recent publications
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academic article
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Carvalho, L. A. R., Almeida, V. T., Brito, J. A., Lum, K. M., Oliveira, T. F., Guedes, R. C., Goncalves, L. M., Lucas, S. D., Cravatt, B. F., Archer, M., Moreira, R.
3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling
ACS Chemical Biology
2020
15:878-883
DOI:10.1021/acschembio.0c00090
PMID:32176480
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Vinogradova, E. V., Zhang, X. Y., Remillard, D., Lazar, D. C., Suciu, R. M., Wang, Y. J., Bianco, G., Yamashita, Y., Crowley, V. M., Schafroth, M. A., Yokoyama, M., Konrad, D. B., et al.
An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
Cell
2020
182:1009-1026
DOI:10.1016/j.cell.2020.07.001
PMID:32730809
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Chen, A. L., Lum, K. M., Lara-Gonzalez, P., Ogasawara, D., Cognetta III, A. B., To, A., Parsons, W. H., Simon, G. M., Desai, A., Petrascheck, M., Bar-Peled, L., Cravatt, B. F.
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan
Nature Chemical Biology
2019
15:453-462
DOI:10.1038/s41589-019-0243-4
PMID:30911178
PMCID:PMC6548519
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Tan, J., Cognetta III, A. B., Diaz, D. B., Lum, K. M., Adachi, S., Kundu, S., Cravatt, B. F., Yudin, A. K.
Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors
Nature Communications
2017
8
DOI:10.1038/s41467-017-01319-4
PMID:29170371
PMCID:PMC5701053
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Lum, K. M., Sato, Y., Beyer, B. A., Plaisted, W. C., Anglin, J. L., Lairson, L. L., Cravatt, B. F.
Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics
ACS Chemical Biology
2017
12:2671-2681
DOI:10.1021/acschembio.7b00581
PMID:28930429
PMCID:PMC5650530
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Zaro, B. W., Whitby, L. R., Lum, K. M., Cravatt, B. F.
Metabolically labile fumarate esters impart kinetic selectivity to irreversible inhibitors
Journal of the American Chemical Society
2016
138:15841-15844
DOI:10.1021/jacs.6b10589
PMID:27960302
PMCID:PMC5273863
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Villa, G. R., Hulce, J. J., Zanca, C., Bi, J., Ikegami, S., Cahill, G. L., Gu, Y., Lum, K. M., Masui, K., Yang, H., Rong, X., Hong, C., et al.
An LXR-cholesterol axis creates a metabolic co-dependency for brain cancers
Cancer Cell
2016
30:683-693
DOI:10.1016/j.ccell.2016.09.008
PMID:27746144
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Horning, B. D., Suciu, R. M., Ghadiri, D. A., Ulanovskaya, O. A., Matthews, M. L., Lum, K. M., Backus, K. M., Brown, S. J., Rosen, H., Cravatt, B. F.
Chemical proteomic profiling of human methyltransferases
Journal of the American Chemical Society
2016
138:13335-13343
DOI:10.1021/jacs.6b07830
PMID:27689866
PMCID:PMC5072128
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Backus, K. M., Correia, B. E., Lum, K. M., Forli, S., Horning, B. D., Gonzalez-Paez, G. E., Chatterjee, S., Lanning, B. R., Teijaro, J. R., Olson, A. J., Wolan, D. W., Cravatt, B. F.
Proteome-wide covalent ligand discovery in native biological systems
Nature
2016
534:570-574
DOI:10.1038/nature18002
PMID:27309814
PMCID:PMC4919207
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Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Correia, B. E., Ichu, T. A., Olucha, J., Brown, S. J., Kundu, S., Piscitelli, F., Rosen, H., Cravatt, B. F.
A global map of lipid-binding proteins and their ligandability in cells
Cell
2015
161:1668-1680
DOI:10.1016/j.cell.2015.05.045
PMID:26091042
PMCID:PMC4615699
- Lum, K. M., Xavier, V. J., Ong, M. J. H., Johannes, C. W., Chan, K. P. Stabilized Wittig olefination for bioconjugation Chemical Communications 2013 49:11188-11190 DOI:10.1039/c3cc45961f PMID:24150718
- Chang, J. W., Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Wang, C., Matthews, M. L., Niessen, S., Buczynski, M. W., Parsons, L. H., Cravatt, B. F. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates Chemistry & Biology 2012 19:579-588 DOI:10.1016/j.chembiol.2012.03.009 PMID:22542104 PMCID:PMC3361572
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