academic article

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• Nogueira-Recalde, U., Lorenzo-Gomez, I., Blanco, F. J., Loza, M. I., Grassi, D., Shirinsky, V., Shirinsky, I., Lotz, M., Robbins, P. D., Dominguez, E., Carames, B. Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy Ebiomedicine  2019 45:588-605  DOI:10.1016/j.ebiom.2019.06.049  PMID:31285188  PMCID:PMC6642320
• Otsuki, S., Alvarez-Garcia, O., Lotz, M. K., Neo, M. Role of heparan sulfate 6-0 endosulfatases in intervertebral disc homeostasis Histology and Histopathology  2019 34:1051-1060  DOI:10.14670/hh-18-107  PMID:30924907
• Wyseure, T., Yang, T., Zhou, J. Y., Cooke, E. J., Wanko, B., Olmer, M., Agashe, R., Morodomi, Y., Behrendt, N., Lotz, M., Morser, J., von Drygalski, A., et al. TAFI deficiency causes maladaptive vascular remodeling after hemophilic joint bleeding JCI Insight  2019 4  DOI:10.1172/jci.insight.128379  PMID:31465300
• Ishitobi, H., Sanada, Y., Kato, Y., Ikuta, Y., Shibata, S., Yamasaki, S., Lotz, M. K., Matsubara, K., Miyaki, S., Adachi, N. Carnosic acid attenuates cartilage degeneration through induction of heme oxygenase-1 in human articular chondrocytes European Journal of Pharmacology  2018 830:1-8  DOI:10.1016/j.ejphar.2018.04.018  PMID:29678719
• Miyaki, S., Lotz, M. K. Extracellular vesicles in cartilage homeostasis and osteoarthritis Current Opinion in Rheumatology  2018 30:129-135  DOI:10.1097/bor.0000000000000454  PMID:29035932  PMCID:PMC5810945
• Alvarez-Garcia, O., Matsuzaki, T., Olmer, M., Miyata, K., Mokuda, S., Sakai, D., Masuda, K., Asahara, H., Lotz, M. K. FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration Aging Cell  2018 17  DOI:10.1111/acel.12800  PMID:29963746  PMCID:PMC6156454
• Matsuzaki, T., Alvarez-Garcia, O., Mokuda, S., Nagira, K., Olmer, M., Gamini, R., Miyata, K., Akasaki, Y., Su, A. I., Asahara, H., Lotz, M. K. FoxO transcription factors modulate autophagy and proteoglycan 4 in cartilage homeostasis and osteoarthritis Science Translational Medicine  2018 10:eaan0746  DOI:10.1126/scitranslmed.aan0746  PMID:29444976
• Grogan, S. P., Duffy, S. F., Pauli, C., Lotz, M. K., D'Lima, D. D. Gene expression profiles of the meniscus avascular phenotype: A guide for meniscus tissue engineering Journal of Orthopaedic Research  2018 36:1947-1958  DOI:10.1002/jor.23864  PMID:29411909
• Taniguchi, N., Kawakami, Y., Maruyama, I., Lotz, M. HMGB proteins and arthritis Human Cell  2018 31:1-9  DOI:10.1007/s13577-017-0182-x  PMID:28916968
• Lee, D., Taniguchi, N., Sato, K., Choijookhuu, N., Hishikawa, Y., Kataoka, H., Morinaga, H., Lotz, M., Chosa, E. HMGB2 is a novel adipogenic factor that regulates ectopic fat infiltration in skeletal muscles Scientific Reports  2018 8  DOI:10.1038/s41598-018-28023-7  PMID:29942000  PMCID:PMC6018498
• Fisch, K. M., Gamini, R., Alvarez-Garcia, O., Akagi, R., Saito, M., Muramatsu, Y., Sasho, T., Koziol, J. A., Su, A. I., Lotz, M. K. Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis Osteoarthritis Cartilage  2018 1531-1538  DOI:10.1016/j.joca.2018.07.012  PMID:30081074
• Serrano, R. L., Chen, L. Y., Lotz, M. K., Liu-Bryan, Ru, Terkeltaub, R. Impaired proteasomal function in human osteoarthritic chondrocytes can contribute to decreased levels of SOX9 and aggrecan Arthritis & Rheumatology  2018 70:1030-1041  DOI:10.1002/art.40456  PMID:29457374  PMCID:PMC6019618
• Chen, L. Y., Lotz, M., Terkeltaub, R., Liu-Bryan, R. Modulation of matrix metabolism by ATP-citrate lyase in articular chondrocytes Journal of Biological Chemistry  2018 293:12259-12270  DOI:10.1074/jbc.RA118.002261  PMID:29929979  PMCID:PMC6078460
• Kumar, P., Yao, L. J., Saidin, S., Paleja, B., Van Loosdregt, J., Chua, C., Arkachaisri, T., Consolaro, A., Gattorno, M., Martini, A., Pischel, K. D., Williams, G. W., et al. Molecular mechanisms of autophagic memory in pathogenic T cells in human arthritis Journal of Autoimmunity  2018 94:90-98  DOI:10.1016/j.jaut.2018.07.014  PMID:30077426
• Lee, K. I., Olmer, M., Baek, J., D'Lima, D. D., Lotz, M. K. Platelet-derived growth factor-coated decellularized meniscus scaffold for integrative healing of meniscus tears Acta Biomaterialia  2018 76:126-134  DOI:10.1016/j.actbio.2018.06.021  PMID:29908335  PMCID:PMC6090559
• Alvarez-Garcia, O., Matsuzaki, T., Olmer, M., Masuda, K., Lotz, M. K. Age-related reduction in the expression of FOXO transcription factors and correlations with intervertebral disc degeneration Journal of Orthopaedic Research  2017 35:2682-2691  DOI:10.1002/jor.23583  PMID:28430387  PMCID:PMC5650945
• Meckes, J. K., Carames, B., Olmer, M., Kiosses, W. B., Grogan, S. P., Lotz, M. K., D'Lima, D. D. Compromised autophagy precedes meniscus degeneration and cartilage damage in mice Osteoarthritis and Cartilage  2017 25:1880-1889  DOI:10.1016/j.joca.2017.07.023  PMID:28801209  PMCID:PMC5650923
• Akagi, R., Akatsu, Y., Fisch, K. M., Alvarez-Garcia, O., Teramura, T., Muramatsu, Y., Saito, M., Sasho, T., Su, A. I., Lotz, M. K. Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes Osteoarthritis and Cartilage  2017 25:943-951  DOI:10.1016/j.joca.2016.11.007  PMID:27884645  PMCID:PMC5438901
• Yu, X., Kawakami, H., Tahara, N., Olmer, M., Hayashi, S., Akiyama, R., Bagchi, A., Lotz, M., Kawakami, Y. Expression of Noggin and Gremlin1 and its implications in fine-tuning BMP activities in mouse cartilage tissues Journal of Orthopaedic Research  2017 35:1671-1682  DOI:10.1002/jor.23463  PMID:27769098
• Peeters, J. G. C., de Graeff, N., Lotz, M., Albani, S., de Roock, S., van Loosdregt, J. Increased autophagy contributes to the inflammatory phenotype of juvenile idiopathic arthritis synovial fluid T cells Rheumatology  2017 56:1694-1699  DOI:10.1093/rheumatology/kex227  PMID:28957547
• Alvarez-Garcia, O., Matsuzaki, T., Olmer, M., Plate, L., Kelly, J. W., Lotz, M. K. Regulated in development and DNA Damage response 1 deficiency impairs autophagy and mitochondrial biogenesis in articular cartilage and increases the severity of experimental osteoarthritis Arthritis & Rheumatology  2017 69:1418-1428  DOI:10.1002/art.40104  PMID:28334504  PMCID:PMC5489357
• Grogan, S. P., Pauli, C., Lotz, M. K., D'Lima, D. D. Relevance of meniscal cell regional phenotype to tissue engineering Connective Tissue Research  2017 58:259-270  DOI:10.1080/03008207.2016.1268604  PMID:27925477  PMCID:PMC5433889
• Hasegawa, A., Yonezawa, T., Taniguchi, N., Otabe, K., Akasaki, Y., Matsukawa, T., Saito, M., Neo, M., Marmorstein, L. Y., Lotz, M. K. Role of fibulin 3 in aging-related joint changes and osteoarthritis pathogenesis in human and mouse knee cartilage Arthritis & Rheumatology  2017 69:576-585  DOI:10.1002/art.39963  PMID:27780308  PMCID:PMC5328782
• Rodeo, S., Buckwalter, J. A., Lotz, M. Special issue: Injury and post-traumatic osteoarthritis Journal of Orthopaedic Research  2017 35:395-396  DOI:10.1002/jor.23546  PMID:28297745
• Shen, T., Alvarez-Garcia, O., Li, Y., Olmer, M., Lotz, M. K. Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism Osteoarthritis and Cartilage  2017 25:287-296  DOI:10.1016/j.joca.2016.09.017  PMID:27693501  PMCID:PMC5258682
• Hasei, J., Teramura, T., Takehara, T., Onodera, Y., Horii, T., Olmer, M., Hatada, I., Fukuda, K., Ozaki, T., Lotz, M. K., Asahara, H. TWIST1 induces MMP3 expression through up-regulating DNA hydroxymethylation and promotes catabolic responses in human chondrocytes Scientific Reports  2017 7  DOI:10.1038/srep42990  PMID:28220902  PMCID:PMC5318945
• Asahara, H., Inui, M., Lotz, M. K. Tendons and ligaments: connecting developmental biology to musculoskeletal disease pathogenesis Journal of Bone and Mineral Research  2017 32:1773-1782  DOI:10.1002/jbmr.3199  PMID:28621492
• Matsuzaki, T., Akasaki, Y., Olmer, M., Alvarez-Garcia, O., Reixach, N., Buxbaum, J. N., Lotz, M. K. Transthyretin deposition promotes progression of osteoarthritis Aging Cell  2017 16:1313-1322  DOI:10.1111/acel.12665  PMID:28941045  PMCID:PMC5676063
• Suzuki, H., Ito, Y., Shinohara, M., Yamashita, S., Ichinose, S., Kishida, A., Oyaizu, T., Kayama, T., Nakamichi, R., Koda, N., Yagishita, K., Lotz, M. K., et al. Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis Proceedings of the National Academy of Sciences of the United States of America  2016 113:7840-7845  DOI:10.1073/pnas.1522054113  PMID:27370800  PMCID:PMC4948356
• Kwok, J., Onuma, H., Olmer, M., Lotz, M. K., Grogan, S. P., D'Lima, D. D. Histopathological analyses of murine menisci: implications for joint aging and osteoarthritis Osteoarthritis and Cartilage  2016 24:709-718  DOI:10.1016/j.joca.2015.11.006  PMID:26585241  PMCID:PMC4799761
• Temple-Wong, M. M., Ren, S., Quach, P., Hansen, B. C., Chen, A. C., Hasegawa, A., D'Lima, D. D., Koziol, J., Masuda, K., Lotz, M. K., Sah, R. L. Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration Arthritis Research & Therapy  2016 18  DOI:10.1186/s13075-016-0922-4  PMID:26792492  PMCID:PMC4721052
• Alvarez-Garcia, O., Fisch, K. M., Wineinger, N. E., Akagi, R., Saito, M., Sasho, T., Su, A. I., Lotz, M. K. Increased DNA methylation and reduced expression of transcription factors in human osteoarthritis cartilage Arthritis & Rheumatology  2016 68:1876-1886  DOI:10.1002/art.39643  PMID:26881698  PMCID:PMC4963260
• van Loosdregt, J., Rossetti, M., Spreafico, R., Moshref, M., Olmer, M., Williams, G. W., Kumar, P., Copeland, D., Pischel, K., Lotz, M., Albani, S. Increased autophagy in CD4(+) T cells of rheumatoid arthritis patients results in T-cell hyperactivation and apoptosis resistance European Journal of Immunology  2016 46:2862-2870  DOI:10.1002/eji.201646375  PMID:27624289  PMCID:PMC5138112
• D'Adamo, S., Alvarez-Garcia, O., Muramatsu, Y., Flamigni, F., Lotz, M. K. MicroRNA-155 suppresses autophagy in chondrocytes by modulating expression of autophagy proteins Osteoarthritis and Cartilage  2016 24:1082-1091  DOI:10.1016/j.joca.2016.01.005  PMID:26805019  PMCID:PMC4875787
• Nakamichi, R., Ito, Y., Inui, M., Onizuka, N., Kayama, T., Kataoka, K., Suzuki, H., Mori, M., Inagawa, M., Ichinose, S., Lotz, M. K., Sakai, D., et al. Mohawk promotes the maintenance and regeneration of the outer annulus fibrosus of intervertebral discs Nature Communications  2016 7  DOI:10.1038/ncomms12503  PMID:27527664  PMCID:PMC4990710
• Alvarez-Garcia, O., Olmer, M., Akagi, R., Akasaki, Y., Fisch, K. M., Shen, T., Su, A. I., Lotz, M. K. Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy Osteoarthritis and Cartilage  2016 24:1639-1647  DOI:10.1016/j.joca.2016.04.015  PMID:27118398  PMCID:PMC4992644
• Yamanaka, Y., Faghihi, M. A., Magistri, M., Alvarez-Garcia, O., Lotz, M., Wahlestedt, C. Antisense RNA controls LRP1 sense transcript expression through interaction with a chromatin-associated protein, HMGB2 Cell Reports  2015 11:967-976  DOI:10.1016/j.celrep.2015.04.011  PMID:25937287  PMCID:PMC4431949
• Lopez de Figueroa, P., Lotz, M. K., Blanco, F. J., Carames, B. Autophagy activation and protection from mitochondrial dysfunction in human chondrocytes Arthritis & Rheumatology  2015 67:966-976  DOI:10.1002/art.39025  PMID:25605458  PMCID:PMC4380780
• Takada, T., Miyaki, S., Ishitobi, H., Hirai, Y., Nakasa, T., Igarashi, K., Lotz, M. K., Ochi, M. Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1 Arthritis Research & Therapy  2015 17:285  DOI:10.1186/s13075-015-0792-1  PMID:26458773  PMCID:PMC4603301
• Hoshiyama, Y., Otsuki, S., Oda, S., Kurokawa, Y., Nakajima, M., Jotoku, T., Tamura, R., Okamoto, Y., Lotz, M. K., Neo, M. Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells Journal of Orthopaedic Research  2015 33:548-555  DOI:10.1002/jor.22782  PMID:25691232  PMCID:PMC4454425
• Wang, Y., Zhao, X., Lotz, M., Terkeltaub, R., Liu-Bryan, R. Mitochondrial biogenesis is impaired in osteoarthritis chondrocytes but reversible via peroxisome proliferator-activated receptor γ coactivator 1α. Arthritis & Rheumatology  2015 67:2141-2153  DOI:10.1002/art.39182  PMID:25940958  PMCID:PMC4519411
• Carames, B., Olmer, M., Kiosses, W. B., Lotz, M. K. The relationship of autophagy defects to cartilage damage during joint aging in a mouse model Arthritis & Rheumatology  2015 67:1568-1576  DOI:10.1002/art.39073  PMID:25708836  PMCID:PMC4446178
• Otabe, K., Nakahara, H., Hasegawa, A., Matsukawa, T., Ayabe, F., Onizuka, N., Inui, M., Takada, S., Ito, Y., Sekiya, I., Muneta, T., Lotz, M., et al. Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo Journal of Orthopaedic Research  2015 33:1-8  DOI:10.1002/jor.22750  PMID:25312837  PMCID:PMC4294629
• Akasaki, Y., Reixach, N., Matsuzaki, T., Alvarez-Garcia, O., Olmer, M., Iwamoto, Y., Buxbaum, J. N., Lotz, M. K. Transthyretin deposition in articular cartilage: a novel mechanism in the pathogenesis of osteoarthritis Arthritis & Rheumatology  2015 67:2097-2107  DOI:10.1002/art.39178  PMID:25940564  PMCID:PMC4519374
• Grogan, S. P., Chen, X., Sovani, S., Taniguchi, N., Colwell Jr., C. W., Lotz, M. K., D'Lima, D. D. Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation Tissue Engineering Part A  2014 20:264-274  DOI:10.1089/ten.tea.2012.0618  PMID:23962090  PMCID:PMC3875188
• Shapiro, I. M., Layfield, R., Lotz, M., Settembre, C., Whitehouse, C. Boning up on autophagy: the role of autophagy in skeletal biology Autophagy  2014 10:7-19  DOI:10.4161/auto.26679  PMID:24225636  PMCID:PMC4028324
• Akasaki, Y., Hasegawa, A., Saito, M., Asahara, H., Iwamoto, Y., Lotz, M. K. Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis Osteoarthritis and Cartilage  2014 22:162-170  DOI:10.1016/j.joca.2013.11.004  PMID:24269635  PMCID:PMC3932989
• Kato, T., Miyaki, S., Ishitobi, H., Nakamura, Y., Nakasa, T., Lotz, M. K., Ochi, M. Exosomes from IL-1β stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes Arthritis Research & Therapy  2014 16:R163  DOI:10.1186/ar4679  PMID:25092378  PMCID:PMC4261911
• Akasaki, Y., Alvarez-Garcia, O., Saito, M., Carames, B., Iwamoto, Y., Lotz, M. K. FoxO transcription factors support oxidative stress resistance in human chondrocytes Arthritis & Rheumatology  2014 66:3349-3358  DOI:10.1002/art.38868  PMID:25186470  PMCID:PMC4254812
• Alvarez-Garcia, O., Rogers, N. H., Smith, R. G., Lotz, M. K. Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1 Arthritis & Rheumatology  2014 66:1779-1788  DOI:10.1002/art.38399  PMID:24591481  PMCID:PMC4077915
• Zhao, X., Petursson, F., Viollet, B., Lotz, M., Terkeltaub, R., Liu-Bryan, R. Peroxisome proliferator-activated receptor γ coactivator 1α and FoxO3A mediate chondroprotection by AMP-activated protein kinase Arthritis & Rheumatology  2014 66:3073-3082  DOI:10.1002/art.38791  PMID:25047750  PMCID:PMC4343036
• Olee, T., Grogan, S. P., Lotz, M. K., Colwell, C. W., D'Lima, D. D., Snyder, E. Y. Repair of cartilage defects in arthritic tissue with differentiated human embryonic stem cells Tissue Engineering Part A  2014 20:683-692  DOI:10.1089/ten.tea.2012.0751  PMID:24028447  PMCID:PMC3926163
• Onizuka, N., Ito, Y., Inagawa, M., Nakahara, H., Takada, S., Lotz, M., Toyama, Y., Asahara, H. The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates Journal of Orthopaedic Science  2014 19:172-180  DOI:10.1007/s00776-013-0485-z  PMID:24166359  PMCID:PMC3943675
• Yoshitaka, T., Kawai, A., Miyaki, S., Numoto, K., Kikuta, K., Ozaki, T., Lotz, M., Asahara, H. Analysis of microRNAs expressions in chondrosarcoma Journal of Orthopaedic Research  2013 31:1992-1998  DOI:10.1002/jor.22457  PMID:23940002  PMCID:PMC3835201
• Husa, M., Petursson, F., Lotz, M., Terkeltaub, R., Liu-Bryan, R. C/EBP homologous protein drives pro-catabolic responses in chondrocytes Arthritis Research & Therapy  2013 15:R218  DOI:10.1186/ar4415  PMID:24351550  PMCID:PMC3978428
• Hasegawa, A., Nakahara, H., Kinoshita, M., Asahara, H., Koziol, J., Lotz, M. K. Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis Arthritis Research & Therapy  2013 15:R29  DOI:10.1186/ar4165  PMID:23406989  PMCID:PMC3672799
• Grogan, S. P., Chung, P. H., Soman, P., Chen, P., Lotz, M. K., Chen, S. C., D'Lima, D. D. Digital micromirror device projection printing system for meniscus tissue engineering Acta Biomaterialia  2013 9:7218-7226  DOI:10.1016/j.actbio.2013.03.020  PMID:23523536  PMCID:PMC3685281
• Carames, B., Kiosses, W. B., Akasaki, Y., Brinson, D. C., Eap, W., Koziol, J., Lotz, M. K. Glucosamine activates autophagy in vitro and in vivo Arthritis and Rheumatism  2013 65:1843-1852  DOI:10.1002/art.37977  PMID:23606170  PMCID:PMC3772083
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• van Loosdregt, J., Spreafico, R., Rossetti, M., Prakken, B. J., Lotz, M., Albani, S. Hydroxychloroquine preferentially induces apoptosis of CD45RO(+) effector T cells by inhibiting autophagy: A possible mechanism for therapeutic modulation of T cells Journal of Allergy and Clinical Immunology  2013 131:1443-1446  DOI:10.1016/j.jaci.2013.02.026  PMID:23541328  PMCID:PMC3955204
• Petursson, F., Husa, M., June, R., Lotz, M., Terkeltaub, R., Liu-Bryan, R. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes Arthritis Research & Therapy  2013 15:R77  DOI:10.1186/ar4254  PMID:23883619  PMCID:PMC3979085
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• Cui, X. F., Breitenkamp, K., Finn, M. G., Lotz, M., D'Lima, D. D. Direct human cartilage repair using three-dimensional bioprinting technology Tissue Engineering Part A  2012 18:1304-1312  DOI:10.1089/ten.tea.2011.0543  PMID:22394017  PMCID:PMC3360507
• Lotz, M., Loeser, R. F. Effects of aging on articular cartilage homeostasis Bone  2012 51:241-248  DOI:10.1016/j.bone.2012.03.023  PMID:22487298  PMCID:PMC3372644
• Grogan, S. P., Sovani, S., Pauli, C., Chen, J. F., Hartmann, A., Colwell, C. W., Lotz, M. K., D'Lima, D. D. Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels Tissue Engineering Part A  2012 18:1784-1792  DOI:10.1089/ten.tea.2011.0506  PMID:22536910  PMCID:PMC3432904
• Grogan, S. P., Pauli, C., Chen, P., Du, J., Chung, C. B., Kong, S. D., Colwell, C. W., Lotz, M. K., Jin, S. G., D'Lima, D. D. In situ tissue engineering using magnetically guided three-dimensional cell patterning Tissue Engineering Part C-Methods  2012 18:496-506  DOI:10.1089/ten.tec.2011.0525  PMID:22224660  PMCID:PMC3381294
• Carames, B., Taniguchi, N., Seino, D., Blanco, F. J., D'Lima, D., Lotz, M. Mechanical injury suppresses autophagy regulators and pharmacologic activation of autophagy results in chondroprotection Arthritis and Rheumatism  2012 64:1182-1192  DOI:10.1002/art.33444  PMID:22034068  PMCID:PMC3288456
• Lotz, M. Osteoarthritis year 2011 in review: Biology Osteoarthritis and Cartilage  2012 20:192-196  DOI:10.1016/j.joca.2011.11.015  PMID:22179031  PMCID:PMC3288592
• Chan, E. F., Harjanto, R., Asahara, H., Inoue, N., Masuda, K., Bugbee, W. D., Firestein, G. S., Hosalkar, H. S., Lotz, M. K., Sah, R. L. Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice Orthopedic Clinics of North America  2012 43:173-85  DOI:10.1016/j.ocl.2012.01.005  PMID:22480467  PMCID:PMC3321216
• Cui, X. F., Hasegawa, A., Lotz, M., D'Lima, D. Structured three-dimensional co-culture of mesenchymal stem cells with meniscus cells promotes meniscal phenotype without hypertrophy Biotechnology and Bioengineering  2012 109:2369-2380  DOI:10.1002/bit.24495  PMID:22422555  PMCID:PMC3391334
• Cui, X. F., Breitenkamp, K., Lotz, M., D'Lima, D. Synergistic action of fibroblast growth factor-2 and transforming growth factor-beta1 enhances bioprinted human neocartilage formation Biotechnology and Bioengineering  2012 109:2357-2368  DOI:10.1002/bit.24488  PMID:22508498  PMCID:PMC3402696
• Cui, X., Boland, T., D'Lima, D. D., Lotz, M. K. Thermal inkjet printing in tissue engineering and regenerative medicine Recent Patents on Drug Delivery & Formulation  2012 6:149-155  PMID:22436025  PMCID:PMC3565591
• Pauli, C., Bae, W. C., Lee, M., Lotz, M., Bydder, G. M., D'Lima, D. L., Chung, C. B., Du, J. Ultrashort-echo time MR imaging of the patella with bicomponent analysis: correlation with histopathologic and polarized light microscopic findings Radiology  2012 264:484-493  DOI:10.1148/radiol.12111883  PMID:22653187  PMCID:PMC3401353
• Lotz, M. K., Carames, B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA Nature Reviews Rheumatology  2011 7:579-587  DOI:10.1038/nrrheum.2011.109  PMID:21808292  PMCID:PMC3192496
• Terkeltaub, R., Yang, B., Lotz, M., Liu-Bryan, R. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha Arthritis and Rheumatism  2011 63:1928-1937  DOI:10.1002/art.30333  PMID:21400477  PMCID:PMC3128233
• Taniguchi, N., Carames, B., Hsu, E., Cherqui, S., Kawakami, Y., Lotz, M. Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation Journal of Biological Chemistry  2011 286:41489-41498  DOI:10.1074/jbc.M111.236984  PMID:21890638  PMCID:PMC3308860
• Itou, J., Taniguchi, N., Oishi, I., Kawakami, H., Lotz, M., Kawakami, Y. HMGB factors are required for posterior digit development through integrating signaling pathway activities Developmental Dynamics  2011 240:1151-1162  DOI:10.1002/dvdy.22598  PMID:21384471  PMCID:PMC3081368
• Pauli, C., Grogan, S. P., Patil, S., Otsuki, S., Hasegawa, A., Koziol, J., Lotz, M. K., D'Lima, D. D. Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis Osteoarthritis and Cartilage  2011 19:1132-1141  DOI:10.1016/j.joca.2011.05.008  PMID:21683797  PMCID:PMC3217905
• Haudenschild, D. R., Chen, J. F., Pang, N. N., Steklov, N., Grogan, S. P., Lotz, M. K., D'Lima, D. D. Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis Journal of Orthopaedic Research  2011 29:20-25  DOI:10.1002/jor.21198  PMID:20602472  PMCID:PMC2976780
• Carames, B., Taniguchi, N., Otsuki, S., Blanco, F. J., Lotz, M. Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis Arthritis and Rheumatism  2010 62:791-801  DOI:10.1002/art.27305  PMID:20187128  PMCID:PMC2838960
• Lotz, M. K., Otsuki, S., Grogan, S. P., Sah, R., Terkeltaub, R., D'Lima, D. Cartilage cell clusters Arthritis and Rheumatism  2010 62:2206-2218  DOI:10.1002/art.27528  PMID:20506158  PMCID:PMC2921934
• Higashiyama, R., Miyaki, S., Yamashita, S., Yoshitaka, T., Lindman, G., Ito, Y., Sasho, T., Takahashi, K., Lotz, M., Asahara, H. Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis Modern Rheumatology  2010 20:11-17  DOI:10.1007/s10165-009-0224-7  PMID:19784544  PMCID:PMC2818344
• Otsuki, S., Hanson, S. R., Miyaki, S., Grogan, S. P., Kinoshita, M., Asahara, H., Wong, C. H., Lotz, M. K. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways Proceedings of the National Academy of Sciences of the United States of America  2010 107:10202-10207  DOI:10.1073/pnas.0913897107  PMID:20479257  PMCID:PMC2890424
• Schelwies, M., Brinson, D., Otsuki, S., Hong, Y. H., Lotz, M. K., Wong, C. H., Hanson, S. R. Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases ChemBioChem  2010 11:2393-2397  DOI:10.1002/cbic.201000401  PMID:20973023  PMCID:PMC3086843
• Oyama, Y., Hashiguchi, T., Taniguchi, N., Tancharoen, S., Uchimura, T., Biswas, K. K., Kawahara, K., Nitanda, T., Umekita, Y., Lotz, M., Maruyama, I. High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy Laboratory Investigation  2010 90:853-866  DOI:10.1038/labinvest.2010.64  PMID:20231821  PMCID:PMC3096665
• Miyaki, S., Sato, T., Inoue, A., Otsuki, S., Ito, Y., Yokoyama, S., Kato, Y., Takemoto, F., Nakasa, T., Yamashita, S., Takada, S., Lotz, M. K., et al. MicroRNA-140 plays dual roles in both cartilage development and homeostasis Genes & Development  2010 24:1173-1185  DOI:10.1101/gad.1915510  PMID:20466812  PMCID:PMC2878654
• Lotz, M. K. Posttraumatic osteoarthritis: Pathogenesis and pharmacological treatment options Arthritis Research & Therapy  2010 12:211  DOI:10.1186/ar3046  PMID:20602810  PMCID:PMC2911903
• Haudenschild, D. R., Chen, J. F., Pang, N. N., Lotz, M. K., D'Lima, D. D. Rho kinase-dependent activation of SOX9 in chondrocytes Arthritis and Rheumatism  2010 62:191-200  DOI:10.1002/art.25051  PMID:20039424  PMCID:PMC2935318
• Otsuki, S., Grogan, S. P., Miyaki, S., Kinoshita, M., Asahara, H., Lotz, M. K. Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage Journal of Orthopaedic Research  2010 28:96-102  DOI:10.1002/jor.20944  PMID:19603515  PMCID:PMC2905317
• Steklov, N., Srivastava, A., Sung, K. L., Chen, P. C., Lotz, M. K., D'Lima, D. D. Aging-related differences in chondrocyte viscoelastic properties Molecular & Cellular Biomechanics  2009 6:113-119  PMID:19496259
• Taniguchi, N., Carames, B., Ronfani, L., Ulmer, U., Komiya, S., Bianchi, M. E., Lotz, M. Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis Proceedings of the National Academy of Sciences of the United States of America  2009 106:1181-1186  DOI:10.1073/pnas.0806062106  PMID:19139395  PMCID:PMC2633567
• Garcia-Gonzalez, A., Lotz, M., Ochoa, J. L. Anti-inflammatory activity of superoxide dismutase obtained from Debaryomyces hansenii on type II collagen induced arthritis in rats Revista de Investigacion Clinica  2009 61:212-220  PMID:19736810
• Ito, T., Yadav, N., Lee, J., Furumatsu, T., Yamashita, S., Yoshida, K., Taniguchi, N., Hashimoto, M., Tsuchiya, M., Ozaki, T., Lotz, M., Bedford, M. T., et al. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification BMC Developmental Biology  2009 9:47  DOI:10.1186/1471-213x-9-47  PMID:19725955  PMCID:PMC2754437
• Temple-Wong, M. M., Bae, W. C., Chen, M. Q., Bugbee, W. D., Amiel, D., Coutts, R. D., Lotz, M., Sah, R. L. Biomechanical, structural, and biochemical indices of degenerative and osteoarthritic deterioration of adult human articular cartilage of the femoral condyle Osteoarthritis and Cartilage  2009 17:1469-1476  DOI:10.1016/j.joca.2009.04.017  PMID:19464244  PMCID:PMC2763930
• Haudenschild, D. R., Chen, J., Steklov, N., Lotz, M. K., D'Lima, D. D. Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli Molecular & Cellular Biomechanics  2009 6:135-144  PMID:19670824  PMCID:PMC2785729
• Taniguchi, N., Carames, B., Kawakami, Y., Amendt, B. A., Komiya, S., Lotz, M. Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway Proceedings of the National Academy of Sciences of the United States of America  2009 106:16817-16822  DOI:10.1073/pnas.0904414106  PMID:19805379  PMCID:PMC2757822
• Shikhman, A. R., Brinson, D. C., Valbracht, J., Lotz, M. K. Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes Osteoarthritis and Cartilage  2009 17:1022-1028  DOI:10.1016/j.joca.2009.03.004  PMID:19332174  PMCID:PMC2785807
• Grogan, S. P., Miyaki, S., Asahara, H., D'Lima, D. D., Lotz, M. K. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis Arthritis Research & Therapy  2009 11:R85  DOI:10.1186/ar2719  PMID:19500336  PMCID:PMC2714136
• Miyaki, S., Nakasa, T., Otsuki, S., Grogan, S. P., Higashiyama, R., Inoue, A., Kato, Y., Sato, T., Lotz, M. K., Asahara, H. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses Arthritis and Rheumatism  2009 60:2723-2730  DOI:10.1002/art.24745  PMID:19714579  PMCID:PMC2806094
• Brown, K. D., Koziol, J. A., Lotz, M. A yoga-based exercise program to reduce the risk of falls in seniors: a pilot and feasibility study Journal of Alternative and Complementary Medicine  2008 14:454-457  DOI:10.1089/acm.2007.0797  PMID:18564950
• Wong, B. L., Bae, W. C., Chun, J., Gratz, K. R., Lotz, M., Sah, R. L. Biomechanics of cartilage articulation Arthritis and Rheumatism  2008 58:2065-2074  DOI:10.1002/art.23548  PMID:18576324
• Mishima, Y., Lotz, M. Chemotaxis of human articular chondrocytes and mesenchymal stem cells Journal of Orthopaedic Research  2008 26:1407-1412  DOI:10.1002/jor.20668  PMID:18464249
• Haudenschild, D. R., D'Lima, D. D., Lotz, M. K. Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton Biorheology  2008 45:219-228  DOI:10.3233/bir-2008-0499  PMID:18836226
• Otsuki, S., Taniguchi, N., Grogan, S. P., D'Lima, D., Kinoshita, M., Lotz, M. Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage Arthritis Research & Therapy  2008 10:R61  DOI:10.1186/ar2432  PMID:18507859  PMCID:PMC2483452
• Otsuki, S., Nakajima, M., Lotz, M., Kinoshita, M. Hyaluronic acid and chondroitin sulfate content of osteoarthritic human knee cartilage: Site-specific correlation with weight-bearing force based on femorotibial angle measurement Journal of Orthopaedic Research  2008 26:1194-1198  DOI:10.1002/jor.20571  PMID:18383185
• Grogan, S. P., Olee, T., Hiraoka, K., Lotz, M. K. Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site Arthritis and Rheumatism  2008 58:2754-2763  DOI:10.1002/art.23730  PMID:18759300  PMCID:PMC2786215
• Haudenschild, D. R., Nguyen, B., Chen, J., D'Lima, D. D., Lotz, M. K. Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes Arthritis and Rheumatism  2008 58:2735-2742  DOI:10.1002/art.23797  PMID:18759278  PMCID:PMC2562294
• Otsuki, S., Brinson, D. C., Creighton, L., Kinoshita, M., Sah, R. L., D'Lima, D., Lotz, M. The effect of glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants Arthritis and Rheumatism  2008 58:1076-1085  DOI:10.1002/art.23381  PMID:18383360
• Temple, M. M., Bae, W. C., Chen, M. Q., Lotz, M., Amiel, D., Coufts, R. D., Sah, R. L. Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle Osteoarthritis and Cartilage  2007 15:1042-1052  DOI:10.1016/j.joca.2007.03.005  PMID:17468016
• Taniguchi, N., Yoshida, K., Ito, T., Tsuda, M., Mishima, Y., Furumatsu, T., Ronfani, L., Abeyama, K., Kawahara, K., Komiya, S., Maruyama, I., Lotz, M., et al. Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification Molecular and Cellular Biology  2007 27:5650-5663  DOI:10.1128/mcb.00130-07  PMID:17548469
• D'Lima, D., Hermida, J., Hashimoto, S., Colwell, C., Lotz, M. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis Arthritis and Rheumatism  2006 54:1814-1821  DOI:10.1002/art.21874  PMID:16736522
• Hiraoka, K., Grogan, S., Olee, T., Lotz, M. Mesenchymal progenitor cells in adult human articular cartilage Biorheology  2006 43:447-454  PMID:16912416
• Shikhman, A. R., Amiel, D., D'Lima, D., Hwang, S. B., Hu, C., Xu, A., Hashimoto, S., Kobayashi, K., Sasho, T., Lotz, M. K. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis Annals of the Rheumatic Diseases  2005 64:89-94  DOI:10.1136/ard.2003.019406  PMID:15608304  PMCID:PMC1755188
• Daouti, S., Latario, B., Nagulapalli, S., Buxton, F., Uziel-Fusi, S., Chirn, G. W., Bodian, D., Song, C., Labow, M., Lotz, M., Quintavalla, J., Kumar, C. Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis Osteoarthritis and Cartilage  2005 13:508-518  DOI:10.1016/j.joca.2005.02.003  PMID:15922185
• Kinney, R. C., Schwartz, Z., Week, K., Lotz, M. K., Boyan, B. D. Human articular chondrocytes exhibit sexual dimorphism in their responses to 17 beta-estradiol Osteoarthritis and Cartilage  2005 13:330-337  DOI:10.1016/j.joca.2004.12.003  PMID:15780646
• Cecil, D. L., Johnson, K., Rediske, J., Lotz, M., Schmidt, A. M., Terkeltaub, R. Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products Journal of Immunology  2005 175:8296-8302  PMID:16339570
• Kawakami, Y., Tsuda, M., Takahashi, S., Taniguchi, N., Esteban, C. R., Zemmyo, M., Furumatsu, T., Lotz, M., Belmonte, J. C. I., Asahara, H. Transcriptional coactivator PGC-1 alpha regulates chondrogenesis via association with Sox9 Proceedings of the National Academy of Sciences of the United States of America  2005 102:2414-2419  DOI:10.1073/pnas.0407510102  PMID:15699338  PMCID:PMC548985
• Kuhn, K., D'Lima, D. D., Hashimoto, S., Lotz, M. Cell death in cartilage Osteoarthritis and Cartilage  2004 12:1-16  DOI:10.1016/j.joca.2003.09.015  PMID:14697678
• D'Lima, D. D., Kuhn, K., Lotz, M. K. Detection of apoptosis in cartilage in situ and in isolated chondrocytes Methods in Molecular Medicine  2004 100:275-290  DOI:10.1385/1-59259-810-2:275  PMID:15280601
• Shikhman, A. R., Brinson, D. C., Lotz, M. K. Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses American Journal of Physiology-Endocrinology and Metabolism  2004 286:E980-E985  DOI:10.1152/ajpendo.00243.2003  PMID:14749204
• Alsalameh, S., Amin, R., Gemba, T., Lotz, M. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage Arthritis and Rheumatism  2004 50:1522-1532  DOI:10.1002/art.20269  PMID:15146422
• Sen, M., Cheng, Y. H., Goldring, M. B., Lotz, M. K., Carson, D. A. WISP3-dependent regulation aggrecan production of type II collagen and in chondrocytes Arthritis and Rheumatism  2004 50:488-497  DOI:10.1002/art.20005  PMID:14872491
• Zemmyo, M., Meharra, E. J., Kuhn, K., Creighton-Achermann, L., Lotz, M. Accelerated, aging-dependent development of osteoarthritis in alpha 1 integrin-deficient mice Arthritis and Rheumatism  2003 48:2873-2880  DOI:10.1002/art.11246  PMID:14558093
• Seitz, M., Valbracht, J., Quach, J., Lotz, M. Gold sodium thiomalate and chloroquine inhibit cytokine production in monocytic THP-1 cells through distinct transcriptional and posttranslational mechanisms Journal of Clinical Immunology  2003 23:477-484  DOI:10.1023/b:joci.0000010424.41475.17  PMID:15031635
• Kuhn, K., Lotz, M. Mechanisms of sodium nitroprusside-induced death in human chondrocytes Rheumatology International  2003 23:241-247  DOI:10.1007/s00296-003-0299-y  PMID:14504917
• Kuhn, K., Shikhman, A. R., Lotz, M. Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in the regulation of human chondrocyte apoptosis Journal of Cellular Physiology  2003 197:379-387  DOI:10.1002/jcp.10372  PMID:14566967
• D'Lima, D., Lotz, M., Colwell, C. Impact loading: physiological or pathological? Response Osteoarthritis and Cartilage  2002 10:590-590  DOI:10.1053/joca.2002.0804
• Hashimoto, S., Creighton-Achermann, L., Takahashi, K., Amiel, D., Coutts, R. D., Lotz, M. Development and regulation of osteophyte formation during experimental osteoarthritis Osteoarthritis and Cartilage  2002 10:180-187  DOI:10.1053/joca.2001.0505  PMID:11869078
• Gemba, T., Valbracht, J., Alsalameh, S., Lotz, M. Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment Journal of Biological Chemistry  2002 277:907-911  DOI:10.1074/jbc.M109690200  PMID:11677248
• Yamada, K., Healey, R., Amiel, D., Lotz, M., Coutts, R. Subchondral bone of the human knee in aging and osteoarthritis Osteoarthritis and Cartilage  2002 10:360-369  DOI:10.1053/joca.2002.0525  PMID:12027537
• Colwell, C. W., D'Lima, D. D., Lotz, M. Association of bone and joint surgeons workshop supplement - Editorial comment Clinical Orthopaedics and Related Research  2001 S2-S5
• D'Lima, D. D., Hashimoto, S., Chen, P. C., Lotz, M. K., Colwell, C. W. Cartilage injury induces chondrocyte apoptosis Journal of Bone and Joint Surgery-American Volume  2001 83A:19-21  DOI:10.2106/00004623-200100021-00004  PMID:11685837
• Kobayashi, K., Mishima, H., Hashimoto, S., Goomer, R. S., Harwood, F. L., Lotz, M., Moriya, H., Amiel, D. Chondrocyte apoptosis and regional differential expression of nitric oxide in the medial meniscus following partial meniscectomy Journal of Orthopaedic Research  2001 19:802-808  DOI:10.1016/s0736-0266(01)00023-7  PMID:11562124
• Shikhman, A. R., Brinson, D. C., Valbracht, J., Lotz, M. K. Cytokine regulation of facilitated glucose transport in human articular chondrocytes Journal of Immunology  2001 167:7001-7008  PMID:11739520
• Lotz, M. Cytokines in cartilage injury and repair Clinical Orthopaedics and Related Research  2001 391:S108-S115  PMID:11603695
• Liu, J., Shikhman, A. R., Lotz, M. K., Wong, C. H. Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis Chemistry & Biology  2001 8:701-711  DOI:10.1016/s1074-5521(01)00045-x  PMID:11451670
• D'Lima, D. D., Hashimoto, S., Chen, P. C., Colwell, C. W., Lotz, M. K. Human chondrocyte apoptosis in response to mechanical injury Osteoarthritis and Cartilage  2001 9:712-719  DOI:10.1053/joca.2001.0468  PMID:11795990
• Takahashi, K., Hashimoto, S., Kubo, T., Hirasawa, Y., Lotz, M., Amiel, D. Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model Journal of Orthopaedic Research  2001 19:500-503  DOI:10.1016/s0736-0266(00)90024-x  PMID:11398866
• D'Lima, D. D., Hashimoto, S., Chen, P. C., Colwell, C. W., Lotz, M. K. Impact of mechanical trauma on matrix and cells Clinical Orthopaedics and Related Research  2001 391:S90-S99  PMID:11603728
• D'Lima, D. D., Hashimoto, S., Chen, P. C., Lotz, M. K., Colwell, C. W. In vitro and in vivo models of cartilage injury Journal of Bone and Joint Surgery-American Volume  2001 83A:22-24
• Colwell, C. W., D'Lima, D. A., Hoenecke, H. R., Fronek, J., Pulido, P., Morris, B. A., Chung, C., Resnick, D., Lotz, M. In vivo changes after mechanical injury Clinical Orthopaedics and Related Research  2001 391:S116-S123  PMID:11603696
• Johnson, K., Hashimoto, S., Lotz, M., Pritzker, K., Terkeltaub, R. Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa American Journal of Pathology  2001 159:149-163  DOI:10.1016/s0002-9440(10)61682-3  PMID:11438463
• Shikhman, A. R., Kuhn, K., Alaaeddine, N., Lotz, M. N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes Journal of Immunology  2001 166:5155-5160  PMID:11290798
• D'Lima, D. D., Hashimoto, S., Chen, P. C., Lotz, M. K., Colwell, C. W. Prevention of chondrocyte apoptosis Journal of Bone and Joint Surgery-American Volume  2001 83A:25-26  DOI:10.2106/00004623-200100021-00006  PMID:11685840
• Alaaeddine, N., Olee, T., Hashimoto, S., Creighton-Achermann, L., Lotz, M. Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation Arthritis and Rheumatism  2001 44:1633-1643  DOI:10.1002/1529-0131(200107)44:7<1633::aid-art286>3.0.co;2-z  PMID:11465714
• Kuhn, K., Lotz, M. Regulation of CD95 (Fas/APO-1)-induced apoptosis in human chondrocytes Arthritis and Rheumatism  2001 44:1644-1653  DOI:10.1002/1529-0131(200107)44:7<1644::aid-art287>3.0.co;2-s  PMID:11465715
• Johansen, J. S., Olee, T., Price, P. A., Hashimoto, S., Ochs, R. L., Lotz, M. Regulation of YKL-40 production by human articular chondrocytes Arthritis and Rheumatism  2001 44:826-837  DOI:10.1002/1529-0131(200104)44:4<826::aid-anr139>3.0.co;2-u  PMID:11315922
• Komuro, H., Olee, T., Kuhn, K., Quach, J., Brinson, D. C., Shikhman, A., Valbracht, J., Creighton-Achermann, L., Lotz, M. The osteoprotegerin/receptor activator of nuclear factor kappa B/receptor activator of nuclear factor kappa B ligand system in cartilage Arthritis and Rheumatism  2001 44:2768-2776  DOI:10.1002/1529-0131(200112)44:12<2768::aid-art464>3.0.co;2-i  PMID:11762937
• Johnson, K., Hashimoto, S., Lotz, M., Pritzker, K., Goding, J., Terkeltaub, R. Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification Arthritis and Rheumatism  2001 44:1071-1081  DOI:10.1002/1529-0131(200105)44:5<1071::aid-anr187>3.0.co;2-3  PMID:11352238
• Jin, G., Sah, R. L., Li, Y. S., Lotz, M., Shyy, J. Y. J., Chien, S. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes Journal of Orthopaedic Research  2000 18:899-908  DOI:10.1002/jor.1100180608  PMID:11192249
• Takahashi, K., Hashimoto, S., Kubo, T., Hirasawa, Y., Lotz, M., Amiel, D. Effect of hyaluronan on chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis Journal of Rheumatology  2000 27:1713-1720  PMID:10914857
• Dudler, J., Renggli-Zulliger, N., Busso, N., Lotz, M., So, A. Effect of interleukin 17 on proteoglycan degradation in murine knee joints Annals of the Rheumatic Diseases  2000 59:529-532  DOI:10.1136/ard.59.7.529  PMID:10873962  PMCID:PMC1753181
• Kuhn, K., Hashimoto, S., Lotz, M. IL-1 beta protects human chondrocytes from CD95-induced apoptosis Journal of Immunology  2000 164:2233-2239  PMID:10657679
• Shikhman, A. R., Brinson, D. C., Lotz, M. Profile of glycosaminoglycan-degrading glycosidases and glycoside sulfatases secreted by human articular chondrocytes in homeostasis and inflammation Arthritis and Rheumatism  2000 43:1307-1314  DOI:10.1002/1529-0131(200006)43:6<1307::aid-anr13>3.0.co;2-3  PMID:10857789
• Kuhn, K., Hashimoto, S., Lotz, M. Cell density modulates apoptosis in human articular chondrocytes Journal of Cellular Physiology  1999 180:439-447  DOI:10.1002/(sici)1097-4652(199909)180:3<439::aid-jcp15>3.0.co;2-d  PMID:10430184
• Olee, T., Hashimoto, S., Quach, J., Lotz, M. IL-18 is produced by articular chondrocytes and induces proinflammatory and catabolic responses Journal of Immunology  1999 162:1096-1100  PMID:9916738
• Lotz, M., Hashimoto, S., Kuhn, K. Mechanisms of chondrocyte apoptosis Osteoarthritis and Cartilage  1999 7:389-391  DOI:10.1053/joca.1998.0220  PMID:10419776
• Hashimoto, S., Takahashi, K., Ochs, R. L., Coutts, R. D., Amiel, D., Lotz, M. Nitric oxide production and apoptosis in cells of the meniscus during experimental osteoarthritis Arthritis and Rheumatism  1999 42:2123-2131  DOI:10.1002/1529-0131(199910)42:10<2123::aid-anr12>3.0.co;2-g  PMID:10524683
• Lotz, M. The role of nitric oxide in articular cartilage damage Rheumatic Disease Clinics of North America  1999 25:269-282  DOI:10.1016/s0889-857x(05)70067-3  PMID:10356417
• Hashimoto, S., Takahashi, K., Amiel, D., Coutts, R. D., Lotz, M. Chondrocyte apoptosis and nitric oxide production during experimentally induced osteoarthritis Arthritis and Rheumatism  1998 41:1266-1274  DOI:10.1002/1529-0131(199807)41:7<1266::aid-art18>3.0.co;2-y  PMID:9663485
• Hashimoto, S., Ochs, R. L., Rosen, F., Quach, J., McCabe, G., Solan, J., Seegmiller, J. E., Terkeltaub, R., Lotz, M. Chondrocyte-derived apoptotic bodies and calcification of articular cartilage Proceedings of the National Academy of Sciences of the United States of America  1998 95:3094-3099  DOI:10.1073/pnas.95.6.3094  PMID:9501221
• Geng, Y., Zhou, L., Thompson, W. J., Lotz, M. Cyclic GMP and cGMP-binding phosphodiesterase are required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes Journal of Biological Chemistry  1998 273:27484-27491  DOI:10.1074/jbc.273.42.27484  PMID:9765278
• Shalom-Barak, T., Quach, J., Lotz, M. Interleukin-17-induced gene expression in articular chondrocytes is associated with activation of mitogen-activated protein kinases and NF-kappa B Journal of Biological Chemistry  1998 273:27467-27473  DOI:10.1074/jbc.273.42.27467  PMID:9765276
• Hashimoto, S., Ochs, R. L., Komiya, S., Lotz, M. Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis Arthritis and Rheumatism  1998 41:1632-1638  DOI:10.1002/1529-0131(199809)41:9<1632::aid-art14>3.0.co;2-a  PMID:9751096
• Terkeltaub, R., Lotz, M., Johnson, K., Deng, D. L., Hashimoto, S., Goldring, M. B., Burton, D., Deftos, L. J. Parathyroid hormone-related protein is abundant in osteoarthritic cartilage, and the parathyroid hormone-related protein 1-173 isoform is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses generation of extracellular inorganic pyrophosphate Arthritis and Rheumatism  1998 41:2152-2164  DOI:10.1002/1529-0131(199812)41:12<2152::aid-art10>3.3.co;2-o  PMID:9870872
• Schwarz, H., Arden, K., Lotz, M. CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies Biochemical and Biophysical Research Communications  1997 235:699-703  DOI:10.1006/bbrc.1997.6870  PMID:9207223
• Rosen, F., McCabe, G., Quach, J., Solan, J., Terkeltaub, R., Seegmiller, J. E., Lotz, M. Differential effects of aging on human chondrocyte responses to transforming growth factor beta - increased pyrophosphate production and decreased cell proliferation Arthritis and Rheumatism  1997 40:1275-1281  DOI:10.1002/1529-0131(199707)40:7<1275::aid-art12>3.0.co;2-h  PMID:9214428
• vonKempis, J., Schwarz, H., Lotz, M. Differentiation-dependent and stimulus-specific expression of ILA, the human 4-1BB-homologue, in cells of mesenchymal origin Osteoarthritis and Cartilage  1997 5:394-406  PMID:9536288
• Hashimoto, S., Setareh, M., Ochs, R. L., Lotz, M. Fas/Fas ligand expression and induction of apoptosis in chondrocytes Arthritis and Rheumatism  1997 40:1749-1755  DOI:10.1002/art.1780401004  PMID:9336406
• Cai, J., Zheng, T., Lotz, M., Zhang, Y., Masood, R., Gill, P. Glucocorticoids induce Kaposi's sarcoma cell proliferation through the regulation of transforming growth factor-beta Blood  1997 89:1491-1500  PMID:9057628
• Zvaifler, N. J., Tsai, V., Alsalameh, S., vonKempis, J., Firestein, G. S., Lotz, M. Pannocytes: Distinctive cells found in rheumatoid arthritis articular cartilage erosions American Journal of Pathology  1997 150:1125-1138  PMID:9060847  PMCID:PMC1857892
• Shiraishi, A., Dudler, J., Lotz, M. The role of IFN regulatory factor-1 in synovitis and nitric oxide production Journal of Immunology  1997 159:3549-3554  PMID:9317154
• Schwarz, H., Blanco, F. J., vonKempis, J., Valbracht, J., Lotz, M. ILA, a member of the human nerve growth factor tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival Blood  1996 87:2839-2845  PMID:8639902
• Sato, Y., Roman, M., Tighe, H., Lee, D., Corr, M., Nguyen, M. D., Silverman, G. J., Lotz, M., Carson, D. A., Raz, E. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization Science  1996 273:352-354  DOI:10.1126/science.273.5273.352  PMID:8662521
• Geng, Y., Valbracht, J., Lotz, M. Selective activation of the mitogen-activated protein kinase subgroups C-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes Journal of Clinical Investigation  1996 98:2425-2430  DOI:10.1172/jci119056  PMID:8941662
• Maier, R., Wisniewski, H. G., Vilcek, J., Lotz, M. TSG-6 expression in human articular chondrocytes - possible implications in joint inflammation and cartilage degradation Arthritis and Rheumatism  1996 39:552-559  DOI:10.1002/art.1780390403  PMID:8630102
• Lotz, M., Setareh, M., vonKempis, J., Schwarz, H. The nerve growth factor/tumor necrosis factor receptor family Journal of Leukocyte Biology  1996 60:1-7  PMID:8699112
• Setareh, M., Schwarz, H., Lotz, M. A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGf/TNF receptor family Gene  1995 164:311-315  DOI:10.1016/0378-1119(95)00349-b  PMID:7590349
• Blanco, F. J., Ochs, R. L., Schwarz, H., Lotz, M. Chondrocyte apoptosis induced by nitric-oxide American Journal of Pathology  1995 146:75-85  PMID:7856740  PMCID:PMC1870754
• Lotz, M., Blanco, F. J., Vonkempis, J., Dudler, J., Maier, R., Villiger, P. M., Geng, Y. Cytokine regulation of chondrocyte functions Journal of Rheumatology  1995 22:104-108
• Blanco, F. J., Geng, Y., Lotz, M. Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric-oxide synthase expression Journal of Immunology  1995 154:4018-4026  PMID:7535818
• Guerne, P. A., Blanco, F., Kaelin, A., Desgeorges, A., Lotz, M. Growth-factor responsiveness of human articular chondrocytes in aging and development Arthritis and Rheumatism  1995 38:960-968  DOI:10.1002/art.1780380712  PMID:7612045
• Blanco, F. J., Lotz, M. IL-1-induced nitric-oxide inhibits chondrocyte proliferation via PGE2 Experimental Cell Research  1995 218:319-325  DOI:10.1006/excr.1995.1161  PMID:7537695
• Schwarz, H., Valbracht, J., Tuckwell, J., Vonkempis, J., Lotz, M. Ila, the human 4-1bb homolog, is inducible in lymphoid and other cell lineages Blood  1995 85:1043-1052  PMID:7849293
• Geng, Y., Lotz, M. Increased intracellular ca2+ selectively suppresses il-1-induced no production by reducing inos messenger-rna stability Journal of Cell Biology  1995 129:1651-1657  DOI:10.1083/jcb.129.6.1651  PMID:7540612
• Lotz, M., Rosen, F., McCabe, G., Quach, J., Blanco, F., Dudler, J., Solan, J., Goding, J., Seegmiller, J. E., Terkeltaub, R. Interleukin-1-beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes Proceedings of the National Academy of Sciences of the United States of America  1995 92:10364-10368  DOI:10.1073/pnas.92.22.10364  PMID:7479785
• Raz, E., Dudler, J., Lotz, M., Baird, S. M., Berry, C. C., Eisenberg, R. A., Carson, D. A. Modulation of disease-activity in murine systemic lupus-erythematosus by cytokine gene delivery Lupus  1995 4:286-292  DOI:10.1177/096120339500400409  PMID:8528225
• Geng, Y., Blanco, F. J., Cornelisson, M., Lotz, M. Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes Journal of Immunology  1995 155:796-801  PMID:7608556
• Geng, Y., Maier, R., Lotz, M. Tyrosine kinases are involved with the expression of inducible nitric-oxide synthase in human articular chondrocytes Journal of Cellular Physiology  1995 163:545-554  DOI:10.1002/jcp.1041630315  PMID:7539812
• Zuraw, B. L., Sugimoto, S., Parsons, C. L., Hugli, T., Lotz, M., Koziol, J. Activation of urinary kallikrein in patients with interstitial cystitis Journal of Urology  1994 152:874-878  PMID:8051740
• Schwarz, H., Blanco, F. J., Lotz, M. Anadamide, an endogenous cannabinoid receptor agonist inhibits lymphocyte-proliferation and induces apoptosis Journal of Neuroimmunology  1994 55:107-115  DOI:10.1016/0165-5728(94)90152-x  PMID:7962480
• Guerne, P. A., Sublet, A., Lotz, M. Growth-factor responsiveness of human articular chondrocytes - distinct profiles in primary chondrocytes, subcultured chondrocytes, and fibroblasts Journal of Cellular Physiology  1994 158:476-484  DOI:10.1002/jcp.1041580312  PMID:8126071
• Lotz, M., Clarklewis, I., Ganu, V. HIV-1 transactivator protein Tat induces proliferation and TGF-beta expression in human articular chondrocytes Journal of Cell Biology  1994 124:365-371  DOI:10.1083/jcb.124.3.365  PMID:8294518
• Maier, R., Bilbe, G., Rediske, J., Lotz, M. Inducible nitric-oxide synthase from human articular chondrocytes - cDNA cloning and analysis of messenger-RNA expression Biochimica et Biophysica Acta-Protein Structure and Molecular Enzymology  1994 1208:145-150  DOI:10.1016/0167-4838(94)90171-6
• Woods, V. L., Schreck, P. J., Gesink, D. S., Pacheco, H. O., Amiel, D., Akeson, W. H., Lotz, M. Integrin expression by human articular chondrocytes Arthritis and Rheumatism  1994 37:537-544  DOI:10.1002/art.1780370414  PMID:8147931
• Lotz, M., Villiger, P., Hugli, T., Koziol, J., Zuraw, B. L. Interleukin-6 and interstitial cystitis Journal of Urology  1994 152:869-873  PMID:8051739
• Geng, Y., Gulbins, E., Altman, A., Lotz, M. Monocyte deactivation by interleukin-10 via inhibition of tyrosine kinase-activity and the Ras signaling pathway Proceedings of the National Academy of Sciences of the United States of America  1994 91:8602-8606  DOI:10.1073/pnas.91.18.8602  PMID:8078929
• Schwarz, H., Villiger, P. M., Vonkempis, J., Lotz, M. Neuropeptide-Y is an inducible gene in the human immune-system Journal of Neuroimmunology  1994 51:53-61  DOI:10.1016/0165-5728(94)90128-7  PMID:8157736
• Broor, S., Kusari, A. B., Zhang, B. P., Seth, P., Richman, D. D., Carson, D. A., Wachsman, W., Lotz, M. Stimulation of HIV replication in mononuclear phagocytes by leukemia inhibitory factor Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology  1994 7:647-654  PMID:8207643
• Lotz, M., Ranheim, E., Kipps, T. J. Transforming growth-factor-beta as endogenous growth inhibitor of chronic lymphocytic-leukemia B-cells Journal of Experimental Medicine  1994 179:999-1004  DOI:10.1084/jem.179.3.999  PMID:8113691
• Schwarz, H., Tuckwell, J., Lotz, M. A receptor-induced by lymphocyte-activation (ILA) - a new member of the human nerve-growth-factor tumor-necrosis-factor receptor family Gene  1993 134:295-298  DOI:10.1016/0378-1119(93)90110-o  PMID:8262389
• Villiger, P. M., Kusari, A. B., Tendijke, P., Lotz, M. Il-1-beta and il-6 selectively induce transforming growth-factor-beta isoforms in human articular chondrocytes Journal of Immunology  1993 151:3337-3344  PMID:8376781
• Villiger, P. M., Geng, Y., Lotz, M. Induction of cytokine expression by leukemia inhibitory factor Journal of Clinical Investigation  1993 91:1575-1581  DOI:10.1172/jci116363  PMID:8473500
• Delcayre, A. X., Lotz, M., Lernhardt, W. Inhibition of Epstein-Barr virus-mediated capping of CD21 CR-2 by alpha-interferon (IFN-alpha) - immediate antiviral activity of IFN-alpha during the early phase of infection Journal of Virology  1993 67:2918-2921  PMID:8386282  PMCID:PMC237619
• Maier, R., Ganu, V., Lotz, M. Interleukin-11, an inducible cytokine in human articular chondrocytes and synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases Journal of Biological Chemistry  1993 268:21527-21532  PMID:8408003
• Lotz, M. Interleukin-6 Cancer Investigation  1993 11:732-742  DOI:10.3109/07357909309046948  PMID:8221206
• Geng, Y., Zhang, B. P., Lotz, M. Protein-tyrosine kinase activation is required for lipopolysaccharide induction of cytokines in human blood monocytes Journal of Immunology  1993 151:6692-6700  PMID:8258685
• Gross, V., Zhang, B. P., Geng, Y., Villiger, P. M., Lotz, M. Regulation of interleukin-6 (IL-6) expression - evidence for a tissue-specific role of protein-kinase-C Journal of Clinical Immunology  1993 13:310-320  DOI:10.1007/bf00920239  PMID:8245177
• Gross, V., Villiger, P. M., Zhang, B. P., Lotz, M. Retinoic acid inhibits interleukin-1 induced cytokine synthesis in human monocytes Journal of Leukocyte Biology  1993 54:125-132  PMID:8360592
• Raz, E., Watanabe, A., Baird, S. M., Eisenberg, R. A., Parr, T. B., Lotz, M., Kipps, T. J., Carson, D. A. Systemic immunological effects of cytokine genes injected into skeletal-muscle Proceedings of the National Academy of Sciences of the United States of America  1993 90:4523-4527  DOI:10.1073/pnas.90.10.4523  PMID:8506293
• Lotz, M., Seth, P. TGF beta and HIV infection Annals of the New York Academy of Sciences  1993 685:501-511  DOI:10.1111/j.1749-6632.1993.tb35912.x  PMID:7689810
• Wisniewski, H. G., Maier, R., Lotz, M., Lee, S., Klampfer, L., Lee, T. H., Vilcek, J. TSG-6 - a TNF-, IL-1-, and LPS-inducible secreted glycoprotein associated with arthritis Journal of Immunology  1993 151:6593-6601  PMID:8245487
• Machold, K. P., Carson, D. A., Lotz, M. Transforming growth-factor-beta (TGF-beta) inhibition of Epstein-Barr-virus (EBV)-4 and interleukin-4 (IL-4)-induced immunoglobulin production in human B-lymphocytes Journal of Clinical Immunology  1993 13:219-227  DOI:10.1007/bf00919975  PMID:8391546
• Lotz, M., Terkeltaub, R., Villiger, P. M. Cartilage and joint inflammation - regulation of IL-8 expression by human articular chondrocytes Journal of Immunology  1992 148:466-473  PMID:1729366
• Mandler, R. N., Kerrigan, D. P., Smart, J., Kuis, W., Villiger, P., Lotz, M. Castlemans disease in POEMS syndrome with elevated interleukin-6 Cancer  1992 69:2697-2703  DOI:10.1002/1097-0142(19920601)69:11<2697::aid-cncr2820691112>3.0.co;2-3  PMID:1571900
• Broide, D. H., Lotz, M., Cuomo, A. J., Coburn, D. A., Federman, E. C., Wasserman, S. I. Cytokines in symptomatic asthma airways Journal of Allergy and Clinical Immunology  1992 89:958-967  DOI:10.1016/0091-6749(92)90218-q  PMID:1374772
• Villiger, P. M., Lotz, M. Differential expression of tgf-beta isoforms by human articular chondrocytes in response to growth-factors Journal of Cellular Physiology  1992 151:318-325  DOI:10.1002/jcp.1041510213  PMID:1572906
• Villiger, P. M., Lotz, M. Expression of prepro-enkephalin in human articular chondrocytes is linked to cell-proliferation EMBO Journal  1992 11:135-143  PMID:1310929  PMCID:PMC556434
• Villiger, P. M., Fey, M. F., Lotz, M., Tobler, A. IgG2 and igG4 subclass deficiency and Evans syndrome in an adult patient Journal of Allergy and Clinical Immunology  1992 90:693-694  DOI:10.1016/0091-6749(92)90147-t  PMID:1401651
• Lotz, M., Moats, T., Villiger, P. M. Leukemia inhibitory factor is expressed in cartilage and synovium and can contribute to the pathogenesis of arthritis Journal of Clinical Investigation  1992 90:888-896  DOI:10.1172/jci115964  PMID:1522240
• Villiger, P. M., Terkeltaub, R., Lotz, M. Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acid Journal of Clinical Investigation  1992 90:488-496  DOI:10.1172/jci115885  PMID:1365641  PMCID:PMC443125
• Villiger, P. M., Terkeltaub, R., Lotz, M. Production of monocyte chemoattractant protein-1 by inflamed synovial tissue and cultured synoviocytes Journal of Immunology  1992 149:722-727  PMID:1624809
• Kuis, W., Villiger, P. M., Leser, H. G., Lotz, M. Differential processing of proenkephalin-A by human peripheral-blood monocytes and T lymphocytes Journal of Clinical Investigation  1991 88:817-824  DOI:10.1172/jci115382  PMID:1885771
• Delcayre, A. X., Salas, F., Mathur, S., Kovats, K., Lotz, M., Lernhardt, W. Epstein-Barr-virus complement C3d receptor is an interferon-alpha receptor EMBO Journal  1991 10:919-926  PMID:1849076  PMCID:PMC452735
• Villiger, P. M., Cronin, M. T., Amenomori, T., Wachsman, W., Lotz, M. IL-6 production by human T lymphocytes - expression in HTLV-1-infected but not in normal T-cells Journal of Immunology  1991 146:550-559  PMID:1987276
• Guerne, P. A., Lotz, M. Interleukin-6 and transforming growth-factor-beta synergistically stimulate chondrosarcoma cell-proliferation Journal of Cellular Physiology  1991 149:117-124  DOI:10.1002/jcp.1041490115  PMID:1939340
• Lotz, M., Guerne, P. A. Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases-1/erythroid potentiating activity (TIMP-1/EPA) Journal of Biological Chemistry  1991 266:2017-2020  PMID:1846608
• Kekow, J., Gross, W. L., Carson, D. A., Lotz, M. Modulation of immunocompetent cells in synovial-fluids by TGF-beta Immunitat und Infektion  1991 19:60-61  PMID:1677345
• Maisel, A. S., Murray, D., Lotz, M., Rearden, A., Irwin, M., Michel, M. C. Propranolol treatment affects parameters of human immunity Immunopharmacology  1991 22:157-164  DOI:10.1016/0162-3109(91)90040-6  PMID:1774156
• Kekow, J., Wachsman, W., McCutchan, J. A., Gross, W. L., Zachariah, M., Carson, D. A., Lotz, M. Transforming growth-factor-beta and suppression of humoral immune-responses in HIV-infection Journal of Clinical Investigation  1991 87:1010-1016  DOI:10.1172/jci115059  PMID:1999481
• Tighe, H., Silverman, G. J., Kozin, F., Tucker, R., Gulizia, R., Peebles, C., Lotz, M., Rhodes, G., Machold, K., Mosier, D. E., Carson, D. A. Autoantibody production by severe combined immunodeficient mice reconstituted with synovial cells from rheumatoid arthritis patients European Journal of Immunology  1990 20:1843-1848  DOI:10.1002/eji.1830200832  PMID:2209691
• Guerne, P. A., Carson, D. A., Lotz, M. IL-6 production by human articular chondrocytes - modulation of its synthesis by cytokines, growth-factors, and hormones in vitro Journal of Immunology  1990 144:499-505  PMID:2104896
• Carrera, C. J., Terai, C., Lotz, M., Curd, J. G., Piro, L. D., Beutler, E., Carson, D. A. Potent toxicity of 2-chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to immunosuppressive therapy Journal of Clinical Investigation  1990 86:1480-1488  DOI:10.1172/jci114865  PMID:1700795  PMCID:PMC296893
• Zuraw, B. L., Lotz, M. Regulation of the hepatic synthesis of C1 inhibitor by the hepatocyte stimulating factors interleukin-6 and interferon-gamma Journal of Biological Chemistry  1990 265:12664-12670  PMID:1695634
• Lotz, M., Kekow, J., Carson, D. A. Transforming growth-factor-beta and cellular immune-responses in synovial-fluids Journal of Immunology  1990 144:4189-4194  PMID:2187926
• Kekow, J., Wachsman, W., McCutchan, J. A., Cronin, M., Carson, D. A., Lotz, M. Transforming growth-factor-beta and noncytopathic mechanisms of immunodeficiency in human-immunodeficiency-virus infection Proceedings of the National Academy of Sciences of the United States of America  1990 87:8321-8325  DOI:10.1073/pnas.87.21.8321  PMID:1700428
• Jirik, F. R., Podor, T. J., Hirano, T., Kishimoto, T., Loskutoff, D. J., Carson, D. A., Lotz, M. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells Journal of Immunology  1989 142:144-147  PMID:2783321
• Lotz, M., Roudier, J. Epstein-Barr virus and rheumatoid-arthritis - cellular and molecular aspects Rheumatology International  1989 9:147-152  PMID:2481874
• Lotz, M., Zuraw, B. L., Carson, D. A., Jirik, F. R. Hepatocytes produce interleukin-6 Annals of the New York Academy of Sciences  1989 557:509-511  DOI:10.1111/j.1749-6632.1989.tb24048.x
• Podor, T. J., Jirik, F. R., Loskutoff, D. J., Carson, D. A., Lotz, M. Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6 Annals of the New York Academy of Sciences  1989 557:374-387  DOI:10.1111/j.1749-6632.1989.tb24030.x  PMID:2660697
• Guerne, P. A., Terkeltaub, R., Zuraw, B., Lotz, M. Inflammatory microcrystals stimulate interleukin-6 production and secretion by human-monocytes and synoviocytes Arthritis and Rheumatism  1989 32:1443-1452  DOI:10.1002/anr.1780321114  PMID:2554932
• Guerne, P. A., Vaughan, J. H., Carson, D. A., Terkeltaub, B., Lotz, M. Interleukin-6 (IL-6) and joint tissues Annals of the New York Academy of Sciences  1989 557:558-561  DOI:10.1111/j.1749-6632.1989.tb24065.x
• Guerne, P. A., Zuraw, B. L., Vaughan, J. H., Carson, D. A., Lotz, M. Synovium as a source of interleukin 6 in vitro - contribution to local and systemic manifestations of arthritis Journal of Clinical Investigation  1989 83:585-592  DOI:10.1172/jci113921  PMID:2464001
• Lotz, M., Jirik, F., Kabouridis, P., Tsoukas, C., Hirano, T., Kishimoto, T., Carson, D. A. B-cell stimulating factor-2/interleukin-6 is a costimulant for human thymocytes and lymphocytes-T Journal of Experimental Medicine  1988 167:1253-1258  DOI:10.1084/jem.167.3.1253  PMID:3127525
• Lotz, M., Vaughan, J. H., Carson, D. A. Effect of neuropeptides on production of inflammatory cytokines by human-monocytes Science  1988 241:1218-1221  DOI:10.1126/science.2457950  PMID:2457950
• Lotz, M., Tsoukas, C. D., Curd, J. G., Carson, D. A., Vaughan, J. H. Effects of recombinant human interferons on rheumatoid-arthritis lymphocytes-B activated by Epstein-Barr-virus Journal of Rheumatology  1987 14:42-45  PMID:3033238
• Lotz, M., Zuraw, B. L. Interferon-gamma is a major regulator of C1-inhibitor synthesis by human-blood monocytes Journal of Immunology  1987 139:3382-3387  PMID:3119706
• Kurki, P., Lotz, M., Ogata, K., Tan, E. M. Proliferating cell nuclear antigen (PCNA)/cyclin in activated human T lymphocytes Journal of Immunology  1987 138:4114-4120  PMID:2884260
• Lotz, M., Carson, D. A., Vaughan, J. H. Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis Science  1987 235:893-895  DOI:10.1126/science.2433770  PMID:2433770
• Lotz, M., Tsoukas, C. D., Robinson, C. A., Dinarello, C. A., Carson, D. A., Vaughan, J. H. Basis for defective responses of rheumatoid-arthritis synovial-fluid lymphocytes to anti-CD3 (T3) antibodies Journal of Clinical Investigation  1986 78:713-721  DOI:10.1172/jci112631  PMID:3091636
• Valentine, M., Lotz, M., Dinarello, C. A., Carson, D. A., Vaughan, J. H. Lymphoblastoid B-cell lines produce an interleukin-1-like activity that can be serologically distinct from macrophage interleukin-1 Lymphokine Research  1986 5:173-183  PMID:3018386
• Lotz, M., Tsoukas, C. D., Fong, S., Dinarello, C. A., Carson, D. A., Vaughan, J. H. Release of lymphokines after Epstein-Barr virus-infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in normal humans Journal of Immunology  1986 136:3636-3642  PMID:3009608
• Lotz, M., Tsoukas, C. D., Fong, S., Dinarello, C. A., Carson, D. A., Vaughan, J. H. Release of lymphokines after infection with Epstein-Barr-virus in vitro .2. A monocyte-dependent inhibitor of interleukin-1 down-regulates the production of interleukin-2 and interferon-gamma in rheumatoid-arthritis Journal of Immunology  1986 136:3643-3648  PMID:3009609
• Tsoukas, C. D., Landgraf, B., Bentin, J., Valentine, M., Lotz, M., Vaughan, J. H., Carson, D. A. Activation of resting lymphocytes-T by anti-CD3 (T3) antibodies in the absence of monocytes Journal of Immunology  1985 135:1719-1723  PMID:3926881
• Fox, R. I., Lotz, M., Rhodes, G., Vaughan, J. H. Epstein-Barr virus in rheumatoid-arthritis Clinics in Rheumatic Diseases  1985 11:665-688  PMID:3000687
• Lotz, M., Tsoukas, C. D., Fong, S., Carson, D. A., Vaughan, J. H. Regulation of Epstein-Barr virus-infection by recombinant interferons - selected sensitivity to interferon-gamma European Journal of Immunology  1985 15:520-525  DOI:10.1002/eji.1830150518  PMID:2581792
• Tsoukas, C. D., Valentine, M., Lotz, M., Vaughan, J. H., Carson, D. A. The role of the T3 molecular-complex on human lymphocyte-T mediated cyto-toxicity Advances in Experimental Medicine and Biology  1985 184:365-385  PMID:2931002
• Tsoukas, C. D., Lambris, J., Lotz, M., Valentine, M. A., Vaughan, J. H., Carson, D. A. Lymphocyte mitogenesis induced by monoclonal-antibodies to the T3-complex - differential modulation by human-IgG Cellular Immunology  1984 89:66-74  DOI:10.1016/0008-8749(84)90198-9  PMID:6207944
• Tsoukas, C. D., Valentine, M., Lotz, M., Vaughan, J. H., Carson, D. A. The role of the T3 molecular-complex in antigen recognition and subsequent activation events Immunology Today  1984 5:311-313  DOI:10.1016/0167-5699(84)90121-x  PMID:25290752