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Maximov, Anton
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Maximov, Anton

Faculty Member
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Positions

  • 2017 - Associate Professor (tenured), Neuroscience , Scripps Research
  • 2016 - Associate Professor (tenured) (Joint Appointment), Dorris Neuroscience Center , Scripps Research
  • 2007 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2016 - 2017 Associate Professor (tenured), Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2014 - 2016 Associate Professor, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2014 - 2016 Associate Professor (Joint Appointment), Dorris Neuroscience Center , Scripps Research
  • 2013 - 2014 Assistant Professor, Molecular and Cellular Neuroscience (MCN) , Scripps Research
  • 2007 - 2014 Assistant Professor (Joint Appointment), Dorris Neuroscience Center , Scripps Research
  • 2007 - 2012 Assistant Professor, Cell Biology , Scripps Research
Dr. Anton Maximov combines genetic, biochemical, optical, and electrophysiological methods
to study synapse development and function in the central nervous system.

Contact

  • amaximov@scripps.edu

Websites

  • Anton Maximov, Ph.D.
  • Laboratory Website
  • Publications
  • Research
  • Teaching
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Publications

recent publications
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  • Publications without PubMed PMIDs

  • academic article

    • Zhu, Y., Huang, M., Bushong, E., Phan, S., Uytiepo, M., Beutter, E., Boemer, D., Tsui, K., Ellisman, M., Maximov, A. Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription Nature Communications  2019 10  DOI:10.1038/s41467-019-11409-0  PMID:31375688  PMCID:PMC6677776
    • Shimojo, M., Madara, J., Pankow, S., Liu, X., Yates III, J., Sudhof, T. C., Maximov, A. Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticity Genes & Development  2019 33:365-376  DOI:10.1101/gad.320077.118  PMID:30808661  PMCID:PMC6411015
    • Sando, R., Bushong, E., Zhu, Y., Huang, M., Considine, C., Phan, S., Ju, S., Uytiepo, M., Ellisman, M., Maximov, A. Assembly of excitatory synapses in the absence of glutamatergic neurotransmission Neuron  2017 94:312-321  DOI:10.1016/j.neuron.2017.03.047  PMID:28426966
    • Lobanova, A., She, R., Pieraut, S., Clapp, C., Maximov, A., Denchi, E. L. Different requirements of functional telomeres in neural stem cells and terminally differentiated neurons Genes & Development  2017 31:639-647  DOI:10.1101/gad.295402.116  PMID:28428263  PMCID:PMC5411705
    • Kwon, S. K., Sando III, R., Lewis, T. L., Hirabayashi, Y., Maximov, A., Polleux, F. LKB1 regulates mitochondria-dependent presynaptic calcium clearance and neurotransmitter release properties at excitatory synapses along cortical axons PLoS Biology  2016 14  DOI:10.1371/journal.pbio.1002516  PMID:27429220  PMCID:PMC4948842
    • Shimojo, M., Courchet, J., Pieraut, S., Torabi-Rander, N., Sando III, R., Polleux, F., Maximov, A. SNAREs controlling vesicular release of BDNF and development of callosal axons Cell Reports  2015 11:1054-1066  DOI:10.1016/j.celrep.2015.04.032  PMID:25959820  PMCID:PMC4439258
    • Soragni, E., Miao, W., Iudicello, M., Jacoby, D., De Mercanti, S., Clerico, M., Longo, F., Piga, A., Ku, S., Campau, E., Du, J., Penalver, P., et al. Epigenetic therapy for Friedreich ataxia Annals of Neurology  2014 76:489-508  DOI:10.1002/ana.24260  PMID:25159818  PMCID:PMC4361037
    • Pieraut, S., Gounko, N., Sando, R., Dang, W., Rebboah, E., Panda, S., Madisen, L., Zeng, H., Maximov, A. Experience-dependent remodeling of basket cell networks in the dentate gyrus Neuron  2014 84:107-122  DOI:10.1016/j.neuron.2014.09.012  PMID:25277456  PMCID:PMC4197970
    • Sando, R., Baumgaertel, K., Pieraut, S., Torabi-Rander, N., Wandless, T. J., Mayford, M., Maximov, A. Inducible control of gene expression with destabilized Cre Nature Methods  2013 10:1085-1088  DOI:10.1038/nmeth.2640  PMID:24056874  PMCID:PMC3947879
    • Mairet-Coello, G., Courchet, J., Pieraut, S., Courchet, V., Maximov, A., Polleux, F. The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation Neuron  2013 78:94-108  DOI:10.1016/j.neuron.2013.02.003  PMID:23583109  PMCID:PMC3784324
    • Sando, R., Gounko, N., Pieraut, S., Liao, L. J., Yates, J., Maximov, A. HDAC4 governs a transcriptional program essential for synaptic plasticity and memory Cell  2012 151:821-834  DOI:10.1016/j.cell.2012.09.037  PMID:23141539  PMCID:PMC3496186
    • Liao, L. J., Sando, R. C., Farnum, J. B., Vanderklish, P. W., Maximov, A., Yates, J. R. 15N-labeled brain enables quantification of proteome and phosphoproteome in cultured primary neurons Journal of Proteome Research  2012 11:1341-1353  DOI:10.1021/pr200987h  PMID:22070516  PMCID:PMC3279198
    • Cao, P., Maximov, A., Sudhof, T. C. Activity-dependent igf-1 exocytosis is controlled by the ca(2+)-sensor synaptotagmin-10 Cell  2011 145:300-311  DOI:10.1016/j.cell.2011.03.034  PMID:21496647  PMCID:PMC3102833
    • Segovia, M., Ales, E., Montes, M. A., Bonifas, I., Jemal, I., Lindau, M., Maximov, A., Sudhof, T. C., de Toledo, G. A. Push-and-pull regulation of the fusion pore by synaptotagmin-7 Proceedings of the National Academy of Sciences of the United States of America  2010 107:19032-19037  DOI:10.1073/pnas.1014070107  PMID:20956309  PMCID:PMC2973888
    • Maximov, A., Tang, J., Yang, X., Pang, Z. P. P., Sudhof, T. C. Complexin controls the force transfer from SNARE complexes to membranes in fusion Science  2009 323:516-521  DOI:10.1126/science.1166505  PMID:19164751  PMCID:PMC3235366
    • Maximov, A., Lao, Y., Li, H., Chen, X. C., Rizo, J., Sorensen, J. B., Sudhof, T. C. Genetic analysis of synaptotagmin-7 function in synaptic vesicle exocytosis Proceedings of the National Academy of Sciences of the United States of America  2008 105:3986-3991  DOI:10.1073/pnas.0712372105  PMID:18308933  PMCID:PMC2268828
    • Gustavsson, N., Lao, Y., Maximov, A., Chuang, J. C., Kostromina, E., Repa, J. J., Li, C., Radda, G. K., Sudhof, T. C., Han, W. P. Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice Proceedings of the National Academy of Sciences of the United States of America  2008 105:3992-3997  DOI:10.1073/pnas.0711700105  PMID:18308938  PMCID:PMC2268794
    • Schonn, J. S., Maximov, A., Lao, Y., Sudhof, T. C., Sorensen, J. B. Synaptotagmin-1 and-7 are functionally overlapping ca2+ sensors for exocytosis in adrenal chromaffin cells Proceedings of the National Academy of Sciences of the United States of America  2008 105:3998-4003  DOI:10.1073/pnas.0712373105  PMID:18308932  PMCID:PMC2268838
    • Maximov, A., Pang, Z. P. P., Tervo, D. G. R., Sudhof, T. C. Monitoring synaptic transmission in primary neuronal cultures using local extracellular stimulation Journal of Neuroscience Methods  2007 161:75-87  DOI:10.1016/j.jneumeth.2006.10.009  PMID:17118459
    • Maximov, A., Shin, O. H., Liu, X. R., Sudhof, T. C. Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release Journal of Cell Biology  2007 176:113-124  DOI:10.1083/jcb.200607021  PMID:17190793  PMCID:PMC2063632
    • Tang, J., Maximov, A., Shin, O. H., Dai, H., Rizo, J., Sudhof, T. C. A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis Cell  2006 126:1175-1187  DOI:10.1016/j.cell.2006.08.030  PMID:16990140
    • Pang, Z. P., Sun, J. Y., Rizo, J., Maximov, A., Sudhof, T. C. Genetic analysis of synaptotagmin 2 in spontaneous and ca2+-triggered neurotransmitter release EMBO Journal  2006 25:2039-2050  DOI:10.1038/sj.emboj.7601103  PMID:16642042  PMCID:PMC1462977
    • Maximov, A., Sudhof, T. C. Autonomous function of synaptotagmin 1 in triggering synchronous release independent of asynchronous release Neuron  2005 48:547-554  DOI:10.1016/j.neuron.2005.09.006  PMID:16301172
    • Han, W. P., Rhee, J. S., Maximov, A., Lin, W. C., Hammer, R. E., Rosenmund, C., Sudhof, T. C. C-terminal ecfp fusion impairs synaptotagmin 1 function - crowding out synaptotagmin 1 Journal of Biological Chemistry  2005 280:5089-5100  DOI:10.1074/jbc.M408757200  PMID:15561725
    • Zhang, H., Maximov, A., Fu, Y., Xu, F., Tang, T. S., Tkatch, T., Surmeier, D. J., Bezprozvanny, I. Association of ca(v)1.3 l-type calcium channels with shank Journal of Neuroscience  2005 25:1037-1049  DOI:10.1523/jneurosci.4554-04.2005  PMID:15689539
    • Shin, O. H., Maximov, A., Lim, B. K., Rizo, J., Sudhof, T. C. Unexpected ca2+-binding properties of synaptotagmin 9 Proceedings of the National Academy of Sciences of the United States of America  2004 101:2554-2559  DOI:10.1073/pnas.0308477100  PMID:14983047  PMCID:PMC356988
    • Han, W. P., Rhee, J. S., Maximov, A., Lao, Y., Mashimo, T., Rosenmund, C., Sudhof, T. C. N-glycosylation is essential for vesicular targeting of synaptotagmin 1 Neuron  2004 41:85-99  DOI:10.1016/s0896-6273(03)00820-1  PMID:14715137
    • Tang, T. S., Tu, H. P., Chan, E. Y. W., Maximov, A., Wang, Z. N., Wellington, C. L., Hayden, M. R., Bezprozvanny, I. Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1 Neuron  2003 39:227-239  DOI:10.1016/s0896-6273(03)00366-0  PMID:12873381
    • Maximov, A., Tang, T. S., Bezprozvanny, I. Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1n protein in neurons Molecular and Cellular Neuroscience  2003 22:271-283  DOI:10.1016/s1044-7431(02)00027-1  PMID:12676536
    • Maximov, A., Bezprozvanny, I. Synaptic targeting of n-type calcium channels in hippocampal neurons Journal of Neuroscience  2002 22:6939-6952  PMID:12177192  PMCID:PMC3307533
    • Bezprozvanny, I., Maximov, A. PDZ domains: evolving classification FEBS Letters  2002 512:347-349  DOI:10.1016/s0014-5793(02)02221-4
    • Bezprozvanny, I., Maximov, A. Classification of PDZ domains FEBS Letters  2001 509:457-462  DOI:10.1016/s0014-5793(01)03214-8  PMID:11749973
    • Bezprozvanny, I., Maximov, A. PDZ domains: More than just a glue Proceedings of the National Academy of Sciences of the United States of America  2001 98:787-789  DOI:10.1073/pnas.98.3.787  PMID:11158544  PMCID:PMC33366
    • Gao, B. N., Sekido, Y., Maximov, A., Saad, M., Forgacs, E., Latif, F., Wei, M. H., Lerman, M., Lee, J. H., Perez-Reyes, E., Bezprozvanny, I., Minna, J. D. Functional properties of a new voltage-dependent calcium channel alpha(2)delta auxiliary subunit gene (cacna2d2) Journal of Biological Chemistry  2000 275:12237-12242  DOI:10.1074/jbc.275.16.12237  PMID:10766861
    • Maximov, A., Sudhof, T. C., Bezprozvanny, I. Association of neuronal calcium channels with modular adaptor proteins Journal of Biological Chemistry  1999 274:24453-24456  DOI:10.1074/jbc.274.35.24453  PMID:10455105
    • Maximov, A. V., Vedernikova, E. A., Hinssen, H., Khaitlina, S. Y., Negulyaev, Y. A. Ca-dependent regulation of na+-selective channels via actin cytoskeleton modification in leukemia cells FEBS Letters  1997 412:94-96  DOI:10.1016/s0014-5793(97)00754-0  PMID:9257697
    • Negulyaev, Y. A., Maximov, A. V., Vedernikova, E. A., Katina, I. E. Voltage-insensitive na channels of different selectivity in human leukemic cells General Physiology and Biophysics  1997 16:163-173  PMID:9437257
    • Negulyaev, Y. A., Vedernikova, E. A., Maximov, A. V. Disruption of actin filaments increases the activity of sodium-conducting channels in human myeloid leukemia cells Molecular Biology of the Cell  1996 7:1857-1864  PMID:8970150  PMCID:PMC276035

featured in

  • Kristin Baldwin and Anton Maximov Receive Baxter Foundation Young Faculty Awards  Newsletter
  • Scripps Research Institute Dedicates Dorris Neuroscience Center  News Release
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Research

research overview

  • Synapse Development and Function in Mammalian Central Nervous System

    Individual neurons connect into functional circuits via synapses, asymmetrical cellular junctions that transmit signals with remarkable speed and precision. The ability of neurons to change the efficacy of synaptic transmission in response to external sensory stimuli is critical for our abilities to learn, remember, and produce behavioral responses. We are interested in understanding how synapses form and operate in normal mammalian brain, and how deficits in synaptic transmission and plasticity translate into cognitive abnormalities. The current research in our laboratory is focused on dissecting the membrane trafficking pathways controlling fast release of chemical neurotransmitters and secretion of soluble factors that modulate synaptic function. Our goals are to define the molecular architecture of synaptic secretory organelles, to elucidate the mechanisms regulating their intracellular trafficking and exocytosis, and to determine how experience-dependent changes in synaptic secretion impact the neural circuits in cortex and hippocampus. A second major direction in the lab is to elucidate the mechanisms governing synaptic integration. The ultimate challenge of regenerative medicine is to develop new treatments for replacement of human neurons that were lost or permanently damaged due to physical injury or illness. The promise of induced pluripotent stem (iPS) cells is based on their capacity to form different cell types, which potentially enables autologous implantation treatments. However it is still unclear which neuron subtypes can be derived from iPS cells, which genes define neuronal identity during stem cell differentiation, and whether these neurons are capable of forming fully functional synapses and integrating into existing circuits. To address these questions, our laboratory is using a multidisciplinary approach that combines genetic, biochemical, optical, and electrophysiological methods.

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Teaching

advisees

  • graduate advising relationship

    • Huang, Min, Ph.D.  candidate, 2015 -
    • Simpson, Sierra, Ph.D.  candidate, 2015 -
    • Xie, Yi, Ph.D.  candidate, 2019 -
    • Sando, Richard, Ph.D.  candidate, 2010 - 2014
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Background

education and training

  • Ph.D. in Cytology, Russian Academy of Sciences 2007
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Contact

full name

  • Anton Vladimir Maximov

geographic location

  • Scripps California 

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