recent publications
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academic article
- Duffy, T., Bekki, H., Lotz, M. K. Genome-Wide Occupancy Profiling Reveals Critical Roles of FoxO1 in Regulating Extracellular Matrix and Circadian Rhythm Genes in Human Chondrocytes Arthritis & Rheumatology 2020 DOI:10.1002/art.41284 PMID:32281255
- Bekki, H., Duffy, T., Okubo, N., Olmer, M., Alvarez-Garcia, O., Lamia, K., Kay, S., Lotz, M. Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis Osteoarthritis and Cartilage 2020 28:966-976 DOI:10.1016/j.joca.2020.04.004 PMID:32339698
- Nagira, K., Ikuta, Y., Shinohara, M., Sanada, Y., Omoto, T., Kanaya, H., Nakasa, T., Ishikawa, M., Adachi, N., Miyaki, S., Lotz, M. Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis Scientific Reports 2020 10 DOI:10.1038/s41598-020-66979-7 PMID:32572077 PMCID:PMC7308327
- Kataoka, K., Kurimoto, R., Tsutsumi, H., Chiba, T., Shishido, K., Kato, M., Ito, Y., Cho, Y., Hoshi, O., Mimata, A., Sakamaki, Y., Nakamichi, R. In vitro Neo-Genesis of Tendon/Ligament-Like Tissue by Combination of Mohawk and a Three-Dimensional Cyclic Mechanical Stretch Culture System Frontiers in Cell and Developmental Biology 2020 8 DOI:10.3389/fcell.2020.00307 PMID:32671057 PMCID:PMC7326056
- Sueishi, T., Akasaki, Y., Goto, N., Kurakazu, I., Toya, M., Kuwahara, M., Uchida, T., Hayashida, M., Tsushima, H., Bekki, H., Lotz, M. K., Nakashima, Y. GRK5 inhibition attenuates cartilage degradation via decreased NF-κB signaling Arthritis & Rheumatology 2020 72:620-631 DOI:10.1002/art.41152 PMID:31696655
- Lee, K. I., Choi, S., Matsuzaki, T., Alvarez-Garcia, O., Olmer, M., Grogan, S. P., D'Lima, D. D., Lotz, M. K. FOXO1 and FOXO3 transcription factors have unique functions in meniscus development and homeostasis during aging and osteoarthritis Proceedings of the National Academy of Sciences of the United States of America 2020 117:3135-3143 DOI:10.1073/pnas.1918673117 PMID:31980519 PMCID:PMC7022148
- Lee, K. I., Gamini, R., Olmer, M., Ikuta, Y., Hasei, J., Baek, J., Alvarez-Garcia, O., Grogan, S. P., D'Lima, D., Asahara, H., Su, A. I., Lotz, M. K. Mohawk is a transcription factor that promotes meniscus cell phenotype and tissue repair and reduces osteoarthritis severity Science Translational Medicine 2020 12 DOI:10.1126/scitranslmed.aan7967 PMID:33115953 PMCID:PMC7955769
- Mailhiot, S. E., Thompson, M. A., Eguchi, A. E., Dinkel, S. E., Lotz, M. K., Dowdy, S. F., June, R. K. The TAT Protein Transduction Domain as an Intra-Articular Drug Delivery Technology Cartilage 2020 DOI:10.1177/1947603520959392 PMID:32954793
- Baek, J., Lee, E., Lotz, M. K., D'Lima, D. D. Bioactive proteins delivery through core-shell nanofibers for meniscal tissue regeneration Nanomedicine-Nanotechnology Biology and Medicine 2020 23 DOI:10.1016/j.nano.2019.102090 PMID:31493556 PMCID:PMC6911641
- Baek, J., Lotz, M. K., D'Lima, D. D. Core-shell nanofibrous scaffolds for repair of meniscus tears Tissue Engineering Part A 2019 DOI:10.1089/ten.tea.2018.0319 PMID:30950316
- Kurakazu, I., Akasaki, Y., Hayashida, M., Tsushima, H., Goto, N., Sueishi, T., Toya, M., Kuwahara, M., Okazaki, K., Duffy, T., Lotz, M. K., Nakashima, Y. FOXO1 transcription factor regulates chondrogenic differentiation through transforming growth factor β1 signaling Journal of Biological Chemistry 2019 294:17555-17569 DOI:10.1074/jbc.RA119.009409 PMID:31601652 PMCID:PMC6873195
- Wyseure, T., Yang, T., Zhou, J. Y., Cooke, E. J., Wanko, B., Olmer, M., Agashe, R., Morodomi, Y., Behrendt, N., Lotz, M., Morser, J., von Drygalski, A., et al. TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding JCI Insight 2019 4 DOI:10.1172/jci.insight.128379 PMID:31465300
- Otsuki, S., Alvarez-Garcia, O., Lotz, M. K., Neo, M. Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis Histology and Histopathology 2019 34:1051-1060 DOI:10.14670/hh-18-107 PMID:30924907
- Nogueira-Recalde, U., Lorenzo-Gomez, I., Blanco, F. J., Loza, M. I., Grassi, D., Shirinsky, V., Shirinsky, I., Lotz, M., Robbins, P. D., Dominguez, E., Carames, B. Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy Ebiomedicine 2019 45:588-605 DOI:10.1016/j.ebiom.2019.06.049 PMID:31285188 PMCID:PMC6642320
- Fisch, K. M., Gamini, R., Alvarez-Garcia, O., Akagi, R., Saito, M., Muramatsu, Y., Sasho, T., Koziol, J. A., Su, A. I., Lotz, M. K. Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis Osteoarthritis Cartilage 2018 1531-1538 DOI:10.1016/j.joca.2018.07.012 PMID:30081074
- Kumar, P., Yao, L. J., Saidin, S., Paleja, B., Van Loosdregt, J., Chua, C., Arkachaisri, T., Consolaro, A., Gattorno, M., Martini, A., Pischel, K. D., Williams, G. W., et al. Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis Journal of Autoimmunity 2018 94:90-98 DOI:10.1016/j.jaut.2018.07.014 PMID:30077426
- Alvarez-Garcia, O., Matsuzaki, T., Olmer, M., Miyata, K., Mokuda, S., Sakai, D., Masuda, K., Asahara, H., Lotz, M. K. FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration Aging Cell 2018 17 DOI:10.1111/acel.12800 PMID:29963746 PMCID:PMC6156454
- Chen, L. Y., Lotz, M., Terkeltaub, R., Liu-Bryan, R. Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes Journal of Biological Chemistry 2018 293:12259-12270 DOI:10.1074/jbc.RA118.002261 PMID:29929979 PMCID:PMC6078460
- Lee, K. I., Olmer, M., Baek, J., D'Lima, D. D., Lotz, M. K. Platelet-derived growth factor-coated decellularized meniscus scaffold for integrative healing of meniscus tears Acta Biomaterialia 2018 76:126-134 DOI:10.1016/j.actbio.2018.06.021 PMID:29908335 PMCID:PMC6090559
- Ishitobi, H., Sanada, Y., Kato, Y., Ikuta, Y., Shibata, S., Yamasaki, S., Lotz, M. K., Matsubara, K., Miyaki, S., Adachi, N. Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes European Journal of Pharmacology 2018 830:1-8 DOI:10.1016/j.ejphar.2018.04.018 PMID:29678719
- Grogan, S. P., Duffy, S. F., Pauli, C., Lotz, M. K., D'Lima, D. D. Gene expression profiles of the meniscus avascular phenotype: A guide for meniscus tissue engineering Journal of Orthopaedic Research 2018 36:1947-1958 DOI:10.1002/jor.23864 PMID:29411909
- Serrano, R. L., Chen, L. Y., Lotz, M. K., Liu-Bryan, Ru, Terkeltaub, R. Impaired proteasomal function in human osteoarthritic chondrocytes can contribute to decreased levels of SOX9 and aggrecan Arthritis & Rheumatology 2018 70:1030-1041 DOI:10.1002/art.40456 PMID:29457374 PMCID:PMC6019618
- Lee, D., Taniguchi, N., Sato, K., Choijookhuu, N., Hishikawa, Y., Kataoka, H., Morinaga, H., Lotz, M., Chosa, E. HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles Scientific Reports 2018 8 DOI:10.1038/s41598-018-28023-7 PMID:29942000 PMCID:PMC6018498
- Matsuzaki, T., Alvarez-Garcia, O., Mokuda, S., Nagira, K., Olmer, M., Gamini, R., Miyata, K., Akasaki, Y., Su, A. I., Asahara, H., Lotz, M. K. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis Science Translational Medicine 2018 10:eaan0746 DOI:10.1126/scitranslmed.aan0746 PMID:29444976
- Miyaki, S., Lotz, M. K. Extracellular vesicles in cartilage homeostasis and osteoarthritis Current Opinion in Rheumatology 2018 30:129-135 DOI:10.1097/bor.0000000000000454 PMID:29035932 PMCID:PMC5810945
- Taniguchi, N., Kawakami, Y., Maruyama, I., Lotz, M. HMGB proteins and arthritis Human Cell 2018 31:1-9 DOI:10.1007/s13577-017-0182-x PMID:28916968
- Alvarez-Garcia, O., Matsuzaki, T., Olmer, M., Masuda, K., Lotz, M. K. Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration Journal of Orthopaedic Research 2017 35:2682-2691 DOI:10.1002/jor.23583 PMID:28430387 PMCID:PMC5650945
- Meckes, J. K., Carames, B., Olmer, M., Kiosses, W. B., Grogan, S. P., Lotz, M. K., D'Lima, D. D. Compromised autophagy precedes meniscus degeneration and cartilage damage in mice Osteoarthritis and Cartilage 2017 25:1880-1889 DOI:10.1016/j.joca.2017.07.023 PMID:28801209 PMCID:PMC5650923
- Peeters, J. G. C., de Graeff, N., Lotz, M., Albani, S., de Roock, S., van Loosdregt, J. Increased autophagy contributes to the inflammatory phenotype of juvenile idiopathic arthritis synovial fluid T cells Rheumatology 2017 56:1694-1699 DOI:10.1093/rheumatology/kex227 PMID:28957547
- Asahara, H., Inui, M., Lotz, M. K. Tendons and ligaments: connecting developmental biology to musculoskeletal disease pathogenesis Journal of Bone and Mineral Research 2017 32:1773-1782 DOI:10.1002/jbmr.3199 PMID:28621492
- Yu, X., Kawakami, H., Tahara, N., Olmer, M., Hayashi, S., Akiyama, R., Bagchi, A., Lotz, M., Kawakami, Y. Expression of Noggin and Gremlin1 and its implications in fine-tuning BMP activities in mouse cartilage tissues Journal of Orthopaedic Research 2017 35:1671-1682 DOI:10.1002/jor.23463 PMID:27769098
- Alvarez-Garcia, O., Matsuzaki, T., Olmer, M., Plate, L., Kelly, J. W., Lotz, M. K. Regulated in development and DNA Damage response 1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental osteoarthritis Arthritis & Rheumatology 2017 69:1418-1428 DOI:10.1002/art.40104 PMID:28334504 PMCID:PMC5489357
- Akagi, R., Akatsu, Y., Fisch, K. M., Alvarez-Garcia, O., Teramura, T., Muramatsu, Y., Saito, M., Sasho, T., Su, A. I., Lotz, M. K. Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes Osteoarthritis and Cartilage 2017 25:943-951 DOI:10.1016/j.joca.2016.11.007 PMID:27884645 PMCID:PMC5438901
- Hasegawa, A., Yonezawa, T., Taniguchi, N., Otabe, K., Akasaki, Y., Matsukawa, T., Saito, M., Neo, M., Marmorstein, L. Y., Lotz, M. K. Role of fibulin 3 in aging-related joint changes and osteoarthritis pathogenesis in human and mouse knee cartilage Arthritis & Rheumatology 2017 69:576-585 DOI:10.1002/art.39963 PMID:27780308 PMCID:PMC5328782
- Rodeo, S., Buckwalter, J. A., Lotz, M. Special issue: Injury and post-traumatic osteoarthritis Journal of Orthopaedic Research 2017 35:395-396 DOI:10.1002/jor.23546 PMID:28297745
- Hasei, J., Teramura, T., Takehara, T., Onodera, Y., Horii, T., Olmer, M., Hatada, I., Fukuda, K., Ozaki, T., Lotz, M. K., Asahara, H. TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes Scientific Reports 2017 7 DOI:10.1038/srep42990 PMID:28220902 PMCID:PMC5318945
- Shen, T., Alvarez-Garcia, O., Li, Y., Olmer, M., Lotz, M. K. Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism Osteoarthritis and Cartilage 2017 25:287-296 DOI:10.1016/j.joca.2016.09.017 PMID:27693501 PMCID:PMC5258682
- Matsuzaki, T., Akasaki, Y., Olmer, M., Alvarez-Garcia, O., Reixach, N., Buxbaum, J. N., Lotz, M. K. Transthyretin deposition promotes progression of osteoarthritis Aging Cell 2017 16:1313-1322 DOI:10.1111/acel.12665 PMID:28941045 PMCID:PMC5676063
- Grogan, S. P., Pauli, C., Lotz, M. K., D'Lima, D. D. Relevance of meniscal cell regional phenotype to tissue engineering Connective Tissue Research 2017 58:259-270 DOI:10.1080/03008207.2016.1268604 PMID:27925477 PMCID:PMC5433889
- van Loosdregt, J., Rossetti, M., Spreafico, R., Moshref, M., Olmer, M., Williams, G. W., Kumar, P., Copeland, D., Pischel, K., Lotz, M., Albani, S. Increased autophagy in CD4(+) T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance European Journal of Immunology 2016 46:2862-2870 DOI:10.1002/eji.201646375 PMID:27624289 PMCID:PMC5138112
- Alvarez-Garcia, O., Olmer, M., Akagi, R., Akasaki, Y., Fisch, K. M., Shen, T., Su, A. I., Lotz, M. K. Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy Osteoarthritis and Cartilage 2016 24:1639-1647 DOI:10.1016/j.joca.2016.04.015 PMID:27118398 PMCID:PMC4992644
- Alvarez-Garcia, O., Fisch, K. M., Wineinger, N. E., Akagi, R., Saito, M., Sasho, T., Su, A. I., Lotz, M. K. Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage Arthritis & Rheumatology 2016 68:1876-1886 DOI:10.1002/art.39643 PMID:26881698 PMCID:PMC4963260
- Nakamichi, R., Ito, Y., Inui, M., Onizuka, N., Kayama, T., Kataoka, K., Suzuki, H., Mori, M., Inagawa, M., Ichinose, S., Lotz, M. K., Sakai, D., et al. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs Nature Communications 2016 7 DOI:10.1038/ncomms12503 PMID:27527664 PMCID:PMC4990710
- Suzuki, H., Ito, Y., Shinohara, M., Yamashita, S., Ichinose, S., Kishida, A., Oyaizu, T., Kayama, T., Nakamichi, R., Koda, N., Yagishita, K., Lotz, M. K., et al. Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis Proceedings of the National Academy of Sciences of the United States of America 2016 113:7840-7845 DOI:10.1073/pnas.1522054113 PMID:27370800 PMCID:PMC4948356
- D'Adamo, S., Alvarez-Garcia, O., Muramatsu, Y., Flamigni, F., Lotz, M. K. MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins Osteoarthritis and Cartilage 2016 24:1082-1091 DOI:10.1016/j.joca.2016.01.005 PMID:26805019 PMCID:PMC4875787
- Kwok, J., Onuma, H., Olmer, M., Lotz, M. K., Grogan, S. P., D'Lima, D. D. Histopathological analyses of murine menisci: implications for joint aging and osteoarthritis Osteoarthritis and Cartilage 2016 24:709-718 DOI:10.1016/j.joca.2015.11.006 PMID:26585241 PMCID:PMC4799761
- Temple-Wong, M. M., Ren, S., Quach, P., Hansen, B. C., Chen, A. C., Hasegawa, A., D'Lima, D. D., Koziol, J., Masuda, K., Lotz, M. K., Sah, R. L. Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration Arthritis Research & Therapy 2016 18 DOI:10.1186/s13075-016-0922-4 PMID:26792492 PMCID:PMC4721052
- Takada, T., Miyaki, S., Ishitobi, H., Hirai, Y., Nakasa, T., Igarashi, K., Lotz, M. K., Ochi, M. Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1 Arthritis Research & Therapy 2015 17:285 DOI:10.1186/s13075-015-0792-1 PMID:26458773 PMCID:PMC4603301
- Wang, Y., Zhao, X., Lotz, M., Terkeltaub, R., Liu-Bryan, R. Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α. Arthritis & Rheumatology 2015 67:2141-2153 DOI:10.1002/art.39182 PMID:25940958 PMCID:PMC4519411
- Akasaki, Y., Reixach, N., Matsuzaki, T., Alvarez-Garcia, O., Olmer, M., Iwamoto, Y., Buxbaum, J. N., Lotz, M. K. Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis Arthritis & Rheumatology 2015 67:2097-2107 DOI:10.1002/art.39178 PMID:25940564 PMCID:PMC4519374
- Carames, B., Olmer, M., Kiosses, W. B., Lotz, M. K. The relationship of autophagy defects to cartilage damage during joint aging in a mouse model Arthritis & Rheumatology 2015 67:1568-1576 DOI:10.1002/art.39073 PMID:25708836 PMCID:PMC4446178
- Yamanaka, Y., Faghihi, M. A., Magistri, M., Alvarez-Garcia, O., Lotz, M., Wahlestedt, C. Antisense RNA controls LRP1 sense transcript expression through interaction with a chromatin-associated protein, HMGB2 Cell Reports 2015 11:967-976 DOI:10.1016/j.celrep.2015.04.011 PMID:25937287 PMCID:PMC4431949
- Lopez de Figueroa, P., Lotz, M. K., Blanco, F. J., Carames, B. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes Arthritis & Rheumatology 2015 67:966-976 DOI:10.1002/art.39025 PMID:25605458 PMCID:PMC4380780
- Hoshiyama, Y., Otsuki, S., Oda, S., Kurokawa, Y., Nakajima, M., Jotoku, T., Tamura, R., Okamoto, Y., Lotz, M. K., Neo, M. Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells Journal of Orthopaedic Research 2015 33:548-555 DOI:10.1002/jor.22782 PMID:25691232 PMCID:PMC4454425
- Otabe, K., Nakahara, H., Hasegawa, A., Matsukawa, T., Ayabe, F., Onizuka, N., Inui, M., Takada, S., Ito, Y., Sekiya, I., Muneta, T., Lotz, M., et al. Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo Journal of Orthopaedic Research 2015 33:1-8 DOI:10.1002/jor.22750 PMID:25312837 PMCID:PMC4294629
- Akasaki, Y., Alvarez-Garcia, O., Saito, M., Carames, B., Iwamoto, Y., Lotz, M. K. FoxO transcription factors support oxidative stress resistance in human chondrocytes Arthritis & Rheumatology 2014 66:3349-3358 DOI:10.1002/art.38868 PMID:25186470 PMCID:PMC4254812
- Zhao, X., Petursson, F., Viollet, B., Lotz, M., Terkeltaub, R., Liu-Bryan, R. Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase Arthritis & Rheumatology 2014 66:3073-3082 DOI:10.1002/art.38791 PMID:25047750 PMCID:PMC4343036
- Alvarez-Garcia, O., Rogers, N. H., Smith, R. G., Lotz, M. K. Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1 Arthritis & Rheumatology 2014 66:1779-1788 DOI:10.1002/art.38399 PMID:24591481 PMCID:PMC4077915
- Olee, T., Grogan, S. P., Lotz, M. K., Colwell, C. W., D'Lima, D. D., Snyder, E. Y. Repair of cartilage defects in arthritic tissue with differentiated human embryonic stem cells Tissue Engineering Part A 2014 20:683-692 DOI:10.1089/ten.tea.2012.0751 PMID:24028447 PMCID:PMC3926163
- Shapiro, I. M., Layfield, R., Lotz, M., Settembre, C., Whitehouse, C. Boning up on autophagy: the role of autophagy in skeletal biology Autophagy 2014 10:7-19 DOI:10.4161/auto.26679 PMID:24225636 PMCID:PMC4028324
- Akasaki, Y., Hasegawa, A., Saito, M., Asahara, H., Iwamoto, Y., Lotz, M. K. Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis Osteoarthritis and Cartilage 2014 22:162-170 DOI:10.1016/j.joca.2013.11.004 PMID:24269635 PMCID:PMC3932989
- Kato, T., Miyaki, S., Ishitobi, H., Nakamura, Y., Nakasa, T., Lotz, M. K., Ochi, M. Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes Arthritis Research & Therapy 2014 16:R163 DOI:10.1186/ar4679 PMID:25092378 PMCID:PMC4261911
- Grogan, S. P., Chen, X., Sovani, S., Taniguchi, N., Colwell Jr., C. W., Lotz, M. K., D'Lima, D. D. Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation Tissue Engineering Part A 2014 20:264-274 DOI:10.1089/ten.tea.2012.0618 PMID:23962090 PMCID:PMC3875188
- Onizuka, N., Ito, Y., Inagawa, M., Nakahara, H., Takada, S., Lotz, M., Toyama, Y., Asahara, H. The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates Journal of Orthopaedic Science 2014 19:172-180 DOI:10.1007/s00776-013-0485-z PMID:24166359 PMCID:PMC3943675
- Yoshitaka, T., Kawai, A., Miyaki, S., Numoto, K., Kikuta, K., Ozaki, T., Lotz, M., Asahara, H. Analysis of microRNAs expressions in chondrosarcoma Journal of Orthopaedic Research 2013 31:1992-1998 DOI:10.1002/jor.22457 PMID:23940002 PMCID:PMC3835201
- Lotz, M., Martel-Pelletier, J., Christiansen, C., Brandi, M. L., Bruyere, O., Chapurlat, R., Collette, J., Cooper, C., Giacovelli, G., Kanis, J. A., Karsdal, M. A., Kraus, V., et al. Value of biomarkers in osteoarthritis: current status and perspectives Annals of the Rheumatic Diseases 2013 72:1756-1763 DOI:10.1136/annrheumdis-2013-203726 PMID:23897772 PMCID:PMC3812859
- Nakahara, H., Hasegawa, A., Otabe, K., Ayabe, F., Matsukawa, T., Onizuka, N., Ito, Y., Ozaki, T., Lotz, M. K., Asahara, H. Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation Arthritis and Rheumatism 2013 65:2081-2089 DOI:10.1002/art.38020 PMID:23686683 PMCID:PMC3840305
- Grogan, S. P., Chung, P. H., Soman, P., Chen, P., Lotz, M. K., Chen, S. C., D'Lima, D. D. Digital micromirror device projection printing system for meniscus tissue engineering Acta Biomaterialia 2013 9:7218-7226 DOI:10.1016/j.actbio.2013.03.020 PMID:23523536 PMCID:PMC3685281
- Carames, B., Kiosses, W. B., Akasaki, Y., Brinson, D. C., Eap, W., Koziol, J., Lotz, M. K. Glucosamine activates autophagy in vitro and in vivo Arthritis and Rheumatism 2013 65:1843-1852 DOI:10.1002/art.37977 PMID:23606170 PMCID:PMC3772083
- van Loosdregt, J., Spreafico, R., Rossetti, M., Prakken, B. J., Lotz, M., Albani, S. Hydroxychloroquine preferentially induces apoptosis of CD45RO(+) effector T cells by inhibiting autophagy: A possible mechanism for therapeutic modulation of T cells Journal of Allergy and Clinical Immunology 2013 131:1443-1446 DOI:10.1016/j.jaci.2013.02.026 PMID:23541328 PMCID:PMC3955204
- Levy, Y. D., Hasegawa, A., Patil, S., Koziol, J. A., Lotz, M. K., D'Lima, D. D. Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis: Correlations with anterior cruciate ligament and cartilage changes Annals of the Rheumatic Diseases 2013 72:271-277 DOI:10.1136/annrheumdis-2012-201730 PMID:22872023 PMCID:PMC3538921
- Grogan, S. P., Duffy, S. F., Pauli, C., Koziol, J. A., Su, A. I., D'Lima, D. D., Lotz, M. K. Zone-specific gene expression patterns in articular cartilage Arthritis and Rheumatism 2013 65:418-428 DOI:10.1002/art.37760 PMID:23124445 PMCID:PMC3558601
- Husa, M., Petursson, F., Lotz, M., Terkeltaub, R., Liu-Bryan, R. C/EBP homologous protein drives pro-catabolic responses in chondrocytes Arthritis Research & Therapy 2013 15:R218 DOI:10.1186/ar4415 PMID:24351550 PMCID:PMC3978428
- Hasegawa, A., Nakahara, H., Kinoshita, M., Asahara, H., Koziol, J., Lotz, M. K. Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis Arthritis Research & Therapy 2013 15:R29 DOI:10.1186/ar4165 PMID:23406989 PMCID:PMC3672799
- Petursson, F., Husa, M., June, R., Lotz, M., Terkeltaub, R., Liu-Bryan, R. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes Arthritis Research & Therapy 2013 15:R77 DOI:10.1186/ar4254 PMID:23883619 PMCID:PMC3979085
- Matsukawa, T., Sakai, T., Yonezawa, T., Hiraiwa, H., Hamada, T., Nakashima, M., Ono, Y., Ishizuka, S., Nakahara, H., Lotz, M. K., Asahara, H., Ishiguro, N. MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritic chondrocytes Arthritis Research & Therapy 2013 15:R28 DOI:10.1186/ar4164 PMID:23406982 PMCID:PMC3672767
- Grogan, S. P., Sovani, S., Pauli, C., Chen, J. F., Hartmann, A., Colwell, C. W., Lotz, M. K., D'Lima, D. D. Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels Tissue Engineering Part A 2012 18:1784-1792 DOI:10.1089/ten.tea.2011.0506 PMID:22536910 PMCID:PMC3432904
- Cui, X. F., Hasegawa, A., Lotz, M., D'Lima, D. Structured three-dimensional co-culture of mesenchymal stem cells with meniscus cells promotes meniscal phenotype without hypertrophy Biotechnology and Bioengineering 2012 109:2369-2380 DOI:10.1002/bit.24495 PMID:22422555 PMCID:PMC3391334
- Cui, X. F., Breitenkamp, K., Lotz, M., D'Lima, D. Synergistic action of fibroblast growth factor-2 and transforming growth factor-beta1 enhances bioprinted human neocartilage formation Biotechnology and Bioengineering 2012 109:2357-2368 DOI:10.1002/bit.24488 PMID:22508498 PMCID:PMC3402696
- Lotz, M., Loeser, R. F. Effects of aging on articular cartilage homeostasis Bone 2012 51:241-248 DOI:10.1016/j.bone.2012.03.023 PMID:22487298 PMCID:PMC3372644
- Pauli, C., Bae, W. C., Lee, M., Lotz, M., Bydder, G. M., D'Lima, D. L., Chung, C. B., Du, J. Ultrashort-echo time MR imaging of the patella with bicomponent analysis: correlation with histopathologic and polarized light microscopic findings Radiology 2012 264:484-493 DOI:10.1148/radiol.12111883 PMID:22653187 PMCID:PMC3401353
- Grogan, S. P., Pauli, C., Chen, P., Du, J., Chung, C. B., Kong, S. D., Colwell, C. W., Lotz, M. K., Jin, S. G., D'Lima, D. D. In situ tissue engineering using magnetically guided three-dimensional cell patterning Tissue Engineering Part C-Methods 2012 18:496-506 DOI:10.1089/ten.tec.2011.0525 PMID:22224660 PMCID:PMC3381294
- Pauli, C., Whiteside, R., Heras, F. L., Nesic, D., Koziol, J., Grogan, S. P., Matyas, J., Pritzker, K. P. H., D'Lima, D. D., Lotz, M. K. Comparison of cartilage histopathology assessment systems on human knee joints at all stages of osteoarthritis development Osteoarthritis and Cartilage 2012 20:476-485 DOI:10.1016/j.joca.2011.12.018 PMID:22353747 PMCID:PMC3348372
- Cui, X. F., Breitenkamp, K., Finn, M. G., Lotz, M., D'Lima, D. D. Direct human cartilage repair using three-dimensional bioprinting technology Tissue Engineering Part A 2012 18:1304-1312 DOI:10.1089/ten.tea.2011.0543 PMID:22394017 PMCID:PMC3360507
- Monemdjou, R., Vasheghani, F., Fahmi, H., Perez, G., Blati, M., Taniguchi, N., Lotz, M., St-Arnaud, R., Pelletier, J. P., Martel-Pelletier, J., Beier, F., Kapoor, M. Association of cartilage-specific deletion of peroxisome proliferator-activated receptor gamma with abnormal endochondral ossification and impaired cartilage growth and development in a murine model Arthritis and Rheumatism 2012 64:1551-1561 DOI:10.1002/art.33490 PMID:22131019 PMCID:PMC3430604
- Carames, B., Hasegawa, A., Taniguchi, N., Miyaki, S., Blanco, F. J., Lotz, M. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis Annals of the Rheumatic Diseases 2012 71:575-581 DOI:10.1136/annrheumdis-2011-200557 PMID:22084394 PMCID:PMC3294168
- Carames, B., Taniguchi, N., Seino, D., Blanco, F. J., D'Lima, D., Lotz, M. Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection Arthritis and Rheumatism 2012 64:1182-1192 DOI:10.1002/art.33444 PMID:22034068 PMCID:PMC3288456
- Chan, E. F., Harjanto, R., Asahara, H., Inoue, N., Masuda, K., Bugbee, W. D., Firestein, G. S., Hosalkar, H. S., Lotz, M. K., Sah, R. L. Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice Orthopedic Clinics of North America 2012 43:173-85 DOI:10.1016/j.ocl.2012.01.005 PMID:22480467 PMCID:PMC3321216
- Hasegawa, A., Otsuki, S., Pauli, C., Miyaki, S., Patil, S., Steklov, N., Kinoshita, M., Koziol, J., D'Lima, D. D., Lotz, M. K. Anterior cruciate ligament changes in the human knee joint in aging and osteoarthritis Arthritis and Rheumatism 2012 64:696-704 DOI:10.1002/art.33417 PMID:22006159 PMCID:PMC3266452
- Lotz, M. Osteoarthritis year 2011 in review: Biology Osteoarthritis and Cartilage 2012 20:192-196 DOI:10.1016/j.joca.2011.11.015 PMID:22179031 PMCID:PMC3288592
- Cui, X., Boland, T., D'Lima, D. D., Lotz, M. K. Thermal inkjet printing in tissue engineering and regenerative medicine Recent Patents on Drug Delivery & Formulation 2012 6:149-155 PMID:22436025 PMCID:PMC3565591
- Taniguchi, N., Carames, B., Hsu, E., Cherqui, S., Kawakami, Y., Lotz, M. Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation Journal of Biological Chemistry 2011 286:41489-41498 DOI:10.1074/jbc.M111.236984 PMID:21890638 PMCID:PMC3308860
- Lotz, M. K., Carames, B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA Nature Reviews Rheumatology 2011 7:579-587 DOI:10.1038/nrrheum.2011.109 PMID:21808292 PMCID:PMC3192496
- Terkeltaub, R., Yang, B., Lotz, M., Liu-Bryan, R. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha Arthritis and Rheumatism 2011 63:1928-1937 DOI:10.1002/art.30333 PMID:21400477 PMCID:PMC3128233
- Itou, J., Taniguchi, N., Oishi, I., Kawakami, H., Lotz, M., Kawakami, Y. HMGB factors are required for posterior digit development through integrating signaling pathway activities Developmental Dynamics 2011 240:1151-1162 DOI:10.1002/dvdy.22598 PMID:21384471 PMCID:PMC3081368
- Pauli, C., Grogan, S. P., Patil, S., Otsuki, S., Hasegawa, A., Koziol, J., Lotz, M. K., D'Lima, D. D. Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis Osteoarthritis and Cartilage 2011 19:1132-1141 DOI:10.1016/j.joca.2011.05.008 PMID:21683797 PMCID:PMC3217905
- Haudenschild, D. R., Chen, J. F., Pang, N. N., Steklov, N., Grogan, S. P., Lotz, M. K., D'Lima, D. D. Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis Journal of Orthopaedic Research 2011 29:20-25 DOI:10.1002/jor.21198 PMID:20602472 PMCID:PMC2976780
- Schelwies, M., Brinson, D., Otsuki, S., Hong, Y. H., Lotz, M. K., Wong, C. H., Hanson, S. R. Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases ChemBioChem 2010 11:2393-2397 DOI:10.1002/cbic.201000401 PMID:20973023 PMCID:PMC3086843
- Lotz, M. K., Otsuki, S., Grogan, S. P., Sah, R., Terkeltaub, R., D'Lima, D. Cartilage cell clusters Arthritis and Rheumatism 2010 62:2206-2218 DOI:10.1002/art.27528 PMID:20506158 PMCID:PMC2921934
- Otsuki, S., Hanson, S. R., Miyaki, S., Grogan, S. P., Kinoshita, M., Asahara, H., Wong, C. H., Lotz, M. K. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways Proceedings of the National Academy of Sciences of the United States of America 2010 107:10202-10207 DOI:10.1073/pnas.0913897107 PMID:20479257 PMCID:PMC2890424
- Oyama, Y., Hashiguchi, T., Taniguchi, N., Tancharoen, S., Uchimura, T., Biswas, K. K., Kawahara, K., Nitanda, T., Umekita, Y., Lotz, M., Maruyama, I. High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy Laboratory Investigation 2010 90:853-866 DOI:10.1038/labinvest.2010.64 PMID:20231821 PMCID:PMC3096665
- Miyaki, S., Sato, T., Inoue, A., Otsuki, S., Ito, Y., Yokoyama, S., Kato, Y., Takemoto, F., Nakasa, T., Yamashita, S., Takada, S., Lotz, M. K., et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis Genes & Development 2010 24:1173-1185 DOI:10.1101/gad.1915510 PMID:20466812 PMCID:PMC2878654
- Carames, B., Taniguchi, N., Otsuki, S., Blanco, F. J., Lotz, M. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis Arthritis and Rheumatism 2010 62:791-801 DOI:10.1002/art.27305 PMID:20187128 PMCID:PMC2838960
- Higashiyama, R., Miyaki, S., Yamashita, S., Yoshitaka, T., Lindman, G., Ito, Y., Sasho, T., Takahashi, K., Lotz, M., Asahara, H. Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis Modern Rheumatology 2010 20:11-17 DOI:10.1007/s10165-009-0224-7 PMID:19784544 PMCID:PMC2818344
- Lotz, M. K. Posttraumatic osteoarthritis: Pathogenesis and pharmacological treatment options Arthritis Research & Therapy 2010 12:211 DOI:10.1186/ar3046 PMID:20602810 PMCID:PMC2911903
- Haudenschild, D. R., Chen, J. F., Pang, N. N., Lotz, M. K., D'Lima, D. D. Rho kinase-dependent activation of SOX9 in chondrocytes Arthritis and Rheumatism 2010 62:191-200 DOI:10.1002/art.25051 PMID:20039424 PMCID:PMC2935318
- Otsuki, S., Grogan, S. P., Miyaki, S., Kinoshita, M., Asahara, H., Lotz, M. K. Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage Journal of Orthopaedic Research 2010 28:96-102 DOI:10.1002/jor.20944 PMID:19603515 PMCID:PMC2905317
- Temple-Wong, M. M., Bae, W. C., Chen, M. Q., Bugbee, W. D., Amiel, D., Coutts, R. D., Lotz, M., Sah, R. L. Biomechanical, structural, and biochemical indices of degenerative and osteoarthritic deterioration of adult human articular cartilage of the femoral condyle Osteoarthritis and Cartilage 2009 17:1469-1476 DOI:10.1016/j.joca.2009.04.017 PMID:19464244 PMCID:PMC2763930
- Taniguchi, N., Carames, B., Kawakami, Y., Amendt, B. A., Komiya, S., Lotz, M. Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway Proceedings of the National Academy of Sciences of the United States of America 2009 106:16817-16822 DOI:10.1073/pnas.0904414106 PMID:19805379 PMCID:PMC2757822
- Ito, T., Yadav, N., Lee, J., Furumatsu, T., Yamashita, S., Yoshida, K., Taniguchi, N., Hashimoto, M., Tsuchiya, M., Ozaki, T., Lotz, M., Bedford, M. T., et al. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification BMC Developmental Biology 2009 9:47 DOI:10.1186/1471-213x-9-47 PMID:19725955 PMCID:PMC2754437
- Miyaki, S., Nakasa, T., Otsuki, S., Grogan, S. P., Higashiyama, R., Inoue, A., Kato, Y., Sato, T., Lotz, M. K., Asahara, H. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses Arthritis and Rheumatism 2009 60:2723-2730 DOI:10.1002/art.24745 PMID:19714579 PMCID:PMC2806094
- Shikhman, A. R., Brinson, D. C., Valbracht, J., Lotz, M. K. Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes Osteoarthritis and Cartilage 2009 17:1022-1028 DOI:10.1016/j.joca.2009.03.004 PMID:19332174 PMCID:PMC2785807
- Taniguchi, N., Carames, B., Ronfani, L., Ulmer, U., Komiya, S., Bianchi, M. E., Lotz, M. Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis Proceedings of the National Academy of Sciences of the United States of America 2009 106:1181-1186 DOI:10.1073/pnas.0806062106 PMID:19139395 PMCID:PMC2633567
- Steklov, N., Srivastava, A., Sung, K. L., Chen, P. C., Lotz, M. K., D'Lima, D. D. Aging-related differences in chondrocyte viscoelastic properties Molecular & Cellular Biomechanics 2009 6:113-119 PMID:19496259
- Garcia-Gonzalez, A., Lotz, M., Ochoa, J. L. Anti-inflammatory activity of superoxide dismutase obtained from Debaryomyces hansenii on type II collagen induced arthritis in rats Revista de Investigacion Clinica 2009 61:212-220 PMID:19736810
- Haudenschild, D. R., Chen, J., Steklov, N., Lotz, M. K., D'Lima, D. D. Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli Molecular & Cellular Biomechanics 2009 6:135-144 PMID:19670824 PMCID:PMC2785729
- Grogan, S. P., Miyaki, S., Asahara, H., D'Lima, D. D., Lotz, M. K. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis Arthritis Research & Therapy 2009 11:R85 DOI:10.1186/ar2719 PMID:19500336 PMCID:PMC2714136
- Mishima, Y., Lotz, M. Chemotaxis of human articular chondrocytes and mesenchymal stem cells Journal of Orthopaedic Research 2008 26:1407-1412 DOI:10.1002/jor.20668 PMID:18464249
- Otsuki, S., Nakajima, M., Lotz, M., Kinoshita, M. Hyaluronic acid and chondroitin sulfate content of osteoarthritic human knee cartilage: Site-specific correlation with weight-bearing force based on femorotibial angle measurement Journal of Orthopaedic Research 2008 26:1194-1198 DOI:10.1002/jor.20571 PMID:18383185
- Grogan, S. P., Olee, T., Hiraoka, K., Lotz, M. K. Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site Arthritis and Rheumatism 2008 58:2754-2763 DOI:10.1002/art.23730 PMID:18759300 PMCID:PMC2786215
- Haudenschild, D. R., Nguyen, B., Chen, J., D'Lima, D. D., Lotz, M. K. Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes Arthritis and Rheumatism 2008 58:2735-2742 DOI:10.1002/art.23797 PMID:18759278 PMCID:PMC2562294
- Wong, B. L., Bae, W. C., Chun, J., Gratz, K. R., Lotz, M., Sah, R. L. Biomechanics of cartilage articulation Arthritis and Rheumatism 2008 58:2065-2074 DOI:10.1002/art.23548 PMID:18576324
- Brown, K. D., Koziol, J. A., Lotz, M. A yoga-based exercise program to reduce the risk of falls in seniors: a pilot and feasibility study Journal of Alternative and Complementary Medicine 2008 14:454-457 DOI:10.1089/acm.2007.0797 PMID:18564950
- Otsuki, S., Brinson, D. C., Creighton, L., Kinoshita, M., Sah, R. L., D'Lima, D., Lotz, M. The effect of glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants Arthritis and Rheumatism 2008 58:1076-1085 DOI:10.1002/art.23381 PMID:18383360
- Haudenschild, D. R., D'Lima, D. D., Lotz, M. K. Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton Biorheology 2008 45:219-228 DOI:10.3233/bir-2008-0499 PMID:18836226
- Otsuki, S., Taniguchi, N., Grogan, S. P., D'Lima, D., Kinoshita, M., Lotz, M. Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage Arthritis Research & Therapy 2008 10:R61 DOI:10.1186/ar2432 PMID:18507859 PMCID:PMC2483452
- Temple, M. M., Bae, W. C., Chen, M. Q., Lotz, M., Amiel, D., Coufts, R. D., Sah, R. L. Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle Osteoarthritis and Cartilage 2007 15:1042-1052 DOI:10.1016/j.joca.2007.03.005 PMID:17468016
- Taniguchi, N., Yoshida, K., Ito, T., Tsuda, M., Mishima, Y., Furumatsu, T., Ronfani, L., Abeyama, K., Kawahara, K., Komiya, S., Maruyama, I., Lotz, M., et al. Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification Molecular and Cellular Biology 2007 27:5650-5663 DOI:10.1128/mcb.00130-07 PMID:17548469
- D'Lima, D., Hermida, J., Hashimoto, S., Colwell, C., Lotz, M. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis Arthritis and Rheumatism 2006 54:1814-1821 DOI:10.1002/art.21874 PMID:16736522
- Grogan, S. P., Olee, T., Johnson, K. A., Terkeltaub, R. A., Lotz, M. K. P127 TGFb3 modulates notch-1 protein expression levels in human articular chondrocytes and mesenchymal stem cells Osteoarthritis and Cartilage 2006 14:S79-S80 DOI:10.1016/S1063-4584(07)60579-2
- Hiraoka, K., Grogan, S., Olee, T., Lotz, M. Mesenchymal progenitor cells in adult human articular cartilage Biorheology 2006 43:447-454 PMID:16912416
- Cecil, D. L., Johnson, K., Rediske, J., Lotz, M., Schmidt, A. M., Terkeltaub, R. Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products Journal of Immunology 2005 175:8296-8302 PMID:16339570
- Daouti, S., Latario, B., Nagulapalli, S., Buxton, F., Uziel-Fusi, S., Chirn, G. W., Bodian, D., Song, C., Labow, M., Lotz, M., Quintavalla, J., Kumar, C. Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis Osteoarthritis and Cartilage 2005 13:508-518 DOI:10.1016/j.joca.2005.02.003 PMID:15922185
- Kinney, R. C., Schwartz, Z., Week, K., Lotz, M. K., Boyan, B. D. Human articular chondrocytes exhibit sexual dimorphism in their responses to 17 beta-estradiol Osteoarthritis and Cartilage 2005 13:330-337 DOI:10.1016/j.joca.2004.12.003 PMID:15780646
- Kawakami, Y., Tsuda, M., Takahashi, S., Taniguchi, N., Esteban, C. R., Zemmyo, M., Furumatsu, T., Lotz, M., Belmonte, J. C. I., Asahara, H. Transcriptional coactivator PGC-1 alpha regulates chondrogenesis via association with Sox9 Proceedings of the National Academy of Sciences of the United States of America 2005 102:2414-2419 DOI:10.1073/pnas.0407510102 PMID:15699338 PMCID:PMC548985
- Shikhman, A. R., Amiel, D., D'Lima, D., Hwang, S. B., Hu, C., Xu, A., Hashimoto, S., Kobayashi, K., Sasho, T., Lotz, M. K. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis Annals of the Rheumatic Diseases 2005 64:89-94 DOI:10.1136/ard.2003.019406 PMID:15608304 PMCID:PMC1755188
- Shikhman, A. R., Brinson, D. C., Lotz, M. K. Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses American Journal of Physiology-Endocrinology and Metabolism 2004 286:E980-E985 DOI:10.1152/ajpendo.00243.2003 PMID:14749204
- Alsalameh, S., Amin, R., Gemba, T., Lotz, M. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage Arthritis and Rheumatism 2004 50:1522-1532 DOI:10.1002/art.20269 PMID:15146422
- Sen, M., Cheng, Y. H., Goldring, M. B., Lotz, M. K., Carson, D. A. WISP3-dependent regulation aggrecan production of type II collagen and in chondrocytes Arthritis and Rheumatism 2004 50:488-497 DOI:10.1002/art.20005 PMID:14872491
- Kuhn, K., D'Lima, D. D., Hashimoto, S., Lotz, M. Cell death in cartilage Osteoarthritis and Cartilage 2004 12:1-16 DOI:10.1016/j.joca.2003.09.015 PMID:14697678
- D'Lima, D. D., Kuhn, K., Lotz, M. K. Detection of apoptosis in cartilage in situ and in isolated chondrocytes Methods in Molecular Medicine 2004 100:275-290 DOI:10.1385/1-59259-810-2:275 PMID:15280601
- Kuhn, K., Shikhman, A. R., Lotz, M. Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in the regulation of human chondrocyte apoptosis Journal of Cellular Physiology 2003 197:379-387 DOI:10.1002/jcp.10372 PMID:14566967
- Seitz, M., Valbracht, J., Quach, J., Lotz, M. Gold sodium thiomalate and chloroquine inhibit cytokine production in monocytic THP-1 cells through distinct transcriptional and posttranslational mechanisms Journal of Clinical Immunology 2003 23:477-484 DOI:10.1023/b:joci.0000010424.41475.17 PMID:15031635
- Zemmyo, M., Meharra, E. J., Kuhn, K., Creighton-Achermann, L., Lotz, M. Accelerated, aging-dependent development of osteoarthritis in alpha 1 integrin-deficient mice Arthritis and Rheumatism 2003 48:2873-2880 DOI:10.1002/art.11246 PMID:14558093
- Kuhn, K., Lotz, M. Mechanisms of sodium nitroprusside-induced death in human chondrocytes Rheumatology International 2003 23:241-247 DOI:10.1007/s00296-003-0299-y PMID:14504917
- D'Lima, D., Lotz, M., Colwell, C. Impact loading: physiological or pathological? Response Osteoarthritis and Cartilage 2002 10:590-590 DOI:10.1053/joca.2002.0804
- Yamada, K., Healey, R., Amiel, D., Lotz, M., Coutts, R. Subchondral bone of the human knee in aging and osteoarthritis Osteoarthritis and Cartilage 2002 10:360-369 DOI:10.1053/joca.2002.0525 PMID:12027537
- Hashimoto, S., Creighton-Achermann, L., Takahashi, K., Amiel, D., Coutts, R. D., Lotz, M. Development and regulation of osteophyte formation during experimental osteoarthritis Osteoarthritis and Cartilage 2002 10:180-187 DOI:10.1053/joca.2001.0505 PMID:11869078
- Gemba, T., Valbracht, J., Alsalameh, S., Lotz, M. Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment Journal of Biological Chemistry 2002 277:907-911 DOI:10.1074/jbc.M109690200 PMID:11677248
- Shikhman, A. R., Brinson, D. C., Valbracht, J., Lotz, M. K. Cytokine regulation of facilitated glucose transport in human articular chondrocytes Journal of Immunology 2001 167:7001-7008 PMID:11739520
- Komuro, H., Olee, T., Kuhn, K., Quach, J., Brinson, D. C., Shikhman, A., Valbracht, J., Creighton-Achermann, L., Lotz, M. The osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand system in cartilage Arthritis and Rheumatism 2001 44:2768-2776 DOI:10.1002/1529-0131(200112)44:12<2768::aid-art464>3.0.co;2-i PMID:11762937
- D'Lima, D. D., Hashimoto, S., Chen, P. C., Colwell, C. W., Lotz, M. K. Human chondrocyte apoptosis in response to mechanical injury Osteoarthritis and Cartilage 2001 9:712-719 DOI:10.1053/joca.2001.0468 PMID:11795990
- Colwell, C. W., D'Lima, D. D., Lotz, M. Association of bone and joint surgeons workshop supplement - Editorial comment Clinical Orthopaedics and Related Research 2001 S2-S5
- Lotz, M. Cytokines in cartilage injury and repair Clinical Orthopaedics and Related Research 2001 391:S108-S115 PMID:11603695
- D'Lima, D. D., Hashimoto, S., Chen, P. C., Colwell, C. W., Lotz, M. K. Impact of mechanical trauma on matrix and cells Clinical Orthopaedics and Related Research 2001 391:S90-S99 PMID:11603728
- Colwell, C. W., D'Lima, D. A., Hoenecke, H. R., Fronek, J., Pulido, P., Morris, B. A., Chung, C., Resnick, D., Lotz, M. In vivo changes after mechanical injury Clinical Orthopaedics and Related Research 2001 391:S116-S123 PMID:11603696
- Kobayashi, K., Mishima, H., Hashimoto, S., Goomer, R. S., Harwood, F. L., Lotz, M., Moriya, H., Amiel, D. Chondrocyte apoptosis and regional differential expression of nitric oxide in the medial meniscus following partial meniscectomy Journal of Orthopaedic Research 2001 19:802-808 DOI:10.1016/s0736-0266(01)00023-7 PMID:11562124
- Liu, J., Shikhman, A. R., Lotz, M. K., Wong, C. H. Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis Chemistry & Biology 2001 8:701-711 DOI:10.1016/s1074-5521(01)00045-x PMID:11451670
- Johnson, K., Hashimoto, S., Lotz, M., Pritzker, K., Terkeltaub, R. Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa American Journal of Pathology 2001 159:149-163 DOI:10.1016/s0002-9440(10)61682-3 PMID:11438463
- Alaaeddine, N., Olee, T., Hashimoto, S., Creighton-Achermann, L., Lotz, M. Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation Arthritis and Rheumatism 2001 44:1633-1643 DOI:10.1002/1529-0131(200107)44:7<1633::aid-art286>3.0.co;2-z PMID:11465714
- Kuhn, K., Lotz, M. Regulation of CD95 (Fas/APO-1)-induced apoptosis in human chondrocytes Arthritis and Rheumatism 2001 44:1644-1653 DOI:10.1002/1529-0131(200107)44:7<1644::aid-art287>3.0.co;2-s PMID:11465715
- Takahashi, K., Hashimoto, S., Kubo, T., Hirasawa, Y., Lotz, M., Amiel, D. Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model Journal of Orthopaedic Research 2001 19:500-503 DOI:10.1016/s0736-0266(00)90024-x PMID:11398866
- Johnson, K., Hashimoto, S., Lotz, M., Pritzker, K., Goding, J., Terkeltaub, R. Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification Arthritis and Rheumatism 2001 44:1071-1081 DOI:10.1002/1529-0131(200105)44:5<1071::aid-anr187>3.0.co;2-3 PMID:11352238
- Shikhman, A. R., Kuhn, K., Alaaeddine, N., Lotz, M. N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes Journal of Immunology 2001 166:5155-5160 PMID:11290798
- Johansen, J. S., Olee, T., Price, P. A., Hashimoto, S., Ochs, R. L., Lotz, M. Regulation of YKL-40 production by human articular chondrocytes Arthritis and Rheumatism 2001 44:826-837 DOI:10.1002/1529-0131(200104)44:4<826::aid-anr139>3.0.co;2-u PMID:11315922
- D'Lima, D. D., Hashimoto, S., Chen, P. C., Lotz, M. K., Colwell, C. W. Cartilage injury induces chondrocyte apoptosis Journal of Bone and Joint Surgery-American Volume 2001 83A:19-21 DOI:10.2106/00004623-200100021-00004 PMID:11685837
- D'Lima, D. D., Hashimoto, S., Chen, P. C., Lotz, M. K., Colwell, C. W. In vitro and in vivo models of cartilage injury Journal of Bone and Joint Surgery-American Volume 2001 83A:22-24
- D'Lima, D. D., Hashimoto, S., Chen, P. C., Lotz, M. K., Colwell, C. W. Prevention of chondrocyte apoptosis Journal of Bone and Joint Surgery-American Volume 2001 83A:25-26 DOI:10.2106/00004623-200100021-00006 PMID:11685840
- Jin, G., Sah, R. L., Li, Y. S., Lotz, M., Shyy, J. Y. J., Chien, S. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes Journal of Orthopaedic Research 2000 18:899-908 DOI:10.1002/jor.1100180608 PMID:11192249
- Takahashi, K., Hashimoto, S., Kubo, T., Hirasawa, Y., Lotz, M., Amiel, D. Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis Journal of Rheumatology 2000 27:1713-1720 PMID:10914857
- Dudler, J., Renggli-Zulliger, N., Busso, N., Lotz, M., So, A. Effect of interleukin 17 on proteoglycan degradation in murine knee joints Annals of the Rheumatic Diseases 2000 59:529-532 DOI:10.1136/ard.59.7.529 PMID:10873962 PMCID:PMC1753181
- Shikhman, A. R., Brinson, D. C., Lotz, M. Profile of glycosaminoglycan-degrading glycosidases and glycoside sulfatases secreted by human articular chondrocytes in homeostasis and inflammation Arthritis and Rheumatism 2000 43:1307-1314 DOI:10.1002/1529-0131(200006)43:6<1307::aid-anr13>3.0.co;2-3 PMID:10857789
- Kuhn, K., Hashimoto, S., Lotz, M. IL-1 beta protects human chondrocytes from CD95-induced apoptosis Journal of Immunology 2000 164:2233-2239 PMID:10657679
- Hashimoto, S., Takahashi, K., Ochs, R. L., Coutts, R. D., Amiel, D., Lotz, M. Nitric oxide production and apoptosis in cells of the meniscus during experimental osteoarthritis Arthritis and Rheumatism 1999 42:2123-2131 DOI:10.1002/1529-0131(199910)42:10<2123::aid-anr12>3.0.co;2-g PMID:10524683
- Kuhn, K., Hashimoto, S., Lotz, M. Cell density modulates apoptosis in human articular chondrocytes Journal of Cellular Physiology 1999 180:439-447 DOI:10.1002/(sici)1097-4652(199909)180:3<439::aid-jcp15>3.0.co;2-d PMID:10430184
- Lotz, M., Hashimoto, S., Kuhn, K. Mechanisms of chondrocyte apoptosis Osteoarthritis and Cartilage 1999 7:389-391 DOI:10.1053/joca.1998.0220 PMID:10419776
- Lotz, M. The role of nitric oxide in articular cartilage damage Rheumatic Disease Clinics of North America 1999 25:269-282 DOI:10.1016/s0889-857x(05)70067-3 PMID:10356417
- Olee, T., Hashimoto, S., Quach, J., Lotz, M. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses Journal of Immunology 1999 162:1096-1100 PMID:9916738
- Terkeltaub, R., Lotz, M., Johnson, K., Deng, D. L., Hashimoto, S., Goldring, M. B., Burton, D., Deftos, L. J. Parathyroid hormone-related protein is abundant in osteoarthritic cartilage, and the parathyroid hormone-related protein 1-173 isoform is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate Arthritis and Rheumatism 1998 41:2152-2164 DOI:10.1002/1529-0131(199812)41:12<2152::aid-art10>3.3.co;2-o PMID:9870872
- Geng, Y., Zhou, L., Thompson, W. J., Lotz, M. Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes Journal of Biological Chemistry 1998 273:27484-27491 DOI:10.1074/jbc.273.42.27484 PMID:9765278
- Shalom-Barak, T., Quach, J., Lotz, M. Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappa B Journal of Biological Chemistry 1998 273:27467-27473 DOI:10.1074/jbc.273.42.27467 PMID:9765276
- Hashimoto, S., Ochs, R. L., Komiya, S., Lotz, M. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis Arthritis and Rheumatism 1998 41:1632-1638 DOI:10.1002/1529-0131(199809)41:9<1632::aid-art14>3.0.co;2-a PMID:9751096
- Hashimoto, S., Ochs, R. L., Rosen, F., Quach, J., McCabe, G., Solan, J., Seegmiller, J. E., Terkeltaub, R., Lotz, M. Chondrocyte-derived apoptotic bodies and calcification of articular cartilage Proceedings of the National Academy of Sciences of the United States of America 1998 95:3094-3099 DOI:10.1073/pnas.95.6.3094 PMID:9501221
- Hashimoto, S., Takahashi, K., Amiel, D., Coutts, R. D., Lotz, M. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis Arthritis and Rheumatism 1998 41:1266-1274 DOI:10.1002/1529-0131(199807)41:7<1266::aid-art18>3.0.co;2-y PMID:9663485
- vonKempis, J., Schwarz, H., Lotz, M. Differentiation-dependent and stimulus-specific expression of ILA, the human 4-1BB-homologue, in cells of mesenchymal origin Osteoarthritis and Cartilage 1997 5:394-406 PMID:9536288
- Shiraishi, A., Dudler, J., Lotz, M. The role of IFN regulatory factor-1 in synovitis and nitric oxide production Journal of Immunology 1997 159:3549-3554 PMID:9317154
- Rosen, F., McCabe, G., Quach, J., Solan, J., Terkeltaub, R., Seegmiller, J. E., Lotz, M. Differential effects of aging on human chondrocyte responses to transforming growth factor beta - increased pyrophosphate production and decreased cell proliferation Arthritis and Rheumatism 1997 40:1275-1281 DOI:10.1002/1529-0131(199707)40:7<1275::aid-art12>3.0.co;2-h PMID:9214428
- Schwarz, H., Arden, K., Lotz, M. CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies Biochemical and Biophysical Research Communications 1997 235:699-703 DOI:10.1006/bbrc.1997.6870 PMID:9207223
- Cai, J., Zheng, T., Lotz, M., Zhang, Y., Masood, R., Gill, P. Glucocorticoids induce Kaposi's sarcoma cell proliferation through the regulation of transforming growth factor-beta Blood 1997 89:1491-1500 PMID:9057628
- Zvaifler, N. J., Tsai, V., Alsalameh, S., vonKempis, J., Firestein, G. S., Lotz, M. Pannocytes: Distinctive cells found in rheumatoid arthritis articular cartilage erosions American Journal of Pathology 1997 150:1125-1138 PMID:9060847 PMCID:PMC1857892
- Hashimoto, S., Setareh, M., Ochs, R. L., Lotz, M. Fas/Fas ligand expression and induction of apoptosis in chondrocytes Arthritis and Rheumatism 1997 40:1749-1755 DOI:10.1002/art.1780401004 PMID:9336406
- Geng, Y., Valbracht, J., Lotz, M. Selective activation of the mitogen-activated protein kinase subgroups C-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes Journal of Clinical Investigation 1996 98:2425-2430 DOI:10.1172/jci119056 PMID:8941662
- Sato, Y., Roman, M., Tighe, H., Lee, D., Corr, M., Nguyen, M. D., Silverman, G. J., Lotz, M., Carson, D. A., Raz, E. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization Science 1996 273:352-354 DOI:10.1126/science.273.5273.352 PMID:8662521
- Lotz, M., Setareh, M., vonKempis, J., Schwarz, H. The nerve growth factor/tumor necrosis factor receptor family Journal of Leukocyte Biology 1996 60:1-7 PMID:8699112
- Schwarz, H., Blanco, F. J., vonKempis, J., Valbracht, J., Lotz, M. ILA, a member of the human nerve growth factor tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival Blood 1996 87:2839-2845 PMID:8639902
- Maier, R., Wisniewski, H. G., Vilcek, J., Lotz, M. TSG-6 expression in human articular chondrocytes - possible implications in joint inflammation and cartilage degradation Arthritis and Rheumatism 1996 39:552-559 DOI:10.1002/art.1780390403 PMID:8630102
- Setareh, M., Schwarz, H., Lotz, M. A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGf/TNF receptor family Gene 1995 164:311-315 DOI:10.1016/0378-1119(95)00349-b PMID:7590349
- Lotz, M., Rosen, F., McCabe, G., Quach, J., Blanco, F., Dudler, J., Solan, J., Goding, J., Seegmiller, J. E., Terkeltaub, R. Interleukin-1-beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes Proceedings of the National Academy of Sciences of the United States of America 1995 92:10364-10368 DOI:10.1073/pnas.92.22.10364 PMID:7479785
- Raz, E., Dudler, J., Lotz, M., Baird, S. M., Berry, C. C., Eisenberg, R. A., Carson, D. A. Modulation of disease-activity in murine systemic lupus-erythematosus by cytokine gene delivery Lupus 1995 4:286-292 DOI:10.1177/096120339500400409 PMID:8528225
- Geng, Y., Blanco, F. J., Cornelisson, M., Lotz, M. Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes Journal of Immunology 1995 155:796-801 PMID:7608556
- Guerne, P. A., Blanco, F., Kaelin, A., Desgeorges, A., Lotz, M. Growth-factor responsiveness of human articular chondrocytes in aging and development Arthritis and Rheumatism 1995 38:960-968 DOI:10.1002/art.1780380712 PMID:7612045
- Geng, Y., Lotz, M. Increased intracellular ca2+ selectively suppresses il-1-induced no production by reducing inos messenger-rna stability Journal of Cell Biology 1995 129:1651-1657 DOI:10.1083/jcb.129.6.1651 PMID:7540612
- Geng, Y., Maier, R., Lotz, M. Tyrosine kinases are involved with the expression of inducible nitric-oxide synthase in human articular chondrocytes Journal of Cellular Physiology 1995 163:545-554 DOI:10.1002/jcp.1041630315 PMID:7539812
- Blanco, F. J., Lotz, M. IL-1-induced nitric-oxide inhibits chondrocyte proliferation via PGE2 Experimental Cell Research 1995 218:319-325 DOI:10.1006/excr.1995.1161 PMID:7537695
- Blanco, F. J., Geng, Y., Lotz, M. Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric-oxide synthase expression Journal of Immunology 1995 154:4018-4026 PMID:7535818
- Schwarz, H., Valbracht, J., Tuckwell, J., Vonkempis, J., Lotz, M. Ila, the human 4-1bb homolog, is inducible in lymphoid and other cell lineages Blood 1995 85:1043-1052 PMID:7849293
- Lotz, M., Blanco, F. J., Vonkempis, J., Dudler, J., Maier, R., Villiger, P. M., Geng, Y. Cytokine regulation of chondrocyte functions Journal of Rheumatology 1995 22:104-108
- Blanco, F. J., Ochs, R. L., Schwarz, H., Lotz, M. Chondrocyte apoptosis induced by nitric-oxide American Journal of Pathology 1995 146:75-85 PMID:7856740 PMCID:PMC1870754
- Schwarz, H., Blanco, F. J., Lotz, M. Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte-proliferation and induces apoptosis Journal of Neuroimmunology 1994 55:107-115 DOI:10.1016/0165-5728(94)90152-x PMID:7962480
- Maier, R., Bilbe, G., Rediske, J., Lotz, M. Inducible nitric-oxide synthase from human articular chondrocytes - cDNA cloning and analysis of messenger-RNA expression Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology 1994 1208:145-150 DOI:10.1016/0167-4838(94)90171-6
- Zuraw, B. L., Sugimoto, S., Parsons, C. L., Hugli, T., Lotz, M., Koziol, J. Activation of urinary kallikrein in patients with interstitial cystitis Journal of Urology 1994 152:874-878 PMID:8051740
- Lotz, M., Villiger, P., Hugli, T., Koziol, J., Zuraw, B. L. Interleukin-6 and interstitial cystitis Journal of Urology 1994 152:869-873 PMID:8051739
- Geng, Y., Gulbins, E., Altman, A., Lotz, M. Monocyte deactivation by interleukin-10 via inhibition of tyrosine kinase-activity and the Ras signaling pathway Proceedings of the National Academy of Sciences of the United States of America 1994 91:8602-8606 DOI:10.1073/pnas.91.18.8602 PMID:8078929
- Broor, S., Kusari, A. B., Zhang, B. P., Seth, P., Richman, D. D., Carson, D. A., Wachsman, W., Lotz, M. Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 1994 7:647-654 PMID:8207643
- Woods, V. L., Schreck, P. J., Gesink, D. S., Pacheco, H. O., Amiel, D., Akeson, W. H., Lotz, M. Integrin expression by human articular chondrocytes Arthritis and Rheumatism 1994 37:537-544 DOI:10.1002/art.1780370414 PMID:8147931
- Schwarz, H., Villiger, P. M., Vonkempis, J., Lotz, M. Neuropeptide-Y is an inducible gene in the human immune-system Journal of Neuroimmunology 1994 51:53-61 DOI:10.1016/0165-5728(94)90128-7 PMID:8157736
- Guerne, P. A., Sublet, A., Lotz, M. Growth-factor responsiveness of human articular chondrocytes - distinct profiles in primary chondrocytes, subcultured chondrocytes, and fibroblasts Journal of Cellular Physiology 1994 158:476-484 DOI:10.1002/jcp.1041580312 PMID:8126071
- Lotz, M., Ranheim, E., Kipps, T. J. Transforming growth-factor-beta as endogenous growth inhibitor of chronic lymphocytic-leukemia B-cells Journal of Experimental Medicine 1994 179:999-1004 DOI:10.1084/jem.179.3.999 PMID:8113691
- Lotz, M., Clarklewis, I., Ganu, V. HIV-1 transactivator protein Tat induces proliferation and TGF-beta expression in human articular chondrocytes Journal of Cell Biology 1994 124:365-371 DOI:10.1083/jcb.124.3.365 PMID:8294518
- Geng, Y., Zhang, B. P., Lotz, M. Protein-tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes Journal of Immunology 1993 151:6692-6700 PMID:8258685
- Schwarz, H., Tuckwell, J., Lotz, M. A receptor-induced by lymphocyte-activation (ILA) - a new member of the human nerve-growth-factor tumor-necrosis-factor receptor family Gene 1993 134:295-298 DOI:10.1016/0378-1119(93)90110-o PMID:8262389
- Wisniewski, H. G., Maier, R., Lotz, M., Lee, S., Klampfer, L., Lee, T. H., Vilcek, J. TSG-6 - a TNF-, IL-1-, and LPS-inducible secreted glycoprotein associated with arthritis Journal of Immunology 1993 151:6593-6601 PMID:8245487
- Maier, R., Ganu, V., Lotz, M. Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases Journal of Biological Chemistry 1993 268:21527-21532 PMID:8408003
- Villiger, P. M., Kusari, A. B., Tendijke, P., Lotz, M. Il-1-beta and il-6 selectively induce transforming growth-factor-beta isoforms in human articular chondrocytes Journal of Immunology 1993 151:3337-3344 PMID:8376781
- Gross, V., Zhang, B. P., Geng, Y., Villiger, P. M., Lotz, M. Regulation of interleukin-6 (IL-6) expression - evidence for a tissue-specific role of protein-kinase-C Journal of Clinical Immunology 1993 13:310-320 DOI:10.1007/bf00920239 PMID:8245177
- Gross, V., Villiger, P. M., Zhang, B. P., Lotz, M. Retinoic acid inhibits interleukin-1 induced cytokine synthesis in human monocytes Journal of Leukocyte Biology 1993 54:125-132 PMID:8360592
- Lotz, M., Seth, P. TGF beta and HIV infection Annals of the New York Academy of Sciences 1993 685:501-511 DOI:10.1111/j.1749-6632.1993.tb35912.x PMID:7689810
- Raz, E., Watanabe, A., Baird, S. M., Eisenberg, R. A., Parr, T. B., Lotz, M., Kipps, T. J., Carson, D. A. Systemic immunological effects of cytokine genes injected into skeletal-muscle Proceedings of the National Academy of Sciences of the United States of America 1993 90:4523-4527 DOI:10.1073/pnas.90.10.4523 PMID:8506293
- Delcayre, A. X., Lotz, M., Lernhardt, W. Inhibition of Epstein-Barr virus-mediated capping of CD21 CR-2 by alpha-interferon (IFN-alpha) - immediate antiviral activity of IFN-alpha during the early phase of infection Journal of Virology 1993 67:2918-2921 PMID:8386282 PMCID:PMC237619
- Machold, K. P., Carson, D. A., Lotz, M. Transforming growth-factor-beta (TGF-beta) inhibition of Epstein-Barr-virus (EBV)-4 and interleukin-4 (IL-4)-induced immunoglobulin production in human B-lymphocytes Journal of Clinical Immunology 1993 13:219-227 DOI:10.1007/bf00919975 PMID:8391546
- Villiger, P. M., Geng, Y., Lotz, M. Induction of cytokine expression by leukemia inhibitory factor Journal of Clinical Investigation 1993 91:1575-1581 DOI:10.1172/jci116363 PMID:8473500
- Lotz, M. Interleukin-6 Cancer Investigation 1993 11:732-742 DOI:10.3109/07357909309046948 PMID:8221206
- Villiger, P. M., Fey, M. F., Lotz, M., Tobler, A. IgG2 and igG4 subclass deficiency and Evans syndrome in an adult patient Journal of Allergy and Clinical Immunology 1992 90:693-694 DOI:10.1016/0091-6749(92)90147-t PMID:1401651
- Lotz, M., Moats, T., Villiger, P. M. Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis Journal of Clinical Investigation 1992 90:888-896 DOI:10.1172/jci115964 PMID:1522240
- Villiger, P. M., Terkeltaub, R., Lotz, M. Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid Journal of Clinical Investigation 1992 90:488-496 DOI:10.1172/jci115885 PMID:1365641 PMCID:PMC443125
- Villiger, P. M., Terkeltaub, R., Lotz, M. Production of monocyte chemoattractant protein-1 by inflamed synovial tissue and cultured synoviocytes Journal of Immunology 1992 149:722-727 PMID:1624809
- Mandler, R. N., Kerrigan, D. P., Smart, J., Kuis, W., Villiger, P., Lotz, M. Castlemans disease in POEMS syndrome with elevated interleukin-6 Cancer 1992 69:2697-2703 DOI:10.1002/1097-0142(19920601)69:11<2697::aid-cncr2820691112>3.0.co;2-3 PMID:1571900
- Broide, D. H., Lotz, M., Cuomo, A. J., Coburn, D. A., Federman, E. C., Wasserman, S. I. Cytokines in symptomatic asthma airways Journal of Allergy and Clinical Immunology 1992 89:958-967 DOI:10.1016/0091-6749(92)90218-q PMID:1374772
- Villiger, P. M., Lotz, M. Differential expression of tgf-beta isoforms by human articular chondrocytes in response to growth-factors Journal of Cellular Physiology 1992 151:318-325 DOI:10.1002/jcp.1041510213 PMID:1572906
- Lotz, M., Terkeltaub, R., Villiger, P. M. Cartilage and joint inflammation - regulation of IL-8 expression by human articular chondrocytes Journal of Immunology 1992 148:466-473 PMID:1729366
- Villiger, P. M., Lotz, M. Expression of prepro-enkephalin in human articular chondrocytes is linked to cell-proliferation EMBO Journal 1992 11:135-143 PMID:1310929 PMCID:PMC556434
- Maisel, A. S., Murray, D., Lotz, M., Rearden, A., Irwin, M., Michel, M. C. Propranolol treatment affects parameters of human immunity Immunopharmacology 1991 22:157-164 DOI:10.1016/0162-3109(91)90040-6 PMID:1774156
- Guerne, P. A., Lotz, M. Interleukin-6 and transforming growth-factor-beta synergistically stimulate chondrosarcoma cell-proliferation Journal of Cellular Physiology 1991 149:117-124 DOI:10.1002/jcp.1041490115 PMID:1939340
- Kuis, W., Villiger, P. M., Leser, H. G., Lotz, M. Differential processing of proenkephalin-A by human peripheral-blood monocytes and T lymphocytes Journal of Clinical Investigation 1991 88:817-824 DOI:10.1172/jci115382 PMID:1885771
- Delcayre, A. X., Salas, F., Mathur, S., Kovats, K., Lotz, M., Lernhardt, W. Epstein-Barr-virus complement C3d receptor is an interferon-alpha receptor EMBO Journal 1991 10:919-926 PMID:1849076 PMCID:PMC452735
- Kekow, J., Gross, W. L., Carson, D. A., Lotz, M. Modulation of immunocompetent cells in synovial-fluids by TGF-beta Immunitat und Infektion 1991 19:60-61 PMID:1677345
- Kekow, J., Wachsman, W., McCutchan, J. A., Gross, W. L., Zachariah, M., Carson, D. A., Lotz, M. Transforming growth-factor-beta and suppression of humoral immune-responses in HIV-infection Journal of Clinical Investigation 1991 87:1010-1016 DOI:10.1172/jci115059 PMID:1999481
- Lotz, M., Guerne, P. A. Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA) Journal of Biological Chemistry 1991 266:2017-2020 PMID:1846608
- Villiger, P. M., Cronin, M. T., Amenomori, T., Wachsman, W., Lotz, M. IL-6 production by human T lymphocytes - expression in HTLV-1-infected but not in normal T-cells Journal of Immunology 1991 146:550-559 PMID:1987276
- Carrera, C. J., Terai, C., Lotz, M., Curd, J. G., Piro, L. D., Beutler, E., Carson, D. A. Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy Journal of Clinical Investigation 1990 86:1480-1488 DOI:10.1172/jci114865 PMID:1700795 PMCID:PMC296893
- Kekow, J., Wachsman, W., McCutchan, J. A., Cronin, M., Carson, D. A., Lotz, M. Transforming growth-factor-beta and noncytopathic mechanisms of immunodeficiency in human-immunodeficiency-virus infection Proceedings of the National Academy of Sciences of the United States of America 1990 87:8321-8325 DOI:10.1073/pnas.87.21.8321 PMID:1700428
- Tighe, H., Silverman, G. J., Kozin, F., Tucker, R., Gulizia, R., Peebles, C., Lotz, M., Rhodes, G., Machold, K., Mosier, D. E., Carson, D. A. Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients European Journal of Immunology 1990 20:1843-1848 DOI:10.1002/eji.1830200832 PMID:2209691
- Zuraw, B. L., Lotz, M. Regulation of the hepatic synthesis of C1 inhibitor by the hepatocyte stimulating factors interleukin-6 and interferon-gamma Journal of Biological Chemistry 1990 265:12664-12670 PMID:1695634
- Lotz, M., Kekow, J., Carson, D. A. Transforming growth-factor-beta and cellular immune-responses in synovial-fluids Journal of Immunology 1990 144:4189-4194 PMID:2187926
- Guerne, P. A., Carson, D. A., Lotz, M. IL-6 production by human articular chondrocytes - modulation of its synthesis by cytokines, growth-factors, and hormones in vitro Journal of Immunology 1990 144:499-505 PMID:2104896
- Guerne, P. A., Terkeltaub, R., Zuraw, B., Lotz, M. Inflammatory microcrystals stimulate interleukin-6 production and secretion by human-monocytes and synoviocytes Arthritis and Rheumatism 1989 32:1443-1452 DOI:10.1002/anr.1780321114 PMID:2554932
- Lotz, M., Zuraw, B. L., Carson, D. A., Jirik, F. R. Hepatocytes produce interleukin-6 Annals of the New York Academy of Sciences 1989 557:509-511 DOI:10.1111/j.1749-6632.1989.tb24048.x
- Podor, T. J., Jirik, F. R., Loskutoff, D. J., Carson, D. A., Lotz, M. Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6 Annals of the New York Academy of Sciences 1989 557:374-387 DOI:10.1111/j.1749-6632.1989.tb24030.x PMID:2660697
- Guerne, P. A., Vaughan, J. H., Carson, D. A., Terkeltaub, B., Lotz, M. Interleukin-6 (IL-6) and joint tissues Annals of the New York Academy of Sciences 1989 557:558-561 DOI:10.1111/j.1749-6632.1989.tb24065.x
- Guerne, P. A., Zuraw, B. L., Vaughan, J. H., Carson, D. A., Lotz, M. Synovium as a source of interleukin 6 in vitro - contribution to local and systemic manifestations of arthritis Journal of Clinical Investigation 1989 83:585-592 DOI:10.1172/jci113921 PMID:2464001
- Jirik, F. R., Podor, T. J., Hirano, T., Kishimoto, T., Loskutoff, D. J., Carson, D. A., Lotz, M. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells Journal of Immunology 1989 142:144-147 PMID:2783321
- Lotz, M., Roudier, J. Epstein-Barr virus and rheumatoid-arthritis - cellular and molecular aspects Rheumatology International 1989 9:147-152 PMID:2481874
- Lotz, M., Vaughan, J. H., Carson, D. A. Effect of neuropeptides on production of inflammatory cytokines by human-monocytes Science 1988 241:1218-1221 DOI:10.1126/science.2457950 PMID:2457950
- Lotz, M., Jirik, F., Kabouridis, P., Tsoukas, C., Hirano, T., Kishimoto, T., Carson, D. A. B-cell stimulating factor-2/interleukin-6 is a costimulant for human thymocytes and lymphocytes-T Journal of Experimental Medicine 1988 167:1253-1258 DOI:10.1084/jem.167.3.1253 PMID:3127525
- Lotz, M., Zuraw, B. L. Interferon-gamma is a major regulator of C1-inhibitor synthesis by human-blood monocytes Journal of Immunology 1987 139:3382-3387 PMID:3119706
- Kurki, P., Lotz, M., Ogata, K., Tan, E. M. Proliferating cell nuclear antigen (PCNA)/cyclin in activated human T lymphocytes Journal of Immunology 1987 138:4114-4120 PMID:2884260
- Lotz, M., Carson, D. A., Vaughan, J. H. Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis Science 1987 235:893-895 DOI:10.1126/science.2433770 PMID:2433770
- Lotz, M., Tsoukas, C. D., Curd, J. G., Carson, D. A., Vaughan, J. H. Effects of recombinant human interferons on rheumatoid-arthritis lymphocytes-B activated by Epstein-Barr-virus Journal of Rheumatology 1987 14:42-45 PMID:3033238
- Lotz, M., Tsoukas, C. D., Robinson, C. A., Dinarello, C. A., Carson, D. A., Vaughan, J. H. Basis for defective responses of rheumatoid-arthritis synovial-fluid lymphocytes to anti-CD3 (T3) antibodies Journal of Clinical Investigation 1986 78:713-721 DOI:10.1172/jci112631 PMID:3091636
- Valentine, M., Lotz, M., Dinarello, C. A., Carson, D. A., Vaughan, J. H. Lymphoblastoid B-cell lines produce an interleukin-1-like activity that can be serologically distinct from macrophage interleukin-1 Lymphokine Research 1986 5:173-183 PMID:3018386
- Lotz, M., Tsoukas, C. D., Fong, S., Dinarello, C. A., Carson, D. A., Vaughan, J. H. Release of lymphokines after Epstein-Barr virus-infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in normal humans Journal of Immunology 1986 136:3636-3642 PMID:3009608
- Lotz, M., Tsoukas, C. D., Fong, S., Dinarello, C. A., Carson, D. A., Vaughan, J. H. Release of lymphokines after infection with Epstein-Barr-virus in vitro .2. A monocyte-dependent inhibitor of interleukin-1 down-regulates the production of interleukin-2 and interferon-gamma in rheumatoid-arthritis Journal of Immunology 1986 136:3643-3648 PMID:3009609
- Tsoukas, C. D., Landgraf, B., Bentin, J., Valentine, M., Lotz, M., Vaughan, J. H., Carson, D. A. Activation of resting lymphocytes-T by anti-CD3 (T3) antibodies in the absence of monocytes Journal of Immunology 1985 135:1719-1723 PMID:3926881
- Fox, R. I., Lotz, M., Rhodes, G., Vaughan, J. H. Epstein-Barr virus in rheumatoid-arthritis Clinics in Rheumatic Diseases 1985 11:665-688 PMID:3000687
- Lotz, M., Tsoukas, C. D., Fong, S., Carson, D. A., Vaughan, J. H. Regulation of Epstein-Barr virus-infection by recombinant interferons - selected sensitivity to interferon-gamma European Journal of Immunology 1985 15:520-525 DOI:10.1002/eji.1830150518 PMID:2581792
- Tsoukas, C. D., Valentine, M., Lotz, M., Vaughan, J. H., Carson, D. A. The role of the T3 molecular-complex on human lymphocyte-T mediated cyto-toxicity Advances in Experimental Medicine and Biology 1985 184:365-385 PMID:2931002
- Tsoukas, C. D., Lambris, J., Lotz, M., Valentine, M. A., Vaughan, J. H., Carson, D. A. Lymphocyte mitogenesis induced by monoclonal-antibodies to the T3-complex - differential modulation by human-IgG Cellular Immunology 1984 89:66-74 DOI:10.1016/0008-8749(84)90198-9 PMID:6207944
- Tsoukas, C. D., Valentine, M., Lotz, M., Vaughan, J. H., Carson, D. A. The role of the T3 molecular-complex in antigen recognition and subsequent activation events Immunology Today 1984 5:311-313 DOI:10.1016/0167-5699(84)90121-x PMID:25290752
