academic article

• Stoveken, H. M., Zucca, S., Masuho, I., Grill, B., Martemyanov, K. A. The orphan receptor GPR139 signals via G(q/11)to oppose opioid effects Journal of Biological Chemistry  2020 295:10822-10830  DOI:10.1074/jbc.AC120.014770  PMID:32576659  PMCID:PMC7397111
• Anderson, A., Masuho, I., de Velasco, E. M. F., Nakano, A., Birnbaumer, L., Martemyanov, K. A., Wickman, K. GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells Proceedings of the National Academy of Sciences of the United States of America  2020 117:14522-14531  DOI:10.1073/pnas.2001270117  PMID:32513692  PMCID:PMC7322085
• Masuho, I., Skamangas, N. K., Martemyanov, K. A. Live Cell Optical Assay for Precise Characterization of Receptors Coupling to Gα12 Basic & Clinical Pharmacology & Toxicology  2020 126:88-95  DOI:10.1111/bcpt.13228  PMID:30916867  PMCID:PMC6764917
• Xu, L., Bolch, S. N., Santiago, C. P., Dyka, F. M., Akil, O., Lobanova, E. S., Wang, Y., Martemyanov, K. A., Hauswirth, W. W., Smith, W. C., Handa, J. T., Blackshaw, S., et al. Clarin-1 expression in adult mouse and human retina highlights a role of Muller glia in Usher syndrome Journal of Pathology  2020 250:195-204  DOI:10.1002/path.5360  PMID:31625146  PMCID:PMC7003947
• Bartoszek, A., Von Moo, E., Binienda, A., Fabisiak, A., Krajewska, J. B., Mosinska, P., Niewinna, K., Tarasiuk, A., Martemyanov, K., Salaga, M., Fichna, J. Free Fatty Acid Receptors as new potential therapeutic target in inflammatory bowel diseases Pharmacological Research  2020 152  DOI:10.1016/j.phrs.2019.104604  PMID:31846762
• Masuho, I., Balaji, S., Muntean, B. S., Skamangas, N. K., Chavali, S., Tesmer, J. J. G., Babu, M. M., Martemyanov, K. A. A Global Map of G Protein Signaling Regulation by RGS Proteins Cell  2020 183:503-521  DOI:10.1016/j.cell.2020.08.052  PMID:33007266  PMCID:PMC7572916
• Cao, Y., Wang, Y. C., Dunn, H. A., Orlandi, C., Shultz, N., Kamasawa, N., Fitzpatrick, D., Li, W., Zeitz, C., Hauswirth, W., Martemyanov, K. A. Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors Proceedings of the National Academy of Sciences of the United States of America  2020 117:23914-23924  DOI:10.1073/pnas.2009940117  PMID:32879010  PMCID:PMC7519344
• Doyle, T. B., Muntean, B. S., Ejendal, K. F., Hayes, M. P., Soto-Velasquez, M., Martemyanov, K. A., Dessauer, C. W., Hu, C. D., Watts, V. J. Identification of novel adenylyl cyclase 5 (AC5) signaling networks in D1 and D2 medium spiny neurons using bimolecular fluorescence complementation screening Cells  2019 8  DOI:10.3390/cells8111468  PMID:31752385  PMCID:PMC6912275
• Muntean, B. S., Dao, M. T., Martemyanov, K. A. Allostatic changes in the cAMP system drive opioid-induced adaptation in striatal dopamine signaling Cell Reports  2019 29:946-960  DOI:10.1016/j.celrep.2019.09.034  PMID:31644915
• Dunn, H. A., Orlandi, C., Martemyanov, K. A. Beyond the ligand: extracellular and transcellular G protein-coupled receptor complexes in physiology and pharmacology Pharmacological Reviews  2019 71:503-519  DOI:10.1124/pr.119.018044  PMID:31515243  PMCID:PMC6742926
• Sutton, L. P., Muntean, B. S., Ostrovskaya, O., Zucca, S., Dao, M., Orlandi, C., Song, C., Xie, K., Martemyanov, K. A. NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control PLoS Biology  2019 17  DOI:10.1371/journal.pbio.3000477  PMID:31600280  PMCID:PMC6805008
• Wang, D., Stoveken, H. M., Zucca, S., Dao, M., Orlandi, C., Song, C. H., Masuho, I., Johnston, C., Opperman, K. J., Giles, A. C., Gill, M. S., Lundquist, E. A., et al. Genetic behavioral screen identifies an orphan anti-opioid system Science  2019 365:1267-+  DOI:10.1126/science.aau2078  PMID:31416932
• Cirnaru, M. D., Melis, C., Fanutza, T., Naphade, S., Tshilenge, K. T., Muntean, B. S., Martemyanov, K. A., Plotkin, J. L., Ellerby, L. M., Ehrlich, M. E. Nuclear receptor Nr4a1 regulates striatal striosome development and dopamine D1 receptor signaling eNeuro  2019 6:Unsp eneuro.0305-19.2019  DOI:10.1523/eneuro.0305-19.2019  PMID:31541002  PMCID:PMC6787343
• Song, C., Orlandi, C., Sutton, L. P., Martemyanov, K. A. The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex Journal of Biological Chemistry  2019 294:13145-13157  DOI:10.1074/jbc.RA119.007533  PMID:31311860  PMCID:PMC6721952
• Xu, Z. X., Tan, J. W., Xu, H., Hill, C. J., Ostrovskaya, O., Martemyanov, K. A., Xu, B. Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling Nature Communications  2019 10  DOI:10.1038/s41467-019-11575-1  PMID:31399584  PMCID:PMC6689033
• Itakura, T., Webster, A., Chintala, S. K., Wang, Y., Gonzalez Jr., J. M., Tan, J. C., Vranka, J. A., Acott, T., Craft, C. M., Saber, M. E. S., Jeong, S., Stamer, W. D., et al. GPR158 in the visual system: homeostatic role in regulation of intraocular pressure Journal of Ocular Pharmacology and Therapeutics  2019 35:203-215  DOI:10.1089/jop.2018.0135  PMID:30855200
• Orlandi, C., Sutton, L. P., Muntean, B. S., Song, C., Martemyanov, K. A. Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors Neuropsychopharmacology  2019 44:642-653  DOI:10.1038/s41386-018-0238-y  PMID:30546127  PMCID:PMC6333837
• Patil, D. N., Rangarajan, E. S., Novick, S. J., Pascal, B. D., Kojetin, D. J., Griffin, P. R., Izard, T., Martemyanov, K. A. Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex Elife  2018 7  DOI:10.7554/eLife.42150  PMID:30540250  PMCID:PMC6310461
• Ostrovskaya, O. I., Orlandi, C., Fajardo-Serrano, A., Young, S. M., Lujan, R., Martemyanov, K. A. Inhibitory signaling to ion channels in hippocampal neurons is differentially regulated by alternative macromolecular complexes of RGS7 Journal of Neuroscience  2018 38:10002-10015  DOI:10.1523/jneurosci.1378-18.2018  PMID:30315127  PMCID:PMC6234300
• Condomitti, G., Wierda, K. D., Schroeder, A., Rubio, S. E., Vennekens, K. M., Orlandi, C., Martemyanov, K. A., Gounko, N. V., Savas, J. N., de Wit, J. An input-specific orphan receptor GPR158-HSPG interaction organizes hippocampal mossy fiber-CA3 synapses Neuron  2018 100:201-215  DOI:10.1016/j.neuron.2018.08.038  PMID:30290982
• Orlandi, C., Omori, Y., Wang, Y., Cao, Y., Ueno, A., Roux, M. J., Condomitti, G., de Wit, J., Kanagawa, M., Furukawa, T., Martemyanov, K. A. Transsynaptic binding of orphan receptor GPR179 to dystroglycan-pikachurin complex is essential for the synaptic organization of photoreceptors Cell Reports  2018 25:130-145  DOI:10.1016/j.celrep.2018.08.068  PMID:30282023
• Song, C. H., Anderson, G. R., Sutton, L. P., Dao, M., Martemyanov, K. A. Selective role of RGS9-2 in regulating retrograde synaptic signaling of indirect pathway medium spiny neurons in dorsal striatum Journal of Neuroscience  2018 38:7120-7131  DOI:10.1523/jneurosci.0493-18.2018  PMID:30006367  PMCID:PMC6083461
• Masuho, I., Chavali, S., Muntean, B. S., Skamangas, N. K., Simonyan, K., Patil, D. N., Kramer, G. M., Ozelius, L., Babu, M. M., Martemyanov, K. A. Molecular deconvolution platform to establish disease mechanisms by surveying GPCR signaling Cell Reports  2018 24:557-568  DOI:10.1016/j.celrep.2018.06.080  PMID:30021154  PMCID:PMC6077248
• Gulati, S., Jin, H., Masuho, I., Orban, T., Cai, Y., Pardon, E., Martemyanov, K. A., Kiser, P. D., Stewart, P. L., Ford, C. P., Steyaert, J., Palczewski, K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor Nature Communications  2018 9  DOI:10.1038/s41467-018-04432-0  PMID:29777099  PMCID:PMC5959942
• Martemyanov, K. A., Garcia-Marcos, M. Making useful gadgets with miniaturized G proteins Journal of Biological Chemistry  2018 293:7474-7475  DOI:10.1074/jbc.H118.002879  PMID:29752421  PMCID:PMC5949992
• Dunn, H. A., Patil, D. N., Cao, Y., Orlandi, C., Martemyanov, K. A. Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans Proceedings of the National Academy of Sciences of the United States of America  2018 115:5022-5027  DOI:10.1073/pnas.1722498115  PMID:29686062  PMCID:PMC5948991
• Marcott, P. F., Gong, S., Donthamsetti, P., Grinnell, S. G., Nelson, M. N., Newman, A. H., Birnbaumer, L., Martemyanov, K. A., Javitch, J. A., Ford, C. P. Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens Neuron  2018 98:575-587  DOI:10.1016/j.neuron.2018.03.038  PMID:29656874
• Kulkarni, K., Xie, X., de Velasco, E. M. F., Anderson, A., Martemyanov, K. A., Wickman, K., Tolkacheva, E. G. The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart PLoS One  2018 13  DOI:10.1371/journal.pone.0193798  PMID:29668674  PMCID:PMC5905881
• Muntean, B. S., Patil, D. N., Madoux, F., Fossetta, J., Scampavia, L., Spicer, T. P., Martemyanov, K. A. A high-throughput time-resolved fluorescence energy transfer assay to screen for modulators of RGS7/Gβ5/R7BP complex Assay and Drug Development Technologies  2018 16:150-161  DOI:10.1089/adt.2017.839  PMID:29658790  PMCID:PMC5906730
• Sarria, I., Cao, Y., Wang, Y., Ingram, N. T., Orlandi, C., Kamasawa, N., Kolesnikov, A. V., Pahlberg, J., Kefalov, V. J., Sampath, A. P., Martemyanov, K. A. LRIT1 modulates adaptive changes in synaptic communication of cone photoreceptors Cell Reports  2018 22:3562-3573  DOI:10.1016/j.celrep.2018.03.008  PMID:29590623  PMCID:PMC5902029
• Sutton, L. P., Orlandi, C., Song, C., Oh, W. C., Muntean, B. S., Xie, K., Filippini, A., Xie, X., Satterfield, R., Yaeger, J. D. W., Renner, K. J., Young Jr., S. M., et al. Orphan receptor GPR158 controls stress-induced depression Elife  2018 7  DOI:10.7554/eLife.33273  PMID:29419376  PMCID:PMC5823542
• Anderson, A., Kulkarni, K., de Velasco, E. M. F., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K. A., Tolkacheva, E. G., Wickman, K. Expression and relevance of the G protein-gated K+ channel in the mouse ventricle Scientific Reports  2018 8  DOI:10.1038/s41598-018-19719-x  PMID:29352184  PMCID:PMC5775354
• Qutob, N., Masuho, I., Alon, M., Emmanuel, R., Cohen, I., Di Pizio, A., Madore, J., Elkahloun, A., Ziv, T., Levy, R., Gartner, J. J., Hill, V. K., et al. RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells Scientific Reports  2018 8  DOI:10.1038/s41598-017-18851-4  PMID:29330521  PMCID:PMC5766496
• Hauser, A. S., Chavali, S., Masuho, I., Jahn, L. J., Martemyanov, K. A., Gloriam, D. E., Babu, M. M. Pharmacogenomics of GPCR drug targets Cell  2018 172:41-54  DOI:10.1016/j.cell.2017.11.033  PMID:29249361  PMCID:PMC5766829
• Muntean, B. S., Zucca, S., MacMullen, C. M., Dao, M. T., Johnston, C., Iwamoto, H., Blakely, R. D., Davis, R. L., Martemyanov, K. A. Interrogating the spatiotemporal landscape of neuromodulatory GPCR signaling by real-time imaging of cAMP in intact neurons and circuits Cell Reports  2018 22:255-268  DOI:10.1016/j.celrep.2017.12.022  PMID:29298426  PMCID:PMC5761078
• Himmelreich, S., Masuho, I., Berry, J. A., MacMullen, C., Skamangas, N. K., Martemyanov, K. A., Davis, R. L. Dopamine receptor DAMB signals via Gq to mediate forgetting in Drosophila Cell Reports  2017 21:2074-2081  DOI:10.1016/j.celrep.2017.10.108  PMID:29166600
• Carmon, K. S., Gong, X., Yi, J., Wu, L., Thomas, A., Moore, C. M., Masuho, I., Timson, D. J., Martemyanov, K. A., Liu, Q. J. Y. LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway Journal of Biological Chemistry  2017 292:14989-15001  DOI:10.1074/jbc.M117.786798  PMID:28739799  PMCID:PMC5592675
• Wang, Y., Fehlhaber, K. E., Sarria, I., Cao, Y., Ingram, N. T., Guerrero-Given, D., Throesch, B., Baldwin, K., Kamasawa, N., Ohtsuka, T., Sampath, A. P., Martemyanov, K. A. The auxiliary calcium channel subunit α2δ4 is required for axonal elaboration, synaptic transmission, and wiring of rod photoreceptors Neuron  2017 93:1359-1374  DOI:10.1016/j.neuron.2017.02.021  PMID:28262416  PMCID:PMC5364038
• Lohmann, K., Masuho, I., Patil, D. N., Baumann, H., Hebert, E., Steinrucke, S., Trujillano, D., Skamangas, N. K., Dobricic, V., Huning, I., Gillessen-Kaesbach, G., Westenberger, A., et al. Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans Human Molecular Genetics  2017 26:1078-1086  DOI:10.1093/hmg/ddx018  PMID:28087732
• Neuille, M., Cao, Y., Caplette, R., Guerrero-Given, D., Thomas, C., Kamasawa, N., Sahel, J. A., Hamel, C. P., Audo, I., Picaud, S., Martemyanov, K. A., Zeitz, C. LRIT3 differentially affects connectivity and synaptic transmission of cones to ON- and OFF-bipolar Cells Investigative Ophthalmology & Visual Science  2017 58:1768-1778  DOI:10.1167/iovs.16-20745  PMID:28334377  PMCID:PMC5374884
• Martemyanov, K. A., Sampath, A. P. The transduction cascade in retinal ON-bipolar cells: signal processing and disease Annual Review of Vision Science  2017 3:25-51  DOI:10.1146/annurev-vision-102016-061338  PMID:28715957
• Aguado, C., Orlandi, C., Fajardo-Serrano, A., Gil-Minguez, M., Martemyanov, K. A., Lujan, R. Cellular and subcellular localization of the RGS7/Gβ5/R7BP complex in the cerebellar cortex Frontiers in Neuroanatomy  2016 10  DOI:10.3389/fnana.2016.00114  PMID:27965545  PMCID:PMC5127842
• Xie, K., Colgan, L. A., Dao, M. T., Muntean, B. S., Sutton, L. P., Orlandi, C., Boye, S. L., Boye, S. E., Shih, C. C., Li, Y., Xu, B., Smith, R. G., et al. NF1 is a direct G protein effector essential for opioid signaling to Ras in the striatum Current Biology  2016 26:2992-3003  DOI:10.1016/j.cub.2016.09.010  PMID:27773571  PMCID:PMC5121064
• Victoria, N. C., Marron Fernandez de Velasco, E., Ostrovskaya, O., Metzger, S., Xia, Z., Kotecki, L., Benneyworth, M. A., Zink, A. N., Martemyanov, K. A., Wickman, K. G protein-gated K+ channel ablation in forebrain pyramidal neurons selectively impairs fear learning Biological Psychiatry  2016 80:796-806  DOI:10.1016/j.biopsych.2015.10.004  PMID:26612516  PMCID:PMC4862939
• Sutton, L. P., Ostrovskaya, O., Dao, M., Xie, K., Orlandi, C., Smith, R., Wee, S., Martemyanov, K. A. Regulator of G-protein signaling 7 regulates reward behavior by controlling opioid signaling in the striatum Biological Psychiatry  2016 80:235-245  DOI:10.1016/j.biopsych.2015.07.026  PMID:26364547  PMCID:PMC4753143
• Chen, Y., Palczewska, G., Masuho, I., Gao, S., Jin, H., Dong, Z., Gieser, L., Brooks, M. J., Kiser, P. D., Kern, T. S., Martemyanov, K. A., Swaroop, A., et al. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration Science Signaling  2016 9  DOI:10.1126/scisignal.aag0245  PMID:27460988  PMCID:PMC4972460
• Tayou, J., Wang, Q., Jang, G. F., Pronin, A. N., Orlandi, C., Martemyanov, K. A., Crabb, J. W., Slepak, V. Z. Regulator of G protein signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by Gαo and R7-binding protein Journal of Biological Chemistry  2016 291:9133-9147  DOI:10.1074/jbc.M115.694075  PMID:26895961  PMCID:PMC4861480
• Salaga, M., Storr, M., Martemyanov, K. A., Fichna, J. RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives Bioessays  2016 38:344-354  DOI:10.1002/bies.201500118  PMID:26817719  PMCID:PMC4916644
• Dos Santos, C. O., Masuho, I., da Silva-Júnior, F. P., Barbosa, E. R., Silva, S. M. C. A., Borges, V., Ferraz, H. B., Rocha, M. S. G., Limongi, J. C. P., Martemyanov, K. A., de Carvalho Aguiar, P. Screening of GNAL variants in Brazilian patients with isolated dystonia reveals a novel mutation with partial loss of function Journal of Neurology  2016 263:665-668  DOI:10.1007/s00415-016-8026-2  PMID:26810727  PMCID:PMC4828253
• Muntean, B. S., Martemyanov, K. A. Association with the plasma membrane is sufficient for potentiating catalytic activity of regulators of G protein signaling (RGS) proteins of the R7 subfamily Journal of Biological Chemistry  2016 291:7195-7204  DOI:10.1074/jbc.M115.713446  PMID:26811338  PMCID:PMC4807299
• Xu, Y., Orlandi, C., Cao, Y., Yang, S., Choi, C. I., Pagadala, V., Birnbaumer, L., Martemyanov, K. A., Vardi, N. The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein G(o) Scientific Reports  2016 6  DOI:10.1038/srep20940  PMID:26883481  PMCID:PMC4756708
• Shamseldin, H. E., Masuho, I., Alenizi, A., Alyamani, S., Patil, D. N., Ibrahim, N., Martemyanov, K. A., Alkuraya, F. S. GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition Genome Biology  2016 17  DOI:10.1186/s13059-016-1061-6  PMID:27677260  PMCID:PMC5037613
• Sarria, I., Orlandi, C., McCall, M. A., Gregg, R. G., Martemyanov, K. A. Intermolecular interaction between anchoring subunits specify subcellular targeting and function of RGS proteins in retina ON-bipolar neurons Journal of Neuroscience  2016 36:2915-2925  DOI:10.1523/jneurosci.3833-15.2016  PMID:26961947  PMCID:PMC4783495
• Masuho, I., Ostrovskaya, O., Kramer, G. M., Jones, C. D., Xie, K., Martemyanov, K. A. Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors Science Signaling  2015 8:ra123  DOI:10.1126/scisignal.aab4068  PMID:26628681  PMCID:PMC4886239
• Xie, K., Masuho, I., Shih, C. C., Cao, Y., Sasaki, K., Lai, C. W. J., Han, P. L., Ueda, H., Dessauer, C. W., Ehrlich, M. E., Xu, B., Willardson, B. M., et al. Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling Elife  2015 4  DOI:10.7554/eLife.10451  PMID:26613416  PMCID:PMC4728126
• Cao, Y., Sarria, I., Fehlhaber, K. E., Kamasawa, N., Orlandi, C., James, K. N., Hazen, J. L., Gardner, M. R., Farzan, M., Lee, A., Baker, S., Baldwin, K., et al. Mechanism for selective synaptic wiring of rod photoreceptors into the retinal circuitry and its role in vision Neuron  2015 87:1248-1260  DOI:10.1016/j.neuron.2015.09.002  PMID:26402607  PMCID:PMC4583715
• Neuille, M., Morgans, C. W., Cao, Y., Orhan, E., Michiels, C., Sahel, J. A., Audo, I., Duvoisin, R. M., Martemyanov, K. A., Zeitz, C. LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation European Journal of Neuroscience  2015 42:1966-1975  DOI:10.1111/ejn.12959  PMID:25997951  PMCID:PMC4733627
• Orlandi, C., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Martemyanov, K. A. Orphan receptor GPR158 is an allosteric modulator of RGS7 catalytic activity with an essential role in dictating its expression and localization in the brain Journal of Biological Chemistry  2015 290:13622-13639  DOI:10.1074/jbc.M115.645374  PMID:25792749  PMCID:PMC4447942
• Martemyanov, K. A. G protein signaling in the retina and beyond: the Cogan lecture Investigative Ophthalmology & Visual Science  2014 55:8201-8207  DOI:10.1167/iovs.14-15928  PMID:25511392  PMCID:PMC4541486
• Ray, T. A., Heath, K. M., Hasan, N., Noel, J. M., Samuels, I. S., Martemyanov, K. A., Peachey, N. S., McCall, M. A., Gregg, R. G. GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells Journal of Neuroscience  2014 34:6334-6343  DOI:10.1523/jneurosci.4044-13.2014  PMID:24790204  PMCID:PMC4004817
• Ostrovskaya, O., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Wickman, K., Martemyanov, K. A. RGS7/G beta 5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABA(B)R-GIRK signaling Elife  2014 3:e02053  DOI:10.7554/eLife.02053  PMID:24755289  PMCID:PMC3988575
• Kumar, K. R., Lohmann, K., Masuho, I., Miyamoto, R., Ferbert, A., Lohnau, T., Kasten, M., Hagenah, J., Bruggemann, N., Graf, J., Munchau, A., Kostic, V. S., et al. Mutations in GNAL: a novel cause of craniocervical dystonia JAMA Neurology  2014 71:490-494  DOI:10.1001/jamaneurol.2013.4677  PMID:24535567  PMCID:PMC4237020
• Wydeven, N., Posokhova, E., Xia, Z. L., Martemyanov, K. A., Wickman, K. RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate Journal of Biological Chemistry  2014 289:2440-2449  DOI:10.1074/jbc.M113.520742  PMID:24318880  PMCID:PMC3900986
• Fajardo-Serrano, A., Wydeven, N., Young, D., Watanabe, M., Shigemoto, R., Martemyanov, K. A., Wickman, K., Lujan, R. Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons Hippocampus  2013 23:1231-1245  DOI:10.1002/hipo.22161  PMID:23804514  PMCID:PMC4060866
• Posokhova, E., Ng, D., Opel, A., Masuho, I., Tinker, A., Biesecker, L. G., Wickman, K., Martemyanov, K. A. Essential role of the m(2)R-RGS6-I-KACh pathway in controlling intrinsic heart rate variability PLoS One  2013 8:e76973  DOI:10.1371/journal.pone.0076973  PMID:24204714  PMCID:PMC3812209
• Orlandi, C., Cao, Y., Martemyanov, K. A. Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons Investigative Ophthalmology and Visual Science  2013 54:7153-7161  DOI:10.1167/iovs.13-12907  PMID:24114537  PMCID:PMC3813323
• Masuho, I., Xie, K., Martemyanov, K. A. Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells Journal of Biological Chemistry  2013 288:25129-25142  DOI:10.1074/jbc.M113.462283  PMID:23857581  PMCID:PMC3757177
• Fuchs, T., Saunders-Pullman, R., Masuho, I., Luciano, M. S., Raymond, D., Factor, S., Lang, A. E., Liang, T. W., Trosch, R. M., White, S., Ainehsazan, E., Herve, D., et al. Mutations in GNAL cause primary torsion dystonia Nature Genetics  2013 45:88-92  DOI:10.1038/ng.2496  PMID:23222958  PMCID:PMC3530620
• Xie, K. Q., Masuho, I., Brand, C., Dessauer, C. W., Martemyanov, K. A. The complex of G protein regulator RGS9-2 and G beta(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum Science Signaling  2012 5:ra63  DOI:10.1126/scisignal.2002922  PMID:22932702  PMCID:PMC3580943
• Orlandi, C., Posokhova, E., Masuho, I., Ray, T. A., Hasan, N., Gregg, R. G., Martemyanov, K. A. GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes Journal of Cell Biology  2012 197:711-719  DOI:10.1083/jcb.201202123  PMID:22689652  PMCID:PMC3373406
• Cao, Y., Pahlberg, J., Sarria, I., Kamasawa, N., Sampath, A. P., Martemyanov, K. A. Regulators of g protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons Proceedings of the National Academy of Sciences of the United States of America  2012 109:7905-7910  DOI:10.1073/pnas.1202332109  PMID:22547806  PMCID:PMC3356620
• Terzi, D., Cao, Y., Agrimaki, I., Martemyanov, K. A., Zachariou, V. R7BP modulates opiate analgesia and tolerance but not withdrawal Neuropsychopharmacology  2012 37:1005-1012  DOI:10.1038/npp.2011.284  PMID:22089315  PMCID:PMC3280654
• Xie, K. Q., Ge, S. C., Collins, V. E., Haynes, C. L., Renner, K. J., Meisel, R. L., Lujan, R., Martemyanov, K. A. G beta 5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems Psychopharmacology  2012 219:823-834  DOI:10.1007/s00213-011-2409-y  PMID:21766168  PMCID:PMC3260372
• Gopalakrishna, K. N., Doddapuneni, K., Boyd, K. K., Masuho, I., Martemyanov, K. A., Artemyev, N. O. Interaction of transducin with uncoordinated 119 protein (UNC119) implications for the model of transducin trafficking in rod photoreceptors Journal of Biological Chemistry  2011 286:28954-28962  DOI:10.1074/jbc.M111.268821  PMID:21712387  PMCID:PMC3190703
• Cao, Y., Posokhova, E., Martemyanov, K. A. TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner Journal of Neuroscience  2011 31:11521-11526  DOI:10.1523/jneurosci.1682-11.2011  PMID:21832182  PMCID:PMC3164511
• Xie, K. Q., Martemyanov, K. A. Control of striatal signaling by G protein regulators Frontiers in Neuroanatomy  2011 5:49  DOI:10.3389/fnana.2011.00049  PMID:21852966  PMCID:PMC3151604
• Masuho, I., Wakasugi-Masuho, H., Posokhova, E. N., Patton, J. R., Martemyanov, K. A. Type 5 G protein beta subunit (G beta 5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors Journal of Biological Chemistry  2011 286:21806-21813  DOI:10.1074/jbc.M111.241513  PMID:21511947  PMCID:PMC3122235
• Posokhova, E., Song, H., Belcastro, M., Higgins, L., Bigley, L. R., Michaud, N. A., Martemyanov, K. A., Sokolov, M. Disruption of the chaperonin containing TCP-1 function affects protein networks essential for rod outer segment morphogenesis and survival Molecular & Cellular Proteomics  2011 10:M110.000570  DOI:10.1074/mcp.M110.000570  PMID:20852191  PMCID:PMC3013443
• Porter, M. Y., Xie, K. Q., Pozharski, E., Koelle, M. R., Martemyanov, K. A. A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins Journal of Biological Chemistry  2010 285:41100-41112  DOI:10.1074/jbc.M110.163600  PMID:20959458  PMCID:PMC3003408
• Posokhova, E., Wydeven, N., Allen, K. L., Wickman, K., Martemyanov, K. A. RGS6/G beta 5 complex accelerates IKaCh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate Circulation Research  2010 107:1350-1354  DOI:10.1161/circresaha.110.224212  PMID:20884879  PMCID:PMC3014848
• Cao, Y., Kolesnikov, A. V., Masuho, I., Kefalov, V. J., Martemyanov, K. A. Membrane anchoring subunits specify selective regulation of RGS9/Gbeta5 GAP complex in photoreceptor neurons Journal of Neuroscience  2010 30:13784-13793  DOI:10.1523/jneurosci.1191-10.2010  PMID:20943919  PMCID:PMC2975674
• Xie, K. Q., Allen, K. L., Kourrich, S., Colon-Saez, J., Thomas, M. J., Wickman, K., Martemyanov, K. A. G beta 5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling Nature Neuroscience  2010 13:661-663  DOI:10.1038/nn.2549  PMID:20453851  PMCID:PMC2876203
• Panicker, L. M., Zhang, J. H., Posokhova, E., Gastinger, M. J., Martemyanov, K. A., Simonds, W. F. Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein Journal of Neurochemistry  2010 113:1101-1112  DOI:10.1111/j.1471-4159.2010.06616.x  PMID:20100282  PMCID:PMC2890294
• Posokhova, E., Uversky, V., Martemyanov, K. A. Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis Journal of Proteome Research  2010 9:1510-1521  DOI:10.1021/pr901022m  PMID:20095651  PMCID:PMC2890236
• Anderson, G. R., Cao, Y., Davidson, S., Truong, H. V., Pravetoni, M., Thomas, M. J., Wickman, K., Giesler, G. J., Martemyanov, K. A. R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine Neuropsychopharmacology  2010 35:1040-1050  DOI:10.1038/npp.2009.212  PMID:20043004  PMCID:PMC2887292
• Roloff, A. M., Anderson, G. R., Martemyanov, K. A., Thayer, S. A. Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity Journal of Neuroscience  2010 30:3072-3081  DOI:10.1523/jneurosci.4603-09.2010  PMID:20181604  PMCID:PMC2843151
• Masuho, I., Celver, J., Kovoor, A., Martemyanov, K. A. Membrane anchor GTPase-accelerating protein activity of RGS11.G beta(5) complex and accelerates inactivation of the mGluR6-G(o) signaling Journal of Biological Chemistry  2010 285:4781-4787  DOI:10.1074/jbc.M109.058511  PMID:20007977  PMCID:PMC2836083
• Cao, Y., Masuho, I., Okawa, H., Xie, K. Q., Asami, J., Kammermeier, P. J., Maddox, D. M., Furukawa, T., Inoue, T., Sampath, A. P., Martemyanov, K. A. Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons Journal of Neuroscience  2009 29:9301-9313  DOI:10.1523/jneurosci.1367-09.2009  PMID:19625520  PMCID:PMC2731308
• Anderson, G. R., Posokhova, E., Martemyanov, K. A. The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling Cell Biochemistry and Biophysics  2009 54:33-46  DOI:10.1007/s12013-009-9052-9  PMID:19521673  PMCID:PMC2827338
• Anderson, G. R., Lujan, R., Martemyanov, K. A. Changes in striatal signaling induce remodeling of RGS complexes containing G beta 5 and R7BP subunits Molecular and Cellular Biology  2009 29:3033-3044  DOI:10.1128/mcb.01449-08  PMID:19332565  PMCID:PMC2682020
• Martemyanov, K. A., Krispel, C. M., Lishko, P. V., Burns, M. E., Arshavsky, V. Y. Functional comparison of RGS9 splice isoforms in a living cell Proceedings of the National Academy of Sciences of the United States of America  2008 105:20988-20993  DOI:10.1073/pnas.0808941106  PMID:19098104  PMCID:PMC2634932
• Kim, H. J., Martemyanov, K. A., Thayer, S. A. Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death Journal of Neuroscience  2008 28:12604-12613  DOI:10.1523/jneurosci.2958-08.2008  PMID:19036954  PMCID:PMC2678679
• Cao, Y., Song, H. M., Okawa, H., Sampath, A. P., Sokolov, M., Martemyanov, K. A. Targeting of RGS7/G beta 5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP Journal of Neuroscience  2008 28:10443-10449  DOI:10.1523/jneurosci.3282-08.2008  PMID:18842904  PMCID:PMC2587022
• Anderson, G. R., Lujan, R., Semenov, A., Pravetoni, M., Posokhova, E. N., Song, J. H., Uversky, V., Chen, C. K., Wickman, K., Martemyanov, K. A. Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases Journal of Neuroscience  2007 27:14117-14127  DOI:10.1523/jneurosci.3884-07.2007  PMID:18094251
• Song, J. H., Song, H., Wensel, T. G., Sokolov, M., Martemyanov, K. A. Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina Molecular and Cellular Neuroscience  2007 35:311-319  DOI:10.1016/j.mcn.2007.03.006  PMID:17442586
• Anderson, G. R., Semenov, A., Song, J. H., Martemyanov, K. A. The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2 Journal of Biological Chemistry  2007 282:4772-4781  DOI:10.1074/jbc.M610518200  PMID:17158100
• Baker, S. A., Martemyanov, K. A., Shavkunov, A. S., Arshavsky, V. Y. Kinetic mechanism of RGS9-1 potentiation by R9AP Biochemistry  2006 45:10690-10697  DOI:10.1021/bi060376a  PMID:16939221
• Krispel, C. M., Chen, D., Melling, N., Chen, Y. J., Martemyanov, K. A., Quillinan, N., Arshavsky, V. Y., Wensel, T. G., Chen, C. K., Burns, M. E. RGS expression rate-limits recovery of rod photoresponses Neuron  2006 51:409-416  DOI:10.1016/j.neuron.2006.07.010  PMID:16908407
• Song, J. H., Waataja, J. J., Martemyanov, K. A. Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP Journal of Biological Chemistry  2006 281:15361-15369  DOI:10.1074/jbc.M600749200  PMID:16574655
• Grant, J. E., Guo, L. W., Vestling, M. M., Martemyanov, K. A., Arshavsky, V. Y., Ruoho, A. E. The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit Journal of Biological Chemistry  2006 281:6194-6202  DOI:10.1074/jbc.M509511200  PMID:16407279
• Guo, L. W., Hajipour, A. R., Gavala, M. L., Arbabian, M., Martemyanov, K. A., Arshavsky, V. Y., Ruoho, A. E. Sulfhydryl-reactive, cleavable, and radioiodinatable benzophenone photoprobes for study of protein-protein interaction Bioconjugate Chemistry  2005 16:685-693  DOI:10.1021/bc050016k  PMID:15898738
• Martemyanov, K. A., Yoo, P. J., Skiba, N. P., Arshavsky, V. Y. R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family Journal of Biological Chemistry  2005 280:5133-5136  DOI:10.1074/jbc.C400596200  PMID:15632198
• Keresztes, G., Martemyanov, K. A., Krispel, C. M., Mutai, H., Yoo, P. J., Maison, S. F., Burns, M. E., Arshavsky, V. Y., Heller, S. Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse Journal of Biological Chemistry  2004 279:1581-1584  DOI:10.1074/jbc.C300456200  PMID:14625292
• Nishiguchi, K. M., Sandberg, M. A., Kooijman, A. C., Martemyanov, K. A., Pott, J. W. R., Hagstrom, S. A., Arshavsky, V. Y., Berson, E. L., Dryja, T. P. Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation Nature  2004 427:75-78  DOI:10.1038/nature02170  PMID:14702087
• Martemyanov, K. A., Arshavsky, V. Y. Kinetic approaches to study the function of RGS9 isoforms Methods in Enzymology  2004 390:196-209  PMID:15488179
• Martemyanov, K. A., Lishko, P. V., Calero, N., Keresztes, G., Sokolov, M., Strissel, K. J., Leskov, I. B., Hopp, J. A., Kolesnikov, A. V., Chen, C. K., Lem, J., Heller, S., et al. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo Journal of Neuroscience  2003 23:10175-10181  PMID:14614075
• Martemyanov, K. A., Hopp, J. A., Arshavsky, V. Y. Specificity of G protein-RGS protein recognition is regulated by affinity adapters Neuron  2003 38:857-862  DOI:10.1016/s0896-6273(03)00320-9  PMID:12818172
• Martemyanov, K. A., Arshavsky, V. Y. Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity Journal of Biological Chemistry  2002 277:32843-32848  DOI:10.1074/jbc.M205170200  PMID:12093815
• Lishko, P. V., Martemyanov, K. A., Hopp, J. A., Arshavsky, V. Y. Specific binding of RGS9-G beta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity Journal of Biological Chemistry  2002 277:24376-24381  DOI:10.1074/jbc.M203237200  PMID:12006596
• Skiba, N. P., Martemyanov, K. A., Elfenbein, A., Hopp, J. A., Bohm, A., Simonds, W. F., Arshavsky, V. Y. Rgs9-g beta 5 substrate selectivity in photoreceptors - opposing effects of constituent domains yield high affinity of rgs interaction with the g protein-effector complex Journal of Biological Chemistry  2001 276:37365-37372  DOI:10.1074/jbc.M106431200  PMID:11495924
• Martemyanov, K. A., Liljas, A., Yarunin, A. S., Gudkov, A. T. Mutations in the G-domain of elongation factor G from thermus thermophilus affect both its interaction with GTP and fusidic acid Journal of Biological Chemistry  2001 276:28774-28778  DOI:10.1074/jbc.M102023200  PMID:11371559
• Martemyanov, K. A., Shirokov, V. A., Kurnasov, O. V., Gudkov, A. T., Spirin, A. S. Cell-free production of biologically active polypeptides: application to the synthesis of antibacterial peptide cecropin Protein Expression and Purification  2001 21:456-461  DOI:10.1006/prep.2001.1400  PMID:11281721
• Martemyanov, K. A., Gudkov, A. T. Domain III of elongation factor G from thermus thermophilus is essential for induction of GTP hydrolysis on the ribosome Journal of Biological Chemistry  2000 275:35820-35824  DOI:10.1074/jbc.M002656200  PMID:10940297
• Laurberg, M., Kristensen, O., Martemyanov, K., Gudkov, A. T., Nagaev, I., Hughes, D., Liljas, A. Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site Journal of Molecular Biology  2000 303:593-603  DOI:10.1006/jmbi.2000.4168  PMID:11054294
• Martemyanov, K. A., Liljas, A., Gudkov, A. T. Extremely thermostable elongation factor G from Aquifex aeolicus: Cloning, expression, purification, and characterization in a heterologous translation system Protein Expression and Purification  2000 18:257-261  DOI:10.1006/prep.1999.1178  PMID:10733877
• Martemyanov, K. A., Gudkov, A. T. Domain IV of elongation factor G from thermus thermophilus is strictly required for translocation FEBS Letters  1999 452:155-159  DOI:10.1016/s0014-5793(99)00635-3  PMID:10386581
• Martemyanov, K. A., Liljas, A., Gudkov, A. T. Increased functional activity of elongation factor G with G16V mutation in the GTP-binding domain Biochemistry-Moscow  1998 63:1216-1219  PMID:9864458
• Martemyanov, K. A., Yarunin, A. S., Liljas, A., Gudkov, A. T. An intact conformation at the tip of elongation factor G domain IV is functionally important FEBS Letters  1998 434:205-208  DOI:10.1016/s0014-5793(98)00982-x  PMID:9738479
• Martemyanov, K. A., Spirin, A. S., Gudkov, A. T. Direct expression of pcr products in a cell-free transcription/translation system: synthesis of antibacterial peptide cecropin FEBS Letters  1997 414:268-270  DOI:10.1016/s0014-5793(97)01011-9  PMID:9315699
• Martemyanov, K. A., Spirin, A. S., Gudkov, A. T. Synthesis, cloning and expression of genes for antibacterial peptides: Cecropin, magainin and bombinin Biotechnology Letters  1996 18:1357-1362  DOI:10.1007/bf00129335