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Loring, Jeanne
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Loring, Jeanne

Faculty Member Emeritus
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Positions

  • 2019 - Professor Emeritus of Developmental Neurobiology, Molecular Medicine , Scripps Research
  • 2010 - Adjunct Professor, Department of Reproductive Medicine, School of Medicine, University of California, San Diego
  • 2007 - Adjunct Professor, Program in Stem Cells & Development,, Sanford Burnham Prebys Medical Discovery Institute
  • 2007 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2017 - 2019 Professor of Developmental Neurobiology, Molecular Medicine , Scripps Research
  • 2007 - 2017 Professor of Developmental Neurobiology, Chemical Physiology , Scripps Research
  • 2004 - 2007 Co-Director, Stem Cell Center, Sanford Burnham Prebys Medical Discovery Institute
  • 1997 - 2003 CSO and Founder, Arcos Bioscience
  • 1997 - 2001 Senior Director, Incyte Genomics
  • 1995 - 1997 Senior Research Fellow, Molecular Dynamics
  • 1989 - 1995 Senior Scientist, GenPharm International Inc.
  • 1987 - 1989 Staff Scientist, Hana Biologics, Inc.
  • 1982 - 1987 Assistant Professor/Lecturer, Embryology and Neurobiology, University of California, Davis
Dr. Loring’s research team melds stem cell biology and genomics. They are currently focused on three human disease areas. The project that is closest to clinical application is development of an autologous neuron replacement therapy for Parkinson’s disease, estimated to be in clinical trials in 2020. A second project focuses on multiple sclerosis, and is built on the observation that a specific hPSC-derived cell type produces factors that induce clinical recovery in a model of MS. The third project is relevant to autism, investigating the root causes of Fragile X syndrome (FXS) pathology by studying the development of human neurons using epigenetic, genomic, and physiological analysis. Her lab is also collaborating with the San Diego Zoo to use induced pluripotent stem cells from endangered species to aid in their conservation.

Research Areas research areas

  • Endangered species (LCSH)
  • Fragile X syndrome (LCSH)
  • Multiple sclerosis (LCSH)
  • Parkinson's disease

Contact

  • jloring@scripps.edu

Websites

  • Jeanne F. Loring, Ph.D.
  • Laboratory Website
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Publications

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  • 49

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    • Loring, J. F. Wind-down of stem-cell institute leaves a void Nature  2019 572:155-155  DOI:10.1038/d41586-019-02346-5  PMID:31391566
    • Kim, J. H., Alderton, A., Crook, J. M., Benvenisty, N., Brandsten, C., Firpo, M., Harrison, P. W., Kawamata, S., Kawase, E., Kurtz, A., Loring, J. F., Ludwig, T., et al. A Report from a Workshop of the International Stem Cell Banking Initiative, Held in Collaboration of Global Alliance for iPSC Therapies and the Harvard Stem Cell Institute, Boston, 2017 Stem Cells  2019 1130-1135  DOI:10.1002/stem.3003  PMID:31021472
    • Colunga, T., Hayworth, M., Kress, S., Reynolds, D. M., Chen, L., Nazor, K. L., Baur, J., Singh, A. M., Loring, J. F., Metzger, M., Dalton, S. Human pluripotent stem cell-derived multipotent vascular progenitors of the mesothelium lineage have utility in tissue engineering and repair Cell Reports  2019 26:2566-2579  DOI:10.1016/j.celrep.2019.02.016  PMID:30840882
    • Mangale, V., McIntyre, L. L., Walsh, C. M., Loring, J. F., Lane, T. E. Promoting remyelination through cell transplantation therapies in a model of viral-induced neurodegenerative disease Developmental Dynamics  2019 248:43-52  DOI:10.1002/dvdy.24658  PMID:30067309
    • Loring, J. F. Autologous induced pluripotent stem cell-derived neurons to treat Parkinson's disease Stem Cells and Development  2018  DOI:10.1089/scd.2018.0107  PMID:29790422
    • Allison, T. F., Andrews, P. W., Avior, Y., Barbaric, I., Benvenisty, N., Bock, C., Brehm, J., Brustle, O., Damjanov, I., Elefanty, A., Felkner, D., Gokhale, P. J., et al. Assessment of established techniques to determine developmental and malignant potential of human pluripotent stem cells Nature Communications  2018 9  DOI:10.1038/s41467-018-04011-3  PMID:29765017  PMCID:PMC5954055
    • Kurtz, A., Seltmann, S., Bairoch, A., Bittner, M. S., Bruce, K., Capes-Davis, A., Clarke, L., Crook, J. M., Daheron, L., Dewender, J., Faulconbridge, A., Fujibuchi, W., et al. A standard nomenclature for referencing and authentication of pluripotent stem cells Stem Cell Reports  2018 10:1-6  DOI:10.1016/j.stemcr.2017.12.002  PMID:29320760  PMCID:PMC5768986
    • Sugarman, J., Shivakumar, S., Rook, M., Loring, J. F., Rehmann-Sutter, C., Taupitz, J., Reinhard-Rupp, J., Hildemann, S. Ethical considerations in the manufacture, male, and distribution of genome editing technologies American Journal of Bioethics  2018 18:3-6  DOI:10.1080/15265161.2018.1489653  PMID:30133390
    • Panopoulos, A. D., D'Antonio, M., Benaglio, P., Williams, R., Hashem, S. I., Schuldt, B. M., DeBoever, C., Arias, A. D., Garcia, M., Nelson, B. C., Harismendy, O., Jakubosky, D. A., et al. iPSCORE: A resource of 222 iPSC lines enabling functional characterization of genetic variation across a variety of cell types Stem Cell Reports  2017 8:1086-1100  DOI:10.1016/j.stemcr.2017.03.012  PMID:28410642  PMCID:PMC5390244
    • Amir, H., Touboul, T., Sabatini, K., Chhabra, D., Garitaonandia, I., Loring, J. F., Morey, R., Laurent, L. C. Spontaneous single-copy loss of TP53 in human embryonic stem cells markedly increases cell proliferation and survival Stem Cells  2017 35:872-885  DOI:10.1002/stem.2550  PMID:27888558
    • Boland, M. J., Nazor, K. L., Tran, H. T., Szucs, A., Lynch, C. L., Paredes, R., Tassone, F., Sanna, P. P., Hagerman, R. J., Loring, J. F. Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome Brain  2017 140:582-598  DOI:10.1093/brain/aww357  PMID:28137726
    • O'Brien, C. M., Chy, H. S., Zhou, Q., Blumenfeld, S., Lambshead, J. W., Liu, X., Kie, J., Capaldo, B. D., Chung, T. L., Adams, T. E., Phan, T., Bentley, J. D., et al. New monoclonal antibodies to defined cell surface proteins on human pluripotent stem cells Stem Cells  2017 35:626-640  DOI:10.1002/stem.2558  PMID:28009074
    • Saragusty, J., Diecke, S., Drukker, M., Durrant, B., Friedrich Ben-Nun, I., Galli, C., Goritz, F., Hayashi, K., Hermes, R., Holtze, S., Johnson, S., Lazzari, G., et al. Rewinding the process of mammalian extinction Zoo Biology  2016 34:280-292  DOI:10.1002/zoo.21284  PMID:27142508
    • Peterson, S. E., Garitaonandia, I., Loring, J. F. The tumorigenic potential of pluripotent stem cells: What can we do to minimize it? Bioessays  2016 38:S86-S95  DOI:10.1002/bies.201670915  PMID:27417126
    • Plaisted, W. C., Zavala, A., Hingco, E., Tran, H., Coleman, R., Lane, T. E., Loring, J. F., Walsh, C. M. Remyelination is correlated with regulatory T Cell induction following human embryoid body-derived neural precursor cell transplantation in a viral model of multiple sclerosis PLoS One  2016 11  DOI:10.1371/journal.pone.0157620  PMID:27310015  PMCID:PMC4911106
    • Bhutani, K., Nazor, K. L., Williams, R., Tran, H., Dai, H., Dzakula, Z., Cho, E. H., Pang, A. W. C., Rao, M., Cao, H., Schork, N. J., Loring, J. F. Whole-genome mutational burden analysis of three pluripotency induction methods Nature Communications  2016 7  DOI:10.1038/ncomms10536  PMID:26892726  PMCID:PMC4762882
    • Zdravkovic, T., Nazor, K. L., Larocque, N., Gormley, M., Donne, M., Hunkapillar, N., Giritharan, G., Bernstein, H. S., Wei, G., Hebrok, M., Zeng, X., Genbacev, O., et al. Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification Development  2015 142:4010-4025  DOI:10.1242/dev.122846  PMID:26483210  PMCID:PMC4712832
    • Boroda, A. V., Zacharenko, P. G., Maiorova, M. A., Peterson, S. E., Loring, J. F., Odintsova, N. A. The first steps towards generating induced pluripotent stem cells from cryopreserved skin biopsies of marine mammals Russian Journal of Marine Biology  2015 41:405-408  DOI:10.1134/s106307401505003x
    • Wang, Y. C., Stein, J. W., Lynch, C. L., Tran, H. T., Lee, C. Y., Coleman, R., Hatch, A., Antontsev, V. G., Chy, H. S., O'Brien, C. M., Murthy, S. K., Laslett, A. L., et al. Glycosyltransferase ST6GAL1 contributes to the regulation of pluripotency in human pluripotent stem cells Scientific Reports  2015 5:13317  DOI:10.1038/srep13317  PMID:26304831  PMCID:PMC4548446
    • Rivera-Mulia, J. C., Buckley, Q., Sasaki, T., Zimmerman, J., Didier, R. A., Nazor, K., Loring, J. F., Lian, Z., Weissman, S., Robins, A. J., Schulz, T. C., Menendez, L., et al. Dynamic changes in replication timing and gene expression during lineage specification of human pluripotent stem cells Genome Research  2015 25:1091-1103  DOI:10.1101/gr.187989.114  PMID:26055160  PMCID:PMC4509994
    • Wang, Y. C., Lin, V., Loring, J. F., Peterson, S. E. The 'sweet' spot of cellular pluripotency: protein glycosylation in human pluripotent stem cells and its applications in regenerative medicine Expert Opinion on Biological Therapy  2015 15:679-687  DOI:10.1517/14712598.2015.1021329  PMID:25736263
    • French, A., Bravery, C., Smith, J., Chandra, A., Archibald, P., Gold, J. D., Artzi, N., Kim, H. W., Barker, R. W., Meissner, A., Wu, J. C., Knowles, J. C., et al. Enabling consistency in pluripotent stem cell-derived products for research and development and clinical applications through material standards Stem Cells Translational Medicine  2015 4:217-223  DOI:10.5966/sctm.2014-0233  PMID:25650438  PMCID:PMC4339854
    • Brandl, B., Schneider, S. A., Loring, J. F., Hardy, J., Gribbon, P., Muller, F. J. Stem cell reprogramming: basic implications and future perspective for movement disorders Movement Disorders  2015 30:301-312  DOI:10.1002/mds.26113  PMID:25546831
    • Garitaonandia, I., Amir, H., Boscolo, F. S., Wambua, G. K., Schultheisz, H. L., Sabatini, K., Morey, R., Waltz, S., Wang, Y. C., Tran, H., Leonardo, T. R., Nazor, K., et al. Increased risk of genetic and epigenetic instability in human embryonic stem cells associated with specific culture conditions PLoS One  2015 10:e0118307  DOI:10.1371/journal.pone.0118307  PMID:25714340  PMCID:PMC4340884
    • Jia, H., Morris, C. D., Williams, R. M., Loring, J. F., Thomas, E. A. HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation Proceedings of the National Academy of Sciences of the United States of America  2015 112:E56-E64  DOI:10.1073/pnas.1415195112  PMID:25535382  PMCID:PMC4291662
    • Gallego Romero, I., Pavlovic, B. J., Hernando-Herraez, I., Zhou, X., Ward, M. C., Banovich, N. E., Kagan, C. L., Burnett, J. E., Huang, C. H., Mitrano, A., Chavarria, C. I., Friedrich Ben-Nun, I., et al. A panel of induced pluripotent stem cells from chimpanzees: a resource for comparative functional genomics Elife  2015 4  DOI:10.7554/eLife.07103  PMID:26102527  PMCID:PMC4502404
    • Gomez, S., Castellano, G., Mayol, G., Sunol, M., Queiros, A., Bibikova, M., Nazor, K. L., Loring, J. F., Lemos, I., Rodriguez, E., De Torres, C., Mora, J., et al. DNA methylation fingerprint of neuroblastoma reveals new biological and clinical insights Epigenomics  2015 7:1137-1153  DOI:10.2217/epi.15.49  PMID:26067621
    • Andrews, P. W., Baker, D., Benvinisty, N., Miranda, B., Bruce, K., Brustle, O., Choi, M., Choi, Y. M., Crook, J. M., de Sousa, P. A., Dvorak, P., Freund, C., et al. Points to consider in the development of seed stocks of pluripotent stem cells for clinical applications: International Stem Cell Banking Initiative (ISCBI) Regenerative Medicine  2015 10:1-44  DOI:10.2217/rme.14.93  PMID:25675265
    • Nazor, K. L., Boland, M. J., Bibikova, M., Klotzle, B., Yu, M., Glenn-Pratola, V. L., Schell, J. P., Coleman, R. L., Cabral-da-Silva, M. C., Schmidt, U., Peterson, S. E., He, C., et al. Application of a low cost array-based technique - TAB-Array - for quantifying and mapping both 5mC and 5hmC at single base resolution in human pluripotent stem cells Genomics  2014 104:358-367  DOI:10.1016/j.ygeno.2014.08.014  PMID:25179373  PMCID:PMC4342188
    • Loring, J. F., McDevitt, T. C., Palecek, S. P., Schaffer, D. V., Zandstra, P. W., Nerem, R. M. A global assessment of stem cell engineering Tissue Engineering Part A  2014 20:2575-2589  DOI:10.1089/ten.tea.2013.0468  PMID:24428577  PMCID:PMC4195431
    • Soragni, E., Miao, W., Iudicello, M., Jacoby, D., De Mercanti, S., Clerico, M., Longo, F., Piga, A., Ku, S., Campau, E., Du, J., Penalver, P., et al. Epigenetic therapy for Friedreich ataxia Annals of Neurology  2014 76:489-508  DOI:10.1002/ana.24260  PMID:25159818  PMCID:PMC4361037
    • Marro, B. S., Blanc, C. A., Loring, J. F., Cahalan, M. D., Lane, T. E. Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies Expert Review of Neurotherapeutics  2014 14:1169-1179  DOI:10.1586/14737175.2014.955854  PMID:25245576  PMCID:PMC4232205
    • Muller, F. J., Loring, J. F. A compass for stem-cell differentiation Nature  2014 513:498-499  DOI:10.1038/nri3737  PMID:25234143  PMCID:PMC4191907
    • Wolfe, L. M., Thiagarajan, R. D., Boscolo, F., Tache, V., Coleman, R. L., Kim, J., Kwan, W. K., Loring, J. F., Parast, M., Laurent, L. C. Banking placental tissue: an optimized collection procedure for genome-wide analysis of nucleic acids Placenta  2014 35:645-654  DOI:10.1016/j.placenta.2014.05.005  PMID:24951174  PMCID:PMC4847722
    • Boland, M. J., Nazor, K. L., Loring, J. F. Epigenetic regulation of pluripotency and differentiation Circulation Research  2014 115:311-324  DOI:10.1161/circresaha.115.301517  PMID:24989490
    • Chen, C., Jiang, P., Xue, H., Peterson, S. E., Tran, H. T., McCann, A. E., Parast, M. M., Li, S., Pleasure, D. E., Laurent, L. C., Loring, J. F., Liu, Y., et al. Role of astroglia in Down's syndrome revealed by patient-derived human-induced pluripotent stem cells Nature Communications  2014 5:4430  DOI:10.1038/ncomms5430  PMID:25034944  PMCID:PMC4109022
    • Chen, L., Coleman, R., Leang, R., Tran, H., Kopf, A., Walsh, C. M., Sears-Kraxberger, I., Steward, O., Macklin, W. B., Loring, J. F., Lane, T. E. Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis Stem Cell Reports  2014 2:825-837  DOI:10.1016/j.stemcr.2014.04.005  PMID:24936469  PMCID:PMC4050357
    • Blurton-Jones, M., Spencer, B., Michael, S., Castello, N. A., Agazaryan, A. A., Davis, J. L., Muller, F. J., Loring, J. F., Masliah, E., LaFerla, F. M. Neural stem cells genetically-modified to express neprilysin reduce pathology in Alzheimer transgenic models Stem Cell Research & Therapy  2014 5:46  DOI:10.1186/scrt440  PMID:25022790  PMCID:PMC4055090
    • Peterson, S. E., Loring, J. F. Genomic instability in pluripotent stem cells: implications for clinical applications Journal of Biological Chemistry  2014 289:4578-4584  DOI:10.1074/jbc.R113.516419  PMID:24362040  PMCID:PMC3931019
    • Wang, Y. C., Peterson, S. E., Loring, J. F. Protein post-translational modifications and regulation of pluripotency in human stem cells Cell Research  2014 24:143-160  DOI:10.1038/cr.2013.151  PMID:24217768  PMCID:PMC3915910
    • Liao, X., Xue, H., Wang, Y. C., Nazor, K. L., Guo, S., Trivedi, N., Peterson, S. E., Liu, Y., Loring, J. F., Laurent, L. C. Matched miRNA and mRNA signatures from an hESC-based in vitro model of pancreatic differentiation reveal novel regulatory interactions Journal of Cell Science  2013 126:3848-3861  DOI:10.1242/jcs.123570  PMID:23813959  PMCID:PMC3757328
    • Jones, J. C., Sabatini, K., Liao, X., Tran, H. T., Lynch, C. L., Morey, R. E., Glenn-Pratola, V., Boscolo, F. S., Yang, Q., Parast, M. M., Liu, Y., Peterson, S. E., et al. Melanocytes derived from transgene-free human induced pluripotent stem cells Journal of Investigative Dermatology  2013 133:2104-2108  DOI:10.1038/jid.2013.139  PMID:23514962  PMCID:PMC3714355
    • Li, Y., Moretto-Zita, M., Soncin, F., Wakeland, A., Wolfe, L., Leon-Garcia, S., Pandian, R., Pizzo, D., Cui, L., Nazor, K., Loring, J. F., Crum, C. P., et al. BMP4-directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state Development  2013 140:3965-3976  DOI:10.1242/dev.092155  PMID:24004950  PMCID:PMC3775414
    • Kurian, L., Sancho-Martinez, I., Nivet, E., Aguirre, A., Moon, K., Pendaries, C., Volle-Challier, C., Bono, F., Herbert, J. M., Pulecio, J., Xia, Y., Li, M., et al. Conversion of human fibroblasts to angioblast-like progenitor cells Nature Methods  2013 10:77-83  DOI:10.1038/nmeth.2255  PMID:23202434  PMCID:PMC3531579
    • Fakunle, E. S., Loring, J. F. Ethnically diverse pluripotent stem cells for drug development Trends in Molecular Medicine  2012 18:709-716  DOI:10.1016/j.molmed.2012.10.007  PMID:23142148
    • Leonardo, T. R., Schultheisz, H. L., Loring, J. F., Laurent, L. C. The functions of micrornas in pluripotency and reprogramming Nature Cell Biology  2012 14:1114-1121  DOI:10.1038/ncb2613  PMID:23131918
    • Nazor, K. L., Loring, J. F., Laurent, L. C. Equally potent? Does cellular reprogramming justify the abandonment of human embryonic stem cells? EMBO Reports  2012 13:890-894  DOI:10.1038/embor.2012.134  PMID:22986548  PMCID:PMC3463969
    • Ramskold, D., Luo, S. J., Wang, Y. C., Li, R., Deng, Q. L., Faridani, O. R., Daniels, G. A., Khrebtukova, I., Loring, J. F., Laurent, L. C., Schroth, G. P., Sandberg, R. Full-length mrna-seq from single-cell levels of rna and individual circulating tumor cells Nature Biotechnology  2012 30:777-782  DOI:10.1038/nbt.2282  PMID:22820318  PMCID:PMC3467340
    • Nazor, K. L., Altun, G., Lynch, C., Tran, H., Harness, J. V., Slavin, I., Garitaonandia, I., Muller, F. J., Wang, Y. C., Boscolo, F. S., Fakunle, E., Dumevska, B., et al. Recurrent variations in DNA methylation in human pluripotent stem cells and their differentiated derivatives Cell Stem Cell  2012 10:620-634  DOI:10.1016/j.stem.2012.02.013  PMID:22560082  PMCID:PMC3348513
    • MacArthur, C. C., Xue, H. P., Van Hoof, D., Lieu, P. T., Dudas, M., Fontes, A., Swistowski, A., Touboul, T., Seerke, R., Laurent, L. C., Loring, J. F., German, M. S., et al. Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus Stem Cells and Development  2012 21:191-205  DOI:10.1089/scd.2011.0163  PMID:21699412  PMCID:PMC3258440
    • Wang, Y. C., Nakagawa, M., Garitaonandia, I., Slavin, I., Altun, G., Lacharite, R. M., Nazor, K. L., Tran, H. T., Lynch, C. L., Leonardo, T. R., Liu, Y., Peterson, S. E., et al. Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis Cell Research  2011 21:1551-1563  DOI:10.1038/cr.2011.148  PMID:21894191  PMCID:PMC3364725
    • Peterson, S. E., Tran, H. T., Garitaonandia, I., Han, S., Nickey, K. S., Leonardo, T., Laurent, L. C., Loring, J. F. Teratoma generation in the testis capsule Journal of Visualized Experiments : JoVE  2011 e3177  DOI:10.3791/3177  PMID:22158256  PMCID:PMC3308584
    • Sheridan, S. D., Theriault, K. M., Reis, S. A., Zhou, F., Madison, J. M., Daheron, L., Loring, J. F., Haggarty, S. J. Epigenetic characterization of the fmr1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile x syndrome PLoS One  2011 6:e26203  DOI:10.1371/journal.pone.0026203  PMID:22022567  PMCID:PMC3192166
    • Ben-Nun, I. F., Montague, S. C., Houck, M. L., Tran, H. T., Garitaonandia, I., Leonardo, T. R., Wang, Y. C., Charter, S. J., Laurent, L. C., Ryder, O. A., Loring, J. F. Induced pluripotent stem cells from highly endangered species Nature Methods  2011 8:829-831  DOI:10.1038/nmeth.1706  PMID:21892153
    • Golob, J. L., Kumar, R. M., Guenther, M. G., Pabon, L. M., Pratt, G. A., Loring, J. F., Laurent, L. C., Young, R. A., Murry, C. E. Evidence that gene activation and silencing during stem cell differentiation requires a transcriptionally paused intermediate state PLoS One  2011 6:e22416  DOI:10.1371/journal.pone.0022416  PMID:21886766  PMCID:PMC3158746
    • Peterson, S. E., Westra, J. W., Rehen, S. K., Young, H., Bushman, D. M., Paczkowski, C. M., Yung, Y. C., Lynch, C. L., Tran, H. T., Nickey, K. S., Wang, Y. C., Laurent, L. C., et al. Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy PLoS One  2011 6:e23018  DOI:10.1371/journal.pone.0023018  PMID:21857983  PMCID:PMC3156708
    • Liu, G. H., Suzuki, K., Qu, J., Sancho-Martinez, I., Yi, F., Li, M., Kumar, S., Nivet, E., Kim, J., Soligalla, R. D., Dubova, I., Goebl, A., et al. Targeted gene correction of laminopathy-associated lmna mutations in patient-specific ipscs Cell Stem Cell  2011 8:688-694  DOI:10.1016/j.stem.2011.04.019  PMID:21596650  PMCID:PMC3480729
    • Muller, F. J., Schuldt, B. M., Williams, R., Mason, D., Altun, G., Papapetrou, E. P., Danner, S., Goldmann, J. E., Herbst, A., Schmidt, N. O., Aldenhoff, J. B., Laurent, L. C., et al. A bioinformatic assay for pluripotency in human cells Nature Methods  2011 8:315-317  DOI:10.1038/nmeth.1580  PMID:21378979  PMCID:PMC3265323
    • Laurent, L. C., Ulitsky, I., Slavin, I., Tran, H., Schork, A., Morey, R., Lynch, C., Harness, J. V., Lee, S., Barrero, M. J., Ku, S., Martynova, M., et al. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture Cell Stem Cell  2011 8:106-118  DOI:10.1016/j.stem.2010.12.003  PMID:21211785  PMCID:PMC3043464
    • Harness, J. V., Turovets, N. A., Seiler, M. J., Nistor, G., Altun, G., Agapova, L. S., Ferguson, D., Laurent, L. C., Loring, J. F., Keirstead, H. S. Equivalence of conventionally-derived and parthenote-derived human embryonic stem cells PLoS One  2011 6:e14499  DOI:10.1371/journal.pone.0014499  PMID:21249129  PMCID:PMC3017547
    • Peterson, S. E., Chun, J., Loring, J. FISH analysis of human pluripotent stem cells Methods in Molecular Biology  2011 767:191-200  DOI:10.1007/978-1-61779-201-4_14  PMID:21822876
    • Ku, S., Soragni, E., Campau, E., Thomas, E. A., Altun, G., Laurent, L. C., Loring, J. F., Napierala, M., Gottesfeld, J. M. Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA.TTC triplet repeat instability Cell Stem Cell  2010 7:631-637  DOI:10.1016/j.stem.2010.09.014  PMID:21040903  PMCID:PMC2987635
    • Hansen, K., Muller, F. J., Messing, M., Zeigler, F., Loring, J. F., Lamszus, K., Westphal, M., Schmidt, N. O. A 3-dimensional extracellular matrix as a delivery system for the transplantation of glioma-targeting neural stem/progenitor cells Neuro-Oncology  2010 12:645-654  DOI:10.1093/neuonc/noq002  PMID:20156807  PMCID:PMC2940655
    • Abraham, S., Sheridan, S. D., Laurent, L. C., Albert, K., Stubban, C., Ulitsky, I., Miller, B., Loring, J. F., Rao, R. R. Propagation of human embryonic and induced pluripotent stem cells in an indirect co-culture system Biochemical and Biophysical Research Communications  2010 393:211-216  DOI:10.1016/j.bbrc.2010.01.101  PMID:20117095  PMCID:PMC2834855
    • Laurent, L., Wong, E., Li, G., Huynh, T., Tsirigos, A., Ong, C. T., Low, H. M., Sung, K. W. K., Rigoutsos, I., Loring, J., Wei, C. L. Dynamic changes in the human methylome during differentiation Genome Research  2010 20:320-331  DOI:10.1101/gr.101907.109  PMID:20133333  PMCID:PMC2840979
    • Altun, G., Loring, J. F., Laurent, L. C. DNA methylation in embryonic stem cells Journal of Cellular Biochemistry  2010 109:1-6  DOI:10.1002/jcb.22374  PMID:19899110  PMCID:PMC3289679
    • Laurent, L. C., Nievergelt, C. M., Lynch, C., Fakunle, E., Harness, J. V., Schmidt, U., Galat, V., Laslett, A. L., Otonkoski, T., Keirstead, H. S., Schork, A., Park, H. S., et al. Restricted ethnic diversity in human embryonic stem cell lines Nature Methods  2010 7:6-7  DOI:10.1038/nmeth0110-06  PMID:20038950
    • Blurton-Jones, M., Kitazawa, M., Martinez-Coria, H., Castello, N. A., Muller, F. J., Loring, J. F., Yamasaki, T. R., Poon, W. W., Green, K. N., LaFerla, F. M. Neural stem cells improve cognition via bdnf in a transgenic model of alzheimer disease Proceedings of the National Academy of Sciences of the United States of America  2009 106:13594-13599  DOI:10.1073/pnas.0901402106  PMID:19633196  PMCID:PMC2715325
    • Muller, F. J., Laurent, L. C., Kostka, D., Ulitsky, I., Williams, R., Lu, C., Park, I. H., Rao, M. S., Shamir, R., Schwartz, P. H., Schmidt, N. O., Loring, J. F. Regulatory networks define phenotypic classes of human stem cell lines Nature  2008 455:401-405  DOI:10.1038/nature07213  PMID:18724358  PMCID:PMC2637443
    • Laurent, L. C., Chen, J., Ulitsky, I., Mueller, F. J., Lu, C., Shamir, R., Fan, J. B., Loring, J. F. Comprehensive microrna profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequence Stem Cells  2008 26:1506-1516  DOI:10.1634/stemcells.2007-1081  PMID:18403753
    • Schwartz, P. H., Brick, D. J., Stover, A. E., Loring, J. F., Muller, F. J. Differentiation of neural lineage cells from human pluripotent stem cells Methods  2008 45:142-158  DOI:10.1016/j.ymeth.2008.03.007  PMID:18593611  PMCID:PMC2528840
    • Orlovskaya, I., Schraufstatter, I., Loring, J., Khaldoyanidi, S. Hematopoietic differentiation of embryonic stem cells Methods  2008 45:159-167  DOI:10.1016/j.ymeth.2008.03.002  PMID:18593612
    • West, M. D., Sargent, R. G., Long, J., Brown, C., Chu, J. S., Kessler, S., Derugin, N., Sampathkumar, J., Burrows, C., Vaziri, H., Williams, R., Chapman, K. B., et al. The actcellerate initiative: Large-scale combinatorial cloning of novel human embryonic stem cell derivatives Regenerative Medicine  2008 3:287-308  DOI:10.2217/17460751.3.3.287  PMID:18462054
    • Guibinga, G. H., Song, S. C., Loring, J., Friedmann, T. Characterization of the gene delivery properties of baculoviral-based virosomal vectors Journal of Virological Methods  2008 148:277-282  DOI:10.1016/j.jviromet.2007.11.007  PMID:18207578
    • Bibikova, M., Laurent, L. C., Ren, B., Loring, J. F., Fan, J. B. Unraveling epigenetic regulation in embryonic stem cells Cell Stem Cell  2008 2:123-134  DOI:10.1016/j.stem.2008.01.005  PMID:18371433
    • Serobyan, N., Jagannathan, S., Orlovskaya, I., Schraufstatter, I., Skok, M., Loring, J., Khaldoyanidi, S. The cholinergic system is involved in regulation of the development of the hematopoietic system Life Sciences  2007 80:2352-2360  DOI:10.1016/j.lfs.2007.04.017  PMID:17512954  PMCID:PMC2873871
    • Mueller, F. J., Serobyan, N., Schraufstatter, I. U., DiScipio, R., Wakeman, D., Loring, J. F., Snyder, E. Y., Khaldoyanidi, S. K. Adhesive interactions between human neural stem cells and inflamed human vascular endothelium are mediated by integrins Stem Cells  2006 24:2367-2372  DOI:10.1634/stemcells.2005-0568  PMID:17071855  PMCID:PMC2885956
    • Katkov, II, Kim, M. S., Bajpai, R., Altman, Y. S., Mercola, M., Loring, J. F., Terskikh, A. V., Snyder, E. Y., Levine, F. Cryopreservation by slow cooling with dmso diminished production of oct-4 pluripotency marker in human embryonic stem cells Cryobiology  2006 53:194-205  DOI:10.1016/j.cryobiol.2006.05.005  PMID:16839540
    • Bibikova, M., Chudin, E., Wu, B., Zhou, L. X., Garcia, E. W., Liu, Y., Shin, S., Plaia, T. W., Auerbach, J. M., Arking, D. E., Gonzalez, R., Crook, J., et al. Human embryonic stem cells have a unique epigenetic signature Genome Research  2006 16:1075-1083  DOI:10.1101/gr.5319906  PMID:16899657  PMCID:PMC1557765
    • Josephson, R., Sykes, G., Liu, Y., Ording, C., Xu, W. N., Zeng, X. M., Shin, S., Loring, J., Maitra, A., Rao, M. S., Auerbach, J. M. A molecular scheme for improved characterization of human embryonic stem cell lines BMC Biology  2006 4:28  DOI:10.1186/1741-7007-4-28  PMID:16919167  PMCID:PMC1601965
    • Liu, Y., Shin, S., Zeng, X., Zhan, M., Gonzalez, R., Mueller, F. J., Schwartz, C. M., Xue, H. P., Li, H., Baker, S. C., Chudin, E., Barker, D. L., et al. Genome wide profiling of human embryonic stem cells (hescs), their derivatives and embryonal carcinoma cells to develop base profiles of u.S. Federal government approved hesc lines BMC Developmental Biology  2006 6:20  DOI:10.1186/1471-213x/6/20  PMID:16672070
    • Li, H., Liu, Y., Shin, S., Sun, Y., Loring, J. F., Mattson, M. P., Rao, M. S., Zhan, M. Transcriptome coexpression map of human embryonic stem cells BMC Genomics  2006 7:103  DOI:10.1186/1471-2164-7-103  PMID:16670017  PMCID:PMC1523211
    • Cai, J. L., Chen, J., Liu, Y., Miura, T., Luo, Y. Q., Loring, J. F., Freed, W. J., Rao, M. S., Zeng, X. M. Assessing self-renewal and differentiation in human embryonic stem cell lines Stem Cells  2006 24:516-530  DOI:10.1634/stemcells.2005-0143  PMID:16293578  PMCID:PMC1855239
    • Muller, F. J., Snyder, E. Y., Loring, J. F. Gene therapy: Can neural stem cells deliver? Nature Reviews Neuroscience  2006 7:75-84  DOI:10.1038/nrn1829  PMID:16371952
    • Schwartz, C. M., Spivak, C. E., Baker, S. C., McDaniel, T. K., Loring, J. F., Nguyen, C., Chrest, F. J., Wersto, R., Arenas, E., Zeng, X. M., Freed, W. J., Rao, M. S. Ntera2: A model system to study dopaminergic differentiation of human embryonic stem cells Stem Cells and Development  2005 14:517-534  DOI:10.1089/scd.2005.14.517  PMID:16305337
    • Snyder, E. Y., Loring, J. E. A role for stem cell biology in the physiological and pathological aspects of aging Journal of the American Geriatrics Society  2005 53:S287-S291  DOI:10.1111/j.1532-5415.2005.53491.x  PMID:16131354
    • Dickey, C. A., Loring, J. F., Montgomery, J., Gordon, M. N., Eastman, P. S., Morgan, D. Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein plus presenilin-1 transgenic mice Journal of Neuroscience  2003 23:5219-5226  PMID:12832546
    • Loring, J. F., Wen, X., Lee, J. M., Seilhamer, J., Somogyi, R. A gene expression profile of alzheimer's disease DNA and Cell Biology  2001 20:683-695  DOI:10.1089/10445490152717541  PMID:11788046
    • Loring, J. F., Porter, J. G., Seilhamer, J., Kaser, M. R., Wesselschmidt, R. A gene expression profile of embryonic stem cells and embryonic stem cell-derived neurons Restorative Neurology and Neuroscience  2001 18:81-88  PMID:11847430
    • Hanzel, D. K., Trojanowski, J. Q., Johnston, R. F., Loring, J. F. High-throughput quantitative histological analysis of alzheimer's disease pathology using a confocal digital microscanner Nature Biotechnology  1999 17:53-57  DOI:10.1038/5225  PMID:9920269
    • Murai, H., Pierce, J. E. S., Raghupathi, R., Smith, D. H., Saatman, K. E., Trojanowski, J. Q., Lee, V. M. Y., Loring, J. F., Eckman, C., Younkin, S., McIntosh, T. K. Twofold overexpression of human beta-amyloid precursor proteins in transgenic mice does not affect the neuromotor, cognitive, or neurodegenerative sequelae following experimental brain injury Journal of Comparative Neurology  1998 392:428-438  DOI:10.1002/(sici)1096-9861(19980323)392:4<428::aid-cne2>3.0.co;2-2  PMID:9514508
    • Farese, R. V., Veniant, M. M., Cham, C. M., Flynn, L. M., Pierotti, V., Loring, J. F., Traber, M., Ruland, S., Stokowski, R. S., Huszar, D., Young, S. G. Phenotypic analysis of mice expressing exclusively apolipoprotein b48 or apolipoprotein b100 Proceedings of the National Academy of Sciences of the United States of America  1996 93:6393-6398  DOI:10.1073/pnas.93.13.6393  PMID:8692825
    • Loring, J. F., Paszty, C., Rose, A., McIntosh, T. K., Mural, H., Pierce, J. E. S., Schramm, S. R., Wymore, K., Lee, V. M. Y., Trojanowski, J. Q., Peterson, K. R. Rational design of an animal model for alzheimer's disease: Introduction of multiple human genomic transgenes to reproduce ad pathology in a rodent Neurobiology of Aging  1996 17:173-182  DOI:10.1016/0197-4580(95)02076-4  PMID:8744398
    • Paszty, C., Mohandas, N., Stevens, M. E., Loring, J. F., Liebhaber, S. A., Brion, C. M., Rubin, E. M. Lethal alpha-thalassemia created by gene targeting in mice and its genetic rescue Nature Genetics  1995 11:33-39  DOI:10.1038/ng0995-33  PMID:7550311
    • Buxbaum, J. D., Christensen, J. L., Ruefli, A. A., Greengard, P., Loring, J. F. Expression of APP in brains of transgenic mice containing the entire human APP gene Biochemical and Biophysical Research Communications  1993 197:639-645  DOI:10.1006/bbrc.1993.2527  PMID:8267600
    • Liu, C. P., Ueda, R., She, J. A., Sancho, J., Wang, B. P., Weddell, G., Loring, J., Kurahara, C., Dudley, E. C., Hayday, A., Terhorst, C., Huang, M. Abnormal T cell development in CD3-zeta-/- mutant mice and identification of a novel T cell population in the intestine EMBO Journal  1993 12:4863-4875  PMID:8223495  PMCID:PMC413941
    • Chen, J. Z., Trounstine, M., Alt, F. W., Young, F., Kurahara, C., Loring, J. F., Huszar, D. Immunoglobulin gene rearrangement in b-cell deficient mice generated by targeted deletion of the j(h) locus International Immunology  1993 5:647-656  DOI:10.1093/intimm/5.6.647  PMID:8347558
    • Chen, J. Z., Trounstine, M., Kurahara, C., Young, F., Kuo, C. C., Xu, Y., Loring, J. F., Alt, F. W., Huszar, D. B-cell development in mice that lack one or both immunoglobulin kappa-light chain genes EMBO Journal  1993 12:821-830  PMID:8458340  PMCID:PMC413279
    • Choi, T. K., Hollenbach, P. W., Pearson, B. E., Ueda, R. M., Weddell, G. N., Kurahara, C. G., Woodhouse, C. S., Kay, R. M., Loring, J. F. Transgenic mice containing a human heavy-chain immunoglobulin gene fragment cloned in a yeast artificial chromosome Nature Genetics  1993 4:117-123  DOI:10.1038/ng0693-117  PMID:8348148
    • Erickson, C. A., Loring, J. F., Lester, S. M. Migratory pathways of hnk-1-immunoreactive neural crest cells in the rat embryo Developmental Biology  1989 134:112-118  DOI:10.1016/0012-1606(89)90082-1  PMID:2659408
    • Strecker, R. E., Miao, R., Loring, J. F. Survival and function of aggregate cultures of rat fetal dopamine neurons grafted in a rat model of parkinsons-disease Experimental Brain Research  1989 76:315-322  PMID:2569985
    • Loring, J. F., Barker, D. L., Erickson, C. A. Migration and differentiation of neural crest and ventral neural tube cells in vitro: implications for in vitro and in vivo studies of the neural crest Journal of Neuroscience  1988 8:1001-1015  PMID:3346712
    • Loring, J. F., Erickson, C. A. Neural crest cell migratory pathways in the trunk of the chick-embryo Developmental Biology  1987 121:220-236  DOI:10.1016/0012-1606(87)90154-0  PMID:3552788
    • Cross, N. L., Loring, J. F., Harris, R. A novel form of sperm detachment from eggs of Urechis caupo Developmental Biology  1985 111:525-529  DOI:10.1016/0012-1606(85)90505-6
    • Murphy, A. D., Barker, D. L., Loring, J. F., Kater, S. B. Sprouting and functional regeneration of an identified serotonergic neuron following axotomy Journal of Neurobiology  1985 16:137-151  DOI:10.1002/neu.480160206  PMID:2985748
  • book

    • Nerem, R. M., Loring, J., McDevitt, T.C. and Palecek, S.P., Schaffer, D.V. and Zandstra, P.W. Stem cell engineering : a WTEC global assessment Science Policy Reports Springer 2014
    • Peterson, S., Loring, J. F. Human stem cell manual : a laboratory guide Oxford: Academic. 2012
    • Loring, J. F., Wesselschmidt, R. L., Schwartz, P. H. Human stem cell manual : a laboratory guide Amsterdam; Boston: Elsevier/Academic Press. 2007
  • patent

    • Compositions and Methods for Defining Cells United States patent US Patent 8,442,772 (PluriTest) (2013).
    • Alzheimer's Disease-associated Genes United States patent US Patent 6,682,888 (2004).
    • Down Syndrome Critical Region 1-Like 1 Proteins United States patent US Patent 6,524,819 (2003).
    • Transgenic Mouse Expressing Human Tau Gene United States patent US Patent  6,593,512 (2003).
    • Methods For Producing Recombinant Mammalian Cells Harboring A Yeast Artificial Chromosome United States patent US Patent 5,981,175 (1999).
  • thesis

    • Loring, J. F. Control of neural crest differentiation in vitro 1979

featured in

  • Renowned Researcher Jeanne Loring Heads New Stem Cell Center at Scripps Research  Newsletter
  • Scripps Research and GIS Scientists Map Epigenome of Human Stem Cells During Development: Billions of Data Points Provide Big Picture of "Human Epigenome" During Critical Developmental Window  News Release
  • Small RNAs May Play Big Role in Embryonic Stem Cells  Newsletter
  • Stemming the Tide  Article
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Teaching

advisees

  • graduate advising relationship

    • Zhang, Ai, Ph.D.  candidate, 2014 - 2019
    • Lee, Eveline, Ph.D.  candidate, 2013 - 2017
    • Nazor, Kristopher Lancaster, Ph.D.  candidate, 2009 - 2015
    • Coleman, Ronald, Ph.D.  candidate, 2006 - 2014
    • Schultheisz, Heather, Ph.D.  candidate, 2010 - 2013
  • postdoc or fellow advising relationship

    • Coleman, Ronald, Ph.D.  candidate, 2014 - 2017
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Background

education and training

  • Ph.D. in Developmental Neurobiology, University of Oregon , Institute of Molecular Biology 1979
  • B.S. in Molecular Biology, University of Washington , magna cum laude 1972

awards and honors

  • Benning Medical Society Lecturer, University of Utah, 2016
  • Stem Cell Action Advocacy Award, World Stem Cell Summit, 2015
  • Stem Cell Person of the Year, The Niche, 2015
  • Esther O’Keeffe Foundation Award for Stem Cell Research, 2010
  • Millipore Foundation Stem Cell Research Award, 2010
  • Marie and Jimmy Mayer Award for Melanoma Research, 2010
  • Esther O’Keeffe Foundation Award for Stem Cell Research, 2009
  • Marie Mayer Award for Melanoma Research, 2009
  • Millipore Foundation Award for Stem Cell Research, 2008
  • Burnham Institute for Medical Research Leadership Award, 2007
  • Korean Society of Developmental Biology, Commendation , 2006
  • San Diego Chapter of Clinical Research Professionals, Educational Award , 2006
  • Brandeis University National Women's Committee Award, 2005
  • National Institutes of Health Postdoctoral Fellowship, Neurobiology, 1980
  • National Institutes of Health Predoctoral Traineeship, Genetics, 1979
  • National Institutes of Health Predoctoral Traineeship, Genetics, 1978
  • National Science Foundation Predoctoral Fellowship, 1977
  • National Science Foundation Predoctoral Fellowship (individual award), 1973
  • National Merit Undergraduate Scholarship (Doherty Foundation), 1972
  • National Merit Undergraduate Scholarship (Doherty Foundation), 1968
  • Phi Beta Kappa
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Contact

full name

  • Jeanne Frances Loring

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-6226-9767

ResearcherID (Thomson Reuters)

  • A-1620-2011

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