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Lum, Kenneth
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Lum, Kenneth

Graduate Student
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Positions

  • 2011 Summer/Winter Intern, Cravatt Laboratory, Scripps Research
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Publications

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  • academic article

    • degree-related publication Carvalho, L. A. R., Almeida, V. T., Brito, J. A., Lum, K. M., Oliveira, T. F., Guedes, R. C., Goncalves, L. M., Lucas, S. D., Cravatt, B. F., Archer, M., Moreira, R. 3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling ACS Chemical Biology  2020 15:878-883  DOI:10.1021/acschembio.0c00090  PMID:32176480
    • degree-related publication Vinogradova, E. V., Zhang, X. Y., Remillard, D., Lazar, D. C., Suciu, R. M., Wang, Y. J., Bianco, G., Yamashita, Y., Crowley, V. M., Schafroth, M. A., Yokoyama, M., Konrad, D. B., et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells Cell  2020 182:1009-1026  DOI:10.1016/j.cell.2020.07.001  PMID:32730809
    • degree-related publication Chen, A. L., Lum, K. M., Lara-Gonzalez, P., Ogasawara, D., Cognetta III, A. B., To, A., Parsons, W. H., Simon, G. M., Desai, A., Petrascheck, M., Bar-Peled, L., Cravatt, B. F. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan Nature Chemical Biology  2019 15:453-462  DOI:10.1038/s41589-019-0243-4  PMID:30911178  PMCID:PMC6548519
    • degree-related publication Tan, J., Cognetta III, A. B., Diaz, D. B., Lum, K. M., Adachi, S., Kundu, S., Cravatt, B. F., Yudin, A. K. Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors Nature Communications  2017 8  DOI:10.1038/s41467-017-01319-4  PMID:29170371  PMCID:PMC5701053
    • degree-related publication Lum, K. M., Sato, Y., Beyer, B. A., Plaisted, W. C., Anglin, J. L., Lairson, L. L., Cravatt, B. F. Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics ACS Chemical Biology  2017 12:2671-2681  DOI:10.1021/acschembio.7b00581  PMID:28930429  PMCID:PMC5650530
    • degree-related publication Zaro, B. W., Whitby, L. R., Lum, K. M., Cravatt, B. F. Metabolically labile fumarate esters impart kinetic selectivity to irreversible inhibitors Journal of the American Chemical Society  2016 138:15841-15844  DOI:10.1021/jacs.6b10589  PMID:27960302  PMCID:PMC5273863
    • degree-related publication Villa, G. R., Hulce, J. J., Zanca, C., Bi, J., Ikegami, S., Cahill, G. L., Gu, Y., Lum, K. M., Masui, K., Yang, H., Rong, X., Hong, C., et al. An LXR-cholesterol axis creates a metabolic co-dependency for brain cancers Cancer Cell  2016 30:683-693  DOI:10.1016/j.ccell.2016.09.008  PMID:27746144
    • degree-related publication Horning, B. D., Suciu, R. M., Ghadiri, D. A., Ulanovskaya, O. A., Matthews, M. L., Lum, K. M., Backus, K. M., Brown, S. J., Rosen, H., Cravatt, B. F. Chemical proteomic profiling of human methyltransferases Journal of the American Chemical Society  2016 138:13335-13343  DOI:10.1021/jacs.6b07830  PMID:27689866  PMCID:PMC5072128
    • degree-related publication Backus, K. M., Correia, B. E., Lum, K. M., Forli, S., Horning, B. D., Gonzalez-Paez, G. E., Chatterjee, S., Lanning, B. R., Teijaro, J. R., Olson, A. J., Wolan, D. W., Cravatt, B. F. Proteome-wide covalent ligand discovery in native biological systems Nature  2016 534:570-574  DOI:10.1038/nature18002  PMID:27309814  PMCID:PMC4919207
    • degree-related publication Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Correia, B. E., Ichu, T. A., Olucha, J., Brown, S. J., Kundu, S., Piscitelli, F., Rosen, H., Cravatt, B. F. A global map of lipid-binding proteins and their ligandability in cells Cell  2015 161:1668-1680  DOI:10.1016/j.cell.2015.05.045  PMID:26091042  PMCID:PMC4615699
    • Lum, K. M., Xavier, V. J., Ong, M. J. H., Johannes, C. W., Chan, K. P. Stabilized Wittig olefination for bioconjugation Chemical Communications  2013 49:11188-11190  DOI:10.1039/c3cc45961f  PMID:24150718
    • Chang, J. W., Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Wang, C., Matthews, M. L., Niessen, S., Buczynski, M. W., Parsons, L. H., Cravatt, B. F. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates Chemistry & Biology  2012 19:579-588  DOI:10.1016/j.chembiol.2012.03.009  PMID:22542104  PMCID:PMC3361572
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Background

education and training

  • Ph.D. in Chemical Biology, Scripps Research 2013 - 2018
  • B.A. in Chemistry, Carleton College 2008 - 2012

advisee of

  • graduate advising relationship

    • Cravatt, Benjamin, Ph.D.  candidacy, 2014 - 2018
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Contact

full name

  • Kenneth Meng Yun Lum

geographic location

  • Scripps California 

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