recent publications
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academic article
- Mauro, V. P. Codon optimization in the production of recombinant biotherapeutics: potential risks and considerations BioDrugs 2018 32:69-81 DOI:10.1007/s40259-018-0261-x PMID:29392566
- Sullivan, C. J., Pendleton, E. D., Sasmor, H. H., Hicks, W. L., Farnum, J. B., Muto, M., Amendt, E. M., Schoborg, J. A., Martin, R. W., Clark, L. G., Anderson, M. J., Choudhury, A., et al. A cell-free expression and purification process for rapid production of protein biologics Biotechnology Journal 2016 11:238-248 DOI:10.1002/biot.201500214 PMID:26427345
- Mauro, V. P., Matsuda, D. Translation regulation by ribosomes: Increased complexity and expanded scope RNA Biology 2016 13:748-755 DOI:10.1080/15476286.2015.1107701 PMID:26513496 PMCID:PMC5013984
- Mauro, V. P., Chappell, S. A. A critical analysis of codon optimization in human therapeutics Trends in Molecular Medicine 2014 20:604-613 DOI:10.1016/j.molmed.2014.09.003 PMID:25263172 PMCID:PMC4253638
- Matsuda, D., Mauro, V. P. Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo Proceedings of the National Academy of Sciences of the United States of America 2014 111:15385-15389 DOI:10.1073/pnas.1413472111 PMID:25313046 PMCID:PMC4217472
- Burman, L. G., Mauro, V. P. Analysis of rrna processing and translation in mammalian cells using a synthetic 18s rrna expression system Nucleic Acids Research 2012 40:8085-8098 DOI:10.1093/nar/gks530 PMID:22718970 PMCID:PMC3439915
- Matsuda, D., Mauro, V. P. Determinants of initiation codon selection during translation in mammalian cells PLoS One 2010 5:e15057 DOI:10.1371/journal.pone.0015057 PMID:21124832 PMCID:PMC2991327
- Tahiri-Alaoui, A., Matsuda, D., Xu, H. T., Panagiotis, P., Burman, L., Lambeth, L. S., Petherbridge, L., James, W., Mauro, V., Nair, V. The 5' leader of the mRNA encoding the Marek's disease virus serotype 1 pp14 protein contains an intronic internal ribosome entry site with allosteric properties Journal of Virology 2009 83:12769-12778 DOI:10.1128/jvi.01010-09 PMID:19793814 PMCID:PMC2786844
- Koh, D. C., Mauro, V. P. Reconciling contradictory reports regarding translation of BACE1 mRNA: initiation mechanism is altered by different expression systems RNA Biology 2009 6:54-58 DOI:10.4161/rna.6.1.7567 PMID:19106624
- Panopoulos, P., Mauro, V. P. Antisense masking reveals contributions of mrna- rrna base pairing to translation of gtx and fgf2 mrnas Journal of Biological Chemistry 2008 283:33087-33093 DOI:10.1074/jbc.M804904200 PMID:18832380 PMCID:PMC2586266
- Mauro, V. P., Edelman, G. M. The ribosome filter redux Cell Cycle 2007 6:2246-2251 DOI:10.4161/cc.6.18.4739 PMID:17890902 PMCID:PMC2930609
- Chappell, S. A., Edelman, G. M., Mauro, V. P. Ribosomal tethering and clustering as mechanisms for translation initiation Proceedings of the National Academy of Sciences of the United States of America 2006 103:18077-18082 DOI:10.1073/pnas.0608212103 PMID:17110442 PMCID:PMC1838709
- Chappell, S. A., Dresios, J., Edelman, G. M., Mauro, V. P. Ribosomal shunting mediated by a translational enhancer element that base pairs to 18s rrna Proceedings of the National Academy of Sciences of the United States of America 2006 103:9488-9493 DOI:10.1073/pnas.0603597103 PMID:16769881 PMCID:PMC1480434
- Dresios, J., Chappell, S. A., Zhou, W., Mauro, V. P. An mrna-rrna base-pairing mechanism for translation initiation in eukaryotes Nature Structural & Molecular Biology 2006 13:30-34 DOI:10.1038/nsmb1031 PMID:16341227
- Zhou, W., Edelman, G. M., Mauro, V. P. A positive feedback vector for identification of nucleotide sequences that enhance translation Proceedings of the National Academy of Sciences of the United States of America 2005 102:6273-6278 DOI:10.1073/pnas.0409892102 PMID:15845766 PMCID:PMC1088366
- Wang, Y. L., Iyer, M., Annala, A. J., Chappell, S., Mauro, V., Gambhir, S. S. Noninvasive monitoring of target gene expression by imaging reporter gene expression in living animals using improved bicistronic vectors Journal of Nuclear Medicine 2005 46:667-674 PMID:15809490
- Dresios, J., Aschrafi, A., Owens, G. C., Vanderklish, P. W., Edelman, G. M., Mauro, V. P. Cold stress-induced protein rbm3 binds 60s ribosomal subunits, alters rnicrorna levels, and enhances global protein synthesis Proceedings of the National Academy of Sciences of the United States of America 2005 102:1865-1870 DOI:10.1073/pnas.0409764102 PMID:15684048 PMCID:PMC548588
- Chappell, S. A., Edelman, G. M., Mauro, V. P. Biochemical and functional analysis of a 9-nt rna sequence that affects translation efficiency in eukaryotic cells Proceedings of the National Academy of Sciences of the United States of America 2004 101:9590-9594 DOI:10.1073/pnas.0308759101 PMID:15210968 PMCID:PMC470719
- Rogers, G. W., Edelman, G. M., Mauro, V. P. Differential utilization of upstream augs in the beta-secretase mrna suggests that a shunting mechanism regulates translation Proceedings of the National Academy of Sciences of the United States of America 2004 101:2794-2799 DOI:10.1073/pnas.0308576101 PMID:14981268 PMCID:PMC365699
- Chappell, S. A., Mauro, V. P. The internal ribosome entry site (ires) contained within the rna-binding motif protein 3 (rbm3) mrna is composed of functionally distinct elements Journal of Biological Chemistry 2003 278:33793-33800 DOI:10.1074/jbc.M303495200 PMID:12824175
- Zhou, W., Edelman, G. M., Mauro, V. P. Isolation and identification of short nucleotide sequences that affect translation initiation in saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America 2003 100:4457-4462 DOI:10.1073/pnas.0437993100 PMID:12679518 PMCID:PMC153577
- Mauro, V. P., Edelman, G. M. The ribosome filter hypothesis Proceedings of the National Academy of Sciences of the United States of America 2002 99:12031-12036 DOI:10.1073/pnas.192442499 PMID:12221294 PMCID:PMC129393
- Chappell, S. A., Owens, G. C., Mauro, V. P. A 5' leader of Rbm3, a cold stress-induced mRNA, mediates internal initiation of translation with increased efficiency under conditions of mild hypothermia Journal of Biological Chemistry 2001 276:36917-36922 DOI:10.1074/jbc.M106008200 PMID:11470798
- Pinkstaff, J. K., Chappell, S. A., Mauro, V. P., Edelman, G. M., Krushel, L. A. Internal initiation of translation of five dendritically localized neuronal mrnas Proceedings of the National Academy of Sciences of the United States of America 2001 98:2770-2775 DOI:10.1073/pnas.051623398 PMID:11226315 PMCID:PMC30214
- Owens, G. C., Chappell, S. A., Mauro, V. P., Edelman, G. M. Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides Proceedings of the National Academy of Sciences of the United States of America 2001 98:1471-1476 DOI:10.1073/pnas.98.4.1471 PMID:11171975 PMCID:PMC29281
- Zhou, W., Edelman, G. M., Mauro, V. P. Transcript leader regions of two saccharomyces cerevisiae mrnas contain internal ribosome entry sites that function in living cells Proceedings of the National Academy of Sciences of the United States of America 2001 98:1531-1536 DOI:10.1073/pnas.98.4.1531 PMID:11171985 PMCID:PMC29291
- Chappell, S. A., Edelman, G. M., Mauro, V. P. A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity Proceedings of the National Academy of Sciences of the United States of America 2000 97:1536-1541 DOI:10.1073/pnas.97.4.1536 PMID:10677496 PMCID:PMC26470
- Hu, M. C. Y., Tranque, P., Edelman, G. M., Mauro, V. P. Rrna-complementarity in the 5 ' untranslated region of mrna specifying the gtx homeodomain protein: Evidence that base-pairing to 18s rrna affects translational efficiency Proceedings of the National Academy of Sciences of the United States of America 1999 96:1339-1344 DOI:10.1073/pnas.96.4.1339 PMID:9990025
- Tranque, P., Hu, M. C. Y., Edelman, G. M., Mauro, V. P. Rrna complementarity within mrnas: A possible basis for mrna-ribosome interactions and translational control Proceedings of the National Academy of Sciences of the United States of America 1998 95:12238-12243 DOI:10.1073/pnas.95.21.12238 PMID:9770470
- Crossin, K. L., Tai, M. H., Krushel, L. A., Mauro, V. P. Glucocorticoid receptor pathways are involved in the inhibition of astrocyte proliferation Proceedings of the National Academy of Sciences of the United States of America 1997 94:2687-2692 DOI:10.1073/pnas.94.6.2687 PMID:9122257
- Mauro, V. P., Edelman, G. M. Rrna-like sequences occur in diverse primary transcripts: Implications for the control of gene expression Proceedings of the National Academy of Sciences of the United States of America 1997 94:422-427 DOI:10.1073/pnas.94.2.422 PMID:9012798
- Tranque, P., Crossin, K. L., Cirelli, C., Edelman, G. M., Mauro, V. P. Identification and characterization of a ring zinc finger gene (c-rzf) expressed in chicken embryo cells Proceedings of the National Academy of Sciences of the United States of America 1996 93:3105-3109 DOI:10.1073/pnas.93.7.3105 PMID:8610176
- Mauro, V. P., Wood, I. C., Krushel, L., Crossin, K. L., Edelman, G. M. Cell-adhesion alters gene-transcription in chicken-embryo brain-cells and mouse embryonal carcinoma-cells Proceedings of the National Academy of Sciences of the United States of America 1994 91:2868-2872 DOI:10.1073/pnas.91.7.2868 PMID:8146202
- Mauro, V. P., Krushel, L. A., Cunningham, B. A., Edelman, G. M. Homophilic and heterophilic binding activities of nr-cam, a nervous-system cell-adhesion molecule Journal of Cell Biology 1992 119:191-202 DOI:10.1083/jcb.119.1.191 PMID:1527169
- Grumet, M., Mauro, V., Burgoon, M. P., Edelman, G. M., Cunningham, B. A. Structure of a new nervous-system glycoprotein, nr-cam, and its relationship to subgroups of neural cell-adhesion molecules Journal of Cell Biology 1991 113:1399-1412 DOI:10.1083/jcb.113.6.1399 PMID:2045418
- Burgoon, M. P., Grumet, M., Mauro, V., Edelman, G. M., Cunningham, B. A. Structure of the chicken neuron-glia cell-adhesion molecule, ng-cam - origin of the polypeptides and relation to the ig superfamily Journal of Cell Biology 1991 112:1017-1029 DOI:10.1083/jcb.112.5.1017 PMID:1705558
- Verma, D. P. S., Fortin, M. G., Stanley, J., Mauro, V. P., Purohit, S., Morrison, N. Nodulins and nodulin genes of glycine-max - a perspective Plant Molecular Biology 1986 7:51-61 DOI:10.1007/bf00020131 PMID:24302157
- Mauro, V. P., Nguyen, T., Katinakis, P., Verma, D. P. S. Primary structure of the soybean nodulin-23 gene and potential regulatory elements in the 5'-flanking regions of nodulin and leghemoglobin genes Nucleic Acids Research 1985 13:239-249 DOI:10.1093/nar/13.1.239 PMID:3839073