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Lazzerini Denchi, Eros
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Lazzerini Denchi, Eros

Faculty Member
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Positions

  • 2017 - Associate Professor, Molecular Medicine , Scripps Research
  • 2008 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2015 - 2017 Associate Professor, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2015 - 2017 Associate Professor (Joint Appointment), Cell and Molecular Biology (CMB) , Scripps Research
  • 2013 - 2015 Assistant Professor (Joint Appointment), Cell and Molecular Biology (CMB) , Scripps Research
  • 2012 - 2015 Assistant Professor, Molecular and Experimental Medicine (MEM) , Scripps Research
  • 2008 - 2011 Assistant Professor, Genetics , Scripps Research
  • - 2007 Postdoctoral Fellow with Dr. Titia de Lange, The Rockefeller University
Dr. Eros Lazzerini Denchi focuses on the mechanisms that protect chromosome ends and their deregulation in human pathologies such as cancer and aging.

Research Areas research areas

  • Cancer (UMLS)

Contact

  • edenchi@scripps.edu

Websites

  • Eros Lazzerini Denchi, Ph.D.
  • Laboratory Website
  • Publications
  • Research
  • Teaching
  • Background
  • Contact
  • Identity
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Publications

recent publications
  • All Publications
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  • Publications without PubMed PMIDs

  • academic article

    • Li, J. S. Z., Denchi, E. L. How stem cells keep telomeres in check Differentiation  2018 100:21-25  DOI:10.1016/j.diff.2018.01.004  PMID:29413749  PMCID:PMC5889314
    • Li, J. S., Fuste, J. M., Simavorian, T., Bartocci, C., Tsai, J., Karlseder, J., Denchi, E. L. TZAP: A telomere-associated protein involved in telomere length control Science  2017 355:638-+  DOI:10.1126/science.aah6752  PMID:28082411  PMCID:PMC5518674
    • Lazzerini-Denchi, E., Sfeir, A. Stop pulling my strings - what telomeres taught us about the DNA damage response Nature Reviews Molecular Cell Biology  2016 17:364-378  DOI:10.1038/nrm.2016.43  PMID:27165790
    • Mateos-Gomez, P. A., Gong, F., Nair, N., Miller, K. M., Lazzerini-Denchi, E., Sfeir, A. Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination Nature  2015 518:254-257  DOI:10.1038/nature14157  PMID:25642960  PMCID:PMC4718306
    • Bartocci, C., Diedrich, J. K., Ouzounov, I., Li, J., Piunti, A., Pasini, D., Yates III, J. R., Denchi, E. L. Isolation of chromatin from dysfunctional telomeres reveals an important role for Ring1b in NHEJ-mediated chromosome fusions Cell Reports  2014 7:1320-1332  DOI:10.1016/j.celrep.2014.04.002  PMID:24813883  PMCID:PMC4054697
    • Denchi, E. L., Li, J. Let it go: how to deal with a breakup in mitosis Nature Structural & Molecular Biology  2014 21:433-435  DOI:10.1038/nsmb.2825  PMID:24799037
    • Groocock, L. M., Nie, M., Prudden, J., Moiani, D., Wang, T., Cheltsov, A., Rambo, R. P., Arvai, A. S., Hitomi, C., Tainer, J. A., Luger, K., Perry, J. J. P., et al. RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response EMBO Reports  2014 15:601-608  DOI:10.1002/embr.201338369  PMID:24714598  PMCID:PMC4210088
    • Bekes, M., Okamoto, K., Crist, S. B., Jones, M. J., Chapman, J. R., Brasher, B. B., Melandri, F. D., Ueberheide, B. M., Denchi, E. L., Huang, T. T. DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells Cell Reports  2013 5:826-838  DOI:10.1016/j.celrep.2013.10.008  PMID:24210823  PMCID:PMC3889155
    • Okamoto, K., Bartocci, C., Ouzounov, I., Diedrich, J. K., Yates, J. R., Denchi, E. L. A two-step mechanism for TRF2-mediated chromosome-end protection Nature  2013 494:502-505  DOI:10.1038/nature11873  PMID:23389450  PMCID:PMC3733551
    • Bopp, S. E. R., Manary, M. J., Bright, A. T., Johnston, G. L., Dharia, N. V., Luna, F. L., McCormack, S., Plouffe, D., McNamara, C. W., Walker, J. R., Fidock, D. A., Denchi, E. L., et al. Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families PLoS Genetics  2013 9:e1003293  DOI:10.1371/journal.pgen.1003293  PMID:23408914  PMCID:PMC3567157
    • Bartocci, C., Denchi, E. L. Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites Frontiers in Genetics  2013 4:128  DOI:10.3389/fgene.2013.00128  PMID:23847653  PMCID:PMC3705210
    • Denchi, E. L. A critical role for TORC1 in cellular senescence Cell Cycle  2012 11:2976  DOI:10.4161/cc.21529  PMID:22874595  PMCID:PMC3442903
    • Hayashi, M. T., Cesare, A. J., Fitzpatrick, J. A. J., Lazzerini-Denchi, E., Karlseder, J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest Nature Structural & Molecular Biology  2012 19:387-394  DOI:10.1038/nsmb.2245  PMID:22407014  PMCID:PMC3319806
    • Denchi, E. L. New players in end-protection: LIM-domain proteins associate with the shelterin complex Aging  2010 2:390-391  PMID:20639580  PMCID:PMC2933886
    • Davoli, T., Denchi, E. L., de Lange, T. Persistent telomere damage induces bypass of mitosis and tetraploidy Cell  2010 141:81-93  DOI:10.1016/j.cell.2010.01.031  PMID:20371347  PMCID:PMC2854042
    • Denchi, E. L. Give me a break: how telomeres suppress the DNA damage response DNA Repair  2009 8:1118-1126  DOI:10.1016/j.dnarep.2009.04.013  PMID:19482563
    • Denchi, E. L., de Lange, T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1 Nature  2007 448:1068-1071  DOI:10.1038/nature06065  PMID:17687332
    • Denchi, E. L., Celli, G., de Lange, T. Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication Genes & Development  2006 20:2648-2653  DOI:10.1101/gad.1453606  PMID:17015429  PMCID:PMC1578691
    • Celli, G. B., Denchi, E. L., de Lange, T. Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination Nature Cell Biology  2006 8:885-890  DOI:10.1038/ncb1444  PMID:16845382
    • Colombo, E., Bonetti, P., Denchi, E. L., Martinelli, P., Zamponi, R., Marine, J. C., Helin, K., Falini, B., Pelicci, P. G. Nucleophosmin is required for DNA integrity and p19(Arf) protein stability Molecular and Cellular Biology  2005 25:8874-8886  DOI:10.1128/mcb.25.20.8874-8886.2005  PMID:16199867  PMCID:PMC1265791
    • Denchi, E. L., Helin, K. E2F1 is crucial for E2F-dependent apoptosis EMBO Reports  2005 6:661-668  DOI:10.1038/sj.embor.7400452  PMID:15976820  PMCID:PMC1369111
    • Denchi, E. L., Attwooll, C., Pasini, D., Helin, K. Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland Molecular and Cellular Biology  2005 25:2660-2672  DOI:10.1128/mcb.25.7.2660-2672.2005  PMID:15767672  PMCID:PMC1061636
    • Attwooll, C., Denchi, E. L., Helin, K. The E2F family: specific functions and overlapping interests EMBO Journal  2004 23:4709-4716  DOI:10.1038/sj.emboj.7600481  PMID:15538380  PMCID:PMC535093
    • Pasini, D., Bracken, A. P., Jensen, M. R., Denchi, E. L., Helin, K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity EMBO Journal  2004 23:4061-4071  DOI:10.1038/sj.emboj.7600402  PMID:15385962  PMCID:PMC524339
    • Trinh, E., Denchi, E. L., Helin, K. Naturally death-resistant precursor cells revealed as the origin of retinoblastoma Cancer Cell  2004 5:513-515  DOI:10.1016/j.ccr.2004.05.026  PMID:15193252
    • Migliorini, D., Denchi, E. L., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P. G., Marine, J. C. Mdm4 (mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development Molecular and Cellular Biology  2002 22:5527-5538  DOI:10.1128/mcb.22.15.5527-5538.2002  PMID:12101245  PMCID:PMC133932
    • Moroni, M. C., Hickman, E. S., Denchi, E. L., Caprara, G., Colli, E., Cecconi, F., Muller, H., Helin, K. Apaf-1 is a transcriptional target for E2F and p53 Nature Cell Biology  2001 3:552-558  DOI:10.1038/35078527  PMID:11389439
    • Petersen, B. O., Wagener, C., Marinoni, F., Kramer, E. R., Melixetian, M., Denchi, E. L., Gieffers, C., Matteucci, C., Peters, J. M., Helin, K. Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1 Genes & Development  2000 14:2330-2343  DOI:10.1101/gad.832500  PMID:10995389  PMCID:PMC316932
  • thesis

    • Role of E2F in senescence and apoptosis induction 2004

featured in

  • Eros Lazzerini Denchi Named Pew Scholar in the BioMedical Sciences  Newsletter
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Research

research overview

  • Our lab is interested in two essential mechanisms that ensure genomic stability in mammalian cells:

    Protection of chromosome ends

    Because of their linear organization the terminal portion of mammalian chromosomes are unstable and can be processed by the DNA damage repair machinery resulting in genomic instability. Specialized nucleoprotein complexes termed telomeres suppress these deleterious events. During the onset of several human pathologies, such as cancer and aging, cells lose the ability to efficiently protect their chromosome ends and thus accumulate high levels of genomic instability. Research in our laboratory aims to elucidate the mechanisms by which telomeres can suppress the DNA damage response in normal cells and how these mechanisms are deregulated in human pathologies.

    Cell type specific cell fate in response to DNA damage

    A complementary approach in the lab is to understand what factors affect the cellular response to telomere deprotection. To this end we use mouse genetics to probe the cellular fate of terminally differentiated as well as multipotent stem cells to telomere deprotection.

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Teaching

advisees

  • graduate advising relationship

    • Loe, Taylor Kristine, Ph.D.  candidate, 2016 -
    • Li, Julia Su Zhou, Ph.D.  candidate, 2014 - 2018
    • Lobanova, Anastasia, M.A.  candidate, 2015 - 2018
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Background

education and training

  • Ph.D. in Cancer Biology, The Open University in London , European Institute of Oncology, with Dr. Kristian Helin 2004
  • B.S. in Molecular Biology, University of Milan 2000
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Contact

full name

  • Eros Lazzerini Denchi

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0001-5378-4644

ResearcherID (Thomson Reuters)

  • F-7913-2010

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