recent publications
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academic article
- Li, J. S. Z., Denchi, E. L. How stem cells keep telomeres in check Differentiation 2018 100:21-25 DOI:10.1016/j.diff.2018.01.004 PMID:29413749 PMCID:PMC5889314
- Li, J. S., Fuste, J. M., Simavorian, T., Bartocci, C., Tsai, J., Karlseder, J., Denchi, E. L. TZAP: A telomere-associated protein involved in telomere length control Science 2017 355:638-+ DOI:10.1126/science.aah6752 PMID:28082411 PMCID:PMC5518674
- Lazzerini-Denchi, E., Sfeir, A. Stop pulling my strings - what telomeres taught us about the DNA damage response Nature Reviews Molecular Cell Biology 2016 17:364-378 DOI:10.1038/nrm.2016.43 PMID:27165790
- Mateos-Gomez, P. A., Gong, F., Nair, N., Miller, K. M., Lazzerini-Denchi, E., Sfeir, A. Mammalian polymerase theta promotes alternative NHEJ and suppresses recombination Nature 2015 518:254-257 DOI:10.1038/nature14157 PMID:25642960 PMCID:PMC4718306
- Bartocci, C., Diedrich, J. K., Ouzounov, I., Li, J., Piunti, A., Pasini, D., Yates III, J. R., Denchi, E. L. Isolation of chromatin from dysfunctional telomeres reveals an important role for Ring1b in NHEJ-mediated chromosome fusions Cell Reports 2014 7:1320-1332 DOI:10.1016/j.celrep.2014.04.002 PMID:24813883 PMCID:PMC4054697
- Denchi, E. L., Li, J. Let it go: how to deal with a breakup in mitosis Nature Structural & Molecular Biology 2014 21:433-435 DOI:10.1038/nsmb.2825 PMID:24799037
- Groocock, L. M., Nie, M., Prudden, J., Moiani, D., Wang, T., Cheltsov, A., Rambo, R. P., Arvai, A. S., Hitomi, C., Tainer, J. A., Luger, K., Perry, J. J. P., et al. RNF4 interacts with both SUMO and nucleosomes to promote the DNA damage response EMBO Reports 2014 15:601-608 DOI:10.1002/embr.201338369 PMID:24714598 PMCID:PMC4210088
- Bekes, M., Okamoto, K., Crist, S. B., Jones, M. J., Chapman, J. R., Brasher, B. B., Melandri, F. D., Ueberheide, B. M., Denchi, E. L., Huang, T. T. DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells Cell Reports 2013 5:826-838 DOI:10.1016/j.celrep.2013.10.008 PMID:24210823 PMCID:PMC3889155
- Okamoto, K., Bartocci, C., Ouzounov, I., Diedrich, J. K., Yates, J. R., Denchi, E. L. A two-step mechanism for TRF2-mediated chromosome-end protection Nature 2013 494:502-505 DOI:10.1038/nature11873 PMID:23389450 PMCID:PMC3733551
- Bopp, S. E. R., Manary, M. J., Bright, A. T., Johnston, G. L., Dharia, N. V., Luna, F. L., McCormack, S., Plouffe, D., McNamara, C. W., Walker, J. R., Fidock, D. A., Denchi, E. L., et al. Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families PLoS Genetics 2013 9:e1003293 DOI:10.1371/journal.pgen.1003293 PMID:23408914 PMCID:PMC3567157
- Bartocci, C., Denchi, E. L. Put a RING on it: regulation and inhibition of RNF8 and RNF168 RING finger E3 ligases at DNA damage sites Frontiers in Genetics 2013 4:128 DOI:10.3389/fgene.2013.00128 PMID:23847653 PMCID:PMC3705210
- Denchi, E. L. A critical role for TORC1 in cellular senescence Cell Cycle 2012 11:2976 DOI:10.4161/cc.21529 PMID:22874595 PMCID:PMC3442903
- Hayashi, M. T., Cesare, A. J., Fitzpatrick, J. A. J., Lazzerini-Denchi, E., Karlseder, J. A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest Nature Structural & Molecular Biology 2012 19:387-394 DOI:10.1038/nsmb.2245 PMID:22407014 PMCID:PMC3319806
- Denchi, E. L. New players in end-protection: LIM-domain proteins associate with the shelterin complex Aging 2010 2:390-391 PMID:20639580 PMCID:PMC2933886
- Davoli, T., Denchi, E. L., de Lange, T. Persistent telomere damage induces bypass of mitosis and tetraploidy Cell 2010 141:81-93 DOI:10.1016/j.cell.2010.01.031 PMID:20371347 PMCID:PMC2854042
- Denchi, E. L. Give me a break: how telomeres suppress the DNA damage response DNA Repair 2009 8:1118-1126 DOI:10.1016/j.dnarep.2009.04.013 PMID:19482563
- Denchi, E. L., de Lange, T. Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1 Nature 2007 448:1068-1071 DOI:10.1038/nature06065 PMID:17687332
- Denchi, E. L., Celli, G., de Lange, T. Hepatocytes with extensive telomere deprotection and fusion remain viable and regenerate liver mass through endoreduplication Genes & Development 2006 20:2648-2653 DOI:10.1101/gad.1453606 PMID:17015429 PMCID:PMC1578691
- Celli, G. B., Denchi, E. L., de Lange, T. Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination Nature Cell Biology 2006 8:885-890 DOI:10.1038/ncb1444 PMID:16845382
- Colombo, E., Bonetti, P., Denchi, E. L., Martinelli, P., Zamponi, R., Marine, J. C., Helin, K., Falini, B., Pelicci, P. G. Nucleophosmin is required for DNA integrity and p19(Arf) protein stability Molecular and Cellular Biology 2005 25:8874-8886 DOI:10.1128/mcb.25.20.8874-8886.2005 PMID:16199867 PMCID:PMC1265791
- Denchi, E. L., Helin, K. E2F1 is crucial for E2F-dependent apoptosis EMBO Reports 2005 6:661-668 DOI:10.1038/sj.embor.7400452 PMID:15976820 PMCID:PMC1369111
- Denchi, E. L., Attwooll, C., Pasini, D., Helin, K. Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland Molecular and Cellular Biology 2005 25:2660-2672 DOI:10.1128/mcb.25.7.2660-2672.2005 PMID:15767672 PMCID:PMC1061636
- Attwooll, C., Denchi, E. L., Helin, K. The E2F family: specific functions and overlapping interests EMBO Journal 2004 23:4709-4716 DOI:10.1038/sj.emboj.7600481 PMID:15538380 PMCID:PMC535093
- Pasini, D., Bracken, A. P., Jensen, M. R., Denchi, E. L., Helin, K. Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity EMBO Journal 2004 23:4061-4071 DOI:10.1038/sj.emboj.7600402 PMID:15385962 PMCID:PMC524339
- Trinh, E., Denchi, E. L., Helin, K. Naturally death-resistant precursor cells revealed as the origin of retinoblastoma Cancer Cell 2004 5:513-515 DOI:10.1016/j.ccr.2004.05.026 PMID:15193252
- Migliorini, D., Denchi, E. L., Danovi, D., Jochemsen, A., Capillo, M., Gobbi, A., Helin, K., Pelicci, P. G., Marine, J. C. Mdm4 (mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development Molecular and Cellular Biology 2002 22:5527-5538 DOI:10.1128/mcb.22.15.5527-5538.2002 PMID:12101245 PMCID:PMC133932
- Moroni, M. C., Hickman, E. S., Denchi, E. L., Caprara, G., Colli, E., Cecconi, F., Muller, H., Helin, K. Apaf-1 is a transcriptional target for E2F and p53 Nature Cell Biology 2001 3:552-558 DOI:10.1038/35078527 PMID:11389439
- Petersen, B. O., Wagener, C., Marinoni, F., Kramer, E. R., Melixetian, M., Denchi, E. L., Gieffers, C., Matteucci, C., Peters, J. M., Helin, K. Cell cycle- and cell growth-regulated proteolysis of mammalian CDC6 is dependent on APC-CDH1 Genes & Development 2000 14:2330-2343 DOI:10.1101/gad.832500 PMID:10995389 PMCID:PMC316932
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thesis
