recent publications
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academic article
- Rujas, E., Insausti, S., Leaman, D. P., Carravilla, P., Gonzalez-Resines, S., Monceaux, V., Sanchez-Eugenia, R., Garcia-Porras, M., Iloro, I., Zhang, L., Elortza, F., Julien, J. P., et al. Affinity for the Interface Underpins Potency of Antibodies Operating In Membrane Environments Cell Reports 2020 32 DOI:10.1016/j.celrep.2020.108037 PMID:32814041
- Rujas, E., Leaman, D. P., Insausti, S., Ortigosa-Pascual, L., Zhang, L., Zwick, M. B., Nieva, J. L. Functional optimization of broadly neutralizing HIV-1 antibody 10E8 by promotion of membrane interactions Journal of Virology 2018 92:e02249-17 DOI:10.1128/jvi.02249-17 PMID:29386285 PMCID:PMC5874428
- Gift, S. K., Leaman, D. P., Zhang, L., Kim, A. S., Zwick, M. B. Functional stability of HIV-1 envelope trimer affects accessibility to broadly neutralizing antibodies at its apex Journal of Virology 2017 91:e01216-17 DOI:10.1128/jvi.01216-17 PMID:28978711 PMCID:PMC5709597
- Stano, A., Leaman, D. P., Kim, A. S., Zhang, L., Autin, L., Ingale, J., Gift, S. K., Truong, J., Wyatt, R. T., Olson, A. J., Zwick, M. B. Dense array of spikes on HIV-1 virion particles Journal of Virology 2017 91:e00415-17 DOI:10.1128/jvi.00415-17 PMID:28446665 PMCID:PMC5487557
- Lee, J. H., Leaman, D. P., Kim, A. S., Torrents de la Peña, A., Sliepen, K., Yasmeen, A., Derking, R., Ramos, A., de Taeye, S. W., Ozorowski, G., Klein, F., Burton, D. R., et al. Antibodies to a conformational epitope on gp41 neutralize HIV-1 by destabilizing the Env spike Nature Communications 2015 6:8167 DOI:10.1038/ncomms9167 PMID:26404402 PMCID:PMC4586043
- Leaman, D. P., Lee, J. H., Ward, A. B., Zwick, M. B. Immunogenic display of purified chemically cross-linked HIV-1 spikes Journal of Virology 2015 89:6725-6745 DOI:10.1128/jvi.03738-14 PMID:25878116 PMCID:PMC4468504
- Kim, A. S., Leaman, D. P., Zwick, M. B. Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization PLoS Pathogens 2014 10:e1004271 DOI:10.1371/journal.ppat.1004271 PMID:25058619 PMCID:PMC4110039
- Narayan, K. M., Agrawal, N., Du, S. X., Muranaka, J. E., Bauer, K., Leaman, D. P., Phung, P., Limoli, K., Chen, H. L., Boenig, R. I., Wrin, T., Zwick, M. B., et al. Prime-boost immunization of rabbits with HIV-1 gp120 elicits potent neutralization activity against a primary viral isolate PLoS One 2013 8:e52732 DOI:10.1371/journal.pone.0052732 PMID:23326351 PMCID:PMC3541383
- Leaman, D. P., Zwick, M. B. Increased functional stability and homogeneity of viral envelope spikes through directed evolution PLoS Pathogens 2013 9:e1003184 DOI:10.1371/journal.ppat.1003184 PMID:23468626 PMCID:PMC3585149
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Gach, J. S., Leaman, D. P., Zwick, M. B.
Targeting HIV-1 gp41 in close proximity to the membrane using antibody and other molecules
Current Topics in Medicinal Chemistry
2011
11:2997-3021
DOI:10.2174/156802611798808505
PMID:22044228
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Agrawal, N., Leaman, D. P., Rowcliffe, E., Kinkead, H., Nohria, R., Akagi, J., Bauer, K., Du, S. X., Whalen, R. G., Burton, D. R., Zwick, M. B.
Functional stability of unliganded envelope glycoprotein spikes among isolates of human immunodeficiency virus type 1 (HIV-1)
PLoS One
2011
6:e21339
DOI:10.1371/journal.pone.0021339
PMID:21738637
PMCID:PMC3124497
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Murray, E. J., Leaman, D. P., Pawa, N., Perkins, H., Pickford, C., Perros, M., Zwick, M. B., Butler, S. L.
A low-molecular-weight entry inhibitor of both CCR5- and CXCR4-tropic strains of human immunodeficiency virus type 1 targets a novel site on gp41
Journal of Virology
2010
84:7288-7299
DOI:10.1128/jvi.00535-10
PMID:20427524
PMCID:PMC2898251
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Leaman, D. P., Kinkead, H., Zwick, M. B.
In-solution virus capture assay helps deconstruct heterogeneous antibody recognition of human immunodeficiency virus type 1
Journal of Virology
2010
84:3382-3395
DOI:10.1128/jvi.02363-09
PMID:20089658
PMCID:PMC2838137
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Scherer, E. M., Leaman, D. P., Zwick, M. B., McMichael, A. J., Burton, D. R.
Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions
Proceedings of the National Academy of Sciences of the United States of America
2010
107:1529-1534
DOI:10.1073/pnas.0909680107
PMID:20080706
PMCID:PMC2824387
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Reynolds, M. R., Weiler, A. M., Weisgrau, K. L., Piaskowski, S. M., Furlott, J. R., Weinfurter, J. T., Kaizu, M., Soma, T., Leon, E. J., MacNair, C., Leaman, D. P., Zwick, M. B., et al.
Macaques vaccinated with live-attenuated SIV control replication of heterologous virus
Journal of Experimental Medicine
2008
205:2537-2550
DOI:10.1084/jem.20081524
PMID:18838548
PMCID:PMC2571929
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Nelson, J. D., Kinkead, H., Brunel, F. M., Leaman, D., Jensen, R., Louis, J. M., Maruyama, T., Bewley, C. A., Bowdish, K., Clore, G. M., Dawson, P. E., Frederickson, S., et al.
Antibody elicited against the gp41 N-heptad repeat (NHR) coiled-coil can neutralize HIV-1 with modest potency but non-neutralizing antibodies also bind to NHR mimetics
Virology
2008
377:170-183
DOI:10.1016/j.virol.2008.04.005
PMID:18499210
PMCID:PMC2493441
- Kurant, E., Axelrod, S., Leaman, D., Gaul, U. Six-microns-under acts upstream of Draper in the glial phagocytosis of apoptotic neurons Cell 2008 133:498-509 DOI:10.1016/j.cell.2008.02.052 PMID:18455990 PMCID:PMC2730188
- Leaman, D., Chen, P. Y., Fak, J., Yalcin, A., Pearce, M., Unnerstall, U., Marks, D. S., Sander, C., Tuschl, T., Gaul, U. Antisense-mediated depletion reveals essential and specific functions of microRNAs in Drosophila development Cell 2005 121:1097-1108 DOI:10.1016/j.cell.2005.04.016 PMID:15989958