recent publications
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academic article
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Strauch, E. M., Bernard, S. M., La, D., Bohn, A. J., Lee, P. S., Anderson, C. E., Nieusma, T., Holstein, C. A., Garcia, N. K., Hooper, K. A., Ravichandran, R., Nelson, J. W., et al. Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site Nature Biotechnology 2017 35:667-671 DOI:10.1038/nbt.3907 PMID:28604661 PMCID:PMC5512607
- Lin, S., Yang, X., Jia, S., Weeks, A. M., Hornsby, M., Lee, P. S., Nichiporuk, R. V., Iavarone, A. T., Wells, J. A., Toste, F. D., Chang, C. J. Redox-based reagents for chemoselective methionine bioconjugation Science 2017 355:597-602 PMID:28183972
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Peng, W., de Vries, R. P., Grant, O. C., Thompson, A. J., McBride, R., Tsogtbaatar, B., Lee, P. S., Razi, N., Wilson, I. A., Woods, R. J., Paulson, J. C. Recent H3N2 viruses have evolved specificity for extended, branched human-type receptors, conferring potential for increased avidity Cell Host & Microbe 2017 21:23-34 DOI:10.1016/j.chom.2016.11.004 PMID:28017661 PMCID:PMC5233592
- Seaman, J. E., Julien, O., Lee, P. S., Rettenmaier, T. J., Thomsen, N. D., Wells, J. A. Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues Cell Death and Differentiation 2016 23:1717-1726 DOI:10.1038/cdd.2016.62 PMID:27367566 PMCID:PMC5041198
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Chen, W., Dong, J., Plate, L., Mortenson, D. E., Brighty, G. J., Li, S., Liu, Y., Galmozzi, A., Lee, P. S., Hulce, J. J., Cravatt, B. F., Saez, E., et al. Arylfluorosulfates inactivate intracellular lipid binding protein(s) through chemoselective SuFEx reaction with a binding site Tyr residue Journal of the American Chemical Society 2016 138:7353-7364 DOI:10.1021/jacs.6b02960 PMID:27191344 PMCID:PMC4909538
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Koday, M. T., Nelson, J., Chevalier, A., Koday, M., Kalinoski, H., Stewart, L., Carter, L., Nieusma, T., Lee, P. S., Ward, A. B., Wilson, I. A., Dagley, A., et al. A Computationally Designed Hemagglutinin Stem-Binding Protein Provides In Vivo Protection from Influenza Independent of a Host Immune Response PLoS Pathogens 2016 12 DOI:10.1371/journal.ppat.1005409 PMID:26845438 PMCID:PMC4742065
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Impagliazzo, A., Milder, F., Kuipers, H., Wagner, M. V., Zhu, X., Hoffman, R. M. B., van Meersbergen, R., Huizingh, J., Wanningen, P., Verspuij, J., de Man, M., Ding, Z., et al. A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen Science 2015 349:1301-1306 DOI:10.1126/science.aac7263 PMID:26303961
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Lee, P. S., Zhu, X., Yu, W., Wilson, I. A. Design and structure of an engineered disulfide-stabilized influenza virus hemagglutinin trimer Journal of Virology 2015 89:7417-7420 DOI:10.1128/jvi.00808-15 PMID:25926650 PMCID:PMC4473583
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Lee, P. S., Arnell, A. J., Wilson, I. A. Structure of the apo anti-influenza CH65 Fab Acta Crystallographica Section F-Structural Biology Communications 2015 71:145-148 DOI:10.1107/s2053230x14027599 PMID:25664786 PMCID:PMC4321466
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Lee, P. S., Wilson, I. A. Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies Current Topics in Microbiology and Immunology 2015 386:323-341 DOI:10.1007/82_2014_413 PMID:25037260 PMCID:PMC4358778
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Sok, D., van Gils, M. J., Pauthner, M., Julien, J. P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex Proceedings of the National Academy of Sciences of the United States of America 2014 111:17624-17629 DOI:10.1073/pnas.1415789111 PMID:25422458 PMCID:PMC4267403
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Tan, G. S., Lee, P. S., Hoffman, R. M. B., Mazel-Sanchez, B., Krammer, F., Leon, P. E., Ward, A. B., Wilson, I. A., Palese, P. Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin Journal of Virology 2014 88:13580-13592 DOI:10.1128/jvi.02289-14 PMID:25210195 PMCID:PMC4248980
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Blattner, C., Lee, J. H., Sliepen, K., Derking, R., Falkowska, E., de la Pena, A. T., Cupo, A., Julien, J. P., van Gils, M., Lee, P. S., Peng, W., Paulson, J. C., et al. Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers Immunity 2014 40:669-680 DOI:10.1016/j.immuni.2014.04.008 PMID:24768348 PMCID:PMC4057017
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Lee, P. S., Ohshima, N., Stanfield, R. L., Yu, W., Iba, Y., Okuno, Y., Kurosawa, Y., Wilson, I. A. Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus Nature Communications 2014 5:3614 DOI:10.1038/ncomms4614 PMID:24717798 PMCID:PMC4358779
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Friesen, R. H. E., Lee, P. S., Stoop, E. J. M., Hoffman, R. M. B., Ekiert, D. C., Bhabha, G., Yu, W., Juraszek, J., Koudstaal, W., Jongeneelen, M., Korse, H. J. W. M., Ophorst, C., et al. A common solution to group 2 influenza virus neutralization Proceedings of the National Academy of Sciences of the United States of America 2014 111:445-450 DOI:10.1073/pnas.1319058110 PMID:24335589 PMCID:PMC3890827
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Hong, M., Lee, P. S., Hoffman, R. M. B., Zhu, X., Krause, J. C., Laursen, N. S., Yoon, S. I., Song, L., Tussey, L., Crowe, J. E., Ward, A. B., Wilson, I. A. Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site Journal of Virology 2013 87:12471-12480 DOI:10.1128/jvi.01388-13 PMID:24027321 PMCID:PMC3807900
- Batchelor, J. D., Lee, P. S., Wang, A. C., Doucleff, M., Wemmer, D. E. Structural mechanism of GAF-regulated sigma(54) activators from Aquifex aeolicus Journal of Molecular Biology 2013 425:156-170 DOI:10.1016/j.jmb.2012.10.017 PMID:23123379 PMCID:PMC3544215
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Julien, J. P., Lee, P. S., Wilson, I. A. Structural insights into key sites of vulnerability on hiv-1 env and influenza ha Immunological Reviews 2012 250:180-198 DOI:10.1111/imr.12005 PMID:23046130 PMCID:PMC3479221
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Lee, P. S., Yoshida, R., Ekiert, D. C., Sakai, N., Suzuki, Y., Takada, A., Wilson, I. A. Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity Proceedings of the National Academy of Sciences of the United States of America 2012 109:17040-17045 DOI:10.1073/pnas.1212371109 PMID:23027945 PMCID:PMC3479480
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Lee, P. S., Zhang, H. M., Marshall, A. G., Yang, X. L., Schimmel, P. Uncovering of a short internal peptide activates a tRNA synthetase procytokine Journal of Biological Chemistry 2012 287:20504-20508 DOI:10.1074/jbc.C112.369439 PMID:22549774 PMCID:PMC3370235
- Doucleff, M., Pelton, J. G., Lee, P. S., Nixon, B. T., Wemmer, D. E. Structural basis of DNA recognition by the alternative sigma-factor, sigma54 Journal of Molecular Biology 2007 369:1070-1078 DOI:10.1016/j.jmb.2007.04.019 PMID:17481658 PMCID:PMC2680387
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