recent publications
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academic article
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Strauch, E. M., Bernard, S. M., La, D., Bohn, A. J., Lee, P. S., Anderson, C. E., Nieusma, T., Holstein, C. A., Garcia, N. K., Hooper, K. A., Ravichandran, R., Nelson, J. W., et al.
Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site
Nature Biotechnology
2017
35:667-671
DOI:10.1038/nbt.3907
PMID:28604661
PMCID:PMC5512607
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Peng, W., de Vries, R. P., Grant, O. C., Thompson, A. J., McBride, R., Tsogtbaatar, B., Lee, P. S., Razi, N., Wilson, I. A., Woods, R. J., Paulson, J. C.
Recent H3N2 viruses have evolved specificity for extended, branched human-type receptors, conferring potential for increased avidity
Cell Host & Microbe
2017
21:23-34
DOI:10.1016/j.chom.2016.11.004
PMID:28017661
PMCID:PMC5233592
- Lin, S., Yang, X., Jia, S., Weeks, A. M., Hornsby, M., Lee, P. S., Nichiporuk, R. V., Iavarone, A. T., Wells, J. A., Toste, F. D., Chang, C. J. Redox-based reagents for chemoselective methionine bioconjugation Science 2017 355:597-602 PMID:28183972
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Koday, M. T., Nelson, J., Chevalier, A., Koday, M., Kalinoski, H., Stewart, L., Carter, L., Nieusma, T., Lee, P. S., Ward, A. B., Wilson, I. A., Dagley, A., et al.
A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response
PLoS Pathogens
2016
12
DOI:10.1371/journal.ppat.1005409
PMID:26845438
PMCID:PMC4742065
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Chen, W., Dong, J., Plate, L., Mortenson, D. E., Brighty, G. J., Li, S., Liu, Y., Galmozzi, A., Lee, P. S., Hulce, J. J., Cravatt, B. F., Saez, E., et al.
Arylfluorosulfates inactivate intracellular lipid binding protein(s) through chemoselective SuFEx reaction with a binding site Tyr residue
Journal of the American Chemical Society
2016
138:7353-7364
DOI:10.1021/jacs.6b02960
PMID:27191344
PMCID:PMC4909538
- Seaman, J. E., Julien, O., Lee, P. S., Rettenmaier, T. J., Thomsen, N. D., Wells, J. A. Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues Cell Death and Differentiation 2016 23:1717-1726 DOI:10.1038/cdd.2016.62 PMID:27367566 PMCID:PMC5041198
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Impagliazzo, A., Milder, F., Kuipers, H., Wagner, M. V., Zhu, X., Hoffman, R. M. B., van Meersbergen, R., Huizingh, J., Wanningen, P., Verspuij, J., de Man, M., Ding, Z., et al.
A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen
Science
2015
349:1301-1306
DOI:10.1126/science.aac7263
PMID:26303961
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Lee, P. S., Zhu, X., Yu, W., Wilson, I. A.
Design and structure of an engineered disulfide-stabilized influenza virus hemagglutinin trimer
Journal of Virology
2015
89:7417-7420
DOI:10.1128/jvi.00808-15
PMID:25926650
PMCID:PMC4473583
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Lee, P. S., Wilson, I. A.
Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies
Current Topics in Microbiology and Immunology
2015
386:323-341
DOI:10.1007/82_2014_413
PMID:25037260
PMCID:PMC4358778
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Lee, P. S., Arnell, A. J., Wilson, I. A.
Structure of the apo anti-influenza CH65 Fab
Acta Crystallographica Section F-Structural Biology Communications
2015
71:145-148
DOI:10.1107/s2053230x14027599
PMID:25664786
PMCID:PMC4321466
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Friesen, R. H. E., Lee, P. S., Stoop, E. J. M., Hoffman, R. M. B., Ekiert, D. C., Bhabha, G., Yu, W., Juraszek, J., Koudstaal, W., Jongeneelen, M., Korse, H. J. W. M., Ophorst, C., et al.
A common solution to group 2 influenza virus neutralization
Proceedings of the National Academy of Sciences of the United States of America
2014
111:445-450
DOI:10.1073/pnas.1319058110
PMID:24335589
PMCID:PMC3890827
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Tan, G. S., Lee, P. S., Hoffman, R. M. B., Mazel-Sanchez, B., Krammer, F., Leon, P. E., Ward, A. B., Wilson, I. A., Palese, P.
Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin
Journal of Virology
2014
88:13580-13592
DOI:10.1128/jvi.02289-14
PMID:25210195
PMCID:PMC4248980
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Lee, P. S., Ohshima, N., Stanfield, R. L., Yu, W., Iba, Y., Okuno, Y., Kurosawa, Y., Wilson, I. A.
Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus
Nature Communications
2014
5:3614
DOI:10.1038/ncomms4614
PMID:24717798
PMCID:PMC4358779
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Sok, D., van Gils, M. J., Pauthner, M., Julien, J. P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., et al.
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex
Proceedings of the National Academy of Sciences of the United States of America
2014
111:17624-17629
DOI:10.1073/pnas.1415789111
PMID:25422458
PMCID:PMC4267403
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Blattner, C., Lee, J. H., Sliepen, K., Derking, R., Falkowska, E., de la Pena, A. T., Cupo, A., Julien, J. P., van Gils, M., Lee, P. S., Peng, W., Paulson, J. C., et al.
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers
Immunity
2014
40:669-680
DOI:10.1016/j.immuni.2014.04.008
PMID:24768348
PMCID:PMC4057017
- Batchelor, J. D., Lee, P. S., Wang, A. C., Doucleff, M., Wemmer, D. E. Structural mechanism of GAF-regulated sigma(54) activators from Aquifex aeolicus Journal of Molecular Biology 2013 425:156-170 DOI:10.1016/j.jmb.2012.10.017 PMID:23123379 PMCID:PMC3544215
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Hong, M., Lee, P. S., Hoffman, R. M. B., Zhu, X., Krause, J. C., Laursen, N. S., Yoon, S. I., Song, L., Tussey, L., Crowe, J. E., Ward, A. B., Wilson, I. A.
Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site
Journal of Virology
2013
87:12471-12480
DOI:10.1128/jvi.01388-13
PMID:24027321
PMCID:PMC3807900
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Lee, P. S., Yoshida, R., Ekiert, D. C., Sakai, N., Suzuki, Y., Takada, A., Wilson, I. A.
Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity
Proceedings of the National Academy of Sciences of the United States of America
2012
109:17040-17045
DOI:10.1073/pnas.1212371109
PMID:23027945
PMCID:PMC3479480
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Julien, J. P., Lee, P. S., Wilson, I. A.
Structural insights into key sites of vulnerability on hiv-1 env and influenza ha
Immunological Reviews
2012
250:180-198
DOI:10.1111/imr.12005
PMID:23046130
PMCID:PMC3479221
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Lee, P. S., Zhang, H. M., Marshall, A. G., Yang, X. L., Schimmel, P.
Uncovering of a short internal peptide activates a tRNA synthetase procytokine
Journal of Biological Chemistry
2012
287:20504-20508
DOI:10.1074/jbc.C112.369439
PMID:22549774
PMCID:PMC3370235
- Doucleff, M., Pelton, J. G., Lee, P. S., Nixon, B. T., Wemmer, D. E. Structural basis of DNA recognition by the alternative sigma-factor, sigma54 Journal of Molecular Biology 2007 369:1070-1078 DOI:10.1016/j.jmb.2007.04.019 PMID:17481658 PMCID:PMC2680387
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