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McKinney, Michele K
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McKinney, Michele K

Graduate Student
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Positions

  • 2008 - 2010 Staff Scientist, Scripps Research
  • 2006 - 2008 Research Associate, Scripps Research

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  • Doctoral Dissertation
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Publications

recent publications
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  • academic article

    • Grevengoed, T. J., Trammell, S. A. J., McKinney, M. K., Petersen, N., Cardone, R. L., Svenningsen, J. S., Ogasawara, D., Nexoe-Larsen, C. C., Knop, F. K., Schwartz, T. W., Kibbey, R. G., Cravatt, B. F., et al. N-acyl taurines are endogenous lipid messengers that improve glucose homeostasis Proceedings of the National Academy of Sciences of the United States of America  2019 116:24770-24778  DOI:10.1073/pnas.1916288116  PMID:31740614  PMCID:PMC6900532
    • Kaczocha, M., Lin, Q. Q., Nelson, L. D., McKinney, M. K., Cravatt, B. F., London, E., Deutsch, D. G. Anandamide externally added to lipid vesicles containing-trapped fatty acid amide hydrolase (FAAH) is readily hydrolyzed in a sterol-modulated fashion ACS Chemical Neuroscience  2012 3:364-368  DOI:10.1021/cn300001w  PMID:22860204  PMCID:PMC3382455
    • Saario, S. M., McKinney, M. K., Speers, A. E., Wang, C., Cravatt, B. F. Clickable, photoreactive inhibitors to probe the active site microenvironment of fatty acid amide hydrolase Chemical Science  2012 3:77-83  DOI:10.1039/c1sc00336d  PMID:22737400  PMCID:PMC3378062
    • Thors, L., Burston, J. J., Alter, B. J., McKinney, M. K., Cravatt, B. F., Ross, R. A., Pertwee, R. G., Gereau, R. W., Wiley, J. L., Fowler, C. J. Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase British Journal of Pharmacology  2010 160:549-560  DOI:10.1111/j.1476-5381.2010.00716.x  PMID:20590565  PMCID:PMC2931556
    • Freigang, S., Zadorozhny, V., McKinney, M. K., Krebs, P., Herro, R., Pawlak, J., Kain, L., Schrantz, N., Masuda, K., Liu, Y., Savage, P. B., Bendelac, A., et al. Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice Journal of Clinical Investigation  2010 120:1873-1884  DOI:10.1172/jci40451  PMID:20484813  PMCID:PMC2877940
    • Ahn, K., Johnson, D. S., Mileni, M., Beidler, D., Long, J. Z., McKinney, M. K., Weerapana, E., Sadagopan, N., Liimatta, M., Smith, S. E., Lazerwith, S., Stiff, C., et al. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain Chemistry & Biology  2009 16:411-420  DOI:10.1016/j.chembiol.2009.02.013  PMID:19389627  PMCID:PMC2692831
    • Ahn, K., McKinney, M. K., Cravatt, B. F. Enzymatic pathways that regulate endocannabinoid signaling in the nervous system Chemical Reviews  2008 108:1687-1707  DOI:10.1021/cr0782067  PMID:18429637  PMCID:PMC3150828
    • degree-related publication Wei, B. Q. Q., Mikkelsen, T. S., McKinney, M. K., Lander, E. S., Cravatt, B. F. A second fatty acid amide hydrolase with variable distribution among placental mammals Journal of Biological Chemistry  2006 281:36569-36578  DOI:10.1074/jbc.M606646200  PMID:17015445
    • degree-related publication Saghatelian, A., McKinney, M. K., Bandell, M., Patapoutian, A., Cravatt, B. F. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels Biochemistry  2006 45:9007-9015  DOI:10.1021/bi0608008  PMID:16866345
    • degree-related publication McKinney, M. K., Cravatt, B. F. Structure-based design of a FAAH variant that discriminates between the N-acyl ethanolamine and taurine families of signaling lipids Biochemistry  2006 45:9016-9022  DOI:10.1021/bi0608010  PMID:16866346
    • degree-related publication McKinney, M. K., Cravatt, B. F. Structure and function of fatty acid amide hydrolase Annual Review of Biochemistry  2005 74:411-432  DOI:10.1146/annurev.biochem.74.082803.133450  PMID:15952893
    • degree-related publication McKinney, M. K., Cravatt, B. F. Evidence for distinct roles in catalysis for residues of the serine-serine-lysine catalytic triad of fatty acid amide hydrolase Journal of Biological Chemistry  2003 278:37393-37399  DOI:10.1074/jbc.M303922200  PMID:12734197
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2001 - 2006
  • B.S. in Biology and Chemistry, Gordon College 1997 - 2000

advisee of

  • graduate advising relationship

    • Cravatt, Benjamin, Ph.D.  candidacy, 2002 - 2006
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Contact

full name

  • Michele K McKinney

geographic location

  • Scripps California 

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