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Macmillan, Karen Smith
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Macmillan, Karen Smith

Graduate Student
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Positions

  • 2013 - 2017 Research Scientist, The University of Texas Southwestern Medical Center
  • 2011 - 2012 Senior Chemist, Reata Pharmaceuticals
  • 2011 Instructor, The University of Texas Southwestern Medical Center
  • 2009 - 2011 Assistant Instructor, The University of Texas Southwestern Medical Center

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  • Doctoral Dissertation
  • Publications
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Publications

recent publications
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  • academic article

    • Brockway, A. J., Volkov, O. A., Cosner, C. C., MacMillan, K. S., Wring, S. A., Richardson, T. E., Peel, M., Phillips, M. A., De Brabander, J. K. Synthesis and evaluation of analogs of 5 '-(((Z)-4-amino-2-butenyl)methylamino)-5 '-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity Bioorganic & Medicinal Chemistry  2017 25:5433-5440  DOI:10.1016/j.bmc.2017.07.063  PMID:28807574  PMCID:PMC5632197
    • Brown, C. S., Lee, M. S., Leung, D. W., Wang, T., Xu, W., Luthra, P., Anantpadma, M., Shabman, R. S., Melito, L. M., MacMillan, K. S., Borek, D. M., Otwinowski, Z., et al. In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity Journal of Molecular Biology  2014 426:2045-2058  DOI:10.1016/j.jmb.2014.01.010  PMID:24495995  PMCID:PMC4163021
    • MacMillan, K. S., Naidoo, J., Liang, J., Melito, L., Williams, N. S., Morlock, L., Huntington, P. J., Estill, S. J., Longgood, J., Becker, G. L., McKnight, S. L., Pieper, A. A., et al. Development of proneurogenic, neuroprotective small molecules Journal of the American Chemical Society  2011 133:1428-1437  DOI:10.1021/ja108211m  PMID:21210688  PMCID:PMC3033481
    • Pieper, A. A., Xie, S., Capota, E., Estill, S. J., Zhong, J., Long, J. M., Becker, G. L., Huntington, P., Goldman, S. E., Shen, C. H., Capota, M., Britt, J. K., et al. Discovery of a proneurogenic, neuroprotective chemical Cell  2010 142:39-51  DOI:10.1016/j.cell.2010.06.018  PMID:20603013  PMCID:PMC2930815
    • degree-related publication Boyle, K. E., MacMillan, K. S., Ellis, D. A., Lajiness, J. P., Robertson, W. M., Boger, D. L. Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit Bioorganic & Medicinal Chemistry Letters  2010 20:1854-1857  DOI:10.1016/j.bmcl.2010.01.145  PMID:20171886  PMCID:PMC2965170
    • degree-related publication MacMillan, K. S., Lajiness, J. P., Cara, C. L., Romagnoli, R., Robertson, W. M., Hwang, I., Baraldi, P. G., Boger, D. L. Synthesis and evaluation of a thio analogue of duocarmycin SA Bioorganic & Medicinal Chemistry Letters  2009 19:6962-6965  DOI:10.1016/j.bmcl.2009.10.063  PMID:19879753  PMCID:PMC2784222
    • degree-related publication MacMillan, K. S., Boger, D. L. Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065 Journal of Medicinal Chemistry  2009 52:5771-5780  DOI:10.1021/jm9006214  PMID:19639994  PMCID:PMC2755654
    • degree-related publication Gauss, C. M., Hamasaki, A., Parrish, J. P., MacMillan, K. S., Rayl, T. J., Hwang, I., Boger, D. L. Synthesis and preliminary evaluation of duocarmycin analogues incorporating the 1,2,11,11a-tetrahydrocyclopropa c naphtho 2,3-e indol-4-one (CNI) and 1,2,11,11a-tetrahydrocyclopropa c naphtho 1,2-e indol-4-one (iso-CNI) alkylation subunits Tetrahedron  2009 65:6591-6599  DOI:10.1016/j.tet.2009.02.065  PMID:20161204  PMCID:PMC2713043
    • Tian, Z. Q., Wang, Z., MacMillan, K. S., Zhou, Y., Carreras, C. W., Mueller, T., Myles, D. C., Liu, Y. Potent cytotoxic C-11 modified geldanamycin analogues Journal of Medicinal Chemistry  2009 52:3265-3273  DOI:10.1021/jm900098v  PMID:19405528
    • degree-related publication MacMillan, K. S., Nguyen, T., Hwang, I., Boger, D. L. Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin Journal of the American Chemical Society  2009 131:1187-1194  DOI:10.1021/ja808108q  PMID:19154178  PMCID:PMC2646182
    • degree-related publication MacMillan, K. S., Boger, D. L. An additional spirocyclization for duocarmycin SA Journal of the American Chemical Society  2008 130:16521-16523  DOI:10.1021/ja806593w  PMID:19554689  PMCID:PMC2891557
    • degree-related publication Tichenor, M. S., MacMillan, K. S., Stover, J. S., Wolkenberg, S. E., Pavani, M. G., Zanella, L., Zaid, A. N., Spalluto, G., Rayl, T. J., Hwang, I., Baraldi, P. G., Boger, D. L. Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins Journal of the American Chemical Society  2007 129:14092-14099  DOI:10.1021/ja073989z  PMID:17948994  PMCID:PMC2531197
    • degree-related publication Tichenor, M. S., MacMillan, K. S., Trzupek, J. D., Rayl, T. J., Hwang, I., Boger, D. L. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity Journal of the American Chemical Society  2007 129:10858-10869  DOI:10.1021/ja072777z  PMID:17691783  PMCID:PMC2519902
    • Murli, S., MacMillan, K. S., Hu, Z., Ashley, G. W., Dong, S. D., Kealey, J. T., Reeves, C. D., Kennedy, J. Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1 Applied and Environmental Microbiology  2005 71:4503-4509  DOI:10.1128/aem.71.8.4503-4509.2005  PMID:16085842  PMCID:PMC1183267
    • Dong, S. D., Sundermann, K., Smith, K. M. J., Petryka, J., Liu, F., Myles, D. C. Rapid access to epothilone analogs via semisynthetic degradation and reconstruction of epothilone D Tetrahedron Letters  2004 45:1945-1947  DOI:10.1016/j.tetlet.2003.12.123
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Background

education and training

  • Ph.D. in Chemistry, Scripps Research 2004 - 2009
  • B.S. in Chemistry, University of California, Davis 1998 - 2002

advisee of

  • graduate advising relationship

    • Boger, Dale, Ph.D.  candidacy, 2005 - 2009
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Contact

full name

  • Karen Smith Macmillan

geographic location

  • Scripps California 

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