LoGrasso, Philip

Person

Positions

2005 - Senior Scientific Director, Discovery Biology, Translational Research Institute , Scripps Research
Research Fellow, Merck & Co., Inc.
Program Director, National Institute of General Medical Sciences, National Institutes of Health
Director of Preclinical Research and Development, Avera Pharmaceuticals
2007 - 2017 Professor, Molecular Therapeutics , Scripps Research
2005 - 2017 Professor (Joint Appointment), Metabolism and Aging , Scripps Research

Dr. Philip LoGrasso studies structure function relationships of enzymes for drug discovery and development.

Research Areas

Drug Discovery (UMLS)

Publications
Research
Background
Contact
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recent publications

academic article
- Grassi, D., Howard, S., Zhou, M., Diaz-Perez, N., Urban, N. T., Guerrero-Given, D., Kamasawa, N., Volpicelli-Daley, L. A., LoGrasso, P., Lasmezas, C. I. Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America 2018 115:E2634-E2643 DOI:10.1073/pnas.1713849115 PMID:29487216
- Gao, S., Howard, S., Lograsso, P. V. Pharmacological inhibition of c-Jun N-terminal Kinase reduces food intake and sensitizes leptin's anorectic signaling actions Scientific Reports 2017 7 DOI:10.1038/srep41795 PMID:28165482 PMCID:PMC5292945
- Feng, Y. B., Lograsso, P. V., Defert, O., Li, R. Rho kinase (ROCK) inhibitors and their therapeutic potential Journal of Medicinal Chemistry 2016 59:2269-2300 DOI:10.1021/acs.jmedchem.5b00683 PMID:26486225
- Iqbal, S., Howard, S., Lograsso, P. V. Serum- and glucocorticoid-inducible kinase 1 confers protection in cell-based and in in vivo neurotoxin models via the c-Jun N-terminal kinase signaling pathway Molecular and Cellular Biology 2015 35:1992-2006 DOI:10.1128/mcb.01510-14 PMID:25825522
- Zheng, K., Park, C. M., Iqbal, S., Hernandez, P., Park, H., Lograsso, P. V., Feng, Y. Pyridopyrimidinone derivatives as potent and selective c-jun N-terminal kinase (JNK) inhibitors ACS Medicinal Chemistry Letters 2015 6:413-418 DOI:10.1021/ml500474d PMID:25893042 PMCID:PMC4394340
- Yin, Y., Zheng, K., Eid, N., Howard, S., Jeong, J. H., Yi, F., Guo, J., Park, C. M., Bibian, M., Wu, W., Hernandez, P., Park, H., et al. Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors Journal of Medicinal Chemistry 2015 58:1846-1861 DOI:10.1021/jm501680m PMID:25621531 PMCID:PMC4349585
- Park, H., Iqbal, S., Hernandez, P., Mora, R., Zheng, K., Feng, Y., LoGrasso, P. Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles Scientific Reports 2015 5 DOI:10.1038/srep08047 PMID:25623238 PMCID:PMC4306959
- Zheng, K., Iqbal, S., Hernandez, P., Park, H., Lograsso, P. V., Feng, Y. Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives Journal of Medicinal Chemistry 2014 57:10013-10030 DOI:10.1021/jm501256y PMID:25393557 PMCID:PMC4266361
- Feng, Y., Lograsso, P. V. Rho kinase inhibitors: a patent review (2012-2013) Expert Opinion on Therapeutic Patents 2014 24:295-307 DOI:10.1517/13543776.2014.863279 PMID:24283930
- He, Y., Duckett, D., Chen, W., Ling, Y. Y., Cameron, M. D., Lin, L., Ruiz, C. H., Lograsso, P. V., Kamenecka, T. M., Koenig, M. Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors Bioorganic & Medicinal Chemistry Letters 2014 24:161-164 DOI:10.1016/j.bmcl.2013.11.052 PMID:24332487 PMCID:PMC4540177
- Feng, Y. B., Chambers, J. W., Iqbal, S., Koenig, M., Park, H., Cherry, L., Hernandez, P., Figuera-Losada, M., Lograsso, P. V. A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases ACS Chemical Biology 2013 8:1747-1754 DOI:10.1021/cb3006165 PMID:23751758 PMCID:PMC3759981
- Feng, Y., Chambers, J. W., Iqbal, S., Koenig, M., Park, H., Cherry, L., Hernandez, P., Figuera-Losada, M., Lograsso, P. V. A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases ACS Chemical Biology 2013 8:1747-1754 DOI:10.1021/cb3006165 PMID:23751758 PMCID:PMC3759981
- Yin, Y., Lin, L., Ruiz, C., Khan, S., Cameron, M. D., Grant, W., Pocas, J., Eid, N., Park, H., Schroter, T., Lograsso, P. V., Feng, Y. Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors Journal of Medicinal Chemistry 2013 56:3568-3581 DOI:10.1021/jm400062r PMID:23570561
- Chowdhury, S., Chen, Y. T., Fang, X. G., Grant, W., Pocas, J., Cameron, M. D., Ruiz, C., Lin, L., Park, H., Schroter, T., Bannister, T. D., LoGrasso, P. V., et al. Amino acid derived quinazolines as Rock/PKA inhibitors Bioorganic & Medicinal Chemistry Letters 2013 23:1592-1599 DOI:10.1016/j.bmcl.2013.01.109 PMID:23416002
- Chambers, J. W., Pachori, A., Howard, S., Iqbal, S., LoGrasso, P. V. Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats Journal of Biological Chemistry 2013 288:4000-4011 DOI:10.1074/jbc.M112.406777 PMID:23258542 PMCID:PMC3567652
- Chambers, J. W., Howard, S., LoGrasso, P. V. Blocking c-jun n-terminal kinase (jnk) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo Journal of Biological Chemistry 2013 288:1079-1087 DOI:10.1074/jbc.M112.421354 PMID:23184940 PMCID:PMC3542993
- Jeso, V., Iqbal, S., Hernandez, P., Cameron, M. D., Park, H., Lograsso, P. V., Micalizio, G. C. Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid Angewandte Chemie-International Edition 2013 52:4800-4804 DOI:10.1002/anie.201301323 PMID:23554224
- Laughlin, J. D., Nwachukwu, J. C., Figuera-Losada, M., Cherry, L., Nettles, K. W., LoGrasso, P. V. Structural mechanisms of allostery and autoinhibition in JNK family kinases Structure 2012 20:2174-2184 DOI:10.1016/j.str.2012.09.021 PMID:23142346 PMCID:PMC3589125
- Boregowda, S. V., Krishnappa, V., Chambers, J. W., Lograsso, P. V., Lai, W. T., Ortiz, L. A., Phinney, D. G. Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53-dependent mechanism: Implications for long-term culture expansion Stem Cells 2012 30:975-987 DOI:10.1002/stem.1069 PMID:22367737 PMCID:PMC3683654
- Figuera-Losada, M., LoGrasso, P. V. Enzyme kinetics and interaction studies for human jnk1 beta 1 and substrates activating transcription factor 2 (atf2) and c-jun n-terminal kinase (c-jun) Journal of Biological Chemistry 2012 287:13291-13302 DOI:10.1074/jbc.M111.323766 PMID:22351776 PMCID:PMC3339953
- Zhang, T., Inesta-Vaquera, F., Niepel, M., Zhang, J. M., Ficarro, S. B., Machleidt, T., Xie, T., Marto, J. A., Kim, N., Sim, T., Laughlin, J. D., Park, H., et al. Discovery of potent and selective covalent inhibitors of JNK Chemistry & Biology 2012 19:140-154 DOI:10.1016/j.chembiol.2011.11.010 PMID:22284361 PMCID:PMC3270411
- Sessions, E. H., Chowdhury, S., Yin, Y., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., LoGrasso, P., Bannister, T. D., Feng, Y. B. Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II) Bioorganic & Medicinal Chemistry Letters 2011 21:7113-7118 DOI:10.1016/j.bmcl.2011.09.084 PMID:22018789
- Chowdhury, S., Sessions, E. H., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., Schurer, S., LoGrasso, P., Bannister, T. D., Feng, Y. B. Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I) Bioorganic & Medicinal Chemistry Letters 2011 21:7107-7112 DOI:10.1016/j.bmcl.2011.09.083 PMID:22004718
- Jeso, V., Cherry, L., Macklin, T. K., Pan, S. C., LoGrasso, P. V., Micalizio, G. C. Convergent synthesis and discovery of a natural product-inspired paralog-selective Hsp90 inhibitor Organic Letters 2011 13:5108-5111 DOI:10.1021/ol2019828 PMID:21866939
- Chambers, J. W., Cherry, L., Laughlin, J. D., Figuera-Losada, M., LoGrasso, P. V. Selective inhibition of mitochondrial jnk signaling achieved using peptide mimicry of the sab kinase interacting motif-1 (kim1) ACS Chemical Biology 2011 6:808-818 DOI:10.1021/cb200062a PMID:21563797 PMCID:PMC3158843
- Chambers, J. W., LoGrasso, P. V. Mitochondrial c-jun n-terminal kinase (jnk) signaling initiates physiological changes resulting in amplification of reactive oxygen species generation Journal of Biological Chemistry 2011 286:16052-16062 DOI:10.1074/jbc.M111.223602 PMID:21454558 PMCID:PMC3091214
- Noel, R., Shin, Y., Song, X. Y., He, Y. J., Koenig, M., Chen, W. M., Ling, Y. Y., Lin, L., Ruiz, C. H., LoGrasso, P., Cameron, M. D., Duckett, D. R., et al. Synthesis and SAR of 4-(pyrazol-3-yl)-pyridines as novel c-jun N-terminal kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2011 21:2732-2735 DOI:10.1016/j.bmcl.2010.11.104 PMID:21185177 PMCID:PMC3081976
- Crocker, C. E., Khan, S., Cameron, M. D., Robertson, H. A., Robertson, G. S., LoGrasso, P. JNK inhibition protects dopamine neurons and provides behavioral improvement in a rat 6-hydroxydopamine model of Parkinson's Disease ACS Chemical Neuroscience 2011 2:207-212 DOI:10.1021/cn1001107 PMID:21666838 PMCID:PMC3110072
- Chambers, J. W., Pachori, A., Howard, S., Ganno, M., Hansen, D., Song, X. Y., Kamenecka, T., Duckett, D., Chen, W. M., Ling, Y. Y., Cherry, L., Cameron, M. D. Small molecule c-jun-N-terminal Kinase (JNK) inhibitors protect dopaminergic neurons in a model of Parkinson's Disease ACS Chemical Neuroscience 2011 2:198-206 DOI:10.1021/cn100109k PMID:21666839 PMCID:PMC3110074
- He, Y. J., Kamenecka, T. M., Shin, Y. S., Song, X. Y., Jiang, R., Noel, R., Duckett, D., Chen, W. M., Ling, Y. Y., Cameron, M. D., Lin, L., Khan, S., et al. Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) inhibitors Bioorganic & Medicinal Chemistry Letters 2011 21:1719-1723 DOI:10.1016/j.bmcl.2011.01.079 PMID:21316221 PMCID:PMC3052630
- Fang, X. A., Chen, Y. T., Sessions, E. H., Chowdhury, S., Vojkovsky, T., Yin, Y., Pocas, J. R., Grant, W., Schroter, T., Lin, L., Ruiz, C., Cameron, M. D., et al. Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2011 21:1844-1848 DOI:10.1016/j.bmcl.2011.01.039 PMID:21349713
- Chen, Y. T., Vojkovsky, T., Fang, X. G., Pocas, J. R., Grant, W., Handy, A. M. W., Schroter, T., LoGrasso, P., Bannister, T. D., Fang, Y. B. Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors MedChemComm 2011 2:73-75 DOI:10.1039/c0md00194e
- Fang, X. G., Yin, Y., Chen, Y. T., Yao, L., Wang, B., Cameron, M. D., Lin, L., Khan, S., Ruiz, C., Schroter, T., Grant, W., Weiser, A., et al. Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors Journal of Medicinal Chemistry 2010 53:5727-5737 DOI:10.1021/jm100579r PMID:20684608
- Yin, Y., Cameron, M. D., Lin, L., Khan, S., Schroter, T., Grant, W., Pocas, J., Chen, Y. T., Schurer, S., Pachori, A., LoGrasso, P., Feng, Y. B. Discovery of potent and selective urea-based ROCK inhibitors and their effects on intraocular pressure in rats ACS Medicinal Chemistry Letters 2010 1:175-179 DOI:10.1021/ml1000382 PMID:24900192 PMCID:PMC4007833
- Sessions, E. H., Smolinski, M., Wang, B., Frackowiak, B., Chowdhury, S., Yin, Y., Chen, Y. T., Ruiz, C., Lin, L., Pocas, J., Schroter, T., Cameron, M. D., et al. The development of benzimidazoles as selective Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2010 20:1939-1943 DOI:10.1016/j.bmcl.2010.01.124 PMID:20167489
- Kamenecka, T., Jiang, R., Song, X. Y., Duckett, D., Chen, W. M., Ling, Y. Y., Habel, J., Laughlin, J. D., Chambers, J., Figuera-Losada, M., Cameron, M. D., Lin, L., et al. Synthesis, biological evaluation, X-ray structure, and pharmacokinetics of aminopyrimidine c-jun-N-terminal kinase (JNK) inhibitors Journal of Medicinal Chemistry 2010 53:419-431 DOI:10.1021/jm901351f PMID:19947601 PMCID:PMC2804074
- Yin, Y., Lin, L., Ruiz, C., Cameron, M. D., Pocas, J., Grant, W., Schroter, T., Chen, W. M., Duckett, D., Schurer, S., LoGrasso, P., Feng, Y. B. Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors Bioorganic & Medicinal Chemistry Letters 2009 19:6686-6690 DOI:10.1016/j.bmcl.2009.09.115 PMID:19837589
- Shin, Y. S., Chen, W. M., Habel, J., Duckett, D., Ling, Y. Y., Koenig, M., He, Y. J., Vojkovsky, T., LoGrasso, P., Kamenecka, T. M. Synthesis and sar of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors Bioorganic & Medicinal Chemistry Letters 2009 19:3344-3347 DOI:10.1016/j.bmcl.2009.03.086 PMID:19433357 PMCID:PMC2737472
- Kamenecka, T., Habel, J., Duckett, D., Chen, W. M., Ling, Y. Y., Frackowiak, B., Jiang, R., Shin, Y. S., Song, X. Y., LoGrasso, P. Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-jun N-terminal kinase 3 (JNK3) over p38 Journal of Biological Chemistry 2009 284:12853-12861 DOI:10.1074/jbc.M809430200 PMID:19261605 PMCID:PMC2676016
- LoGrasso, P. V., Feng, Y. B. Rho kinase (ROCK) inhibitors and their application to inflammatory disorders Current Topics in Medicinal Chemistry 2009 9:704-723 DOI:10.2174/156802609789044452 PMID:19689376
- Sessions, E. H., Yin, Y., Bannister, T. D., Weiser, A., Griffin, E., Pocas, J., Cameron, M. D., Ruiz, C., Lin, L., Schurer, S. C., Schroter, T., LoGrasso, P., et al. Benzimidazole- and benzoxazole-based inhibitors of Rho kinase Bioorganic & Medicinal Chemistry Letters 2008 18:6390-6393 DOI:10.1016/j.bmcl.2008.10.095 PMID:18996009
- Chen, Y. T., Bannister, T. D., Weiser, A., Griffin, E., Lin, L., Ruiz, C., Cameron, M. D., Schurer, S., Duckett, D., Schroter, T., LoGrasso, P., Feng, Y. B. Chroman-3-amides as potent Rho kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2008 18:6406-6409 DOI:10.1016/j.bmcl.2008.10.080 PMID:18990570
- Feng, Y. B., Yin, Y., Weiser, A., Griffin, E., Cameron, M. D., Lin, L., Ruiz, C., Schurer, S. C., Inoue, T., Rao, P. V., Schroter, T., LoGrasso, P. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors Journal of Medicinal Chemistry 2008 51:6642-6645 DOI:10.1021/jm800986w PMID:18834107 PMCID:PMC3708311
- Schroter, T., Griffin, E., Weiser, A., Feng, Y. B., LoGrasso, P. Detection of myosin light chain phosphorylation - a cell-based assay for screening rho-kinase inhibitors Biochemical and Biophysical Research Communications 2008 374:356-360 DOI:10.1016/j.bbrc.2008.07.028 PMID:18638453
- Ember, B., LoGrasso, P. Mechanistic characterization for c-jun-n-terminal kinase 1 alpha 1 Archives of Biochemistry and Biophysics 2008 477:324-329 DOI:10.1016/j.abb.2008.06.001 PMID:18559253
- LoGrasso, P., Kamenecka, T. Inhibitors of c-jun-n-terminal kinase (jnk) Mini-Reviews in Medicinal Chemistry 2008 8:755-766 DOI:10.2174/138955708784912120 PMID:18673131
- Ember, B., Kamenecka, T., LoGrasso, P. Kinetic mechanism and inhibitor characterization for c-jun-N-terminal kinase 3 alpha 1 Biochemistry 2008 47:3076-3084 DOI:10.1021/bi701852z PMID:18269248
- Schroeter, T., Minond, D., Weiser, A., Dao, C., Habel, J., Spicer, T., Chase, P., Baillargeon, P., Scampavia, L., Schuerer, S., Chung, C., Mader, C., et al. Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho-kinase II (ROCK-II) Journal of Biomolecular Screening 2008 13:17-28 DOI:10.1177/1087057107310806 PMID:18227223
- Jiang, R., Duckett, D., Chen, W., Habel, J., Ling, Y. Y., LoGrasso, P., Kamenecka, T. M. 3,5-disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors Bioorganic & Medicinal Chemistry Letters 2007 17:6378-6382 DOI:10.1016/j.bmcl.2007.08.054 PMID:17911023
- Feng, Y. B., Cameron, M. D., Frackowiak, B., Griffin, E., Lin, L., Ruiz, C., Schroter, T., LoGrasso, P. Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II Bioorganic & Medicinal Chemistry Letters 2007 17:2355-2360 DOI:10.1016/j.bmcl.2006.12.043 PMID:17368019
- Rech, J. C., Yato, M., Duckett, D., Ember, B., LoGrasso, P. V., Bergman, R. G., Ellman, J. A. Synthesis of potent bicyclic bisarylimidazole c-jun N-terminal kinase inhibitors by catalytic C-H bond activation Journal of the American Chemical Society 2007 129:490-491 DOI:10.1021/ja0676004 PMID:17227002 PMCID:PMC2556147
- Zhang, W. X., Wang, R. X., Wisniewski, D., Marcy, A. I., LoGrasso, P., Lisnock, J. M., Cummings, R. T., Thompson, J. E. Time-resolved Förster resonance energy transfer assays for the binding of nucleotide and protein substrates to p38 alpha protein kinase Analytical Biochemistry 2005 343:76-83 DOI:10.1016/j.ab.2005.05.011 PMID:15979553
- Fricker, M., LoGrasso, P., Ellis, S., Wilkie, N., Hunt, P., Pollack, S. J. Substituting c-jun n-terminal kinase-3 (jnk3) atp-binding site amino acid residues with their p38 counterparts affects binding of jnk- and p38-selective inhibitors Archives of Biochemistry and Biophysics 2005 438:195-205 DOI:10.1016/j.abb.2005.04.013 PMID:15907786
- LoGrasso, P., McKelvy, J. Advances in pain therapeutics Current Opinion in Chemical Biology 2003 7:452-456 DOI:10.1016/s1367-5931(03)00078-4 PMID:12941418
- Scapin, G., Patel, S. B., Lisnock, J., Becker, J. W., LoGrasso, P. V. The structure of jnk3 in complex with small molecule inhibitors: Structural basis for potency and selectivity Chemistry & Biology 2003 10:705-712 DOI:10.1016/s1074-5521(03)00159-5 PMID:12954329
- Trauger, J. W., Jiang, A., Stearns, B. A., LoGrasso, P. V. Kinetics of allopregnanolone formation catalyzed by human 3 alpha-hydroxysteroid dehydrogenase type iii (akrlc2) Biochemistry 2002 41:13451-13459 DOI:10.1021/bi026109w PMID:12416991
- Turner, M. S., Lin, F. F., Trauger, J. W., Stephens, J., LoGrasso, P. Characterization and purification of truncated human rho-kinase ii expressed in sf-21 cells Archives of Biochemistry and Biophysics 2002 405:13-20 DOI:10.1016/s0003-9861(02)00249-7 PMID:12176052
- Trauger, J. W., Lin, F. F., Turner, M. S., Stephens, J., LoGrasso, P. V. Kinetic mechanism for human rho-kinase ii (rock-ii) Biochemistry 2002 41:8948-8953 DOI:10.1021/bi0258243 PMID:12102637
- Harper, S. J., LoGrasso, P. Inhibitors of the JNK signaling pathway Drugs of the Future 2001 26:957-973 DOI:10.1358/dof.2001.026.10.858715
- Harper, S. J., LoGrasso, P. Signalling for survival and death in neurones - the role of stress-activated kinases, jnk and p38 Cellular Signalling 2001 13:299-310 DOI:10.1016/s0898-6568(01)00148-6 PMID:11369511
- Hawkins, J., Zheng, S., Frantz, B., LoGrasso, P. P38 map kinase substrate specificity differs greatly for protein and peptide substrates Archives of Biochemistry and Biophysics 2000 382:310-313 DOI:10.1006/abbi.2000.2005 PMID:11068883
- Lisnock, J., Griffin, P., Calaycay, J., Frantz, B., Parsons, J., O'Keefe, S. J., LoGrasso, P. Activation of JNK3 alpha 1 requires both MKK4 and MKK7: Kinetic characterization of in vitro phosphorylated JNK3 alpha 1 Biochemistry 2000 39:3141-3148 DOI:10.1021/bi992410+ PMID:10715136
- Wisniewski, D., LoGrasso, P., Calaycay, J., Marcy, A. Assay for i kappa b kinases using an in vivo biotinylated i kappa b protein substrate Analytical Biochemistry 1999 274:220-228 DOI:10.1006/abio.1999.4287 PMID:10527519
- Xue, S., Green, M. A., LoGrasso, P. V., Boettcher, B. R., Madison, E. L., Curtiss, L. K., Miles, L. A. Comparison of the effects of apo(a) kringle IV-10 and plasminogen kringles on the interactions of lipoprotein(a) with regulatory molecules Thrombosis and Haemostasis 1999 81:428-435 PMID:10102473
- Lisnock, J. M., Tebben, A., Frantz, B., O'Neill, E. A., Croft, G., O'Keefe, S. J., Li, B., Hacker, C., de Laszlo, S., Smith, A., Libby, B., Liverton, N., et al. Molecular basis for p38 protein kinase inhibitor specificity Biochemistry 1998 37:16573-16581 DOI:10.1021/bi981591x PMID:9843424
- LoGrasso, P. V., Frantz, B., Rolando, A. M., Okeefe, S. J., Hermes, J. D., Oneill, E. A. Kinetic mechanism for p38 map kinase Biochemistry 1997 36:10422-10427 DOI:10.1021/bi9706778 PMID:9265622
- LoGrasso, P. V., Hawkins, J., Frank, L. J., Wisniewski, D., Marcy, A. Mechanism of activation for zap-70 catalytic activity Proceedings of the National Academy of Sciences of the United States of America 1996 93:12165-12170 DOI:10.1073/pnas.93.22.12165 PMID:8901551
- Mikol, V., LoGrasso, P. V., Boettcher, B. R. Crystal structures of apolipoprotein(a) kringle iv37 free and complexed with 6-aminohexanoic acid and with p-aminomethylbenzoic acid: Existence of novel and expected binding modes Journal of Molecular Biology 1996 256:751-761 DOI:10.1006/jmbi.1996.0122 PMID:8642595
- Tu, C. K., Chen, X., Ren, X. L., Lograsso, P. V., Jewell, D. A., Laipis, P. J., Silverman, D. N. Interactions of active-site residues and catalytic activity of human carbonic anhydrase III Journal of Biological Chemistry 1994 269:23002-23006 PMID:8083199
- Lograsso, P. V., Cornellkennon, S., Boettcher, B. R. Comparison of the inhibition of yeast, rat, and human squalene synthetase Bioorganic Chemistry 1994 22:294-299 DOI:10.1006/bioo.1994.1023
- Lograsso, P. V., Cornellhennon, S., Boettcher, B. R. Cloning, expression, and characterization of human apolipoprotein(a) kringle iv37 Journal of Biological Chemistry 1994 269:21820-21827 PMID:8063825
- Lograsso, P. V., Soltis, D. A., Boettcher, B. R. Overexpression, purification, and kinetic characterization of a carboxyl-terminal-truncated yeast squalene synthetase Archives of Biochemistry and Biophysics 1993 307:193-199 DOI:10.1006/abbi.1993.1578 PMID:8239656
- Chen, X., Tu, C. K., Lograsso, P. V., Laipis, P. J., Silverman, D. N. Interaction and influence of phenylalanine-198 and threonine-199 on catalysis by human carbonic anhydrase III Biochemistry 1993 32:7861-7865 DOI:10.1021/bi00082a004 PMID:8347590
- Lograsso, P. V., Tu, C. K., Chen, X., Taoka, S. C., Laipis, P. J., Silverman, D. N. Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III Biochemistry 1993 32:5786-5791 DOI:10.1021/bi00073a010 PMID:8504098
- Lograsso, P. V., Tu, C. K., Jewell, D. A., Wynns, G. C., Laipis, P. J., Silverman, D. N. Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine Biochemistry 1991 30:8463-8470 DOI:10.1021/bi00098a025 PMID:1909176
- Jewell, D. A., Tu, C. K., Paranawithana, S. R., Tanhauser, S. M., Lograsso, P. V., Laipis, P. J., Silverman, D. N. Enhancement of the catalytic properties of human carbonic anhydrase-iii by site-directed mutagenesis Biochemistry 1991 30:1484-1490 DOI:10.1021/bi00220a006 PMID:1899618
- Tu, C. K., Paranawithana, S. R., Jewell, D. A., Tanhauser, S. M., Lograsso, P. V., Wynns, G. C., Laipis, P. J., Silverman, D. N. Buffer enhancement of proton-transfer in catalysis by human carbonic anhydrase-iii Biochemistry 1990 29:6400-6405 DOI:10.1021/bi00479a009 PMID:2169869
- Lograsso, P. V., Nicholson, L. K., Cross, T. A. N-h bond length determinations and implications for the gramicidin channel conformation and dynamics from n-15-h-1 dipolar interactions Journal of the American Chemical Society 1989 111:1910-1912 DOI:10.1021/ja00187a072
- Nicholson, L. K., Lograsso, P. V., Cross, T. A. Experimental-observation of orientational dispersion in the peptide backbone of the gramicidin cation channel Journal of the American Chemical Society 1989 111:400-401 DOI:10.1021/ja00183a077
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