recent publications
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academic article
- Stoveken, H. M., Zucca, S., Masuho, I., Grill, B., Martemyanov, K. A. The orphan receptor GPR139 signals via G(q/11)to oppose opioid effects Journal of Biological Chemistry 2020 295:10822-10830 DOI:10.1074/jbc.AC120.014770 PMID:32576659 PMCID:PMC7397111
- Anderson, A., Masuho, I., de Velasco, E. M. F., Nakano, A., Birnbaumer, L., Martemyanov, K. A., Wickman, K. GPCR-dependent biasing of GIRK channel signaling dynamics by RGS6 in mouse sinoatrial nodal cells Proceedings of the National Academy of Sciences of the United States of America 2020 117:14522-14531 DOI:10.1073/pnas.2001270117 PMID:32513692 PMCID:PMC7322085
- Masuho, I., Skamangas, N. K., Martemyanov, K. A. Live Cell Optical Assay for Precise Characterization of Receptors Coupling to Gα12 Basic & Clinical Pharmacology & Toxicology 2020 126:88-95 DOI:10.1111/bcpt.13228 PMID:30916867 PMCID:PMC6764917
- Xu, L., Bolch, S. N., Santiago, C. P., Dyka, F. M., Akil, O., Lobanova, E. S., Wang, Y., Martemyanov, K. A., Hauswirth, W. W., Smith, W. C., Handa, J. T., Blackshaw, S., et al. Clarin-1 expression in adult mouse and human retina highlights a role of Muller glia in Usher syndrome Journal of Pathology 2020 250:195-204 DOI:10.1002/path.5360 PMID:31625146 PMCID:PMC7003947
- Bartoszek, A., Von Moo, E., Binienda, A., Fabisiak, A., Krajewska, J. B., Mosinska, P., Niewinna, K., Tarasiuk, A., Martemyanov, K., Salaga, M., Fichna, J. Free Fatty Acid Receptors as new potential therapeutic target in inflammatory bowel diseases Pharmacological Research 2020 152 DOI:10.1016/j.phrs.2019.104604 PMID:31846762
- Masuho, I., Balaji, S., Muntean, B. S., Skamangas, N. K., Chavali, S., Tesmer, J. J. G., Babu, M. M., Martemyanov, K. A. A Global Map of G Protein Signaling Regulation by RGS Proteins Cell 2020 183:503-521 DOI:10.1016/j.cell.2020.08.052 PMID:33007266 PMCID:PMC7572916
- Cao, Y., Wang, Y. C., Dunn, H. A., Orlandi, C., Shultz, N., Kamasawa, N., Fitzpatrick, D., Li, W., Zeitz, C., Hauswirth, W., Martemyanov, K. A. Interplay between cell-adhesion molecules governs synaptic wiring of cone photoreceptors Proceedings of the National Academy of Sciences of the United States of America 2020 117:23914-23924 DOI:10.1073/pnas.2009940117 PMID:32879010 PMCID:PMC7519344
- Doyle, T. B., Muntean, B. S., Ejendal, K. F., Hayes, M. P., Soto-Velasquez, M., Martemyanov, K. A., Dessauer, C. W., Hu, C. D., Watts, V. J. Identification of novel adenylyl cyclase 5 (AC5) signaling networks in D1 and D2 medium spiny neurons using bimolecular fluorescence complementation screening Cells 2019 8 DOI:10.3390/cells8111468 PMID:31752385 PMCID:PMC6912275
- Muntean, B. S., Dao, M. T., Martemyanov, K. A. Allostatic changes in the cAMP system drive opioid-induced adaptation in striatal dopamine signaling Cell Reports 2019 29:946-960 DOI:10.1016/j.celrep.2019.09.034 PMID:31644915
- Dunn, H. A., Orlandi, C., Martemyanov, K. A. Beyond the ligand: extracellular and transcellular G protein-coupled receptor complexes in physiology and pharmacology Pharmacological Reviews 2019 71:503-519 DOI:10.1124/pr.119.018044 PMID:31515243 PMCID:PMC6742926
- Sutton, L. P., Muntean, B. S., Ostrovskaya, O., Zucca, S., Dao, M., Orlandi, C., Song, C., Xie, K., Martemyanov, K. A. NF1-cAMP signaling dissociates cell type-specific contributions of striatal medium spiny neurons to reward valuation and motor control PLoS Biology 2019 17 DOI:10.1371/journal.pbio.3000477 PMID:31600280 PMCID:PMC6805008
- Wang, D., Stoveken, H. M., Zucca, S., Dao, M., Orlandi, C., Song, C. H., Masuho, I., Johnston, C., Opperman, K. J., Giles, A. C., Gill, M. S., Lundquist, E. A., et al. Genetic behavioral screen identifies an orphan anti-opioid system Science 2019 365:1267-+ DOI:10.1126/science.aau2078 PMID:31416932
- Cirnaru, M. D., Melis, C., Fanutza, T., Naphade, S., Tshilenge, K. T., Muntean, B. S., Martemyanov, K. A., Plotkin, J. L., Ellerby, L. M., Ehrlich, M. E. Nuclear receptor Nr4a1 regulates striatal striosome development and dopamine D1 receptor signaling eNeuro 2019 6:Unsp eneuro.0305-19.2019 DOI:10.1523/eneuro.0305-19.2019 PMID:31541002 PMCID:PMC6787343
- Song, C., Orlandi, C., Sutton, L. P., Martemyanov, K. A. The signaling proteins GPR158 and RGS7 modulate excitability of L2/3 pyramidal neurons and control A-type potassium channel in the prelimbic cortex Journal of Biological Chemistry 2019 294:13145-13157 DOI:10.1074/jbc.RA119.007533 PMID:31311860 PMCID:PMC6721952
- Xu, Z. X., Tan, J. W., Xu, H., Hill, C. J., Ostrovskaya, O., Martemyanov, K. A., Xu, B. Caspase-2 promotes AMPA receptor internalization and cognitive flexibility via mTORC2-AKT-GSK3β signaling Nature Communications 2019 10 DOI:10.1038/s41467-019-11575-1 PMID:31399584 PMCID:PMC6689033
- Itakura, T., Webster, A., Chintala, S. K., Wang, Y., Gonzalez Jr., J. M., Tan, J. C., Vranka, J. A., Acott, T., Craft, C. M., Saber, M. E. S., Jeong, S., Stamer, W. D., et al. GPR158 in the visual system: homeostatic role in regulation of intraocular pressure Journal of Ocular Pharmacology and Therapeutics 2019 35:203-215 DOI:10.1089/jop.2018.0135 PMID:30855200
- Orlandi, C., Sutton, L. P., Muntean, B. S., Song, C., Martemyanov, K. A. Homeostatic cAMP regulation by the RGS7 complex controls depression-related behaviors Neuropsychopharmacology 2019 44:642-653 DOI:10.1038/s41386-018-0238-y PMID:30546127 PMCID:PMC6333837
- Patil, D. N., Rangarajan, E. S., Novick, S. J., Pascal, B. D., Kojetin, D. J., Griffin, P. R., Izard, T., Martemyanov, K. A. Structural organization of a major neuronal G protein regulator, the RGS7-Gβ5-R7BP complex Elife 2018 7 DOI:10.7554/eLife.42150 PMID:30540250 PMCID:PMC6310461
- Ostrovskaya, O. I., Orlandi, C., Fajardo-Serrano, A., Young, S. M., Lujan, R., Martemyanov, K. A. Inhibitory signaling to ion channels in hippocampal neurons is differentially regulated by alternative macromolecular complexes of RGS7 Journal of Neuroscience 2018 38:10002-10015 DOI:10.1523/jneurosci.1378-18.2018 PMID:30315127 PMCID:PMC6234300
- Condomitti, G., Wierda, K. D., Schroeder, A., Rubio, S. E., Vennekens, K. M., Orlandi, C., Martemyanov, K. A., Gounko, N. V., Savas, J. N., de Wit, J. An input-specific orphan receptor GPR158-HSPG interaction organizes hippocampal mossy fiber-CA3 synapses Neuron 2018 100:201-215 DOI:10.1016/j.neuron.2018.08.038 PMID:30290982
- Orlandi, C., Omori, Y., Wang, Y., Cao, Y., Ueno, A., Roux, M. J., Condomitti, G., de Wit, J., Kanagawa, M., Furukawa, T., Martemyanov, K. A. Transsynaptic binding of orphan receptor GPR179 to dystroglycan-pikachurin complex is essential for the synaptic organization of photoreceptors Cell Reports 2018 25:130-145 DOI:10.1016/j.celrep.2018.08.068 PMID:30282023
- Song, C. H., Anderson, G. R., Sutton, L. P., Dao, M., Martemyanov, K. A. Selective role of RGS9-2 in regulating retrograde synaptic signaling of indirect pathway medium spiny neurons in dorsal striatum Journal of Neuroscience 2018 38:7120-7131 DOI:10.1523/jneurosci.0493-18.2018 PMID:30006367 PMCID:PMC6083461
- Masuho, I., Chavali, S., Muntean, B. S., Skamangas, N. K., Simonyan, K., Patil, D. N., Kramer, G. M., Ozelius, L., Babu, M. M., Martemyanov, K. A. Molecular deconvolution platform to establish disease mechanisms by surveying GPCR signaling Cell Reports 2018 24:557-568 DOI:10.1016/j.celrep.2018.06.080 PMID:30021154 PMCID:PMC6077248
- Gulati, S., Jin, H., Masuho, I., Orban, T., Cai, Y., Pardon, E., Martemyanov, K. A., Kiser, P. D., Stewart, P. L., Ford, C. P., Steyaert, J., Palczewski, K. Targeting G protein-coupled receptor signaling at the G protein level with a selective nanobody inhibitor Nature Communications 2018 9 DOI:10.1038/s41467-018-04432-0 PMID:29777099 PMCID:PMC5959942
- Martemyanov, K. A., Garcia-Marcos, M. Making useful gadgets with miniaturized G proteins Journal of Biological Chemistry 2018 293:7474-7475 DOI:10.1074/jbc.H118.002879 PMID:29752421 PMCID:PMC5949992
- Dunn, H. A., Patil, D. N., Cao, Y., Orlandi, C., Martemyanov, K. A. Synaptic adhesion protein ELFN1 is a selective allosteric modulator of group III metabotropic glutamate receptors in trans Proceedings of the National Academy of Sciences of the United States of America 2018 115:5022-5027 DOI:10.1073/pnas.1722498115 PMID:29686062 PMCID:PMC5948991
- Marcott, P. F., Gong, S., Donthamsetti, P., Grinnell, S. G., Nelson, M. N., Newman, A. H., Birnbaumer, L., Martemyanov, K. A., Javitch, J. A., Ford, C. P. Regional heterogeneity of D2-receptor signaling in the dorsal striatum and nucleus accumbens Neuron 2018 98:575-587 DOI:10.1016/j.neuron.2018.03.038 PMID:29656874
- Kulkarni, K., Xie, X., de Velasco, E. M. F., Anderson, A., Martemyanov, K. A., Wickman, K., Tolkacheva, E. G. The influences of the M2R-GIRK4-RGS6 dependent parasympathetic pathway on electrophysiological properties of the mouse heart PLoS One 2018 13 DOI:10.1371/journal.pone.0193798 PMID:29668674 PMCID:PMC5905881
- Muntean, B. S., Patil, D. N., Madoux, F., Fossetta, J., Scampavia, L., Spicer, T. P., Martemyanov, K. A. A high-throughput time-resolved fluorescence energy transfer assay to screen for modulators of RGS7/Gβ5/R7BP complex Assay and Drug Development Technologies 2018 16:150-161 DOI:10.1089/adt.2017.839 PMID:29658790 PMCID:PMC5906730
- Sarria, I., Cao, Y., Wang, Y., Ingram, N. T., Orlandi, C., Kamasawa, N., Kolesnikov, A. V., Pahlberg, J., Kefalov, V. J., Sampath, A. P., Martemyanov, K. A. LRIT1 modulates adaptive changes in synaptic communication of cone photoreceptors Cell Reports 2018 22:3562-3573 DOI:10.1016/j.celrep.2018.03.008 PMID:29590623 PMCID:PMC5902029
- Sutton, L. P., Orlandi, C., Song, C., Oh, W. C., Muntean, B. S., Xie, K., Filippini, A., Xie, X., Satterfield, R., Yaeger, J. D. W., Renner, K. J., Young Jr., S. M., et al. Orphan receptor GPR158 controls stress-induced depression Elife 2018 7 DOI:10.7554/eLife.33273 PMID:29419376 PMCID:PMC5823542
- Anderson, A., Kulkarni, K., de Velasco, E. M. F., Carlblom, N., Xia, Z., Nakano, A., Martemyanov, K. A., Tolkacheva, E. G., Wickman, K. Expression and relevance of the G protein-gated K+ channel in the mouse ventricle Scientific Reports 2018 8 DOI:10.1038/s41598-018-19719-x PMID:29352184 PMCID:PMC5775354
- Qutob, N., Masuho, I., Alon, M., Emmanuel, R., Cohen, I., Di Pizio, A., Madore, J., Elkahloun, A., Ziv, T., Levy, R., Gartner, J. J., Hill, V. K., et al. RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells Scientific Reports 2018 8 DOI:10.1038/s41598-017-18851-4 PMID:29330521 PMCID:PMC5766496
- Hauser, A. S., Chavali, S., Masuho, I., Jahn, L. J., Martemyanov, K. A., Gloriam, D. E., Babu, M. M. Pharmacogenomics of GPCR drug targets Cell 2018 172:41-54 DOI:10.1016/j.cell.2017.11.033 PMID:29249361 PMCID:PMC5766829
- Muntean, B. S., Zucca, S., MacMullen, C. M., Dao, M. T., Johnston, C., Iwamoto, H., Blakely, R. D., Davis, R. L., Martemyanov, K. A. Interrogating the spatiotemporal landscape of neuromodulatory GPCR signaling by real-time imaging of cAMP in intact neurons and circuits Cell Reports 2018 22:255-268 DOI:10.1016/j.celrep.2017.12.022 PMID:29298426 PMCID:PMC5761078
- Himmelreich, S., Masuho, I., Berry, J. A., MacMullen, C., Skamangas, N. K., Martemyanov, K. A., Davis, R. L. Dopamine receptor DAMB signals via Gq to mediate forgetting in Drosophila Cell Reports 2017 21:2074-2081 DOI:10.1016/j.celrep.2017.10.108 PMID:29166600
- Carmon, K. S., Gong, X., Yi, J., Wu, L., Thomas, A., Moore, C. M., Masuho, I., Timson, D. J., Martemyanov, K. A., Liu, Q. J. Y. LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway Journal of Biological Chemistry 2017 292:14989-15001 DOI:10.1074/jbc.M117.786798 PMID:28739799 PMCID:PMC5592675
- Wang, Y., Fehlhaber, K. E., Sarria, I., Cao, Y., Ingram, N. T., Guerrero-Given, D., Throesch, B., Baldwin, K., Kamasawa, N., Ohtsuka, T., Sampath, A. P., Martemyanov, K. A. The auxiliary calcium channel subunit α2δ4 is required for axonal elaboration, synaptic transmission, and wiring of rod photoreceptors Neuron 2017 93:1359-1374 DOI:10.1016/j.neuron.2017.02.021 PMID:28262416 PMCID:PMC5364038
- Lohmann, K., Masuho, I., Patil, D. N., Baumann, H., Hebert, E., Steinrucke, S., Trujillano, D., Skamangas, N. K., Dobricic, V., Huning, I., Gillessen-Kaesbach, G., Westenberger, A., et al. Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans Human Molecular Genetics 2017 26:1078-1086 DOI:10.1093/hmg/ddx018 PMID:28087732
- Neuille, M., Cao, Y., Caplette, R., Guerrero-Given, D., Thomas, C., Kamasawa, N., Sahel, J. A., Hamel, C. P., Audo, I., Picaud, S., Martemyanov, K. A., Zeitz, C. LRIT3 differentially affects connectivity and synaptic transmission of cones to ON- and OFF-bipolar Cells Investigative Ophthalmology & Visual Science 2017 58:1768-1778 DOI:10.1167/iovs.16-20745 PMID:28334377 PMCID:PMC5374884
- Martemyanov, K. A., Sampath, A. P. The transduction cascade in retinal ON-bipolar cells: signal processing and disease Annual Review of Vision Science 2017 3:25-51 DOI:10.1146/annurev-vision-102016-061338 PMID:28715957
- Aguado, C., Orlandi, C., Fajardo-Serrano, A., Gil-Minguez, M., Martemyanov, K. A., Lujan, R. Cellular and subcellular localization of the RGS7/Gβ5/R7BP complex in the cerebellar cortex Frontiers in Neuroanatomy 2016 10 DOI:10.3389/fnana.2016.00114 PMID:27965545 PMCID:PMC5127842
- Xie, K., Colgan, L. A., Dao, M. T., Muntean, B. S., Sutton, L. P., Orlandi, C., Boye, S. L., Boye, S. E., Shih, C. C., Li, Y., Xu, B., Smith, R. G., et al. NF1 is a direct G protein effector essential for opioid signaling to Ras in the striatum Current Biology 2016 26:2992-3003 DOI:10.1016/j.cub.2016.09.010 PMID:27773571 PMCID:PMC5121064
- Victoria, N. C., Marron Fernandez de Velasco, E., Ostrovskaya, O., Metzger, S., Xia, Z., Kotecki, L., Benneyworth, M. A., Zink, A. N., Martemyanov, K. A., Wickman, K. G protein-gated K+ channel ablation in forebrain pyramidal neurons selectively impairs fear learning Biological Psychiatry 2016 80:796-806 DOI:10.1016/j.biopsych.2015.10.004 PMID:26612516 PMCID:PMC4862939
- Sutton, L. P., Ostrovskaya, O., Dao, M., Xie, K., Orlandi, C., Smith, R., Wee, S., Martemyanov, K. A. Regulator of G-protein signaling 7 regulates reward behavior by controlling opioid signaling in the striatum Biological Psychiatry 2016 80:235-245 DOI:10.1016/j.biopsych.2015.07.026 PMID:26364547 PMCID:PMC4753143
- Chen, Y., Palczewska, G., Masuho, I., Gao, S., Jin, H., Dong, Z., Gieser, L., Brooks, M. J., Kiser, P. D., Kern, T. S., Martemyanov, K. A., Swaroop, A., et al. Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration Science Signaling 2016 9 DOI:10.1126/scisignal.aag0245 PMID:27460988 PMCID:PMC4972460
- Tayou, J., Wang, Q., Jang, G. F., Pronin, A. N., Orlandi, C., Martemyanov, K. A., Crabb, J. W., Slepak, V. Z. Regulator of G protein signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by Gαo and R7-binding protein Journal of Biological Chemistry 2016 291:9133-9147 DOI:10.1074/jbc.M115.694075 PMID:26895961 PMCID:PMC4861480
- Salaga, M., Storr, M., Martemyanov, K. A., Fichna, J. RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives Bioessays 2016 38:344-354 DOI:10.1002/bies.201500118 PMID:26817719 PMCID:PMC4916644
- Dos Santos, C. O., Masuho, I., da Silva-Júnior, F. P., Barbosa, E. R., Silva, S. M. C. A., Borges, V., Ferraz, H. B., Rocha, M. S. G., Limongi, J. C. P., Martemyanov, K. A., de Carvalho Aguiar, P. Screening of GNAL variants in Brazilian patients with isolated dystonia reveals a novel mutation with partial loss of function Journal of Neurology 2016 263:665-668 DOI:10.1007/s00415-016-8026-2 PMID:26810727 PMCID:PMC4828253
- Muntean, B. S., Martemyanov, K. A. Association with the plasma membrane is sufficient for potentiating catalytic activity of regulators of G protein signaling (RGS) proteins of the R7 subfamily Journal of Biological Chemistry 2016 291:7195-7204 DOI:10.1074/jbc.M115.713446 PMID:26811338 PMCID:PMC4807299
- Xu, Y., Orlandi, C., Cao, Y., Yang, S., Choi, C. I., Pagadala, V., Birnbaumer, L., Martemyanov, K. A., Vardi, N. The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein G(o) Scientific Reports 2016 6 DOI:10.1038/srep20940 PMID:26883481 PMCID:PMC4756708
- Shamseldin, H. E., Masuho, I., Alenizi, A., Alyamani, S., Patil, D. N., Ibrahim, N., Martemyanov, K. A., Alkuraya, F. S. GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition Genome Biology 2016 17 DOI:10.1186/s13059-016-1061-6 PMID:27677260 PMCID:PMC5037613
- Sarria, I., Orlandi, C., McCall, M. A., Gregg, R. G., Martemyanov, K. A. Intermolecular interaction between anchoring subunits specify subcellular targeting and function of RGS proteins in retina ON-bipolar neurons Journal of Neuroscience 2016 36:2915-2925 DOI:10.1523/jneurosci.3833-15.2016 PMID:26961947 PMCID:PMC4783495
- Masuho, I., Ostrovskaya, O., Kramer, G. M., Jones, C. D., Xie, K., Martemyanov, K. A. Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors Science Signaling 2015 8:ra123 DOI:10.1126/scisignal.aab4068 PMID:26628681 PMCID:PMC4886239
- Xie, K., Masuho, I., Shih, C. C., Cao, Y., Sasaki, K., Lai, C. W. J., Han, P. L., Ueda, H., Dessauer, C. W., Ehrlich, M. E., Xu, B., Willardson, B. M., et al. Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling Elife 2015 4 DOI:10.7554/eLife.10451 PMID:26613416 PMCID:PMC4728126
- Cao, Y., Sarria, I., Fehlhaber, K. E., Kamasawa, N., Orlandi, C., James, K. N., Hazen, J. L., Gardner, M. R., Farzan, M., Lee, A., Baker, S., Baldwin, K., et al. Mechanism for selective synaptic wiring of rod photoreceptors into the retinal circuitry and its role in vision Neuron 2015 87:1248-1260 DOI:10.1016/j.neuron.2015.09.002 PMID:26402607 PMCID:PMC4583715
- Neuille, M., Morgans, C. W., Cao, Y., Orhan, E., Michiels, C., Sahel, J. A., Audo, I., Duvoisin, R. M., Martemyanov, K. A., Zeitz, C. LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation European Journal of Neuroscience 2015 42:1966-1975 DOI:10.1111/ejn.12959 PMID:25997951 PMCID:PMC4733627
- Orlandi, C., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Martemyanov, K. A. Orphan receptor GPR158 is an allosteric modulator of RGS7 catalytic activity with an essential role in dictating its expression and localization in the brain Journal of Biological Chemistry 2015 290:13622-13639 DOI:10.1074/jbc.M115.645374 PMID:25792749 PMCID:PMC4447942
- Martemyanov, K. A. G protein signaling in the retina and beyond: the Cogan lecture Investigative Ophthalmology & Visual Science 2014 55:8201-8207 DOI:10.1167/iovs.14-15928 PMID:25511392 PMCID:PMC4541486
- Ray, T. A., Heath, K. M., Hasan, N., Noel, J. M., Samuels, I. S., Martemyanov, K. A., Peachey, N. S., McCall, M. A., Gregg, R. G. GPR179 is required for high sensitivity of the mGluR6 signaling cascade in depolarizing bipolar cells Journal of Neuroscience 2014 34:6334-6343 DOI:10.1523/jneurosci.4044-13.2014 PMID:24790204 PMCID:PMC4004817
- Ostrovskaya, O., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Wickman, K., Martemyanov, K. A. RGS7/G beta 5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABA(B)R-GIRK signaling Elife 2014 3:e02053 DOI:10.7554/eLife.02053 PMID:24755289 PMCID:PMC3988575
- Kumar, K. R., Lohmann, K., Masuho, I., Miyamoto, R., Ferbert, A., Lohnau, T., Kasten, M., Hagenah, J., Bruggemann, N., Graf, J., Munchau, A., Kostic, V. S., et al. Mutations in GNAL: a novel cause of craniocervical dystonia JAMA Neurology 2014 71:490-494 DOI:10.1001/jamaneurol.2013.4677 PMID:24535567 PMCID:PMC4237020
- Wydeven, N., Posokhova, E., Xia, Z. L., Martemyanov, K. A., Wickman, K. RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate Journal of Biological Chemistry 2014 289:2440-2449 DOI:10.1074/jbc.M113.520742 PMID:24318880 PMCID:PMC3900986
- Fajardo-Serrano, A., Wydeven, N., Young, D., Watanabe, M., Shigemoto, R., Martemyanov, K. A., Wickman, K., Lujan, R. Association of Rgs7/Gβ5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons Hippocampus 2013 23:1231-1245 DOI:10.1002/hipo.22161 PMID:23804514 PMCID:PMC4060866
- Posokhova, E., Ng, D., Opel, A., Masuho, I., Tinker, A., Biesecker, L. G., Wickman, K., Martemyanov, K. A. Essential role of the m(2)R-RGS6-I-KACh pathway in controlling intrinsic heart rate variability PLoS One 2013 8:e76973 DOI:10.1371/journal.pone.0076973 PMID:24204714 PMCID:PMC3812209
- Orlandi, C., Cao, Y., Martemyanov, K. A. Orphan receptor GPR179 forms macromolecular complexes with components of metabotropic signaling cascade in retina ON-bipolar neurons Investigative Ophthalmology and Visual Science 2013 54:7153-7161 DOI:10.1167/iovs.13-12907 PMID:24114537 PMCID:PMC3813323
- Masuho, I., Xie, K., Martemyanov, K. A. Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells Journal of Biological Chemistry 2013 288:25129-25142 DOI:10.1074/jbc.M113.462283 PMID:23857581 PMCID:PMC3757177
- Fuchs, T., Saunders-Pullman, R., Masuho, I., Luciano, M. S., Raymond, D., Factor, S., Lang, A. E., Liang, T. W., Trosch, R. M., White, S., Ainehsazan, E., Herve, D., et al. Mutations in GNAL cause primary torsion dystonia Nature Genetics 2013 45:88-92 DOI:10.1038/ng.2496 PMID:23222958 PMCID:PMC3530620
- Xie, K. Q., Masuho, I., Brand, C., Dessauer, C. W., Martemyanov, K. A. The complex of G protein regulator RGS9-2 and G beta(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum Science Signaling 2012 5:ra63 DOI:10.1126/scisignal.2002922 PMID:22932702 PMCID:PMC3580943
- Orlandi, C., Posokhova, E., Masuho, I., Ray, T. A., Hasan, N., Gregg, R. G., Martemyanov, K. A. GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes Journal of Cell Biology 2012 197:711-719 DOI:10.1083/jcb.201202123 PMID:22689652 PMCID:PMC3373406
- Cao, Y., Pahlberg, J., Sarria, I., Kamasawa, N., Sampath, A. P., Martemyanov, K. A. Regulators of g protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons Proceedings of the National Academy of Sciences of the United States of America 2012 109:7905-7910 DOI:10.1073/pnas.1202332109 PMID:22547806 PMCID:PMC3356620
- Terzi, D., Cao, Y., Agrimaki, I., Martemyanov, K. A., Zachariou, V. R7BP modulates opiate analgesia and tolerance but not withdrawal Neuropsychopharmacology 2012 37:1005-1012 DOI:10.1038/npp.2011.284 PMID:22089315 PMCID:PMC3280654
- Xie, K. Q., Ge, S. C., Collins, V. E., Haynes, C. L., Renner, K. J., Meisel, R. L., Lujan, R., Martemyanov, K. A. G beta 5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems Psychopharmacology 2012 219:823-834 DOI:10.1007/s00213-011-2409-y PMID:21766168 PMCID:PMC3260372
- Gopalakrishna, K. N., Doddapuneni, K., Boyd, K. K., Masuho, I., Martemyanov, K. A., Artemyev, N. O. Interaction of transducin with uncoordinated 119 protein (UNC119) implications for the model of transducin trafficking in rod photoreceptors Journal of Biological Chemistry 2011 286:28954-28962 DOI:10.1074/jbc.M111.268821 PMID:21712387 PMCID:PMC3190703
- Cao, Y., Posokhova, E., Martemyanov, K. A. TRPM1 forms complexes with nyctalopin in vivo and accumulates in postsynaptic compartment of ON-bipolar neurons in mGluR6-dependent manner Journal of Neuroscience 2011 31:11521-11526 DOI:10.1523/jneurosci.1682-11.2011 PMID:21832182 PMCID:PMC3164511
- Xie, K. Q., Martemyanov, K. A. Control of striatal signaling by G protein regulators Frontiers in Neuroanatomy 2011 5:49 DOI:10.3389/fnana.2011.00049 PMID:21852966 PMCID:PMC3151604
- Masuho, I., Wakasugi-Masuho, H., Posokhova, E. N., Patton, J. R., Martemyanov, K. A. Type 5 G protein beta subunit (G beta 5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors Journal of Biological Chemistry 2011 286:21806-21813 DOI:10.1074/jbc.M111.241513 PMID:21511947 PMCID:PMC3122235
- Posokhova, E., Song, H., Belcastro, M., Higgins, L., Bigley, L. R., Michaud, N. A., Martemyanov, K. A., Sokolov, M. Disruption of the chaperonin containing TCP-1 function affects protein networks essential for rod outer segment morphogenesis and survival Molecular & Cellular Proteomics 2011 10:M110.000570 DOI:10.1074/mcp.M110.000570 PMID:20852191 PMCID:PMC3013443
- Porter, M. Y., Xie, K. Q., Pozharski, E., Koelle, M. R., Martemyanov, K. A. A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins Journal of Biological Chemistry 2010 285:41100-41112 DOI:10.1074/jbc.M110.163600 PMID:20959458 PMCID:PMC3003408
- Posokhova, E., Wydeven, N., Allen, K. L., Wickman, K., Martemyanov, K. A. RGS6/G beta 5 complex accelerates IKaCh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate Circulation Research 2010 107:1350-1354 DOI:10.1161/circresaha.110.224212 PMID:20884879 PMCID:PMC3014848
- Cao, Y., Kolesnikov, A. V., Masuho, I., Kefalov, V. J., Martemyanov, K. A. Membrane anchoring subunits specify selective regulation of RGS9/Gbeta5 GAP complex in photoreceptor neurons Journal of Neuroscience 2010 30:13784-13793 DOI:10.1523/jneurosci.1191-10.2010 PMID:20943919 PMCID:PMC2975674
- Xie, K. Q., Allen, K. L., Kourrich, S., Colon-Saez, J., Thomas, M. J., Wickman, K., Martemyanov, K. A. G beta 5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling Nature Neuroscience 2010 13:661-663 DOI:10.1038/nn.2549 PMID:20453851 PMCID:PMC2876203
- Panicker, L. M., Zhang, J. H., Posokhova, E., Gastinger, M. J., Martemyanov, K. A., Simonds, W. F. Nuclear localization of the G protein beta 5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein Journal of Neurochemistry 2010 113:1101-1112 DOI:10.1111/j.1471-4159.2010.06616.x PMID:20100282 PMCID:PMC2890294
- Posokhova, E., Uversky, V., Martemyanov, K. A. Proteomic identification of Hsc70 as a mediator of RGS9-2 degradation by in vivo interactome analysis Journal of Proteome Research 2010 9:1510-1521 DOI:10.1021/pr901022m PMID:20095651 PMCID:PMC2890236
- Anderson, G. R., Cao, Y., Davidson, S., Truong, H. V., Pravetoni, M., Thomas, M. J., Wickman, K., Giesler, G. J., Martemyanov, K. A. R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine Neuropsychopharmacology 2010 35:1040-1050 DOI:10.1038/npp.2009.212 PMID:20043004 PMCID:PMC2887292
- Roloff, A. M., Anderson, G. R., Martemyanov, K. A., Thayer, S. A. Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity Journal of Neuroscience 2010 30:3072-3081 DOI:10.1523/jneurosci.4603-09.2010 PMID:20181604 PMCID:PMC2843151
- Masuho, I., Celver, J., Kovoor, A., Martemyanov, K. A. Membrane anchor GTPase-accelerating protein activity of RGS11.G beta(5) complex and accelerates inactivation of the mGluR6-G(o) signaling Journal of Biological Chemistry 2010 285:4781-4787 DOI:10.1074/jbc.M109.058511 PMID:20007977 PMCID:PMC2836083
- Cao, Y., Masuho, I., Okawa, H., Xie, K. Q., Asami, J., Kammermeier, P. J., Maddox, D. M., Furukawa, T., Inoue, T., Sampath, A. P., Martemyanov, K. A. Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons Journal of Neuroscience 2009 29:9301-9313 DOI:10.1523/jneurosci.1367-09.2009 PMID:19625520 PMCID:PMC2731308
- Anderson, G. R., Posokhova, E., Martemyanov, K. A. The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling Cell Biochemistry and Biophysics 2009 54:33-46 DOI:10.1007/s12013-009-9052-9 PMID:19521673 PMCID:PMC2827338
- Anderson, G. R., Lujan, R., Martemyanov, K. A. Changes in striatal signaling induce remodeling of RGS complexes containing G beta 5 and R7BP subunits Molecular and Cellular Biology 2009 29:3033-3044 DOI:10.1128/mcb.01449-08 PMID:19332565 PMCID:PMC2682020
- Martemyanov, K. A., Krispel, C. M., Lishko, P. V., Burns, M. E., Arshavsky, V. Y. Functional comparison of RGS9 splice isoforms in a living cell Proceedings of the National Academy of Sciences of the United States of America 2008 105:20988-20993 DOI:10.1073/pnas.0808941106 PMID:19098104 PMCID:PMC2634932
- Kim, H. J., Martemyanov, K. A., Thayer, S. A. Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death Journal of Neuroscience 2008 28:12604-12613 DOI:10.1523/jneurosci.2958-08.2008 PMID:19036954 PMCID:PMC2678679
- Cao, Y., Song, H. M., Okawa, H., Sampath, A. P., Sokolov, M., Martemyanov, K. A. Targeting of RGS7/G beta 5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP Journal of Neuroscience 2008 28:10443-10449 DOI:10.1523/jneurosci.3282-08.2008 PMID:18842904 PMCID:PMC2587022
- Anderson, G. R., Lujan, R., Semenov, A., Pravetoni, M., Posokhova, E. N., Song, J. H., Uversky, V., Chen, C. K., Wickman, K., Martemyanov, K. A. Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases Journal of Neuroscience 2007 27:14117-14127 DOI:10.1523/jneurosci.3884-07.2007 PMID:18094251
- Song, J. H., Song, H., Wensel, T. G., Sokolov, M., Martemyanov, K. A. Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina Molecular and Cellular Neuroscience 2007 35:311-319 DOI:10.1016/j.mcn.2007.03.006 PMID:17442586
- Anderson, G. R., Semenov, A., Song, J. H., Martemyanov, K. A. The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2 Journal of Biological Chemistry 2007 282:4772-4781 DOI:10.1074/jbc.M610518200 PMID:17158100
- Baker, S. A., Martemyanov, K. A., Shavkunov, A. S., Arshavsky, V. Y. Kinetic mechanism of RGS9-1 potentiation by R9AP Biochemistry 2006 45:10690-10697 DOI:10.1021/bi060376a PMID:16939221
- Krispel, C. M., Chen, D., Melling, N., Chen, Y. J., Martemyanov, K. A., Quillinan, N., Arshavsky, V. Y., Wensel, T. G., Chen, C. K., Burns, M. E. RGS expression rate-limits recovery of rod photoresponses Neuron 2006 51:409-416 DOI:10.1016/j.neuron.2006.07.010 PMID:16908407
- Song, J. H., Waataja, J. J., Martemyanov, K. A. Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP Journal of Biological Chemistry 2006 281:15361-15369 DOI:10.1074/jbc.M600749200 PMID:16574655
- Grant, J. E., Guo, L. W., Vestling, M. M., Martemyanov, K. A., Arshavsky, V. Y., Ruoho, A. E. The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit Journal of Biological Chemistry 2006 281:6194-6202 DOI:10.1074/jbc.M509511200 PMID:16407279
- Guo, L. W., Hajipour, A. R., Gavala, M. L., Arbabian, M., Martemyanov, K. A., Arshavsky, V. Y., Ruoho, A. E. Sulfhydryl-reactive, cleavable, and radioiodinatable benzophenone photoprobes for study of protein-protein interaction Bioconjugate Chemistry 2005 16:685-693 DOI:10.1021/bc050016k PMID:15898738
- Martemyanov, K. A., Yoo, P. J., Skiba, N. P., Arshavsky, V. Y. R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family Journal of Biological Chemistry 2005 280:5133-5136 DOI:10.1074/jbc.C400596200 PMID:15632198
- Keresztes, G., Martemyanov, K. A., Krispel, C. M., Mutai, H., Yoo, P. J., Maison, S. F., Burns, M. E., Arshavsky, V. Y., Heller, S. Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse Journal of Biological Chemistry 2004 279:1581-1584 DOI:10.1074/jbc.C300456200 PMID:14625292
- Nishiguchi, K. M., Sandberg, M. A., Kooijman, A. C., Martemyanov, K. A., Pott, J. W. R., Hagstrom, S. A., Arshavsky, V. Y., Berson, E. L., Dryja, T. P. Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation Nature 2004 427:75-78 DOI:10.1038/nature02170 PMID:14702087
- Martemyanov, K. A., Arshavsky, V. Y. Kinetic approaches to study the function of RGS9 isoforms Methods in Enzymology 2004 390:196-209 PMID:15488179
- Martemyanov, K. A., Lishko, P. V., Calero, N., Keresztes, G., Sokolov, M., Strissel, K. J., Leskov, I. B., Hopp, J. A., Kolesnikov, A. V., Chen, C. K., Lem, J., Heller, S., et al. The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo Journal of Neuroscience 2003 23:10175-10181 PMID:14614075
- Martemyanov, K. A., Hopp, J. A., Arshavsky, V. Y. Specificity of G protein-RGS protein recognition is regulated by affinity adapters Neuron 2003 38:857-862 DOI:10.1016/s0896-6273(03)00320-9 PMID:12818172
- Martemyanov, K. A., Arshavsky, V. Y. Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity Journal of Biological Chemistry 2002 277:32843-32848 DOI:10.1074/jbc.M205170200 PMID:12093815
- Lishko, P. V., Martemyanov, K. A., Hopp, J. A., Arshavsky, V. Y. Specific binding of RGS9-G beta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity Journal of Biological Chemistry 2002 277:24376-24381 DOI:10.1074/jbc.M203237200 PMID:12006596
- Skiba, N. P., Martemyanov, K. A., Elfenbein, A., Hopp, J. A., Bohm, A., Simonds, W. F., Arshavsky, V. Y. Rgs9-g beta 5 substrate selectivity in photoreceptors - opposing effects of constituent domains yield high affinity of rgs interaction with the g protein-effector complex Journal of Biological Chemistry 2001 276:37365-37372 DOI:10.1074/jbc.M106431200 PMID:11495924
- Martemyanov, K. A., Liljas, A., Yarunin, A. S., Gudkov, A. T. Mutations in the G-domain of elongation factor G from thermus thermophilus affect both its interaction with GTP and fusidic acid Journal of Biological Chemistry 2001 276:28774-28778 DOI:10.1074/jbc.M102023200 PMID:11371559
- Martemyanov, K. A., Shirokov, V. A., Kurnasov, O. V., Gudkov, A. T., Spirin, A. S. Cell-free production of biologically active polypeptides: application to the synthesis of antibacterial peptide cecropin Protein Expression and Purification 2001 21:456-461 DOI:10.1006/prep.2001.1400 PMID:11281721
- Martemyanov, K. A., Gudkov, A. T. Domain III of elongation factor G from thermus thermophilus is essential for induction of GTP hydrolysis on the ribosome Journal of Biological Chemistry 2000 275:35820-35824 DOI:10.1074/jbc.M002656200 PMID:10940297
- Laurberg, M., Kristensen, O., Martemyanov, K., Gudkov, A. T., Nagaev, I., Hughes, D., Liljas, A. Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site Journal of Molecular Biology 2000 303:593-603 DOI:10.1006/jmbi.2000.4168 PMID:11054294
- Martemyanov, K. A., Liljas, A., Gudkov, A. T. Extremely thermostable elongation factor G from Aquifex aeolicus: Cloning, expression, purification, and characterization in a heterologous translation system Protein Expression and Purification 2000 18:257-261 DOI:10.1006/prep.1999.1178 PMID:10733877
- Martemyanov, K. A., Gudkov, A. T. Domain IV of elongation factor G from thermus thermophilus is strictly required for translocation FEBS Letters 1999 452:155-159 DOI:10.1016/s0014-5793(99)00635-3 PMID:10386581
- Martemyanov, K. A., Liljas, A., Gudkov, A. T. Increased functional activity of elongation factor G with G16V mutation in the GTP-binding domain Biochemistry-Moscow 1998 63:1216-1219 PMID:9864458
- Martemyanov, K. A., Yarunin, A. S., Liljas, A., Gudkov, A. T. An intact conformation at the tip of elongation factor G domain IV is functionally important FEBS Letters 1998 434:205-208 DOI:10.1016/s0014-5793(98)00982-x PMID:9738479
- Martemyanov, K. A., Spirin, A. S., Gudkov, A. T. Direct expression of pcr products in a cell-free transcription/translation system: synthesis of antibacterial peptide cecropin FEBS Letters 1997 414:268-270 DOI:10.1016/s0014-5793(97)01011-9 PMID:9315699
- Martemyanov, K. A., Spirin, A. S., Gudkov, A. T. Synthesis, cloning and expression of genes for antibacterial peptides: Cecropin, magainin and bombinin Biotechnology Letters 1996 18:1357-1362 DOI:10.1007/bf00129335