recent publications
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academic article
- Yokota, N., Zarpellon, A., Chakrabarty, S., Bogdanov, V. Y., Gruber, A., Castellino, F. J., Mackman, N., Ellies, L. G., Weiler, H., Ruggeri, Z. M., Ruf, W. Contributions of thrombin targets to tissue factor-dependent metastasis in hyperthrombotic mice Journal of Thrombosis and Haemostasis 2014 12:71-81 DOI:10.1111/jth.12442 PMID:24175924 PMCID:PMC3947224
- Owens, A. P., Passam, F. H., Antoniak, S., Marshall, S. M., McDaniel, A. L., Rudel, L., Williams, J. C., Hubbard, B. K., Dutton, J. A., Wang, J. G., Tobias, P. S., Curtiss, L. K., et al. Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin Journal of Clinical Investigation 2012 122:558-568 DOI:10.1172/jci58969 PMID:22214850 PMCID:PMC3266787
- Liu, Y., Jiang, P. F., Capkova, K., Xue, D., Ye, L. W., Sinha, S. C., Mackman, N., Janda, K. D., Liu, C. Tissue factor-activated coagulation cascade in the tumor microenvironment is critical for tumor progression and an effective target for therapy Cancer Research 2011 71:6492-6502 DOI:10.1158/0008-5472.can-11-1145 PMID:21880589
- Redecha, P., Franzke, C. W., Ruf, W., Mackman, N., Girardi, G. Neutrophil activation by the tissue factor/factor viia/par2 axis mediates fetal death in a mouse model of anti phospholipid syndrome Journal of Clinical Investigation 2008 118:3453-3461 DOI:10.1172/jci36089 PMID:18802482 PMCID:PMC2542852
- Bhattacharjee, G., Ahamed, J., Pawlinski, R., Liu, C., Mackman, N., Ruf, W., Edgington, T. S. Factor xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1 Circulation Research 2008 102:457-464 DOI:10.1161/circresaha.107.167759 PMID:18174463 PMCID:PMC2838720
- Kerschen, E. J., Fernandez, J. A., Cooley, B. C., Yang, X. V., Sood, R., Mosnier, L. O., Castellino, F. J., Mackman, N., Griffin, J. H., Weiler, H. Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C Journal of Experimental Medicine 2007 204:2439-2448 DOI:10.1084/jem.20070404 PMID:17893198 PMCID:PMC2118455
- Shigeoka, A. A., Holscher, T. D., King, A. J., Hallt, F. W., Kiosses, W. B., Tobias, P. S., Mackman, N., McKay, D. B. Tlr2 is constitutively expressed within the kidney and participates in ischemic renal injury through both myd88-dependent and -independent pathways Journal of Immunology 2007 178:6252-6258 PMID:17475853
- Tilley, R. E., Pedersen, B., Pawlinski, R., Sato, Y., Erlich, J. H., Shen, Y. C., Day, S., Huang, Y., Eitzman, D. T., Boisvert, W. A., Curtiss, L. K., Fay, W. P., et al. Atherosclerosis in mice is not affected by a reduction in tissue factor expression Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26:555-562 DOI:10.1161/01.ATV.0000202028.62414.3c PMID:16385085
- Bhattacharjee, G., Ahamed, J., Pedersen, B., El-Sheikh, A., Mackman, N., Ruf, W., Liu, C., Edgington, T. S. Regulation of tissue factor-mediated initiation of the coagulation cascade by cell surface grp78 Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25:1737-1743 DOI:10.1161/01.atv.0000173419.31242.56 PMID:15947236
- Arbibe, L., Mira, J. P., Teusch, N., Kline, L., Guha, M., Mackman, N., Godowski, P. J., Ulevitch, R. J., Knaus, U. G. Toll-like receptor 2-mediated nf-kappa b activation requires a raci-dependent pathway Nature Immunology 2000 1:533-540 DOI:10.1038/82797 PMID:11101877
- Erlich, J., Fearns, C., Mathison, J., Ulevitch, R. J., Mackman, N. Lipopolysaccharide induction of tissue factor expression in rabbits Infection and Immunity 1999 67:2540-2546 PMID:10225918 PMCID:PMC116001
- Bohuslav, J., Kravchenko, V. V., Parry, G. C. N., Erlich, J. H., Gerondakis, S., Mackman, N., Ulevitch, R. J. Regulation of an essential innate immune response by the p50 subunit of NF-kappa B Journal of Clinical Investigation 1998 102:1645-1652 DOI:10.1172/jci3877 PMID:9802878
- Fowler, B., Mackman, N., Parmer, R. J., Miles, L. A. Binding of human single chain urokinase to Chinese hamster ovary cells and cloning of hamster u-PAR Thrombosis and Haemostasis 1998 80:148-154 PMID:9684801
- Yao, J., Mackman, N., Edgington, T. S., Fan, S. T. Lipopolysaccharide induction of the tumor necrosis factor-alpha promoter in human monocytic cells - regulation by egr-1, c-jun, and nf-kappa b transcription factors Journal of Biological Chemistry 1997 272:17795-17801 DOI:10.1074/jbc.272.28.17795 PMID:9211933
- Carmeliet, P., Mackman, N., Moons, L., Luther, T., Gressens, P., VanVlaenderen, I., Demunck, H., Kasper, M., Breier, G., Evrard, P., Muller, M., Risau, W., et al. Role of tissue factor in embryonic blood vessel development Nature 1996 383:73-75 DOI:10.1038/383073a0 PMID:8779717
- GonzalezDunia, D., Eddleston, M., Mackman, N., Carbone, K., delaTorre, J. C. Expression of tissue factor is increased in astrocytes within the central nervous system during persistent infection with Borna disease virus Journal of Virology 1996 70:5812-5820 PMID:8709198 PMCID:PMC190596
- Luther, T., Flossel, C., Mackman, N., Bierhaus, A., Kasper, M., Albrecht, S., Sage, E. H., Iruela-Arispe, L., Grossmann, H., Strohlein, A., Zhang, Y., Nawroth, P. P., et al. Tissue factor expression during human and mouse development American Journal of Pathology 1996 149:101-113 PMID:8686734 PMCID:PMC1865244
- Tipping, P. G., Erlich, J. H., Apostolopoulos, J., Mackman, N., Loskutoff, D., Holdsworth, S. R. Glomerular tissue factor expression in crescentic glomerulonephritis. Correlations between antigen, activity, and mRNA American Journal of Pathology 1995 147:1736-1748 PMID:7495298 PMCID:PMC1869967
- Olman, M. A., Mackman, N., Gladson, C. L., Moser, K. M., Loskutoff, D. J. Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse Journal of Clinical Investigation 1995 96:1621-1630 DOI:10.1172/jci118201 PMID:7544811 PMCID:PMC185788
- Fan, S. T., Mackman, N., Cui, M. Z., Edgington, T. S. Integrin regulation of an inflammatory effector gene - direct induction of the tissue factor promoter by engagement of beta-1 or alpha-4 integrin chains Journal of Immunology 1995 154:3266-3274 PMID:7534794
- Quirk, S. M., Pentecost, B. T., Mackman, N., Loskutoff, D. J., Hartzell, S., Henrikson, K. P. The regulation of uterine tissue factor by estrogen Endocrine 1995 3:177-184 DOI:10.1007/bf02990070 PMID:21153155
- Steinemann, S., Ulevitch, R. J., Mackman, N. Role of the lipopolysaccharide (lps)-binding protein cd14 pathway in lps induction of tissue factor expression in monocytic cells Arteriosclerosis and Thrombosis 1994 14:1202-1209 PMID:7517185
- Brand, K., Banka, C. L., Mackman, N., Terkeltaub, R. A., Fan, S. T., Curtiss, L. K. Oxidized ldl enhances lipopolysaccharide-induced tissue factor expression in human adherent monocytes Arteriosclerosis and Thrombosis 1994 14:790-797 PMID:8172855
- Cui, M. Z., Parry, G. C. N., Edgington, T. S., Mackman, N. Regulation of tissue factor gene-expression in epithelial-cells - induction by serum and phorbol 12-myristate 13-acetate Arteriosclerosis and Thrombosis 1994 14:807-814 PMID:8172857
- Lee, J. D., Kravchenko, V., Kirkland, T. N., Han, J., Mackman, N., Moriarty, A., Leturcq, D., Tobias, P. S., Ulevitch, R. J. Glycosyl-phosphatidylinositol-anchored or integral membrane forms of CD14 mediate identical cellular responses to endotoxin Proceedings of the National Academy of Sciences of the United States of America 1993 90:9930-9934 DOI:10.1073/pnas.90.21.9930 PMID:7694296 PMCID:PMC47686
- Eddleston, M., Delatorre, J. C., Oldstone, M. B. A., Loskutoff, D. J., Edgington, T. S., Mackman, N. Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis Journal of Clinical Investigation 1993 92:349-358 DOI:10.1172/jci116573 PMID:8326003 PMCID:PMC293611
- Mackman, N., Sawdey, M. S., Keeton, M. R., Loskutoff, D. J. Murine tissue factor gene expression in vivo. Tissue and cell specificity and regulation by lipopolysaccharide American Journal of Pathology 1993 143:76-84 PMID:8317556 PMCID:PMC1886940
- Brand, K., Mackman, N., Curtiss, L. K. Interferon-gamma inhibits macrophage apolipoprotein-e production by posttranslational mechanisms Journal of Clinical Investigation 1993 91:2031-2039 DOI:10.1172/jci116425 PMID:8486772
- Fan, S. T., Brian, A. A., Lollo, B. A., Mackman, N., Shen, N. L., Edgington, T. S. Cd11a/cd18 (lfa-1) integrin engagement enhances biosynthesis of early cytokines by activated t-cells Cellular Immunology 1993 148:48-59 DOI:10.1006/cimm.1993.1090 PMID:8098668
- Ollivier, V., Houssaye, S., Ternisien, C., Leon, A., Deverneuil, H., Elbim, C., Mackman, N., Edgington, T. S., Deprost, D. Endotoxin-induced tissue factor messenger-rna in human monocytes is negatively regulated by a cyclic amp-dependent mechanism Blood 1993 81:973-979 PMID:7679011
- Edgington, T. S., Mackman, N., Fan, S. T., Ruf, W. Cellular immune and cytokine pathways resulting in tissue factor expression and relevance to septic shock Nouvelle Revue Francaise d Hematologie 1992 34:S15-S27 PMID:1364116
- Mackman, N., Brand, K., Edgington, T. S. Lipopolysaccharide-mediated transcriptional activation of the human tissue factor gene in thp-1 monocytic cells requires both activator protein-1 and nuclear factor-kappa-b binding-sites Journal of Experimental Medicine 1991 174:1517-1526 DOI:10.1084/jem.174.6.1517 PMID:1744583
- Brand, K., Fowler, B. J., Edgington, T. S., Mackman, N. Tissue factor messenger-rna in thp-1 monocytic cells is regulated at both transcriptional and posttranscriptional levels in response to lipopolysaccharide Molecular and Cellular Biology 1991 11:4732-4738 PMID:1875949 PMCID:PMC361371
- Edgington, T. S., Mackman, N., Brand, K., Ruf, W. The structural biology of expression and function of tissue factor Thrombosis and Haemostasis 1991 66:67-79 PMID:1833852
- Andrews, B. S., Rehemtulla, A., Fowler, B. J., Edgington, T. S., Mackman, N. Conservation of tissue factor primary sequence among 3 mammalian-species Gene 1991 98:265-269 DOI:10.1016/0378-1119(91)90184-d PMID:1840552
- Mackman, N., Fowler, B. J., Edgington, T. S., Morrissey, J. H. Functional-analysis of the human tissue factor promoter and induction by serum Proceedings of the National Academy of Sciences of the United States of America 1990 87:2254-2258 DOI:10.1073/pnas.87.6.2254 PMID:2315317
- Mackman, N., Morrissey, J. H., Fowler, B., Edgington, T. S. Complete sequence of the human-tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade Biochemistry 1989 28:1755-1762 DOI:10.1021/bi00430a050 PMID:2719931