recent publications
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academic article
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Naydenov, A. V., Horne, E. A., Cheah, C. S., Swinney, K., Hsu, K. L., Cao, J. K., Marrs, W. R., Blankman, J. L., Tu, S., Cherry, A. E., Fung, S., Wen, A., et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice Neuron 2014 83:361-371 DOI:10.1016/j.neuron.2014.06.030 PMID:25033180 PMCID:PMC4136499
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Dominguez, E., Galmozzi, A., Chang, J. W., Hsu, K. L., Pawlak, J., Li, W., Godio, C., Thomas, J., Partida, D., Niessen, S., O'Brien, P. E., Russell, A. P., et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes Nature Chemical Biology 2014 10:113-121 DOI:10.1038/nchembio.1429 PMID:24362705 PMCID:PMC3953460
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Holly, S. P., Chang, J. W., Li, W. W., Niessen, S., Phillips, R. M., Piatt, R., Black, J. L., Smith, M. C., Boulaftali, Y., Weyrich, A. S., Bergmeier, W., Cravatt, B. F., et al. Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation Chemistry & Biology 2013 20:1125-1134 DOI:10.1016/j.chembiol.2013.07.011 PMID:23993462 PMCID:PMC3948353
- Xu, H., Feely, S. L., Wang, X., Liu, D. X., Borda, J. T., Dufour, J., Li, W., Aye, P. P., Doxiadis, G. G., Khosla, C., Veazey, R. S., Sestak, K. Gluten-sensitive enteropathy coincides with decreased capability of intestinal T cells to secrete IL-17 and IL-22 in a macaque model for celiac disease Clinical Immunology 2013 147:40-49 DOI:10.1016/j.clim.2013.02.012 PMID:23518597 PMCID:PMC3732447
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Bachovchin, D. A., Ji, T. Y., Li, W. W., Simon, G. M., Blankman, J. L., Adibekian, A., Hoover, H., Niessen, S., Cravatt, B. F. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening Proceedings of the National Academy of Sciences of the United States of America 2010 107:20941-20946 DOI:10.1073/pnas.1011663107 PMID:21084632 PMCID:PMC3000285
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Marrs, W. R., Blankman, J. L., Horne, E. A., Thomazeau, A., Lin, Y. H., Coy, J., Bodor, A. L., Muccioli, G. G., Hu, S. S. J., Woodruff, G., Fung, S., Lafourcade, M., et al. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors Nature Neuroscience 2010 13:951-957 DOI:10.1038/nn.2601 PMID:20657592 PMCID:PMC2970523
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Long, J. Z., Jin, X., Adibekian, A., Li, W. W., Cravatt, B. F. Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases Journal of Medicinal Chemistry 2010 53:1830-1842 DOI:10.1021/jm9016976 PMID:20099888 PMCID:PMC2828288
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Long, J. Z., Li, W. W., Booker, L., Burston, J. J., Kinsey, S. G., Schlosburg, J. E., Pavon, F. J., Serrano, A. M., Selley, D. E., Parsons, L. H., Lichtman, A. H., Cravatt, B. F. Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects Nature Chemical Biology 2009 5:37-44 DOI:10.1038/nchembio.129 PMID:19029917 PMCID:PMC2605181
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Li, W. W., Blankman, J. L., Cravatt, B. F. A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases Journal of the American Chemical Society 2007 129:9594-9595 DOI:10.1021/ja073650c PMID:17629278
- Li, W., Lam, Y. A facile solid-phase synthesis of 1,2,4,5-tetrasubstituted imidazoles using sodium benzenesulfinate as a traceless linker Journal of Combinatorial Chemistry 2005 7:644-647 DOI:10.1021/cc049818x PMID:16153057
- Li, W., Lam, Y. Solid-phase synthesis of 3,4-dihydro-1H-pyrimidine-2-ones using sodium benzenesulfinate as a traceless linker Journal of Combinatorial Chemistry 2005 7:721-725 DOI:10.1021/cc0500295 PMID:16153067
- Li, W., Chen, Y., Lam, Y. Solid-phase synthesis of 3,4-dihydro-1H-pyrimidine-2-ones using sodium benzenesulfinate as a traceless linker Tetrahedron Letters 2004 45:6545-6547 DOI:10.1016/j.tetlet.2004.07.051
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