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Leaman, Daniel
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Leaman, Daniel

Graduate Student
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Positions

  • 2019 - Staff Scientist, Scripps Research
  • 2012 - 2018 Postdoctoral Research Associate, Scripps Research
  • 2001 - 2006 Research Assistant, The Rockefeller University
  • 2000 - 2001 Research Assistant, University of Pittsburgh

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  • Doctoral Dissertation
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Publications

recent publications
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  • academic article

    • Rujas, E., Leaman, D. P., Insausti, S., Ortigosa-Pascual, L., Zhang, L., Zwick, M. B., Nieva, J. L. Functional optimization of broadly neutralizing HIV-1 antibody 10E8 by promotion of membrane interactions Journal of Virology  2018 92:e02249-17  DOI:10.1128/jvi.02249-17  PMID:29386285  PMCID:PMC5874428
    • Stano, A., Leaman, D. P., Kim, A. S., Zhang, L., Autin, L., Ingale, J., Gift, S. K., Truong, J., Wyatt, R. T., Olson, A. J., Zwick, M. B. Dense array of spikes on HIV-1 virion particles Journal of Virology  2017 91:e00415-17  DOI:10.1128/jvi.00415-17  PMID:28446665  PMCID:PMC5487557
    • Gift, S. K., Leaman, D. P., Zhang, L., Kim, A. S., Zwick, M. B. Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex Journal of Virology  2017 91:e01216-17  DOI:10.1128/jvi.01216-17  PMID:28978711  PMCID:PMC5709597
    • Lee, J. H., Leaman, D. P., Kim, A. S., Torrents de la Peña, A., Sliepen, K., Yasmeen, A., Derking, R., Ramos, A., de Taeye, S. W., Ozorowski, G., Klein, F., Burton, D. R., et al. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike Nature Communications  2015 6:8167  DOI:10.1038/ncomms9167  PMID:26404402  PMCID:PMC4586043
    • Leaman, D. P., Lee, J. H., Ward, A. B., Zwick, M. B. Immunogenic display of purified chemically cross-linked HIV-1 spikes Journal of Virology  2015 89:6725-6745  DOI:10.1128/jvi.03738-14  PMID:25878116  PMCID:PMC4468504
    • Kim, A. S., Leaman, D. P., Zwick, M. B. Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization PLoS Pathogens  2014 10:e1004271  DOI:10.1371/journal.ppat.1004271  PMID:25058619  PMCID:PMC4110039
    • Leaman, D. P., Zwick, M. B. Increased functional stability and homogeneity of viral envelope spikes through directed evolution PLoS Pathogens  2013 9:e1003184  DOI:10.1371/journal.ppat.1003184  PMID:23468626  PMCID:PMC3585149
    • Narayan, K. M., Agrawal, N., Du, S. X., Muranaka, J. E., Bauer, K., Leaman, D. P., Phung, P., Limoli, K., Chen, H. L., Boenig, R. I., Wrin, T., Zwick, M. B., et al. Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate PLoS One  2013 8:e52732  DOI:10.1371/journal.pone.0052732  PMID:23326351  PMCID:PMC3541383
    • degree-related publication Agrawal, N., Leaman, D. P., Rowcliffe, E., Kinkead, H., Nohria, R., Akagi, J., Bauer, K., Du, S. X., Whalen, R. G., Burton, D. R., Zwick, M. B. Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1) PLoS One  2011 6:e21339  DOI:10.1371/journal.pone.0021339  PMID:21738637  PMCID:PMC3124497
    • degree-related publication Gach, J. S., Leaman, D. P., Zwick, M. B. Targeting HIV-1 gp41 in close proximity to the membrane using antibody and other molecules Current Topics in Medicinal Chemistry  2011 11:2997-3021  DOI:10.2174/156802611798808505  PMID:22044228
    • degree-related publication Murray, E. J., Leaman, D. P., Pawa, N., Perkins, H., Pickford, C., Perros, M., Zwick, M. B., Butler, S. L. A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41 Journal of Virology  2010 84:7288-7299  DOI:10.1128/jvi.00535-10  PMID:20427524  PMCID:PMC2898251
    • degree-related publication Scherer, E. M., Leaman, D. P., Zwick, M. B., McMichael, A. J., Burton, D. R. Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions Proceedings of the National Academy of Sciences of the United States of America  2010 107:1529-1534  DOI:10.1073/pnas.0909680107  PMID:20080706  PMCID:PMC2824387
    • degree-related publication Leaman, D. P., Kinkead, H., Zwick, M. B. In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1 Journal of Virology  2010 84:3382-3395  DOI:10.1128/jvi.02363-09  PMID:20089658  PMCID:PMC2838137
    • Kurant, E., Axelrod, S., Leaman, D., Gaul, U. Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons Cell  2008 133:498-509  DOI:10.1016/j.cell.2008.02.052  PMID:18455990  PMCID:PMC2730188
    • degree-related publication Nelson, J. D., Kinkead, H., Brunel, F. M., Leaman, D., Jensen, R., Louis, J. M., Maruyama, T., Bewley, C. A., Bowdish, K., Clore, G. M., Dawson, P. E., Frederickson, S., et al. Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics Virology  2008 377:170-183  DOI:10.1016/j.virol.2008.04.005  PMID:18499210  PMCID:PMC2493441
    • degree-related publication Reynolds, M. R., Weiler, A. M., Weisgrau, K. L., Piaskowski, S. M., Furlott, J. R., Weinfurter, J. T., Kaizu, M., Soma, T., Leon, E. J., MacNair, C., Leaman, D. P., Zwick, M. B., et al. Macaques vaccinated with live-attenuated SIV control replication of heterologous virus Journal of Experimental Medicine  2008 205:2537-2550  DOI:10.1084/jem.20081524  PMID:18838548  PMCID:PMC2571929
    • Leaman, D., Chen, P. Y., Fak, J., Yalcin, A., Pearce, M., Unnerstall, U., Marks, D. S., Sander, C., Tuschl, T., Gaul, U. Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development Cell  2005 121:1097-1108  DOI:10.1016/j.cell.2005.04.016  PMID:15989958
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Background

education and training

  • Ph.D. in Chemical Biology, Scripps Research 2006 - 2012
  • B.S. in Biochemistry and Molecular Biology, University of Pittsburgh 1996 - 2000

advisee of

  • graduate advising relationship

    • Zwick, Michael, Ph.D.  candidacy, 2007 - 2012
  • postdoc or fellow advising relationship

    • Zwick, Michael, Ph.D.  candidacy, 2012 -
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Contact

full name

  • Daniel P Leaman

geographic location

  • Scripps California 

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