target senescent cells: the flavone, fisetin, and the BCL-X-L inhibitors, A1331852 and A1155463 Aging 2017 9:955-963 DOI:10.18632/aging.101202 PMID:28273655 PMCID:PMC5391241
- Yu, Y., Cui, Y., Niedernhofer, L. J., Wang, Y. Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage Chemical Research in Toxicology 2016 29:2008-2039 DOI:10.1021/acs.chemrestox.6b00265 PMID:27989142
- Burd, C. E., Gill, M. S., Niedernhofer, L. J., Robbins, P. D., Austad, S. N., Barzilai, N., Kirkland, J. L. Barriers to the preclinical development of therapeutics that target aging mechanisms Journals of Gerontology Series A-Biological Sciences and Medical Sciences 2016 71:1388-1394 DOI:10.1093/gerona/glw112 PMID:27535964 PMCID:PMC5055650
- Montenegro-Burke, J. R., Phommavongsay, T., Aisporna, A. E., Huan, T., Rinehart, D., Forsberg, E., Poole, F. L., Thorgersen, M. P., Adams, M. W., Krantz, G., Fields, M. W., Northen, T. R., et al. Smartphone analytics: mobilizing the lab into the cloud for omicscale analyses Analytical Chemistry 2016 88:9753-9758 DOI:10.1021/acs.analchem.6b02676 PMID:27560777 PMCID:PMC5054939
- Zhu, Y., Tchkonia, T., Fuhrmann-Stroissnigg, H., Dai, H. M. M., Ling, Y. Y. Y., Stout, M. B., Pirtskhalava, T., Giorgadze, N., Johnson, K. O., Giles, C. B., Wren, J. D., Niedernhofer, L. J., et al. Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors Aging Cell 2016 15:428-435 DOI:10.1111/acel.12445 PMID:26711051 PMCID:PMC4854923
- Ladiges, W., Ikeno, Y., Niedernhofer, L., McIndoe, R. A., Ciol, M. A., Ritchey, J., Liggitt, D. The Geropathology Research Network: An interdisciplinary approach for integrating pathology into research on aging Journals of Gerontology Series A-Biological Sciences and Medical Sciences 2016 71:431-434 DOI:10.1093/gerona/glv079 PMID:26243216 PMCID:PMC5014185
- Amato, N. J., Zhai, Q., Navarro, D. C., Niedernhofer, L. J., Wang, Y. In vivo detection and replication studies of α-anomeric lesions of 2'-deoxyribonucleosides Nucleic Acids Research 2015 43:8314-8324 DOI:10.1093/nar/gkv725 PMID:26202973 PMCID:PMC4787794
- Fu, L., Amato, N. J., Wang, P., McGowan, S. J., Niedernhofer, L. J., Wang, Y. Simultaneous quantification of methylated cytidine and adenosine in cellular and tissue RNA by Nano-Flow liquid chromatography-tandem mass spectrometry coupled with the stable isotope-dilution method Analytical Chemistry 2015 87:7653-7659 DOI:10.1021/acs.analchem.5b00951 PMID:26158405 PMCID:PMC4711271
- Gurkar, A. U., Niedernhofer, L. J. Comparison of mice with accelerated aging caused by distinct mechanisms Experimental Gerontology 2015 68:43-50 DOI:10.1016/j.exger.2015.01.045 PMID:25617508 PMCID:PMC4464936
- Zhu, Y., Tchkonia, T., Pirtskhalava, T., Gower, A. C., Ding, H., Giorgadze, N., Palmer, A. K., Ikeno, Y., Hubbard, G. B., Lenburg, M., O'Hara, S. P., LaRusso, N. F., et al. The Achilles' heel of senescent cells: from transcriptome to senolytic drugs Aging Cell 2015 14:644-658 DOI:10.1111/acel.12344 PMID:25754370 PMCID:PMC4531078
- Fu, L., Guerrero, C. R., Zhong, N., Amato, N. J., Liu, Y., Liu, S., Cai, Q., Ji, D., Jin, S. G., Niedernhofer, L. J., Pfeifer, G. P., Xu, G. L., et al. Tet-mediated formation of 5-hydroxymethylcytosine in RNA Journal of the American Chemical Society 2014 136:11582-11585 DOI:10.1021/ja505305z PMID:25073028 PMCID:PMC4140497
- Nasto, L. A., Ngo, K., Leme, A. S., Robinson, A. R., Dong, Q., Roughley, P., Usas, A., Sowa, G. A., Pola, E., Kang, J., Niedernhofer, L. J., Shapiro, S., et al. Investigating the role of DNA damage in tobacco smoking-induced spine degeneration Spine Journal 2014 14:416-423 DOI:10.1016/j.spinee.2013.08.034 PMID:24211096 PMCID:PMC3944725
- Tilstra, J. S., Gaddy, D. F., Zhao, J., Dave, S. H., Niedernhofer, L. J., Plevy, S. E., Robbins, P. D. Pharmacologic IKK/NF-kappa B inhibition causes antigen presenting cells to undergo TNF alpha dependent ROS-mediated programmed cell death Scientific Reports 2014 4:3631 DOI:10.1038/srep03631 PMID:24406986 PMCID:PMC3887388
- Clauson, C., Scharer, O. D., Niedernhofer, L. Advances in understanding the complex mechanisms of DNA interstrand cross-link repair Cold Spring Harbor Perspectives in Biology 2013 5:a012732 DOI:10.1101/cshperspect.a012732 PMID:24086043 PMCID:PMC3783045
- Karakasilioti, I., Kamileri, I., Chatzinikolaou, G., Kosteas, T., Vergadi, E., Robinson, A. R., Tsamardinos, I., Rozgaja, T. A., Siakouli, S., Tsatsanis, C., Niedernhofer, L. J., Garinis, G. A. DNA damage triggers a chronic autoinflammatory response, leading to fat depletion in NER progeria Cell Metabolism 2013 18:403-415 DOI:10.1016/j.cmet.2013.08.011 PMID:24011075 PMCID:PMC4116679
- Vo, N., Niedernhofer, L. J., Nasto, L. A., Jacobs, L., Robbins, P. D., Kang, J., Evans, C. H. An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints Journal of Orthopaedic Research 2013 31:831-837 DOI:10.1002/jor.22204 PMID:23483579 PMCID:PMC3628921
- You, C. J., Dai, X. X., Yuan, B. F., Wang, J., Wang, J. S., Brooks, P. J., Niedernhofer, L. J., Wang, Y. S. A quantitative assay for assessing the effects of DNA lesions on transcription Nature Chemical Biology 2012 8:817-822 DOI:10.1038/nchembio.1046 PMID:22902614 PMCID:PMC3509257
- Nasto, L. A., Seo, H. Y., Robinson, A. R., Tilstra, J. S., Clauson, C. L., Sowa, G. A., Ngo, K., Dong, Q., Pola, E., Lee, J. Y., Niedernhofer, L. J., Kang, J. D., et al. Issls prize winner: Inhibition of nf-kappa b activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging Spine 2012 37:1819-1825 DOI:10.1097/BRS.0b013e31824ee8f7 PMID:22343279 PMCID:PMC3395770
- DeLoia, J. A., Bhagwat, N. R., Darcy, K. M., Strange, M., Tian, C., Nuttall, K., Krivak, T. C., Niedernhofer, L. J. Comparison of ERCC1/XPF genetic variation, mRNA and protein levels in women with advanced stage ovarian cancer treated with intraperitoneal platinum Gynecologic Oncology 2012 126:448-454 DOI:10.1016/j.ygyno.2012.05.006 PMID:22609620 PMCID:PMC3518863
- Matoka, D. J., Yao, V., Harya, D. S., Gregg, J. L., Robinson, A. R., Niedernhofer, L. J., Parwani, A. V., Maier, C., Bacich, D. J. Deficiency of DNA repair nuclease ERCC1-XPF promotes prostate cancer progression in a tissue recombination model Prostate 2012 72:1214-1222 DOI:10.1002/pros.22472 PMID:22212909 PMCID:PMC3490419
- Wang, J., Cao, H. C., You, C. J., Yuan, B. F., Bahde, R., Gupta, S., Nishigori, C., Niedernhofer, L. J., Brooks, P. J., Wang, Y. S. Endogenous formation and repair of oxidatively induced g (8-5m) T intrastrand cross-link lesion Nucleic Acids Research 2012 40:7368-7374 DOI:10.1093/nar/gks357 PMID:22581771 PMCID:PMC3424544
- Wang, D., Nasto, L. A., Roughley, P., Leme, A. S., Houghton, A. M., Usas, A., Sowa, G., Lee, J., Niedernhofer, L., Shapiro, S., Kang, J., Vo, N. Spine degeneration in a murine model of chronic human tobacco smokers Osteoarthritis and Cartilage 2012 20:896-905 DOI:10.1016/j.joca.2012.04.010 PMID:22531458 PMCID:PMC3389285
- Wang, J., Clauson, C. L., Robbins, P. D., Niedernhofer, L. J., Wang, Y. S. The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner Aging Cell 2012 11:714-716 DOI:10.1111/j.1474-9726.2012.00828.x PMID:22530741 PMCID:PMC3399950
- Tilstra, J. S., Robinson, A. R., Wang, J., Gregg, S. Q., Clauson, C. L., Reay, D. P., Nasto, L. A., St Croix, C. M., Usas, A., Vo, N., Huard, J., Clemens, P. R., et al. NF-kB inhibition delays DNA damage-induced senescence and aging in mice Journal of Clinical Investigation 2012 122:2601-2612 DOI:10.1172/jci45785 PMID:22706308 PMCID:PMC3386805
- Su, Y., Orelli, B., Madireddy, A., Niedernhofer, L. J., Scharer, O. D. Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair Journal of Biological Chemistry 2012 287:21846-21855 DOI:10.1074/jbc.M111.337899 PMID:22547097 PMCID:PMC3381147
- Rubatt, J. M., Darcy, K. M., Tian, C. Q., Muggia, F., Dhir, R., Armstrong, D. K., Bookman, M. A., Niedernhofer, L. J., Deloia, J., Birrer, M., Krivak, T. C. Pre-treatment tumor expression of ERCC1 in women with advanced stage epithelial ovarian cancer is not predictive of clinical outcomes: A gynecologic oncology group study Gynecologic Oncology 2012 125:421-426 DOI:10.1016/j.ygyno.2012.01.008 PMID:22261301 PMCID:PMC3490188
- Smith, S. C., Robinson, A. R., Niedernhofer, L. J., Hetman, M. Downregulation of cholesterol biosynthesis genes in the forebrain of ERCC1-deficient mice Neurobiology of Disease 2012 45:1136-1144 DOI:10.1016/j.nbd.2011.12.036 PMID:22245387 PMCID:PMC3345809
- Lu, A. P., Proto, J. D., Guo, L. L., Tang, Y., Lavasani, M., Tilstra, J. S., Niedernhofer, L. J., Wang, B., Guttridge, D. C., Robbins, P. D., Huard, J. NF-kB negatively impacts the myogenic potential of muscle-derived stem cells Molecular Therapy 2012 20:661-668 DOI:10.1038/mt.2011.261 PMID:22158056 PMCID:PMC3293604
- Gregg, S. Q., Gutierrez, V., Robinson, A. R., Woodell, T., Nakao, A., Ross, M. A., Michalopoulos, G. K., Rigatti, L., Rothermel, C. E., Kamileri, I., Garinis, G., Stolz, D. B., et al. A mouse model of accelerated liver aging caused by a defect in DNA repair Hepatology 2012 55:609-621 DOI:10.1002/hep.24713 PMID:21953681 PMCID:PMC3250572
- Lavasani, M., Robinson, A. R., Lu, A. P., Song, M. J., Feduska, J. M., Ahani, B., Tilstra, J. S., Feldman, C. H., Robbins, P. D., Niedernhofer, L. J., Huard, J. Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model Nature Communications 2012 3:608 DOI:10.1038/ncomms1611 PMID:22215083 PMCID:PMC3272577
- Vaezi, A., Wang, X. Z., Buch, S., Gooding, W., Wang, L., Seethala, R. R., Weaver, D. T., D'Andrea, A. D., Argiris, A., Romkes, M., Niedernhofer, L. J., Grandis, J. R. XPF expression correlates with clinical outcome in squamous cell carcinoma of the head and neck Clinical Cancer Research 2011 17:5513-5522 DOI:10.1158/1078-0432.ccr-11-0086 PMID:21737503 PMCID:PMC3156890
- Goss, J. R., Stolz, D. B., Robinson, A. R., Zhang, M. D., Arbujas, N., Robbins, P. D., Glorioso, J. C., Niedernhofer, L. J. Premature aging-related peripheral neuropathy in a mouse model of progeria Mechanisms of Ageing and Development 2011 132:437-442 DOI:10.1016/j.mad,2011.04.010 PMID:21596054 PMCID:PMC3179831
- Gregg, S. Q., Robinson, A. R., Niedernhofer, L. J. Physiological consequences of defects in ercc1-xpf DNA repair endonuclease DNA Repair 2011 10:781-791 DOI:10.1016/j.dnarep.2011.04.026 PMID:21612988 PMCID:PMC3139823
- Wang, D., Vo, N. V., Sowa, G. A., Hartman, R. A., Ngo, K., Choe, S. R., Witt, W. T., Dong, Q., Lee, J. Y., Niedernhofer, L. J., Kang, J. D. Bupivacaine decreases cell viability and matrix protein synthesis in an intervertebral disc organ model system Spine Journal 2011 11:139-146 DOI:10.1016/j.spinee.2010.11.017 PMID:21296298 PMCID:PMC3056334
- Vo, N., Seo, H. Y., Robinson, A., Sowa, G., Bentley, D., Taylor, L., Studer, R., Usas, A., Huard, J., Alber, S., Watkins, S. C., Lee, J., et al. Accelerated aging of intervertebral discs in a mouse model of progeria Journal of Orthopaedic Research 2010 28:1600-1607 DOI:10.1002/jor.21153 PMID:20973062 PMCID:PMC3477798
- Hagelstrom, R. T., Blagoev, K. B., Niedernhofer, L. J., Goodwin, E. H., Bailey, S. M. Hyper telomere recombination accelerates replicative senescence and may promote premature aging Proceedings of the National Academy of Sciences of the United States of America 2010 107:15768-15773 DOI:10.1073/pnas.1006338107 PMID:20798040 PMCID:PMC2936608
- Ahmad, A., Enzlin, J. H., Bhagwat, N. R., Wijgers, N., Raams, A., Appledoorn, E., Theil, A. F., Hoeijmakers, J. H. J., Vermeulen, W., Jaspers, N. G. J., Scharer, O. D., Niedernhofer, L. J. Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients PLoS Genetics 2010 6:e1000871 DOI:10.1371/journal.pgen.1000871 PMID:20221251 PMCID:PMC2832669
- Orelli, B., McClendon, T. B., Tsodikov, O. V., Ellenberger, T., Niedernhofer, L. J., Scharer, O. D. The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways Journal of Biological Chemistry 2010 285:3705-3712 DOI:10.1074/jbc.M109.067538 PMID:19940136 PMCID:PMC2823511
- Bhagwat, N., Olsen, A. L., Wang, A. T., Hanada, K., Stuckert, P., Kanaar, R., D'Andrea, A., Niedernhofer, L. J., McHugh, P. J. XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair Molecular and Cellular Biology 2009 29:6427-6437 DOI:10.1128/mcb.00086-09 PMID:19805513 PMCID:PMC2786876
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