recent publications
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academic article
- Rujas, E., Leaman, D. P., Insausti, S., Ortigosa-Pascual, L., Zhang, L., Zwick, M. B., Nieva, J. L. Functional optimization of broadly neutralizing HIV-1 antibody 10E8 by promotion of membrane interactions Journal of Virology 2018 92:e02249-17 DOI:10.1128/jvi.02249-17 PMID:29386285 PMCID:PMC5874428
- Stano, A., Leaman, D. P., Kim, A. S., Zhang, L., Autin, L., Ingale, J., Gift, S. K., Truong, J., Wyatt, R. T., Olson, A. J., Zwick, M. B. Dense array of spikes on HIV-1 virion particles Journal of Virology 2017 91:e00415-17 DOI:10.1128/jvi.00415-17 PMID:28446665 PMCID:PMC5487557
- Gift, S. K., Leaman, D. P., Zhang, L., Kim, A. S., Zwick, M. B. Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex Journal of Virology 2017 91:e01216-17 DOI:10.1128/jvi.01216-17 PMID:28978711 PMCID:PMC5709597
- Lee, J. H., Leaman, D. P., Kim, A. S., Torrents de la Peña, A., Sliepen, K., Yasmeen, A., Derking, R., Ramos, A., de Taeye, S. W., Ozorowski, G., Klein, F., Burton, D. R., et al. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike Nature Communications 2015 6:8167 DOI:10.1038/ncomms9167 PMID:26404402 PMCID:PMC4586043
- Leaman, D. P., Lee, J. H., Ward, A. B., Zwick, M. B. Immunogenic display of purified chemically cross-linked HIV-1 spikes Journal of Virology 2015 89:6725-6745 DOI:10.1128/jvi.03738-14 PMID:25878116 PMCID:PMC4468504
- Kim, A. S., Leaman, D. P., Zwick, M. B. Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization PLoS Pathogens 2014 10:e1004271 DOI:10.1371/journal.ppat.1004271 PMID:25058619 PMCID:PMC4110039
- Leaman, D. P., Zwick, M. B. Increased functional stability and homogeneity of viral envelope spikes through directed evolution PLoS Pathogens 2013 9:e1003184 DOI:10.1371/journal.ppat.1003184 PMID:23468626 PMCID:PMC3585149
- Narayan, K. M., Agrawal, N., Du, S. X., Muranaka, J. E., Bauer, K., Leaman, D. P., Phung, P., Limoli, K., Chen, H. L., Boenig, R. I., Wrin, T., Zwick, M. B., et al. Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate PLoS One 2013 8:e52732 DOI:10.1371/journal.pone.0052732 PMID:23326351 PMCID:PMC3541383
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Agrawal, N., Leaman, D. P., Rowcliffe, E., Kinkead, H., Nohria, R., Akagi, J., Bauer, K., Du, S. X., Whalen, R. G., Burton, D. R., Zwick, M. B. Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1) PLoS One 2011 6:e21339 DOI:10.1371/journal.pone.0021339 PMID:21738637 PMCID:PMC3124497
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Gach, J. S., Leaman, D. P., Zwick, M. B. Targeting HIV-1 gp41 in close proximity to the membrane using antibody and other molecules Current Topics in Medicinal Chemistry 2011 11:2997-3021 DOI:10.2174/156802611798808505 PMID:22044228
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Murray, E. J., Leaman, D. P., Pawa, N., Perkins, H., Pickford, C., Perros, M., Zwick, M. B., Butler, S. L. A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41 Journal of Virology 2010 84:7288-7299 DOI:10.1128/jvi.00535-10 PMID:20427524 PMCID:PMC2898251
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Scherer, E. M., Leaman, D. P., Zwick, M. B., McMichael, A. J., Burton, D. R. Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions Proceedings of the National Academy of Sciences of the United States of America 2010 107:1529-1534 DOI:10.1073/pnas.0909680107 PMID:20080706 PMCID:PMC2824387
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Leaman, D. P., Kinkead, H., Zwick, M. B. In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1 Journal of Virology 2010 84:3382-3395 DOI:10.1128/jvi.02363-09 PMID:20089658 PMCID:PMC2838137
- Kurant, E., Axelrod, S., Leaman, D., Gaul, U. Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons Cell 2008 133:498-509 DOI:10.1016/j.cell.2008.02.052 PMID:18455990 PMCID:PMC2730188
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Nelson, J. D., Kinkead, H., Brunel, F. M., Leaman, D., Jensen, R., Louis, J. M., Maruyama, T., Bewley, C. A., Bowdish, K., Clore, G. M., Dawson, P. E., Frederickson, S., et al. Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics Virology 2008 377:170-183 DOI:10.1016/j.virol.2008.04.005 PMID:18499210 PMCID:PMC2493441
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Reynolds, M. R., Weiler, A. M., Weisgrau, K. L., Piaskowski, S. M., Furlott, J. R., Weinfurter, J. T., Kaizu, M., Soma, T., Leon, E. J., MacNair, C., Leaman, D. P., Zwick, M. B., et al. Macaques vaccinated with live-attenuated SIV control replication of heterologous virus Journal of Experimental Medicine 2008 205:2537-2550 DOI:10.1084/jem.20081524 PMID:18838548 PMCID:PMC2571929
- Leaman, D., Chen, P. Y., Fak, J., Yalcin, A., Pearce, M., Unnerstall, U., Marks, D. S., Sander, C., Tuschl, T., Gaul, U. Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development Cell 2005 121:1097-1108 DOI:10.1016/j.cell.2005.04.016 PMID:15989958