recent publications
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academic article
- Gingipalli, L., Block, M. H., Bao, L., Cooke, E., Dakin, L. A., Denz, C. R., Ferguson, A. D., Johannes, J. W., Larsen, N. A., Lyne, P. D., Pontz, T. W., Wang, T., et al. Discovery of 2,6-disubstituted pyrazine derivatives as inhibitors of CK2 and PIM kinases Bioorganic & Medicinal Chemistry Letters 2018 28:1336-1341 DOI:10.1016/j.bmcl.2018.03.018 PMID:29559278
- Finci, L. I., Zhang, X., Huang, X., Zhou, Q., Tsai, J., Teng, T., Agrawal, A., Chan, B., Irwin, S., Karr, C., Cook, A., Zhu, P., et al. The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action Genes & Development 2018 32:309-320 DOI:10.1101/gad.311043.117 PMID:29491137 PMCID:PMC5859971
- van Strijp, D., Vulders, R. C. M., Larsen, N. A., Schira, J., Baerlocher, L., van Driel, M. A., Podenphant, M., Hansen, T. S., Kristensen, A., Mir, K. U., Olesen, T., Verhaegh, W. F. J., et al. Complete sequence-based pathway analysis by differential on-chip DNA and RNA extraction from a single cell Scientific Reports 2017 7 DOI:10.1038/s41598-017-10704-4 PMID:28887473 PMCID:PMC5591254
- Cowen, S. D., Russell, D., Dakin, L. A., Chen, H., Larsen, N. A., Godin, R., Throner, S., Zheng, X., Molina, A., Wu, J., Cheung, T., Howard, T., et al. Design, synthesis, and biological activity of substrate competitive SMYD2 inhibitors Journal of Medicinal Chemistry 2016 59:11079-11097 DOI:10.1021/acs.jmedchem.6b01303 PMID:28002961
- Dowling, J. E., Alimzhanov, M., Bao, L., Chuaqui, C., Denz, C. R., Jenkins, E., Larsen, N. A., Lyne, P. D., Pontz, T., Ye, Q., Holdgate, G. A., Snow, L., et al. Potent and selective CK2 kinase inhibitors with effects on Wnt pathway signaling in vivo ACS Medicinal Chemistry Letters 2016 7:300-305 DOI:10.1021/acsmedchemlett.5b00452 PMID:26985319 PMCID:PMC4789659
- Johannes, J. W., Almeida, L., Daly, K., Ferguson, A. D., Grosskurth, S. E., Guan, H., Howard, T., Ioannidis, S., Kazmirski, S., Lamb, M. L., Larsen, N. A., Lyne, P. D., et al. Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering Bioorganic & Medicinal Chemistry Letters 2015 25:5743-5747 DOI:10.1016/j.bmcl.2015.10.079 PMID:26546219
- Wu, J., Powell, F., Larsen, N. A., Lai, Z., Byth, K. F., Read, J., Gu, R. F., Roth, M., Toader, D., Saeh, J. C., Chen, H. Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol ACS Chemical Biology 2013 8:643-650 DOI:10.1021/cb3005897 PMID:23272696
- Dowling, J. E., Alimzhanov, M., Bao, L., Block, M. H., Chuaqui, C., Cooke, E. L., Denz, C. R., Hird, A., Huang, S., Larsen, N. A., Peng, B., Pontz, T. W., et al. Structure and property based design of pyrazolo 1,5-a pyrimidine inhibitors of CK2 kinase with activity in vivo ACS Medicinal Chemistry Letters 2013 4:800-805 DOI:10.1021/ml400197u PMID:24900749 PMCID:PMC4027246
- Larsen, N. A., Nash, T. J., Morningstar, M., Shapiro, A. B., Joubran, C., Blackett, C. J., Patten, A. D., Boriack-Sjodin, P. A., Doig, P. An aminoquinazoline inhibitor of the essential bacterial cell wall synthetic enzyme GlmU has a unique non-protein-kinase-like binding mode Biochemical Journal 2012 446:405-413 DOI:10.1042/bj20120596 PMID:22721802
- Hennessy, E. J., Saeh, J. C., Sha, L., MacIntyre, T., Wang, H., Larsen, N. A., Aquila, B. M., Ferguson, A. D., Laing, N. M., Omer, C. A. Discovery of aminopiperidine-based Smac mimetics as IAP antagonists Bioorganic & Medicinal Chemistry Letters 2012 22:1690-1694 DOI:10.1016/j.bmcl.2011.12.109 PMID:22264476
- Wang, T., Block, M. A., Cowen, S., Davies, A. M., Devereaux, E., Gingipalli, L., Johannes, J., Larsen, N. A., Su, Q., Tucker, J. A., Whitston, D., Wu, J., et al. Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases Bioorganic & Medicinal Chemistry Letters 2012 22:2063-2069 DOI:10.1016/j.bmcl.2012.01.018 PMID:22305584
- Martinez-Botella, G., Breen, J. N., Duffy, J. E. S., Dumas, J., Geng, B. L., Gowers, I. K., Green, O. M., Guler, S., Hentemann, M. F., Hernandez-Juan, F. A., Joseph-McCarthy, D., Kawatkar, S., et al. Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK) Journal of Medicinal Chemistry 2012 55:10010-10021 DOI:10.1021/jm3011806 PMID:23043329
- Dowling, J. E., Chuaqui, C., Pontz, T. W., Lyne, P. D., Larsen, N. A., Block, M. H., Chen, H., Su, N., Wu, A., Russell, D., Pollard, H., Lee, J. W., et al. Potent and selective inhibitors of CK2 kinase identified through structure-guided hybridization ACS Medicinal Chemistry Letters 2012 3:278-283 DOI:10.1021/ml200257n PMID:24900464 PMCID:PMC4025639
- Ferguson, A. D., Larsen, N. A., Howard, T., Pollard, H., Green, I., Grande, C., Cheung, T., Garcia-Arenas, R., Cowen, S., Wu, J., Godin, R., Chen, H., et al. Structural basis of substrate methylation and inhibition of SMYD2 Structure 2011 19:1262-1273 DOI:10.1016/j.str.2011.06.011 PMID:21782458
- Taga, M. E., Larsen, N. A., Howard-Jones, A. R., Walsh, C. T., Walker, G. C. BluB cannibalizes flavin to form the lower ligand of vitamin B-12 Nature 2007 446:449-453 DOI:10.1038/nature05611 PMID:17377583 PMCID:PMC2770582
- Al-Bassam, J., Larsen, N. A., Hyman, A. A., Harrison, S. C. Crystal structure of a TOG domain: Conserved features of XMAP215/Dis1-family TOG domains and implications for tubulin binding Structure 2007 15:355-362 DOI:10.1016/j.str.2007.01.012 PMID:17355870
- Larsen, N. A., Al-Bassam, J., Wei, R. R., Harrison, S. C. Structural analysis of Bub3 interactions in the mitotic spindle checkpoint Proceedings of the National Academy of Sciences of the United States of America 2007 104:1201-1206 DOI:10.1073/pnas.0610358104 PMID:17227844 PMCID:PMC1770893
- Larsen, N. A., Lin, H., Wei, R., Fischbach, M. A., Walsh, C. T. Structural characterization of enterobactin hydrolase IroE Biochemistry 2006 45:10184-10190 DOI:10.1021/bi060950i PMID:16922493
- Wei, R. R., Schnell, J. R., Larsen, N. A., Sorger, P. K., Chou, J. J., Harrison, S. C. Structure of a central component of the yeast kinetochore: The Spc24p/Spc25p globular domain Structure 2006 14:1003-1009 DOI:10.1016/j.str.2006.04.007 PMID:16765893
- Cooper, Z. D., Narasimhan, D., Sunahara, R. K., Mierzejewski, P., Jutkiewicz, E. M., Larsen, N. A., Wilson, I. A., Landry, D. W., Woods, J. H. Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase Molecular Pharmacology 2006 70:1885-1891 DOI:10.1124/mol.106.025999 PMID:16968810
- Larsen, N. A., Harrison, S. C. Crystal structure of the spindle assembly checkpoint protein Bub3 Journal of Molecular Biology 2004 344:885-892 DOI:10.1016/j.jmb.2004.09.094 PMID:15544799
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Larsen, N. A., de Prada, P., Deng, S. X., Mittal, A., Braskett, M., Zhu, X., Wilson, I. A., Landry, D. W.
Crystallographic and biochemical analysis of cocaine-degrading antibody l5a10
Biochemistry
2004
43:8067-8076
DOI:10.1021/bi0494951
PMID:15209502
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Redwan, E. R. M., Larsen, N. A., Zhou, B., Wirsching, P., Janda, K. D., Wilson, I. A.
Expression and characterization of a humanized cocaine-binding antibody
Biotechnology and Bioengineering
2003
82:612-618
DOI:10.1002/bit.10598
PMID:12652485
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Zhu, X. Y., Larsen, N. A., Basran, A., Bruce, N. C., Wilson, I. A.
Observation of an arsenic adduct in an acetyl esterase crystal structure
Journal of Biological Chemistry
2003
278:2008-2014
DOI:10.1074/jbc.M210103200
PMID:12421810
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Turner, J. M., Larsen, N. A., Basran, A., Barbas, C. F., Bruce, N. C., Wilson, I. A., Lerner, R. A.
Biochemical characterization and structural analysis of a highly proficient cocaine esterase
Biochemistry
2002
41:12297-12307
DOI:10.1021/bi026131p
PMID:12369817
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Larsen, N. A., Turner, J. M., Stevens, J., Rosser, S. J., Basran, A., Lerner, R. A., Bruce, N. C., Wilson, I. A.
Crystal structure of a bacterial cocaine esterase
Nature Structural Biology
2002
9:17-21
DOI:10.1038/nsb742
PMID:11742345
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Larsen, N. A., Heine, A., de Prada, P., Redwan, E. R., Yeates, T. O., Landry, D. W., Wilson, I. A.
Structure determination of a cocaine hydrolytic antibody from a pseudomerohedrally twinned crystal
Acta Crystallographica Section D-Biological Crystallography
2002
58:2055-2059
DOI:10.1107/s0907444902017420
PMID:12454464
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Wentworth, P., Jones, L. H., Wentworth, A. D., Zhu, X. Y., Larsen, N. A., Wilson, I. A., Xu, X., Goddard, W. A., Janda, K. D., Eschenmoser, A., Lerner, R. A.
Antibody catalysis of the oxidation of water
Science
2001
293:1806-1811
DOI:10.1126/science.1062722
PMID:11546867
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Larsen, N. A., Zhou, B., Heine, A., Wirsching, P., Janda, K. D., Wilson, I. A.
Crystal structure of a cocaine-binding antibody
Journal of Molecular Biology
2001
311:9-15
DOI:10.1006/jmbi.2001.4839
PMID:11469854
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Larsen, N. A., Heine, A., Crane, L., Cravatt, B. F., Lerner, R. A., Wilson, I. A.
Structural basis for a disfavored elimination reaction in catalytic antibody 1D4
Journal of Molecular Biology
2001
314:93-102
DOI:10.1006/jmbi.2001.5112
PMID:11724535
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Karlstrom, A., Zhong, G. F., Rader, C., Larsen, N. A., Heine, A., Fuller, R., List, B., Tanaka, F., Wilson, I. A., Barbas, C. F., Lerner, R. A.
Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task
Proceedings of the National Academy of Sciences of the United States of America
2000
97:3878-3883
DOI:10.1073/pnas.97.8.3878
PMID:10760259
- Pellegrini, M.*, Larsen, N. A.*, Yeates, T. O., Gronbech-Jensen, N. A new constrained Langevin method: application to protein crystallographic refinement Physica A 1998 261:224-231 DOI:10.1016/s0378-4371(98)00375-6 (* = equal contribution)