recent publications
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academic article
- Cheung, N., Fung, T. K., Zeisig, B. B., Holmes, K., Rane, J. K., Mowen, K. A., Finn, M. G., Lenhard, B., Chan, L. C., So, C. W. E. Targeting aberrant epigenetic networks mediated by PRMT1 and KDM4C in acute myeloid leukemia Cancer Cell 2016 29:32 DOI:10.1016/j.ccell.2015.12.007 PMID:26766589 PMCID:PMC4712026
- Kolaczkowska, E., Jenne, C. N., Surewaard, B. G. J., Thanabalasuriar, A., Lee, W. Y., Sanz, M. J., Mowen, K., Opdenakker, G., Kubes, P. Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature Nature Communications 2015 6:6673 DOI:10.1038/ncomms7673 PMID:25809117 PMCID:PMC4389265
- Mowen, K. A., David, M. Unconventional post-translational modifications in immunological signaling Nature Immunology 2014 15:512-520 DOI:10.1038/ni.2873 PMID:24840982
- Christophorou, M. A., Castelo-Branco, G., Halley-Stott, R. P., Oliveira, C. S., Loos, R., Radzisheuskaya, A., Mowen, K. A., Bertone, P., Silva, J. C. R., Zernicka-Goetz, M., Nielsen, M. L., Gurdon, J. B., et al. Citrullination regulates pluripotency and histone H1 binding to chromatin Nature 2014 507:104-108 DOI:10.1038/nature12942 PMID:24463520 PMCID:PMC4843970
- MacLeod, A. S., Hemmers, S., Garijo, O., Chabod, M., Mowen, K., Witherden, D. A., Havran, W. L. Dendritic epidermal T cells regulate skin antimicrobial barrier function Journal of Clinical Investigation 2013 123:4364-4374 DOI:10.1172/jci70064 PMID:24051381 PMCID:PMC3784546
- Fernandez-Castaneda, A., Arandjelovic, S., Stiles, T. L., Schlobach, R. K., Mowen, K. A., Gonias, S. L., Gaultier, A. Identification of the low density lipoprotein (ldl) receptor-related protein-1 interactome in central nervous system myelin suggests a role in the clearance of necrotic cell debris Journal of Biological Chemistry 2013 288:4538-4548 DOI:10.1074/jbc.M112.384693 PMID:23264627 PMCID:PMC3576060
- Dillon, M. B., Rust, H. L., Thompson, P. R., Mowen, K. A. Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity Journal of Biological Chemistry 2013 288:27872-27880 DOI:10.1074/jbc.M113.491092 PMID:23946480 PMCID:PMC3784702
- Arandjelovic, S., McKenney, K. R., Leming, S. S., Mowen, K. A. ATP induces protein arginine deiminase 2-dependent citrullination in mast cells through the P2X7 purinergic receptor Journal of Immunology 2012 189:4112-4122 DOI:10.4049/jimmunol.1201098 PMID:22984079 PMCID:PMC3466374
- Dillon, M. B. C., Bachovchin, D. A., Brown, S. J., Finn, M. G., Rosen, H., Cravatt, B. F., Mowen, K. A. Novel inhibitors for PRMT1 discovered by high-throughput screening using activity-based fluorescence polarization ACS Chemical Biology 2012 7:1198-1204 DOI:10.1021/cb300024c PMID:22506763 PMCID:PMC3401332
- Rohrbach, A. S., Slade, D. J., Thompson, P. R., Mowen, K. A. Activation of PAD4 in NET formation Frontiers in Immunology 2012 3:360 DOI:10.3389/fimmu.2012.00360 PMID:23264775 PMCID:PMC3525017
- Rohrbach, A. S., Hemmers, S., Arandjelovic, S., Corr, M., Mowen, K. A. PAD4 is not essential for disease in the K/BxN murine autoantibody-mediated model of arthritis Arthritis Research & Therapy 2012 14:R104 DOI:10.1186/ar3829 PMID:22551352 PMCID:PMC3446481
- Hemmers, S., Teijaro, J. R., Arandjelovic, S., Mowen, K. A. PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection PLoS One 2011 6:e22043 DOI:10.1371/journal.pone.0022043 PMID:21779371 PMCID:PMC3133614
- Weerapana, E., Wang, C., Simon, G. M., Richter, F., Khare, S., Dillon, M. B. D., Bachovchin, D. A., Mowen, K., Baker, D., Cravatt, B. F. Quantitative reactivity profiling predicts functional cysteines in proteomes Nature 2010 468:790-795 DOI:10.1038/nature09472 PMID:21085121 PMCID:PMC3058684
- Arandjelovic, S., Wickramarachchi, D., Hemmers, S., Leming, S. S., Kono, D. H., Mowen, K. A. Mast cell function is not altered by Coronin-1A deficiency Journal of Leukocyte Biology 2010 88:737-745 DOI:10.1189/jlb.0310131 PMID:20643816 PMCID:PMC2974433
- Bonham, K., Hemmers, S., Lim, Y. H., Hill, D. M., Finn, M. G., Mowen, K. A. Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production FEBS Journal 2010 277:2096-2108 DOI:10.1111/j.1742-4658.2010.07623.x PMID:20345902 PMCID:PMC2903848
- Fathman, J. W., Gurish, M. F., Hemmers, S., Bonham, K., Friend, D. S., Grusby, M. J., Glimcher, L. H., Mowen, K. A. NIP45 controls the magnitude of the type 2 T helper cell response Proceedings of the National Academy of Sciences of the United States of America 2010 107:3663-3668 DOI:10.1073/pnas.0914700107 PMID:20133688 PMCID:PMC2840445
- Hemmers, S., Mowen, K. A. T(H)2 bias: Mina tips the balance Nature Immunology 2009 10:806-808 DOI:10.1038/ni0809-806 PMID:19621039
- Mowen, K. A., Glimcher, L. H. Signaling pathways in Th2 development Immunological Reviews 2004 202:203-222 DOI:10.1111/j.0105-2896.2004.00209.x PMID:15546395
- Mowen, K., David, M. Response to Matters Arising Cell 2004 119:589-590 DOI:10.1016/j.cell.2004.11.019
- Mowen, K. A., Schurter, B. T., Fathman, J. W., David, M., Glimcher, L. H. Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes Molecular Cell 2004 15:559-571 DOI:10.1016/j.molcel.2004.06.042 PMID:15327772
- Rengarajan, J., Mowen, K. A., McBride, K. D., Smith, E. D., Singh, H., Glimcher, L. H. Interferon regulatory factor 4 (IRF4) interacts with NFATc2 to modulate interleukin 4 gene expression Journal of Experimental Medicine 2002 195:1003-1012 DOI:10.1084/jem.20011128 PMID:11956291 PMCID:PMC2193700
- Blesofsky, W. A., Mowen, K., Arduini, R. M., Baker, D. P., Murphy, M. A., Bowtell, D. D. L., David, M. Regulation of STAT protein synthesis by c-Cbl Oncogene 2001 20:7326-7333 DOI:10.1038/sj.onc.1204919 PMID:11704862
- Lieberson, R., Mowen, K. A., McBride, K. D., Leautaud, V., Zhang, X. K., Suh, W. K., Wu, L., Glimcher, L. H. Tumor necrosis factor receptor-associated factor (TRAF)2 represses the T helper cell type 2 response through interaction with NFAT-interacting protein (NIP45) Journal of Experimental Medicine 2001 194:89-98 DOI:10.1084/jem.194.1.89 PMID:11435475 PMCID:PMC2193447
- Mowen, K. A., Tang, J., Zhu, W., Schurter, B. T., Shuai, K., Herschman, H. R., David, M. Arginine methylation of STAT1 modulates IFN alpha/beta-induced transcription Cell 2001 104:731-741 DOI:10.1016/s0092-8674(01)00269-0 PMID:11257227
- Mowen, K. A., David, M. Analysis of protein arginine methylation and protein arginine-methyltransferase activity Science's STKE : Signal Transduction Knowledge Environment 2001 2001:pl1 DOI:10.1126/stke.2001.93.pl1 PMID:11752667
- Mowen, K. A., David, M. Cytokine activation of transcription Genetic Engineering 2001 23:35-44 PMID:11570105
- Mowen, K., David, M. Regulation of STAT1 nuclear export by Jak1 Molecular and Cellular Biology 2000 20:7273-7281 DOI:10.1128/mcb.20.19.7273-7281.2000 PMID:10982844 PMCID:PMC86281
- Mowen, K., David, M. Role of the STAT1-SH2 domain and STATE in the activation and nuclear translocation of STAT1 Journal of Biological Chemistry 1998 273:30073-30076 DOI:10.1074/jbc.273.46.30073 PMID:9804758
- Huggenvik, J. I., Michelson, R. J., Collard, M. W., Ziemba, A. J., Gurley, P., Mowen, K. A. Characterization of a nuclear deformed epidermal autoregulatory factor-1 (DEAF-1)-related (NUDR) transcriptional regulator protein Molecular Endocrinology 1998 12:1619-1639 DOI:10.1210/me.12.10.1619 PMID:9773984
- Navarro, L., Mowen, K., Rodems, S., Weaver, B., Reich, N., Spector, D., David, M. Cytomegalovirus activates interferon immediate-early response gene expression and an interferon regulatory factor 3-containing interferon-stimulated response element-binding complex Molecular and Cellular Biology 1998 18:3796-3802 PMID:9632763 PMCID:PMC108963
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