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McKay, Dianne
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McKay, Dianne

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Positions

  • 2018 - Professor of Immunology and Microbiology, Immunology and Microbiology , Scripps Research
  • 2017 - 2018 Associate Professor Adjunct, Immunology and Microbiology , Scripps Research
  • 2012 - 2017 Associate Professor Adjunct, Immunology and Microbial Science (IMS) , Scripps Research
  • 2001 - 2012 Associate Professor, Immunology and Microbial Science (IMS) , Scripps Research
  • 2001 - 2012 Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
Dr. Dianne McKay explores the intracellular signaling events and pathways that lead to the tolerance or rejection of transplanted organs by T cells.

Contact

  • dmckay@scripps.edu

Websites

  • Diane McKay, Ph.D.
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Publications

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    • Danovitch, G. M., Bunnapradist, S., Cohen, D., Hariharan, S., McKay, D., Ratner, L., Stegall, M. D., Steiner, R. W., Stock, P. G., Vincenti, F. Tests for the noninvasive diagnosis of kidney transplant rejection should be evaluated by kidney transplant programs American Journal of Transplantation  2021  DOI:10.1111/ajt.16711  PMID:34080294
    • Kasimsetty, S., Hawkes, A., DeWolf, S. E., Welch, A., McKay, D. B. Blockade of T cell activation induced by the simultaneous absence of Nod1 and Nod2 is bypassed by TLR2 signals Transplant Immunology  2020 65  DOI:10.1016/j.trim.2020.101348  PMID:33706865
    • Kasimsetty, S. G., Hawkes, A., Barekatain, K., Soo, E., Welch, A. K., McKay, D. B. TLR2 and NODs1 and 2 cooperate in inflammatory responses associated with renal ischemia reperfusion injury Transplant Immunology  2020 58  DOI:10.1016/j.trim.2019.101260  PMID:31760144  PMCID:PMC7041897
    • Soo, E., Welch, A., Marsh, C., McKay, D. B. Molecular strategies used by hibernators: Potential therapeutic directions for ischemia reperfusion injury and preservation of human donor organs Transplantation Reviews  2020 34  DOI:10.1016/j.trre.2019.100512  PMID:31648853
    • Soo, E., Marsh, C., Steiner, R., Stocks, L., McKay, D. B. Optimizing organs for transplantation; advancements in perfusion and preservation methods Transplantation Reviews  2020 34  DOI:10.1016/j.trre.2019.100514  PMID:31645271  PMCID:PMC6905200
    • Kasimsetty, S. G., Shigeoka, A. A., Scheinok, A. A., Gavin, A. L., Ulevitch, R. J., McKay, D. B. Lack of both nucleotide-binding oligomerization domain-containing proteins 1 and 2 primes T cells for activation-induced cell death Journal of Immunology  2017 199:1196-1205  DOI:10.4049/jimmunol.1600667  PMID:28652394
    • Rutschmann, S., Crozat, K., Li, X., Du, X., Hanselman, J. C., Shigeoka, A. A., Brandl, K., Popkin, D. L., McKay, D. B., Xia, Y., Moresco, E. M. Y., Beutler, B. Hypopigmentation and maternal-zygotic embryonic lethality caused by a hypomorphic mbtps1 mutation in mice G3-Genes Genomes Genetics  2012 2:499-504  DOI:10.1534/g3.112.002196  PMID:22540041  PMCID:PMC3337478
    • McKay, D. B. The role of innate immunity in donor organ procurement Seminars in Immunopathology  2011 33:169-184  DOI:10.1007/s00281-011-0254-z  PMID:21424913
    • McKay, D. B. Intracellular pattern recognition receptors and renal ischemia Critical Reviews in Immunology  2011 31:297-306  DOI:10.1615/CritRevImmunol.v31.i4.20  PMID:21899512
    • Josephson, M. A., McKay, D. B. Pregnancy and kidney transplantation Seminars in Nephrology  2011 31:100-110  DOI:10.1016/j.semnephrol.2010.10.009  PMID:21266268
    • Shigeoka, A. A., Mueller, J. L., Kambo, A., Mathison, J. C., King, A. J., Hall, W. F., Correia, J. D. S., Ulevitch, R. J., Hoffman, H. M., McKay, D. B. An inflammasome-independent role for epithelial-expressed nlrp3 in renal ischemia-reperfusion injury Journal of Immunology  2010 185:6277-6285  DOI:10.4049/jimmunol.1002330  PMID:20962258  PMCID:PMC3020135
    • McKay, D. B., Josephson, M. Pregnancy in renal transplant recipients Dialysis & Transplantation  2010 39:472-475  DOI:10.1002/dat.20511
    • Josephson, M. A., McKay, D. B. Pregnancy in the renal transplant recipient Obstetrics and Gynecology Clinics of North America  2010 37:211-222  DOI:10.1016/j.ogc.2010.02.008  PMID:20685549
    • Shigeoka, A. A., Kambo, A., Mathison, J. C., King, A. J., Hall, W. F., da Silva Correia, J., Ulevitch, R. J., McKay, D. B. Nod1 and nod2 are expressed in human and murine renal tubular epithelial cells and participate in renal ischemia reperfusion injury Journal of Immunology  2010 184:2297-2304  DOI:10.4049/jimmunol.0903065  PMID:20124104  PMCID:PMC3020136
    • Engebretsen, L., Steffen, K., Bahr, R., Broderick, C., Dvorak, J., Janarv, P. M., Johnson, A., Leglise, M., Mamisch, T. C., McKay, D., Micheli, L., Schamasch, P., et al. The international olympic committee consensus statement on age determination in high-level young athletes British Journal of Sports Medicine  2010 44:476-484  DOI:10.1136/bjsm.2010.073122  PMID:20519254
    • Fine, R. N., Becker, Y., De Geest, S., Eisen, H., Ettenger, R., Evans, R., Rudow, D. L., McKay, D., Neu, A., Nevins, T., Reyes, J., Wray, J., et al. Nonadherence consensus conference summary report American Journal of Transplantation  2009 9:35-41  DOI:10.1111/j.1600-6143.2008.02495.x  PMID:19133930
    • Mills, R. E., Taylor, K. R., Podshivalova, K., McKay, D. B., Jameson, J. M. Defects in skin γδ T cell function contribute to delayed wound repair in rapamycin-treated mice Journal of Immunology  2008 181:3974-3983  PMID:18768852  PMCID:PMC2547144
    • McKay, D., Potter, S. R., Behrend, T., Stella, F., Steinberg, S. Patients seeking alternatives to the long waiting list: A reality faced by transplant physicians Progress in Transplantation  2008 18:203-207  PMID:18831487
    • McKay, D. B., Josephson, M. A. Pregnancy after kidney transplantation Clinical Journal of the American Society of Nephrology  2008 3:S117-S125  DOI:10.2215/cjn.02980707  PMID:18308999  PMCID:PMC3152271
    • Shigeoka, A. A., Holscher, T. D., King, A. J., Hallt, F. W., Kiosses, W. B., Tobias, P. S., Mackman, N., McKay, D. B. Tlr2 is constitutively expressed within the kidney and participates in ischemic renal injury through both myd88-dependent and -independent pathways Journal of Immunology  2007 178:6252-6258  PMID:17475853
    • Josephson, M. A., McKay, D. B. Considerations in the medical management of pregnancy in transplant recipients Advances in Chronic Kidney Disease  2007 14:156-167  DOI:10.1053/j.ackd.2007.01.006  PMID:17395118
    • Zambricki, E., Zal, T., Yachi, P., Shigeoka, A., Sprent, J., Gascoigne, N., McKay, D. In vivo anergized T cells form altered immunological synapses in vitro American Journal of Transplantation  2006 6:2572-2579  DOI:10.1111/j.1600-6143.2006.01517.x  PMID:16952297
    • McKay, D., Shigeoka, A., Rubinstein, M., Surh, C., Sprent, J. Simultaneous deletion of myd88 and trif delays major histocompatibility and minor antigen mismatch allograft rejection European Journal of Immunology  2006 36:1994-2002  DOI:10.1002/eji.200636249  PMID:16874736
    • McKay, D. B., Josephson, M. A. Medical progress - pregnancy in recipients of solid organs - effects on mother and child New England Journal of Medicine  2006 354:1281-1293  DOI:10.1056/NEJMra050431  PMID:16554530
    • Zambricki, E., Shigeoka, A., Kishimoto, H., Sprent, J., Burakoff, S., Carpenter, C., Milford, E., McKay, D. Signaling t-cell survival and death by il-2 and il-15 American Journal of Transplantation  2005 5:2623-2631  DOI:10.1111/j.1600-6143.2005.01075.x  PMID:16212621
    • Rubel, J. R., Milford, E. L., McKay, D. B., Jarcho, J. A. Renal insufficiency and end-stage renal disease in the heart transplant population Journal of Heart and Lung Transplantation  2004 23:289-300  DOI:10.1016/s1053-2498(03)00191-8  PMID:15019638
    • Kwon, A. R., Kessler, B. M., Overkleeft, H. S., McKay, D. B. Structure and reactivity of an asymmetric complex between hslv and i-domain deleted hslu, a prokaryotic homolog of the eukaryotic proteasome Journal of Molecular Biology  2003 330:185-195  DOI:10.1016/s0022-2836(03)00580-1  PMID:12823960
    • Sousa, M. C., Kessler, B. M., Overkleeft, H. S., McKay, D. B. Crystal structure of hsiuv complexed with a vinyl sulfone inhibitor: Corroboration of a proposed mechanism of allosteric activation of hsiv by hsiu Journal of Molecular Biology  2002 318:779-785  DOI:10.1016/s0022-2836(02)00145-6  PMID:12054822
    • Halamay, K. E., Kirkman, R. L., Sun, L. H., Yamada, A., Fragoso, R. C., Shimizu, K., Mitchell, R. N., McKay, D. B. Cd8 t cells are sufficient to mediate allorecognition and allograft rejection Cellular Immunology  2002 216:6-14  DOI:10.1016/s0008-8749(02)00530-0  PMID:12381345
    • Tkaczuk, J., Yu, C. L., Baksh, S., Milford, E. L., Carpenter, C. B., Burakoff, S. J., McKay, D. B. Effect of anti-il-2r alpha antibody on il-2-induced jak/stat signaling American Journal of Transplantation  2002 2:31-40  DOI:10.1034/j.1600-6143.2002.020107.x  PMID:12095053
    • Wedekind, J. E., Trame, C. B., Dorywalska, M., Koehl, P., Raschke, T. M., McKee, M., FitzGerald, D., Collier, R. J., McKay, D. B. Refined crystallographic structure of pseudomonas aeruginosa exotoxin a and its implications for the molecular mechanism of toxicity Journal of Molecular Biology  2001 314:823-837  DOI:10.1006/jmbi.2001.5195  PMID:11734000
    • Tkaczuk, J., Milford, E., Yu, C., Baksh, S., Carpenter, C., Burakoff, S., McKay, D. Intracellular signaling consequences of anti-il-2r alpha blockade by daclizumab Transplantation Proceedings  2001 33:212-213  DOI:10.1016/s0041-1345(00)01978-3  PMID:11266783
    • Sousa, M. C., Trame, C. B., Tsuruta, H., Wilbanks, S. M., Reddy, V. S., McKay, D. B. Crystal and solution structures of an HslUV protease-chaperone complex Cell  2000 103:633-643  DOI:10.1016/s0092-8674(00)00166-5  PMID:11106733
    • Tran, H. T. B., Acharya, M. K., McKay, D. B., Sayegh, M. H., Carpenter, C. B., Auchincloss, H., Kirkman, R. L., Milford, E. L. Avoidance of cyclosporine in renal transplantation: Effects of daclizumab, mycophenolate mofetil, and steroids Journal of the American Society of Nephrology  2000 11:1903-1909  PMID:11004222
    • McKay, D. B., Irie, H. Y., Hollander, G., Ferrara, Jlmf, Strom, T. B., Li, Y. S., Burakoff, S. J. Antigen-induced unresponsiveness results in altered t cell signaling Journal of Immunology  1999 163:6455-6461  PMID:10586036
    • McKay, D. B., Milford, E. L., Carpenter, C. B., Kartashov, A. I., Schoen, F. J., Loh, E., Aranki, S. F., Couper, G. S., Mudge, G. H. T-cell activation in cardiac transplant recipients Transplantation  1994 58:241-245  PMID:8042242
    • McKay, D. B., Vazquez, M. A., Redline, R. W., Lu, C. Y. Macrophage functions are regulated by murine decidual and tumor extracellular matrices Journal of Clinical Investigation  1992 89:134-142  DOI:10.1172/jci115553  PMID:1729266
    • Kirkman, R. L., Shapiro, M. E., Carpenter, C. B., McKay, D. B., Milford, E. L., Ramos, E. L., Tilney, N. L., Waldmann, T. A., Zimmerman, C. E., Strom, T. B. A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation Transplantation Proceedings  1991 23:1066-1067  PMID:1989150
    • Kirkman, R. L., Shapiro, M. E., Carpenter, C. B., McKay, D. B., Milford, E. L., Ramos, E. L., Tilney, N. L., Waldmann, T. A., Zimmerman, C. E., Strom, T. B. A randomized prospective trial of anti-Tac monoclonal antibody in human renal transplantation Transplantation  1991 51:107-113  DOI:10.1097/00007890-199101000-00016  PMID:1846250
    • Redline, R. W., McKay, D. B., Vazquez, M. A., Papaioannou, V. E., Lu, C. Y., Shea, C. M., Schmalzried, S. R. Macrophage functions are regulated by the substratum of murine decidual stromal cells Journal of Clinical Investigation  1990 85:1951-1958  DOI:10.1172/jci114658  PMID:2347918
    • Lu, C. Y., Redline, R. W., Shea, C. M., Dustin, L. B., McKay, D. B. Pregnancy as a natural model of allograft tolerance - interactions between adherent macrophages and trophoblast populations Transplantation  1989 48:848-855  DOI:10.1097/00007890-198911000-00025  PMID:2573182
    • Ertel, A. N., Millender, L. H., Nalebuff, E., McKay, D., Leslie, B. Flexor tendon ruptures in patients with rheumatoid-arthritis Journal of Hand Surgery-American Volume  1988 13A:860-866  DOI:10.1016/0363-5023(88)90260-2
    • Allured, V. S., Collier, R. J., Carroll, S. F., McKay, D. B. Structure of exotoxin a of pseudomonas aeruginosa at 3.0 Å resolution Proceedings of the National Academy of Sciences of the United States of America  1986 83:1320-1324  DOI:10.1073/pnas.83.5.1320  PMID:3006045  PMCID:PMC323067
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Research

research overview

  • There are two areas of interest of our laboratory. The first is on defining how intracellular signaling proteins are modified in acquired peripheral T cell tolerance to alloantigens. We have identified several proximal T cell receptor-coupled signaling molecules that are altered in tolerant peripheral T cells and are now focused on understanding the events that lead to alteration of these critical signaling proteins and to the initial events associated with activation of host T cells by donor antigen presenting cells.

    The second interest of our laboratory is on defining the signaling pathways that mediate the expansion of activated T cells in response to transplantation antigens. The long-range goal is to develop effective ways to block proliferative signals and prevent allograft rejection. Transplantation of allogeneic tissues induces vigorous expansion of host T cells with specificity to donor alloantigens. The processes of activation and cell division are differentially regulated by intracellular signals evoked through cell surface receptor ligation. A classic example is seen by IL-2/IL-2R ligation, which culminates in three distinct intracellular signaling pathways including two that are important for T cell proliferation - the Jak/STAT pathway and the RAS/MAPK pathway. A third pathway the PI3K/Atk pathway provides an important apoptotic pathway that explains the dual role of IL-2 - to induce proliferation and apoptosis. We are evaluating the intracellular signaling mechanisms that lead to effective blockade of growth factor receptor ligation. In the microenvironment of an allogeneic organ, there may be several growth factors which influence the expansion of potentially alloreactive T cells and understanding these factors may lead to better use of therapeutic growth factor blockade.
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Background

education and training

  • M.D. in Medicine, The University of Chicago , Pritzker School of Medicine 1983
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Contact

full name

  • Dianne McKay

geographic location

  • Scripps California 

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