recent publications
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academic article
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Carvalho, L. A. R., Almeida, V. T., Brito, J. A., Lum, K. M., Oliveira, T. F., Guedes, R. C., Goncalves, L. M., Lucas, S. D., Cravatt, B. F., Archer, M., Moreira, R. 3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling ACS Chemical Biology 2020 15:878-883 DOI:10.1021/acschembio.0c00090 PMID:32176480
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Vinogradova, E. V., Zhang, X. Y., Remillard, D., Lazar, D. C., Suciu, R. M., Wang, Y. J., Bianco, G., Yamashita, Y., Crowley, V. M., Schafroth, M. A., Yokoyama, M., Konrad, D. B., et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells Cell 2020 182:1009-1026 DOI:10.1016/j.cell.2020.07.001 PMID:32730809
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Chen, A. L., Lum, K. M., Lara-Gonzalez, P., Ogasawara, D., Cognetta III, A. B., To, A., Parsons, W. H., Simon, G. M., Desai, A., Petrascheck, M., Bar-Peled, L., Cravatt, B. F. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan Nature Chemical Biology 2019 15:453-462 DOI:10.1038/s41589-019-0243-4 PMID:30911178 PMCID:PMC6548519
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Tan, J., Cognetta III, A. B., Diaz, D. B., Lum, K. M., Adachi, S., Kundu, S., Cravatt, B. F., Yudin, A. K. Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors Nature Communications 2017 8 DOI:10.1038/s41467-017-01319-4 PMID:29170371 PMCID:PMC5701053
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Lum, K. M., Sato, Y., Beyer, B. A., Plaisted, W. C., Anglin, J. L., Lairson, L. L., Cravatt, B. F. Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics ACS Chemical Biology 2017 12:2671-2681 DOI:10.1021/acschembio.7b00581 PMID:28930429 PMCID:PMC5650530
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Zaro, B. W., Whitby, L. R., Lum, K. M., Cravatt, B. F. Metabolically labile fumarate esters impart kinetic selectivity to irreversible inhibitors Journal of the American Chemical Society 2016 138:15841-15844 DOI:10.1021/jacs.6b10589 PMID:27960302 PMCID:PMC5273863
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Villa, G. R., Hulce, J. J., Zanca, C., Bi, J., Ikegami, S., Cahill, G. L., Gu, Y., Lum, K. M., Masui, K., Yang, H., Rong, X., Hong, C., et al. An LXR-cholesterol axis creates a metabolic co-dependency for brain cancers Cancer Cell 2016 30:683-693 DOI:10.1016/j.ccell.2016.09.008 PMID:27746144
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Horning, B. D., Suciu, R. M., Ghadiri, D. A., Ulanovskaya, O. A., Matthews, M. L., Lum, K. M., Backus, K. M., Brown, S. J., Rosen, H., Cravatt, B. F. Chemical proteomic profiling of human methyltransferases Journal of the American Chemical Society 2016 138:13335-13343 DOI:10.1021/jacs.6b07830 PMID:27689866 PMCID:PMC5072128
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Backus, K. M., Correia, B. E., Lum, K. M., Forli, S., Horning, B. D., Gonzalez-Paez, G. E., Chatterjee, S., Lanning, B. R., Teijaro, J. R., Olson, A. J., Wolan, D. W., Cravatt, B. F. Proteome-wide covalent ligand discovery in native biological systems Nature 2016 534:570-574 DOI:10.1038/nature18002 PMID:27309814 PMCID:PMC4919207
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Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Correia, B. E., Ichu, T. A., Olucha, J., Brown, S. J., Kundu, S., Piscitelli, F., Rosen, H., Cravatt, B. F. A global map of lipid-binding proteins and their ligandability in cells Cell 2015 161:1668-1680 DOI:10.1016/j.cell.2015.05.045 PMID:26091042 PMCID:PMC4615699
- Lum, K. M., Xavier, V. J., Ong, M. J. H., Johannes, C. W., Chan, K. P. Stabilized Wittig olefination for bioconjugation Chemical Communications 2013 49:11188-11190 DOI:10.1039/c3cc45961f PMID:24150718
- Chang, J. W., Niphakis, M. J., Lum, K. M., Cognetta III, A. B., Wang, C., Matthews, M. L., Niessen, S., Buczynski, M. W., Parsons, L. H., Cravatt, B. F. Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates Chemistry & Biology 2012 19:579-588 DOI:10.1016/j.chembiol.2012.03.009 PMID:22542104 PMCID:PMC3361572
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