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Liu, Zhen

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  • Liu, Z., Li, X., Zeng, T., Engle, K. M. Directed, palladium(II)-catalyzed enantioselective anti-carboboration of alkenyl carbonyl compounds ACS Catalysis  2019 9:3260-3265  DOI:10.1021/acscatal.9b00181
  • Liu, Z., Chen, J., Lu, H. X., Li, X., Gao, Y., Coombs, J. R., Goldfogel, M. J., Engle, K. M. Palladium(0)-catalyzed directed syn-1,2-carboboration and -silylation: alkene scope, applications in dearomatization, and stereocontrol by a chiral auxiliary Angewandte Chemie-International Edition  2019  DOI:10.1002/anie.201910304  PMID:31538388
  • Liu, Z., Gao, Y., Zeng, T., Engle, K. M. Transition-metal-catalyzed 1,2-carboboration of alkenes: strategies, mechanisms, and stereocontrol Israel Journal of Chemistry  2019  DOI:10.1002/ijch.201900087
  • Liu, Z., Ni, H. Q., Zeng, T., Engle, K. M. Catalytic carbo- and aminoboration of alkenyl carbonyl compounds via five- and six-membered palladacycles Journal of the American Chemical Society  2018 140:3223-3227  DOI:10.1021/jacs.8b00881  PMID:29384373
  • Gao, D. W., Xiao, Y., Liu, M., Liu, Z., Karunananda, M. K., Chen, J. S., Engle, K. M. Catalytic, enantioselective synthesis of allenyl boronates ACS Catalysis  2018 8:3650-3654  DOI:10.1021/acscatal.8b00626
  • Zeng, T., Liu, Z., Schmidt, M. A., Eastgate, M. D., Engle, K. M. Directed, palladium(II)-catalyzed intermolecular aminohydroxylation of alkenes using a mild oxidation system Organic Letters  2018 20:3853-3857  DOI:10.1021/acs.orglett.8b01440  PMID:29888604  PMCID:PMC6039249
  • Liu, Z., Wang, Y., Wang, Z., Zeng, T., Liu, P., Engle, K. M. Catalytic intermolecular carboamination of unactivated alkenes via directed aminopalladation Journal of the American Chemical Society  2017 139:11261-11270  DOI:10.1021/jacs.7b06520  PMID:28727452
  • Derosa, J., Cantu, A. L., Boulous, M. N., O'Duill, M. L., Turnbull, J. L., Liu, Z., De La Torre, D. M., Engle, K. M. Palladium(II)-catalyzed directed anti-hydrochlorination of unactivated alkynes with HCl Journal of the American Chemical Society  2017 139:5183-5193  DOI:10.1021/jacs.7b00892  PMID:28266849
  • Yang, K. S., Gurak Jr., J. A., Liu, Z., Engle, K. M. Catalytic, regioselective hydrocarbofunctionalization of unactivated alkenes with diverse C-H nucleophiles Journal of the American Chemical Society  2016 138:14705-14712  DOI:10.1021/jacs.6b08850  PMID:27709911
  • Gurak, J. A., Yang, K. S., Liu, Z., Engle, K. M. Directed, regiocontrolled hydroamination of unactivated alkenes via protodepalladation Journal of the American Chemical Society  2016 138:5805-5808  DOI:10.1021/jacs.6b02718  PMID:27093112
  • Liu, Z., Derosa, J., Engle, K. M. Palladium(II)-catalyzed regioselective syn-hydroarylation of disubstituted alkynes using a removable directing group Journal of the American Chemical Society  2016 138:13076-13081  DOI:10.1021/jacs.6b08818  PMID:27602748
  • Liu, Z., Xia, Y., Feng, S., Zhang, Y., Wang, J. Rh(I)-Catalyzed coupling of 2-bromoethyl aryldiazoacetates with tertiary propargyl alcohols through carbene migratory insertion Organic Chemistry Frontiers  2016 3:1691-1698  DOI:10.1039/c6qo00453a
  • Feng, S., Mo, F., Xia, Y., Liu, Z., Liu, Z., Zhang, Y., Wang, J. Rhodium(I)-Catalyzed C-C Bond Activation of Siloxyvinylcyclopropanes with Diazoesters Angewandte Chemie-International Edition  2016 55:15401-15405  DOI:10.1002/anie.201609642  PMID:27862772
  • Liu, Z., Zeng, T., Yang, K. S., Engle, K. M. β,γ-vicinal dicarbofunctionalization of alkenyl carbonyl compounds via directed nucleopalladation Journal of the American Chemical Society  2016 138:15122-15125  DOI:10.1021/jacs.6b09170  PMID:27779861
  • Xia, Y., Liu, Z., Feng, S., Zhang, Y., Wang, J. Ir(III)-catalyzed aromatic C-H bond functionalization via metal carbene migratory insertion Journal of Organic Chemistry  2015 80:223-236  DOI:10.1021/jo5023102  PMID:25437770
  • Xia, Y., Ge, R., Chen, L., Liu, Z., Xiao, Q., Zhang, Y., Wang, J. Palladium-catalyzed oxidative cross-coupling of conjugated enynones with organoboronic acids Journal of Organic Chemistry  2015 80:7856-7864  DOI:10.1021/acs.joc.5b01350  PMID:26219829
  • Xia, Y., Liu, Z., Ge, R., Xiao, Q., Zhang, Y., Wang, J. Pd-catalyzed cross-coupling of terminal alkynes with ene-yne-ketones: access to conjugated enynes via metal carbene migratory insertion Chemical Communications  2015 51:11233-11235  DOI:10.1039/c5cc03559g  PMID:26077197
  • Xia, Y., Liu, Z., Feng, S., Ye, F., Zhang, Y., Wang, J. Rh(I)-catalyzed cross-coupling of α-diazoesters with arylsiloxanes Organic Letters  2015 17:956-959  DOI:10.1021/acs.orglett.5b00052  PMID:25671642
  • Liu, Z., Xia, Y., Feng, S., Wang, S., Qiu, D., Zhang, Y., Wang, J. Rh-I-catalyzed Stille-type coupling of diazoesters with aryl trimethylstannanes Australian Journal of Chemistry  2015 68:1379-1384  DOI:10.1071/ch15218
  • Xia, Y., Feng, S., Liu, Z., Zhang, Y., Wang, J. Rhodium(I)-catalyzed sequential C(sp)C(sp(3)) and C(sp(3))C(sp(3)) bond formation through migratory carbene insertion Angewandte Chemie-International Edition  2015 54:7891-7894  DOI:10.1002/anie.201503140  PMID:25982105
  • Xia, Y., Liu, Z., Liu, Z., Ge, R., Ye, F., Hossain, M., Zhang, Y., Wang, J. Formal carbene insertion into C-C bond: Rh(I)-catalyzed reaction of benzocyclobutenols with diazoesters Journal of the American Chemical Society  2014 136:3013-3015  DOI:10.1021/ja500118w  PMID:24512084
  • Xia, Y., Xia, Y., Ge, R., Liu, Z., Xiao, Q., Zhang, Y., Wang, J. Oxidative cross-coupling of allenyl ketones and organoboronic acids: expeditious synthesis of highly substituted furans Angewandte Chemie-International Edition  2014 53:3917-3921  DOI:10.1002/anie.201400500  PMID:24615951
  • Xia, Y., Xia, Y., Liu, Z., Zhang, Y., Wang, J. Palladium-catalyzed cross-coupling reaction of diazo compounds and vinyl boronic acids: an approach to 1,3-diene compounds Journal of Organic Chemistry  2014 79:7711-7717  DOI:10.1021/jo5012703  PMID:25019414
  • Xia, Y., Qu, S., Xiao, Q., Wang, Z. X., Qu, P. Y., Chen, L., Liu, Z., Tian, L., Huang, Z., Zhang, Y., Wang, J. Palladium-catalyzed carbene migratory insertion using conjugated ene-yne-ketones as carbene precursors Journal of the American Chemical Society  2013 135:13502-13511  DOI:10.1021/ja4058844  PMID:23947689

Background

education and training

• Ph.D. in Chemistry, Scripps Research 2015 - 2019
• B.S. in Chemistry, Peking University 2012 - 2015

advisee of

• graduate advising relationship

  • Engle, Keary M., Ph.D.  candidacy, 2016 - 2019

Contact

full name

• Zhen Liu

geographic location

• Scripps California 

Identity

ORCID iD

• http://orcid.org/0000-0002-1119-0693