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Lander, Gabriel
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Lander, Gabriel

Faculty Member
Graduate Student
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Positions

  • 2019 - Professor, Integrative Structural and Computational Biology (ISCB) , Scripps Research
  • 2013 - Faculty Member, Skaggs Graduate School of Chemical and Biological Sciences , Scripps Research
  • 2017 - 2019 Associate Professor, Integrative Structural and Computational Biology (ISCB) , Scripps Research
  • 2013 - 2017 Assistant Professor, Integrative Structural and Computational Biology (ISCB) , Scripps Research
  • 2009 - 2013 Postdoctoral Fellow with Dr. Eva Nogales, University of California, Berkeley
  • 2003 - 2004 Intern, Scripps Research
  • 2003 - 2004 Genome Curator, Carnegie Institution (TAIR), Stanford University

Contact

  • glander@scripps.edu
  • (858) 784-8793

Websites

  • Gabriel Lander, Ph.D.
  • Doctoral Dissertation
  • Lander Laboratory
  • Twitter @LanderLab
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Publications

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  • academic article

    • Hirschi, M., Lu, W. T., Santiago-Frangos, A., Wilkinson, R., Golden, S. M., Davidson, A. R., Lander, G. C., Wiedenheft, B. AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex Nature Communications  2020 11  DOI:10.1038/s41467-020-16512-1  PMID:32483187  PMCID:PMC7264359
    • Fribourgh, J. L., Srivastava, A., Sandate, C. R., Michael, A. K., Hsu, P. L., Rakers, C., Nguyen, L. T., Torgrimson, M. R., Parico, G. C. G., Tripathi, S., Zheng, N., Lander, G. C., et al. Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing Elife  2020 9  DOI:10.7554/eLife.55275  PMID:32101164  PMCID:PMC7064333
    • Wu, M., Lander, G. C. How low can we go? Structure determination of small biological complexes using single-particle cryo-EM Current Opinion in Structural Biology  2020 64:9-16  DOI:10.1016/j.sbi.2020.05.007  PMID:32599507  PMCID:PMC7666008
    • Wu, M., Lander, G. C. Present and Emerging Methodologies in Cryo-EM Single-Particle Analysis Biophysical Journal  2020 119:1281-1289  DOI:10.1016/j.bpj.2020.08.027  PMID:32919493  PMCID:PMC7567993
    • Puchades, C., Sandate, C. R., Lander, G. C. The molecular principles governing the activity and functional diversity of AAA plus proteins Nature Reviews Molecular Cell Biology  2020 21:43-58  DOI:10.1038/s41580-019-0183-6  PMID:31754261
    • Greene, E. R., Goodall, E. A., de la Pena, A. H., Matyskiela, M. E., Lander, G. C., Martin, A. Specific lid-base cot :acts in the 26s proteasome control the conformational switching required for substrate degradation Elife  2019 8  DOI:10.7554/eLife.49806
    • Grotjahn, D. A., Lander, G. C. Setting the dynein motor in motion: New insights from electron tomography Journal of Biological Chemistry  2019 294:13202-13217  DOI:10.1074/jbc.REV119.003095  PMID:31285262  PMCID:PMC6737236
    • Puchades, C., Ding, B. J., Song, A., Wiseman, R. L., Lander, G. C., Glynn, S. E. Unique structural features of the mitochondrial AAA+ protease AFG3L2 reveal the molecular basis for activity in health and disease Molecular Cell  2019 75:1073-1085  DOI:10.1016/j.molcel.2019.06.016  PMID:31327635  PMCID:PMC6731152
    • Yin, Y., Wu, M., Hsw, A. L., Borschel, W. F., Borgnia, M. J., Lander, G. C., Lee, S. Y. Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel Nature Communications  2019 10  DOI:10.1038/s41467-019-11733-5  PMID:31431622  PMCID:PMC6702222
    • Sandate, C. R., Szyk, A., Zehr, E. A., Lander, G. C., Roll-Mecak, A. An allosteric network in spastin couples multiple activities required for microtubule severing Nature Structural & Molecular Biology  2019 26:671-678  DOI:10.1038/s41594-019-0257-3  PMID:31285604
    • Rollins, M. F., Chowdhury, S., Carter, J., Golden, S. M., Miettinen, H. M., Santiago-Frangos, A., Faith, D., Lawrence, C. M., Lander, G. C., Wiedenheft, B. Structure reveals a mechanism of CRISPR-RNA-guided nuclease recruitment and anti-CRISPR viral mimicry Molecular Cell  2019 74:132-142  DOI:10.1016/j.molcel.2019.02.001  PMID:30872121
    • Herzik Jr., M. A.*, Wu, M.*, Lander, G. C. High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM Nature Communications  2019 10  DOI:10.1038/s41467-019-08991-8  PMID:30833564  PMCID:PMC6399227 (* = equal contribution)
    • Herzik Jr., M. A., Fraser, J. S., Lander, G. C. A multi-model approach to assessing local and global Cryo-EM map quality Structure  2019 27:344-358  DOI:10.1016/j.str.2018.10.003  PMID:30449687  PMCID:PMC6365196
    • de la Pena, A. H., Goodall, E. A., Gates, S. N., Lander, G. C., Martin, A. Substrate-engaged 26S proteasome structures reveal mechanisms for ATP-hydrolysis-driven translocation Science  2018 362  DOI:10.1126/science.aav0725  PMID:30309908
    • Zubcevic, L., Herzik, M. A., Wu, M., Borschel, W. F., Hirschi, M., Song, A. S., Lander, G. C., Lee, S. Y. Conformational ensemble of the human TRPV3 ion channel Nature Communications  2018 9  DOI:10.1038/s41467-018-07117-w  PMID:30429472  PMCID:PMC6235889
    • Chowdhury, S., Otomo, C., Leitner, A., Ohashi, K., Aebersold, R., Lander, G. C., Otomo, T. Insights into autophagosome biogenesis from structural and biochemical analyses of the ATG2A-WIPI4 complex Proceedings of the National Academy of Sciences of the United States of America  2018 115:E9792-E9801  DOI:10.1073/pnas.1811874115  PMID:30185561  PMCID:PMC6196511
    • Yoo, J.*, Wu, M.*, Yin, Y., Herzik, M. A., Lander, G. C., Lee, S. Y. Cryo-EM structure of a mitochondrial calcium uniporter Science  2018 361:506-511  DOI:10.1126/science.aar4056  PMID:29954988 (* = equal contribution)
    • Bruggemann, J., Lander, G. C., Su, A. I. Exploring applications of crowdsourcing to cryo-EM Journal of Structural Biology  2018 203:37-45  DOI:10.1016/j.jsb.2018.02.006  PMID:29486249
    • Yin, Y.*, Wu, M.*, Zubcevic, L., Borschel, W. F., Lander, G. C., Lee, S. Y. Structure of the cold- and menthol-sensing ion channel TRPM8 Science  2018 359:237-241  DOI:10.1126/science.aan4325  PMID:29217583 (* = equal contribution)
    • Gardner, B. M., Castanzo, D. T., Chowdhury, S., Stjepanovic, G., Stefely, M. S., Hurley, J. H., Lander, G. C., Martin, A. The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading Nature Communications  2018 9  DOI:10.1038/s41467-017-02474-4  PMID:29321502  PMCID:PMC5762779
    • Grotjahn, D. A., Chowdhury, S., Xu, Y., McKenney, R. J., Schroer, T. A., Lander, G. C. Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility Nature Structural & Molecular Biology  2018 25:203-+  DOI:10.1038/s41594-018-0027-7  PMID:29416113
    • Puchades, C., Rampello, A. J., Shin, M., Giuliano, C. J., Wiseman, R. L., Glynn, S. E., Lander, G. C. Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing Science  2017 358  DOI:10.1126/science.aao0464  PMID:29097521
    • Hirschi, M., Herzik Jr., M. A., Wie, J., Suo, Y., Borschel, W. F., Ren, D., Lander, G. C., Lee, S. Y. Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3 Nature  2017 550:411-414  DOI:10.1038/nature24055
    • Chen, K. C., Qu, S., Chowdhury, S., Noxon, I. C., Schonhoft, J. D., Plate, L., Powers, E. T., Kelly, J. W., Lander, G. C., Wiseman, R. L. The endoplasmic reticulum HSP40 co-chaperone ERdj3/DNAJB11 assembles and functions as a tetramer EMBO Journal  2017 36:2296-2309  DOI:10.15252/embj.201695616
    • Rollins, M. F., Chowdhury, S., Carter, J., Golden, S. M., Wilkinson, R. A., Bondy-Denomy, J., Lander, G. C., Wiedenheft, B. Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity Proceedings of the National Academy of Sciences of the United States of America  2017 114:E5113-E5121  DOI:10.1073/pnas.1616395114  PMID:28438998  PMCID:PMC5495223
    • Chowdhury, S., Carter, J., Rollins, M. F., Golden, S. M., Jackson, R. N., Hoffmann, C., Nosaka, L., Bondy-Denomy, J., Maxwell, K. L., Davidson, A. R., Fischer, E. R., Lander, G. C., et al. Structure reveals mechanisms of viral suppressors that intercept a CRISPR RNA-guided surveillance complex Cell  2017 169:47-57  DOI:10.1016/j.cell.2017.03.012  PMID:28340349
    • Herzik Jr., M. A.*, Wu, M.*, Lander, G. C. Achieving better-than-3-Å resolution by single-particle cryo-EM at 200 keV Nature Methods  2017 14:1075-1078  DOI:10.1038/nmeth.4461  PMID:28991891  PMCID:PMC5679434 (* = equal contribution)
    • de la Pena, A. H., Lander, G. C. What's the key to unlocking the proteasome's gate? Structure  2016 24:2037-2038  DOI:10.1016/j.str.2016.11.011  PMID:27926830
    • Smirnova, I. A., Sjostrand, D., Li, F., Bjorck, M., Schafer, J., Ostbye, H., Hogbom, M., von Ballmoos, C., Lander, G. C., Adelroth, P., Brzezinski, P. Isolation of yeast complex IV in native lipid nanodiscs Biochimica et Biophysica Acta-Biomembranes  2016 1858:2984-2992  DOI:10.1016/j.bbamem.2016.09.004  PMID:27620332
    • Matyskiela, M. E., Lu, G., Ito, T., Pagarigan, B., Lu, C. C., Miller, K., Fang, W., Wang, N. Y., Nguyen, D., Houston, J., Carmel, G., Tran, T., et al. A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase Nature  2016 535:252-257  DOI:10.1038/nature18611  PMID:27338790
    • Zubcevic, L., Herzik, M. A., Chung, B. C., Liu, Z., Lander, G. C., Lee, S. Y. Cryo-electron microscopy structure of the TRPV2 ion channel Nature Structural & Molecular Biology  2016 23:180-186  DOI:10.1038/nsmb.3159  PMID:26779611  PMCID:PMC4876856
    • Dambacher, C. M., Worden, E. J., Herzik, M. A., Martin, A., Lander, G. C. Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition Elife  2016 5  DOI:10.7554/eLife.13027  PMID:26744777  PMCID:PMC4749569
    • Ciferri, C., Lander, G. C., Nogales, E. Protein domain mapping by internal labeling and single particle electron microscopy Journal of Structural Biology  2015 192:159-162  DOI:10.1016/j.jsb.2015.09.016  PMID:26431894  PMCID:PMC4921062
    • Dambacher, C. M., Lander, G. C. Site-specific labeling of proteins for electron microscopy Journal of Structural Biology  2015 192:151-158  DOI:10.1016/j.jsb.2015.09.010  PMID:26409249  PMCID:PMC4633364
    • Yang, T. C., Ortiz, D., Nosaka, L., Lander, G. C., Catalano, C. E. Thermodynamic interrogation of the assembly of a viral genome packaging motor complex Biophysical Journal  2015 109:1663-1675  DOI:10.1016/j.bpj.2015.08.037  PMID:26488657  PMCID:PMC4624345
    • McNulty, R., Lokareddy, R. K., Roy, A., Yang, Y., Lander, G. C., Heck, A. J. R., Johnson, J. E., Cingolani, G. Architecture of the complex formed by large and small terminase subunits from bacteriophage P22 Journal of Molecular Biology  2015 427:3285-3299  DOI:10.1016/j.jmb.2015.08.013  PMID:26301600  PMCID:PMC4587339
    • Bashore, C., Dambacher, C. M., Goodall, E. A., Matyskiela, M. E., Lander, G. C., Martin, A. Ubp6 deubiquitinase controls conformational dynamics and substrate degradation of the 26S proteasome Nature Structural & Molecular Biology  2015 22:712-719  DOI:10.1038/nsmb.3075  PMID:26301997  PMCID:PMC4560640
    • Garnham, C. P., Vemu, A., Wilson-Kubalek, E. M., Yu, I., Szyk, A., Lander, G. C., Milligan, R. A., Roll-Mecak, A. Multivalent microtubule recognition by tubulin tyrosine ligase-like family glutamylases Cell  2015 161:1112-1123  DOI:10.1016/j.cell.2015.04.003  PMID:25959773  PMCID:PMC4465277
    • Chowdhury, S., Ketcham, S. A., Schroer, T. A., Lander, G. C. Structural organization of the dynein-dynactin complex bound to microtubules Nature Structural & Molecular Biology  2015 22:345-347  DOI:10.1038/nsmb.2996  PMID:25751425  PMCID:PMC4385409
    • Gardner, B. M., Chowdhury, S., Lander, G. C., Martin, A. The Pex1/Pex6 complex is a heterohexameric AAA+ motor with alternating and highly coordinated subunits Journal of Molecular Biology  2015 427:1375-1388  DOI:10.1016/j.jmb.2015.01.019  PMID:25659908  PMCID:PMC4355278
    • Liu, T., Sae-Ueng, U., Li, D., Lander, G. C., Zuo, X., Jonsson, B., Rau, D., Shefer, I., Evilevitch, A. Solid-to-fluid-like DNA transition in viruses facilitates infection Proceedings of the National Academy of Sciences of the United States of America  2014 111:14675-14680  DOI:10.1073/pnas.1321637111  PMID:25271319  PMCID:PMC4205597
    • Alushin, G. M., Lander, G. C., Kellogg, E. H., Zhang, R., Baker, D., Nogales, E. High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis Cell  2014 157:1117-1129  DOI:10.1016/j.cell.2014.03.053  PMID:24855948  PMCID:PMC4054694
    • Zhao, Q., Potter, C. S., Carragher, B., Lander, G., Sworen, J., Towne, V., Abraham, D., Duncan, P., Washabaugh, M. W., Sitrin, R. D. Characterization of virus-like particles in GARDASIL by cryo transmission electron microscopy Human Vaccines & Immunotherapeutics  2014 10:734-739  DOI:10.4161/hv.27316  PMID:24299977  PMCID:PMC4130261
    • Matyskiela, M. E., Lander, G. C., Martin, A. Conformational switching of the 26S proteasome enables substrate degradation Nature Structural & Molecular Biology  2013 20:781-788  DOI:10.1038/nsmb.2616  PMID:23770819  PMCID:PMC3712289
    • degree-related publication Lander, G. C., Johnson, J. E., Rau, D. C., Potter, C. S., Carragher, B., Evilevitch, A. DNA bending-induced phase transition of encapsidated genome in phage λ Nucleic Acids Research  2013 41:4518-4524  DOI:10.1093/nar/gkt137  PMID:23449219  PMCID:PMC3632124
    • Lander, G. C., Martin, A., Nogales, E. The proteasome under the microscope: the regulatory particle in focus Current Opinion in Structural Biology  2013 23:243-251  DOI:10.1016/j.sbi.2013.02.004  PMID:23498601  PMCID:PMC3676703
    • Ciferri, C., Lander, G. C., Maiolica, A., Herzog, F., Aebersold, R., Nogales, E. Molecular architecture of human polycomb repressive complex 2 Elife  2012 1  DOI:10.7554/eLife.00005  PMID:23110252  PMCID:PMC3482686
    • Lander, G. C., Saibil, H. R., Nogales, E. Go hybrid: EM, crystallography, and beyond Current Opinion in Structural Biology  2012 22:627-635  DOI:10.1016/j.sbi.2012.07.006  PMID:22835744  PMCID:PMC3478466
    • Roy, A., Bhardwaj, A., Datta, P., Lander, G. C., Cingolani, G. Small terminase couples viral DNA binding to genome-packaging ATPase activity Structure  2012 20:1403-1413  DOI:10.1016/j.str.2012.05.014  PMID:22771211  PMCID:PMC3563279
    • degree-related publication Baudoux, A. C., Hendrix, R. W., Lander, G. C., Bailly, X., Podell, S., Paillard, C., Johnson, J. E., Potter, C. S., Carragher, B., Azam, F. Genomic and functional analysis of Vibrio phage SIO-2 reveals novel insights into ecology and evolution of marine siphoviruses Environmental Microbiology  2012 14:2071-2086  DOI:10.1111/j.1462-2920.2011.02685.x  PMID:22225728  PMCID:PMC3338904
    • degree-related publication Lander, G. C., Baudoux, A. C., Azam, F., Potter, C. S., Carragher, B., Johnson, J. E. Capsomer dynamics and stabilization in the T = 12 marine bacteriophage SIO-2 and its procapsid studied by CryoEM Structure  2012 20:498-503  DOI:10.1016/j.str.2012.01.007  PMID:22405008  PMCID:PMC3302160
    • Lander, G. C., Estrin, E., Matyskiela, M. E., Bashore, C., Nogales, E., Martin, A. Complete subunit architecture of the proteasome regulatory particle Nature  2012 482:186-191  DOI:10.1038/nature10774  PMID:22237024  PMCID:PMC3285539
    • Wiedenheft, B., Lander, G. C., Zhou, K., Jore, M. M., Brouns, S. J. J., van der Oost, J., Doudna, J. A., Nogales, E. Structures of the RNA-guided surveillance complex from a bacterial immune system Nature  2011 477:486-489  DOI:10.1038/nature10402  PMID:21938068  PMCID:PMC4165517
    • Hornung, P., Maier, M., Alushin, G. M., Lander, G. C., Nogales, E., Westermann, S. Molecular architecture and connectivity of the budding yeast Mtw1 kinetochore complex Journal of Molecular Biology  2011 405:548-559  DOI:10.1016/j.jmb.2010.11.012  PMID:21075115  PMCID:PMC3017645
    • degree-related publication Tang, J. H., Lander, G. C., Olia, A., Li, R., Casjens, S., Prevelige, P., Cingolani, G., Baker, T. S., Johnson, J. E. Peering down the barrel of a bacteriophage portal: the genome packaging and release valve in P22 Structure  2011 19:496-502  DOI:10.1016/j.str.2011.02.010  PMID:21439834  PMCID:PMC3075339
    • degree-related publication Huo, Y., Hu, Z., Zhang, K., Wang, L., Zhai, Y., Zhou, Q., Lander, G., Zhu, J., He, Y., Pang, X., Xu, W., Bartlam, M., et al. Crystal structure of group II chaperonin in the open state Structure  2010 18:1270-1279  DOI:10.1016/j.str.2010.07.009  PMID:20947016  PMCID:PMC3048791
    • degree-related publication Matsui, T., Lander, G. C., Khayat, R., Johnson, J. E. Subunits fold at position-dependent rates during maturation of a eukaryotic RNA virus Proceedings of the National Academy of Sciences of the United States of America  2010 107:14111-14115  DOI:10.1073/pnas.1004221107  PMID:20660783  PMCID:PMC2922577
    • degree-related publication Khayat, R., Lander, G. C., Johnson, J. E. An automated procedure for detecting protein folds from sub-nanometer resolution electron density Journal of Structural Biology  2010 170:513-521  DOI:10.1016/j.jsb.2009.12.014  PMID:20026407  PMCID:PMC2866771
    • degree-related publication Voss, N. R., Lyumkis, D., Cheng, A. C., Lau, P. W., Mulder, A., Lander, G. C., Brignole, E. J., Fellmann, D., Irving, C., Jacovetty, E. L., Leung, A., Pulokas, J., et al. A toolbox for ab initio 3-D reconstructions in single-particle electron microscopy Journal of Structural Biology  2010 169:389-398  DOI:10.1016/j.jsb.2009.12.005  PMID:20018246  PMCID:PMC2826578
    • degree-related publication Prust, C. J., Doerschuk, P. C., Lander, G. C., Johnson, J. E. Ab initio maximum likelihood reconstruction from cryo electron microscopy images of an infectious virion of the tailed bacteriophage P22 and maximum likelihood versions of Fourier Shell Correlation appropriate for measuring resolution of spherical or cylindrical objects Journal of Structural Biology  2009 167:185-199  DOI:10.1016/j.jsb.2009.04.013  PMID:19457456  PMCID:PMC2803348
    • degree-related publication Ambrose, R. L., Lander, G. C., Maaty, W. S., Bothner, B., Johnson, J. E., Johnson, K. N. Drosophila A virus is an unusual RNA virus with a T=3 icosahedral core and permuted RNA-dependent RNA polymerase Journal of General Virology  2009 90:2191-2200  DOI:10.1099/vir.0.012104-0  PMID:19474243  PMCID:PMC2742409
    • degree-related publication Lander, G. C., Khayat, R., Li, R., Prevelige, P. E., Potter, C. S., Carragher, B., Johnson, J. E. The P22 tail machine at subnanometer resolution reveals the architecture of an infection conduit Structure  2009 17:789-799  DOI:10.1016/j.str.2009.04.006  PMID:19523897  PMCID:PMC2714705
    • degree-related publication Lander, G. C., Stagg, S. M., Voss, N. R., Cheng, A., Fellmann, D., Pulokas, J., Yoshioka, C., Irving, C., Mulder, A., Lau, P. W., Lyumkis, D., Potter, C. S., et al. Appion: An integrated, database-driven pipeline to facilitate EM image processing Journal of Structural Biology  2009 166:95-102  DOI:10.1016/j.jsb.2009.01.002  PMID:19263523  PMCID:PMC2775544
    • degree-related publication Matsui, T., Lander, G., Johnson, J. E. Characterization of large conformational changes and autoproteolysis in the maturation of a T=4 virus capsid Journal of Virology  2009 83:1126-1134  DOI:10.1128/jvi.01859-08  PMID:18987141  PMCID:PMC2612371
    • degree-related publication Carrillo-Tripp, M., Shepherd, C. M., Borelli, I. A., Venkataraman, S., Lander, G., Natarajan, P., Johnson, J. E., Brooks, C. L., Reddy, V. S. VIPERdb(2): an enhanced and web API enabled relational database for structural virology Nucleic Acids Research  2009 37:D436-D442  DOI:10.1093/nar/gkn840  PMID:18981051  PMCID:PMC2686430
    • degree-related publication Nemecek, D., Lander, G. C., Johnson, J. E., Casjens, S. R., Thomas, G. J. Assembly architecture and DNA binding of the bacteriophage P22 terminase small subunit Journal of Molecular Biology  2008 383:494-501  DOI:10.1016/j.jmb.2008.08.050  PMID:18775728  PMCID:PMC2577774
    • degree-related publication Lander, G. C., Evilevitch, A., Jeembaeva, M., Potter, C. S., Carragher, B., Johnson, J. E. Bacteriophage lambda stabilization by auxiliary protein gpD: timing, location, and mechanism of attachment determined by cryo-EM Structure  2008 16:1399-1406  DOI:10.1016/j.str.2008.05.016  PMID:18786402  PMCID:PMC2614288
    • degree-related publication Stagg, S. M., Lander, G. C., Quispe, J., Voss, N. R., Cheng, A., Bradlow, H., Bradlow, S., Carragher, B., Potter, C. S. A test-bed for optimizing high-resolution single particle reconstructions Journal of Structural Biology  2008 163:29-39  DOI:10.1016/j.jsb.2008.04.005  PMID:18534866  PMCID:PMC2505049
    • degree-related publication Prasuhn, D. E., Kuzelka, J., Strable, E., Udit, A. K., Cho, S. H., Lander, G. C., Quispe, J. D., Diers, J. R., Bocian, D. F., Potter, C., Carragher, B., Finn, M. G. Polyvalent display of heme on hepatitis B virus capsid protein through coordination to hexahistidine tags Chemistry & Biology  2008 15:513-519  DOI:10.1616/j.chembiol.2008.03.018  PMID:18482703  PMCID:PMC2715361
    • degree-related publication Strable, E., Prasuhn, D. E., Udit, A. K., Link, A. J., Ngo, J. T., Lander, G., Quispe, J., Potter, C. S., Carragher, B., Tirrell, D. A., Finn, M. G. Unnatural amino acid incorporation into virus-like particles Bioconjugate Chemistry  2008 19:866-875  DOI:10.1021/bc700390r  PMID:18318461  PMCID:PMC2713011
    • degree-related publication Kang, S., Lander, G. C., Johnson, J. E., Prevelige, P. E. Development of bacteriophage P22 as a platform for molecular display: genetic and chemical modifications of the procapsid exterior surface ChemBioChem  2008 9:514-518  DOI:10.1002/cbic.200700555  PMID:18213564
    • degree-related publication Poliakov, A., van Duijn, E., Lander, G., Fu, C. Y., Johnson, J. E., Prevelige, P. E., Heck, A. J. R. Macromolecular mass spectrometry and electron microscopy as complementary tools for investigation of the heterogeneity of bacteriophage portal assemblies Journal of Structural Biology  2007 157:371-383  DOI:10.1016/j.jsb.2006.09.003  PMID:17064935
    • degree-related publication Fejeran, A., Polanco, J., Lander, G., Ajero, T., Carragher, B., Potter, C. S. TEM of bacteriophages found in marine sources Microscopy Today  2007 15:28-31
    • degree-related publication Gan, L., Speir, J. A., Conway, J. F., Lander, G., Cheng, N. Q., Firek, B. A., Hendrix, R. W., Duda, R. L., Liljas, L., Johnson, J. E. Capsid conformational sampling in HK97 maturation visualized by X-ray crystallography and cryo-EM Structure  2006 14:1655-1665  DOI:10.1016/j.str.2006.09.006  PMID:17098191
    • degree-related publication Stagg, S. M., Lander, G. C., Pulokas, J., Fellmann, D., Cheng, A. C., Quispe, J. D., Mallick, S. P., Avila, R. M., Carragher, B., Potter, C. S. Automated cryoEM data acquisition and analysis of 284742 particles of GroEL Journal of Structural Biology  2006 155:470-481  DOI:10.1016/j.jsb.2006.04.005  PMID:16762565
    • degree-related publication Lander, G. C., Tang, L., Casjens, S. R., Gilcrease, E. B., Prevelige, P., Poliakov, A., Potter, C. S., Carragher, B., Johnson, J. E. The structure of an infectious P22 virion shows the signal for headful DNA packaging Science  2006 312:1791-1795  DOI:10.1126/science.1127981  PMID:16709746
    • degree-related publication Shepherd, C. M., Borelli, I. A., Lander, G., Natarajan, P., Siddavanahalli, V., Bajaj, C., Johnson, J. E., Brooks, C. L., Reddy, V. S. VIPERdb: a relational database for structural virology Nucleic Acids Research  2006 34:D386-D389  DOI:10.1093/nar/gkj032  PMID:16381893  PMCID:PMC1347395
    • degree-related publication Natarajan, P., Lander, G. C., Shepherd, C. M., Reddy, V. S., Brooks, C. L., Johnson, J. E. Exploring icosahedral virus structures with VIPER Nature Reviews Microbiology  2005 3:809-817  DOI:10.1038/nrmicro1247  PMID:16205712
    • Berardini, T. Z., Mundodi, S., Reiser, L., Huala, E., Garcia-Hernandez, M., Zhang, P., Mueller, L. A., Yoon, J., Doyle, A., Lander, G., Moseyko, N., Yoo, D., et al. Functional annotation of the Arabidopsis genome using controlled vocabularies Plant Physiology  2004 135:745-755  DOI:10.1104/pp.104.040071  PMID:15173566  PMCID:PMC514112
    • Rhee, S. Y., Beavis, W., Berardini, T. Z., Chen, G., Dixon, D., Doyle, A., Garcia-Hernandez, M., Huala, E., Lander, G., Montoya, M., Miller, N., Mueller, L. A., et al. The Arabidopsis Information Resource (TAIR): a model organism database providing a centralized, curated gateway to Arabidopsis biology, research materials and community Nucleic Acids Research  2003 31:224-228  DOI:10.1093/nar/gkg076  PMID:12519987  PMCID:PMC165523
  • chapter

    • Reddy, V. S., Natarajan, P., Lander, G., Qu, C., Brooks, C. L., Johnson, J. E. Virus Particle Explorer (VIPER): a repository of virus capsid structures Conformational Proteomics of Macromolecular Architecture. 403-412. 2004

featured in

  • New Study Suggests Virus Uses Pressure to Sense when Full of DNA  News Release
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Research

research overview

  • The living cell is home to thousands of molecular machines that perform an astounding array of functions. Our group uses cryo-electron microscopy to characterize the structures of these large protein complexes in order to better understand their role in the cellular environment. In determining the molecular architecture of these nanomachines, which are generally made up of one or more copies of a single or even dozens of proteins, we gain a more comprehensive understanding of the mechanisms that underlie biological processes.

    Our current research focuses on the manner in which unwanted intracellular proteins are recognized and degraded by the 26S proteasome. Although the overall subunit organization of the proteasome has been determined, there are many questions surrounding the manner in which substrates are recognized by or transported to the proteasome, as well as how targeted proteins are unfolded and translocated to the proteolytic chamber. The answers to these questions would significantly improve our understanding of proteasome’s role in cellular homeostatis, potentially revealing novel approaches to detect and suppress the onset of tumorigenesis and neurodegeneration.

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Teaching

advisees

  • graduate advising relationship

    • Puchades Garcia, Cristina, Ph.D.  candidate, 2015 -
    • Sandate, Colby, Ph.D.  candidate, 2016 -
    • Shin, Mia, Ph.D.  candidate, 2017 -
    • Song, Albert, Ph.D.  candidate, 2019 -
    • Wu, Mengyu, Ph.D.  candidate, 2017 -
    • Grotjahn, Danielle, Ph.D.  candidate, 2014 - 2018
  • postdoc or fellow advising relationship

    • Grotjahn, Danielle, Ph.D.  candidate, 2018 -
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Background

education and training

  • Ph.D. in Biophysics, Scripps Research 2004 - 2009
  • B.S. in Biochemistry; Computer Science (minor), Binghamton University 1997 - 2002

advisee of

  • graduate advising relationship

    • Carragher, Bridget, Ph.D.  candidacy, 2005 - 2009
    • Johnson Jr., John, Ph.D.  candidacy, 2005 - 2009
    • Potter, Clinton, Ph.D.  candidacy, 2005 - 2009
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Contact

full name

  • Gabriel C. Lander

geographic location

  • Scripps California 
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Identity

ORCID iD

  • ORCID iD http://orcid.org/0000-0003-4921-1135

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