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Lee, Jeong Hyun
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Lee, Jeong Hyun

Graduate Student
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Positions

  • 2017 - Postdoctoral Research Associate, La Jolla Institute for Allergy and Immunology

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  • Doctoral Dissertation
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Publications

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  • academic article

    • Pauthner, M. G., Nkolola, J. P., Havenar-Daughton, C., Murrell, B., Reiss, S. M., Bastidas, R., Prevost, J., Nedellec, R., von Bredow, B., Abbink, P., Cottrell, C. A., Kulp, D. W., et al. Vaccine-induced protection from homologous tier 2 SHIV challenge in nonhuman primates depends on serum-neutralizing antibody titers Immunity  2019 50:241-252  DOI:10.1016/j.immuni.2018.11.011  PMID:30552025  PMCID:PMC6335502
    • Abbott, R. K., Lee, J. H., Menis, S., Skog, P., Rossi, M., Ota, T., Kulp, D. W., Bhullar, D., Kalyuzhniy, O., Havenar-Daughton, C., Schief, W. R., Nemazee, D., et al. Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens Immunity  2018 48:133-146  DOI:10.1016/j.immuni.2017.11.023  PMID:29287996  PMCID:PMC5773359
    • degree-related publication Lee, J. H., Andrabi, R., Su, C. Y., Yasmeen, A., Julien, J. P., Kong, L., Wu, N. C., McBride, R., Sok, D., Pauthner, M., Cottrell, C. A., Nieusma, T., et al. A broadly neutralizing antibody targets the dynamic HIV envelope trimer apex via a long, rigidified, and anionic β-hairpin structure Immunity  2017 46:690-702  DOI:10.1016/j.immuni.2017.03.017  PMID:28423342  PMCID:PMC5400778
    • Havenar-Daughton, C., Lee, J. H., Crotty, S. Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem Immunological Reviews  2017 275:49-61  DOI:10.1111/imr.12512  PMID:28133798
    • degree-related publication Sok, D., Pauthner, M., Briney, B., Lee, J. H., Saye-Francisco, K. L., Hsueh, J., Ramos, A., Le, K. M., Jones, M., Jardine, J. G., Bastidas, R., Sarkar, A., et al. A prominent site of antibody vulnerability on HIV envelope incorporates a motif associated with CCR5 binding and its camouflaging glycans Immunity  2016 45:31-45  DOI:10.1016/j.immuni.2016.06.026  PMID:27438765  PMCID:PMC4990068
    • degree-related publication Behrens, A. J., Vasiljevic, S., Pritchard, L. K., Harvey, D. J., Andev, R. S., Krumm, S. A., Struwe, W. B., Cupo, A., Kumar, A., Zitzmann, N., Seabright, G. E., Kramer, H. B., et al. Composition and antigenic effects of individual glycan sites of a trimeric HIV-1 envelope glycoprotein Cell Reports  2016 14:2695-2706  DOI:10.1016/j.celrep.2016.02.058  PMID:26972002  PMCID:PMC4805854
    • degree-related publication Lee, J. H., Ozorowski, G., Ward, A. B. Cryo-EM structure of a native, fully glycosylated, cleaved HIV-1 envelope trimer Science  2016 351:1043-1048  DOI:10.1126/science.aad2450  PMID:26941313  PMCID:PMC5001164
    • degree-related publication Sanders, R. W., van Gils, M. J., Derking, R., Sok, D., Ketas, T. J., Burger, J. A., Ozorowski, G., Cupo, A., Simonich, C., Goo, L., Arendt, H., Kim, H. J., et al. HIV-1 neutralizing antibodies induced by native-like envelope trimers Science  2015 349  DOI:10.1126/science.aac4223  PMID:26089353  PMCID:PMC4498988
    • degree-related publication Garces, F., Lee, J. H., de Val, N., Torrents de la Peña, A., Kong, L., Puchades, C., Hua, Y., Stanfield, R. L., Burton, D. R., Moore, J. P., Sanders, R. W., Ward, A. B., et al. Affinity maturation of a potent family of HIV antibodies is primarily focused on accommodating or avoiding glycans Immunity  2015 43:1053-1063  DOI:10.1016/j.immuni.2015.11.007  PMID:26682982  PMCID:PMC4692269
    • degree-related publication Lee, J. H., Leaman, D. P., Kim, A. S., Torrents de la Peña, A., Sliepen, K., Yasmeen, A., Derking, R., Ramos, A., de Taeye, S. W., Ozorowski, G., Klein, F., Burton, D. R., et al. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike Nature Communications  2015 6:8167  DOI:10.1038/ncomms9167  PMID:26404402  PMCID:PMC4586043
    • degree-related publication Derking, R., Ozorowski, G., Sliepen, K., Yasmeen, A., Cupo, A., Torres, J. L., Julien, J. P., Lee, J. H., van Montfort, T., de Taeye, S. W., Connors, M., Burton, D. R., et al. Comprehensive antigenic map of a cleaved soluble HIV-1 envelope trimer PLoS Pathogens  2015 11:e1004767  DOI:10.1371/journal.ppat.1004767  PMID:25807248  PMCID:PMC4373910
    • degree-related publication Julien, J. P., Lee, J. H., Ozorowski, G., Hua, Y., Torrents de la Peña, A., de Taeye, S. W., Nieusma, T., Cupo, A., Yasmeen, A., Golabek, M., Pugach, P., Klasse, P. J., et al. Design and structure of two HIV-1 clade C SOSIP.664 trimers that increase the arsenal of native-like Env immunogens Proceedings of the National Academy of Sciences of the United States of America  2015 112:11947-11952  DOI:10.1073/pnas.1507793112  PMID:26372963  PMCID:PMC4586835
    • degree-related publication Leaman, D. P., Lee, J. H., Ward, A. B., Zwick, M. B. Immunogenic display of purified chemically cross-linked HIV-1 spikes Journal of Virology  2015 89:6725-6745  DOI:10.1128/jvi.03738-14  PMID:25878116  PMCID:PMC4468504
    • degree-related publication Lee, J. H., de Val, N., Lyumkis, D., Ward, A. B. Model building and refinement of a natively glycosylated HIV-1 Env protein by high-resolution cryoelectron microscopy Structure  2015 23:1943-1951  DOI:10.1016/j.str.2015.07.020  PMID:26388028  PMCID:PMC4618500
    • degree-related publication Scharf, L., Scheid, J. F., Lee, J. H., West Jr., A. P., Chen, C., Gao, H., Gnanapragasam, P. N. P., Mares, R., Seaman, M. S., Ward, A. B., Nussenzweig, M. C., Bjorkman, P. J. Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike Cell Reports  2014 7:785-795  DOI:10.1016/j.celrep.2014.04.001  PMID:24767986  PMCID:PMC4109818
    • degree-related publication Huang, J., Kang, B. H., Pancera, M., Lee, J. H., Tong, T., Feng, Y., Imamichi, H., Georgiev, I. S., Chuang, G. Y., Druz, A., Doria-Rose, N. A., Laub, L., et al. Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface Nature  2014 515:138-142  DOI:10.1038/nature13601  PMID:25186731  PMCID:PMC4224615
    • degree-related publication Falkowska, E., Le, K. M., Ramos, A., Doores, K. J., Lee, J. H., Blattner, C., Ramirez, A., Derking, R., van Gils, M. J., Liang, C. H., McBride, R., von Bredow, B., et al. Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers Immunity  2014 40:657-668  DOI:10.1016/j.immuni.2014.04.009  PMID:24768347  PMCID:PMC4070425
    • degree-related publication Sok, D., van Gils, M. J., Pauthner, M., Julien, J. P., Saye-Francisco, K. L., Hsueh, J., Briney, B., Lee, J. H., Le, K. M., Lee, P. S., Hua, Y., Seaman, M. S., et al. Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex Proceedings of the National Academy of Sciences of the United States of America  2014 111:17624-17629  DOI:10.1073/pnas.1415789111  PMID:25422458  PMCID:PMC4267403
    • degree-related publication Blattner, C., Lee, J. H., Sliepen, K., Derking, R., Falkowska, E., de la Pena, A. T., Cupo, A., Julien, J. P., van Gils, M., Lee, P. S., Peng, W., Paulson, J. C., et al. Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers Immunity  2014 40:669-680  DOI:10.1016/j.immuni.2014.04.008  PMID:24768348  PMCID:PMC4057017
    • degree-related publication Julien, J. P., Lee, J. H., Cupo, A., Murin, C. D., Derking, R., Hoffenberg, S., Caulfield, M. J., King, C. R., Marozsan, A. J., Klasse, P. J., Sanders, R. W., Moore, J. P., et al. Asymmetric recognition of the HIV-1 trimer by broadly neutralizing antibody PG9 Proceedings of the National Academy of Sciences of the United States of America  2013 110:213-218  DOI:10.1073/pnas.1217537110  PMID:23426631  PMCID:PMC3600498
    • degree-related publication Julien, J. P., Sok, D., Khayat, R., Lee, J. H., Doores, K. J., Walker, L. M., Ramos, A., Diwanji, D. C., Pejchal, R., Cupo, A., Katpally, U., Depetris, R. S., et al. Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans PLoS Pathogens  2013 9:e1003342  DOI:10.1371/journal.ppat.1003342  PMID:23658524  PMCID:PMC3642082
    • degree-related publication Ringe, R. P., Sanders, R. W., Yasmeen, A., Kim, H. J., Lee, J. H., Cupo, A., Korzun, J., Derking, R., van Montfort, T., Julien, J. P., Wilson, I. A., Klasse, P. J., et al. Cleavage strongly influences whether soluble HIV-1 envelope glycoprotein trimers adopt a native-like conformation Proceedings of the National Academy of Sciences of the United States of America  2013 110:18256-18261  DOI:10.1073/pnas.1314351110  PMID:24145402  PMCID:PMC3831437
    • degree-related publication Thornburg, N. J., Nannemann, D. P., Blum, D. L., Belser, J. A., Tumpey, T. M., Deshpande, S., Fritz, G. A., Sapparapu, G., Krause, J. C., Lee, J. H., Ward, A. B., Lee, D. E., et al. Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses Journal of Clinical Investigation  2013 123:4405-4409  DOI:10.1172/jci69377  PMID:23999429  PMCID:PMC3784541
    • degree-related publication Klasse, P. J., Depetris, R. S., Pejchal, R., Julien, J. P., Khayat, R., Lee, J. H., Marozsan, A. J., Cupo, A., Cocco, N., Korzun, J., Yasmeen, A., Ward, A. B., et al. Influences on Trimerization and Aggregation of Soluble, Cleaved HIV-1 SOSIP Envelope Glycoprotein Journal of Virology  2013 87:9873-9885  DOI:10.1128/jvi.01226-13  PMID:23824824  PMCID:PMC3754145
    • degree-related publication Khayat, R., Lee, J. H., Julien, J. P., Cupo, A., Klasse, P. J., Sanders, R. W., Moore, J. P., Wilson, I. A., Ward, A. B. Structural characterization of cleaved, soluble HIV-1 envelope glycoprotein trimers Journal of Virology  2013 87:9865-9872  DOI:10.1128/jvi.01222-13  PMID:23824817  PMCID:PMC3754114
    • degree-related publication Kong, L., Lee, J. H., Doores, K. J., Murin, C. D., Julien, J. P., McBride, R., Liu, Y., Marozsan, A., Cupo, A., Klasse, P. J., Hoffenberg, S., Caulfield, M., et al. Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120 Nature Structural & Molecular Biology  2013 20:796-803  DOI:10.1038/nsmb.2594  PMID:23708606  PMCID:PMC3823233
    • degree-related publication Ekiert, D. C., Kashyap, A. K., Steel, J., Rubrum, A., Bhabha, G., Khayat, R., Lee, J. H., Dillon, M. A., O'Neil, R. E., Faynboym, A. M., Horowitz, M., Horowitz, L., et al. Cross-neutralization of influenza a viruses mediated by a single antibody loop Nature  2012 489:526-32  DOI:10.1038/nature11414  PMID:22982990  PMCID:PMC3538848
    • degree-related publication Dreyfus, C., Laursen, N. S., Kwaks, T., Zuijdgeest, D., Khayat, R., Ekiert, D. C., Lee, J. H., Metlagel, Z., Bujny, M. V., Jongeneelen, M., van der Vlugt, R., Lamrani, M., et al. Highly conserved protective epitopes on influenza B viruses Science  2012 337:1343-1348  DOI:10.1126/science.1222908  PMID:22878502  PMCID:PMC3538841
    • degree-related publication Depetris, R. S., Julien, J. P., Khayat, R., Lee, J. H., Pejchal, R., Katpally, U., Cocco, N., Kachare, M., Massi, E., David, K. B., Cupo, A., Marozsan, A. J., et al. Partial enzymatic deglycosylation preserves the structure of cleaved recombinant HIV-1 envelope glycoprotein trimers Journal of Biological Chemistry  2012 287:24239-24254  DOI:10.1074/jbc.M112.371898  PMID:22645128  PMCID:PMC3397850
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Background

education and training

  • Ph.D. in Chemical Biology, Scripps Research 2011 - 2016
  • B.A. in Chemistry, University of Virginia 2006 - 2010

advisee of

  • graduate advising relationship

    • Ward, Andrew, Ph.D.  candidacy, 2012 - 2016
    • Wilson, Ian, Ph.D.  candidacy, 2012 - 2016
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Contact

full name

  • Jeong Hyun Lee

geographic location

  • Scripps California 

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