Dr. Loring’s research team melds stem cell biology and genomics. They are currently focused on three human disease areas. The project that is closest to clinical application is development of an autologous neuron replacement therapy for Parkinson’s disease, estimated to be in clinical trials in 2020. A second project focuses on multiple sclerosis, and is built on the observation that a specific hPSC-derived cell type produces factors that induce clinical recovery in a model of MS. The third project is relevant to autism, investigating the root causes of Fragile X syndrome (FXS) pathology by studying the development of human neurons using epigenetic, genomic, and physiological analysis. Her lab is also collaborating with the San Diego Zoo to use induced pluripotent stem cells from endangered species to aid in their conservation.