recent publications
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academic article
- Brockway, A. J., Volkov, O. A., Cosner, C. C., MacMillan, K. S., Wring, S. A., Richardson, T. E., Peel, M., Phillips, M. A., De Brabander, J. K. Synthesis and evaluation of analogs of 5 '-(((Z)-4-amino-2-butenyl)methylamino)-5 '-deoxyadenosine (MDL 73811, or AbeAdo) - An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity Bioorganic & Medicinal Chemistry 2017 25:5433-5440 DOI:10.1016/j.bmc.2017.07.063 PMID:28807574 PMCID:PMC5632197
- Brown, C. S., Lee, M. S., Leung, D. W., Wang, T., Xu, W., Luthra, P., Anantpadma, M., Shabman, R. S., Melito, L. M., MacMillan, K. S., Borek, D. M., Otwinowski, Z., et al. In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity Journal of Molecular Biology 2014 426:2045-2058 DOI:10.1016/j.jmb.2014.01.010 PMID:24495995 PMCID:PMC4163021
- MacMillan, K. S., Naidoo, J., Liang, J., Melito, L., Williams, N. S., Morlock, L., Huntington, P. J., Estill, S. J., Longgood, J., Becker, G. L., McKnight, S. L., Pieper, A. A., et al. Development of proneurogenic, neuroprotective small molecules Journal of the American Chemical Society 2011 133:1428-1437 DOI:10.1021/ja108211m PMID:21210688 PMCID:PMC3033481
- Pieper, A. A., Xie, S., Capota, E., Estill, S. J., Zhong, J., Long, J. M., Becker, G. L., Huntington, P., Goldman, S. E., Shen, C. H., Capota, M., Britt, J. K., et al. Discovery of a proneurogenic, neuroprotective chemical Cell 2010 142:39-51 DOI:10.1016/j.cell.2010.06.018 PMID:20603013 PMCID:PMC2930815
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Boyle, K. E., MacMillan, K. S., Ellis, D. A., Lajiness, J. P., Robertson, W. M., Boger, D. L.
Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit
Bioorganic & Medicinal Chemistry Letters
2010
20:1854-1857
DOI:10.1016/j.bmcl.2010.01.145
PMID:20171886
PMCID:PMC2965170
- Tian, Z. Q., Wang, Z., MacMillan, K. S., Zhou, Y., Carreras, C. W., Mueller, T., Myles, D. C., Liu, Y. Potent cytotoxic C-11 modified geldanamycin analogues Journal of Medicinal Chemistry 2009 52:3265-3273 DOI:10.1021/jm900098v PMID:19405528
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MacMillan, K. S., Boger, D. L.
Fundamental relationships between structure, reactivity, and biological activity for the duocarmycins and CC-1065
Journal of Medicinal Chemistry
2009
52:5771-5780
DOI:10.1021/jm9006214
PMID:19639994
PMCID:PMC2755654
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MacMillan, K. S., Lajiness, J. P., Cara, C. L., Romagnoli, R., Robertson, W. M., Hwang, I., Baraldi, P. G., Boger, D. L.
Synthesis and evaluation of a thio analogue of duocarmycin SA
Bioorganic & Medicinal Chemistry Letters
2009
19:6962-6965
DOI:10.1016/j.bmcl.2009.10.063
PMID:19879753
PMCID:PMC2784222
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Gauss, C. M., Hamasaki, A., Parrish, J. P., MacMillan, K. S., Rayl, T. J., Hwang, I., Boger, D. L.
Synthesis and preliminary evaluation of duocarmycin analogues incorporating the 1,2,11,11a-tetrahydrocyclopropa c naphtho 2,3-e indol-4-one (CNI) and 1,2,11,11a-tetrahydrocyclopropa c naphtho 1,2-e indol-4-one (iso-CNI) alkylation subunits
Tetrahedron
2009
65:6591-6599
DOI:10.1016/j.tet.2009.02.065
PMID:20161204
PMCID:PMC2713043
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MacMillan, K. S., Nguyen, T., Hwang, I., Boger, D. L.
Total synthesis and evaluation of iso-duocarmycin SA and iso-yatakemycin
Journal of the American Chemical Society
2009
131:1187-1194
DOI:10.1021/ja808108q
PMID:19154178
PMCID:PMC2646182
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MacMillan, K. S., Boger, D. L.
An additional spirocyclization for duocarmycin SA
Journal of the American Chemical Society
2008
130:16521-16523
DOI:10.1021/ja806593w
PMID:19554689
PMCID:PMC2891557
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Tichenor, M. S., MacMillan, K. S., Stover, J. S., Wolkenberg, S. E., Pavani, M. G., Zanella, L., Zaid, A. N., Spalluto, G., Rayl, T. J., Hwang, I., Baraldi, P. G., Boger, D. L.
Rational design, synthesis, and evaluation of key analogues of CC-1065 and the duocarmycins
Journal of the American Chemical Society
2007
129:14092-14099
DOI:10.1021/ja073989z
PMID:17948994
PMCID:PMC2531197
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Tichenor, M. S., MacMillan, K. S., Trzupek, J. D., Rayl, T. J., Hwang, I., Boger, D. L.
Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity
Journal of the American Chemical Society
2007
129:10858-10869
DOI:10.1021/ja072777z
PMID:17691783
PMCID:PMC2519902
- Murli, S., MacMillan, K. S., Hu, Z., Ashley, G. W., Dong, S. D., Kealey, J. T., Reeves, C. D., Kennedy, J. Chemobiosynthesis of novel 6-deoxyerythronolide B analogues by mutation of the loading module of 6-deoxyerythronolide B synthase 1 Applied and Environmental Microbiology 2005 71:4503-4509 DOI:10.1128/aem.71.8.4503-4509.2005 PMID:16085842 PMCID:PMC1183267
- Dong, S. D., Sundermann, K., Smith, K. M. J., Petryka, J., Liu, F., Myles, D. C. Rapid access to epothilone analogs via semisynthetic degradation and reconstruction of epothilone D Tetrahedron Letters 2004 45:1945-1947 DOI:10.1016/j.tetlet.2003.12.123