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Lo, Chih-Hung Larry
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Lo, Chih-Hung Larry

Graduate Student
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Positions

  • 2016 - Senior Director of Research & Development, Corvidia Therapeutics
  • 2013 - 2015 Director of Global Biomarker Discovery and Development, Biogen
  • 2010 - 2013 Associate Director, Lead Development, Human Genome Sciences
  • 2001 - 2002 Scientist, Antibody Discovery and Development, Human Genome Sciences
  • 1999 - 2001 Scientist, MedImmune
  • 1998 - 1999 Assistant Professor, Scripps Research
  • 1995 - 1998 Scientific Associate, Scripps Research

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Publications

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  • academic article

    • Meylan, F., Song, Y. J., Fuss, I., Villarreal, S., Kahle, E., Malm, I. J., Acharya, K., Ramos, H. L., Lo, L., Mentink-Kane, M. M., Wynn, T. A., Migone, T. S., et al. The TNF-family cytokine TL1A drives IL-13-dependent small intestinal inflammation Mucosal Immunology  2011 4:172-185  DOI:10.1038/mi.2010.67  PMID:20980995  PMCID:PMC3437258
    • Migone, T. S., Subramanian, G. M., Zhong, J., Healey, L. M., Corey, A., Devalaraja, M., Lo, L., Ullrich, S., Zimmerman, J., Chen, A., Lewis, M., Meister, G., et al. Raxibacumab for the treatment of inhalational anthrax New England Journal of Medicine  2009 361:135-144  DOI:10.1056/NEJMoa0810603  PMID:19587338
    • Hotte, S. J., Hirte, H. W., Chen, E. X., Siu, L. L., Le, L. H., Corey, A., Iacobucci, A., MacLean, M., Lo, L., Fox, N. L., Oza, A. M. A phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies Clinical Cancer Research  2008 14:3450-3455  DOI:10.1158/1078-0432.ccr-07-1416  PMID:18519776
    • Greco, F. A., Bonomi, P., Crawford, J., Kelly, K., Oh, Y., Halpern, W., Lo, L., Gallant, G., Klein, J. Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer Lung Cancer  2008 61:82-90  DOI:10.1016/j.lungcan.2007.12.011  PMID:18255187
    • Gao, C., Mao, S. L., Lo, C. H. L., Wirsching, P., Lerner, R. A., Janda, K. D. Making artificial antibodies: A format for phage display of combinatorial heterodimeric arrays Proceedings of the National Academy of Sciences of the United States of America  1999 96:6025-6030  DOI:10.1073/pnas.96.11.6025  PMID:10339535
    • Mao, S. L., Gao, C., Lo, C. H. L., Wirsching, P., Wong, C. H., Janda, K. D. Phage-display library selection of high-affinity human single-chain antibodies to tumor-associated carbohydrate antigens sialyl Lewis(x) and Lewis(x) Proceedings of the National Academy of Sciences of the United States of America  1999 96:6953-6958  DOI:10.1073/pnas.96.12.6953  PMID:10359820
    • Gao, C., Lavey, B. J., Lo, C. H. L., Datta, A., Wentworth, P., Janda, K. D. Direct selection for catalysis from combinatorial antibody libraries using a boronic acid probe: Primary amide bond hydrolysis Journal of the American Chemical Society  1998 120:2211-2217  DOI:10.1021/ja9720220
    • Janda, K. D., Lo, L. C., Lo, C. H. L., Sim, M. M., Wang, R., Wong, C. H., Lerner, R. A. Chemical selection for catalysis in combinatorial antibody libraries Science  1997 275:945-948  DOI:10.1126/science.275.5302.945  PMID:9020070
    • Gao, C., Lo, C. H. L., Mao, S., Wirsching, P., Lerner, R. A., Janda, K. D., Lin, C. H. Making chemistry selectable by linking it to infectivity Proceedings of the National Academy of Sciences of the United States of America  1997 94:11777-11782  DOI:10.1073/pnas.94.22.11777  PMID:9342313
    • Lo, C. H. L., Wentworth, P., Jung, K. W., Yoon, J., Ashley, J. A., Janda, K. D. Reactive immunization strategy generates antibodies with high catalytic proficiencies Journal of the American Chemical Society  1997 119:10251-10252  DOI:10.1021/ja971442m
    • Lo, L. C., Lo, C. H. L., Janda, K. D., Kassel, D. B., Raushel, F. M. A versatile mechanism based reaction probe for the direct selection of biocatalysts Bioorganic & Medicinal Chemistry Letters  1996 6:2117-2120  DOI:10.1016/0960-894x(96)00379-4
    • Yli-Kauhaluoma, J. T., Ashley, J. A., Lo, C. H. L., Coakley, J., Wirsching, P., Janda, K. D. Catalytic antibodies with peptidyl-prolyl cis-trans isomerase activity Journal of the American Chemical Society  1996 118:5496-5497  DOI:10.1021/ja954206p
    • Lo, C. H. L., Gao, C., Mao, S. L., Matsui, K., Lerner, R. A., Janda, K. D. Chain shuffling: Investigations into the specificity and selectivity of antibody catalysis Israel Journal of Chemistry  1996 36:195-198
    • degree-related publication Yli-Kauhaluoma, J. T., Ashley, J. A., Lo, C. H., Tucker, L., Wolfe, M. M., Janda, K. D. Anti-metallocene antibodies: A new approach to enantioselective catalysis of the Diels-Alder reaction Journal of the American Chemical Society  1995 117:7041-7047  DOI:10.1021/ja00132a001
    • degree-related publication Wirsching, P., Ashley, J. A., Lo, C. H. L., Janda, K. D., Lerner, R. A. Reactive immunization Science  1995 270:1775-1782  DOI:10.1126/science.270.5243.1775  PMID:8525366
    • degree-related publication Janda, K. D.*, Lo, C. H. L.*, Li, T. Y., Barbas, C. F., Wirsching, P., Lerner, R. A. Direct selection for a catalytic mechanism from combinatorial antibody libraries Proceedings of the National Academy of Sciences of the United States of America  1994 91:2532-2536  DOI:10.1073/pnas.91.7.2532  PMID:8146149 (* = equal contribution)
    • degree-related publication Ashley, J. A., Lo, C. H. L., McElhaney, G. P., Wirsching, P., Janda, K. D. A catalytic antibody model for plp-dependent decarboxylases Journal of the American Chemical Society  1993 115:2515-2516  DOI:10.1021/ja00059a061
    • Chiou, S. H.*, Lo, C. H.*, Chang, C. Y., Itoh, T., Kaji, H., Samejima, T. Ostrich crystallins. Structural characterization of delta-crystallin with enzymic activity Biochemical Journal  1991 273:295-300  PMID:1991029  PMCID:PMC1149845 (* = equal contribution)
    • Lo, C. H., Chiou, S. H. Simple fractionation of phospholipase A2 analogues from snake venom by high-performance liquid chromatography Journal of Chromatography-Biomedical Applications  1990 530:129-136  DOI:10.1016/s0378-4347(00)82311-7  PMID:2277102
    • Chiou, S. H., Chang, W. P., Lo, C. H. Biochemical comparison of lens crystallins from three reptilian species Biochimica et Biophysica Acta  1988 955:1-9  DOI:10.1016/0167-4838(88)90173-2  PMID:3382668
    • Chiou, S. H., Chang, W. P., Chen, S. W., Lo, C. H. N-terminal sequences of gamma-crystallins from the amphibian lens and their homology with gamma-crystallins of other major classes of vertebrates International Journal of Peptide and Protein Research  1988 31:335-338  PMID:3259558
    • Chiou, S. H., Chang, W. P., Lo, C. H., Chen, S. W. Sequence comparison of gamma-crystallins from the reptilian and other vertebrate species FEBS Letters  1987 221:134-138  DOI:10.1016/0014-5793(87)80367-8  PMID:3622758
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Background

education and training

  • Ph.D. in Biology, Scripps Research 1990 - 1995
  • B.S. in Chemistry, National Taiwan University 1983 - 1987

advisee of

  • graduate advising relationship

    • Janda, Kim, Ph.D.  candidacy, 1991 - 1995
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Contact

full name

  • Chih-Hung Larry Lo

geographic location

  • Scripps California 

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