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Mauro, Vincent
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Mauro, Vincent

Faculty Member
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Positions

  • 2017 - Professional Scientific Collaborator, Molecular Medicine , Scripps Research
  • 2015 - 2017 Professional Scientific Collaborator, Cell and Molecular Biology (CMB) , Scripps Research
  • 2013 - 2015 Associate Professor of Neurobiology, Cell and Molecular Biology (CMB) , Scripps Research
  • - 2012 Associate Professor of Neurobiology, Neurobiology , Scripps Research
Dr. Vincent Mauro studies the regulation of gene expression at the level of protein synthesis, focusing on elements that affect translation initiation, including elements contained within mRNAs, such as internal ribosomal entry sites (IRESes), and elements contained within ribosomes, such as ribosomal RNA.

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  • vmauro@scripps.edu
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Publications

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    • Mauro, V. P. Codon optimization in the production of recombinant biotherapeutics: potential risks and considerations BioDrugs  2018 32:69-81  DOI:10.1007/s40259-018-0261-x  PMID:29392566
    • Sullivan, C. J., Pendleton, E. D., Sasmor, H. H., Hicks, W. L., Farnum, J. B., Muto, M., Amendt, E. M., Schoborg, J. A., Martin, R. W., Clark, L. G., Anderson, M. J., Choudhury, A., et al. A cell-free expression and purification process for rapid production of protein biologics Biotechnology Journal  2016 11:238-248  DOI:10.1002/biot.201500214  PMID:26427345
    • Mauro, V. P., Matsuda, D. Translation regulation by ribosomes: Increased complexity and expanded scope RNA Biology  2016 13:748-755  DOI:10.1080/15476286.2015.1107701  PMID:26513496  PMCID:PMC5013984
    • Mauro, V. P., Chappell, S. A. A critical analysis of codon optimization in human therapeutics Trends in Molecular Medicine  2014 20:604-613  DOI:10.1016/j.molmed.2014.09.003  PMID:25263172  PMCID:PMC4253638
    • Matsuda, D., Mauro, V. P. Base pairing between hepatitis C virus RNA and 18S rRNA is required for IRES-dependent translation initiation in vivo Proceedings of the National Academy of Sciences of the United States of America  2014 111:15385-15389  DOI:10.1073/pnas.1413472111  PMID:25313046  PMCID:PMC4217472
    • Burman, L. G., Mauro, V. P. Analysis of rrna processing and translation in mammalian cells using a synthetic 18s rrna expression system Nucleic Acids Research  2012 40:8085-8098  DOI:10.1093/nar/gks530  PMID:22718970  PMCID:PMC3439915
    • Matsuda, D., Mauro, V. P. Determinants of initiation codon selection during translation in mammalian cells PLoS One  2010 5:e15057  DOI:10.1371/journal.pone.0015057  PMID:21124832  PMCID:PMC2991327
    • Tahiri-Alaoui, A., Matsuda, D., Xu, H. T., Panagiotis, P., Burman, L., Lambeth, L. S., Petherbridge, L., James, W., Mauro, V., Nair, V. The 5' leader of the mRNA encoding the Marek's disease virus serotype 1 pp14 protein contains an intronic internal ribosome entry site with allosteric properties Journal of Virology  2009 83:12769-12778  DOI:10.1128/jvi.01010-09  PMID:19793814  PMCID:PMC2786844
    • Koh, D. C., Mauro, V. P. Reconciling contradictory reports regarding translation of BACE1 mRNA: initiation mechanism is altered by different expression systems RNA Biology  2009 6:54-58  DOI:10.4161/rna.6.1.7567  PMID:19106624
    • Panopoulos, P., Mauro, V. P. Antisense masking reveals contributions of mrna- rrna base pairing to translation of gtx and fgf2 mrnas Journal of Biological Chemistry  2008 283:33087-33093  DOI:10.1074/jbc.M804904200  PMID:18832380  PMCID:PMC2586266
    • Mauro, V. P., Edelman, G. M. The ribosome filter redux Cell Cycle  2007 6:2246-2251  DOI:10.4161/cc.6.18.4739  PMID:17890902  PMCID:PMC2930609
    • Chappell, S. A., Edelman, G. M., Mauro, V. P. Ribosomal tethering and clustering as mechanisms for translation initiation Proceedings of the National Academy of Sciences of the United States of America  2006 103:18077-18082  DOI:10.1073/pnas.0608212103  PMID:17110442  PMCID:PMC1838709
    • Chappell, S. A., Dresios, J., Edelman, G. M., Mauro, V. P. Ribosomal shunting mediated by a translational enhancer element that base pairs to 18s rrna Proceedings of the National Academy of Sciences of the United States of America  2006 103:9488-9493  DOI:10.1073/pnas.0603597103  PMID:16769881  PMCID:PMC1480434
    • Dresios, J., Chappell, S. A., Zhou, W., Mauro, V. P. An mrna-rrna base-pairing mechanism for translation initiation in eukaryotes Nature Structural & Molecular Biology  2006 13:30-34  DOI:10.1038/nsmb1031  PMID:16341227
    • Zhou, W., Edelman, G. M., Mauro, V. P. A positive feedback vector for identification of nucleotide sequences that enhance translation Proceedings of the National Academy of Sciences of the United States of America  2005 102:6273-6278  DOI:10.1073/pnas.0409892102  PMID:15845766  PMCID:PMC1088366
    • Wang, Y. L., Iyer, M., Annala, A. J., Chappell, S., Mauro, V., Gambhir, S. S. Noninvasive monitoring of target gene expression by imaging reporter gene expression in living animals using improved bicistronic vectors Journal of Nuclear Medicine  2005 46:667-674  PMID:15809490
    • Dresios, J., Aschrafi, A., Owens, G. C., Vanderklish, P. W., Edelman, G. M., Mauro, V. P. Cold stress-induced protein rbm3 binds 60s ribosomal subunits, alters rnicrorna levels, and enhances global protein synthesis Proceedings of the National Academy of Sciences of the United States of America  2005 102:1865-1870  DOI:10.1073/pnas.0409764102  PMID:15684048  PMCID:PMC548588
    • Chappell, S. A., Edelman, G. M., Mauro, V. P. Biochemical and functional analysis of a 9-nt rna sequence that affects translation efficiency in eukaryotic cells Proceedings of the National Academy of Sciences of the United States of America  2004 101:9590-9594  DOI:10.1073/pnas.0308759101  PMID:15210968  PMCID:PMC470719
    • Rogers, G. W., Edelman, G. M., Mauro, V. P. Differential utilization of upstream augs in the beta-secretase mrna suggests that a shunting mechanism regulates translation Proceedings of the National Academy of Sciences of the United States of America  2004 101:2794-2799  DOI:10.1073/pnas.0308576101  PMID:14981268  PMCID:PMC365699
    • Chappell, S. A., Mauro, V. P. The internal ribosome entry site (ires) contained within the rna-binding motif protein 3 (rbm3) mrna is composed of functionally distinct elements Journal of Biological Chemistry  2003 278:33793-33800  DOI:10.1074/jbc.M303495200  PMID:12824175
    • Zhou, W., Edelman, G. M., Mauro, V. P. Isolation and identification of short nucleotide sequences that affect translation initiation in saccharomyces cerevisiae Proceedings of the National Academy of Sciences of the United States of America  2003 100:4457-4462  DOI:10.1073/pnas.0437993100  PMID:12679518  PMCID:PMC153577
    • Mauro, V. P., Edelman, G. M. The ribosome filter hypothesis Proceedings of the National Academy of Sciences of the United States of America  2002 99:12031-12036  DOI:10.1073/pnas.192442499  PMID:12221294  PMCID:PMC129393
    • Chappell, S. A., Owens, G. C., Mauro, V. P. A 5' leader of Rbm3, a cold stress-induced mRNA, mediates internal initiation of translation with increased efficiency under conditions of mild hypothermia Journal of Biological Chemistry  2001 276:36917-36922  DOI:10.1074/jbc.M106008200  PMID:11470798
    • Pinkstaff, J. K., Chappell, S. A., Mauro, V. P., Edelman, G. M., Krushel, L. A. Internal initiation of translation of five dendritically localized neuronal mrnas Proceedings of the National Academy of Sciences of the United States of America  2001 98:2770-2775  DOI:10.1073/pnas.051623398  PMID:11226315  PMCID:PMC30214
    • Owens, G. C., Chappell, S. A., Mauro, V. P., Edelman, G. M. Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides Proceedings of the National Academy of Sciences of the United States of America  2001 98:1471-1476  DOI:10.1073/pnas.98.4.1471  PMID:11171975  PMCID:PMC29281
    • Zhou, W., Edelman, G. M., Mauro, V. P. Transcript leader regions of two saccharomyces cerevisiae mrnas contain internal ribosome entry sites that function in living cells Proceedings of the National Academy of Sciences of the United States of America  2001 98:1531-1536  DOI:10.1073/pnas.98.4.1531  PMID:11171985  PMCID:PMC29291
    • Chappell, S. A., Edelman, G. M., Mauro, V. P. A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity Proceedings of the National Academy of Sciences of the United States of America  2000 97:1536-1541  DOI:10.1073/pnas.97.4.1536  PMID:10677496  PMCID:PMC26470
    • Hu, M. C. Y., Tranque, P., Edelman, G. M., Mauro, V. P. Rrna-complementarity in the 5 ' untranslated region of mrna specifying the gtx homeodomain protein: Evidence that base-pairing to 18s rrna affects translational efficiency Proceedings of the National Academy of Sciences of the United States of America  1999 96:1339-1344  DOI:10.1073/pnas.96.4.1339  PMID:9990025
    • Tranque, P., Hu, M. C. Y., Edelman, G. M., Mauro, V. P. Rrna complementarity within mrnas: A possible basis for mrna-ribosome interactions and translational control Proceedings of the National Academy of Sciences of the United States of America  1998 95:12238-12243  DOI:10.1073/pnas.95.21.12238  PMID:9770470
    • Crossin, K. L., Tai, M. H., Krushel, L. A., Mauro, V. P. Glucocorticoid receptor pathways are involved in the inhibition of astrocyte proliferation Proceedings of the National Academy of Sciences of the United States of America  1997 94:2687-2692  DOI:10.1073/pnas.94.6.2687  PMID:9122257
    • Mauro, V. P., Edelman, G. M. Rrna-like sequences occur in diverse primary transcripts: Implications for the control of gene expression Proceedings of the National Academy of Sciences of the United States of America  1997 94:422-427  DOI:10.1073/pnas.94.2.422  PMID:9012798
    • Tranque, P., Crossin, K. L., Cirelli, C., Edelman, G. M., Mauro, V. P. Identification and characterization of a ring zinc finger gene (c-rzf) expressed in chicken embryo cells Proceedings of the National Academy of Sciences of the United States of America  1996 93:3105-3109  DOI:10.1073/pnas.93.7.3105  PMID:8610176
    • Mauro, V. P., Wood, I. C., Krushel, L., Crossin, K. L., Edelman, G. M. Cell-adhesion alters gene-transcription in chicken-embryo brain-cells and mouse embryonal carcinoma-cells Proceedings of the National Academy of Sciences of the United States of America  1994 91:2868-2872  DOI:10.1073/pnas.91.7.2868  PMID:8146202
    • Mauro, V. P., Krushel, L. A., Cunningham, B. A., Edelman, G. M. Homophilic and heterophilic binding activities of nr-cam, a nervous-system cell-adhesion molecule Journal of Cell Biology  1992 119:191-202  DOI:10.1083/jcb.119.1.191  PMID:1527169
    • Grumet, M., Mauro, V., Burgoon, M. P., Edelman, G. M., Cunningham, B. A. Structure of a new nervous-system glycoprotein, nr-cam, and its relationship to subgroups of neural cell-adhesion molecules Journal of Cell Biology  1991 113:1399-1412  DOI:10.1083/jcb.113.6.1399  PMID:2045418
    • Burgoon, M. P., Grumet, M., Mauro, V., Edelman, G. M., Cunningham, B. A. Structure of the chicken neuron-glia cell-adhesion molecule, ng-cam - origin of the polypeptides and relation to the ig superfamily Journal of Cell Biology  1991 112:1017-1029  DOI:10.1083/jcb.112.5.1017  PMID:1705558
    • Verma, D. P. S., Fortin, M. G., Stanley, J., Mauro, V. P., Purohit, S., Morrison, N. Nodulins and nodulin genes of glycine-max - a perspective Plant Molecular Biology  1986 7:51-61  DOI:10.1007/bf00020131  PMID:24302157
    • Mauro, V. P., Nguyen, T., Katinakis, P., Verma, D. P. S. Primary structure of the soybean nodulin-23 gene and potential regulatory elements in the 5'-flanking regions of nodulin and leghemoglobin genes Nucleic Acids Research  1985 13:239-249  DOI:10.1093/nar/13.1.239  PMID:3839073
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Research

research overview

  • Translational Control of Gene Expression

    Gene expression underlies all cellular properties and depends on the ability of genomic DNA to be transcribed into messenger RNA (mRNA) and translated into protein. However, for many genes, the presence of the mRNA does not insure protein production because of mechanisms that affect its translation. Work in our laboratory is focused on understanding the basic mechanisms by which ribosomes, the translation machinery of the cell, initiate and regulate the translation of cellular mRNAs. In earlier studies, we showed that segments of some mRNAs could bind to particular sites on ribosomes and affect translation efficiency, initiation, and competition. A particular emphasis of our recent work has been on testing the notion that direct interactions between ribosomal subunits and mRNAs may be a basis for internal initiation of translation. This mechanism of initiating translation appears to be used by some viral and cellular mRNAs under conditions where the translation of most other mRNAs is blocked or inefficient, for example, during mitosis, near synapses in neurons, and under conditions of mild hypothermia.

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Background

education and training

  • Ph.D., McGill University 1987
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Contact

full name

  • Vincent Peter Mauro

geographic location

  • Scripps California 

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